Randomized Trials
RCT | Sodium bicarbonate over 2 years was not beneficial for kidney transplant recipients with metabolic acidosis
27 Jan, 2023 | 12:23h | UTCSodium bicarbonate for kidney transplant recipients with metabolic acidosis in Switzerland: a multicentre, randomised, single-blind, placebo-controlled, phase 3 trial – The Lancet (link to abstract – $ for full-text)
RCT | High-dose steroid in low pain responders undergoing total knee arthroplasty
27 Jan, 2023 | 12:08h | UTC
RCT | Duration of prophylactic levetiracetam after surgery for brain tumor
27 Jan, 2023 | 12:06h | UTC
Commentary on Twitter
#NEULatestArticle #NEUVisualAbstract Duration of Prophylactic Levetiracetam After Surgery for Brain Tumor: A Prospective Randomized Trial https://t.co/O8wAgwK0SL by Rahman et al @UFHealth @CNS_Update @DKondziolkaCNS @IsaacYangMD #Seizures #BrainTumor pic.twitter.com/ALVEw91oiZ
— Neurosurgery Publications (@NeurosurgeryCNS) October 6, 2022
M-A | Microsurgery vs. microsurgery with preoperative embolization for brain arteriovenous malformation treatment
27 Jan, 2023 | 12:05h | UTC
RCT | Shoulder stretching vs. shoulder muscle strength training for the prevention of baseball-related arm injuries
27 Jan, 2023 | 11:57h | UTC
Commentary on Twitter
Shoulder stretching versus shoulder muscle strength training for the prevention of baseball-related arm injuries: a randomized, active-controlled, open-label, non-inferiority studyhttps://t.co/9tsPkWyVdU pic.twitter.com/eihYv5EdRE
— Physio Meets Science (@PhysioMeScience) December 22, 2022
RCT | Curettage plus platelet-rich plasma gel vs. curettage plus phenol application in treatment of pilonidal sinus disease
26 Jan, 2023 | 12:05h | UTCComparison of Curettage Plus Platelet-Rich Plasma Gel and Curettage Plus Phenol Application in Treatment of Pilonidal Sinus Disease: A Randomized Trial – Diseases of the Colon & Rectum (link to abstract – $ for full-text)
See also: Visual Abstract
RCT | Postoperative adjuvant hepatic arterial infusion chemotherapy with FOLFOX in hepatocellular carcinoma with microvascular invasion
26 Jan, 2023 | 12:03h | UTC
RCT | Preoperative chemotherapy reduced recurrence in operable colon cancer
25 Jan, 2023 | 11:29h | UTCEditorial: FOxTROT: Are We Ready to Dance? – Journal of Clinical Oncology
News Release: Chemotherapy before surgery cuts risk of colon cancer returning, trial finds – Cancer Research UK
Commentary: New treatment strategy cuts risk of bowel cancer returning by 28% – The Guardian
Commentary from one of the authors on Twitter (thread – click for more)
🥁🥁🥁Tweetorial
FOxTROT, the 1st ph 3 RCT of neoadjuvant chemo (NAC) in locally advanced colon cancer
We report that NAC is
✅deliverable and safe
✅led to statistically significant reduction in cancer recurrence than upfront surgery
A 🧵 (1/14)#crcsmhttps://t.co/y1hU6qWdXF— Jenny Seligmann (@JenSeligmann) January 20, 2023
RCT | Monitoring of cerebral tissue oxygen saturation to guide oxygen delivery in preterm neonates did not improve outcomes
25 Jan, 2023 | 11:23h | UTC
RCT | 2 days of postoperative antibiotics is noninferior to 5 days in patients with complex appendicitis
24 Jan, 2023 | 14:33h | UTC2 days versus 5 days of postoperative antibiotics for complex appendicitis: a pragmatic, open-label, multicentre, non-inferiority randomised trial – The Lancet (link to abstract – $ for full-text)
Commentary: Trial supports shorter postoperative antibiotics for complex appendicitis – CIDRAP
Commentary on Twitter
After laparoscopic appendicectomy for complex appendicitis, 2 days versus 5 days of intravenous #antibiotics was non-inferior in terms of infectious complications and mortality within 90 days, suggests new Dutch study: https://t.co/oRsf8BQgAd
— The Lancet (@TheLancet) January 19, 2023
RCT | Intracorporeal vs. extracorporeal anastomosis in robotic right colectomy
24 Jan, 2023 | 14:17h | UTCIntracorporeal Versus Extracorporeal Anastomosis in Robotic Right Colectomy: A Multicenter, Triple-blind, Randomized Clinical Trial – Annals of Surgery (link to abstract – $ for full-text)
RCT | Standard threshold laser versus subthreshold micropulse laser for adults with diabetic macular edema
24 Jan, 2023 | 14:02h | UTCOriginal Publication: Diabetic Macular Edema and Diode Subthreshold Micropulse Laser: A Randomized Double-Masked Noninferiority Clinical Trial – Ophthalmology
RCT | Effects of a web-guided system for self-treatment of recurrent benign paroxysmal positional vertigo
23 Jan, 2023 | 13:43h | UTCEffect of Self-treatment of Recurrent Benign Paroxysmal Positional Vertigo: A Randomized Clinical Trial – JAMA Neurology (free for a limited period)
Related Video: Web-Guided Canalith Reposition Maneuver – JAMA
Commentary: Web-Based System Works Well for Diagnosis, Treatment of Recurrent Vertigo – HealthDay
Commentary on Twitter
Patients may benefit from treating benign paroxysmal positional vertigo themselves using a web-guided system. https://t.co/9Hjwb0XGnl
— JAMA Neurology (@JAMANeuro) January 20, 2023
RCT | Adjuvant S-1 compared with observation in resected biliary tract cancer
23 Jan, 2023 | 13:24h | UTCAdjuvant S-1 compared with observation in resected biliary tract cancer (JCOG1202, ASCOT): a multicentre, open-label, randomised, controlled, phase 3 trial – The Lancet (link to abstract – $ for full-text)
Commentary on Twitter
New @TheLancet – Nakachi et al – Adjuvant S-1 compared with observation in resected biliary tract cancer (JCOG1202, ASCOT): a multicentre, open-label, randomised, controlled, phase 3 trial https://t.co/E6y7a9dWNf#gitwitter #biliarytractcancer #onctwitter @OncoAlert #JCOG pic.twitter.com/WEBFXjIWce
— The Lancet Gastroenterology & Hepatology (@LancetGastroHep) January 20, 2023
RCT | Small study suggests hybrid ablation is more effective than repeated catheter ablation in persistent atrial fibrillation
23 Jan, 2023 | 13:23h | UTC
RCT | Oral ibuprofen and oral ketorolac are similarly effective for children with acute traumatic pain
20 Jan, 2023 | 14:47h | UTC
RCT | Routine use of endometrial receptivity testing to guide the timing of frozen embryo transfer did not improve the rates of live birth
20 Jan, 2023 | 14:45h | UTCEffect of Timing by Endometrial Receptivity Testing vs Standard Timing of Frozen Embryo Transfer on Live Birth in Patients Undergoing In Vitro Fertilization: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)
Commentary on Twitter
Study findings do not support routine use of receptivity testing to guide the timing of embryo transfer during in vitro fertilization. https://t.co/p8jqTpRAfV #Research
— JAMA (@JAMA_current) December 6, 2022
An overview of methodological considerations regarding adaptive stopping, arm dropping, and randomization in clinical trials
20 Jan, 2023 | 14:27h | UTC
Commentary from the author on Twitter
Now online in @JClinEpi (OA): https://t.co/Ton5G8x2sH
In this manuscript we provide an overview of the key methodological considerations for (multi-arm, multi-stage) clinical trials using adaptive stopping, arm dropping, and randomisation with a worked example. Details below 1/— Anders Granholm (@andersgranholm) November 16, 2022
Under a Creative Commons Attribution (CC BY 4.0) License
RCT | Bilateral ultrasound-guided erector spinae plane block vs. wound infiltration for postoperative analgesia in lumbar spinal fusion surgery
20 Jan, 2023 | 14:18h | UTC
RCT | No difference in survival with Torsemide vs. Furosemide after discharge of patients hospitalized with heart failure
19 Jan, 2023 | 14:26h | UTCEffect of Torsemide vs Furosemide After Discharge on All-Cause Mortality in Patients Hospitalized With Heart Failure: The TRANSFORM-HF Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: TRANSFORM-HF—Can We Close the Loop on Diuretics in Heart Failure? – JAMA (free for a limited period)
News Release: Comparison of diuretics shows no difference in heart failure survival – NIH/National Heart, Lung and Blood Institute
Commentary on Twitter
Among patients discharged after hospitalization for heart failure, torsemide compared with furosemide did not result in a significant difference in all-cause mortality over 12 months. https://t.co/EwoVzRigkS pic.twitter.com/5dvhJ1oVaf
— JAMA (@JAMA_current) January 17, 2023
RCT | SPONGE-assisted vs. Trendelenburg position surgery in laparoscopic sigmoid and rectal cancer surgery
19 Jan, 2023 | 14:06h | UTCSPONGE-assisted vs. Trendelenburg position surgery in laparoscopic sigmoid and rectal cancer surgery (SPONGE trial): randomized clinical trial – British Journal of Surgery (link to abstract – $ for full-text)
RCT | Bimekizumab in patients with active psoriatic arthritis and previous inadequate response or intolerance to TNFα inhibitors
19 Jan, 2023 | 14:05h | UTC
RCT | Effectiveness of an intervention to improve decision making for older patients with advanced CKD
19 Jan, 2023 | 14:04h | UTCEffectiveness of an Intervention to Improve Decision Making for Older Patients With Advanced Chronic Kidney Disease: A Randomized Controlled Trial – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentary: Digital decision aid may be useful for older adults with CKD – ACP Internist
Commentary on Twitter
A #RCT of older adults w/ #CKD found use of decision-making aid DART improved decision quality & clarified treatment preferences for older adults w/ advanced CKD 6 months after intervention: https://t.co/JP0TO7givB @KerenLadin @TuftsMedicalCtr pic.twitter.com/pXPyg1iKAS
— Annals of Int Med (@AnnalsofIM) December 20, 2022
RCT | Prevention of incisional hernias by prophylactic mesh-augmented reinforcement of midline laparotomies for AAA treatment
19 Jan, 2023 | 14:03h | UTC
RCT | Aqueous povidone-iodine vs. normal saline for intraoperative wound irrigation on the incidence of SSI after GI surgery
19 Jan, 2023 | 13:54h | UTCAqueous Povidone-Iodine Versus Normal Saline For Intraoperative Wound Irrigation On The Incidence Of Surgical Site Infection In Clean-Contaminated Wounds After Gastroenterological Surgery: A Single Institute, Prospective, Blinded-Endpoint, Randomized Controlled Trial – Annals of Surgery (link to abstract – $ for full-text)