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Randomized Trials

Conflicting results from 2 randomized trials testing Tocilizumab for Covid-19

26 Feb, 2021 | 08:48h | UTC

Study 1: Tocilizumab in Hospitalized Patients with Severe Covid-19 Pneumonia – New England Journal of Medicine

Study 2: Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19 – New England Journal of Medicine

Editorial: Interleukin-6 Receptor Inhibition in Covid-19 — Cooling the Inflammatory Soup – New England Journal of Medicine

 

Commentary on Twitter

 


Phase 2 trial: Muscarinic cholinergic receptor agonist and peripheral antagonist for schizophrenia

26 Feb, 2021 | 08:30h | UTC

Muscarinic Cholinergic Receptor Agonist and Peripheral Antagonist for Schizophrenia – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Phase II Results Promising for New Schizophrenia Drug Combo – MedPage Today

 


RCT: Topical intranasal tranexamic acid does not reduce the need for nasal packing in epistaxis

21 Feb, 2021 | 22:02h | UTC

The Use of Tranexamic Acid to Reduce the Need for Nasal Packing in Epistaxis (NoPAC): Randomized Controlled Trial – Annals of Emergency Medicine (link to abstract – $ for full-text)

 

Commentary on Twitter

 


RCT: Five oral analgesics (including opioids) are equally effective for the treatment of acute musculoskeletal extremity pain in the emergency department

21 Feb, 2021 | 21:39h | UTC

A Randomized Trial Comparing the Efficacy of Five Oral Analgesics for Treatment of Acute Musculoskeletal Extremity Pain in the Emergency Department – Annals of Emergency Medicine (link to abstract – $ for full-text)

 

Commentary on Twitter

 


RCT: Vitamin D3 does not improve outcomes in hospitalized patients with moderate to severe COVID-19

18 Feb, 2021 | 03:20h | UTC

Effect of a Single High Dose of Vitamin D3 on Hospital Length of Stay in Patients With Moderate to Severe COVID-19: A Randomized Clinical Trial – JAMA

Editorial: Vitamin D3 to Treat COVID-19: Different Disease, Same Answer

 

 


RCT: Levonorgestrel-releasing intrauterine system vs. endometrial ablation for heavy menstrual bleeding

18 Feb, 2021 | 02:38h | UTC

Levonorgestrel-releasing intrauterine system versus endometrial ablation for heavy menstrual bleeding – American Journal of Obstetrics & Gynecology

 


RCT: Cemiplimab monotherapy for first-line treatment of advanced non-small-cell lung cancer with PD-L1 of at least 50%

18 Feb, 2021 | 02:34h | UTC

Cemiplimab monotherapy for first-line treatment of advanced non-small-cell lung cancer with PD-L1 of at least 50%: a multicentre, open-label, global, phase 3, randomised, controlled trial – The Lancet

 

Commentary on Twitter

 


RCT: Among patients with knee osteoarthritis, high-intensity strength training was not associated with better outcomes compared with low-intensity strength training or an attention control

17 Feb, 2021 | 01:24h | UTC

Effect of High-Intensity Strength Training on Knee Pain and Knee Joint Compressive Forces Among Adults With Knee Osteoarthritis: The START Randomized Clinical Trial – JAMA

Commentary: No Benefit from High-Intensity Strength Training for Knee Osteoarthritis – NEJM Journal Watch

 

Commentary on Twitter

 


RCT: Short-term outcomes of complete mesocolic excision versus D2 dissection in patients undergoing laparoscopic colectomy for right colon cancer

16 Feb, 2021 | 01:44h | UTC

Short-term outcomes of complete mesocolic excision versus D2 dissection in patients undergoing laparoscopic colectomy for right colon cancer (RELARC): a randomised, controlled, phase 3, superiority trial – The Lancet Oncology (link to abstract – $ for full-text)

 


How effective is magnesium in for the treatment of migraine?

16 Feb, 2021 | 01:48h | UTC

How Effective is Magnesium in your MAGraine Cocktail? – Journal Feed

Original study: MAGraine: Magnesium compared to conventional therapy for treatment of migraines – American Journal of Emergency Medicine

 


Opinion: RECOVERY confirms benefit of tocilizumab combined with dexamethasone

16 Feb, 2021 | 02:09h | UTC

PulmCrit – RECOVERY confirms benefit of toci combined with dexamethasone

Original study: RCT: Tocilizumab reduces deaths in patients hospitalized with COVID-19 (study and commentaries)

 


RCT: Delayed antibiotic prescription feasible for children with uncomplicated respiratory infections

12 Feb, 2021 | 02:02h | UTC

Delayed Antibiotic Prescription for Children With Respiratory Infections: A Randomized Trial – Pediatrics (link to abstract – $ for full-text)

Commentary: Data support delayed antibiotics in kids with respiratory infections – CIDRAP

 


RCT: Tocilizumab reduces deaths in patients hospitalized with COVID-19

12 Feb, 2021 | 02:25h | UTC

Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): preliminary results of a randomised, controlled, open-label, platform trial – medRxiv

News release: Tocilizumab reduces deaths in patients hospitalised with COVID-19 – University of Oxford

Commentary: Tocilizumab cuts death rate in severe COVID-19, study finds – CIDRAP

 

Commentary on Twitter

 


RCT: Once-weekly, high-dose semaglutide is effective for improving overweight or obesity among non-diabetic adults

11 Feb, 2021 | 02:09h | UTC

Once-Weekly Semaglutide in Adults with Overweight or Obesity – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Semaglutide Plus Lifestyle Change Shown Effective for Obesity – NEJM Journal Watch

 

Commentary on Twitter

 


Randomized, cross-over trial: Compared to Mediterranean diet, a Low-fat vegan diet is better at improving body weight, lipid concentrations, and insulin sensitivity

11 Feb, 2021 | 01:56h | UTC

A Mediterranean Diet and Low-Fat Vegan Diet to Improve Body Weight and Cardiometabolic Risk Factors: A Randomized, Cross-over Trial – Journal of the American College of Nutrition

Commentary: Vegan diet associated with more weight loss, better cholesterol control than Mediterranean diet – Cardiovascular Business

Commentary: Vegan diet associated with more weight loss, better cholesterol control than Mediterranean diet – Cardiovascular Business

 

Commentary on Twitter

 


RCT: The effect of daily protein supplementation, with or without resistance training for 1 year, on muscle size, strength, and function in healthy older adults

11 Feb, 2021 | 01:58h | UTC

The effect of daily protein supplementation, with or without resistance training for 1 year, on muscle size, strength, and function in healthy older adults: A randomized controlled trial – The American Journal of Clinical Nutrition (link to abstract – $ for full-text)

 

Commentary on Twitter

 


RCT: Among patients undergoing transurethral resection of the prostate, it is safe to withhold antimicrobial prophylaxis for those without pre-operative pyuria or a pre-operative, indwelling catheter

11 Feb, 2021 | 01:52h | UTC

Antimicrobial Prophylaxis (AMP) in Transurethral Resection of the Prostate (TURP): Results of a Randomized Trial – The Journal of Urology

 


Small RCT: Inhaled budesonide reduces the need for hospitalization in COVID-19 patients

11 Feb, 2021 | 02:18h | UTC

Inhaled budesonide in the treatment of early COVID-19 illness: a randomised controlled trial – medRxiv

Commentaries: Common asthma treatment reduces need for hospitalisation in COVID-19 patients, study suggests – University of Oxford AND Expert reaction to preprint on an RCT of inhaled budesonide in the treatment of early COVID-19 – Science Media Centre

 


RCT: Among patients with acute MI and anemia, a restrictive transfusion strategy resulted in a noninferior rate of major cardiovascular events compared to a liberal transfusion strategy

10 Feb, 2021 | 01:39h | UTC

Effect of a Restrictive vs Liberal Blood Transfusion Strategy on Major Cardiovascular Events Among Patients With Acute Myocardial Infarction and Anemia: The REALITY Randomized Clinical Trial – JAMA (free for a limited period)

Commentary: Restrictive vs. Liberal Blood Transfusion Strategy for MI and Anemia – American College of Cardiology

 

Commentary on Twitter

 


RCT: In patients with generalized myasthenia gravis prescribed azithromycin, rapid tapering of prednisone is beneficial and safe compared to slow tapering

10 Feb, 2021 | 01:32h | UTC

Comparison of Corticosteroid Tapering Regimens in Myasthenia Gravis: A Randomized Clinical Trial – JAMA Neurology

 

Commentary on Twitter

 


RCT: Among children with Myelomeningocele, long term results confirm the benefits of prenatal repair compared to standard postnatal repair

10 Feb, 2021 | 01:28h | UTC

Prenatal Repair and Physical Functioning Among Children With Myelomeningocele: A Secondary Analysis of a Randomized Clinical Trial – JAMA Pediatrics (free for a limited period)

Editorial: Long-term Outcomes of Children After Fetal Surgery for Spina Bifida—Toward Sustainability – JAMA Pediatrics (free for a limited period)

Commentaries: Spina Bifida Repair: The Sooner the Better – Physician’s Weekly AND Prenatal Myelomeningocele Repair Tied to Better Function – HealthDay

 

Commentary on Twitter

 


RCT: Dobutamine-sparing vs. dobutamine-to-all strategy in cardiac surgery

9 Feb, 2021 | 00:57h | UTC

Dobutamine-sparing versus dobutamine-to-all strategy in cardiac surgery: a randomized noninferiority trial – Annals of Intensive Care

 


RCT: Total Body Irradiation vs. Chemotherapy Conditioning in Childhood ALL

9 Feb, 2021 | 00:39h | UTC

Total Body Irradiation or Chemotherapy Conditioning in Childhood ALL: A Multinational, Randomized, Noninferiority Phase III Study – Journal of Clinical Oncology

Commentary: TBI Beats Chemoconditioning for ALL Transplants in Children – Medscape (free registration required)

 

Commentary on Twitter

 


Small RCT: Peginterferon lambda increases viral clearance in outpatients with COVID-19

9 Feb, 2021 | 01:36h | UTC

Peginterferon lambda for the treatment of outpatients with COVID-19: a phase 2, placebo-controlled randomised trial – The Lancet Respiratory Medicine

 


RCT: Day-of-surgery video calls and phone calls increase patient satisfaction with outpatient surgery experience

9 Feb, 2021 | 00:44h | UTC

Day-of-Surgery Video Calls and Phone Calls Increase Patient Satisfaction with Outpatient Surgery Experience: A Randomized Controlled Trial of Postoperative Communication Modalities – The Journal of Bone and Joint Surgery

Commentary: Day-of-Surgery Post-op Talks with Patients Worth the Effort – OrthoBuzz

 


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