Randomized Trials
RCT: Effect of banded Roux-en-Y gastric bypass versus sleeve gastrectomy on diabetes remission at 5 years among patients with obesity and type 2 diabetes.
24 Jun, 2022 | 11:10h | UTCEffect of Banded Roux-en-Y Gastric Bypass Versus Sleeve Gastrectomy on Diabetes Remission at 5 Years Among Patients With Obesity and Type 2 Diabetes: A Blinded Randomized Clinical Trial – Diabetes Care (link to abstract – $ for full-text)
RCT: Effect of MRI-guided fibrosis ablation vs. conventional catheter ablation on atrial arrhythmia recurrence in patients with persistent atrial fibrillation.
23 Jun, 2022 | 12:57h | UTCEffect of MRI-Guided Fibrosis Ablation vs Conventional Catheter Ablation on Atrial Arrhythmia Recurrence in Patients With Persistent Atrial Fibrillation: The DECAAF II Randomized Clinical Trial – JAMA (free for a limited period)
News Release: Global AFib study finds simple approach is best for ablation procedures – Tulane University
Commentary on Twitter
Randomized clinical trial of patients with persistent #atrialfibrillation found no significant difference in atrial arrhythmia recurrence in the MRI-guided fibrosis ablation group compared with the pulmonary vein isolation only group. https://t.co/mCyNR4rpTH
— JAMA (@JAMA_current) June 21, 2022
RCTs: Once daily oral relugolix combination therapy vs. placebo in patients with endometriosis-associated pain.
23 Jun, 2022 | 10:30h | UTCCommentaries:
Relugolix combination therapy for endometriosis pain – The Lancet (free registration required)
Commentary on Twitter
Treatment options for #endometriosis-associated pain are suboptimal.
Two new studies indicate once-daily relugolix combination therapy significantly improved pain and was well tolerated. 1/2 https://t.co/LBFgTMZSO2
— The Lancet (@TheLancet) June 21, 2022
RCT: Weaning of maintenance immunosuppressive therapy in lupus nephritis.
23 Jun, 2022 | 10:18h | UTC
RCT: Effect of laparoscopic sleeve gastrectomy vs Roux-en-Y Gastric bypass on weight loss, comorbidities, and reflux at 10 years in adult patients with obesity.
23 Jun, 2022 | 10:17h | UTCEffect of Laparoscopic Sleeve Gastrectomy vs Roux-en-Y Gastric Bypass on Weight Loss, Comorbidities, and Reflux at 10 Years in Adult Patients With Obesity: The SLEEVEPASS Randomized Clinical Trial – JAMA Surgery (free for a limited period)
Commentary on Twitter
10-year follow-up of the SLEEVEPASS RCT: both sleeve and gastric bypass resulted in good #weightloss. Reflux was more prevalent after sleeve. The incidence of #Barrettesophagus was much lower than in previous trials, and similar after both procedures. https://t.co/zRLzB6Nf7a
— JAMA Surgery (@JAMASurgery) June 22, 2022
RCTs: Risankizumab as induction therapy for Crohn’s disease.
23 Jun, 2022 | 10:02h | UTCRisankizumab as induction therapy for Crohn’s disease: results from the phase 3 ADVANCE and MOTIVATE induction trials – The Lancet (link to abstract – $ for full-text)
Related: Risankizumab as maintenance therapy for moderately to severely active Crohn’s disease: results from the multicentre, randomised, double-blind, placebo-controlled, withdrawal phase 3 FORTIFY maintenance trial – The Lancet (link to abstract – $ for full-text)
Commentary on Twitter
In patients with moderately to severely active Crohn's disease, risankizumab was effective and well tolerated as induction therapy, studies indicate.
Find out more: https://t.co/zg70L8RYka #crohnsdisease pic.twitter.com/9evGJAH8ke
— The Lancet (@TheLancet) June 1, 2022
RCT: Spinal anesthesia is associated with more pain and prescription analgesic use after hip surgery compared to general anesthesia.
22 Jun, 2022 | 12:11h | UTCStudy: Pain, Analgesic Use, and Patient Satisfaction With Spinal Versus General Anesthesia for Hip Fracture Surgery: A Randomized Clinical Trial – Annals of Internal Medicine (link to abstract – $ for full-text)
Original Publication: Spinal Anesthesia or General Anesthesia for Hip Surgery in Older Adults – New England Journal of Medicine
Commentary: Spinal Anesthesia Tied to More Severe Pain After Hip Fracture Surgery – HealthDay
Related:
RCT: Efficacy and safety of varenicline for smoking cessation in patients with type 2 diabetes.
22 Jun, 2022 | 11:16h | UTCAuthor Interview: Efficacy and Safety of Varenicline in Patients With Type 2 Diabetes – JAMA
Commentary on Twitter
This randomized clinical trial (CoEHAR) found the use of varenicline in smoking cessation programs for patients with diabetes resulted in prolonged abstinence. @CoeharUnict @RiccardoPolosa https://t.co/Sd57LMcsbJ
— JAMA Network Open (@JAMANetworkOpen) June 21, 2022
RCT: Multispecies probiotic for the prevention of antibiotic-associated diarrhea in children.
22 Jun, 2022 | 11:12h | UTCMultispecies Probiotic for the Prevention of Antibiotic-Associated Diarrhea in Children: A Randomized Clinical Trial – JAMA Pediatrics (free for a limited period)
Commentary: Mixed Results With Probiotic for Kids’ Antibiotic-Related Diarrhea— Randomized trial misses strictly defined endpoint, but researchers point to benefit – MedPage Today (free registration required)
Commentary on Twitter
Study found administration of a multispecies #probiotic to children had no significant effect on the risk of antibiotic-associated diarrhea caused by #Cdifficile or of unknown etiology, but reduced the overall risk of diarrhea regardless of the etiology. https://t.co/Mdq3tl8csb
— JAMA Pediatrics (@JAMAPediatrics) June 21, 2022
RCT: Modified ligation procedure for prolapsed hemorrhoids vs. stapled hemorrhoidectomy for the management of symptomatic hemorrhoids.
22 Jun, 2022 | 10:59h | UTC
Commentary on Twitter
#haemorrhoid #RCT comparing #stapled vs modified ligation
n = 133
modified ligation showed lower pain, incontinence, and recurrence at 6 months.
See article for explanation of technique#some4surgery@SEIQuirurgica @asgbi @SocSARS @ASiTofficial https://t.co/THRpO1YM6n pic.twitter.com/ux9DGMxBti— BJS Open (@BjsOpen) May 20, 2022
Phase II RCT: Switch maintenance endocrine therapy plus bevacizumab after bevacizumab plus paclitaxel in advanced or metastatic estrogen receptor-positive, HER2-negative breast cancer.
22 Jun, 2022 | 10:49h | UTCSwitch maintenance endocrine therapy plus bevacizumab after bevacizumab plus paclitaxel in advanced or metastatic oestrogen receptor-positive, HER2-negative breast cancer (BOOSTER): a randomised, open-label, phase 2 trial – The Lancet Oncology (link to abstract – $ for full-text)
RCT: In people with HIV, treating precancerous anal lesions cuts risk of anal cancer by more than half.
21 Jun, 2022 | 11:11h | UTCOriginal Study: Treatment of Anal High-Grade Squamous Intraepithelial Lesions to Prevent Anal Cancer – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary on Twitter
Randomized trial showed that treating anal high-grade squamous intraepithelial lesions (HSILs) led to a 57% reduction in progression to anal cancer as compared with active surveillance. https://t.co/iulcskP61C pic.twitter.com/Q6Oqty3hgW
— NEJM (@NEJM) June 15, 2022
RCT: Guided, internet based, cognitive behavioral therapy noninferior to individual face-to-face CBT for patients with post-traumatic stress disorder.
21 Jun, 2022 | 11:06h | UTC
RCT: Lisocabtagene maraleucel vs. standard of care with salvage chemotherapy followed by autologous stem cell transplantation as second-line treatment in patients with relapsed or refractory large B-cell lymphoma.
21 Jun, 2022 | 10:48h | UTCLisocabtagene maraleucel versus standard of care with salvage chemotherapy followed by autologous stem cell transplantation as second-line treatment in patients with relapsed or refractory large B-cell lymphoma (TRANSFORM): results from an interim analysis of an open-label, randomised, phase 3 trial – The Lancet (link to abstract – $ for full-text)
RCT: Transfer of thawed frozen embryo versus fresh embryo to improve the healthy baby rate in women undergoing IVF.
21 Jun, 2022 | 10:32h | UTCRelated: Fresh versus frozen embryo transfers in assisted reproduction – Cochrane Library
RCT: Active surveillance plus Enzalutamide monotherapy vs. active surveillance alone in patients with low-risk or intermediate-risk localized prostate cancer.
21 Jun, 2022 | 10:33h | UTCInvited Commentary: To Treat or Not to Treat Men With Low-risk or Intermediate-risk Prostate Cancer—Weighing the Evidence – JAMA Oncology (free for a limited period)
Video criticizing the article: ENACT trial | A Study That Makes Pharma Rich and Patients’ Poor | I break it down – by Vinay Prasad
Commentaries on Twitter
55% fatigue and 36% gynecomastia. In AS patients.
Why do we keep trying to escalate when the data CLEARLY say we should continue to de-escalate? https://t.co/LY1kD0jN65
— Chris Barbieri (@Chris_Barbieri1) June 17, 2022
The phase 2, open-label ENACT trial compares the efficacy & safety of enzalutamide monotherapy vs active surveillance in patients with low- or intermediate-risk localized #prostatecancer. https://t.co/q9FrL14em1 #PCSM #GUCSM
— JAMA Oncology (@JAMAOnc) June 16, 2022
Cluster RCT: Evaluation of a multicomponent intervention consisting of education and feedback to reduce benzodiazepine prescriptions by general practitioners.
21 Jun, 2022 | 10:29h | UTC
RCT: Immune enhancement with Thymosin alpha 1 does not improve outcomes in patients with predicted severe acute necrotizing pancreatitis.
20 Jun, 2022 | 01:11h | UTCImmune enhancement in patients with predicted severe acute necrotising pancreatitis: a multicentre double-blind randomised controlled trial – Intensive Care Medicine (if the link is paywalled, try this one)
RCT: Safety and efficacy of Eptinezumab for migraine prevention in patients with two-to-four previous preventive treatment failures.
20 Jun, 2022 | 01:01h | UTCSafety and efficacy of eptinezumab for migraine prevention in patients with two-to-four previous preventive treatment failures (DELIVER): a multi-arm, randomised, double-blind, placebo-controlled, phase 3b trial – The Lancet Neurology (link to abstract – $ for full-text)
#CCR22 – RCT: Intravenous Vitamin C increases the risk of death or persistent organ dysfunction in adults with sepsis in the intensive care unit.
16 Jun, 2022 | 11:13h | UTCRelated:
Commentary on Twitter
In this trial of IV vitamin C in adult patients with sepsis, those who received a vitamin C infusion had a higher risk of death or persistent organ dysfunction at 28 days than those who received placebo. #CCR22 https://t.co/8tpW7Yud6a pic.twitter.com/1Jf9aIka8Y
— NEJM (@NEJM) June 15, 2022
RCT: Discontinuation of Infliximab therapy in patients with Crohn’s disease.
15 Jun, 2022 | 10:54h | UTCDiscontinuation of Infliximab Therapy in Patients with Crohn’s Disease – NEJM Evidence
RCT: Marine Omega-3 Fatty acid supplementation does not reduce the incidence of dry eye disease in healthy adults.
10 Jun, 2022 | 12:25h | UTCEfficacy of Marine ω-3 Fatty Acid Supplementation vs Placebo in Reducing Incidence of Dry Eye Disease in Healthy US Adults: A Randomized Clinical Trial – JAMA Ophthalmology (free for a limited period)
Invited Commentary: Another Disappointment for ω-3 Fatty Acid and Dry Eye Disease – JAMA Ophthalmology (free for a limited period)
Commentary on Twitter
In this randomized clinical trial, daily supplementation with marine omega-3 fatty acids (1 gram) for a median of 5.3 years had no significant effect on the incidence of diagnosed #dryeyedisease (DED) or reported DED symptoms. https://t.co/iTBONh6CZK
— JAMAOphthalmology (@JAMAOphth) June 9, 2022
Neck circumference measurement for surveillance and early detection of hemorrhage after thyroidectomy: a diagnostic accuracy study.
10 Jun, 2022 | 11:39h | UTCNeck Circumference Measurement for Surveillance and Early Detection of Hemorrhage After Thyroidectomy: A Diagnostic Accuracy Study – JAMA Otolaryngology-Head & Neck Surgery (free for a limited period)
Commentary on Twitter
Study evaluated neck circumference measurements as a diagnostic tool to improve patient’s safety in thyroid surgery. An increase of 7% or more seemed to be specific for post-thyroidectomy hemorrhage along with other clinical signs. https://t.co/HQqjv3svRx #thyroidectomy
— JAMA Otolaryngology – Head & Neck Surgery (@JAMAOto) June 9, 2022
RCT: Effect of electronic symptom monitoring on patient-reported outcomes among patients with metastatic cancer.
8 Jun, 2022 | 11:14h | UTCEffect of Electronic Symptom Monitoring on Patient-Reported Outcomes Among Patients With Metastatic Cancer: A Randomized Clinical Trial – JAMA (free for a limited period)
Related:
Digital remote monitoring plus usual care versus usual care in patients treated with oral anticancer agents: the randomized phase 3 CAPRI trial – Nature Medicine (if the link is paywalled, try this one)
Key components of successful digital remote monitoring in oncology – Nature Medicine
Do we need to reconsider how we design and conduct randomized controlled trials?
8 Jun, 2022 | 10:56h | UTC