Randomized Trials | Links Medicus Free Medical News & Perspectives

Conflicting results from 2 randomized trials testing Tocilizumab for Covid-19

26 Feb, 2021 | 08:48h | UTC

Study 1: Tocilizumab in Hospitalized Patients with Severe Covid-19 Pneumonia – New England Journal of Medicine

Study 2: Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19 – New England Journal of Medicine

Editorial: Interleukin-6 Receptor Inhibition in Covid-19 — Cooling the Inflammatory Soup – New England Journal of Medicine

Commentary on Twitter

Why do 2 randomized trials of tocilizumab, an interleukin-6 blocker, for severe covid-19, have opposite results?
Today @NEJM https://t.co/g8LCrhhpLy https://t.co/BcN3wOwsl0 pic.twitter.com/sLrQUYI1pf

— Eric Topol (@EricTopol) February 25, 2021

Phase 2 trial: Muscarinic cholinergic receptor agonist and peripheral antagonist for schizophrenia

26 Feb, 2021 | 08:30h | UTC

Muscarinic Cholinergic Receptor Agonist and Peripheral Antagonist for Schizophrenia – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Phase II Results Promising for New Schizophrenia Drug Combo – MedPage Today

RCT: Topical intranasal tranexamic acid does not reduce the need for nasal packing in epistaxis

21 Feb, 2021 | 22:02h | UTC

The Use of Tranexamic Acid to Reduce the Need for Nasal Packing in Epistaxis (NoPAC): Randomized Controlled Trial – Annals of Emergency Medicine (link to abstract – $ for full-text)

Commentary on Twitter

TXA wasn't better than placebo in epistaxis in this well done RCT https://t.co/qA3yEXyvaM

Excellent work @adamreuben + team

Many of us (myself included) believed TXA a game changer in epistaxis

This trial must make us reexamine our practice pic.twitter.com/5QQsihlGC6

— Anand Swaminathan (@EMSwami) February 20, 2021

RCT: Five oral analgesics (including opioids) are equally effective for the treatment of acute musculoskeletal extremity pain in the emergency department

21 Feb, 2021 | 21:39h | UTC

A Randomized Trial Comparing the Efficacy of Five Oral Analgesics for Treatment of Acute Musculoskeletal Extremity Pain in the Emergency Department – Annals of Emergency Medicine (link to abstract – $ for full-text)

Commentary on Twitter

Hot off the Press: A Randomized Trial Comparing the Efficacy of
Five Oral Analgesics for Treatment of Acute
Musculoskeletal Extremity Pain in the Emergency
Department https://t.co/qfUNn2TgZM @benjaminbwf pic.twitter.com/BzVM3W5F0L

— AnnalsofEM (@AnnalsofEM) December 30, 2020

RCT: Vitamin D3 does not improve outcomes in hospitalized patients with moderate to severe COVID-19

18 Feb, 2021 | 03:20h | UTC

Effect of a Single High Dose of Vitamin D₃ on Hospital Length of Stay in Patients With Moderate to Severe COVID-19: A Randomized Clinical Trial – JAMA

Editorial: Vitamin D₃ to Treat COVID-19: Different Disease, Same Answer

In this RCT a single high dose of #vitaminD3 (100K IU) raised mean serum 25OH D levels but had no effect on hospital LOS (primary outcome), in-hospital mortality, ICU admission, or need for mechanical ventilation (secondary outcomes) https://t.co/eozVaYnb25

— JAMA (@JAMA_current) February 17, 2021

RCT: Levonorgestrel-releasing intrauterine system vs. endometrial ablation for heavy menstrual bleeding

18 Feb, 2021 | 02:38h | UTC

Levonorgestrel-releasing intrauterine system versus endometrial ablation for heavy menstrual bleeding – American Journal of Obstetrics & Gynecology

RCT: Cemiplimab monotherapy for first-line treatment of advanced non-small-cell lung cancer with PD-L1 of at least 50%

18 Feb, 2021 | 02:34h | UTC

Cemiplimab monotherapy for first-line treatment of advanced non-small-cell lung cancer with PD-L1 of at least 50%: a multicentre, open-label, global, phase 3, randomised, controlled trial – The Lancet

Commentary on Twitter

Phase 3 trial suggests #cemiplimab could be used as new first-line monotherapy option for patients with advanced non-small-cell #lungcancer with PD-L1 of at least 50%—it improved overall & progression-free survival compared with chemotherapy. Read https://t.co/O06Of6wx07 pic.twitter.com/KtQ24lEoR5

— The Lancet (@TheLancet) February 17, 2021

RCT: Among patients with knee osteoarthritis, high-intensity strength training was not associated with better outcomes compared with low-intensity strength training or an attention control

17 Feb, 2021 | 01:24h | UTC

Effect of High-Intensity Strength Training on Knee Pain and Knee Joint Compressive Forces Among Adults With Knee Osteoarthritis: The START Randomized Clinical Trial – JAMA

Commentary: No Benefit from High-Intensity Strength Training for Knee Osteoarthritis – NEJM Journal Watch

Commentary on Twitter

Hot from press: JAMA paper puts question mark on the effectiveness of both low- and high-intensity exercise for knee OA pain. Attention controls had similar improvement. Contextual effects and RTM phenomenon in OA may be powerful! https://t.co/EBrXZcvyXH @OARSInews @JAMA_current pic.twitter.com/880InW1Lag

— Martin Englund (@dr_englund) February 16, 2021

Effect of High-Intensity Strength Training on Knee Pain and Knee Joint Compressive Forces Among Adults With Knee OsteoarthritisThe START Randomized Clinical Trial

👀👀👇👇😳😳https://t.co/W6EQizkiAM pic.twitter.com/RViK36gjHv

— Physio Meets Science (@PhysioMeScience) February 16, 2021

RCT: Short-term outcomes of complete mesocolic excision versus D2 dissection in patients undergoing laparoscopic colectomy for right colon cancer

16 Feb, 2021 | 01:44h | UTC

Short-term outcomes of complete mesocolic excision versus D2 dissection in patients undergoing laparoscopic colectomy for right colon cancer (RELARC): a randomised, controlled, phase 3, superiority trial – The Lancet Oncology (link to abstract – $ for full-text)

How effective is magnesium in for the treatment of migraine?

16 Feb, 2021 | 01:48h | UTC

How Effective is Magnesium in your MAGraine Cocktail? – Journal Feed

Original study: MAGraine: Magnesium compared to conventional therapy for treatment of migraines – American Journal of Emergency Medicine

Opinion: RECOVERY confirms benefit of tocilizumab combined with dexamethasone

16 Feb, 2021 | 02:09h | UTC

PulmCrit – RECOVERY confirms benefit of toci combined with dexamethasone

Original study: RCT: Tocilizumab reduces deaths in patients hospitalized with COVID-19 (study and commentaries)

RCT: Delayed antibiotic prescription feasible for children with uncomplicated respiratory infections

12 Feb, 2021 | 02:02h | UTC

Delayed Antibiotic Prescription for Children With Respiratory Infections: A Randomized Trial – Pediatrics (link to abstract – $ for full-text)

Commentary: Data support delayed antibiotics in kids with respiratory infections – CIDRAP

RCT: Tocilizumab reduces deaths in patients hospitalized with COVID-19

12 Feb, 2021 | 02:25h | UTC

Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): preliminary results of a randomised, controlled, open-label, platform trial – medRxiv

News release: Tocilizumab reduces deaths in patients hospitalised with COVID-19 – University of Oxford

Commentary: Tocilizumab cuts death rate in severe COVID-19, study finds – CIDRAP

Commentary on Twitter

👇RECOVERY pre-print:

Tocilizumab
– reduces mortality
– shortens hospital stay
– reduces progression to invasive mechanical ventilation

Clear benefits on top of corticosteroids

Good news!https://t.co/dal17tQG5b

— Martin Landray (@MartinLandray) February 11, 2021

RCT: Once-weekly, high-dose semaglutide is effective for improving overweight or obesity among non-diabetic adults

11 Feb, 2021 | 02:09h | UTC

Once-Weekly Semaglutide in Adults with Overweight or Obesity – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Semaglutide Plus Lifestyle Change Shown Effective for Obesity – NEJM Journal Watch

Commentary on Twitter

This double-blind study randomly assigned adults with obesity without diabetes to 68 weeks of once-weekly subcutaneous semaglutide or placebo, plus lifestyle intervention. Semaglutide therapy was associated with sustained, clinically relevant weight reduction.

— NEJM (@NEJM) February 10, 2021

Randomized, cross-over trial: Compared to Mediterranean diet, a Low-fat vegan diet is better at improving body weight, lipid concentrations, and insulin sensitivity

11 Feb, 2021 | 01:56h | UTC

A Mediterranean Diet and Low-Fat Vegan Diet to Improve Body Weight and Cardiometabolic Risk Factors: A Randomized, Cross-over Trial – Journal of the American College of Nutrition

Commentary: Vegan diet associated with more weight loss, better cholesterol control than Mediterranean diet – Cardiovascular Business

Commentary on Twitter

36-week randomized cross-over trial:

💥Low-fat plant-based diet reduced body weight, fat mass, and visceral fat, increased insulin sensitivity, and improved blood lipids, compared with a Mediterranean diet.https://t.co/ROJX9WYcix

— Danielle Belardo, MD (@DBelardoMD) February 6, 2021

RCT: The effect of daily protein supplementation, with or without resistance training for 1 year, on muscle size, strength, and function in healthy older adults

11 Feb, 2021 | 01:58h | UTC

The effect of daily protein supplementation, with or without resistance training for 1 year, on muscle size, strength, and function in healthy older adults: A randomized controlled trial – The American Journal of Clinical Nutrition (link to abstract – $ for full-text)

Commentary on Twitter

Daily protein supplementation, with or without resistance training for 1 year, on muscle size, strength, and function in healthy older adults: A randomized controlled trial https://t.co/sT81S8JfNs

No effect of protein supplementation in older persons, but lifting is good!

— Stuart Phillips (@mackinprof) February 10, 2021

RCT: Among patients undergoing transurethral resection of the prostate, it is safe to withhold antimicrobial prophylaxis for those without pre-operative pyuria or a pre-operative, indwelling catheter

11 Feb, 2021 | 01:52h | UTC

Antimicrobial Prophylaxis (AMP) in Transurethral Resection of the Prostate (TURP): Results of a Randomized Trial – The Journal of Urology

Small RCT: Inhaled budesonide reduces the need for hospitalization in COVID-19 patients

11 Feb, 2021 | 02:18h | UTC

Inhaled budesonide in the treatment of early COVID-19 illness: a randomised controlled trial – medRxiv

Commentaries: Common asthma treatment reduces need for hospitalisation in COVID-19 patients, study suggests – University of Oxford AND Expert reaction to preprint on an RCT of inhaled budesonide in the treatment of early COVID-19 – Science Media Centre

RCT: Among patients with acute MI and anemia, a restrictive transfusion strategy resulted in a noninferior rate of major cardiovascular events compared to a liberal transfusion strategy

10 Feb, 2021 | 01:39h | UTC

Effect of a Restrictive vs Liberal Blood Transfusion Strategy on Major Cardiovascular Events Among Patients With Acute Myocardial Infarction and Anemia: The REALITY Randomized Clinical Trial – JAMA (free for a limited period)

Commentary: Restrictive vs. Liberal Blood Transfusion Strategy for MI and Anemia – American College of Cardiology

Commentary on Twitter

Effect of Restrictive vs Liberal Blood Transfusion Strategy on Adults With Myocardial Infarction and Anemia https://t.co/PUtmUj0haw

— JAMA Cardiology (@JAMACardio) February 9, 2021

RCT: In patients with generalized myasthenia gravis prescribed azithromycin, rapid tapering of prednisone is beneficial and safe compared to slow tapering

10 Feb, 2021 | 01:32h | UTC

Comparison of Corticosteroid Tapering Regimens in Myasthenia Gravis: A Randomized Clinical Trial – JAMA Neurology

Commentary on Twitter

Rapid tapering of high-dose #prednisone therapy in patients with moderate to severe generalized #myastheniagravis on azathioprine appears to be well tolerated and associated with good outcome https://t.co/1nHZuy8kPN

— JAMA Neurology (@JAMANeuro) February 8, 2021

RCT: Among children with Myelomeningocele, long term results confirm the benefits of prenatal repair compared to standard postnatal repair

10 Feb, 2021 | 01:28h | UTC

Prenatal Repair and Physical Functioning Among Children With Myelomeningocele: A Secondary Analysis of a Randomized Clinical Trial – JAMA Pediatrics (free for a limited period)

Editorial: Long-term Outcomes of Children After Fetal Surgery for Spina Bifida—Toward Sustainability – JAMA Pediatrics (free for a limited period)

Commentaries: Spina Bifida Repair: The Sooner the Better – Physician’s Weekly AND Prenatal Myelomeningocele Repair Tied to Better Function – HealthDay

Commentary on Twitter

Previous work reported that prenatal versus postnatal repair of myelomeningocele resulted in improved physical functioning. A secondary analysis at #jamapeds reports that these improvements persist into school age. https://t.co/2aehk5L6pi pic.twitter.com/hASLEUcvqm

— JAMA Pediatrics (@JAMAPediatrics) February 9, 2021

RCT: Dobutamine-sparing vs. dobutamine-to-all strategy in cardiac surgery

9 Feb, 2021 | 00:57h | UTC

Dobutamine-sparing versus dobutamine-to-all strategy in cardiac surgery: a randomized noninferiority trial – Annals of Intensive Care

RCT: Total Body Irradiation vs. Chemotherapy Conditioning in Childhood ALL

9 Feb, 2021 | 00:39h | UTC

Total Body Irradiation or Chemotherapy Conditioning in Childhood ALL: A Multinational, Randomized, Noninferiority Phase III Study – Journal of Clinical Oncology

Commentary: TBI Beats Chemoconditioning for ALL Transplants in Children – Medscape (free registration required)

Commentary on Twitter

Total body irradiation or chemotherapy conditioning in childhood acute lymphoblastic leukemia (ALL) — outcomes suggest there's still a role for TBI https://t.co/ICTC0iEGN8 #leusm #pedonc #pedcsm #JCO pic.twitter.com/xARMBlSeni

— ASCO Publications (@ASCO_pubs) December 26, 2020