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Randomized Trials

RCT: Effect of banded Roux-en-Y gastric bypass versus sleeve gastrectomy on diabetes remission at 5 years among patients with obesity and type 2 diabetes.

24 Jun, 2022 | 11:10h | UTC

Effect of Banded Roux-en-Y Gastric Bypass Versus Sleeve Gastrectomy on Diabetes Remission at 5 Years Among Patients With Obesity and Type 2 Diabetes: A Blinded Randomized Clinical Trial – Diabetes Care (link to abstract – $ for full-text)

 


RCT: Effect of MRI-guided fibrosis ablation vs. conventional catheter ablation on atrial arrhythmia recurrence in patients with persistent atrial fibrillation.

23 Jun, 2022 | 12:57h | UTC

Effect of MRI-Guided Fibrosis Ablation vs Conventional Catheter Ablation on Atrial Arrhythmia Recurrence in Patients With Persistent Atrial Fibrillation: The DECAAF II Randomized Clinical Trial – JAMA (free for a limited period)

News Release: Global AFib study finds simple approach is best for ablation procedures – Tulane University

 

Commentary on Twitter

 


RCTs: Once daily oral relugolix combination therapy vs. placebo in patients with endometriosis-associated pain.

23 Jun, 2022 | 10:30h | UTC

Once daily oral relugolix combination therapy versus placebo in patients with endometriosis-associated pain: two replicate phase 3, randomised, double-blind, studies (SPIRIT 1 and 2) – The Lancet

Commentaries:

Relugolix combination therapy for endometriosis pain – The Lancet (free registration required)

Relugolix demonstrates positive phase 3 data as combination therapy for endometriosis pain – Contemporary OB/GYN

 

Commentary on Twitter

 


RCT: Weaning of maintenance immunosuppressive therapy in lupus nephritis.

23 Jun, 2022 | 10:18h | UTC

Weaning of maintenance immunosuppressive therapy in lupus nephritis (WIN-Lupus): results of a multicentre randomised controlled trial – Annals of Rheumatic Diseases

 


RCT: Effect of laparoscopic sleeve gastrectomy vs Roux-en-Y Gastric bypass on weight loss, comorbidities, and reflux at 10 years in adult patients with obesity.

23 Jun, 2022 | 10:17h | UTC

Effect of Laparoscopic Sleeve Gastrectomy vs Roux-en-Y Gastric Bypass on Weight Loss, Comorbidities, and Reflux at 10 Years in Adult Patients With Obesity: The SLEEVEPASS Randomized Clinical Trial – JAMA Surgery (free for a limited period)

 

Commentary on Twitter

 


RCTs: Risankizumab as induction therapy for Crohn’s disease.

23 Jun, 2022 | 10:02h | UTC

Risankizumab as induction therapy for Crohn’s disease: results from the phase 3 ADVANCE and MOTIVATE induction trials – The Lancet (link to abstract – $ for full-text)

Related: Risankizumab as maintenance therapy for moderately to severely active Crohn’s disease: results from the multicentre, randomised, double-blind, placebo-controlled, withdrawal phase 3 FORTIFY maintenance trial – The Lancet (link to abstract – $ for full-text)

 

Commentary on Twitter

 


RCT: Spinal anesthesia is associated with more pain and prescription analgesic use after hip surgery compared to general anesthesia.

22 Jun, 2022 | 12:11h | UTC

News Release: Spinal Anesthesia Associated with More Pain, Prescription Analgesic Use After Hip Surgery Compared with General Anesthesia – American College of Physicians

Study: Pain, Analgesic Use, and Patient Satisfaction With Spinal Versus General Anesthesia for Hip Fracture Surgery: A Randomized Clinical Trial – Annals of Internal Medicine (link to abstract – $ for full-text)

Original Publication: Spinal Anesthesia or General Anesthesia for Hip Surgery in Older Adults – New England Journal of Medicine

Commentary: Spinal Anesthesia Tied to More Severe Pain After Hip Fracture Surgery – HealthDay

Related:

Long-term Survival after Combined Epidural–General Anesthesia or General Anesthesia Alone: Follow-up of a Randomized Trial – Anesthesiology

Delirium in Older Patients after Combined Epidural–General Anesthesia or General Anesthesia for Major Surgery: A Randomized Trial – Anesthesiology

Effect of Regional vs General Anesthesia on Incidence of Postoperative Delirium in Older Patients Undergoing Hip Fracture Surgery: The RAGA Randomized Trial – JAMA

 


RCT: Efficacy and safety of varenicline for smoking cessation in patients with type 2 diabetes.

22 Jun, 2022 | 11:16h | UTC

Efficacy and Safety of Varenicline for Smoking Cessation in Patients With Type 2 Diabetes: A Randomized Clinical Trial – JAMA Network Open

Author Interview: Efficacy and Safety of Varenicline in Patients With Type 2 Diabetes – JAMA

 

Commentary on Twitter

 


RCT: Multispecies probiotic for the prevention of antibiotic-associated diarrhea in children.

22 Jun, 2022 | 11:12h | UTC

Multispecies Probiotic for the Prevention of Antibiotic-Associated Diarrhea in Children: A Randomized Clinical Trial – JAMA Pediatrics (free for a limited period)

Commentary: Mixed Results With Probiotic for Kids’ Antibiotic-Related Diarrhea— Randomized trial misses strictly defined endpoint, but researchers point to benefit – MedPage Today (free registration required)

 

Commentary on Twitter

 


RCT: Modified ligation procedure for prolapsed hemorrhoids vs. stapled hemorrhoidectomy for the management of symptomatic hemorrhoids.

22 Jun, 2022 | 10:59h | UTC

Modified ligation procedure for prolapsed haemorrhoids versus stapled haemorrhoidectomy for the management of symptomatic haemorrhoids (MoLish): randomized clinical trial – BJS Open

 

Commentary on Twitter

 


Phase II RCT: Switch maintenance endocrine therapy plus bevacizumab after bevacizumab plus paclitaxel in advanced or metastatic estrogen receptor-positive, HER2-negative breast cancer.

22 Jun, 2022 | 10:49h | UTC

Switch maintenance endocrine therapy plus bevacizumab after bevacizumab plus paclitaxel in advanced or metastatic oestrogen receptor-positive, HER2-negative breast cancer (BOOSTER): a randomised, open-label, phase 2 trial – The Lancet Oncology (link to abstract – $ for full-text)

Commentary: Switch to Maintenance Endocrine Therapy Plus Bevacizumab After First-Line Paclitaxel/Bevacizumab Induction in Advanced Estrogen Receptor–Positive, HER2-Negative Breast Cancer – The ASCO Post

 


RCT: In people with HIV, treating precancerous anal lesions cuts risk of anal cancer by more than half.

21 Jun, 2022 | 11:11h | UTC

News Release: In people with HIV, treating precancerous anal lesions cuts risk of anal cancer by more than half – National Institutes of Health

Original Study: Treatment of Anal High-Grade Squamous Intraepithelial Lesions to Prevent Anal Cancer – New England Journal of Medicine (link to abstract – $ for full-text)

 

Commentary on Twitter

 


RCT: Guided, internet based, cognitive behavioral therapy noninferior to individual face-to-face CBT for patients with post-traumatic stress disorder.

21 Jun, 2022 | 11:06h | UTC

Guided, internet based, cognitive behavioural therapy for post-traumatic stress disorder: pragmatic, multicentre, randomised controlled non-inferiority trial (RAPID) – The BMJ

 


RCT: Lisocabtagene maraleucel vs. standard of care with salvage chemotherapy followed by autologous stem cell transplantation as second-line treatment in patients with relapsed or refractory large B-cell lymphoma.

21 Jun, 2022 | 10:48h | UTC

Lisocabtagene maraleucel versus standard of care with salvage chemotherapy followed by autologous stem cell transplantation as second-line treatment in patients with relapsed or refractory large B-cell lymphoma (TRANSFORM): results from an interim analysis of an open-label, randomised, phase 3 trial – The Lancet (link to abstract – $ for full-text)

 


RCT: Transfer of thawed frozen embryo versus fresh embryo to improve the healthy baby rate in women undergoing IVF.

21 Jun, 2022 | 10:32h | UTC

Transfer of thawed frozen embryo versus fresh embryo to improve the healthy baby rate in women undergoing IVF: the E-Freeze RCT – Health Technology Assessment

Related: Fresh versus frozen embryo transfers in assisted reproduction – Cochrane Library

 


RCT: Active surveillance plus Enzalutamide monotherapy vs. active surveillance alone in patients with low-risk or intermediate-risk localized prostate cancer.

21 Jun, 2022 | 10:33h | UTC

Active Surveillance Plus Enzalutamide Monotherapy vs Active Surveillance Alone in Patients With Low-risk or Intermediate-risk Localized Prostate Cancer – JAMA Oncology

Invited Commentary: To Treat or Not to Treat Men With Low-risk or Intermediate-risk Prostate Cancer—Weighing the Evidence – JAMA Oncology (free for a limited period)

Video criticizing the article: ENACT trial | A Study That Makes Pharma Rich and Patients’ Poor | I break it down – by Vinay Prasad

 

Commentaries on Twitter

 


Cluster RCT: Evaluation of a multicomponent intervention consisting of education and feedback to reduce benzodiazepine prescriptions by general practitioners.

21 Jun, 2022 | 10:29h | UTC

Evaluation of a multicomponent intervention consisting of education and feedback to reduce benzodiazepine prescriptions by general practitioners: The BENZORED hybrid type 1 cluster randomized controlled trial – PLOS One

 


RCT: Immune enhancement with Thymosin alpha 1 does not improve outcomes in patients with predicted severe acute necrotizing pancreatitis.

20 Jun, 2022 | 01:11h | UTC

Immune enhancement in patients with predicted severe acute necrotising pancreatitis: a multicentre double-blind randomised controlled trial – Intensive Care Medicine (if the link is paywalled, try this one)

 


RCT: Safety and efficacy of Eptinezumab for migraine prevention in patients with two-to-four previous preventive treatment failures.

20 Jun, 2022 | 01:01h | UTC

Safety and efficacy of eptinezumab for migraine prevention in patients with two-to-four previous preventive treatment failures (DELIVER): a multi-arm, randomised, double-blind, placebo-controlled, phase 3b trial – The Lancet Neurology (link to abstract – $ for full-text)

 


#CCR22 – RCT: Intravenous Vitamin C increases the risk of death or persistent organ dysfunction in adults with sepsis in the intensive care unit.

16 Jun, 2022 | 11:13h | UTC

Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit – New England Journal of Medicine

Related:

Effect of adjunctive vitamin C, glucocorticoids, and vitamin B1 on longer-term mortality in adults with sepsis or septic shock: a systematic review and a component network meta-analysis – Intensive Care Medicine

Effect of Vitamin C, Thiamine, and Hydrocortisone on Ventilator- and Vasopressor-Free Days in Patients With Sepsis: The VICTAS Randomized Clinical Trial – JAMA

Effect of Vitamin C, Hydrocortisone, and Thiamine vs Hydrocortisone Alone on Time Alive and Free of Vasopressor Support Among Patients With Septic Shock: The VITAMINS Randomized Clinical Trial – JAMA

 

Commentary on Twitter

 


RCT: Discontinuation of Infliximab therapy in patients with Crohn’s disease.

15 Jun, 2022 | 10:54h | UTC

Discontinuation of Infliximab Therapy in Patients with Crohn’s Disease – NEJM Evidence

 


RCT: Marine Omega-3 Fatty acid supplementation does not reduce the incidence of dry eye disease in healthy adults.

10 Jun, 2022 | 12:25h | UTC

Efficacy of Marine ω-3 Fatty Acid Supplementation vs Placebo in Reducing Incidence of Dry Eye Disease in Healthy US Adults: A Randomized Clinical Trial – JAMA Ophthalmology (free for a limited period)

Invited Commentary: Another Disappointment for ω-3 Fatty Acid and Dry Eye Disease – JAMA Ophthalmology (free for a limited period)

 

Commentary on Twitter

 


Neck circumference measurement for surveillance and early detection of hemorrhage after thyroidectomy: a diagnostic accuracy study.

10 Jun, 2022 | 11:39h | UTC

Neck Circumference Measurement for Surveillance and Early Detection of Hemorrhage After Thyroidectomy: A Diagnostic Accuracy Study – JAMA Otolaryngology-Head & Neck Surgery (free for a limited period)

 

Commentary on Twitter

 


RCT: Effect of electronic symptom monitoring on patient-reported outcomes among patients with metastatic cancer.

8 Jun, 2022 | 11:14h | UTC

Effect of Electronic Symptom Monitoring on Patient-Reported Outcomes Among Patients With Metastatic Cancer: A Randomized Clinical Trial – JAMA (free for a limited period)

Related:

Digital remote monitoring plus usual care versus usual care in patients treated with oral anticancer agents: the randomized phase 3 CAPRI trial – Nature Medicine (if the link is paywalled, try this one)

Key components of successful digital remote monitoring in oncology – Nature Medicine

Electronic Health Interventions for Patients With Breast Cancer: Systematic Review and Meta-Analyses – Journal of Clinical Oncology

Efficiency of Electronic Health Record Assessment of Patient-Reported Outcomes After Cancer Immunotherapy: A Randomized Clinical Trial – JAMA Network Open

 


Do we need to reconsider how we design and conduct randomized controlled trials?

8 Jun, 2022 | 10:56h | UTC

Do we need to reconsider how we design and conduct randomized controlled trials? – European Heart Journal – Quality of Care and Clinical Outcomes

 


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