Open access
Open access
Powered by Google Translator Translator

Randomized Trials

RCT | Pelvic floor rehabilitation after rectal cancer surgery.

26 Sep, 2022 | 12:04h | UTC

Pelvic Floor Rehabilitation After Rectal Cancer Surgery: A Multicenter Randomized Clinical Trial (FORCE Trial) – Annals of Surgery

 


RCT | Outpatient vs. inpatient preinduction cervical ripening using a synthetic osmotic dilator.

26 Sep, 2022 | 11:58h | UTC

Outpatient Compared With Inpatient Preinduction Cervical Ripening Using a Synthetic Osmotic Dilator: A Randomized Clinical Trial – Obstetrics & Gynecology

 


RCT | 6-year results of primary selective laser trabeculoplasty vs. eye drops for glaucoma and ocular hypertension.

23 Sep, 2022 | 13:06h | UTC

LiGHT trial: 6-year results of primary selective laser trabeculoplasty versus eye drops for the treatment of glaucoma and ocular hypertension – Ophthalmology

Original Study: Randomized Trial: Selective Laser Trabeculoplasty vs. Eye Drops for First-line Treatment of Ocular Hypertension and Glaucoma

 


Secondary analysis of a RCT | Complete revascularization vs. culprit lesion–only PCI for angina-related quality of life in patients with STEMI.

22 Sep, 2022 | 13:17h | UTC

Complete Revascularization vs Culprit Lesion–Only Percutaneous Coronary Intervention for Angina-Related Quality of Life in Patients With ST-Segment Elevation Myocardial Infarction: Results From the COMPLETE Randomized Clinical Trial – JAMA Cardiology (link to abstract – $ for full-text)

Original Study: #ESCCongress – Randomized Trial: Complete Revascularization Superior to Culprit-lesion-only PCI in Patients with ST-segment Elevation Myocardial Infarction (STEMI) and Multivessel Coronary Artery Disease

Related meta-analysis:

Meta-analysis: multivessel versus culprit-only revascularization in STEMI and multivessel coronary artery disease

Meta-Analysis: Complete vs. Culprit-Lesion-Only Revascularization for ST-Segment Elevation Myocardial Infarction

Study: Nonculprit-lesion PCI Timing in Patients With ST-Segment Elevation Myocardial Infarction

Studies in patients with cardiogenic shock:

PCI Strategies in Patients with Acute Myocardial Infarction and Cardiogenic Shock – New England Journal of Medicine

One-Year Outcomes after PCI Strategies in Cardiogenic Shock – New England Journal of Medicine

 


RCT | Effect of Tocilizumab on disease activity in patients with active polymyalgia rheumatica receiving glucocorticoid therapy.

22 Sep, 2022 | 13:06h | UTC

Effect of Tocilizumab on Disease Activity in Patients With Active Polymyalgia Rheumatica Receiving Glucocorticoid Therapy: A Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Tocilizumab as a Novel Therapy for Steroid-Dependent Polymyalgia Rheumatica – JAMA (free for a limited period)

Video Editor’s Note: Tocilizumab and Disease Activity in Patients With Polymyalgia Rheumatica Receiving Glucocorticoid Therapy – JAMA

 


RCTs | Effect of Roflumilast cream vs. vehicle cream on chronic plaque psoriasis.

22 Sep, 2022 | 13:06h | UTC

Effect of Roflumilast Cream vs Vehicle Cream on Chronic Plaque Psoriasis: The DERMIS-1 and DERMIS-2 Randomized Clinical Trials – JAMA (free for a limited period)

Editorial: Roflumilast for Chronic Plaque Psoriasis – JAMA

Commentary: Study Suggests Roflumilast May Be Effective As Treatment For Plaque Psoriasis – HCPLive

 

Commentary on Twitter

 


RCT | Effect of clinical decision support with audit and feedback on prevention of acute kidney injury in patients undergoing coronary angiography.

22 Sep, 2022 | 13:04h | UTC

Effect of Clinical Decision Support With Audit and Feedback on Prevention of Acute Kidney Injury in Patients Undergoing Coronary Angiography: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Commentary: Intervention Cuts Risk for AKI After Coronary Angiography – HealthDay

 

Commentary on Twitter

 


RCT | Effect of the family-centered advance care planning for teens with cancer intervention on sustainability of congruence about end-of-life treatment preferences.

22 Sep, 2022 | 13:02h | UTC

Effect of the Family-Centered Advance Care Planning for Teens with Cancer Intervention on Sustainability of Congruence About End-of-Life Treatment Preferences: A Randomized Clinical Trial – JAMA Network Open

News Release: Advance care planning for adolescents with cancer – University of Minnesota

Commentary: Study Examines Effects of Advance Care Planning for Adolescents With Cancer – The ASCO Post

 

Commentary on Twitter

 


RCT | Routine ultrasonography guidance for femoral vascular access for cardiac procedures improved first-pass success but did not reduce complications.

22 Sep, 2022 | 13:01h | UTC

Routine Ultrasonography Guidance for Femoral Vascular Access for Cardiac Procedures: The UNIVERSAL Randomized Clinical Trial – JAMA Cardiology (free for a limited period)

Commentary: Fluoroscopic Guidance for Femoral Artery Access—Pushing Patients Out of the Plane Without a Parachute? – JAMA Cardiology

 


RCT | Circular stapled technique vs. modified collard technique for cervical esophagogastric anastomosis after esophagectomy.

21 Sep, 2022 | 13:08h | UTC

Circular Stapled Technique Versus Modified Collard Technique for Cervical Esophagogastric Anastomosis After Esophagectomy: A Randomized Controlled Trial – Annals of Surgery (link to abstract – $ for full-text)

 


RCT | Efficacy and safety of Rituximab for new onset generalized Myasthenia Gravis.

21 Sep, 2022 | 13:04h | UTC

Efficacy and Safety of Rituximab for New-Onset Generalized Myasthenia Gravis: The RINOMAX Randomized Clinical Trial – JAMA Neurology

 

Commentary on Twitter

 


RCTs | Crenezumab not beneficial for patients with early Alzheimer Disease.

21 Sep, 2022 | 13:03h | UTC

Evaluating the Safety and Efficacy of Crenezumab vs Placebo in Adults With Early Alzheimer Disease: Two Phase 3 Randomized Placebo-Controlled Trials – JAMA Neurology

 


Long-term follow-up of a RCT | Percutaneous coronary intervention vs. bypass surgery for multivessel coronary artery disease.

20 Sep, 2022 | 13:34h | UTC

Everolimus-Eluting Stents or Bypass Surgery for Multivessel Coronary Artery Disease: Extended Follow-up Outcomes of Multicenter Randomized Controlled BEST Trial – Circulation

Commentary: 10-Year Data From BEST Trial Find No Significant Safety or MACE Differences Between PCI With EES Versus CABG – Cardiac Interventions Today

Original Study: Trial of Everolimus-Eluting Stents or Bypass Surgery for Coronary Disease – New England Journal of Medicine

 


Long-term follow-up of a RCT | Outcomes after catheter-based renal artery denervation for resistant hypertension.

20 Sep, 2022 | 13:33h | UTC

Long-term outcomes after catheter-based renal artery denervation for resistant hypertension: final follow-up of the randomised SYMPLICITY HTN-3 Trial – The Lancet (free registration required)

Commentary: SYMPLICITY HTN-3’s Late Surprise: Sustained BP Drop at 3 Years Despite Earlier Miss – TCTMD

Original Study: A Controlled Trial of Renal Denervation for Resistant Hypertension – New England Journal of Medicine

 


RCT | Myopia control effect of repeated low-level red-light therapy in children.

20 Sep, 2022 | 13:31h | UTC

Myopia Control Effect of Repeated Low-Level Red-Light Therapy in Chinese Children: A Randomized, Double-Blind, Controlled Clinical Trial – Ophthalmology

Commentary: Repeated Low-Level Red-Light Therapy Reduces Myopia Progression in Children – HCP Live

 


Preliminary results of a RCT | Once-only colonoscopy vs. two rounds of fecal immunochemical testing 2 years apart for colorectal cancer screening.

20 Sep, 2022 | 13:29h | UTC

Once-only colonoscopy or two rounds of faecal immunochemical testing 2 years apart for colorectal cancer screening (SCREESCO): preliminary report of a randomised controlled trial – The Lancet Gastroenterology & Hepatology (link to abstract – $ for full-text)

Commentary: Two Rounds of FIT vs Single Colonoscopy as a One-time CRC Screening – Medscape (free registration required)

 


RCT | Dupilumab in children aged 6 months to younger than 6 years with uncontrolled atopic dermatitis.

20 Sep, 2022 | 13:20h | UTC

Dupilumab in children aged 6 months to younger than 6 years with uncontrolled atopic dermatitis: a randomised, double-blind, placebo-controlled, phase 3 trial – The Lancet

Commentary: Dupilumab Eases Atopic Dermatitis in Children Younger Than 6 Years – HealthDay

 


RCT | Deucravacitinib vs. placebo and Apremilast in moderate to severe plaque psoriasis.

20 Sep, 2022 | 13:16h | UTC

Deucravacitinib versus placebo and apremilast in moderate to severe plaque psoriasis: efficacy and safety results from the 52-week, randomized, double-blinded, phase 3 POETYK PSO-2 trial – Journal of the American Academy of Dermatology

 


RCT | Cerebral embolic protection during transcatheter aortic-valve replacement did not significantly reduce the incidence of periprocedural stroke.

19 Sep, 2022 | 12:49h | UTC

Cerebral Embolic Protection during Transcatheter Aortic-Valve Replacement – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries:

PROTECTED TAVR: No Less Stroke With Embolic Protection, but Some See Hope – TCTMD

Stroke PROTECTion With SEntinel During Transcatheter Aortic Valve Replacement – PROTECTED TAVR – American College of Cardiology

Presumed Clinical Benefits of TAVR Cerebral Protection Remain Unproven — Large trial comes up short in proving a definitive benefit to debris filters – MedPage Today (free registration required)

News Release: Cerebral Embolic Protection During Transcatheter Aortic-Valve Replacement – Cedars-Sinai

 

Commentary on Twitter

 


RCT | Methotrexate may increase response rates in patients with uncontrolled gout receiving Pegloticase.

19 Sep, 2022 | 12:38h | UTC

A Randomized Placebo-Controlled Study of Methotrexate to Increase Response Rates in Patients with Uncontrolled GOut Receiving Pegloticase (MIRROR RCT): Primary Efficacy and Safety Findings – Arthritis & Rheumatology

Commentary: Data Now Out for Pegloticase-MTX Combo Gout Treatment – MedPage Today (free registration required)

 


RCT | Olokizumab, a monoclonal antibody against interleukin-6, in combination with methotrexate in patients with rheumatoid arthritis inadequately controlled by tumor necrosis factor inhibitor therapy.

19 Sep, 2022 | 12:35h | UTC

Olokizumab, a monoclonal antibody against interleukin-6, in combination with methotrexate in patients with rheumatoid arthritis inadequately controlled by tumour necrosis factor inhibitor therapy: efficacy and safety results of a randomised controlled phase III study – Annals of Rheumatic Diseases

 


Phase 2 RCT | Combined nivolumab and ipilimumab with or without stereotactic body radiation therapy for advanced Merkel cell carcinoma.

19 Sep, 2022 | 12:32h | UTC

Combined nivolumab and ipilimumab with or without stereotactic body radiation therapy for advanced Merkel cell carcinoma: a randomised, open label, phase 2 trial – The Lancet (free registration required for full-text)

Commentary: Dual checkpoint inhibitor blockade shows promise as first-line and salvage therapy for Merkel cell carcinoma patients – H. Lee Moffitt Cancer Center & Research Institute

 


RCT | Intensity-modulated radiotherapy vs. stereotactic body radiotherapy for prostate cancer.

19 Sep, 2022 | 12:31h | UTC

Intensity-modulated radiotherapy versus stereotactic body radiotherapy for prostate cancer (PACE-B): 2-year toxicity results from an open-label, randomised, phase 3, non-inferiority trial – The Lancet Oncology (link to abstract – $ for full-text)

 

Commentary from the author on Twitter (thread – click for more)

 


RCT | Short-term outcomes of laparoscopy-assisted vs. open surgery for patients with low rectal cancer.

16 Sep, 2022 | 12:58h | UTC

Short-term Outcomes of Laparoscopy-Assisted vs Open Surgery for Patients With Low Rectal Cancer: The LASRE Randomized Clinical Trial – JAMA Oncology

 

Commentary on Twitter

 


RCT | In patients with acute pancreatitis, early aggressive hydration resulted in a higher incidence of fluid overload without improvement in clinical outcomes.

15 Sep, 2022 | 13:15h | UTC

Aggressive or Moderate Fluid Resuscitation in Acute Pancreatitis – New England Journal of Medicine (link to abstract – $ for full-text)

 


Stay Updated in Your Specialty

No spam, just news.