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Randomized Trials

RCT | Sodium bicarbonate over 2 years was not beneficial for kidney transplant recipients with metabolic acidosis

27 Jan, 2023 | 12:23h | UTC

Sodium bicarbonate for kidney transplant recipients with metabolic acidosis in Switzerland: a multicentre, randomised, single-blind, placebo-controlled, phase 3 trial – The Lancet (link to abstract – $ for full-text)

 


RCT | High-dose steroid in low pain responders undergoing total knee arthroplasty

27 Jan, 2023 | 12:08h | UTC

High-dose steroid in low pain responders undergoing total knee arthroplasty: a randomised double-blind trial – British Journal of Anaesthesia

 


RCT | Duration of prophylactic levetiracetam after surgery for brain tumor

27 Jan, 2023 | 12:06h | UTC

Duration of Prophylactic Levetiracetam After Surgery for Brain Tumor: A Prospective Randomized Trial – Neurosurgery

 

Commentary on Twitter

 


M-A | Microsurgery vs. microsurgery with preoperative embolization for brain arteriovenous malformation treatment

27 Jan, 2023 | 12:05h | UTC

Microsurgery versus Microsurgery With Preoperative Embolization for Brain Arteriovenous Malformation Treatment: A Systematic Review and Meta-analysis – Neurosurgery

 


RCT | Shoulder stretching vs. shoulder muscle strength training for the prevention of baseball-related arm injuries

27 Jan, 2023 | 11:57h | UTC

Shoulder stretching versus shoulder muscle strength training for the prevention of baseball-related arm injuries: a randomized, active-controlled, open-label, non-inferiority study – Scientific Reports

 

Commentary on Twitter

 


RCT | Curettage plus platelet-rich plasma gel vs. curettage plus phenol application in treatment of pilonidal sinus disease

26 Jan, 2023 | 12:05h | UTC

Comparison of Curettage Plus Platelet-Rich Plasma Gel and Curettage Plus Phenol Application in Treatment of Pilonidal Sinus Disease: A Randomized Trial – Diseases of the Colon & Rectum (link to abstract – $ for full-text)

See also: Visual Abstract

 


RCT | Postoperative adjuvant hepatic arterial infusion chemotherapy with FOLFOX in hepatocellular carcinoma with microvascular invasion

26 Jan, 2023 | 12:03h | UTC

Postoperative Adjuvant Hepatic Arterial Infusion Chemotherapy With FOLFOX in Hepatocellular Carcinoma With Microvascular Invasion: A Multicenter, Phase III, Randomized Study – Journal of Clinical Oncology

 


RCT | Preoperative chemotherapy reduced recurrence in operable colon cancer

25 Jan, 2023 | 11:29h | UTC

Preoperative Chemotherapy for Operable Colon Cancer: Mature Results of an International Randomized Controlled Trial – Journal of Clinical Oncology

Editorial: FOxTROT: Are We Ready to Dance? – Journal of Clinical Oncology

News Release: Chemotherapy before surgery cuts risk of colon cancer returning, trial finds – Cancer Research UK

Commentary: New treatment strategy cuts risk of bowel cancer returning by 28% – The Guardian

 

Commentary from one of the authors on Twitter (thread – click for more)

 


RCT | Monitoring of cerebral tissue oxygen saturation to guide oxygen delivery in preterm neonates did not improve outcomes

25 Jan, 2023 | 11:23h | UTC

Cerebral regional tissue Oxygen Saturation to Guide Oxygen Delivery in preterm neonates during immediate transition after birth (COSGOD III): multicentre randomised phase 3 clinical trial – The BMJ

 


RCT | 2 days of postoperative antibiotics is noninferior to 5 days in patients with complex appendicitis

24 Jan, 2023 | 14:33h | UTC

2 days versus 5 days of postoperative antibiotics for complex appendicitis: a pragmatic, open-label, multicentre, non-inferiority randomised trial – The Lancet (link to abstract – $ for full-text)

Commentary: Trial supports shorter postoperative antibiotics for complex appendicitis – CIDRAP

 

Commentary on Twitter

 


RCT | Intracorporeal vs. extracorporeal anastomosis in robotic right colectomy

24 Jan, 2023 | 14:17h | UTC

Intracorporeal Versus Extracorporeal Anastomosis in Robotic Right Colectomy: A Multicenter, Triple-blind, Randomized Clinical Trial – Annals of Surgery (link to abstract – $ for full-text)

 


RCT | Standard threshold laser versus subthreshold micropulse laser for adults with diabetic macular edema

24 Jan, 2023 | 14:02h | UTC

Standard threshold laser versus subthreshold micropulse laser for adults with diabetic macular oedema: the DIAMONDS non-inferiority RCT – Health Technology Assessment

Original Publication: Diabetic Macular Edema and Diode Subthreshold Micropulse Laser: A Randomized Double-Masked Noninferiority Clinical Trial – Ophthalmology

 


RCT | Effects of a web-guided system for self-treatment of recurrent benign paroxysmal positional vertigo

23 Jan, 2023 | 13:43h | UTC

Effect of Self-treatment of Recurrent Benign Paroxysmal Positional Vertigo: A Randomized Clinical Trial – JAMA Neurology (free for a limited period)

Related Video: Web-Guided Canalith Reposition Maneuver – JAMA

Commentary: Web-Based System Works Well for Diagnosis, Treatment of Recurrent Vertigo – HealthDay

 

Commentary on Twitter

 


RCT | Adjuvant S-1 compared with observation in resected biliary tract cancer

23 Jan, 2023 | 13:24h | UTC

Adjuvant S-1 compared with observation in resected biliary tract cancer (JCOG1202, ASCOT): a multicentre, open-label, randomised, controlled, phase 3 trial – The Lancet (link to abstract – $ for full-text)

 

Commentary on Twitter

 


RCT | Small study suggests hybrid ablation is more effective than repeated catheter ablation in persistent atrial fibrillation

23 Jan, 2023 | 13:23h | UTC

Hybrid Ablation Versus Repeated Catheter Ablation in Persistent Atrial Fibrillation: A Randomized Controlled Trial – JACC: Clinical Electrophysiology

Commentary: Hybrid Versus Catheter Ablation in Persistent Atrial Fibrillation – HARTCAP-AF – American College of Cardiology

 


RCT | Oral ibuprofen and oral ketorolac are similarly effective for children with acute traumatic pain

20 Jan, 2023 | 14:47h | UTC

Oral ibuprofen versus oral ketorolac for children with moderate and severe acute traumatic pain: a randomized comparative study – European Journal of Pediatrics

 


RCT | Routine use of endometrial receptivity testing to guide the timing of frozen embryo transfer did not improve the rates of live birth

20 Jan, 2023 | 14:45h | UTC

Effect of Timing by Endometrial Receptivity Testing vs Standard Timing of Frozen Embryo Transfer on Live Birth in Patients Undergoing In Vitro Fertilization: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

 

Commentary on Twitter

 


An overview of methodological considerations regarding adaptive stopping, arm dropping, and randomization in clinical trials

20 Jan, 2023 | 14:27h | UTC

An overview of methodological considerations regarding adaptive stopping, arm dropping, and randomization in clinical trials – Journal of Clinical Epidemiology

 

Commentary from the author on Twitter

Under a Creative Commons Attribution (CC BY 4.0) License

 


RCT | Bilateral ultrasound-guided erector spinae plane block vs. wound infiltration for postoperative analgesia in lumbar spinal fusion surgery

20 Jan, 2023 | 14:18h | UTC

Bilateral ultrasound-guided erector spinae plane block versus wound infiltration for postoperative analgesia in lumbar spinal fusion surgery: a randomized controlled trial – European Spine Journal

Commentary: Bilateral USG-guided ESP block decreases short-term opioid consumption after lumbar spinal fusion surgery – Medical Dialogues

 


RCT | No difference in survival with Torsemide vs. Furosemide after discharge of patients hospitalized with heart failure

19 Jan, 2023 | 14:26h | UTC

Effect of Torsemide vs Furosemide After Discharge on All-Cause Mortality in Patients Hospitalized With Heart Failure: The TRANSFORM-HF Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: TRANSFORM-HF—Can We Close the Loop on Diuretics in Heart Failure? – JAMA (free for a limited period)

News Release: Comparison of diuretics shows no difference in heart failure survival – NIH/National Heart, Lung and Blood Institute

 

Commentary on Twitter

 


RCT | SPONGE-assisted vs. Trendelenburg position surgery in laparoscopic sigmoid and rectal cancer surgery

19 Jan, 2023 | 14:06h | UTC

SPONGE-assisted vs. Trendelenburg position surgery in laparoscopic sigmoid and rectal cancer surgery (SPONGE trial): randomized clinical trial – British Journal of Surgery (link to abstract – $ for full-text)

 


RCT | Bimekizumab in patients with active psoriatic arthritis and previous inadequate response or intolerance to TNFα inhibitors

19 Jan, 2023 | 14:05h | UTC

Bimekizumab in patients with active psoriatic arthritis and previous inadequate response or intolerance to tumour necrosis factor-α inhibitors: a randomised, double-blind, placebo-controlled, phase 3 trial (BE COMPLETE) – The Lancet

Related Study: Bimekizumab in patients with psoriatic arthritis, naive to biologic treatment: a randomised, double-blind, placebo-controlled, phase 3 trial (BE OPTIMAL) – The Lancet

 


RCT | Effectiveness of an intervention to improve decision making for older patients with advanced CKD

19 Jan, 2023 | 14:04h | UTC

Effectiveness of an Intervention to Improve Decision Making for Older Patients With Advanced Chronic Kidney Disease: A Randomized Controlled Trial – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentary: Digital decision aid may be useful for older adults with CKD – ACP Internist

 

Commentary on Twitter

 


RCT | Prevention of incisional hernias by prophylactic mesh-augmented reinforcement of midline laparotomies for AAA treatment

19 Jan, 2023 | 14:03h | UTC

Prevention of Incisional Hernias by Prophylactic Mesh-augmented Reinforcement of Midline Laparotomies for Abdominal Aortic Aneurysm Treatment: Five-year Follow-up of a Randomized Controlled Trial – Annals of Surgery

 


RCT | Aqueous povidone-iodine vs. normal saline for intraoperative wound irrigation on the incidence of SSI after GI surgery

19 Jan, 2023 | 13:54h | UTC

Aqueous Povidone-Iodine Versus Normal Saline For Intraoperative Wound Irrigation On The Incidence Of Surgical Site Infection In Clean-Contaminated Wounds After Gastroenterological Surgery: A Single Institute, Prospective, Blinded-Endpoint, Randomized Controlled Trial – Annals of Surgery (link to abstract – $ for full-text)

 


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