Randomized Trials
RCT | Pelvic floor rehabilitation after rectal cancer surgery.
26 Sep, 2022 | 12:04h | UTC
RCT | Outpatient vs. inpatient preinduction cervical ripening using a synthetic osmotic dilator.
26 Sep, 2022 | 11:58h | UTC
RCT | 6-year results of primary selective laser trabeculoplasty vs. eye drops for glaucoma and ocular hypertension.
23 Sep, 2022 | 13:06h | UTCOriginal Study: Randomized Trial: Selective Laser Trabeculoplasty vs. Eye Drops for First-line Treatment of Ocular Hypertension and Glaucoma
Secondary analysis of a RCT | Complete revascularization vs. culprit lesion–only PCI for angina-related quality of life in patients with STEMI.
22 Sep, 2022 | 13:17h | UTCComplete Revascularization vs Culprit Lesion–Only Percutaneous Coronary Intervention for Angina-Related Quality of Life in Patients With ST-Segment Elevation Myocardial Infarction: Results From the COMPLETE Randomized Clinical Trial – JAMA Cardiology (link to abstract – $ for full-text)
Related meta-analysis:
Study: Nonculprit-lesion PCI Timing in Patients With ST-Segment Elevation Myocardial Infarction
Studies in patients with cardiogenic shock:
One-Year Outcomes after PCI Strategies in Cardiogenic Shock – New England Journal of Medicine
RCT | Effect of Tocilizumab on disease activity in patients with active polymyalgia rheumatica receiving glucocorticoid therapy.
22 Sep, 2022 | 13:06h | UTCEffect of Tocilizumab on Disease Activity in Patients With Active Polymyalgia Rheumatica Receiving Glucocorticoid Therapy: A Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Tocilizumab as a Novel Therapy for Steroid-Dependent Polymyalgia Rheumatica – JAMA (free for a limited period)
Video Editor’s Note: Tocilizumab and Disease Activity in Patients With Polymyalgia Rheumatica Receiving Glucocorticoid Therapy – JAMA
RCTs | Effect of Roflumilast cream vs. vehicle cream on chronic plaque psoriasis.
22 Sep, 2022 | 13:06h | UTCEffect of Roflumilast Cream vs Vehicle Cream on Chronic Plaque Psoriasis: The DERMIS-1 and DERMIS-2 Randomized Clinical Trials – JAMA (free for a limited period)
Editorial: Roflumilast for Chronic Plaque Psoriasis – JAMA
Commentary: Study Suggests Roflumilast May Be Effective As Treatment For Plaque Psoriasis – HCPLive
Commentary on Twitter
Roflumilast cream resulted in better chronic plaque psoriasis clinical status compared with vehicle cream at 8 weeks; further research is needed to compare efficacy with other active treatments and to assess longer-term efficacy and safety. https://t.co/DyGNNjr5ea #Research pic.twitter.com/QnMcChnht6
— JAMA (@JAMA_current) September 21, 2022
RCT | Effect of clinical decision support with audit and feedback on prevention of acute kidney injury in patients undergoing coronary angiography.
22 Sep, 2022 | 13:04h | UTCEffect of Clinical Decision Support With Audit and Feedback on Prevention of Acute Kidney Injury in Patients Undergoing Coronary Angiography: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)
Commentary: Intervention Cuts Risk for AKI After Coronary Angiography – HealthDay
Commentary on Twitter
This multifaceted intervention led to a lower risk of acute kidney injury in patients undergoing coronary angiography, percutaneous coronary intervention, or both. #Research https://t.co/rKVBsRxHy7
— JAMA (@JAMA_current) September 7, 2022
RCT | Effect of the family-centered advance care planning for teens with cancer intervention on sustainability of congruence about end-of-life treatment preferences.
22 Sep, 2022 | 13:02h | UTCNews Release: Advance care planning for adolescents with cancer – University of Minnesota
Commentary: Study Examines Effects of Advance Care Planning for Adolescents With Cancer – The ASCO Post
Commentary on Twitter
Results of this trial showed that, for those who received the FACE®-TC intervention, the families’ knowledge of their adolescents’ end-of-life treatment preferences was sustained for 1 year, suggesting yearly follow-up sessions. @ChildrensNatl #EOL https://t.co/dngUhFQ5vQ
— JAMA Network Open (@JAMANetworkOpen) July 12, 2022
RCT | Routine ultrasonography guidance for femoral vascular access for cardiac procedures improved first-pass success but did not reduce complications.
22 Sep, 2022 | 13:01h | UTCRoutine Ultrasonography Guidance for Femoral Vascular Access for Cardiac Procedures: The UNIVERSAL Randomized Clinical Trial – JAMA Cardiology (free for a limited period)
RCT | Circular stapled technique vs. modified collard technique for cervical esophagogastric anastomosis after esophagectomy.
21 Sep, 2022 | 13:08h | UTCCircular Stapled Technique Versus Modified Collard Technique for Cervical Esophagogastric Anastomosis After Esophagectomy: A Randomized Controlled Trial – Annals of Surgery (link to abstract – $ for full-text)
RCT | Efficacy and safety of Rituximab for new onset generalized Myasthenia Gravis.
21 Sep, 2022 | 13:04h | UTC
Commentary on Twitter
Treatment with #rituximab shortly after onset of #myastheniagravis was effective, a placebo-controlled randomized study showed. https://t.co/wdUzx7yOq6 #Research
— JAMA Neurology (@JAMANeuro) September 19, 2022
RCTs | Crenezumab not beneficial for patients with early Alzheimer Disease.
21 Sep, 2022 | 13:03h | UTC
Long-term follow-up of a RCT | Percutaneous coronary intervention vs. bypass surgery for multivessel coronary artery disease.
20 Sep, 2022 | 13:34h | UTCOriginal Study: Trial of Everolimus-Eluting Stents or Bypass Surgery for Coronary Disease – New England Journal of Medicine
Long-term follow-up of a RCT | Outcomes after catheter-based renal artery denervation for resistant hypertension.
20 Sep, 2022 | 13:33h | UTCLong-term outcomes after catheter-based renal artery denervation for resistant hypertension: final follow-up of the randomised SYMPLICITY HTN-3 Trial – The Lancet (free registration required)
Commentary: SYMPLICITY HTN-3’s Late Surprise: Sustained BP Drop at 3 Years Despite Earlier Miss – TCTMD
Original Study: A Controlled Trial of Renal Denervation for Resistant Hypertension – New England Journal of Medicine
RCT | Myopia control effect of repeated low-level red-light therapy in children.
20 Sep, 2022 | 13:31h | UTCCommentary: Repeated Low-Level Red-Light Therapy Reduces Myopia Progression in Children – HCP Live
Preliminary results of a RCT | Once-only colonoscopy vs. two rounds of fecal immunochemical testing 2 years apart for colorectal cancer screening.
20 Sep, 2022 | 13:29h | UTCOnce-only colonoscopy or two rounds of faecal immunochemical testing 2 years apart for colorectal cancer screening (SCREESCO): preliminary report of a randomised controlled trial – The Lancet Gastroenterology & Hepatology (link to abstract – $ for full-text)
Commentary: Two Rounds of FIT vs Single Colonoscopy as a One-time CRC Screening – Medscape (free registration required)
RCT | Dupilumab in children aged 6 months to younger than 6 years with uncontrolled atopic dermatitis.
20 Sep, 2022 | 13:20h | UTCCommentary: Dupilumab Eases Atopic Dermatitis in Children Younger Than 6 Years – HealthDay
RCT | Deucravacitinib vs. placebo and Apremilast in moderate to severe plaque psoriasis.
20 Sep, 2022 | 13:16h | UTC
RCT | Cerebral embolic protection during transcatheter aortic-valve replacement did not significantly reduce the incidence of periprocedural stroke.
19 Sep, 2022 | 12:49h | UTCCerebral Embolic Protection during Transcatheter Aortic-Valve Replacement – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries:
PROTECTED TAVR: No Less Stroke With Embolic Protection, but Some See Hope – TCTMD
Presumed Clinical Benefits of TAVR Cerebral Protection Remain Unproven — Large trial comes up short in proving a definitive benefit to debris filters – MedPage Today (free registration required)
News Release: Cerebral Embolic Protection During Transcatheter Aortic-Valve Replacement – Cedars-Sinai
Commentary on Twitter
In a randomized trial involving patients with aortic stenosis, the use of a cerebral protection device during TAVR did not decrease the risk of periprocedural stroke, but there were fewer disabling strokes. #TCT2022 https://t.co/wBgNlgmIty pic.twitter.com/EViLG19shX
— NEJM (@NEJM) September 17, 2022
RCT | Methotrexate may increase response rates in patients with uncontrolled gout receiving Pegloticase.
19 Sep, 2022 | 12:38h | UTCCommentary: Data Now Out for Pegloticase-MTX Combo Gout Treatment – MedPage Today (free registration required)
RCT | Olokizumab, a monoclonal antibody against interleukin-6, in combination with methotrexate in patients with rheumatoid arthritis inadequately controlled by tumor necrosis factor inhibitor therapy.
19 Sep, 2022 | 12:35h | UTC
Phase 2 RCT | Combined nivolumab and ipilimumab with or without stereotactic body radiation therapy for advanced Merkel cell carcinoma.
19 Sep, 2022 | 12:32h | UTCCombined nivolumab and ipilimumab with or without stereotactic body radiation therapy for advanced Merkel cell carcinoma: a randomised, open label, phase 2 trial – The Lancet (free registration required for full-text)
RCT | Intensity-modulated radiotherapy vs. stereotactic body radiotherapy for prostate cancer.
19 Sep, 2022 | 12:31h | UTCIntensity-modulated radiotherapy versus stereotactic body radiotherapy for prostate cancer (PACE-B): 2-year toxicity results from an open-label, randomised, phase 3, non-inferiority trial – The Lancet Oncology (link to abstract – $ for full-text)
Commentary from the author on Twitter (thread – click for more)
My first Tweetorial 🧵 2 year toxicity results of PACE B published here. Big thanks to the 🇬🇧🇨🇦 and🇮🇪collaborators and the 874 men with prostate cancer who made this trial possible https://t.co/mERz2ox8TM
— Alison Tree 💙🇺🇦 (@alison_tree) September 14, 2022
RCT | Short-term outcomes of laparoscopy-assisted vs. open surgery for patients with low rectal cancer.
16 Sep, 2022 | 12:58h | UTC
Commentary on Twitter
The LASRE trial established the short-term oncologic safety of using laparoscopic surgery for low rectal cancer. The rate of complete total mesorectal excision was practically identical with laparoscopic surgery (85.3%) vs open surgery (85.8%). https://t.co/Ova2HnfO6p #Research
— JAMA Oncology (@JAMAOnc) September 15, 2022
RCT | In patients with acute pancreatitis, early aggressive hydration resulted in a higher incidence of fluid overload without improvement in clinical outcomes.
15 Sep, 2022 | 13:15h | UTCAggressive or Moderate Fluid Resuscitation in Acute Pancreatitis – New England Journal of Medicine (link to abstract – $ for full-text)