Urology
SR | Management of lymph node–positive penile cancer
24 May, 2023 | 13:03h | UTCManagement of Lymph Node–positive Penile Cancer: A Systematic Review – European Urology
Epidemiology of bladder cancer in 2023: a systematic review of risk factors
22 May, 2023 | 13:23h | UTCEpidemiology of Bladder Cancer in 2023: A Systematic Review of Risk Factors – European Urology
Fluorescence-guided surgery: comprehensive review
18 May, 2023 | 13:34h | UTCFluorescence-guided surgery: comprehensive review – BJS Open
Commentary on Twitter
Find all you ever wanted to know about the current state of fluorescence-guided surgery 🟢🔬🔪in our latest comprehensive review by @BJSurgery editor @paulo_sutt et al. Absolutely worth reading!https://t.co/Tgrj4UvOzV@BJSAcademy @juliomayol @young_bjs #SoMe4Surgery #MedTwitter pic.twitter.com/ReArdO1LOs
— BJS Open (@BjsOpen) May 17, 2023
A review of modern imaging landscape for prostate cancer: a comprehensive clinical guide
9 May, 2023 | 14:34h | UTC
21-y clinical trial update | Effects of a PSA–based screening on morbidity and mortality of prostate cancer
5 May, 2023 | 14:56h | UTC
AUA/SUO Guideline | Part I – Early detection of prostate cancer: prostate cancer screening
2 May, 2023 | 13:49h | UTC
AUA/SUO Guideline | Part II – Early detection of prostate cancer: considerations for a prostate biopsy
2 May, 2023 | 13:47h | UTC
AUA/SUO Guideline | Updates to Advanced Prostate Cancer
2 May, 2023 | 13:46h | UTCUpdates to Advanced Prostate Cancer: AUA/SUO Guideline (2023) – The Journal of Urology
AUA/SUO Guideline | Diagnosis and management of non-metastatic upper tract urothelial carcinoma
2 May, 2023 | 13:44h | UTC
AUA/SUFU Guideline | Updates to surgical treatment of female stress urinary incontinence
2 May, 2023 | 13:43h | UTC
Guideline | Urethral stricture disease
2 May, 2023 | 13:41h | UTCUrethral Stricture Disease Guideline Amendment (2023) – The Journal of Urology
Single-arm trial | Retroperitoneal lymph node dissection as first-line treatment for early metastatic seminoma shows 81% 2-Year RFS
28 Apr, 2023 | 13:02h | UTCCommentary: Retroperitoneal Lymph Node Dissection for Early Metastatic Testicular Seminoma – The ASCO Post
Review | Risk stratification of low-risk prostate cancer: individualizing care in the era of active surveillance
25 Apr, 2023 | 14:35h | UTCRisk Stratification of Low-Risk Prostate Cancer: Individualizing Care in the Era of Active Surveillance – Journal of Urology (free PDF for a limited period)
Related:
Low-Value Prostate-Specific Antigen Screening in Older Males – JAMA Network Open
RCT | Patient-reported outcomes 12 years after different treatments for localized prostate cancer
RCT | Localized prostate cancer treatment options have similar 15-year survival outcomes
Brief Review | Investigation and assessment of adrenal incidentalomas
25 Apr, 2023 | 14:13h | UTCInvestigation and assessment of adrenal incidentalomas – Clinical Medicine Journal
M-A | 5-alpha-reductase inhibitors are not associated with increased risk of mortality from prostate cancer
24 Apr, 2023 | 13:30h | UTCAssociation Between 5α-Reductase Inhibitors and Prostate Cancer Mortality: A Systematic Review and Meta-analysis – JAMA Oncology (free for a limited period)
Commentary on Twitter
Systematic review & meta-analysis drawing on 2 decades of epidemiologic literature and including data from over 3 million patients shows no significant association between use of 5-alpha reductase inhibitor use and mortality from prostate cancer. https://t.co/3l9jT1l2P9 #PCSM
— JAMA Oncology (@JAMAOnc) April 21, 2023
ASCO Guideline Update | Initial management of noncastrate advanced, recurrent, or metastatic prostate cancer
18 Apr, 2023 | 12:54h | UTC
RCT | MRI–guided vs CT–guided stereotactic body radiotherapy for prostate cancer
18 Apr, 2023 | 12:52h | UTC
RCT | Doxycycline postexposure prophylaxis effective in preventing gonorrhea, chlamydia, and syphilis in MSM
12 Apr, 2023 | 13:30h | UTCSummary: In this open-label, randomized study involving 501 men who have sex with men (MSM) and transgender women, researchers investigated the effectiveness of postexposure doxycycline in preventing bacterial sexually transmitted infections (STIs), specifically gonorrhea, chlamydia, and syphilis. Participants with a previous STI in the past year, either taking preexposure prophylaxis (PrEP) against HIV or living with HIV, were randomly assigned to receive 200 mg of doxycycline within 72 hours after condomless sex or standard care without doxycycline. STI testing was performed quarterly, with the primary end point being the incidence of at least one STI per follow-up quarter.
Results demonstrated a significant reduction in STI incidence in both the PrEP and persons living with HIV cohorts who received doxycycline. Overall, the combined incidence of these three STIs was lower by two thirds with doxycycline postexposure prophylaxis compared to standard care. The study also reported five grade 3 adverse events but no serious adverse events attributed to doxycycline. This finding supports the use of doxycycline postexposure prophylaxis among MSM with recent bacterial STIs.
Article: Postexposure Doxycycline to Prevent Bacterial Sexually Transmitted Infections – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Doxycycline after sex found to reduce STI incidence in gay men, transgender women – CIDRAP
Commentary on Twitter
In an open-label, randomized study involving men who have sex with men, doxycycline use after high-risk sexual exposure reduced the incidence of sexually transmitted infections (chlamydia, gonorrhea, and syphilis). https://t.co/tYOj8FLEy2 pic.twitter.com/bzNyvwzYS7
— NEJM (@NEJM) April 5, 2023
RCT | Effects of focal vs. extended irreversible electroporation ablation of localized prostate cancer
12 Apr, 2023 | 13:05h | UTCEffect of Focal vs Extended Irreversible Electroporation for the Ablation of Localized Low- or Intermediate-Risk Prostate Cancer on Early Oncological Control: A Randomized Clinical Trial – JAMA Surgery (link to abstract – $ for full-text)
Commentary on Twitter
Irreversible electroporation (IRE) can provide promising oncological control as a focal therapy for patients with localized low-intermediate risk prostate cancer patients. https://t.co/lmYnYpSRmY
— JAMA Surgery (@JAMASurgery) February 1, 2023
Phase 2 RCT | Addition of metastasis-directed therapy to intermittent hormone therapy for oligometastatic prostate cancer
10 Apr, 2023 | 13:41h | UTCAddition of Metastasis-Directed Therapy to Intermittent Hormone Therapy for Oligometastatic Prostate Cancer: The EXTEND Phase 2 Randomized Clinical Trial – JAMA Oncology (free for a limited period)
Commentary on Twitter
Randomized trial of intermittent hormone therapy +/- radiation to oligometastatic sites of #prostatecancer shows significantly improved PFS & assoc time off hormone therapy & w/normal testosterone from combination. https://t.co/ZnmkQuqHZm #RadOnc #PCSM #GUCSM
— JAMA Oncology (@JAMAOnc) April 6, 2023
Review | Urinary incontinence and pelvic organ prolapse in women
10 Apr, 2023 | 13:27h | UTC
ESMO Guideline | Updated treatment recommendations for prostate cancer
6 Apr, 2023 | 13:18h | UTC
Guideline | Muscle-invasive and metastatic bladder cancer
6 Apr, 2023 | 13:19h | UTCMuscle-invasive and Metastatic Bladder Cancer – European Association of Urology (see PDF)
Consensus Paper | Treatment of sexual dysfunction after surgery for prostate cancer
22 Mar, 2023 | 13:34h | UTC
RCT | Patient-reported outcomes 12 years after different treatments for localized prostate cancer
15 Mar, 2023 | 15:24h | UTCSummary: The article reports on a study that evaluated patient-reported outcomes of 1,643 participants in the ProtecT trial over a period of 7 to 12 years to assess the long-term functional and quality-of-life impacts of prostatectomy, radiotherapy with neoadjuvant androgen deprivation, and active monitoring for localized prostate cancer detected by PSA screening.
The study found that generic quality-of-life scores were similar among the randomized groups over 7 to 12 years. However, although the prostatectomy group had a lower incidence of nocturia, they showed a higher incidence of urinary incontinence and sexual dysfunction compared to the radiotherapy and active monitoring groups. The radiotherapy group had a higher incidence of fecal leakage compared to the other groups.
The study provides evidence that helps patients and their clinicians assess the trade-offs between treatment harms and benefits and make better-informed treatment decisions.
Article: Patient-Reported Outcomes 12 Years after Localized Prostate Cancer Treatment – NEJM Evidence
Original Study: RCT | Localized prostate cancer treatment options have similar 15-year survival outcomes