Hepatitis
Single-arm Phase II trial: Direct-acting antivirals as primary treatment for hepatitis C virus–associated indolent Non-Hodgkin Lymphomas.
20 Jun, 2022 | 00:51h | UTC
Case Series | Outbreak of hepatitis in children: clinical course of children with acute liver failure admitted to the intensive care unit.
13 Jun, 2022 | 10:46h | UTCOutbreak of hepatitis in children: clinical course of children with acute liver failure admitted to the intensive care unit – Intensive Care Medicine (if the link is paywalled, try this one)
Related: Investigating acute hepatitis of unknown origin in children (several resources on the subject)
Commentary on Twitter
Outbreak of non-A-E hepatitis in children, 🇬🇧 data. Good outcomes if ALF by dedicated liver #ICU with early referral to Tx centres, recognizing neuro-deterioration, high-volume #ECLS, close neuromonitoring/protection & support by hepatology/Tx physicians
📎https://t.co/GYAMaZbVGD pic.twitter.com/GA58vJWQIz— Intensive Care Medicine (@yourICM) June 10, 2022
Investigating acute hepatitis of unknown origin in children.
30 May, 2022 | 11:39h | UTCInvestigating Acute Hepatitis of Unknown Origin in Children – American Society for Microbiology
Related:
What’s sending kids to hospitals with hepatitis—coronavirus, adenovirus, or both? – Science
Puzzling pediatric hepatitis cases echo an earlier mysterious illness – STAT
Why COVID is a key suspect in severe hepatitis cases in kids worldwide – CBC
Hepatitis outbreak in children: What do we know so far? – Imperial College London
Explaining the unexplained hepatitis in children – The Lancet Infectious Diseases
Unexplained hepatitis cases in kids rise to 348 in 20 nations – CIDRAP
Multi-Country – Acute, severe hepatitis of unknown origin in children – World Health Organization
WHO says 12 countries have reported unusual cases of hepatitis in kids – STAT
Could Mysterious Hepatitis Cases be Triggered by COVID-19? – Health Policy Watch
U.S., U.K. investigating unusual cases of hepatitis in young children – STAT
Mysterious liver illness seen in kids in US, Europe – Associated Press
Commentary on Twitter
Unexplained, severe acute hepatitis has been increasingly reported in children. Adenovirus has been detected in some (but not all) cases & is being investigated as 1 of many potential causes. @andreaprinzi discusses the ongoing epidemiologic investigation: https://t.co/P6EPdT8sOA
— ASM (@ASMicrobiology) May 27, 2022
Breakthroughs in hepatitis C research: from discovery to cure.
24 May, 2022 | 07:27h | UTC
What’s sending kids to hospitals with hepatitis—coronavirus, adenovirus, or both?
23 May, 2022 | 01:48h | UTCWhat’s sending kids to hospitals with hepatitis—coronavirus, adenovirus, or both? – Science
Related:
Puzzling pediatric hepatitis cases echo an earlier mysterious illness – STAT
Why COVID is a key suspect in severe hepatitis cases in kids worldwide – CBC
Hepatitis outbreak in children: What do we know so far? – Imperial College London
Explaining the unexplained hepatitis in children – The Lancet Infectious Diseases
Unexplained hepatitis cases in kids rise to 348 in 20 nations – CIDRAP
Multi-Country – Acute, severe hepatitis of unknown origin in children – World Health Organization
WHO says 12 countries have reported unusual cases of hepatitis in kids – STAT
Could Mysterious Hepatitis Cases be Triggered by COVID-19? – Health Policy Watch
U.S., U.K. investigating unusual cases of hepatitis in young children – STAT
Mysterious liver illness seen in kids in US, Europe – Associated Press
Systematic Review: Worldwide prevalence of hepatitis B virus and hepatitis C virus among patients with cirrhosis at country, region, and global levels.
19 May, 2022 | 10:54h | UTC
Hypotheses | Severe acute hepatitis in children: investigate SARS-CoV-2 superantigens.
16 May, 2022 | 02:22h | UTCRelated:
Why COVID is a key suspect in severe hepatitis cases in kids worldwide – CBC
Hepatitis outbreak in children: What do we know so far? – Imperial College London
Explaining the unexplained hepatitis in children – The Lancet Infectious Diseases
Unexplained hepatitis cases in kids rise to 348 in 20 nations – CIDRAP
Multi-Country – Acute, severe hepatitis of unknown origin in children – World Health Organization
WHO says 12 countries have reported unusual cases of hepatitis in kids – STAT
Could Mysterious Hepatitis Cases be Triggered by COVID-19? – Health Policy Watch
U.S., U.K. investigating unusual cases of hepatitis in young children – STAT
Mysterious liver illness seen in kids in US, Europe – Associated Press
Commentary on Twitter
A solid hypothesis for the basis of the mysterious, severe acute hepatitis in children: superantigen formation from prior Covid viral reservoir in the GI tract with superimposed adenovirus infection https://t.co/1eehyQmlhi @LancetGastroHep pic.twitter.com/UqCAh3igMH
— Eric Topol (@EricTopol) May 14, 2022
Explaining the unexplained hepatitis in children.
13 May, 2022 | 11:39h | UTCExplaining the unexplained hepatitis in children – The Lancet Infectious Diseases
Related:
Unexplained hepatitis cases in kids rise to 348 in 20 nations – CIDRAP
Multi-Country – Acute, severe hepatitis of unknown origin in children – World Health Organization
WHO says 12 countries have reported unusual cases of hepatitis in kids – STAT
Could Mysterious Hepatitis Cases be Triggered by COVID-19? – Health Policy Watch
U.S., U.K. investigating unusual cases of hepatitis in young children – STAT
Mysterious liver illness seen in kids in US, Europe – Associated Press
Epidemiological update: Hepatitis of unknown etiology in children.
12 May, 2022 | 10:12h | UTCRelated:
Unexplained hepatitis cases in kids rise to 348 in 20 nations – CIDRAP
Multi-Country – Acute, severe hepatitis of unknown origin in children – World Health Organization
WHO says 12 countries have reported unusual cases of hepatitis in kids – STAT
Could Mysterious Hepatitis Cases be Triggered by COVID-19? – Health Policy Watch
U.S., U.K. investigating unusual cases of hepatitis in young children – STAT
Mysterious liver illness seen in kids in US, Europe – Associated Press
Commentary on Twitter (thread – click for more)
Update: #Hepatitis of unknown aetiology in children – 11 May 2022
Approximately 106 cases have been identified in 14 EU/EEA countries and 450 cases are reported worldwide.
The cause of the disease is still under investigation.
Read more: https://t.co/B0lLm7I0dV— ECDC Outbreaks (@ECDC_Outbreaks) May 11, 2022
Technical briefing 2: Investigation into acute hepatitis of unknown etiology in children in England.
9 May, 2022 | 02:18h | UTCRelated: With usual suspects ruled out, disease detectives try to crack mystery of viral hepatitis cases in kids (several updates on the subject)
Summary on Twitter (thread – click for more)
NEW: @UKHSA Technical Briefing 2 on Paediatric acute hepatitis in England
A 🧵 ⤵️https://t.co/E9MvVTK505 pic.twitter.com/YZCHdCdt4U
— 🇺🇦 Meaghan Kall (@kallmemeg) May 6, 2022
With usual suspects ruled out, disease detectives try to crack mystery of viral hepatitis cases in kids.
5 May, 2022 | 10:59h | UTCRelated:
Multi-Country – Acute, severe hepatitis of unknown origin in children – World Health Organization
WHO says 12 countries have reported unusual cases of hepatitis in kids – STAT
Could Mysterious Hepatitis Cases be Triggered by COVID-19? – Health Policy Watch
U.S., U.K. investigating unusual cases of hepatitis in young children – STAT
Mysterious liver illness seen in kids in US, Europe – Associated Press
CDC Report: Acute hepatitis and adenovirus infection among children.
2 May, 2022 | 00:46h | UTCCommentaries:
CDC releases new clinical details in cases of unusual hepatitis in children – CNN
CDC report finds no Covid link in children’s hepatitis cases in Alabama – NBC News
Related:
Multi-Country – Acute, severe hepatitis of unknown origin in children – World Health Organization
WHO says 12 countries have reported unusual cases of hepatitis in kids – STAT
Could Mysterious Hepatitis Cases be Triggered by COVID-19? – Health Policy Watch
U.S., U.K. investigating unusual cases of hepatitis in young children – STAT
Mysterious liver illness seen in kids in US, Europe – Associated Press
Commentaries on Twitter
Report from Alabama of acute hepatitis & adenovirus infection in young kids, Oct 21-Feb 22. 9 cases, all had adenovirus, 5/5 tested +ve for Adenovirus type 41. No epi links found. All under 6 yrs of age, immunocompetent, & no significant comorbidities. https://t.co/DcgcfN3KHo
— Andrew Lee (@andrewleedr) April 29, 2022
New report from @CDCMMWR on the 9 episodes of severe acute hepatitis in children from Alabama
All 9 positive for Adenovirus on whole blood PCR (all 5 samples sequences were type 41)
None PCR positive for #SARSCoV2
HT @tonisoriano66 https://t.co/h9LmHeVHEf
— Alasdair Munro (@apsmunro) April 29, 2022
ECDC publishes Rapid Risk Assessment – Increase in severe acute hepatitis cases of unknown etiology in children.
2 May, 2022 | 00:44h | UTCRelated:
Multi-Country – Acute, severe hepatitis of unknown origin in children – World Health Organization
WHO says 12 countries have reported unusual cases of hepatitis in kids – STAT
Could Mysterious Hepatitis Cases be Triggered by COVID-19? – Health Policy Watch
U.S., U.K. investigating unusual cases of hepatitis in young children – STAT
Mysterious liver illness seen in kids in US, Europe – Associated Press
Podcast: Curing Hepatitis C.
26 Apr, 2022 | 07:47h | UTC#329 Curing Hepatitis C – The Curbsiders
WHO: Multi-country – acute, severe hepatitis of unknown origin in children.
25 Apr, 2022 | 01:13h | UTCMulti-Country – Acute, severe hepatitis of unknown origin in children – World Health Organization
Commentaries:
WHO says 12 countries have reported unusual cases of hepatitis in kids – STAT
At least one child has died from mystery strain of severe hepatitis, WHO confirms – The Guardian
Related:
CDC Alerts Providers to Hepatitis Cases of Unknown Origin – Centers for Disease Control and Prevention AND Guidance: Recommendations for Adenovirus Testing and Reporting of Children with Acute Hepatitis of Unknown Etiology – Centers for Disease Control and Prevention
Could Mysterious Hepatitis Cases be Triggered by COVID-19? – Health Policy Watch
U.S., U.K. investigating unusual cases of hepatitis in young children – STAT
Mysterious liver illness seen in kids in US, Europe – Associated Press
CDC alerts providers to hepatitis cases of unknown origin.
22 Apr, 2022 | 09:34h | UTCCommentaries:
CDC issues health advisory about acute hepatitis in children – CNN
CDC Issues Alert for Hepatitis in Children With Adenovirus Infection – WebMD
Related:
Could Mysterious Hepatitis Cases be Triggered by COVID-19? – Health Policy Watch
U.S., U.K. investigating unusual cases of hepatitis in young children – STAT
Mysterious liver illness seen in kids in US, Europe – Associated Press
Acute hepatitis in ED setting: etiologies, evaluation, and management.
19 Apr, 2022 | 01:54h | UTCAcute Hepatitis in ED Setting: Etiologies, Evaluation, and Management – emDocs
Public health doctors and scientists are investigating 74 cases of hepatitis in children living in the UK that were not caused by hepatitis A to E virus.
18 Apr, 2022 | 10:56h | UTCCommentaries:
U.S., U.K. investigating unusual cases of hepatitis in young children – STAT
Mysterious liver illness seen in kids in US, Europe – Associated Press
Commentary on Twitter (thread – click for more)
An update on hepatitis cases in children:
We are continuing to investigate 74 cases of hepatitis (liver inflammation) in children in the UK since January 2022. 1/2
— UK Health Security Agency (@UKHSA) April 12, 2022
Nature Outlook: Hepatitis B.
31 Mar, 2022 | 08:05h | UTCHomepage: Nature Outlook: Hepatitis B
Closing in on a cure for hepatitis B
Developing a cure for chronic hepatitis B requires a fresh approach
How to stop mother-to-child transmission of hepatitis B
Simplify access to hepatitis B care
Facing the challenge of eliminating hepatitis B
The global fight against hepatitis B is benefitting some parts of the world more than others
Africa’s struggle with hepatitis B
Why hepatitis B hits Aboriginal Australians especially hard
Hepatitis B and the liver cancer endgame
Research round-up: hepatitis B
Charting a new frontier in chronic hepatitis B research to improve lives worldwide
Addressing the unmet need for a functional cure for chronic hepatitis B
M-A: Comparative efficacy and safety of pharmacological interventions to prevent Mother-to-Child transmission of hepatitis B virus.
18 Mar, 2022 | 07:37h | UTC
Single-center RCT: Accessible Hepatitis C care for people who inject drugs.
15 Mar, 2022 | 08:36h | UTCAccessible Hepatitis C Care for People Who Inject Drugs: A Randomized Clinical Trial – JAMA Internal Medicine (free for a limited period)
Commentary on Twitter
This randomized clinical trial found that the accessible care model provides a framework for developing treatment programs geared toward engaging, treating, and curing hepatitis C virus infection in people who inject drugs. https://t.co/zauS1gtPgO
— JAMA Internal Medicine (@JAMAInternalMed) March 14, 2022
Cohort Study: Among patients with resolved Hepatitis B infections and concomitant autoimmune disease, exposure to prednisone doses greater than 20 mg/day were associated with a high risk for HBV reactivation or hepatitis flare.
21 Jan, 2022 | 09:39h | UTCAverage corticosteroid dose and risk for HBV reactivation and hepatitis flare in patients with resolved hepatitis B infection – Annals of Rheumatic Disease (link to abstract – $ for full-text)
Commentary on Twitter
Patients with time-weighted average prednisone dose greater than 20 mg/day would be classified as the high risk for HBV reactivation or hepatitis flare. Prophylactic Anti-HBV therapy may be needed for these high-risk patientshttps://t.co/qLuirdyXDK pic.twitter.com/yDJ4c072qm
— ARD & RMD Open (@ARD_BMJ) December 23, 2021
WHO Urges Countries to Increase Hepatitis Services.
3 Aug, 2021 | 02:26h | UTCWHO Urges Countries to Increase Hepatitis Services – Health Policy Watch
WHO Campaign: World Hepatitis Day (28 July)
New WHO guidelines:
Recommendations and guidance on hepatitis C virus self-testing – World Health Organization
Interim guidance for country validation of viral hepatitis elimination – World Health Organization
WHO releases first-ever global guidance for country validation of viral hepatitis B and C elimination.
15 Jul, 2021 | 09:16h | UTCSee guidance: Interim guidance for country validation of viral hepatitis elimination – World Health Organization
New WHO report highlights global progress on reducing HIV, viral hepatitis and sexually transmitted infections and signals need for renewed efforts to reach 2030 targets.
21 May, 2021 | 08:33h | UTCOriginal report: Global progress report on HIV, viral hepatitis and sexually transmitted infections, 2021 – World Health Organization
Commentary on Twitter (thread – click for more)
Every year HIV, viral hepatitis, and sexually transmitted infections account for 2.3M deaths, and 1.2M cancers
🆕WHO report highlights achievements, gaps, and actions towards eliminating these diseases as public health threats by 2030 👉https://t.co/8kcVqZe0Yj pic.twitter.com/U07hKRumVt
— World Health Organization (WHO) (@WHO) May 20, 2021