Hepatitis
KDIGO 2022 Guideline for the prevention, diagnosis, evaluation, and treatment of Hepatitis C in chronic kidney disease.
23 Nov, 2022 | 14:11h | UTCExecutive Summary: KDIGO 2022 Clinical Practice Guideline for the Prevention, Diagnosis, Evaluation, and Treatment of Hepatitis C in Chronic Kidney Disease – Kidney International
Phase 2b RCT | Efficacy and safety of Bepirovirsen in chronic Hepatitis B infection.
11 Nov, 2022 | 13:44h | UTCEfficacy and Safety of Bepirovirsen in Chronic Hepatitis B Infection – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary on Twitter
In a phase 2 trial, bepirovirsen, an antisense oligonucleotide that targets all hep B virus (HBV) messenger RNAs, resulted in sustained loss of hep B surface antigen and HBV DNA in 9 to 10% of participants with chronic HBV infection. #TLM22 #LiverTwitter https://t.co/krJcMEDhIX pic.twitter.com/SistuAocZO
— NEJM (@NEJM) November 8, 2022
Choosing Wisely | Top five list of procedures to avoid in the treatment of viral hepatitis.
7 Oct, 2022 | 14:22h | UTCSee complete lists of low-value practices: Choosing Wisely U.S. / Choosing Wisely UK / Choosing Wisely Australia AND Choosing Wisely Canada
M-A | Risk of hepatitis C virus infection associated with hospital-based invasive procedures.
29 Aug, 2022 | 12:00h | UTC
M-A | Prevalence of occult hepatitis B virus infection in adults.
15 Aug, 2022 | 11:59h | UTC
Commentary on Twitter
New Article online — a systematic review and meta-analysis of the prevalence of occult #HBV infection in adults — FREE to read https://t.co/oaa1HHfQo0@dryuriim @leithdamien @chipsliverlover @GeYueqi @gndow @maud_lemoine #LiverTwitter #IDtwitter #viralhepatitis #hepatitisB pic.twitter.com/liMf9CBAzK
— The Lancet Gastroenterology & Hepatology (@LancetGastroHep) August 10, 2022
WHO Guidelines on HIV, viral hepatitis and STI prevention, diagnosis, treatment and care for key populations.
2 Aug, 2022 | 12:41h | UTCNews Release: WHO publishes new guidelines on HIV, hepatitis and STIs for key populations – World Health Organization
Severe acute hepatitis of unknown etiology in children—what is known?
2 Aug, 2022 | 12:39h | UTCSevere acute hepatitis of unknown aetiology in children—what is known? – BMC Medicine
Related:
A Case Series of Children with Acute Hepatitis and Human Adenovirus Infection – New England Journal of Medicine (link to abstract – $ for full-text)
Clinical Spectrum of Children with Acute Hepatitis of Unknown Cause – New England Journal of Medicine (link to abstract – $ for full-text)
Severe acute hepatitis of unknown aetiology in children – Multi-country – World Health Organization
Sudden onset hepatitis in children – Nature Reviews Gastroenterology & Hepatology (if the link is paywalled, try this one)
Outbreak of hepatitis in children: clinical course of children with acute liver failure admitted to the intensive care unit – Intensive Care Medicine (if the link is paywalled, try this one)
Investigating Acute Hepatitis of Unknown Origin in Children – American Society for Microbiology
What’s sending kids to hospitals with hepatitis—coronavirus, adenovirus, or both? – Science
Puzzling pediatric hepatitis cases echo an earlier mysterious illness – STAT
Why COVID is a key suspect in severe hepatitis cases in kids worldwide – CBC
Hepatitis outbreak in children: What do we know so far? – Imperial College London
Explaining the unexplained hepatitis in children – The Lancet Infectious Diseases
Unexplained hepatitis cases in kids rise to 348 in 20 nations – CIDRAP
Multi-Country – Acute, severe hepatitis of unknown origin in children – World Health Organization
WHO says 12 countries have reported unusual cases of hepatitis in kids – STAT
Could Mysterious Hepatitis Cases be Triggered by COVID-19? – Health Policy Watch
U.S., U.K. investigating unusual cases of hepatitis in young children – STAT
Mysterious liver illness seen in kids in US, Europe – Associated Press
Cohort Study | Taiwan’s nationwide Hepatitis B vaccination and antiviral therapy program reduced end-stage liver disease burden.
25 Jul, 2022 | 12:54h | UTC
Commentary on Twitter
This cohort study found the nationwide implementation of hepatitis B vaccination (1984) and antiviral treatment programs (2003) was followed by dramatic reductions in the burden of end-stage liver disease in Taiwan. https://t.co/Qnei2abi85
— JAMA Network Open (@JAMANetworkOpen) July 18, 2022
WHO Updated Report | Severe acute hepatitis of unknown etiology in children.
14 Jul, 2022 | 12:54h | UTCSevere acute hepatitis of unknown aetiology in children – Multi-country – World Health Organization
Related:
Sudden onset hepatitis in children – Nature Reviews Gastroenterology & Hepatology (if the link is paywalled, try this one)
Outbreak of hepatitis in children: clinical course of children with acute liver failure admitted to the intensive care unit – Intensive Care Medicine (if the link is paywalled, try this one)
Investigating Acute Hepatitis of Unknown Origin in Children – American Society for Microbiology
What’s sending kids to hospitals with hepatitis—coronavirus, adenovirus, or both? – Science
Puzzling pediatric hepatitis cases echo an earlier mysterious illness – STAT
Why COVID is a key suspect in severe hepatitis cases in kids worldwide – CBC
Hepatitis outbreak in children: What do we know so far? – Imperial College London
Explaining the unexplained hepatitis in children – The Lancet Infectious Diseases
Unexplained hepatitis cases in kids rise to 348 in 20 nations – CIDRAP
Multi-Country – Acute, severe hepatitis of unknown origin in children – World Health Organization
WHO says 12 countries have reported unusual cases of hepatitis in kids – STAT
Could Mysterious Hepatitis Cases be Triggered by COVID-19? – Health Policy Watch
U.S., U.K. investigating unusual cases of hepatitis in young children – STAT
Mysterious liver illness seen in kids in US, Europe – Associated Press
A case series of children with acute hepatitis and human Adenovirus infection.
14 Jul, 2022 | 12:56h | UTCA Case Series of Children with Acute Hepatitis and Human Adenovirus Infection – New England Journal of Medicine (link to abstract – $ for full-text)
Related Study: Clinical Spectrum of Children with Acute Hepatitis of Unknown Cause – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Unexplained Acute Hepatitis in Children: More Evidence for Adenovirus 41 — Two studies point to a suspiciously high prevalence – MedPage Today (free registration required)
Commentaries on Twitter
A majority of children admitted to a single hospital in late 2021–early 2022 with acute hepatitis of unknown cause tested positive for adenovirus. This report describes the children’s illnesses and outcomes. https://t.co/QYvi6U1jUN pic.twitter.com/auPRq1duQm
— NEJM (@NEJM) July 13, 2022
From January–April 2022, 44 children with acute hepatitis of unknown cause were referred to a liver-transplantation center in the U.K. Six underwent liver transplantation. https://t.co/CMI4KCqdxM pic.twitter.com/og72u58L5R
— NEJM (@NEJM) July 13, 2022
Indeterminate pediatric acute liver failure: clinical characteristics of a temporal cluster of five children in the Netherlands in the spring of 2022.
5 Jul, 2022 | 12:09h | UTCRelated:
Sudden onset hepatitis in children – Nature Reviews Gastroenterology & Hepatology (if the link is paywalled, try this one)
Severe acute hepatitis of unknown aetiology in children – Multi-country – World Health Organization
Outbreak of hepatitis in children: clinical course of children with acute liver failure admitted to the intensive care unit – Intensive Care Medicine (if the link is paywalled, try this one)
Investigating Acute Hepatitis of Unknown Origin in Children – American Society for Microbiology
What’s sending kids to hospitals with hepatitis—coronavirus, adenovirus, or both? – Science
Puzzling pediatric hepatitis cases echo an earlier mysterious illness – STAT
Why COVID is a key suspect in severe hepatitis cases in kids worldwide – CBC
Hepatitis outbreak in children: What do we know so far? – Imperial College London
Explaining the unexplained hepatitis in children – The Lancet Infectious Diseases
Unexplained hepatitis cases in kids rise to 348 in 20 nations – CIDRAP
Multi-Country – Acute, severe hepatitis of unknown origin in children – World Health Organization
WHO says 12 countries have reported unusual cases of hepatitis in kids – STAT
Could Mysterious Hepatitis Cases be Triggered by COVID-19? – Health Policy Watch
U.S., U.K. investigating unusual cases of hepatitis in young children – STAT
Mysterious liver illness seen in kids in US, Europe – Associated Press
Brief Review | Sudden onset hepatitis in children.
4 Jul, 2022 | 12:41h | UTCSudden onset hepatitis in children – Nature Reviews Gastroenterology & Hepatology (if the link is paywalled, try this one)
Related: WHO Updated Report: Severe acute hepatitis of unknown etiology in children. (several articles on the subject)
Commentary on Twitter
NEW! In this COMMENT by @ZaniaStamataki & @kellyda60 summarise what we know so far about sudden onset #hepatitis of unexplained origin in childrenhttps://t.co/AYTR8wrG3C
Read-only link https://t.co/dgyzRhpODT#paediatrics pic.twitter.com/1WLQfaRrdx
— Nature Reviews Gastroenterology & Hepatology (@NatRevGastroHep) July 1, 2022
WHO Updated Report: Severe acute hepatitis of unknown etiology in children.
28 Jun, 2022 | 11:23h | UTCSevere acute hepatitis of unknown aetiology in children – Multi-country – World Health Organization
Related:
Outbreak of hepatitis in children: clinical course of children with acute liver failure admitted to the intensive care unit – Intensive Care Medicine (if the link is paywalled, try this one)
Investigating Acute Hepatitis of Unknown Origin in Children – American Society for Microbiology
What’s sending kids to hospitals with hepatitis—coronavirus, adenovirus, or both? – Science
Puzzling pediatric hepatitis cases echo an earlier mysterious illness – STAT
Why COVID is a key suspect in severe hepatitis cases in kids worldwide – CBC
Hepatitis outbreak in children: What do we know so far? – Imperial College London
Explaining the unexplained hepatitis in children – The Lancet Infectious Diseases
Unexplained hepatitis cases in kids rise to 348 in 20 nations – CIDRAP
Multi-Country – Acute, severe hepatitis of unknown origin in children – World Health Organization
WHO says 12 countries have reported unusual cases of hepatitis in kids – STAT
Could Mysterious Hepatitis Cases be Triggered by COVID-19? – Health Policy Watch
U.S., U.K. investigating unusual cases of hepatitis in young children – STAT
Mysterious liver illness seen in kids in US, Europe – Associated Press
Global, regional, and national burden of hepatitis B, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019.
27 Jun, 2022 | 11:17h | UTCCommentary: Chronic Hepatitis B Infections Decreasing in Recent Years – HCP Live
Commentary on Twitter
New research from #GBDStudy – Global, regional, and national burden of hepatitis B, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019https://t.co/e0oxlT2gKd#hepB #HBV #nohep #livertwitter @IHME_UW pic.twitter.com/V8h1LrCoUQ
— The Lancet Gastroenterology & Hepatology (@LancetGastroHep) June 21, 2022
Single-arm Phase II trial: Direct-acting antivirals as primary treatment for hepatitis C virus–associated indolent Non-Hodgkin Lymphomas.
20 Jun, 2022 | 00:51h | UTC
Case Series | Outbreak of hepatitis in children: clinical course of children with acute liver failure admitted to the intensive care unit.
13 Jun, 2022 | 10:46h | UTCOutbreak of hepatitis in children: clinical course of children with acute liver failure admitted to the intensive care unit – Intensive Care Medicine (if the link is paywalled, try this one)
Related: Investigating acute hepatitis of unknown origin in children (several resources on the subject)
Commentary on Twitter
Outbreak of non-A-E hepatitis in children, 🇬🇧 data. Good outcomes if ALF by dedicated liver #ICU with early referral to Tx centres, recognizing neuro-deterioration, high-volume #ECLS, close neuromonitoring/protection & support by hepatology/Tx physicians
📎https://t.co/GYAMaZbVGD pic.twitter.com/GA58vJWQIz— Intensive Care Medicine (@yourICM) June 10, 2022
Investigating acute hepatitis of unknown origin in children.
30 May, 2022 | 11:39h | UTCInvestigating Acute Hepatitis of Unknown Origin in Children – American Society for Microbiology
Related:
What’s sending kids to hospitals with hepatitis—coronavirus, adenovirus, or both? – Science
Puzzling pediatric hepatitis cases echo an earlier mysterious illness – STAT
Why COVID is a key suspect in severe hepatitis cases in kids worldwide – CBC
Hepatitis outbreak in children: What do we know so far? – Imperial College London
Explaining the unexplained hepatitis in children – The Lancet Infectious Diseases
Unexplained hepatitis cases in kids rise to 348 in 20 nations – CIDRAP
Multi-Country – Acute, severe hepatitis of unknown origin in children – World Health Organization
WHO says 12 countries have reported unusual cases of hepatitis in kids – STAT
Could Mysterious Hepatitis Cases be Triggered by COVID-19? – Health Policy Watch
U.S., U.K. investigating unusual cases of hepatitis in young children – STAT
Mysterious liver illness seen in kids in US, Europe – Associated Press
Commentary on Twitter
Unexplained, severe acute hepatitis has been increasingly reported in children. Adenovirus has been detected in some (but not all) cases & is being investigated as 1 of many potential causes. @andreaprinzi discusses the ongoing epidemiologic investigation: https://t.co/P6EPdT8sOA
— ASM (@ASMicrobiology) May 27, 2022
Breakthroughs in hepatitis C research: from discovery to cure.
24 May, 2022 | 07:27h | UTC
What’s sending kids to hospitals with hepatitis—coronavirus, adenovirus, or both?
23 May, 2022 | 01:48h | UTCWhat’s sending kids to hospitals with hepatitis—coronavirus, adenovirus, or both? – Science
Related:
Puzzling pediatric hepatitis cases echo an earlier mysterious illness – STAT
Why COVID is a key suspect in severe hepatitis cases in kids worldwide – CBC
Hepatitis outbreak in children: What do we know so far? – Imperial College London
Explaining the unexplained hepatitis in children – The Lancet Infectious Diseases
Unexplained hepatitis cases in kids rise to 348 in 20 nations – CIDRAP
Multi-Country – Acute, severe hepatitis of unknown origin in children – World Health Organization
WHO says 12 countries have reported unusual cases of hepatitis in kids – STAT
Could Mysterious Hepatitis Cases be Triggered by COVID-19? – Health Policy Watch
U.S., U.K. investigating unusual cases of hepatitis in young children – STAT
Mysterious liver illness seen in kids in US, Europe – Associated Press
Systematic Review: Worldwide prevalence of hepatitis B virus and hepatitis C virus among patients with cirrhosis at country, region, and global levels.
19 May, 2022 | 10:54h | UTC
Hypotheses | Severe acute hepatitis in children: investigate SARS-CoV-2 superantigens.
16 May, 2022 | 02:22h | UTCRelated:
Why COVID is a key suspect in severe hepatitis cases in kids worldwide – CBC
Hepatitis outbreak in children: What do we know so far? – Imperial College London
Explaining the unexplained hepatitis in children – The Lancet Infectious Diseases
Unexplained hepatitis cases in kids rise to 348 in 20 nations – CIDRAP
Multi-Country – Acute, severe hepatitis of unknown origin in children – World Health Organization
WHO says 12 countries have reported unusual cases of hepatitis in kids – STAT
Could Mysterious Hepatitis Cases be Triggered by COVID-19? – Health Policy Watch
U.S., U.K. investigating unusual cases of hepatitis in young children – STAT
Mysterious liver illness seen in kids in US, Europe – Associated Press
Commentary on Twitter
A solid hypothesis for the basis of the mysterious, severe acute hepatitis in children: superantigen formation from prior Covid viral reservoir in the GI tract with superimposed adenovirus infection https://t.co/1eehyQmlhi @LancetGastroHep pic.twitter.com/UqCAh3igMH
— Eric Topol (@EricTopol) May 14, 2022
Explaining the unexplained hepatitis in children.
13 May, 2022 | 11:39h | UTCExplaining the unexplained hepatitis in children – The Lancet Infectious Diseases
Related:
Unexplained hepatitis cases in kids rise to 348 in 20 nations – CIDRAP
Multi-Country – Acute, severe hepatitis of unknown origin in children – World Health Organization
WHO says 12 countries have reported unusual cases of hepatitis in kids – STAT
Could Mysterious Hepatitis Cases be Triggered by COVID-19? – Health Policy Watch
U.S., U.K. investigating unusual cases of hepatitis in young children – STAT
Mysterious liver illness seen in kids in US, Europe – Associated Press
Epidemiological update: Hepatitis of unknown etiology in children.
12 May, 2022 | 10:12h | UTCRelated:
Unexplained hepatitis cases in kids rise to 348 in 20 nations – CIDRAP
Multi-Country – Acute, severe hepatitis of unknown origin in children – World Health Organization
WHO says 12 countries have reported unusual cases of hepatitis in kids – STAT
Could Mysterious Hepatitis Cases be Triggered by COVID-19? – Health Policy Watch
U.S., U.K. investigating unusual cases of hepatitis in young children – STAT
Mysterious liver illness seen in kids in US, Europe – Associated Press
Commentary on Twitter (thread – click for more)
Update: #Hepatitis of unknown aetiology in children – 11 May 2022
Approximately 106 cases have been identified in 14 EU/EEA countries and 450 cases are reported worldwide.
The cause of the disease is still under investigation.
Read more: https://t.co/B0lLm7I0dV— ECDC Outbreaks (@ECDC_Outbreaks) May 11, 2022
Technical briefing 2: Investigation into acute hepatitis of unknown etiology in children in England.
9 May, 2022 | 02:18h | UTCRelated: With usual suspects ruled out, disease detectives try to crack mystery of viral hepatitis cases in kids (several updates on the subject)
Summary on Twitter (thread – click for more)
NEW: @UKHSA Technical Briefing 2 on Paediatric acute hepatitis in England
A 🧵 ⤵️https://t.co/E9MvVTK505 pic.twitter.com/YZCHdCdt4U
— 🇺🇦 Meaghan Kall (@kallmemeg) May 6, 2022
With usual suspects ruled out, disease detectives try to crack mystery of viral hepatitis cases in kids.
5 May, 2022 | 10:59h | UTCRelated:
Multi-Country – Acute, severe hepatitis of unknown origin in children – World Health Organization
WHO says 12 countries have reported unusual cases of hepatitis in kids – STAT
Could Mysterious Hepatitis Cases be Triggered by COVID-19? – Health Policy Watch
U.S., U.K. investigating unusual cases of hepatitis in young children – STAT
Mysterious liver illness seen in kids in US, Europe – Associated Press