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Maternal-Fetal Medicine

RCT: Prophylactic closed incision negative pressure wound therapy reduces (difference close to statistical significance; P=0.06) the risk of surgical site infection in obese women undergoing cesarean section.

7 May, 2021 | 08:24h | UTC

Closed incision negative pressure wound therapy versus standard dressings in obese women undergoing caesarean section: multicentre parallel group randomised controlled trial – The BMJ

 


WHO: New report sounds the alarm on global shortage of 900 000 midwives.

6 May, 2021 | 08:45h | UTC

New report sounds the alarm on global shortage of 900 000 midwives – World Health Organization

Report: The State of the World’s Midwifery 2021 – UN sexual and reproductive health agency

 

Commentary on Twitter (thread – click for more)

 


Cohort study: Risk of developmental difficulties remains high among children born early

5 May, 2021 | 08:24h | UTC

Neurodevelopmental outcomes at age 5 among children born preterm: EPIPAGE-2 cohort study – The BMJ

News release: Risk of developmental difficulties remains high among children born early – The BMJ

 

Commentary on Twitter

 


RCT: Community-initiated kangaroo mother care reduced the risk of moderate-to-severe maternal postpartum depressive symptoms among mothers of low-birth-weight infants in low-income areas in India

5 May, 2021 | 08:21h | UTC

Effect of Community-Initiated Kangaroo Mother Care on Postpartum Depressive Symptoms and Stress Among Mothers of Low-Birth-Weight Infants: A Randomized Clinical Trial – JAMA Network Open

 

Commentary on Twitter

 


The Lancet Series | Miscarriage matters

3 May, 2021 | 05:11h | UTC

Editorial: Miscarriage: worldwide reform of care is needed

 


RCT: Tranexamic acid for the prevention of blood loss after cesarean delivery – even though TA resulted in a significantly lower incidence of estimated blood loss, the clinical relevance of the findings was small

30 Apr, 2021 | 08:38h | UTC

Tranexamic Acid for the Prevention of Blood Loss after Cesarean Delivery – New England Journal of Medicine

 

Commentaries on Twitter

 


Cohort study: Association of maternal SARS-CoV-2 infection in pregnancy with neonatal outcomes – “although babies born of test-positive mothers are more likely to be born early, extremely few were infected with COVID-19”

30 Apr, 2021 | 08:17h | UTC

Association of Maternal SARS-CoV-2 Infection in Pregnancy With Neonatal Outcomes – JAMA

News release: Low risk of infection in babies born to mothers with COVID-19 – Karolinska Institutet

Editorial: Understanding Risk for Newborns Born to SARS-CoV-2–Positive Mothers – JAMA

 

Commentary on Twitter

 


Pre-post study: A hospital quality improvement intervention significantly reduced the rates of cesarean delivery for nulliparous, term, singleton, vertex births

29 Apr, 2021 | 08:21h | UTC

Hospital Quality Improvement Interventions, Statewide Policy Initiatives, and Rates of Cesarean Delivery for Nulliparous, Term, Singleton, Vertex Births in California – JAMA (free for a limited period)

Editorial: Initiatives to Reduce Cesarean Delivery Rates for Low-risk First Births – JAMA

 

Commentary on Twitter (thread – click for more)

 


M-A: Effectiveness of intrapartum fetal surveillance to improve maternal and neonatal outcomes – “none of the newer surveillance methods seem to significantly reduce emergency cesarean deliveries in labor or neonatal morbidity compared with using simple intermittent auscultation of the fetal heart”

28 Apr, 2021 | 08:08h | UTC

Effectiveness of intrapartum fetal surveillance to improve maternal and neonatal outcomes: a systematic review and network meta-analysis – Canadian Medical Association Journal

 


RCT: Metformin vs. insulin in gestational diabetes – metformin was associated better glycemic control, lower risk of hypoglycemia, and less maternal weight gain

25 Apr, 2021 | 21:03h | UTC

MeDiGes Study. Metformin versus insulin in gestational diabetes: Glycemic control, and obstetrical and perinatal outcomes. Randomized prospective trial. – American Journal of Obstetrics & Gynecology (link to abstract – $ for full-text)

Related: Randomized trial tests metformin in women with type 2 diabetes in pregnancy AND Neonatal, infant, and childhood growth following metformin versus insulin treatment for gestational diabetes: A systematic review and meta-analysis – PLOS Medicine AND Case-Control Study: Metformin Exposure in First Trimester of Pregnancy is Not Associated with Congenital Anomalies

 


RCT: Induction of Labor at Term with Vaginal Misoprostol or a PGE2 Pessary – little difference in outcomes, the clinical risk-benefit ratio justifies the use of both drugs

25 Apr, 2021 | 20:59h | UTC

Induction of Labor at Term With Vaginal Misoprostol or a PGE2 Pessary: a Noninferiority RCT – American Journal of Obstetrics & Gynecology (link to abstract – $ for full-text)

 


Recommendations on the Management of Maternal Hepatitis B, C and D Infection in Pregnancy

25 Apr, 2021 | 20:44h | UTC

Recommendations of the AGG (Task Force for Obstetrics, Section Maternal Diseases) on the Management of Maternal Hepatitis B, C and D Infection in Pregnancy – Geburtshilfe und Frauenheilkunde

 


Covid-19: More data on the increased risks to pregnant women and their newborn infants

23 Apr, 2021 | 08:44h | UTC

Maternal and Neonatal Morbidity and Mortality Among Pregnant Women With and Without COVID-19 Infection: The INTERCOVID Multinational Cohort Study – JAMA Pediatrics

Editorial: COVID-19 in Pregnant Women and Their Newborn Infants

Commentaries: Pregnant women with COVID-19 face high mortality rate – University of Washington School of Medicine AND Covid-19 raises risks for expectant mothers and babies, study says – CNN

Related: Effects of the COVID-19 pandemic on maternal and perinatal outcomes: a systematic review and meta-analysis

 

Commentary on Twitter

 


Preliminary Findings of mRNA Covid-19 Vaccine Safety in Pregnant Persons

22 Apr, 2021 | 08:49h | UTC

Preliminary Findings of mRNA Covid-19 Vaccine Safety in Pregnant Persons – New England Journal of Medicine

Audio Interview: Covid-19 Vaccines and Pregnancy — A Conversation with CDC Director Rochelle Walensky – New England Journal of Medicine

Commentaries: No evidence that Pfizer or Moderna vaccines are unsafe during pregnancy, a preliminary study says. – The New York Times AND Preliminary data show no safety concerns for pregnant women receiving COVID-19 vaccines – AAP News AND Messenger RNA COVID vaccines likely safe for pregnant women: Study – ABC News

 


Maternal, Fetal, and Child Outcomes of Mental Health Treatments in Women: A Systematic Review of Perinatal Pharmacologic Interventions

22 Apr, 2021 | 08:19h | UTC

Maternal, Fetal, and Child Outcomes of Mental Health Treatments in Women: A Systematic Review of Perinatal Pharmacologic Interventions – Agency for Healthcare Research and Quality

See also: Final Report AND Evidence Summary

 


M-A: Progestogens for preventing miscarriage

21 Apr, 2021 | 06:22h | UTC

Progestogens for preventing miscarriage: a network meta‐analysis – Cochrane Library

Summary: Are progestogen treatments effective in preventing miscarriage? – Cochrane Library

Related Meta-analysis: Evaluating Progestogens for Preventing Preterm birth International Collaborative (EPPPIC): meta-analysis of individual participant data from randomised controlled trials – The Lancet (link to abstract – $ for full-text)

 


RCT: Continued versus discontinued oxytocin stimulation in the active phase of labor

16 Apr, 2021 | 06:18h | UTC

Continued versus discontinued oxytocin stimulation in the active phase of labour (CONDISOX): double blind randomised controlled trial – The BMJ

Commentaries: Study sheds more light on use of oxytocin during labour – The BMJ AND Study Explores Oxytocin Use in Active Phase of Induced Labor – HealthDay

 

Commentary on Twitter

 


Were pregnant women more affected by COVID-19 in the second wave of the pandemic?

16 Apr, 2021 | 06:24h | UTC

Were pregnant women more affected by COVID-19 in the second wave of the pandemic? – The Lancet

Related: Effects of the COVID-19 pandemic on maternal and perinatal outcomes: a systematic review and meta-analysis

 


M-A: Antenatal corticosteroids for impending late preterm (34-36+6 weeks) deliveries

7 Apr, 2021 | 01:22h | UTC

Antenatal corticosteroids for impending late preterm (34-36+6 weeks) deliveries—A systematic review and meta-analysis of RCTs – PLOS One

 


Randomized controlled trial compared three antiretroviral regimens started in pregnant women with HIV

2 Apr, 2021 | 09:15h | UTC

Efficacy and safety of dolutegravir with emtricitabine and tenofovir alafenamide fumarate or tenofovir disoproxil fumarate, and efavirenz, emtricitabine, and tenofovir disoproxil fumarate HIV antiretroviral therapy regimens started in pregnancy (IMPAACT 2010/VESTED): a multicentre, open-label, randomised, controlled, phase 3 trial – The Lancet (link to abstract – $ for full-text)

Commentary: ART in pregnant women living with HIV – The Lancet

 


Guideline for elective cesarean section: updated systematic review and procedure‐specific postoperative pain management recommendations

2 Apr, 2021 | 09:09h | UTC

PROSPECT guideline for elective caesarean section: updated systematic review and procedure‐specific postoperative pain management recommendations – Anaesthesia

 


Effects of the COVID-19 pandemic on maternal and perinatal outcomes: a systematic review and meta-analysis

2 Apr, 2021 | 09:23h | UTC

Effects of the COVID-19 pandemic on maternal and perinatal outcomes: a systematic review and meta-analysis – The Lancet Global Health

Commentaries: Covid-19 led to a global increase in stillbirths, maternal mortality, and depression, review finds – CNN AND COVID-19 pandemic and health-care disruptions: count the most vulnerable – The Lancet Global Health

 

Commentary on Twitter

 


Obesity in women: anesthetic implications for peri‐operative and peripartum management

2 Apr, 2021 | 09:07h | UTC

Obesity in women: anaesthetic implications for peri‐operative and peripartum management – Anaesthesia

 


Cohort study: Association of spontaneous abortion with all cause and cause specific premature mortality

1 Apr, 2021 | 03:27h | UTC

Association of spontaneous abortion with all cause and cause specific premature mortality: prospective cohort study – The BMJ

Commentaries: Miscarriage linked to increased risk of early death – The BMJ AND Miscarriage Linked to Higher Risk for Premature Mortality – HealthDay

 

Commentary on Twitter

 


RCT: Six vs. Twelve Hours of Single Balloon Catheter Placement with Oxytocin Administration for Labor Induction

31 Mar, 2021 | 03:02h | UTC

Six vs. Twelve Hours of Single Balloon Catheter Placement with Oxytocin Administration for Labor Induction: A Randomized Controlled Trial – American Journal of Obstetrics & Gynecology (link to abstract – $ for full-text)

 


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