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GI Surgery – Stomach and Duodenum

RCT | Hemostatic powder provides better control of gastrointestinal tumor bleeding than standard endoscopic treatment

20 Jun, 2023 | 12:39h | UTC

Hemostatic powder vs. standard endoscopic treatment for gastrointestinal tumor bleeding: A multicenter randomized trial – Gastroenterology (link to abstract – $ for full-text)

 


Review | Hereditary colorectal, gastric, and pancreatic cancer

18 May, 2023 | 13:43h | UTC

Hereditary colorectal, gastric, and pancreatic cancer: comprehensive review – BJS Open

 

Commentary on Twitter

 


Review | Helicobacter pylori infection

2 May, 2023 | 13:37h | UTC

Helicobacter pylori infection – Nature Reviews Disease Primers (if the link is paywalled, try this one)

 

Commentary on Twitter

 


Cohort Study | Cancer surveillance as an alternative to prophylactic total gastrectomy in hereditary diffuse gastric cancer

17 Apr, 2023 | 12:57h | UTC

Cancer surveillance as an alternative to prophylactic total gastrectomy in hereditary diffuse gastric cancer: a prospective cohort study – The Lancet Oncology (link to abstract – $ for full-text)

Commentary: Endoscopic Surveillance in Patients at Risk for Hereditary Diffuse Gastric Cancer – The ASCO Post

 


RCT | Over-the-scope clips show lower rebleeding rates in nonvariceal GI bleeding

6 Apr, 2023 | 12:57h | UTC

Comparison of Over-the-Scope Clips to Standard Endoscopic Treatment as the Initial Treatment in Patients With Bleeding From a Nonvariceal Upper Gastrointestinal Cause: A Randomized Controlled Trial – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries:

Over-the-Scope Clip Beneficial for Nonvariceal Upper GI Bleeding – HealthDay

Over-the-scope clips superior to standard treatment of nonvariceal upper GI bleeding – Physician’s Weekly

 

Commentary on Twitter

 


Brief Review | What every gastroenterologist should know about gastrointestinal neuroendocrine tumors

4 Apr, 2023 | 13:29h | UTC

What Every Gastroenterologist Should Know About Gastrointestinal NETs – American Journal of Gastroenterology

 


Gastric Cancer: the combined impact of H. pylori infection and pathogenic gene variants

3 Apr, 2023 | 13:51h | UTC

Helicobacter pylori, Homologous-Recombination Genes, and Gastric Cancer – New England Journal of Medicine (link to abstract – $ for full-text)

News Release: Helicobacter Pylori Infection Modifies the Risk of Gastric Cancer Associated with Germline Pathogenic Variants in Homologous Recombination Genes – ESMO

Commentary: H. Pylori Infection Negatively Modifies Genetically Increased Risk for Gastric Cancer – Physician’s Weekly

 

Commentary on Twitter

 


Guidelines for Gastric Cancer | An evidence-based, multidisciplinary approach

22 Mar, 2023 | 13:33h | UTC

Korean Practice Guidelines for Gastric Cancer 2022: An Evidence-based, Multidisciplinary Approach – Journal of Gastric Cancer

 


RCT | Comparable 5-year relapse-free survival for laparoscopic vs. open distal gastrectomy in advanced gastric cancer

22 Mar, 2023 | 13:27h | UTC

Summary: The JLSSG0901 randomized clinical trial aimed to compare the 5-year survival outcomes of laparoscopy-assisted distal gastrectomy (LADG) and open distal gastrectomy (ODG) with D2 lymph node dissection for locally advanced gastric cancer.

The study involved 507 patients from 37 institutes in Japan. The primary endpoint was 5-year relapse-free survival. The results showed that the 5-year relapse-free survival rates were 73.9% and 75.7% for the ODG and LADG groups, respectively, confirming the noninferiority of LADG, and no significant differences were observed in severe postoperative complications between the two groups.

The study concluded that LADG with D2 lymph node dissection, when performed by qualified surgeons, was proven noninferior to ODG, and could become a standard treatment for locally advanced gastric cancer.

Article: Five-Year Survival Outcomes of Laparoscopy-Assisted vs Open Distal Gastrectomy for Advanced Gastric Cancer: The JLSSG0901 Randomized Clinical Trial – JAMA Surgery (link to abstract – $ for full-text)

Related:

Laparoscopic vs. open distal gastrectomy for locally advanced gastric cancer: A systematic review and meta-analysis of randomized controlled trials – Frontiers in Surgery

Laparoscopic vs Open Distal Gastrectomy for Locally Advanced Gastric Cancer: 5-Year Outcomes of the KLASS-02 Randomized Clinical Trial – JAMA Surgery

Short-and long-term outcomes of laparoscopic versus open gastrectomy in patients with gastric cancer: a systematic review and meta-analysis of randomized controlled trials – World Journal of Surgical Oncology

Laparoscopic versus open distal gastrectomy for gastric cancer: A systematic review and meta-analysis – Surgery

Laparoscopic vs Open Distal Gastrectomy for Locally Advanced Gastric Cancer: Five-Year Outcomes From the CLASS-01 Randomized Clinical Trial – JAMA Surgery

Laparoscopic Versus Open Gastrectomy for Gastric Cancer (LOGICA): A Multicenter Randomized Clinical Trial – Journal of Clinical Oncology

Morbidity and Mortality of Laparoscopic vs Open Total Gastrectomy for Clinical Stage I Gastric Cancer: The CLASS02 Multicenter Randomized Clinical Trial – JAMA Oncology

Survival outcomes after laparoscopy-assisted distal gastrectomy versus open distal gastrectomy with nodal dissection for clinical stage IA or IB gastric cancer (JCOG0912): a multicentre, non-inferiority, phase 3 randomised controlled trial – The Lancet Gastroenterology & Hepatology

Effect of Laparoscopic Distal Gastrectomy vs Open Distal Gastrectomy on Long-term Survival Among Patients With Stage I Gastric Cancer: The KLASS-01 Randomized Clinical Trial – JAMA Oncology

 

Commentary on Twitter

 


M-A | Laparoscopic vs. open distal gastrectomy for locally advanced gastric cancer

15 Mar, 2023 | 14:52h | UTC

Laparoscopic vs. open distal gastrectomy for locally advanced gastric cancer: A systematic review and meta-analysis of randomized controlled trials – Frontiers in Surgery

Related:

Laparoscopic vs Open Distal Gastrectomy for Locally Advanced Gastric Cancer: 5-Year Outcomes of the KLASS-02 Randomized Clinical Trial – JAMA Surgery

Short-and long-term outcomes of laparoscopic versus open gastrectomy in patients with gastric cancer: a systematic review and meta-analysis of randomized controlled trials – World Journal of Surgical Oncology

Laparoscopic versus open distal gastrectomy for gastric cancer: A systematic review and meta-analysis – Surgery

Laparoscopic vs Open Distal Gastrectomy for Locally Advanced Gastric Cancer: Five-Year Outcomes From the CLASS-01 Randomized Clinical Trial – JAMA Surgery

Laparoscopic Versus Open Gastrectomy for Gastric Cancer (LOGICA): A Multicenter Randomized Clinical Trial – Journal of Clinical Oncology

Morbidity and Mortality of Laparoscopic vs Open Total Gastrectomy for Clinical Stage I Gastric Cancer: The CLASS02 Multicenter Randomized Clinical Trial – JAMA Oncology

Survival outcomes after laparoscopy-assisted distal gastrectomy versus open distal gastrectomy with nodal dissection for clinical stage IA or IB gastric cancer (JCOG0912): a multicentre, non-inferiority, phase 3 randomised controlled trial – The Lancet Gastroenterology & Hepatology

Effect of Laparoscopic Distal Gastrectomy vs Open Distal Gastrectomy on Long-term Survival Among Patients With Stage I Gastric Cancer: The KLASS-01 Randomized Clinical Trial – JAMA Oncology

 


Review | Analysis of deprescription strategies of proton pump inhibitors in primary care

7 Mar, 2023 | 12:42h | UTC

Analysis of deprescription strategies of proton pump inhibitors in primary care: a narrative review – Primary Health Care Research & Development

Related:

Deprescribing proton pump inhibitors – Australian Journal of General Practice

AGA Clinical Practice Update on De-Prescribing of Proton Pump Inhibitors: Expert Review – Gastroenterology

 


Review | Platelet aggregation inhibitors and anticoagulants in gastroenterological and visceral surgical procedures

1 Mar, 2023 | 14:03h | UTC

Platelet Aggregation Inhibitors and Anticoagulants in Gastroenterological and Visceral Surgical Procedures – Deutsches Ärzteblatt international

Related: Management of antiplatelet therapy in patients undergoing elective invasive procedures. Proposals from the French Working Group on perioperative haemostasis (GIHP) and the French Study Group on thrombosis and haemostasis (GFHT). In collaboration with the French Society for Anaesthesia and Intensive Care Medicine (SFAR)

 


Guideline | Diagnosis and treatment of Helicobacter pylori

24 Feb, 2023 | 13:53h | UTC

Helicobacter pylori World Gastroenterology Organization Global Guideline – Journal of Clinical Gastroenterology

Related:

AGA Clinical Practice Update on the Management of Refractory Helicobacter pylori Infection: Expert Review – Gastroenterology

Evidence based guidelines for the treatment of Helicobacter pylori infection in Korea 2020 – The Korean Journal of Internal Medicine

Management of Helicobacter pylori infection: Guidelines of the Italian Society of Gastroenterology (SIGE) and the Italian Society of Digestive Endoscopy (SIED) – Digestive and Liver Disease

 


RCT | Laparoscopic proximal gastrectomy with double-tract reconstruction vs. total gastrectomy in upper-third early gastric cancer

23 Feb, 2023 | 13:29h | UTC

Summary: This randomized trial examined whether laparoscopic proximal gastrectomy with double-tract reconstruction (LPG-DTR) is a superior surgical treatment compared to laparoscopic total gastrectomy (LTG) for patients with early gastric cancer (GC) in the upper third of the stomach. The study found that LPG-DTR resulted in significantly decreased amounts of vitamin B12 supplementation, but no significant difference in hemoglobin change compared to LTG. The study also found no difference in complication rates or overall and disease-free survival rates between the two groups. The study suggests that LPG-DTR may be a function-preserving procedure for the treatment of patients with upper-third early GC.

Article: Effect of Laparoscopic Proximal Gastrectomy With Double-Tract Reconstruction vs Total Gastrectomy on Hemoglobin Level and Vitamin B12 Supplementation in Upper-Third Early Gastric Cancer: A Randomized Clinical Trial – JAMA Network Open

 

Commentary on Twitter

 


M-A | Efficacy and safety of drugs for gastroparesis

17 Feb, 2023 | 13:05h | UTC

Efficacy and Safety of Drugs for Gastroparesis: Systematic Review and Network Meta-analysis – Gastroenterology

Commentaries:

Review finds only two efficacious medications to treat gastroparesis – ACP Gastroenterology

Two drug classes appear effective for gastroparesis treatment – MDedge

 

Commentary from the author on Twitter (thread – click for more)

 


Complications of diagnostic upper gastrointestinal endoscopy: recognition, assessment and management

7 Feb, 2023 | 13:41h | UTC

Complications of diagnostic upper Gastrointestinal endoscopy: common and rare – recognition, assessment and management – BMJ Open Gastroenterology

 


Review | Prevention and management of minor complications in percutaneous endoscopic gastrostomy

7 Feb, 2023 | 13:39h | UTC

Prevention and management of minor complications in percutaneous endoscopic gastrostomy – BMJ Open Gastroenterology

 


Rates of antimicrobial resistance in Helicobacter pylori isolates across the US and Europe

6 Feb, 2023 | 13:12h | UTC

Rates of Antimicrobial Resistance in Helicobacter pylori Isolates From Clinical Trial Patients Across the US and Europe – The American Journal of Gastroenterology

Commentary: Time to ditch clarithromycin for H. pylori? – MDedge

 

Commentary on Twitter

 


M-A | Short-and long-term outcomes of laparoscopic versus open gastrectomy in patients with gastric cancer

2 Feb, 2023 | 14:36h | UTC

Short-and long-term outcomes of laparoscopic versus open gastrectomy in patients with gastric cancer: a systematic review and meta-analysis of randomized controlled trials – World Journal of Surgical Oncology

 


M-A | Proximal gastrectomy with double-tract-reconstruction vs. total gastrectomy in gastric and gastroesophageal junction cancer patients

27 Jan, 2023 | 11:54h | UTC

Systematic review and meta-analysis comparing proximal gastrectomy with double-tract-reconstruction and total gastrectomy in gastric and gastroesophageal junction cancer patients: Still no sufficient evidence for clinical decision-making – Surgery

 


ACG Clinical Guideline | Diagnosis and management of gastrointestinal subepithelial lesions

18 Jan, 2023 | 14:39h | UTC

ACG Clinical Guideline: Diagnosis and Management of Gastrointestinal Subepithelial Lesions – The American Journal of Gastroenterology

Related: AGA Clinical Practice Update on Management of Subepithelial Lesions Encountered During Routine Endoscopy: Expert Review – Clinical Gastroenterology and Hepatology

 


RCT | Second-line levofloxacin-based quadruple therapy vs. bismuth-based quadruple therapy for Helicobacter pylori eradication

12 Jan, 2023 | 13:06h | UTC

Second-line levofloxacin-based quadruple therapy versus bismuth-based quadruple therapy for Helicobacter pylori eradication and long-term changes to the gut microbiota and antibiotic resistome: a multicentre, open-label, randomised controlled trial – The Lancet Gastroenterology & Hepatology (link to abstract – $ for full-text)

 

Commentary on Twitter

 


RCT | Assessment of spleen-preserving hilar lymphadenectomy for advanced proximal gastric cancer without invasion into the greater curvature.

15 Dec, 2022 | 13:30h | UTC

Assessment of Laparoscopic Spleen-Preserving Hilar Lymphadenectomy for Advanced Proximal Gastric Cancer Without Invasion Into the Greater Curvature: A Randomized Clinical Trial – JAMA Surgery (link to abstract – $ for full-text)

See also: Visual Abstract and Video Summary

 


Brief Review | Diagnosis and management of gastroparesis.

12 Dec, 2022 | 12:35h | UTC

Diagnosis and Management of Gastroparesis – The American Journal of Gastroenterology

Related:

Worldwide prevalence and burden of gastroparesis-like symptoms.

ACG Clinical Guideline: Gastroparesis – The American Journal of Gastroenterology

United European Gastroenterology (UEG) and European Society for Neurogastroenterology and Motility (ESNM) consensus on gastroparesis – UEG Journal

 


Post-trial follow-up | Bursectomy vs. omentectomy alone for resectable gastric cancer.

12 Dec, 2022 | 12:26h | UTC

Five-year follow-up of a randomized clinical trial comparing bursectomy and omentectomy alone for resectable gastric cancer (JCOG1001) – British Journal of Surgery (link to abstract – $ for full-text)

 


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