Neurosurgery
M-A: The diagnostic accuracy of noninvasive methods to measure the intracranial pressure
23 Feb, 2021 | 01:14h | UTC
Guidelines in the management of CNS tumors
23 Feb, 2021 | 01:09h | UTCGuidelines in the management of CNS tumors – Journal of Neuro-Oncology
RCT: Among children with Myelomeningocele, long term results confirm the benefits of prenatal repair compared to standard postnatal repair
10 Feb, 2021 | 01:28h | UTCPrenatal Repair and Physical Functioning Among Children With Myelomeningocele: A Secondary Analysis of a Randomized Clinical Trial – JAMA Pediatrics (free for a limited period)
Editorial: Long-term Outcomes of Children After Fetal Surgery for Spina Bifida—Toward Sustainability – JAMA Pediatrics (free for a limited period)
Commentaries: Spina Bifida Repair: The Sooner the Better – Physician’s Weekly AND Prenatal Myelomeningocele Repair Tied to Better Function – HealthDay
Commentary on Twitter
Previous work reported that prenatal versus postnatal repair of myelomeningocele resulted in improved physical functioning. A secondary analysis at #jamapeds reports that these improvements persist into school age. https://t.co/2aehk5L6pi pic.twitter.com/hASLEUcvqm
— JAMA Pediatrics (@JAMAPediatrics) February 9, 2021
Intraoperative imaging technology to maximize extent of resection for glioma: a network meta‐analysis
8 Feb, 2021 | 20:11h | UTC
Randomized trial: Safety and efficacy of long-term mild hypothermia for severe traumatic brain injury with refractory intracranial hypertension
4 Feb, 2021 | 01:18h | UTC
Commentary on Twitter
Does induced hypothermia/targetted temp management improve outcomes in patients with traumatic brain injury?
Maybe or maybe not
But this trial slow to cool, not very cool, underpowered and mod rate of dropout
Prob does not answer questionhttps://t.co/UGRFmUVNV0 pic.twitter.com/c0iDqj2l2e
— Graham Nichol (@grahamnichol) January 29, 2021
Meta-analysis: Beta-blockers for traumatic brain injury
28 Jan, 2021 | 01:18h | UTCBeta-blockers for traumatic brain injury: a systematic review and meta-analysis – Journal of Trauma and Acute Care Surgery (link to abstract – $ for full-text)
Observational study: Surgical decompression within 24 h of acute spinal cord injury is associated with improved sensorimotor recovery
13 Jan, 2021 | 01:49h | UTCThe influence of timing of surgical decompression for acute spinal cord injury: a pooled analysis of individual patient data – The Lancet Neurology (link to abstract – $ for full-text)
Commentary on Twitter
.@TheLancetNeuro Surgical decompression within one day of acute #spinalcordinjury is linked with improved sensorimotor recovery. The first 24-36 hours following injury seem to represent a crucial time frame to reach optimal #neurological recovery. @UofT https://t.co/Fi53K2YKBk pic.twitter.com/RDESblOgoM
— Neurology Today (@NeurologyToday) December 28, 2020
Randomized trial: Ultra-early tranexamic acid does not improve outcomes after subarachnoid hemorrhage
10 Jan, 2021 | 21:02h | UTCUltra-early tranexamic acid after subarachnoid haemorrhage (ULTRA): a randomised controlled trial – The Lancet (link to abstract – $ for full-text)
Tranexamic acid treatment in spontaneous subarachnoid haemorrhage, started immediately after CT diagnosis and continued until start of the aneurysm treatment as early as possible, does not improve clinical outcome, finds new randomised controlled trial: https://t.co/R0AhtszaY5 pic.twitter.com/Bnft9XgBA9
— The Lancet (@TheLancet) December 22, 2020
Randomized trial: Dexamethasone for chronic subdural hematoma resulted in fewer favorable outcomes and more adverse events than placebo at 6 months
17 Dec, 2020 | 09:02h | UTCTrial of Dexamethasone for Chronic Subdural Hematoma – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: Dexamethasone should be avoided in patients with chronic subdural haematoma – University of Cambridge AND Dexamethasone for Chronic Subdural Hematoma? – NEJM Journal Watch
Commentary on Twitter
In a trial that compared a 2-week course of dexamethasone with placebo in patients with a chronic subdural hematoma, a favorable outcome on the modified Rankin scale at 6 months was more common in the placebo group than in the dexamethasone group.
— NEJM (@NEJM) December 17, 2020
Review: Perioperative venous thromboembolism prophylaxis
3 Dec, 2020 | 08:28h | UTCPerioperative Venous Thromboembolism Prophylaxis – Mayo Clinic Proceedings
Tranexamic acid after traumatic brain injury: Exploratory analysis combining data from CRASH-2 and CRASH-3 trials suggests reduced mortality
13 Nov, 2020 | 09:21h | UTC
Commentary on Twitter
📊🔍 IPD meta-analysis of #CRASH2 and #CRASH3 trials show rapid #TXA (<3 hrs) reduces early deaths by >20% in both studies
Highly consistent results that #TXA reduces trauma deaths regardless of the location of the #bleeding 🩸
READ @Crit_Care 👉https://t.co/s3vkm6c6Tf pic.twitter.com/og9jYi5tqo
— Clinical Trials Unit (@CTU_LSHTM) November 11, 2020
Mechanical ventilation in patients with acute brain injury: recommendations of the European Society of Intensive Care Medicine consensus
13 Nov, 2020 | 09:19h | UTC
Review: Management of common postoperative complications
4 Nov, 2020 | 09:26h | UTCManagement of Common Postoperative Complications – Mayo Clinic Proceedings
Meta-analysis: Efficacy and safety of tranexamic acid in acute traumatic brain injury
22 Oct, 2020 | 09:31h | UTC
Commentary on Twitter
Tranexamic acid in acute TBI
➡️ 9 RCTs/14,747 pts
➡️ probably NO effect on mortality or disability
➡️ may decrease hematoma expansion on subsequent imaging (likely of minor importance to pts)
➡️ probably NO increased risk of adverse events#FOAMcc @yourICM https://t.co/sqn80NfNv4 pic.twitter.com/dMf8rYowC2— Intens Care Med (@yourICM) October 21, 2020
Case report: Cerebrospinal fluid leak after nasal swab testing for Covid-19
2 Oct, 2020 | 09:22h | UTC
C0mmentary on Twitter
There’s been a lot of joking about getting a nasopharyngeal swab can be like a brain biopsy. Well, that actually happened https://t.co/kczvr9lIFb @JAMAOto pic.twitter.com/Lio0yV0GkS
— Eric Topol (@EricTopol) October 1, 2020
NICE Guideline: Low back pain and sciatica in over 16s
23 Sep, 2020 | 14:41h | UTC
Randomized trial: Out-of-hospital tranexamic acid does not improve neurologic outcomes in patients with traumatic brain injury
9 Sep, 2020 | 09:20h | UTCEditorial: Out-of-Hospital Tranexamic Acid for Traumatic Brain Injury
Commentary on Twitter
In this phase II RCT prehospital tranexamic acid, which inhibits breakdown of fibrin clot, did not improve neurologic outcomes at 6 months vs placebo in patients with moderate to severe TBI https://t.co/PHK91YYxK3 @SusanRowellMD
— JAMA (@JAMA_current) September 8, 2020
Consensus recommendations on the prehospital care of the injured athlete with a suspected catastrophic cervical spine injury
21 Aug, 2020 | 02:16h | UTC
Guidelines for the management of severe traumatic brain injury: 2020 update of the decompressive craniectomy recommendations
10 Aug, 2020 | 01:46h | UTC
Cerebral Cavernous Malformation: What a Practicing Clinician Should Know
29 Jun, 2020 | 08:53h | UTCCerebral Cavernous Malformation: What a Practicing Clinician Should Know – Mayo Clinic Proceedings
Guidelines for the Acute Treatment of Cerebral Edema in Neurocritical Care Patients
11 Jun, 2020 | 09:21h | UTCSource: Critical Care Reviews
Framingham Heart Study: Assessment of Incidence and Risk Factors of Intracerebral Hemorrhage
10 Jun, 2020 | 04:42h | UTCAssessment of Incidence and Risk Factors of Intracerebral Hemorrhage Among Participants in the Framingham Heart Study Between 1948 and 2016 – JAMA Neurology (free for a limited period)
Review: Minimizing SARS-CoV-2 Exposure When Performing Surgical Interventions
28 May, 2020 | 09:42h | UTC
Analysis of Traumatic Brain Injury Lesions on Head CT Using Deep Learning
26 May, 2020 | 09:23h | UTCCommentaries: Deep learning: a turning point in acute neurology – The Lancet Digital Health
AI successfully used to identify different types of brain injuries – University of Cambridge AND Deep learning automatically measures key features of TBI – Health Imaging
Randomized Trial: Beta-Blocker Therapy Promising in Severe Traumatic Brain Injury
29 Apr, 2020 | 04:47h | UTCRelated Meta-Analysis: Beta-Blockers and Traumatic Brain Injury: A Systematic Review and Meta-Analysis – Annals of Surgery
“We recommend further high-quality trials to answer questions about the mechanisms of action, effectiveness on subgroups, dose-response, length of therapy, functional outcome, and quality of life after β-blocker use for TBI” (from the 2017 meta-analysis above)