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Antibiotic Stewardship

RCT: Prophylactic closed incision negative pressure wound therapy reduces (difference close to statistical significance; P=0.06) the risk of surgical site infection in obese women undergoing cesarean section.

7 May, 2021 | 08:24h | UTC

Closed incision negative pressure wound therapy versus standard dressings in obese women undergoing caesarean section: multicentre parallel group randomised controlled trial – The BMJ

 


ATS Guideline: Nucleic acid–based testing for noninfluenza viral pathogens in adults with suspected community-acquired pneumonia – Testing should be considered only in patients with severe CAP and in immunocompromised patients

5 May, 2021 | 08:28h | UTC

Nucleic Acid–based Testing for Noninfluenza Viral Pathogens in Adults with Suspected Community-acquired Pneumonia. An Official American Thoracic Society Clinical Practice Guideline

News Release: New clinical practice guideline on community acquired pneumonia – American Thoracic Society

 


Study: Most patients who develop a non-IgE-mediated hypersensitivity reaction to nafcillin can be safely treated with cefazolin

4 May, 2021 | 08:36h | UTC

Tolerability of Cefazolin in Nafcillin-Intolerant Patients for the Treatment of Methicillin-Susceptible Staphylococcus aureus Infections – Clinical Infectious Diseases

Related: Systematic Review and Meta-analysis of the Safety of Antistaphylococcal Penicillins Compared to Cefazolin – Antimicrobial Agents & Chemotherapy

 

Commentary on Twitter

 


ACG Clinical Guideline: Diagnosis and Management of Idiosyncratic Drug-Induced Liver Injury – antimicrobials, herbal and dietary supplements, and anticancer therapeutics are the most common classes of agents

3 May, 2021 | 05:22h | UTC

ACG Clinical Guideline: Diagnosis and Management of Idiosyncratic Drug-Induced Liver Injury – The American Journal of Gastroenterology

 


Study: Patients with heart failure have a much higher incidence of pneumonia than matched individuals in the population. The development of pneumonia in these patients is associated with a 3- to 4-fold higher risk of cardiovascular and all-cause death.

3 May, 2021 | 05:18h | UTC

Incidence and Outcomes of Pneumonia in Patients With Heart Failure – Journal of the American College of Cardiology

Commentaries: Pneumonia in HF Patients Is Common, Lethal, and Preventable – TCTMD AND Outcomes of Pneumonia in Patients With Heart Failure – American College of Cardiology

 


M-A: Delayed antibiotic prescribing for respiratory tract infections is a safe and effective strategy for most patients

30 Apr, 2021 | 08:33h | UTC

Delayed antibiotic prescribing for respiratory tract infections: individual patient data meta-analysis – The BMJ

Commentaries: Delayed Antibiotic Prescribing Safe for Respiratory Tract Infection – HealthDay

 


AHA Statement: Prevention of Viridans Group Streptococcal Infective Endocarditis – Antibiotic prophylaxis for invasive dental procedures is suggested only for high-risk patients with the following conditions: 1) cardiac prosthetic valve; 2) previous infective endocarditis; 3) congenital heart disease; or 4) previous heart transplant

30 Apr, 2021 | 08:35h | UTC

Prevention of Viridans Group Streptococcal Infective Endocarditis: A Scientific Statement From the American Heart Association

News release: Good dental health may help prevent heart infection from mouth bacteria – American Heart Association

Top Things to Know: Prevention of Viridans Group Streptococcal Infective Endocarditis – American Heart Association

Slide set: Prevention of Viridans Group Streptococcal Infective Endocarditis

Commentaries: Commentary for Prevention of Viridans Group Streptococcal Infective Endocarditis – American Heart Association

 

Commentary on Twitter (thread – click for more)

 


Guideline: Vulvovaginal Candidosis (Excluding Mucocutaneous Candidosis)

25 Apr, 2021 | 20:47h | UTC

Vulvovaginal Candidosis (Excluding Mucocutaneous Candidosis): Guideline of the German (DGGG), Austrian (OEGGG) and Swiss (SGGG) Society of Gynecology and Obstetrics (S2k-Level, AWMF Registry Number 015/072, September 2020) – Geburtshilfe und Frauenheilkunde

 


New-Generation Antibiotics for Treatment of Gram-Positive Infections: A Review with Focus on Endocarditis and Osteomyelitis

23 Apr, 2021 | 08:06h | UTC

New-Generation Antibiotics for Treatment of Gram-Positive Infections: A Review with Focus on Endocarditis and Osteomyelitis – Journal of Clinical Medicine

 


An Update on Eight “New” Antibiotics against Multidrug-Resistant Gram-Negative Bacteria

23 Apr, 2021 | 08:05h | UTC

An Update on Eight “New” Antibiotics against Multidrug-Resistant Gram-Negative Bacteria – Journal of Clinical Medicine

 


NICE Guideline | Neonatal infection: antibiotics for prevention and treatment

21 Apr, 2021 | 06:46h | UTC

Neonatal infection: antibiotics for prevention and treatment – National Institute for Health and Care Excellence

 


RCT: Effect of infusion set replacement intervals on catheter-related bloodstream infections – “Infusion set use can be safely extended to 7 days with resultant cost and workload reductions”

20 Apr, 2021 | 05:37h | UTC

Effect of infusion set replacement intervals on catheter-related bloodstream infections (RSVP): a randomised, controlled, equivalence (central venous access device)–non-inferiority (peripheral arterial catheter) trial – The Lancet (link to abstract – $ for full-text)

 

Commentaries on Twitter

 


WHO: Global shortage of innovative antibiotics fuels emergence and spread of drug-resistance

16 Apr, 2021 | 06:20h | UTC

News release: Global shortage of innovative antibiotics fuels emergence and spread of drug-resistance – World Health Organization

Report: 2020 antibacterial agents in clinical and preclinical development: an overview and analysis – World Health Organization

Commentary: WHO report highlights shortage of new antibiotics – CIDRAP

 


IDSA Guidance on the Treatment of ESBL Enterobacterales, Carbapenem-Resistant Enterobacterales, and Pseudomonas

13 Apr, 2021 | 05:11h | UTC

Infectious Diseases Society of America Guidance on the Treatment of Extended-Spectrum β-lactamase Producing Enterobacterales (ESBL-E), Carbapenem-Resistant Enterobacterales (CRE), and Pseudomonas aeruginosa with Difficult-to-Treat Resistance (DTR-P. aeruginosa) – Clinical Infectious Diseases

 


Cohort Study: Effects of fluoroquinolones on outcomes of patients with aortic dissection or aneurysm

13 Apr, 2021 | 05:05h | UTC

Effects of Fluoroquinolones on Outcomes of Patients With Aortic Dissection or Aneurysm – Journal of the American College of Cardiology

Commentary: Fluoroquinolones Associated With Increased Risk of Aortic Dissection, Aneurysm – American College of Cardiology

Related: Another study suggests fluoroquinolone use may increase the risk of development of aortic aneurysms (study and commentaries) AND Link between fluoroquinolones, aorta problems may not be as strong as thought AND Study: Oral Fluoroquinolones and Risk of Mitral and Aortic Regurgitation AND FDA Warns About Increased Risk of Aortic Dissection and Ruptures of Aortic Aneurism with Fluoroquinolones AND Meta-analysis: Fluoroquinolones and the Risk of Aortopathy AND Study: Oral Fluoroquinolone and the Risk of Aortic Dissection AND Research: Fluoroquinolone use and risk of aortic aneurysm and dissection

 


Consensus Document: Management of the complications of long term indwelling catheters

7 Apr, 2021 | 01:20h | UTC

British Association of Urological Surgeons (BAUS) and Nurses (BAUN) Consensus Document: Management of the Complications of Long Term Indwelling Catheters – BJU International

 


ACP Guidance: Appropriate Use of Short-Course Antibiotics in Common Infections

6 Apr, 2021 | 01:12h | UTC

Appropriate Use of Short-Course Antibiotics in Common Infections: Best Practice Advice From the American College of Physicians – Annals of Internal Medicine

Summary for Patients: Appropriate Use of Short-Course Antibiotics in Common Infections: Best Practice Advice From the American College of Physicians

News release: ACP best practice advice: Shorter course of antibiotics may be appropriate for some common infection – American College of Physicians

 


Many hospitalized Covid-19 patients are given antibiotics. That’s a problem

5 Apr, 2021 | 01:33h | UTC

Many hospitalized Covid-19 patients are given antibiotics. That’s a problem – STAT

 


Consensus Document: Management of superficial and deep surgical site infection

1 Apr, 2021 | 03:33h | UTC

Management of superficial and deep surgical site infection: an international multidisciplinary consensus – Updates in Surgery

Related Guidelines: Centers for Disease Control and Prevention Guideline for the Prevention of Surgical Site Infection, 2017 – JAMA Surgery AND Global guidelines on the prevention of surgical site infection – World Health Organization AND Surgical site infections: prevention and treatment – National Institute for Health and Care Excellence AND APSIC guidelines for the prevention of surgical site infections – Antimicrobial Resistance & Infection Control

 


Antimicrobial resistance in ICUs: an update in the light of the COVID-19 pandemic

30 Mar, 2021 | 03:21h | UTC

Antimicrobial resistance in ICUs: an update in the light of the COVID-19 pandemic – Current Opinion in Critical Care

 


RCT: Discontinuing betalactam treatment after 3 days as good as 8 days of treatment for stable patients with community-acquired pneumonia in non-critical care wards

28 Mar, 2021 | 22:25h | UTC

Discontinuing β-lactam treatment after 3 days for patients with community-acquired pneumonia in non-critical care wards (PTC): a double-blind, randomised, placebo-controlled, non-inferiority trial – The Lancet

 

Commentary on Twitter

 


State of the Art Review | Management of colonic diverticulitis

25 Mar, 2021 | 08:14h | UTC

Management of colonic diverticulitis – The BMJ

 

Commentary on Twitter

 


Review: Management of Staphylococcus aureus Bloodstream Infections

23 Mar, 2021 | 02:13h | UTC

Management of Staphylococcus aureus Bloodstream Infections – Frontiers in Medicine

Related: Treatment of methicillin-resistant Staphylococcus aureus (MRSA): updated guidelines from the UK – JAC-Antimicrobial Resistance

 


Nephrotoxicity from Vancomycin Combined with Piperacillin-Tazobactam: A Comprehensive Review

23 Mar, 2021 | 02:01h | UTC

Nephrotoxicity from Vancomycin Combined with Piperacillin-Tazobactam: A Comprehensive Review – American Journal of Nephrology

 


Systematic review: Prophylactic antibiotics for preventing pneumococcal infection in children with sickle cell disease

23 Mar, 2021 | 02:09h | UTC

Prophylactic antibiotics for preventing pneumococcal infection in children with sickle cell disease – Cochrane Library

 


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