Antibiotic Stewardship
Systematic Review: Parenteral Vitamin C in patients with severe infection.
24 Jun, 2022 | 11:49h | UTCParenteral Vitamin C in Patients with Severe Infection: A Systematic Review – NEJM Evidence
Related:
Is shorter always better? The pros and cons of treating Gram-negative bloodstream infections with 7 days of antibiotics.
24 Jun, 2022 | 11:38h | UTC
Retrospective Cohort Study: Prevalence and predictors of Pseudomonas aeruginosa among hospitalized patients with diabetic foot infections.
24 Jun, 2022 | 10:43h | UTC
Commentary on Twitter
Should Empiric DFI treatment include coverage for Pseudomonas aeruginosa?
🆕⚡Multicenter, retrospective cohort @OFIDJournal
257(88%) patients received empiric antibiotics active against PsA, but only 27 (9%) patients had PsA DFI #IDTwitter @BradSpellberg https://t.co/Ef5vD50LOD— Antibiotic Steward Bassam Ghanem🆔🔥 (@ABsteward) June 17, 2022
M-A: Incidence and etiology of infant Gram-negative bacteremia and meningitis in children.
23 Jun, 2022 | 10:27h | UTC
Position Paper: Diagnosis and management of infections caused by multidrug-resistant bacteria.
22 Jun, 2022 | 11:23h | UTCRelated Guideline:
RCT: Multispecies probiotic for the prevention of antibiotic-associated diarrhea in children.
22 Jun, 2022 | 11:12h | UTCMultispecies Probiotic for the Prevention of Antibiotic-Associated Diarrhea in Children: A Randomized Clinical Trial – JAMA Pediatrics (free for a limited period)
Commentary: Mixed Results With Probiotic for Kids’ Antibiotic-Related Diarrhea— Randomized trial misses strictly defined endpoint, but researchers point to benefit – MedPage Today (free registration required)
Commentary on Twitter
Study found administration of a multispecies #probiotic to children had no significant effect on the risk of antibiotic-associated diarrhea caused by #Cdifficile or of unknown etiology, but reduced the overall risk of diarrhea regardless of the etiology. https://t.co/Mdq3tl8csb
— JAMA Pediatrics (@JAMAPediatrics) June 21, 2022
RCT: Low-dose methylprednisolone does not improve outcomes in critically ill patients with severe community-acquired pneumonia.
21 Jun, 2022 | 11:04h | UTC
M-A: Accuracy of Fluorodeoxyglucose Positron Emission Tomography/ Computerized Tomography for diagnosing periprosthetic joint infections.
21 Jun, 2022 | 10:38h | UTC
RCT: A restrictive intravenous fluid strategy does not improve outcomes in ICU patients with septic shock.
20 Jun, 2022 | 10:51h | UTCRestriction of Intravenous Fluid in ICU Patients with Septic Shock – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: No Fewer Deaths Seen With Restricted IV Fluid for Septic Shock – HealthDay
Related:
Fluid administration and monitoring in ARDS: which management? – Intensive Care Medicine
Commentary on Twitter
In this trial, a restrictive approach to intravenous fluid administration in critically ill patients with septic shock did not reduce mortality. #CCR22 https://t.co/UfY1936Qwb pic.twitter.com/FtSaDIIroj
— NEJM (@NEJM) June 17, 2022
Does this patient with acute infectious conjunctivitis have a bacterial infection? The rational clinical examination systematic review.
17 Jun, 2022 | 11:12h | UTCDoes This Patient With Acute Infectious Conjunctivitis Have a Bacterial Infection? The Rational Clinical Examination Systematic Review – JAMA (free for a limited period)
Commentary on Twitter
In this review, bacterial conjunctivitis was more common than viral conjunctivitis in children and viral conjunctivitis was more common than bacterial conjunctivitis in adults, although the prevalence estimates were based on limited evidence. https://t.co/wJ6YXxPRem
— JAMA (@JAMA_current) June 16, 2022
NICE Guideline: Reducing sexually transmitted infections.
16 Jun, 2022 | 11:15h | UTCReducing sexually transmitted infections – National Institute for Health and Care Excellence
Review: Sepsis management for the nephrologist.
15 Jun, 2022 | 11:23h | UTCSepsis Management for the Nephrologist – Clinical Journal of the American Society of Nephrology
RCT: Vonoprazan triple and dual therapy for Helicobacter pylori infection.
15 Jun, 2022 | 10:41h | UTCVonoprazan Triple and Dual Therapy for Helicobacter pylori Infection in the US and Europe: Randomized Clinical Trial – Gastroenterology (link to abstract – $ for full-text)
Cohort Study: Prevalence, characteristics, and determinants of suboptimal care in the initial management of community-onset severe bacterial infections in children.
14 Jun, 2022 | 10:52h | UTC
Host-directed immunotherapy of viral and bacterial infections: past, present and future.
13 Jun, 2022 | 07:41h | UTCHost-directed immunotherapy of viral and bacterial infections: past, present and future – Nature Reviews Immunology (if the link is paywalled, try this one in PMC)
Commentary on Twitter
A Perspective in @NatRevImmunol reflects on the historical development of host-directed immunotherapeutic interventions for infections and how historical insights can be used in the therapy of SARS-CoV-2 and Mycobacterium tuberculosis infections. https://t.co/5WOXzePpFS pic.twitter.com/dpj1XNi2me
— Nature Portfolio (@NaturePortfolio) June 11, 2022
Guideline on management of diabetes-related foot infection.
10 Jun, 2022 | 11:51h | UTCRelated:
RCT: Effect of point-of-care testing for respiratory pathogens on antibiotic use in children.
10 Jun, 2022 | 11:16h | UTC
Commentary on Twitter
In a randomized controlled trial of 1243 children, point-of-care testing for respiratory pathogens did not reduce antibiotic consumption in acutely ill children. https://t.co/KnD4zRx2bf
— JAMA Network Open (@JAMANetworkOpen) June 9, 2022
Statement on initial antimicrobial treatment of sepsis.
8 Jun, 2022 | 11:17h | UTCStatement on initial antimicrobial treatment of sepsis – Faculty of Intensive Care Medicine
Commentary on Twitter
🚨Statement on initial antimicrobial treatment of sepsis🚨
Full statement and documents available➡️ https://t.co/jWexX1VDDd @AoMRC pic.twitter.com/kQdJrZ2hOA
— FICMNews (@FICMNews) June 4, 2022
Review: Timing of vasoactive agents and corticosteroid initiation in septic shock.
8 Jun, 2022 | 10:53h | UTCTiming of vasoactive agents and corticosteroid initiation in septic shock – Annals of Intensive Care
RCT: The effect of azithromycin on structural lung disease in infants with cystic fibrosis.
7 Jun, 2022 | 11:29h | UTCThe effect of azithromycin on structural lung disease in infants with cystic fibrosis (COMBAT CF): a phase 3, randomised, double-blind, placebo-controlled clinical trial – The Lancet Respiratory Medicine (link to abstract – $ for full-text)
Guidelines for management of Clostridioides (Clostridium) difficile infection.
3 Jun, 2022 | 11:28h | UTC
Exercise and acute respiratory infections: might regular exercise help protect us?
2 Jun, 2022 | 10:10h | UTCOriginal Study: Exercise versus no exercise for the occurrence, severity, and duration of acute respiratory infections – Cochrane Library
RCTs: Favipiravir treatment of uncomplicated influenza in adults.
1 Jun, 2022 | 11:27h | UTCCommentary: Mixed Bag for Antiviral Favipiravir in Flu — Two phase III trials show conflicting results on clinical improvement – MedPage Today (free registration required)
M-A: Prevalence of respiratory viruses in community-acquired pneumonia in children.
1 Jun, 2022 | 10:57h | UTCPrevalence of respiratory viruses in community-acquired pneumonia in children: a systematic review and meta-analysis – The Lancet Child & Adolescent Health (link to abstract – $ for full-text)
Commentary on Twitter
#Respiratory viruses are frequently detected in community-acquired #pneumonia among #children of all ages and geographical regions. Most common viruses were #RSV (23%) and #rhinovirus (22%) in the pre-COVID years
New Research by @MejbahBhuiyan & team: https://t.co/4ph2Isotcu
— The Lancet Child & Adolescent Health (@LancetChildAdol) May 31, 2022
Alcoholic chlorhexidine skin preparation or triclosan-coated sutures to reduce surgical site infection: a systematic review and meta-analysis of high-quality randomized controlled trials.
31 May, 2022 | 11:50h | UTCRelated Study: Reducing surgical site infections in low-income and middle-income countries (FALCON): a pragmatic, multicentre, stratified, randomised controlled trial – The Lancet AND Commentary: Expensive antiseptics and sutures do not reduce the risk of surgical infections – National Institute for Health and Care Research
Commentary from one of the authors on Twitter (thread – click for more)
1. Today: our @TheLancetInfDis meta-analysis based on @FalconRct – triclosan sutures and alcoholic skin prep to reduce surgical site infection.
Link to open access PDF:https://t.co/cj7yFdbNpB pic.twitter.com/VkKRaxCAtm
— Aneel Bhangu (@aneelbhangu) May 27, 2022