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Antibiotic Stewardship

Sepsis treatment: Another trial shows no benefit from the combination of Vitamin C, Thiamine, and Hydrocortisone

24 Feb, 2021 | 02:25h | UTC

Effect of Vitamin C, Thiamine, and Hydrocortisone on Ventilator- and Vasopressor-Free Days in Patients With Sepsis: The VICTAS Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Hydrocortisone, Vitamin C, and Thiamine for Treatment of Sepsis: Making Evidence Matter

Related: The VITAMINS Randomized Clinical Trial: Vitamin C, Hydrocortisone, and Thiamine Not beneficial for Patients with Sepsis (study and commentaries)


Commentary on Twitter


Diverticulitis: Observational study in outpatients suggests amoxicillin-clavulanate is a safe and effective option compared with metronidazole-fluoroquinolone

24 Feb, 2021 | 02:16h | UTC

Comparative Effectiveness and Harms of Antibiotics for Outpatient Diverticulitis: Two Nationwide Cohort Studies – Annals of Internal Medicine

Commentaries: Amoxicillin-clavulanate safe and effective compared with metronidazole-with-fluoroquinolone for diverticulitis – American College of Physicians AND Study supports fluoroquinolone-sparing treatment for diverticulitis – CIDRAP


Global guideline for the diagnosis and management of rare mold infections

19 Feb, 2021 | 02:18h | UTC

Global guideline for the diagnosis and management of rare mould infections: an initiative of the European Confederation of Medical Mycology in cooperation with the International Society for Human and Animal Mycology and the American Society for Microbiology – The Lancet Infectious Diseases (free for a limited period)


Commentary on Twitter


Serology anno 2021 – fungal infections: from invasive to chronic

17 Feb, 2021 | 01:19h | UTC

Serology anno 2021 – fungal infections: from invasive to chronic – Clinical Microbiology and Infection


Commentary on Twitter


Study: Obesity and risk of catheter-related infections in the ICU

16 Feb, 2021 | 01:46h | UTC

Obesity and risk of catheter-related infections in the ICU. A post hoc analysis of four large randomized controlled trials – Intensive Care Medicine


Commentary on Twitter


Corticosteroids for community acquired pneumonia, influenza and COVID-19: when, how and benefits or harm?

15 Feb, 2021 | 00:47h | UTC

Corticosteroids for CAP, influenza and COVID-19: when, how and benefits or harm? – European Respiratory Review


Randomized trial: Procalcitonin to reduce long-term infection-associated adverse events in sepsis

15 Feb, 2021 | 00:43h | UTC

Procalcitonin to Reduce Long-Term Infection-associated Adverse Events in Sepsis. A Randomized Trial – American Journal of Respiratory and Critical Care Medicine


RCT: Delayed antibiotic prescription feasible for children with uncomplicated respiratory infections

12 Feb, 2021 | 02:02h | UTC

Delayed Antibiotic Prescription for Children With Respiratory Infections: A Randomized Trial – Pediatrics (link to abstract – $ for full-text)

Commentary: Data support delayed antibiotics in kids with respiratory infections – CIDRAP


Cohort study: The use of macrolide antibiotics in pregnancy is not associated with an increased risk of major congenital malformations

12 Feb, 2021 | 02:04h | UTC

Association between use of macrolides in pregnancy and risk of major birth defects: nationwide, register based cohort study – The BMJ


Combination of vancomycin plus piperacillin and risk of acute kidney injury: a worldwide pharmacovigilance database analysis

11 Feb, 2021 | 01:50h | UTC

Combination of vancomycin plus piperacillin and risk of acute kidney injury: a worldwide pharmacovigilance database analysis – Journal of Antimicrobial Chemotherapy

Related: Risk of acute kidney injury and Clostridioides difficile infection with piperacillin/tazobactam, cefepime and meropenem with or without vancomycin – Clinical Infectious Diseases AND Vancomycin Plus Piperacillin-Tazobactam and Acute Kidney Injury in Adults: A Systematic Review and Meta-Analysis – Critical Care Medicine (link to abstract – $ for full-text) AND Association of Acute Kidney Injury With Concomitant Vancomycin and Piperacillin/Tazobactam Treatment Among Hospitalized Children – JAMA Pediatrics (link to abstract – $ for full-text) AND Co-administration of vancomycin and piperacillin-tazobactam is associated with increased renal dysfunction in adult and pediatric burn patients – Critical Care


Commentary on Twitter


RCT: Among patients undergoing transurethral resection of the prostate, it is safe to withhold antimicrobial prophylaxis for those without pre-operative pyuria or a pre-operative, indwelling catheter

11 Feb, 2021 | 01:52h | UTC

Antimicrobial Prophylaxis (AMP) in Transurethral Resection of the Prostate (TURP): Results of a Randomized Trial – The Journal of Urology


CDC study on practical ways for maximizing fit for masks to reduce SARS-CoV-2 transmission and exposure

11 Feb, 2021 | 02:25h | UTC

Maximizing Fit for Cloth and Medical Procedure Masks to Improve Performance and Reduce SARS-CoV-2 Transmission and Exposure, 2021 – Centers for Disease Control and Prevention

Commentaries: CDC Says Double-Masking Offers More Protection Against The Coronavirus – NPR AND CDC report: Double-masking can block more than 90 percent of viral particles – NBC News


Cohort study: Adjunctive clindamycin may benefit beta-lactam antibiotic-treated patients with invasive beta-hemolytic streptococcal infections

10 Feb, 2021 | 01:13h | UTC

Effectiveness of adjunctive clindamycin in β-lactam antibiotic-treated patients with invasive β-haemolytic streptococcal infections in US hospitals: a retrospective multicentre cohort study – The Lancet Infectious Diseases (link to abstract – $ for full-text)


Commentary on Twitter


Review: Nosocomial infection in the ICU setting

9 Feb, 2021 | 01:05h | UTC

Nosocomial Infection – Critical Care Medicine


RCT: Posaconazole noninferior to voriconazole for primary treatment of invasive aspergillosis

7 Feb, 2021 | 21:00h | UTC

Posaconazole versus voriconazole for primary treatment of invasive aspergillosis: a phase 3, randomised, controlled, non-inferiority trial – The Lancet (link to abstract – $ for full-text)


Report: The state of the world’s antibiotics report in 2021

7 Feb, 2021 | 20:49h | UTC

The State of the World’s Antibiotics Report in 2021 – The Center For Disease Dynamics, Economics & Policy

Commentary: Report highlights lack of progress against antimicrobial resistance – CIDRAP


SR/MA: Colistin nephrotoxicity

5 Feb, 2021 | 01:21h | UTC

Colistin Nephrotoxicity: Meta-analysis of Randomized Controlled Trials – Open Forum Infectious Diseases


Policy Statement: Antibiotic Stewardship in Pediatrics

4 Feb, 2021 | 01:21h | UTC

Antibiotic Stewardship in Pediatrics – Pediatrics

Commentary: Guidance Provided for Antibiotic Stewardship in Pediatrics


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