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Antibiotic Stewardship

CDC releases new guidelines for the treatment of sexually transmitted infections.

23 Jul, 2021 | 10:41h | UTC

Table of Contents: Sexually Transmitted Infections Treatment Guidelines, 2021

Guideline: Sexually Transmitted Infections Treatment Guidelines, 2021 – Centers for Disease Control and Prevention

Related (just released): WHO Guidelines for the management of symptomatic sexually transmitted infections.

 

Commentary on Twitter (thread – click for more)

 

WHO Guidelines for the management of symptomatic sexually transmitted infections.

22 Jul, 2021 | 10:54h | UTC

Guidelines for the management of symptomatic sexually transmitted infections – World Health Organization

News release: Launch WHO guidelines for the management of symptomatic sexually transmitted infection – World Health Organization

 

Commentary on Twitter

 

A Narrative Review on the Role of Staphylococcus aureus Bacteriuria in S. aureus Bacteremia.

22 Jul, 2021 | 10:37h | UTC

A Narrative Review on the Role of Staphylococcus aureus Bacteriuria in S. aureus Bacteremia – Open Forum Infectious Diseases

 

Commentary on Twitter

 

RCT: more data showing Azithromycin is not better than placebo in patients with Covid-19.

18 Jul, 2021 | 23:54h | UTC

Effect of Oral Azithromycin vs Placebo on COVID-19 Symptoms in Outpatients With SARS-CoV-2 Infection: A Randomized Clinical Trial – JAMA

Commentary: Common antibiotic no more effective than placebo in preventing COVID-19 symptoms among non-hospitalized – University of California – San Francisco

Related: RCT: Another study shows Azithromycin does not improve outcomes in patients with Covid-19. (several articles on the subject)

 

Commentary on Twitter

 

AAFP Guideline: Pharmacologic Management of COPD Exacerbations.

16 Jul, 2021 | 10:51h | UTC

Pharmacologic Management of COPD Exacerbations: A Clinical Practice Guideline from the AAFP – American Family Physician

 

Podcast | An Antibiotics Primer.

13 Jul, 2021 | 09:35h | UTC

#284 An Antibiotics Primer, with @IDdocAdi – The Curbsiders

 

Another RCT evaluating the efficacy and quality of life of antibiotic-only treatment of acute uncomplicated appendicitis.

13 Jul, 2021 | 09:33h | UTC

A Randomized Clinical Trial Evaluating the Efficacy and Quality of Life of Antibiotic-only Treatment of Acute Uncomplicated Appendicitis: Results of the COMMA Trial – Annals of Surgery (link to abstract – $ for full-text)

Related: A Randomized trial comparing antibiotics with appendectomy for appendicitis AND Antibiotics alone for uncomplicated appendicitis: Oral Moxifloxacin almost as good as intravenous Ertapenem + oral Levofloxacin AND Observational study: 67.1% success rate with nonoperative management of children with uncomplicated appendicitis AND Randomized Trial: Quality of Life and Patient Satisfaction at 7-Year Follow-up of Antibiotic Therapy vs. Appendectomy for Uncomplicated Acute Appendicitis AND Meta-Analysis: Antibiotic Treatment vs. Appendectomy for Uncomplicated Acute Appendicitis in Adults and Children AND Nonoperative treatment for nonperforated appendicitis in children: a systematic review and meta-analysis – Pediatric Surgery International

 

Commentary on Twitter

 

M-A: Similar mortality with Fluoroquinolones or Macrolides for the treatment of Legionella Pneumonia.

13 Jul, 2021 | 09:18h | UTC

Are Fluoroquinolones or Macrolides Better for Treating Legionella Pneumonia? A Systematic Review and Meta-analysis – Clinical Infectious Diseases (link to abstract – $ for full-text)

 

Understanding the Host in the Management of Pneumonia. An Official American Thoracic Society Workshop Report.

12 Jul, 2021 | 01:41h | UTC

Understanding the Host in the Management of Pneumonia. An Official American Thoracic Society Workshop Report – Annals of the American Thoracic Society

 

RCT: Another study shows that non-antibiotic outpatient treatment in mild acute diverticulitis is safe.

12 Jul, 2021 | 01:29h | UTC

Efficacy and Safety of Non-Antibiotic Outpatient Treatment in Mild Acute Diverticulitis (DINAMO-study): A Multicentre, Randomised, Open-Label, Non-Inferiority Trial – Annals of Surgery (link to abstract – $ for full-text)

Related: State of the Art Review: Management of colonic diverticulitis AND Treatment of Uncomplicated Acute Diverticulitis Without Antibiotics: A Systematic Review and Meta-analysis – Diseases of the Colon & Rectum AND Antibiotics Do Not Reduce Length of Hospital Stay for Uncomplicated Diverticulitis in a Pragmatic Double-Blind Randomized Trial – Clinical Gastroenterology and Hepatology AND Randomized Trial: Antibiotic Avoidance Associated with Similar Long-term Outcomes in Uncomplicated Diverticulitis

 

Commentary on Twitter

 

M-A: Acid suppression medications during hospitalization is a risk factor for recurrence of Clostridioides difficile infection.

9 Jul, 2021 | 09:59h | UTC

Acid Suppression Medications During Hospitalization as a Risk Factor for Recurrence of Clostridioides difficile Infection: Systematic Review and Meta-analysis – Clinical Infectious Diseases

 

M-A: Comparative efficacy and safety of vancomycin, linezolid, tedizolid, and daptomycin in treating patients with suspected or proven complicated skin and soft tissue infections.

9 Jul, 2021 | 09:57h | UTC

Comparative Efficacy and Safety of Vancomycin, Linezolid, Tedizolid, and Daptomycin in Treating Patients with Suspected or Proven Complicated Skin and Soft Tissue Infections: An Updated Network Meta-Analysis – Infectious Diseases and Therapy

 

Commentary on Twitter

 

Antibiotic resistance during and beyond COVID-19.

8 Jul, 2021 | 09:09h | UTC

Antibiotic resistance during and beyond COVID-19 – JAC-Antimicrobial Resistance

 

Study Commentary: Febrile Neutropenia – Procalcitonin vs. MASCC Score.

8 Jul, 2021 | 08:57h | UTC

Febrile Neutropenia – Procalcitonin vs MASCC Score – Journal Feed

Original study: Prognostic Value of Serum Procalcitonin Levels in Patients With Febrile Neutropenia Presenting to the Emergency Department – The Journal of Emergency Medicine

 

M-A: Are antimicrobial stewardship interventions effective and safe in long-term care facilities?

8 Jul, 2021 | 08:52h | UTC

Are antimicrobial stewardship interventions effective and safe in long-term care facilities? A systematic review and meta-analysis – Clinical Microbiology and Infection

 

RCT: An antibiotic-prescribing feedback to high-volume primary care physicians led to significant reductions in total and prolonged-duration antibiotic prescriptions, as well as drug costs.

7 Jul, 2021 | 08:47h | UTC

Effect of Antibiotic-Prescribing Feedback to High-Volume Primary Care Physicians on Number of Antibiotic Prescriptions: A Randomized Clinical Trial – JAMA Internal Medicine (free for a limited period)

Commentary: Studies highlight impact of clinician feedback on antibiotic prescribing – CIDRAP

 

Commentary on Twitter (thread – click for more)

 

IDSA Updated Covid-19 Guidance: Co-Infection and Antimicrobial Stewardship – “bacterial coinfections with SARS-CoV-2 infection are relatively infrequent (likely occurring in less than 10% of hospitalized COVID-19 patients)”.

28 Jun, 2021 | 09:51h | UTC

Co-Infection and Antimicrobial Stewardship – Infectious Diseases Society of America

Related: Another study shows a high frequency of antibiotic use among patients hospitalized with Covid-19 (85.2%), despite low rates of confirmed secondary bacterial infections.

 

Taskforce report on the diagnosis and clinical management of COVID-19 associated pulmonary aspergillosis.

25 Jun, 2021 | 10:37h | UTC

Taskforce report on the diagnosis and clinical management of COVID-19 associated pulmonary aspergillosis – Intensive Care Medicine

 

Commentary on Twitter

 

RCT: Doxycycline for 7 days superior to single-dose azithromycin for the treatment of rectal chlamydia infection.

25 Jun, 2021 | 10:19h | UTC

Azithromycin or Doxycycline for Asymptomatic Rectal Chlamydia trachomatis – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Doxycycline Superior to Azithromycin for Asymptomatic Rectal Chlamydia in Men – Physician’s Weekly

 

Commentary on Twitter

 

IDSA 2021 focused update guidelines on the management of Clostridioides difficile infection in adults.

25 Jun, 2021 | 10:17h | UTC

Clinical Practice Guideline by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA): 2021 Focused Update Guidelines on Management of Clostridioides difficile Infection in Adults – Clinical Infectious Diseases

News release: IDSA And SHEA Release New Guidelines for Managing Clostridium Difficile Infection – Infectious Diseases Society of America

 

Commentary on Twitter

 

Review | My Treatment Approach to Clostridioides difficile Infection.

24 Jun, 2021 | 09:47h | UTC

My Treatment Approach to Clostridioides difficile Infection – Mayo Clinic Proceedings

 

WHO Report: Global antimicrobial resistance and use surveillance system.

11 Jun, 2021 | 08:22h | UTC

Global Antimicrobial Resistance and Use Surveillance System (GLASS) Report: 2021 – World Health Organization

News Release: Record response to WHO’s call for antimicrobial resistance surveillance reports in 2020 – World Health Organization

Commentary: WHO reveals new global antibiotic resistance data, more concerns – CIDRAP

 

Commentary on Twitter (thread – click for more)

 

Time-to-positivity in bloodstream infection is not a prognostic marker for mortality: analysis of a prospective multicenter randomized control trial.

8 Jun, 2021 | 09:21h | UTC

Time-to-positivity in bloodstream infection is not a prognostic marker for mortality: analysis of a prospective multicentre randomised control trial – Clinical Microbiology and Infections

 

Commentary on Twitter

 

Opinion | “Doctors have been blamed for the rise in black fungus in India, but the COVID treatment guidelines could be contributing” – improper use of antibiotics and higher than usual doses of corticosteroids may be contributing to the emergence of mucormycosis and other fungal co-infections.

6 Jun, 2021 | 23:48h | UTC

Doctors have been blamed for the rise in black fungus in India, but the COVID treatment guidelines could be contributing – The Conversation

See also: Rising incidence of mucormycosis in patients with COVID-19: another challenge for India amidst the second wave? – The Lancet Respiratory Medicine

Related: The Emergence of COVID-19 Associated Mucormycosis: Analysis of Cases From 18 Countries – The Lancet AND What Is ‘Black Fungus’? And Why Is It Spreading Among India’s COVID Patients? – NPR AND Mucormycosis: The ‘black fungus’ maiming Covid patients in India AND What is mucormycosis, the fungal infection affecting COVID patients in India? – The Conversation

 

Another study shows a high frequency of antibiotic use among patients hospitalized with Covid-19 (85.2%), despite low rates of confirmed secondary bacterial infections.

4 Jun, 2021 | 10:43h | UTC

Co-infections, secondary infections, and antimicrobial use in patients hospitalised with COVID-19 during the first pandemic wave from the ISARIC WHO CCP-UK study: a multicentre, prospective cohort study – The Lancet Microbe

Commentaries: Very high use of antibiotics in COVID-19 treatment could be reduced – University of Glasgow AND More evidence of frequent antibiotic use noted in COVID patients – CIDRAP AND Covid-19: Antimicrobial use was high during first wave despite bacterial co-infections being rare, study finds – The BMJ

Related: Many hospitalized Covid-19 patients are given antibiotics. That’s a problem – STAT

 

Commentary on Twitter (thread – click for more)

 

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