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Antibiotic Stewardship

Systematic Review: Parenteral Vitamin C in patients with severe infection.

24 Jun, 2022 | 11:49h | UTC

Parenteral Vitamin C in Patients with Severe Infection: A Systematic Review – NEJM Evidence

Related:

Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit – New England Journal of Medicine

Effect of adjunctive vitamin C, glucocorticoids, and vitamin B1 on longer-term mortality in adults with sepsis or septic shock: a systematic review and a component network meta-analysis – Intensive Care Medicine

Effect of Vitamin C, Thiamine, and Hydrocortisone on Ventilator- and Vasopressor-Free Days in Patients With Sepsis: The VICTAS Randomized Clinical Trial – JAMA

Effect of Vitamin C, Hydrocortisone, and Thiamine vs Hydrocortisone Alone on Time Alive and Free of Vasopressor Support Among Patients With Septic Shock: The VITAMINS Randomized Clinical Trial – JAMA

 


Is shorter always better? The pros and cons of treating Gram-negative bloodstream infections with 7 days of antibiotics.

24 Jun, 2022 | 11:38h | UTC

Is shorter always better? The pros and cons of treating Gram-negative bloodstream infections with 7 days of antibiotics – JAC-Antimicrobial Resistance

 


Retrospective Cohort Study: Prevalence and predictors of Pseudomonas aeruginosa among hospitalized patients with diabetic foot infections.

24 Jun, 2022 | 10:43h | UTC

Prevalence and Predictors of Pseudomonas aeruginosa among Hospitalized Patients with Diabetic Foot Infections – Open Forum Infectious Diseases

 

Commentary on Twitter

 


M-A: Incidence and etiology of infant Gram-negative bacteremia and meningitis in children.

23 Jun, 2022 | 10:27h | UTC

Incidence and aetiology of infant Gram-negative bacteraemia and meningitis: systematic review and meta-analysis – Archives of Disease in Childhood

 


Position Paper: Diagnosis and management of infections caused by multidrug-resistant bacteria.

22 Jun, 2022 | 11:23h | UTC

A position paper for the diagnosis and management of infections caused by multidrug-resistant bacteria: Endorsed by the Italian Society of Infection and Tropical Diseases (SIMIT), the Italian Society of Anti-Infective Therapy (SITA), the Italian Group for Antimicrobial Stewardship (GISA), the Italian Association of Clinical Microbiologists (AMCLI), and the Italian Society of Microbiology (SIM) – International Journal of Antimicrobial Agents

Related Guideline:

IDSA Guidance on the Treatment of Antimicrobial-Resistant Gram-Negative Infections: Version 2.0 – Infectious Diseases Society of America

IDSA Guidance on the Treatment of Antimicrobial-Resistant Gram-Negative Infections: Version 1.0 – Infectious Diseases Society of America

 


RCT: Multispecies probiotic for the prevention of antibiotic-associated diarrhea in children.

22 Jun, 2022 | 11:12h | UTC

Multispecies Probiotic for the Prevention of Antibiotic-Associated Diarrhea in Children: A Randomized Clinical Trial – JAMA Pediatrics (free for a limited period)

Commentary: Mixed Results With Probiotic for Kids’ Antibiotic-Related Diarrhea— Randomized trial misses strictly defined endpoint, but researchers point to benefit – MedPage Today (free registration required)

 

Commentary on Twitter

 


RCT: Low-dose methylprednisolone does not improve outcomes in critically ill patients with severe community-acquired pneumonia.

21 Jun, 2022 | 11:04h | UTC

Low-dose methylprednisolone treatment in critically ill patients with severe community-acquired pneumonia – Intensive Care Medicine

 


M-A: Accuracy of Fluorodeoxyglucose Positron Emission Tomography/ Computerized Tomography for diagnosing periprosthetic joint infections.

21 Jun, 2022 | 10:38h | UTC

A Systematic Review and Meta-Analysis on the Accuracy of Fluorodeoxyglucose Positron Emission Tomography/ Computerized Tomography for Diagnosing Periprosthetic Joint Infections – Frontiers in Surgery

 


RCT: A restrictive intravenous fluid strategy does not improve outcomes in ICU patients with septic shock.

20 Jun, 2022 | 10:51h | UTC

Restriction of Intravenous Fluid in ICU Patients with Septic Shock – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: No Fewer Deaths Seen With Restricted IV Fluid for Septic Shock – HealthDay

Related:

Restrictive versus Liberal Fluid Therapy for Major Abdominal Surgery – New England Journal of Medicine

Effect of Slower vs Faster Intravenous Fluid Bolus Rates on Mortality in Critically Ill Patients: The BaSICS Randomized Clinical Trial – JAMA

Fluid administration and monitoring in ARDS: which management? – Intensive Care Medicine

Perioperative liberal versus restrictive fluid strategies and postoperative outcomes: a systematic review and metanalysis on randomised-controlled trials in major abdominal elective surgery – Critical Care

 

Commentary on Twitter

 


Does this patient with acute infectious conjunctivitis have a bacterial infection? The rational clinical examination systematic review.

17 Jun, 2022 | 11:12h | UTC

Does This Patient With Acute Infectious Conjunctivitis Have a Bacterial Infection? The Rational Clinical Examination Systematic Review – JAMA (free for a limited period)

 

Commentary on Twitter

 


NICE Guideline: Reducing sexually transmitted infections.

16 Jun, 2022 | 11:15h | UTC

Reducing sexually transmitted infections – National Institute for Health and Care Excellence

 


Review: Sepsis management for the nephrologist.

15 Jun, 2022 | 11:23h | UTC

Sepsis Management for the Nephrologist – Clinical Journal of the American Society of Nephrology

 


RCT: Vonoprazan triple and dual therapy for Helicobacter pylori infection.

15 Jun, 2022 | 10:41h | UTC

Vonoprazan Triple and Dual Therapy for Helicobacter pylori Infection in the US and Europe: Randomized Clinical Trial – Gastroenterology (link to abstract – $ for full-text)

 


Cohort Study: Prevalence, characteristics, and determinants of suboptimal care in the initial management of community-onset severe bacterial infections in children.

14 Jun, 2022 | 10:52h | UTC

Prevalence, Characteristics, and Determinants of Suboptimal Care in the Initial Management of Community-Onset Severe Bacterial Infections in Children – JAMA Network Open

 


Host-directed immunotherapy of viral and bacterial infections: past, present and future.

13 Jun, 2022 | 07:41h | UTC

Host-directed immunotherapy of viral and bacterial infections: past, present and future – Nature Reviews Immunology (if the link is paywalled, try this one in PMC)

 

Commentary on Twitter

 


Guideline on management of diabetes-related foot infection.

10 Jun, 2022 | 11:51h | UTC

Australian guideline on management of diabetes-related foot infection: part of the 2021 Australian evidence-based guidelines for diabetes-related foot disease – Journal of Foot and Ankle Research

Related:

Australian guideline on wound classification of diabetes-related foot ulcers: part of the 2021 Australian evidence-based guidelines for diabetes-related foot disease

Australian guideline on wound healing interventions to enhance healing of foot ulcers: part of the 2021 Australian evidence-based guidelines for diabetes-related foot disease

Australian guideline on offloading treatment for foot ulcers: part of the 2021 Australian evidence-based guidelines for diabetes-related foot disease

 


RCT: Effect of point-of-care testing for respiratory pathogens on antibiotic use in children.

10 Jun, 2022 | 11:16h | UTC

Effect of Point-of-Care Testing for Respiratory Pathogens on Antibiotic Use in Children: A Randomized Clinical Trial – JAMA Network Open

 

Commentary on Twitter

 


Statement on initial antimicrobial treatment of sepsis.

8 Jun, 2022 | 11:17h | UTC

Statement on initial antimicrobial treatment of sepsis – Faculty of Intensive Care Medicine

 

Commentary on Twitter

 


Review: Timing of vasoactive agents and corticosteroid initiation in septic shock.

8 Jun, 2022 | 10:53h | UTC

Timing of vasoactive agents and corticosteroid initiation in septic shock – Annals of Intensive Care

 


RCT: The effect of azithromycin on structural lung disease in infants with cystic fibrosis.

7 Jun, 2022 | 11:29h | UTC

The effect of azithromycin on structural lung disease in infants with cystic fibrosis (COMBAT CF): a phase 3, randomised, double-blind, placebo-controlled clinical trial – The Lancet Respiratory Medicine (link to abstract – $ for full-text)

 


Guidelines for management of Clostridioides (Clostridium) difficile infection.

3 Jun, 2022 | 11:28h | UTC

Japanese Clinical Practice Guidelines for Management of Clostridioides (Clostridium) difficile infection – Journal of Infection and Chemotherapy

 


Exercise and acute respiratory infections: might regular exercise help protect us?

2 Jun, 2022 | 10:10h | UTC

Exercise and acute respiratory infections: might regular exercise help protect us? – Evidently Cochrane

Original Study: Exercise versus no exercise for the occurrence, severity, and duration of acute respiratory infections – Cochrane Library

 


RCTs: Favipiravir treatment of uncomplicated influenza in adults.

1 Jun, 2022 | 11:27h | UTC

Favipiravir Treatment of Uncomplicated Influenza in Adults: Results of Two Phase 3, Randomized, Double-Blind, Placebo-Controlled Trials – Journal of Infectious Diseases

Commentary: Mixed Bag for Antiviral Favipiravir in Flu — Two phase III trials show conflicting results on clinical improvement – MedPage Today (free registration required)

 


M-A: Prevalence of respiratory viruses in community-acquired pneumonia in children.

1 Jun, 2022 | 10:57h | UTC

Prevalence of respiratory viruses in community-acquired pneumonia in children: a systematic review and meta-analysis – The Lancet Child & Adolescent Health (link to abstract – $ for full-text)

 

Commentary on Twitter

 


Alcoholic chlorhexidine skin preparation or triclosan-coated sutures to reduce surgical site infection: a systematic review and meta-analysis of high-quality randomized controlled trials.

31 May, 2022 | 11:50h | UTC

Alcoholic chlorhexidine skin preparation or triclosan-coated sutures to reduce surgical site infection: a systematic review and meta-analysis of high-quality randomised controlled trials – The Lancet Infectious Diseases

Related Study: Reducing surgical site infections in low-income and middle-income countries (FALCON): a pragmatic, multicentre, stratified, randomised controlled trial – The Lancet AND Commentary: Expensive antiseptics and sutures do not reduce the risk of surgical infections – National Institute for Health and Care Research

 

Commentary from one of the authors on Twitter (thread – click for more)

 


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