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Antibiotic Stewardship

Review | The blood–brain barrier and optimization of antibiotics for the treatment of CNS infections in adults

27 Jan, 2023 | 11:55h | UTC

The Blood–Brain Barrier and Pharmacokinetic/Pharmacodynamic Optimization of Antibiotics for the Treatment of Central Nervous System Infections in Adults – Antibiotics

 


RCT | 2 days of postoperative antibiotics is noninferior to 5 days in patients with complex appendicitis

24 Jan, 2023 | 14:33h | UTC

2 days versus 5 days of postoperative antibiotics for complex appendicitis: a pragmatic, open-label, multicentre, non-inferiority randomised trial – The Lancet (link to abstract – $ for full-text)

Commentary: Trial supports shorter postoperative antibiotics for complex appendicitis – CIDRAP

 

Commentary on Twitter

 


ASCO Guideline | Management of fever and neutropenia in pediatric patients with cancer and hematopoietic cell transplantation recipients

24 Jan, 2023 | 14:28h | UTC

Guideline for the Management of Fever and Neutropenia in Pediatric Patients With Cancer and Hematopoietic Cell Transplantation Recipients: 2023 Update – Journal of Clinical Oncology

 


Recommendations for the diagnosis and management of COVID-19 associated bacterial and fungal infections

20 Jan, 2023 | 14:48h | UTC

Recommendations and guidelines for the diagnosis and management of Coronavirus Disease-19 (COVID-19) associated bacterial and fungal infections in Taiwan – Journal of Microbiology, Immunology and Infection

 


RCT | Aqueous povidone-iodine vs. normal saline for intraoperative wound irrigation on the incidence of SSI after GI surgery

19 Jan, 2023 | 13:54h | UTC

Aqueous Povidone-Iodine Versus Normal Saline For Intraoperative Wound Irrigation On The Incidence Of Surgical Site Infection In Clean-Contaminated Wounds After Gastroenterological Surgery: A Single Institute, Prospective, Blinded-Endpoint, Randomized Controlled Trial – Annals of Surgery (link to abstract – $ for full-text)

 


Review | Surgical site infection prevention

18 Jan, 2023 | 14:31h | UTC

Surgical Site Infection Prevention: A Review – JAMA (free for a limited period)

Author interview: Surgical Site Infection Prevention – JAMA

Related:

Centers for Disease Control and Prevention Guideline for the Prevention of Surgical Site Infection, 2017 – JAMA Surgery 

Global guidelines on the prevention of surgical site infection – World Health Organization 

Surgical site infections: prevention and treatment – National Institute for Health and Care Excellence 

APSIC guidelines for the prevention of surgical site infections – Antimicrobial Resistance & Infection Control

Perioperative care bundles for the prevention of surgical-site infections: meta-analysis – British Journal of Surgery

AAOS Guideline: Prevention of surgical site infections after major extremity trauma.

 


Consensus statement | Use of a 4-month treatment regimen for drug susceptible TB in children with uncomplicated disease

18 Jan, 2023 | 14:25h | UTC

Consensus statement on the use of a four-month treatment regimen for drug susceptible tuberculosis in children (< 10 years of age) with uncomplicated disease – Australian Government Department of Health and Aged Care

 


SR | Pre‐emptive antifungal therapy vs. empirical antifungal therapy for febrile neutropenia in people with cancer

18 Jan, 2023 | 14:18h | UTC

Pre‐emptive antifungal therapy versus empirical antifungal therapy for febrile neutropenia in people with cancer – Cochrane Library

Summary: Pre-emptive versus empirical antifungal therapy in people with cancer who have febrile neutropenia – Cochrane Library

 


SHEA statement on antibiotic stewardship in hospitals during public health emergencies

17 Jan, 2023 | 13:18h | UTC

SHEA statement on antibiotic stewardship in hospitals during public health emergencies – Infection Control & Hospital Epidemiology 

 


Review | Viral infections in critical care

17 Jan, 2023 | 13:01h | UTC

Viral infections in critical care: a narrative review – Anaesthesia

 


M-A | Colonisation with ESCR-Enterobacterales and infection risk in surgical patients

17 Jan, 2023 | 12:58h | UTC

Colonisation with Extended-Spectrum Cephalosporin-Resistant Enterobacterales and Infection Risk in Surgical Patients: A Systematic Review and Meta-analysis – Infectious Diseases and Therapy

 


Best infectious diseases articles from 2022 – A year end review of non-COVID literature

15 Jan, 2023 | 20:31h | UTC

Best Infectious Diseases Articles From 2022 – A Year End Review Of Non-COVID Literature – IDstewardship

 

Commentary on Twitter

 


RCT | Colistin monotherapy vs. combination therapy for carbapenem-resistant organisms

13 Jan, 2023 | 13:36h | UTC

Colistin Monotherapy versus Combination Therapy for Carbapenem-Resistant Organisms – NEJM Evidence

Commentary: Colistin Alone or with Meropenem: Is More Better? – NEJM Journal Watch

Related: Colistin alone versus colistin plus meropenem for treatment of severe infections caused by carbapenem-resistant Gram-negative bacteria: an open-label, randomised controlled trial – The Lancet

 


Study suggests delivering high concentrations of antibiotics into the implantation site is feasible for infections in implanted CV electronic devices

13 Jan, 2023 | 13:26h | UTC

Regional Antibiotic Delivery for Implanted Cardiovascular Electronic Device Infections – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentaries: 

Direct Delivery of Antibiotics to CV Device Pocket Infections Appears Promising – TCTMD

Regional Antibiotics for Implanted Cardiovascular Electronic Device Infections – American College of Cardiology

 


Cohort Study | Antibiotic exposure linked to increased risk of inflammatory bowel disease

13 Jan, 2023 | 13:25h | UTC

Antibiotic use as a risk factor for inflammatory bowel disease across the ages: a population-based cohort study – Gut

News Release: Frequent use of antibiotics may heighten inflammatory bowel disease risk in over 40s – BMJ Newsroom

Commentaries: 

Antibiotics may increase risk of inflammatory bowel disease, study finds – CIDRAP

Antibiotic Exposure Positively Linked to IBD Development – HealthDay

 

Commentary on Twitter

 


RCT | Second-line levofloxacin-based quadruple therapy vs. bismuth-based quadruple therapy for Helicobacter pylori eradication

12 Jan, 2023 | 13:06h | UTC

Second-line levofloxacin-based quadruple therapy versus bismuth-based quadruple therapy for Helicobacter pylori eradication and long-term changes to the gut microbiota and antibiotic resistome: a multicentre, open-label, randomised controlled trial – The Lancet Gastroenterology & Hepatology (link to abstract – $ for full-text)

 

Commentary on Twitter

 


SR | Interventions for the eradication of methicillin‐resistant Staphylococcus aureus (MRSA) in people with cystic fibrosis

12 Jan, 2023 | 13:04h | UTC

Interventions for the eradication of meticillin‐resistant Staphylococcus aureus (MRSA) in people with cystic fibrosis – Cochrane Library

 


Review | Early diagnosis and prevention of infections in cirrhosis

12 Jan, 2023 | 12:47h | UTC

Early Diagnosis and Prevention of Infections in Cirrhosis – Seminars in Liver Disease

 


RCT | Efficacy and safety of azithromycin vs. placebo to treat lower respiratory tract infections associated with low procalcitonin.

16 Dec, 2022 | 13:30h | UTC

Efficacy and safety of azithromycin versus placebo to treat lower respiratory tract infections associated with low procalcitonin: a randomised, placebo-controlled, double-blind, non-inferiority trial – The Lancet Infectious Diseases (link to abstract – $ for full-text) 

Commentary: Study Evaluates Biomarker to Help Curb Unnecessary Antibiotic Use: Placebo Worse Than Antibiotics After 5 Days, But Similar at Day 11 – Duke Health

 

Commentary on Twitter

 


SR | Treatment of enteric fever (typhoid and paratyphoid fever) with cephalosporins.

14 Dec, 2022 | 14:51h | UTC

Treatment of enteric fever (typhoid and paratyphoid fever) with cephalosporins – Cochrane Library

 


Prevention of device-related infections in patients with cancer: Current practice and future horizons.

13 Dec, 2022 | 14:30h | UTC

Prevention of device-related infections in patients with cancer: Current practice and future horizons – CA: A Cancer Journal for Clinicians

 


WHO Report signals increasing resistance to antibiotics in bacterial infections in humans.

12 Dec, 2022 | 12:52h | UTC

News Release: Report signals increasing resistance to antibiotics in bacterial infections in humans and need for better data – World Health Organization

Report: Global antimicrobial resistance and use surveillance system (‎GLASS)‎ report: 2022 – World Health Organization

Commentary: WHO report shows rising antibiotic resistance, need for better data – CIDRAP

 

Commentary on Twitter (thread – click for more)

 


Approach to fever in patients with neutropenia: a review of diagnosis and management.

8 Dec, 2022 | 12:44h | UTC

Approach to fever in patients with neutropenia: a review of diagnosis and management – Therapeutic Advances in Infectious Disease

Related:

The Dutch Working Party on Antibiotic Policy (SWAB) Recommendations for the Diagnosis and Management of Febrile Neutropenia in Patients with Cancer – Infectious Diseases and Therapy

Outpatient Management of Fever and Neutropenia in Adults Treated for Malignancy: American Society of Clinical Oncology and Infectious Diseases Society of America Clinical Practice Guideline Update – Journal of Clinical Oncology

Management of sepsis in neutropenic cancer patients: 2018 guidelines from the Infectious Diseases Working Party (AGIHO) and Intensive Care Working Party (iCHOP) of the German Society of Hematology and Medical Oncology (DGHO) – Annals of Hematology

SEOM clinical practice guideline: management and prevention of febrile neutropenia in adults with solid tumors (2018) – Clinical and Translational Oncology

Diagnosis and empirical treatment of fever of unknown origin (FUO) in adult neutropenic patients: guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Medical Oncology (DGHO)

Guideline for the Management of Fever and Neutropenia in Children With Cancer and Hematopoietic Stem-Cell Transplantation Recipients: 2017 Update

 


Podcast | Procalcitonin revisited.

7 Dec, 2022 | 14:17h | UTC

Annals On Call – Procalcitonin Revisited – Annals of Internal Medicine

 


RCT | Efficacy of postoperative oral cephalexin and metronidazole on SSI in obese women undergoing cesarean section.

7 Dec, 2022 | 14:13h | UTC

Effectiveness of postoperative oral administration of cephalexin and metronidazole on surgical site infection among obese women undergoing cesarean section: a randomized, double-blind, placebo-controlled, parallel-group study-phase III – Antimicrobial Resistance & Infection Control

 


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