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Oncology – Breast

Cohort Study | Potential negative survival impact of PPI and palbociclib co-administration in breast cancer patients

8 Aug, 2023 | 13:07h | UTC

Concomitant Use of Proton Pump Inhibitors and Palbociclib Among Patients With Breast Cancer – JAMA Network Open

Commentary: Proton Pump Inhibitors May Compromise Efficacy of Palbociclib in Patients With Breast Cancer – Cancer Therapy Advisor

 


RCT | Mammography screening with AI reduces workload by 44.3% without loss in detection efficacy

4 Aug, 2023 | 12:13h | UTC

Artificial intelligence-supported screen reading versus standard double reading in the Mammography Screening with Artificial Intelligence trial (MASAI): a clinical safety analysis of a randomised, controlled, non-inferiority, single-blinded, screening accuracy study – The Lancet Oncology (link to abstract – $ for full-text)

News Release: First randomized trial finds AI-supported mammography screening is safe and almost halves radiologist workload – Lancet

Commentaries:

Large Mammography Study Shows Significant Benefits with AI-Aided Screening – Diagnostic Imaging

Expert reaction to interim safety analysis of randomised trial on AI-supported mammography screening – Science Media Centre

 


Systematic Review | Interstitial lung disease incidence at 11.7% in metastatic breast cancer patients using trastuzumab deruxtecan

3 Aug, 2023 | 13:36h | UTC

Incidence of interstitial lung disease and cardiotoxicity with trastuzumab deruxtecan in breast cancer patients: a systematic review and single-arm meta-analysis – ESMO Open

 


Review | Atypical hyperplasia of the breast: Clinical cases and management strategies

3 Aug, 2023 | 13:07h | UTC

Atypical hyperplasia of the breast: Clinical cases and management strategies – Cleveland Clinic Journal of Medicine

 


Systematic Review | Post-mastectomy RT likely lowers recurrence and improves survival in early breast cancer with 1-3 positive nodes

25 Jul, 2023 | 13:34h | UTC

Post‐mastectomy radiotherapy for women with early breast cancer and one to three positive lymph nodes – Cochrane Library

Summary: Is X-ray treatment (radiotherapy) after removal of breast tissue (mastectomy) better than no X-ray treatment in women diagnosed with breast cancer that has spread to one to three armpit lymph nodes? – Cochrane Library

 


RCT | Total breast reconstruction with autologous fat transfer using an expansion device vs implants in patients with breast cancer

28 Jun, 2023 | 13:12h | UTC

Effect of Total Breast Reconstruction With Autologous Fat Transfer Using an Expansion Device vs Implants on Quality of Life Among Patients With Breast Cancer: A Randomized Clinical Trial – JAMA Surgery (link to abstract – $ for full-text)

See also: Visual Abstract

Author Interview: Effect of Breast Reconstruction With Autologous Fat Transfer vs Implants on Quality of Life – JAMA

 


M-A | Effectiveness of physical therapy in axillary web syndrome after breast cancer

27 Jun, 2023 | 13:28h | UTC

Effectiveness of physical therapy in axillary web syndrome after breast cancer: a systematic review and meta-analysis – Supportive Care in Cancer

 


Review | Treatment options in HER2-low breast cancer and proposed treatment sequencing algorithm

26 Jun, 2023 | 00:27h | UTC

A review of treatment options in HER2-low breast cancer and proposed treatment sequencing algorithm – Cancer

 


Cohort Study | Steady reduction in breast cancer mortality from 1993-2015 in England

22 Jun, 2023 | 14:58h | UTC

Breast cancer mortality in 500 000 women with early invasive breast cancer in England, 1993-2015: population based observational cohort study – The BMJ

Invited Commentary: Risk of breast cancer death after a diagnosis of early invasive breast cancer – The BMJ

News Release: Women diagnosed with early breast cancer today are much less likely to die from the disease than 20 years ago – University of Oxford

 

Commentary on Twitter

 


Updated Guidance | Diagnosis and treatment of Early and locally advanced breast cancer

22 Jun, 2023 | 14:52h | UTC

Early and locally advanced breast cancer: diagnosis and management – National Institute for Health and Care Excellence

 


RCT | Increased detection of metastases via PET-CT alters treatment path in locally advanced breast cancer

16 Jun, 2023 | 14:02h | UTC

Impact of 18F-Labeled Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography Versus Conventional Staging in Patients With Locally Advanced Breast Cancer – Journal of Clinical Oncology (link to abstract – $ for full-text)

 


RCT | Dose-escalated simultaneous integrated boost radiotherapy in early breast cancer

15 Jun, 2023 | 15:04h | UTC

Dose-escalated simultaneous integrated boost radiotherapy in early breast cancer (IMPORT HIGH): a multicentre, phase 3, non-inferiority, open-label, randomised controlled trial – The Lancet

 


ASCO Guideline Update | Human epidermal growth factor receptor 2 testing in breast cancer

14 Jun, 2023 | 14:15h | UTC

Human Epidermal Growth Factor Receptor 2 Testing in Breast Cancer: American Society of Clinical Oncology–College of American Pathologists Guideline Update – Journal of Clinical Oncology

Commentary: ASCO-CAP Guideline Update Confirms Previous Recommendations for HER2 Testing in Breast Cancer – ASCO Daily News

 


RCT | Capivasertib–fulvestrant improves PFS vs. fulvestrant alone in HR+ advanced breast cancer

13 Jun, 2023 | 13:54h | UTC

Capivasertib in Hormone Receptor–Positive Advanced Breast Cancer – New England Journal of Medicine (link to abstract – $ for full-text)

Video: Capivasertib in Advanced Breast Cancer | NEJM

Commentary: Capivasertib-fulvestrant therapy increases PFS in HR-positive breast cancer – MedicalXpress

 

Commentary on Twitter

 


RCT | Adding dalpiciclib to standard letrozole or anastrozole treatment outperforms placebo in HR+, HER2- advanced breast cancer

7 Jun, 2023 | 13:44h | UTC

Dalpiciclib plus letrozole or anastrozole versus placebo plus letrozole or anastrozole as first-line treatment in patients with hormone receptor-positive, HER2-negative advanced breast cancer (DAWNA-2): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial – The Lancet Oncology (link to abstract – $ for full-text)

Commentary: Dalpiciclib Combo Improves PFS Vs Placebo in HER2– Advanced Breast Cancer – Cancer Network

 


Review | Advances in systemic therapies for triple negative breast cancer

5 Jun, 2023 | 13:36h | UTC

Advances in systemic therapies for triple negative breast cancer – The BMJ

 


USPSTF Draft Statement recommends biennial screening mammography for women ages 40 to 74 years

22 May, 2023 | 13:56h | UTC

Breast Cancer: Screening – U.S. Preventive Services Task Force

Critical perspectives on the statement:

Earlier screening for breast cancer: Benefits and harms – Lown Institute

Video: Mammography – Does it save lives? | The USPSTF is incorrect | I review ALL the data – By Dr. Vinay Prasad

Why more mammograms aren’t the solution to breast cancer – Vox

 


ASCO Guideline Update | ESR1 mutation testing for HR+/HER2- metastatic breast cancer therapy

22 May, 2023 | 13:27h | UTC

Testing for ESR1 Mutations to Guide Therapy for Hormone Receptor–Positive, Human Epidermal Growth Factor Receptor 2–Negative Metastatic Breast Cancer: ASCO Guideline Rapid Recommendation Update – Journal of Clinical Oncology

Commentary: Guideline Update Provides New Testing and Treatment Recommendations for Patients With ER-Positive, HER2-Negative Metastatic Breast Cancer With ESR1 Mutations – ASCO Daily News

 


Cohort Study | Following lifestyle recommendations linked to lower recurrence in high-risk breast cancer

15 May, 2023 | 12:48h | UTC

Adherence to Cancer Prevention Lifestyle Recommendations Before, During, and 2 Years After Treatment for High-risk Breast Cancer – JAMA Network Open

Commentary: Adherence to healthy lifestyle found to cut breast cancer recurrence, mortality – HealthDay

 

Commentary on Twitter

 


Uncertainties and controversies in axillary management of patients with breast cancer

11 May, 2023 | 11:53h | UTC

Uncertainties and controversies in axillary management of patients with breast cancer – Cancer Treatment Reviews

 


Single-arm study | Halting endocrine therapy for pregnancy not linked to increased breast cancer events vs. a control cohort

10 May, 2023 | 16:01h | UTC

Interrupting Endocrine Therapy to Attempt Pregnancy after Breast Cancer – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Temporary Interruption of Adjuvant Endocrine Treatment to Attempt Pregnancy Does Not Increase Short-Term Risk for Worsening Breast Cancer Outcomes – ESMO

 

Commentary on Twitter

 


New ACR breast cancer screening guidelines call for earlier and more-intensive screening for high-risk women

9 May, 2023 | 14:50h | UTC

News Release: New ACR Breast Cancer Screening Guidelines call for earlier and more-intensive screening for high-risk women – American College of Radiology

Guideline: Breast Cancer Screening for Women at Higher-than-Average Risk: Updated Recommendations from the ACR

 


Effects of intraoperative fluorescence guidance for breast cancer lumpectomy surgery

9 May, 2023 | 14:48h | UTC

Intraoperative Fluorescence Guidance for Breast Cancer Lumpectomy Surgery – NEJM Evidence

News Release: Study finds fluorescent guide can help detect tumor left behind after breast cancer surgery – Mass General Brigham

 


RCT | Postoperative adjuvant anastrozole for 10 or 5 years in patients with hormone receptor–positive breast cancer

9 May, 2023 | 14:32h | UTC

Postoperative Adjuvant Anastrozole for 10 or 5 Years in Patients With Hormone Receptor–Positive Breast Cancer: AERAS, a Randomized Multicenter Open-Label Phase III Trial – Journal of Clinical Oncology (link to abstract – $ for full-text)

 


M-A | Quality of life after risk-reducing surgery for breast and ovarian cancer prevention

9 May, 2023 | 14:21h | UTC

Quality of life after risk-reducing surgery for breast and ovarian cancer prevention: a systematic review and meta-analysis – American Journal of Obstetrics and Gynecology

 


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