Allergy & Immunology
M-A | Metabolic adverse events associated with systemic corticosteroid therapy
24 Jan, 2023 | 14:10h | UTC
RCT | Lebrikizumab in combination with topical corticosteroids in adolescents and adults with moderate-to-severe atopic dermatitis
15 Jan, 2023 | 20:07h | UTC
Commentary on Twitter
Does blocking the IL-13 cytokine w/ lebrikizumab combined w/ topical therapy provide clinical benefit in atopic eczema? This study reflecting real-world use patterns suggests a benefit. https://t.co/apUvYO3Jqv
— JAMA Dermatology (@JAMADerm) January 13, 2023
Phase 1-2 study | Lentiviral gene therapy for artemis-deficient SCID
12 Jan, 2023 | 12:59h | UTCLentiviral Gene Therapy for Artemis-Deficient SCID – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Infant gene therapy is a breakthrough for Artemis-SCID patients – University of California – San Francisco
Commentary on Twitter
Severe combined immunodeficiency caused by mutations in the gene encoding a DNA-repair enzyme called Artemis is difficult to treat. This study involving 10 patients supports a gene-therapy approach. https://t.co/SCpZjOQtMW pic.twitter.com/VRYOje6UPV
— NEJM (@NEJM) December 22, 2022
SR | Skin care interventions in infants for preventing eczema and food allergy.
12 Dec, 2022 | 12:23h | UTCSkin care interventions in infants for preventing eczema and food allergy – Cochrane Library
Summary: Skin care interventions for preventing eczema and food allergy – Cochrane Library
Commentary on Twitter
Read our newest review on skin care interventions in infants for preventing eczema and food allergy! https://t.co/o8HtBXRVM5 pic.twitter.com/BPzsjJZvTf
— Cochrane Skin (@CochraneSkin) November 15, 2022
M-A | Allergen immunotherapy for atopic dermatitis.
9 Dec, 2022 | 13:24h | UTC
Improving antimicrobial stewardship with penicillin allergy testing: a review of current practices and unmet needs.
27 Nov, 2022 | 22:25h | UTCRelated:
M-A: Most patients with allergy to Penicillin can be given Cefazolin
Podcast: A Clinical Pharmacologist’s Perspective on Penicillin Allergy
Study: Development and Validation of a Penicillin Allergy Clinical Decision Rule
NICE: Double Check Patients with ‘Penicillin Allergy’ to Avoid Increased MRSA Risk
SR | Interventions for the long‐term prevention of hereditary angioedema attacks.
27 Nov, 2022 | 22:12h | UTCInterventions for the long‐term prevention of hereditary angioedema attacks – Cochrane Library
Summary: Drug treatments for the prevention of attacks of hereditary angioedema – Cochrane Library
Commentary on Twitter
New #CochraneEvidence – Interventions for the long‐term prevention of #HereditaryAngioedema attacks #HAE @CochraneUK @CochraneLibrary @US_HAEA @UCSDHealth @HAEDAY @VSGBI @ChariteBerlin https://t.co/jYYjmG1eGH pic.twitter.com/2z522Bw5iZ
— CochraneVasc (@CochraneVasc) November 7, 2022
RCT | Efficacy and safety of Remibrutinib, a novel BTK inhibitor, for chronic spontaneous urticaria.
23 Nov, 2022 | 13:37h | UTC
M-A | Long-term outcomes of turbinate surgery in patients with allergic rhinitis.
18 Nov, 2022 | 13:09h | UTCLong-term Outcomes of Turbinate Surgery in Patients With Allergic Rhinitis: A Systematic Review and Meta-analysis – JAMA Otolaryngology—Head & Neck Surgery (free for a limited period)
SR | Immunostimulants vs. placebo for preventing exacerbations in adults with chronic bronchitis or COPD.
16 Nov, 2022 | 13:34h | UTC
RCT | Effects of combination treatment with tezepelumab and allergen immunotherapy on nasal responses to allergen.
8 Nov, 2022 | 12:06h | UTCEffects of combination treatment with tezepelumab and allergen immunotherapy on nasal responses to allergen: a randomized controlled trial – Journal of Allergy and Clinical Immunology (link to abstract – $ for full-text)
News Release: Monoclonal antibody improves cat allergen immunotherapy – National Institutes of Health
Safety of Upadacitinib in moderate-to-severe atopic dermatitis: an integrated analysis of phase 3 studies.
19 Oct, 2022 | 14:14h | UTC
WAO/EAACI guideline for the management of hereditary angioedema.
4 Oct, 2022 | 14:34h | UTC
RCT | Dupilumab in children aged 6 months to younger than 6 years with uncontrolled atopic dermatitis.
20 Sep, 2022 | 13:20h | UTCCommentary: Dupilumab Eases Atopic Dermatitis in Children Younger Than 6 Years – HealthDay
Guideline Summary | Management of patients with suspected or confirmed antibiotic allergy.
8 Sep, 2022 | 14:42h | UTCRelated:
M-A: Most patients with allergy to Penicillin can be given Cefazolin
Podcast: A Clinical Pharmacologist’s Perspective on Penicillin Allergy
Study: Development and Validation of a Penicillin Allergy Clinical Decision Rule
NICE: Double Check Patients with ‘Penicillin Allergy’ to Avoid Increased MRSA Risk
European guideline (EuroGuiDerm) on atopic eczema – Part II | Non-systemic treatments and treatment recommendations for special AE patient populations.
5 Sep, 2022 | 14:32h | UTC
Guideline | Management of kidney transplant patients with HLA antibodies.
31 Aug, 2022 | 11:47h | UTC
Clinical practice guidelines for the management of atopic dermatitis.
24 Aug, 2022 | 14:13h | UTC
European guideline on atopic eczema – Part I: systemic therapy.
19 Aug, 2022 | 16:14h | UTC
Review | Plasma exchange in the intensive care unit.
15 Aug, 2022 | 12:19h | UTCPlasma exchange in the intensive care unit: a narrative review – Intensive Care Medicine
Commentary on Twitter
Therapeutic plasma exchange in #ICU
🟨 indications for urgent TPE
🟨 mechanisms, kinetics and therapeutic goals
🟨 diagnostic workup & monitoring
🟨 technical aspects
🟨 clinical response & complications
🟨 unanswered questions & research agenda#FOAMcc
📎 https://t.co/CojkcA81Dy pic.twitter.com/MsAdjgJhNL— Intensive Care Medicine (@yourICM) August 13, 2022
M-A | Interventions to reduce infections in patients with hematological malignancies.
15 Aug, 2022 | 11:51h | UTCCommentary: Prophylactic Immunoglobulin, Vaccinations May Reduce Infections in Hematologic Malignancies – AJMC
Consensus Statement | Pharmacological management of allergic rhinitis.
11 Aug, 2022 | 12:10h | UTCRelated:
Guideline | Management of immunoglobulin replacement therapy.
5 Aug, 2022 | 14:35h | UTC
M-A | Treating eosinophilic esophagitis with budesonide.
27 Jul, 2022 | 12:06h | UTC
RCT | Efficacy and safety of Abrocitinib vs. Dupilumab in adults with moderate-to-severe atopic dermatitis.
25 Jul, 2022 | 12:44h | UTCEfficacy and safety of abrocitinib versus dupilumab in adults with moderate-to-severe atopic dermatitis: a randomised, double-blind, multicentre phase 3 trial – The Lancet (link to abstract – $ for full-text)
Related: Abrocitinib versus Placebo or Dupilumab for Atopic Dermatitis – New England Journal of Medicine