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Allergy & Immunology

SARS-CoV-2 Infection Protects Against Rechallenge in Rhesus Macaques

21 May, 2020 | 09:27h | UTC

SARS-CoV-2 infection protects against rechallenge in rhesus macaques – Science

Related Study: DNA vaccine protection against SARS-CoV-2 in rhesus macaques – Science

Commentaries: Infection With SARS-CoV-2 Protects Against Re-infection – At Least in Rhesus Macaques – Technology Networks AND Prototype Vaccine Protects Monkeys From Coronavirus – The New York Times

 


Serology for SARS-CoV-2: Apprehensions, Opportunities, and the Path Forward

20 May, 2020 | 09:53h | UTC

Serology for SARS-CoV-2: Apprehensions, opportunities, and the path forward – Science Immunology

 


Case Series: Hyperinflammatory Shock in Children During COVID-19 Pandemic

7 May, 2020 | 09:21h | UTC

Hyperinflammatory shock in children during COVID-19 pandemic – The Lancet

Commentaries: Researchers report “unprecedented cluster” of inflammatory problems in children amid pandemic – CNN AND Expert reaction to report on 8 children with hyperinflammatory shock during the COVID-19 pandemic – Science Media Centre AND Mysterious inflammatory syndrome in children potentially linked to COVID-19 reported in Montreal – National Post AND A New Coronavirus Threat to Children – The New York Times AND What to Know About Kawasaki Disease, the Pediatric Inflammatory Condition Possibly Linked to COVID-19 – TIME AND Kawasaki Disease—The Latest Weird Illness From Coronavirus – Forbes

 


Study: Development and Validation of a Penicillin Allergy Clinical Decision Rule

17 Mar, 2020 | 08:37h | UTC

Development and Validation of a Penicillin Allergy Clinical Decision Rule – JAMA Internal Medicine (free for a limited period)

 


FDA Safety Alert: Montelukast May Cause Serious Mental Health Side Effects

6 Mar, 2020 | 10:22h | UTC

FDA requires Boxed Warning about serious mental health side effects for asthma and allergy drug montelukast (Singulair); advises restricting use for allergic rhinitis – U.S. Food & Drug Administration (free)

Commentary: Montelukast to Get Boxed Warning – NEJM Journal Watch (free)

 


[Abstract Only] Randomized Trial: Metformin May Reduce Metabolic Complications and Inflammation in Patients on Systemic Glucocorticoid Therapy

27 Feb, 2020 | 08:34h | UTC

Metformin to reduce metabolic complications and inflammation in patients on systemic glucocorticoid therapy: a randomised, double-blind, placebo-controlled, proof-of-concept, phase 2 trial – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)

Commentaries: Metformin could mitigate glucocorticoid-related complications – Medicine Matters (free) AND Metabolic effects of glucocorticoids reversed with metformin – Healio (free registration required) AND Diabetes Drug May Benefit Long-Term Steroid Users – MedPage Today (free registration required)

 


Cohort Study: Frequent Use of Household Cleaning Products in Early Life Linked to Increased Risk for Childhood Wheeze and Asthma at Age 3 Years

23 Feb, 2020 | 21:44h | UTC

Association of use of cleaning products with respiratory health in a Canadian birth cohort – Canadian Medical Association Journal (free)

Commentaries: Cleaning products and asthma risk: a potentially important public health concern – Canadian Medical Association Journal (free) AND Exposure to cleaning products linked to asthma and wheezing in children – Health Europa (free) AND Cleaning Products May Raise Risk of Wheezing and Asthma in Young Children – MedicalResearch.com (free)

 


Clinical Updates: Management of Acute and Chronic Asthma in Adults in 2020

14 Feb, 2020 | 02:06h | UTC

Management of Acute Asthma in Adults in 2020 – JAMA (free for a limited period)

Related Article: Outpatient Management of Chronic Asthma in 2020 – JAMA (free for a limited period)

Editorial: New Therapeutic Strategies for Asthma – JAMA (free for a limited period)

 


Clinical Management of Seafood Allergy

21 Jan, 2020 | 01:11h | UTC

Clinical Management of Seafood Allergy – The Journal of Allergy and Clinical Immunology: In Practice (free)

 


Guidelines for Diagnosis, Management, Treatment and Prevention of DRESS syndrome

17 Jan, 2020 | 09:43h | UTC

Spanish Guidelines for Diagnosis, Management, Treatment and Prevention of DRESS syndrome – Journal of Investigational Allergology and Clinical Immunology (free PDF)

 


Atrial Fibrillation: Current Evidence and Management Strategies During the Perioperative Period

9 Jan, 2020 | 23:36h | UTC

Atrial Fibrillation: Current Evidence and Management Strategies During the Perioperative Period – Anesthesia & Analgesia (free)

 


ASH Guideline: Immune Thrombocytopenia

5 Dec, 2019 | 11:19h | UTC

American Society of Hematology 2019 guidelines for immune thrombocytopenia – Blood Advances (free)

Related: Consensus Report: Investigation and Management of Primary Immune Thrombocytopenia (guidelines and reviews on the subject)

 


Study: Early Introduction of Allergenic Foods Can Prevent Food Allergies in High Risk Infants

5 Dec, 2019 | 10:28h | UTC

Efficacy of the Enquiring About Tolerance (EAT) study among infants at high risk of developing food allergy – The Journal of Allergy and Clinical Immunology (free)

See also: Factors influencing adherence in a trial of early introduction of allergenic food – The Journal of Allergy and Clinical Immunology (free) AND Challenges experienced with early introduction and sustained consumption of allergenic foods in the Enquiring About Tolerance (EAT) study: A qualitative analysis – The Journal of Allergy and Clinical Immunology (free)

Original EAT Study: Randomized Trial of Introduction of Allergenic Foods in Breast-Fed Infants – New England Journal of Medicine (free)

Commentaries: Introducing peanuts and eggs early can prevent food allergies in high risk infants – King’s College London (free) AND Expert reaction to three studies looking at early introduction of allergenic foods to infants – Science Media Centre (free)

Related Guidelines: AAP Updated Recommendations for Dietary Interventions to Prevent Atopic Disease (free guidance and commentaries) AND Timing of introduction of allergenic solids for infants at high risk – Canadian Paediatric Society (free)

 


#KidneyWk – [Abstract Only] Randomized Trial: New Drug May Reduce Itch Intensity in Hemodialysis Patients

10 Nov, 2019 | 14:34h | UTC

A Phase 3 Trial of Difelikefalin in Hemodialysis Patients with Pruritus – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Novel Drug Eases Uremic Pruritus – Renal & Urology News (free)

#KidneyWk – Just presented at the American Society of Nephrology Kidney Week 2019

 


Review: Eosinophilic Gastrointestinal Diseases in Childhood

22 Oct, 2019 | 07:18h | UTC

Eosinophilic Gastrointestinal Diseases in Childhood – Annals of Nutrition & Metabolism (free)

 


CSACI Position Statement: Newer Generation H1-Antihistamines are Safer than First-generation H1-Antihistamines

16 Oct, 2019 | 10:32h | UTC

CSACI position statement: Newer generation H1-antihistamines are safer than first-generation H1-antihistamines and should be the first-line antihistamines for the treatment of allergic rhinitis and urticaria – Allergy, Asthma & Clinical Immunology (free)

 


[Abstract Only] Randomized Trial: Monoclonal Anti-IgE Antibody for Chronic Spontaneous Urticaria

7 Oct, 2019 | 00:47h | UTC

Ligelizumab for Chronic Spontaneous Urticaria – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Ligelizumab safely, effectively treats hives – MedicalXpress (free) AND Ligelizumab May Improve Response in Chronic Urticaria – Medscape (free registration required)

 


[Abstract Only] Randomized Trial: Monoclonal Antibody for Patients with Severe Chronic Rhinosinusitis with Nasal Polyps

2 Oct, 2019 | 22:17h | UTC

Efficacy and safety of dupilumab in patients with severe chronic rhinosinusitis with nasal polyps (LIBERTY NP SINUS-24 and LIBERTY NP SINUS-52): results from two multicentre, randomised, double-blind, placebo-controlled, parallel-group phase 3 trials – The Lancet (link to abstract – $ for full-text)

 

Related Commentary on Twitter

 


Short Review: Food Allergy Prevention with Early Food Introduction

16 Sep, 2019 | 02:16h | UTC

Food allergy prevention with early food introduction: New recommendations on introducing allergenic solids – Canadian Family Physician (free)

Original Guideline: Timing of introduction of allergenic solids for infants at high risk – Canadian Paediatric Society (free)

See also: AAP Updated Recommendations for Dietary Interventions to Prevent Atopic Disease (free guideline and commentary)

 


Evaluation and Management of Angioedema in the Emergency Department

15 Sep, 2019 | 23:43h | UTC

Evaluation and Management of Angioedema in the Emergency Department – West Journal of Emergency Medicine (free)

Source: Medscape

 


[Abstract Only] Study: Few People with Peanut Allergy Tolerate Peanut After Stopping Oral Immunotherapy

15 Sep, 2019 | 23:32h | UTC

Few people with peanut allergy tolerate peanut after stopping oral immunotherapy – NIH News Releases (free)

Original Study: Sustained outcomes in oral immunotherapy for peanut allergy (POISED study): a large, randomised, double-blind, placebo-controlled, phase 2 study – The Lancet (link to abstract – $ for full-text)

Related: Meta-Analysis: Oral Immunotherapy for Peanut Allergy INCREASES Allergic and Anaphylactic Reactions (link to abstract and commentaries)

 


Guideline: Management of Chronic Urticaria in Children

18 Aug, 2019 | 21:34h | UTC

Management of chronic urticaria in children: a clinical guideline – Italian Journal of Pediatrics (free)

Related Guidelines: BSACI guideline for the management of chronic urticaria and angioedema (free) AND The EAACI/GA²LEN/EDF/WAO guideline for the definition, classification, diagnosis and management of urticaria (free) AND The diagnosis and management of acute and chronic urticaria: 2014 update – American Academy of Allergy, Asthma & Immunology (AAAAI) (free) AND ASCIA Chronic Spontaneous Urticaria (CSU) Position Paper and Treatment Guidelines (free)

 


Study: High Gluten Intake During Childhood May Increase the Risk of Celiac Disease in Genetically Predisposed Children

15 Aug, 2019 | 08:12h | UTC

Association of Gluten Intake During the First 5 Years of Life With Incidence of Celiac Disease Autoimmunity and Celiac Disease Among Children at Increased Risk – JAMA (free for a limited period)

Editorial: Gluten and Celiac Disease Risk: Is It Just a Matter of Quantity? (free for a limited period)

Commentaries: Association between coeliac disease risk and gluten intake confirmed – Lund University (free) High Gluten Diet Adds to Risk of Celiac Disease In Genetically Predisposed Children – MedicalResearch.com (free) AND Eating more gluten early in life is tied to children’s higher risk of celiac disease, a study says – CNN (free)

 


Expert Consensus: Management of Hypersensitivity Reactions to Intravenous Iron in Adults

2 Aug, 2019 | 00:05h | UTC

Canadian expert consensus: management of hypersensitivity reactions to intravenous iron in adults – Vox Sanguinis (free)

 


Observational Study Suggests Use of Acid-Suppressing Drugs May Increase the Risk of Allergies

1 Aug, 2019 | 07:37h | UTC

Country-wide medical records infer increased allergy risk of gastric acid inhibition – Nature Communications (free)

Commentaries: Stomach-protecting medicines can trigger allergies – Medical University of Vienna (free) AND Acid-Suppressing Drugs Tied to Later Use of Anti-Allergy Drugs – NEJM Journal Watch (free) AND Your heartburn drugs may be giving you allergies, study suggests – CNN (free)