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Allergy & Immunology

Developing a SARS-CoV-2 Vaccine at Warp Speed

7 Jul, 2020 | 08:59h | UTC

Developing a SARS-CoV-2 Vaccine at Warp Speed – JAMA

Related Video: Coronavirus Vaccine Development – JAMA


Study Addresses Clinical Validity and Utility of Serum Antibodies to SARS-CoV-2

7 Jul, 2020 | 08:55h | UTC

Clinical Validity of Serum Antibodies to SARS-CoV-2: A Case–Control Study – Annals of Internal Medicine


Podcast: A Clinical Pharmacologist’s Perspective on Penicillin Allergy

7 Jul, 2020 | 08:43h | UTC

A Clinical Pharmacologist’s Perspective on Penicillin Allergy – JAMA


Editorial: Is a “Cytokine Storm” Relevant to COVID-19?

1 Jul, 2020 | 07:59h | UTC

Is a “Cytokine Storm” Relevant to COVID-19? – JAMA Internal Medicine


Related Commentary on Twitter


[Preprint] Immunity to COVID-19 is Probably Higher than Tests Have Shown

30 Jun, 2020 | 08:04h | UTC

Immunity to COVID-19 is probably higher than tests have shown – Karolinska Institutet

Original Study: Robust T cell immunity in convalescent individuals with asymptomatic or mild COVID-19 – bioRxiv


Opinion – Coronavirus: Could it be Burning out After 20% of a Population is Infected?

30 Jun, 2020 | 08:00h | UTC

Coronavirus: could it be burning out after 20% of a population is infected? – The Conversation


Studies: Childhood Multisystem Inflammatory Syndrome — A New Challenge in the Pandemic

30 Jun, 2020 | 07:57h | UTC

Study 1: Multisystem Inflammatory Syndrome in U.S. Children and Adolescents – New England Journal of Medicine

Study 2: Multisystem Inflammatory Syndrome in Children in New York State – New England Journal of Medicine

Editorial: Childhood Multisystem Inflammatory Syndrome — A New Challenge in the Pandemic – New England Journal of Medicine

Commentaries: Worrisome details noted in kids with COVID inflammatory syndrome – CIDRAP AND Researchers report nearly 300 cases of inflammatory syndrome tied to Covid-19 in kids – STAT


Systematic Review: Antibody Tests for Identification of Current and Past Infection with SARS‐CoV‐2

26 Jun, 2020 | 09:19h | UTC

Antibody tests for identification of current and past infection with SARS‐CoV‐2 – Cochrane Library

News Release: New Cochrane review assesses how accurate antibody tests are for detecting COVID-19 – Cochrane Library

Commentaries: New Cochrane review assesses how accurate antibody tests are for detecting COVID-19 – Wiley AND Expert reaction to Cochrane Review of antibody tests for SARS-CoV-2 – Science Media Centre AND Covid-19: Timing is critical for antibody tests, finds Cochrane review – The BMJ


Covid-19 Antibody Tests: A Briefing

26 Jun, 2020 | 09:17h | UTC

Covid-19 antibody tests: a briefing – The BMJ

Commentary: Coronavirus: Antibody test lacks ‘proper assessment’ – BBC


Perspective: “I’m a Viral Immunologist. Here’s What Antibody Tests for Covid-19 Tell Us”

26 Jun, 2020 | 09:15h | UTC

I’m a viral immunologist. Here’s what antibody tests for Covid-19 tell us – The Guardian


[Preprint] Intrafamilial Exposure to SARS-CoV-2 Induces Cellular Immune Response without Seroconversion

25 Jun, 2020 | 08:21h | UTC

Intrafamilial Exposure to SARS-CoV-2 Induces Cellular Immune Response without Seroconversion – medRxiv

Commentary: Exposure to SARS-CoV-2 can induce virus-specific T cell responses without seroconversion – News Medical


A Compendium Answering 150 Questions on COVID‐19 and SARS‐CoV‐2

23 Jun, 2020 | 08:38h | UTC

A compendium answering 150 questions on COVID‐19 and SARS‐CoV‐2 – Allergy


Study: Coronavirus Antibodies Can Disappear After a Few Months

21 Jun, 2020 | 23:46h | UTC

Clinical and immunological assessment of asymptomatic SARS-CoV-2 infections – Nature Medicine

Commentaries: Chinese study: Antibodies in COVID-19 patients fade quickly – CIDRAP AND Coronavirus antibodies may disappear 2 to 3 months after people recover, a new study found – Business Insider AND New insights can change everything we know about coronavirus antibodies – BGR – News Beezer AND Expert reaction to study looking at the immune response of 37 asymptomatic people with confirmed SARS-CoV-2 infection – Science Media Centre AND You May Have Antibodies After Coronavirus Infection. But Not for Long – The New York Times


The Science Behind the Search for a Covid-19 Vaccine

17 Jun, 2020 | 02:37h | UTC

The Science Behind the Search for a Covid-19 Vaccine – University of Melbourne


COVID-19 Vaccine Development Pipeline Gears Up

5 Jun, 2020 | 04:59h | UTC

COVID-19 vaccine development pipeline gears up – The Lancet


Perspective: Why a Vaccine May Not be Enough to End the Pandemic

4 Jun, 2020 | 04:54h | UTC

Why a vaccine may not be enough to end the pandemic – Vox


[Abstract Only] Analysis: Milk Allergy Guidelines May Cause Overdiagnosis in Babies and Children

3 Jun, 2020 | 03:33h | UTC

Milk Allergy Guidelines may Cause Overdiagnosis in Babies and Children – Imperial College London

Original Study: Assessment of Evidence About Common Infant Symptoms and Cow’s Milk Allergy – JAMA Pediatrics (link to abstract – $ for full-text)


Cohort Study: Fexofenadine use During Pregnancy Does Not Appear to Be Associated with Increased Risk of Adverse Fetal Outcomes

3 Jun, 2020 | 03:31h | UTC

Association Between Fexofenadine Use During Pregnancy and Fetal Outcomes – JAMA Pediatrics (free for a limited period)


SARS-CoV-2 Infection Protects Against Rechallenge in Rhesus Macaques

21 May, 2020 | 09:27h | UTC

SARS-CoV-2 infection protects against rechallenge in rhesus macaques – Science

Related Study: DNA vaccine protection against SARS-CoV-2 in rhesus macaques – Science

Commentaries: Infection With SARS-CoV-2 Protects Against Re-infection – At Least in Rhesus Macaques – Technology Networks AND Prototype Vaccine Protects Monkeys From Coronavirus – The New York Times


Serology for SARS-CoV-2: Apprehensions, Opportunities, and the Path Forward

20 May, 2020 | 09:53h | UTC

Serology for SARS-CoV-2: Apprehensions, opportunities, and the path forward – Science Immunology


Case Series: Hyperinflammatory Shock in Children During COVID-19 Pandemic

7 May, 2020 | 09:21h | UTC

Hyperinflammatory shock in children during COVID-19 pandemic – The Lancet

Commentaries: Researchers report “unprecedented cluster” of inflammatory problems in children amid pandemic – CNN AND Expert reaction to report on 8 children with hyperinflammatory shock during the COVID-19 pandemic – Science Media Centre AND Mysterious inflammatory syndrome in children potentially linked to COVID-19 reported in Montreal – National Post AND A New Coronavirus Threat to Children – The New York Times AND What to Know About Kawasaki Disease, the Pediatric Inflammatory Condition Possibly Linked to COVID-19 – TIME AND Kawasaki Disease—The Latest Weird Illness From Coronavirus – Forbes


Study: Development and Validation of a Penicillin Allergy Clinical Decision Rule

17 Mar, 2020 | 08:37h | UTC

Development and Validation of a Penicillin Allergy Clinical Decision Rule – JAMA Internal Medicine (free for a limited period)


FDA Safety Alert: Montelukast May Cause Serious Mental Health Side Effects

6 Mar, 2020 | 10:22h | UTC

FDA requires Boxed Warning about serious mental health side effects for asthma and allergy drug montelukast (Singulair); advises restricting use for allergic rhinitis – U.S. Food & Drug Administration (free)

Commentary: Montelukast to Get Boxed Warning – NEJM Journal Watch (free)


[Abstract Only] Randomized Trial: Metformin May Reduce Metabolic Complications and Inflammation in Patients on Systemic Glucocorticoid Therapy

27 Feb, 2020 | 08:34h | UTC

Metformin to reduce metabolic complications and inflammation in patients on systemic glucocorticoid therapy: a randomised, double-blind, placebo-controlled, proof-of-concept, phase 2 trial – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)

Commentaries: Metformin could mitigate glucocorticoid-related complications – Medicine Matters (free) AND Metabolic effects of glucocorticoids reversed with metformin – Healio (free registration required) AND Diabetes Drug May Benefit Long-Term Steroid Users – MedPage Today (free registration required)


Cohort Study: Frequent Use of Household Cleaning Products in Early Life Linked to Increased Risk for Childhood Wheeze and Asthma at Age 3 Years

23 Feb, 2020 | 21:44h | UTC

Association of use of cleaning products with respiratory health in a Canadian birth cohort – Canadian Medical Association Journal (free)

Commentaries: Cleaning products and asthma risk: a potentially important public health concern – Canadian Medical Association Journal (free) AND Exposure to cleaning products linked to asthma and wheezing in children – Health Europa (free) AND Cleaning Products May Raise Risk of Wheezing and Asthma in Young Children – (free)


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