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Opinion: COVID-19 will continue but the end of the pandemic is near.

21 Jan, 2022 | 10:16h | UTC

COVID-19 will continue but the end of the pandemic is near – The Lancet

 

Commentary on Twitter

 


Opinion: Now that science has defanged Covid, it’s time to get on with our lives.

21 Jan, 2022 | 10:14h | UTC

Now that science has defanged Covid, it’s time to get on with our lives – The Guardian

See also: A National Strategy for the “New Normal” of Life With COVID – JAMA

 


Europe considers new COVID-19 strategy: Accepting the virus.

21 Jan, 2022 | 10:13h | UTC

Europe considers new COVID-19 strategy: Accepting the virus – Associated Press

 


RCT: Immunogenicity and reactogenicity of different vaccine boosters after a first J&J vaccine.

21 Jan, 2022 | 10:12h | UTC

Immunogenicity and Reactogenicity of Vaccine Boosters after Ad26.COV2.S Priming – New England Journal of Medicine

 

Commentary on Twitter

 


Perspective: Nervous system consequences of COVID-19.

21 Jan, 2022 | 10:10h | UTC

Nervous system consequences of COVID-19 – Science

Related:

Perspective | Post-acute neurological consequences of COVID-19: an unequal burden – “COVID-19 and its neurological consequences particularly burden marginalized communities, and so can only be effectively treated by advancing health equity”.

Review: Counting the neurological cost of COVID-19.

Infection with Covid-19 carries a much higher risk of developing neurological complications than Covid-19 vaccines.

M-A: Frequency of Neurologic Manifestations in COVID-19 – up to one-third of patients (89% hospitalized) experienced at least one neurological manifestation.

Neurological Effects of COVID-19 in Children.

Cohort study: Neurological manifestations of SARS-CoV-2 infection in hospitalized children and adolescents in the UK – “around 1 in 20 of children hospitalized with COVID-19 develop brain or nerve complications linked to the viral infection”.

International Registry: Ischemic and hemorrhagic stroke among critically ill patients with Covid-19.

Short review: Neurological complications of COVID-19.

2 new meta-analysis detail neurologic and psychiatric conditions in COVID-19.

M-A: Encephalitis as Neurological Complication of COVID‐19.

Large study finds 1 in 3 Covid-19 survivors have subsequent mental health and neurological conditionsEight out of ten people hospitalized with COVID-19 develop neurological problems – the most common self-reported symptoms included headache (37%) and anosmia or ageusia (26%).

[Preprint] Frequency of neurological manifestations in COVID-19: a systematic review and meta-analysis of 350 studies – up to one-third of COVID-19 patients analyzed in this review, 89% of whom were hospitalized, experienced at least one neurological manifestation

 

Commentary on Twitter

 


Review: Postdischarge Evaluation for Individuals Hospitalized with COVID-19.

21 Jan, 2022 | 10:08h | UTC

Postdischarge Evaluation for Individuals Hospitalized with COVID-19 – Southern Medical Journal

 


[Preprint] COVID infection severity in children under 5 years old before and after Omicron emergence in the US.

21 Jan, 2022 | 10:04h | UTC

COVID infection severity in children under 5 years old before and after Omicron emergence in the US – medRxiv

Commentary: SARS-CoV-2 Omicron infections milder in children compared to Delta – News Medical

 


WHO’s Emergencies expert group re-asserts stance against covid ‘vaccine passports’ for international travel.

21 Jan, 2022 | 10:02h | UTC

WHO’s Emergencies Expert Group Re-Asserts Stance Against COVID ‘Vaccine Passports’ for International Travel – Health Policy Watch

 


Editorial | Covid-19 vaccines and treatments: we must have raw data, now.

21 Jan, 2022 | 10:00h | UTC

Covid-19 vaccines and treatments: we must have raw data, now – The BMJ

News Release: Editors call for covid-19 vaccine and treatment data to be available for public scrutiny – The BMJ

 


Editorial | Long covid in children and adolescents – “Risk appears low, but many questions remain”.

21 Jan, 2022 | 09:58h | UTC

Long covid in children and adolescents – The BMJ

Related:

M-A: Persistent symptoms following SARS-CoV-2 infection among children and young people – “Higher study quality was associated with lower prevalence of all symptoms, except loss of smell and cognitive symptoms”.

Review: Long COVID symptoms in children rarely persist beyond three months.

Cohort study: long term follow-up showed most patients with post–COVID-19 Multisystem Inflammatory Syndrome in Children had good outcomes with no significant medium- or long-term sequelae.

Long COVID: the physical and mental health of children and non-hospitalized young people after SARS-CoV-2 infection – one in seven children may still have symptoms 15 weeks after infection.

Do kids get long COVID? And how often? A pediatrician looks at the data – Children also get Long Covid, but much less often than adults.

Illness duration and symptom profile in symptomatic school-aged children tested for SARS-CoV-2 – “Only 25 (1.8%) of 1379 children experienced symptoms for at least 56 days.”

Long-term Symptoms After SARS-CoV-2 Infection in Children and Adolescents – “This study found a low prevalence of symptoms compatible with long COVID in a randomly selected cohort of children assessed 6 months after serologic testing”.

Study shows low incidence of post-acute COVID-19 symptoms (“Long Covid”) in children after mild disease

Cohort study: Risk factors for long covid in previously hospitalized children.

M-A: More than 50 long-term effects of COVID-19.

 

Commentary on Twitter

 


ATS Guideline: Outpatient respiratory management of infants, children, and adolescents with post-prematurity respiratory disease.

21 Jan, 2022 | 09:55h | UTC

Outpatient Respiratory Management of Infants, Children, and Adolescents with Post-Prematurity Respiratory Disease: An Official American Thoracic Society Clinical Practice Guideline – American Journal of Respiratory and Critical Care Medicine

News Release: Outpatient Management of Patients with Post-Prematurity Respiratory Disease: American Thoracic Society Publishes New Clinical Practice Guideline

 


Perioperative guidelines on antiplatelet and anticoagulant agents: 2022 Update.

21 Jan, 2022 | 09:53h | UTC

Perioperative Guidelines on Antiplatelet and Anticoagulant Agents: 2022 Update – Current Anesthesiology Reports

 


RCT: Metal pins no better than traditional plaster cast for a broken wrist.

21 Jan, 2022 | 09:51h | UTC

News Release: Metal pins no better than traditional plaster cast for a broken wrist – BMJ

Original Study: Surgical fixation with K-wires versus casting in adults with fracture of distal radius: DRAFFT2 multicentre randomised clinical trial – The BMJ

Commentary: Wrist fractures: study compares casting to surgical fixation – MedicalResearch.com

 

Commentary on Twitter

 


Systematic Review: In people with Alzheimer’s disease and vascular dementia with agitation and psychosis, atypical antipsychotics probably reduce agitation slightly (moderate‐certainty evidence) but probably have a negligible effect on psychosis or risk of any adverse event.

21 Jan, 2022 | 09:50h | UTC

Antipsychotics for agitation and psychosis in people with Alzheimer’s disease and vascular dementia – Cochrane Library

Summary: Do antipsychotic medicines reduce  agitated behaviour and psychotic symptoms in people with Alzheimer’s disease and vascular dementia? – Cochrane Library

 


RCT: Lenvatinib plus pembrolizumab improve outcomes compared to chemotherapy in patients with advanced endometrial cancer.

21 Jan, 2022 | 09:46h | UTC

Lenvatinib plus Pembrolizumab for Advanced Endometrial Cancer – New England Journal of Medicine

 

Commentary on Twitter

 


Sleeping on the LEFT side seems to be associated with reduced nocturnal acid exposure compared with supine and right lateral decubitus positions.

21 Jan, 2022 | 09:45h | UTC

Associations Between Sleep Position and Nocturnal Gastroesophageal Reflux: A Study Using Concurrent Monitoring of Sleep Position and Esophageal pH and Impedance – American Journal of Gastroenterology (link to abstract – $ for full-text)

 


Review: Diagnostic evaluation of gastric motor and sensory disorders.

21 Jan, 2022 | 09:42h | UTC

Diagnostic Evaluation of Gastric Motor and Sensory Disorders – American Journal of Gastroenterology

 


Cohort Study: Among patients with resolved Hepatitis B infections and concomitant autoimmune disease, exposure to prednisone doses greater than 20 mg/day were associated with a high risk for HBV reactivation or hepatitis flare.

21 Jan, 2022 | 09:39h | UTC

Average corticosteroid dose and risk for HBV reactivation and hepatitis flare in patients with resolved hepatitis B infection – Annals of Rheumatic Disease (link to abstract – $ for full-text)

 

Commentary on Twitter

 


M-A: No difference in outcomes with Beta-lactam monotherapy vs. combination therapy for bloodstream infections or pneumonia due to P. aeruginosa.

21 Jan, 2022 | 09:37h | UTC

Beta-lactam monotherapy or combination therapy for bloodstream infections or pneumonia due to P. aeruginosa: a meta-analysis – International Journal of Antimicrobial Agents (link to abstract – $ for full-text)

 


Treatment for Brain Metastases: ASCO-SNO-ASTRO Guideline.

21 Jan, 2022 | 09:36h | UTC

Treatment for Brain Metastases: ASCO-SNO-ASTRO Guideline – Journal of Clinical Oncology

Related: EANO–ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up of patients with brain metastasis from solid tumors.

 


15th Report on Carcinogens now includes 256 listings of substances that are known or reasonably anticipated to cause cancer in humans.

21 Jan, 2022 | 09:34h | UTC

15th Report on Carcinogens – National Toxicology Program

 

Commentary on Twitter

 


M-A: In patients with acute coronary syndrome, a guided approach (i.e., platelet function or genetic testing) to P2Y12 inhibiting therapy may reduce major adverse cardiovascular events without increased risk of bleeding.

21 Jan, 2022 | 09:33h | UTC

Comparative effects of guided vs. potent P2Y12 inhibitor therapy in acute coronary syndrome: a network meta-analysis of 61 898 patients from 15 randomized trials – European Heart Journal (link to abstract – $ for full-text)

Commentary: Another Win for Guided P2Y12 Therapy in ACS: Meta-analysis – TCTMD

 

Commentary on Twitter

 


The validity of progression-free survival 2 as a surrogate trial end point for overall survival.

21 Jan, 2022 | 09:31h | UTC

The validity of progression-free survival 2 as a surrogate trial end point for overall survival – Cancer (link to abstract – $ for full-text)

 


Is precision public health the future — or a contradiction?

21 Jan, 2022 | 09:31h | UTC

Is precision public health the future — or a contradiction? – Nature

 


M-A: In comatose survivors of cardiac arrest, targeted hypothermia is not associated with improved survival or better neurological outcomes vs. targeted normothermia.

21 Jan, 2022 | 09:29h | UTC

Targeted Hypothermia Versus Targeted Normothermia In Survivors of Cardiac Arrest: A Systematic Review and Meta-Analysis of Randomized Trials – American Journal of Medicine

Related:

RCT: In comatose survivors of out-of-hospital cardiac arrest, there was no difference in mortality and neurologic outcomes with mild (target temperature of 34 °C) vs. moderate therapeutic hypothermia (target temperature of 31 °C).

M-A: Targeted temperature management following out-of-hospital cardiac arrest – “Routine use of moderate or deep hypothermia in comatose survivors of OHCA may potentially be associated with more harm than benefit”.

RCT: In patients with coma after out-of-hospital cardiac arrest, targeted hypothermia did not improve outcomes.

 


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