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Randomized trial: No benefit from discontinuing ACE Inhibitors and ARBs in patients admitted with COVID-19

20 Jan, 2021 | 01:55h | UTC

Effect of Discontinuing vs Continuing Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers on Days Alive and Out of the Hospital in Patients Admitted With COVID-19: A Randomized Clinical Trial – JAMA

Commentary: Discontinuing vs. Continuing ACEIs, ARBs in Patients Admitted With COVID-19 – American College of Cardiology

Related study (study and commentary): Randomized trial: Renin–angiotensin system inhibitors can be safely continued in patients admitted to hospital with COVID-19

 


Study: Crowded ICUs linked to increased mortality from COVID-19

20 Jan, 2021 | 01:53h | UTC

Association of Intensive Care Unit Patient Load and Demand With Mortality Rates in US Department of Veterans Affairs Hospitals During the COVID-19 Pandemic – JAMA Network Open

Commentaries: Intensive Care Unit Strain and Mortality Risk Among Critically Ill Patients With COVID-19—There Is No “Me” in COVID – JAMA Network Open AND Crowded ICUs tied to higher risk of COVID-19 death – CIDRAP

 


What we know about Covid-19 reinfection so far

20 Jan, 2021 | 01:52h | UTC

What we know about covid-19 reinfection so far – The BMJ

 

Commentary on Twitter

 


SARS-CoV-2 vaccines: Much accomplished, much to learn

20 Jan, 2021 | 01:51h | UTC

SARS-CoV-2 Vaccines: Much Accomplished, Much to Learn – Annals of Internal Medicine

 

Commentary on Twitter

 


Study: Household transmission of SARS-CoV-2 and risk factors for susceptibility and infectivity

20 Jan, 2021 | 01:49h | UTC

Household transmission of SARS-CoV-2 and risk factors for susceptibility and infectivity in Wuhan: a retrospective observational study – The Lancet Infectious Diseases

Related Report: SARS-CoV-2 setting-specific transmission rates. Households showed the highest transmission rates (21.1%). Asymptomatic infections do occur but much less efficiently than symptomatic infection

 

Commentary on Twitter

 


Study: Immune system ‘remembers’ coronavirus for at least 6 months

20 Jan, 2021 | 01:44h | UTC

Immune system ‘remembers’ coronavirus for at least 6 months: study – MedicalXpress

Original study: Evolution of antibody immunity to SARS-CoV-2 – Nature

 

Commentary on Twitter

 


How effective is a single vaccine dose against Covid-19?

20 Jan, 2021 | 01:42h | UTC

How effective is a single vaccine dose against Covid-19? – BBC

 


What we now know — and don’t know — about the coronavirus variants

20 Jan, 2021 | 01:41h | UTC

What we now know — and don’t know — about the coronavirus variants – STAT

Related: Covid-19: What new variants are emerging and how are they being investigated? – The BMJ

 


Perspective: Covid-19 vaccine guidance for those who are lactating is based on faulty assumptions, experts say

20 Jan, 2021 | 01:40h | UTC

Covid-19 vaccine guidance for those who are lactating is based on faulty assumptions, experts say – STAT

 


Systematic review on prophylaxis for COVID-19: Hydroxychloroquine does not work, little evidence regarding other drugs

20 Jan, 2021 | 01:38h | UTC

Prophylaxis for COVID-19: a systematic review – Clinical Microbiology and Infection

 


Randomized trial: Endovascular treatment alone noninferior to intravenous alteplase plus endovascular treatment on functional independence in patients with acute ischemic stroke

20 Jan, 2021 | 01:35h | UTC

Effect of Endovascular Treatment Alone vs Intravenous Alteplase Plus Endovascular Treatment on Functional Independence in Patients With Acute Ischemic Stroke: The DEVT Randomized Clinical Trial – JAMA (free for a limited period)

Related study: Effect of Mechanical Thrombectomy Without vs With Intravenous Thrombolysis on Functional Outcome Among Patients With Acute Ischemic Stroke: The SKIP Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Intravenous Thrombolysis Before Endovascular Thrombectomy for Acute Ischemic Stroke – JAMA (free for a limited period)

Video: Thrombolysis Before Thrombectomy for Stroke

 


USPSTF Statement: Interventions for tobacco smoking cessation in adults

20 Jan, 2021 | 01:32h | UTC

Interventions for Tobacco Smoking Cessation in Adults, Including Pregnant Persons – U.S. Preventive Services Task Force

Editorial: A Comprehensive Approach to Increase Adult Tobacco Cessation – JAMA

Author Interview: USPSTF Recommendation: Tobacco Cessation in Adults

JAMA Patient Page: Interventions to Promote Tobacco Cessation

 


Guideline synopsis: Initiating Pharmacologic Treatment in Tobacco-Dependent Adults

20 Jan, 2021 | 01:31h | UTC

Initiating Pharmacologic Treatment in Tobacco-Dependent Adults – JAMA (free for a limited period)

Author Interview: Pharmacologic Management of Tobacco Cessation

Original Guideline: Initiating Pharmacologic Treatment in Tobacco-Dependent Adults. An Official American Thoracic Society Clinical Practice Guideline – American Journal of Respiratory and Critical Care Medicine

 


An epidemic of overdiagnosis: Melanoma diagnoses sky rocket

20 Jan, 2021 | 01:30h | UTC

An epidemic of overdiagnosis: Melanoma diagnoses sky rocket – Brigham and Women’s Hospital AND Does Screening for Skin Cancer Result in Melanoma Overdiagnosis? – Univadis

Original study: The Rapid Rise in Cutaneous Melanoma Diagnoses ($)

Related: Overdiagnosis: what it is and what it isn’t – BMJ Evidence Based Medicine (free) AND Overdiagnosis across medical disciplines: a scoping review – The BMJ Open (free) AND Too much medical care: bad for you, bad for health care systems – STAT News (free) AND Screening: How overdiagnosis and other harms can undermine the benefits – Health News Review (free) AND Overdiagnosis: causes and consequences in primary health care – Canadian Family Physician (free) AND Five warning signs of overdiagnosis – The Conversation (free) AND What is overdiagnosed cancer? And why does it matter? – Croakey (free) AND Blame rising cancer overdiagnosis on ‘irrational exuberance’ for early detection – STAT (free) AND Preventing overdiagnosis and the harms of too much sport and exercise medicine – British Journal of Sports Medicine (free)

 


Perspective – Sugar-sweetened beverage taxes: Lessons to date and the future of taxation

20 Jan, 2021 | 01:28h | UTC

Sugar-sweetened beverage taxes: Lessons to date and the future of taxation – PLOS Medicine

Related: Meta-Analysis: Impact of Sugar‐sweetened Beverage Taxes on Purchases and Dietary Intake (free study and resources on the subject)

 


Meta-analysis: Early initiation of renal replacement therapy is not associated with survival benefit in critically ill patients with acute kidney injury

20 Jan, 2021 | 01:25h | UTC

Timing of renal replacement therapy initiation for acute kidney injury in critically ill patients: a systematic review of randomized clinical trials with meta-analysis and trial sequential analysis – Critical Care

 


Meta-analysis: Inconclusive evidence regarding a benefit of systematic early mobilization in mechanically ventilated adult ICU patients

20 Jan, 2021 | 01:24h | UTC

Systematic early versus late mobilization or standard early mobilization in mechanically ventilated adult ICU patients: systematic review and meta-analysis – Critical Care

 


Science family of journals announces change to open-access policy

20 Jan, 2021 | 01:23h | UTC

Science family of journals announces change to open-access policy – Nature

See also: A new mandate highlights costs, benefits of making all scientific articles free to read – Science

Related: Open-access Science Funders Announce Price Transparency Rules for Publishers (several resources on the subject)

 


Meta-analysis: Comparison of the loop technique with incision and drainage for skin and soft tissue abscesses

20 Jan, 2021 | 01:22h | UTC

Comparison of the Loop Technique With Incision and Drainage for Skin and Soft Tissue Abscesses: A Systematic Review and Meta‐analysis – Academic Emergency Medicine

 

Commentary on Twitter

 


Randomized Trial of Focused Ultrasound Subthalamotomy for Parkinson’s Disease

20 Jan, 2021 | 01:20h | UTC

Randomized Trial of Focused Ultrasound Subthalamotomy for Parkinson’s Disease – New England Journal of Medicine

Commentary: Parkinson’s Motor Symptoms Improve with Focused Ultrasound — Adverse events were frequent, with some persisting 4 months or longer

 


Post-resuscitation shock: Recent advances in pathophysiology and treatment

20 Jan, 2021 | 01:18h | UTC

Post-resuscitation shock: recent advances in pathophysiology and treatment – Annals of Intensive Care

 


Epidural corticosteroid injections for sciatica: An abridged Cochrane systematic review and meta-analysis

20 Jan, 2021 | 01:16h | UTC

Epidural Corticosteroid Injections for Sciatica: An Abridged Cochrane Systematic Review and Meta-Analysis – Spine

Source: EvidenceAlerts

 


Role of imaging in visceral vascular emergencies

20 Jan, 2021 | 01:14h | UTC

Role of imaging in visceral vascular emergencies – Insights into Imaging

 


Systematic review: Intra-articular ketamine for postoperative analgesia

20 Jan, 2021 | 01:13h | UTC

A Systematic Review of Intra-Articular Ketamine for Postoperative Analgesia – American Journal of Physical Medicine & Rehabilitation

 

Commentary on Twitter

 


Systematic review: Insufficient evidence of benefit from immediate‐release methylphenidate for attention deficit hyperactivity disorder (ADHD) in adults

20 Jan, 2021 | 01:11h | UTC

IR methylphenidate for attention deficit hyperactivity disorder (ADHD) in adults – Cochrane Library

Original study: Immediate‐release methylphenidate for attention deficit hyperactivity disorder (ADHD) in adults – Cochrane Library

 


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