Genetics
How mRNA Technology Could Change the World
5 Apr, 2021 | 01:36h | UTCHow mRNA Technology Could Change the World – The Atlantic (a few articles per month are free)
RCT: Lumasiran, an RNAi Therapeutic for Primary Hyperoxaluria Type 1
5 Apr, 2021 | 01:01h | UTCLumasiran, an RNAi Therapeutic for Primary Hyperoxaluria Type 1 – New England Journal of Medicine (link to abstract – $ for full-text)
Another study indicates SARS-CoV-2 variant B.1.351, but not variant B.1.1.7, has partial resistance to neutralizing antibodies generated by natural infection or mRNA vaccination
28 Mar, 2021 | 22:53h | UTC
Commentaries on Twitter
Now a peer-reviewed pub in a top journal, this elegant study clearly shows that variant B.1.351 isn't stopped by antibodies from prior infection or the Pfizer vax. We'll have revised vaccines, but we don't yet. Please behave accordingly. https://t.co/w8GHPDB7aL
— EQV Analytics (@AnalyticsEqv) March 27, 2021
New @NatureMedicine, further data on immune response after vaccination to 2 variants, B.1.1.7 (UK) and B.1.351 (SA). Reinforcing recent reports, the latter is more of an immune evader, and may pose vulnerability for reinfection post-vaccinehttps://t.co/w8xFc3fkh5 pic.twitter.com/i7DAnjSZwE
— Eric Topol (@EricTopol) March 26, 2021
Opinion | The Coronavirus Variants Don’t Seem to Be Highly Variable So Far
28 Mar, 2021 | 22:46h | UTCThe Coronavirus Variants Don’t Seem to Be Highly Variable So Far – Scientific American
70-gene signature as an aid for treatment decisions in early breast cancer: updated results of the phase 3 randomised MINDACT trial with an exploratory analysis by age
14 Mar, 2021 | 20:07h | UTC70-gene signature as an aid for treatment decisions in early breast cancer: updated results of the phase 3 randomised MINDACT trial with an exploratory analysis by age – The Lancet Oncology (link to abstract – $ for full-text)
Position Statement: The Role of Pharmacogenomics in Contemporary Cardiovascular Therapy
11 Mar, 2021 | 07:53h | UTC
Clinical practice guidelines for BRCA1 and BRCA2 genetic testing
21 Feb, 2021 | 21:43h | UTCClinical practice guidelines for BRCA1 and BRCA2 genetic testing – European Journal of Cancer
Commentary on Twitter
BRCA1 and BRCA2 genetic testing- Clinical practice guidelineshttps://t.co/bpdXf70PnW pic.twitter.com/i6O0br35ap
— K Pavithran (@drkpavithran) February 15, 2021
BRUGADA-RISK: A primary prevention clinical risk score model for patients with Brugada Syndrome
18 Feb, 2021 | 02:57h | UTCCommentary: Risk Score Model for Brugada Syndrome – American College of Cardiology
Breast Cancer Risk Genes — Association Analysis in More than 113,000 Women
10 Feb, 2021 | 01:07h | UTC
A population-based study of genes previously implicated in breast cancer
10 Feb, 2021 | 01:05h | UTCA Population-Based Study of Genes Previously Implicated in Breast Cancer – New England Journal of Medicine (link to abstract – $ for full-text)
Consensus recommendations: Diagnosis and management of Bartter syndrome
3 Feb, 2021 | 01:04h | UTC
How Covid-19 mutations are changing the pandemic
29 Jan, 2021 | 01:55h | UTCHow Covid-19 mutations are changing the pandemic – BBC
NCCN Guideline: Genetic/familial high-risk assessment: breast, ovarian, and pancreatic
14 Jan, 2021 | 01:28h | UTC
New SARS-CoV-2 variants: increased transmissibility likely to cause more deaths and possibly a new wave of the disease
10 Jan, 2021 | 20:54h | UTC- SARS-CoV-2 Variants – World Health Organization
- Why epidemiologists are so worried about the new Covid-19 variants, in 2 charts – Vox
- We lost to SARS-CoV-2 in 2020. We can defeat B-117 in 2021 – STAT
- Transmission of SARS-CoV-2 Lineage B.1.1.7 in England: insights from linking epidemiological and genetic data – Imperial College of London AND Commentary: New COVID-19 variant growing rapidly in England – Imperial College London
- Genetic Variants of SARS-CoV-2—What Do They Mean? – JAMA
- Podcast: Understanding SARS-CoV-2 Genetic Variants – JAMA
- Podcast: Understanding the New SARS-CoV-2 Mutation Found in England – JAMA
- Viral mutations may cause another ‘very, very bad’ COVID-19 wave, scientists warn – Science
- Mutant coronavirus in the United Kingdom sets off alarms, but its importance remains unclear – Science
- New variant of SARS-CoV-2 in UK causes surge of COVID-19 – The Lancet Respiratory Medicine
- Scientists are monitoring a coronavirus mutation that could affect the strength of vaccines – STAT
- Instead of debating ‘first-shot’ vs. ‘set-aside’ vaccine approaches, hospitals’ study should compare them – STAT
- The Mutated Virus Is a Ticking Time Bomb – Vox
- What We Know About The New U.K. Variant Of Coronavirus — And What We Need To Find Out – NPR
- The New Mutations – Science Translational Medicine
- New Virus Strain’s Transmissibility to Cause More Deaths: Study – Bloomberg
- U.K. variant puts spotlight on immunocompromised patients’ role in the COVID-19 pandemic – Science
- When unusually severe COVID is seen, rapid identification-and-virus-sequencing are needed world-wide – Science Speaks: Global ID News
- Covid-19: New coronavirus variant is identified in UK – The BMJ
- The looming questions scientists need to answer about the new variant of the coronavirus – STAT
- With limited surveillance of Covid-19 variant, it’s déjà vu all over again – STAT
- New coronavirus variant: What do we know? – BBC
- Covid-19 in South Africa: Scientists seek to understand new variant – BBC
- New coronavirus variant: what is the spike protein and why are mutations on it important? – The Conversation
Down syndrome tied to 10 times the risk of COVID-19 death
23 Oct, 2020 | 09:13h | UTCDown syndrome tied to 10 times the risk of COVID-19 death – CIDRAP
Original study: COVID-19 Mortality Risk in Down Syndrome: Results From a Cohort Study Of 8 Million Adults – Annals of Internal Medicine
Guidelines for care of adults with Down Syndrome
21 Oct, 2020 | 09:14h | UTCMedical Care of Adults With Down Syndrome: A Clinical Guideline – JAMA (free for a limited period)
Editorial: Guidelines for Care of Adults With Down Syndrome
WHO takes a position on genetically modified mosquitoes
21 Oct, 2020 | 09:02h | UTCWHO takes a position on genetically modified mosquitoes – World Health Organization
Position Statement: Evaluation of genetically modified mosquitoes for the control of vector-borne diseases – World Health Organization
Detection of SARS-CoV-2 with a CRISPR-based test
17 Sep, 2020 | 09:38h | UTCDetection of SARS-CoV-2 with a CRISPR-Based Test – New England Journal of Medicine
The coronavirus is mutating — does it matter?
9 Sep, 2020 | 09:35h | UTCThe coronavirus is mutating — does it matter? – Nature
[Abstract Only] Randomized trial: Once-daily, subcutaneous vosoritide therapy in children with achondroplasia
8 Sep, 2020 | 01:06h | UTC
Commentary on Twitter
NEW Research—Once-daily, subcutaneous vosoritide therapy in children with achondroplasia: a randomised, double-blind, phase 3, placebo-controlled, multicentre trial https://t.co/LbknV5D2yL pic.twitter.com/KQvRoC58pb
— The Lancet (@TheLancet) September 7, 2020
Guidelines for the diagnosis and management of hereditary hemorrhagic telangiectasia
8 Sep, 2020 | 00:59h | UTC
International consensus recommendations on the diagnostic work-up for malformations of cortical development
8 Sep, 2020 | 00:58h | UTC
‘CRISPR babies’ are still too risky, says influential panel
6 Sep, 2020 | 21:25h | UTC‘CRISPR babies’ are still too risky, says influential panel – Nature
COVID-19 and mRNA vaccines—first large test for a new approach
4 Sep, 2020 | 02:08h | UTCCOVID-19 and mRNA Vaccines—First Large Test for a New Approach – JAMA
Effects of a major deletion in the SARS-CoV-2 genome on the severity of infection and the inflammatory response
20 Aug, 2020 | 09:28h | UTC
Commentary on Twitter
NEW Research—Effects of a major deletion in the SARS-CoV-2 genome on the severity of infection and the inflammatory response: an observational cohort study
"The ∆382 variant of SARS-CoV-2 seems to be associated with a milder infection" https://t.co/D17675hk9i pic.twitter.com/LvrIQolaXD
— The Lancet (@TheLancet) August 19, 2020