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RCT | Field sobriety tests display insufficient accuracy for detecting THC-specific driving impairment

11 Aug, 2023 | 15:14h | UTC

Evaluation of Field Sobriety Tests for Identifying Drivers Under the Influence of Cannabis: A Randomized Clinical Trial – JAMA Psychiatry

See also: Visual Abstract

News Release: Can field sobriety tests identify drivers under the influence of cannabis? – University of California – San Diego

Commentary: Trained Officers Using Current Field Sobriety Tests May Misclassify Cannabis-Impaired Drivers – Psychiatric News Alert


Commentary on Twitter


Review | Adverse effects of antidepressant medications and their management in children and adolescents

9 Aug, 2023 | 15:25h | UTC

Adverse Effects of Antidepressant Medications and their Management in Children and Adolescents – Pharmacotherapy


M-A | Absence of evidence for antipsychotics in youth unipolar depression; limited evidence in bipolar depression

9 Aug, 2023 | 15:23h | UTC

Effectiveness of atypical antipsychotics for unipolar and bipolar depression in adolescents and young adults: A systematic review and meta-analysis – Journal of Affective Disorders


Cohort Study | Clozapine, but not olanzapine or quetiapine, linked with higher perimyocarditis and heart failure risk

8 Aug, 2023 | 13:14h | UTC

The association between exposure to clozapine, olanzapine, and quetiapine and the outcomes perimyocarditis and heart failure: A population-based cohort study – Psychiatry Research


Study | Gastric bypass linked to increased risk of non-alcohol substance use disorder

7 Aug, 2023 | 14:23h | UTC

Non-alcohol substance use disorder after bariatric surgery in the prospective, controlled Swedish Obese Subjects study – Obesity

News Release: Gastric bypass surgery associated with non-alcohol substance use disorder – Obesity – The Obesity Society


RCT | 52-week antidepressant adjunctive therapy did not lead to a statistically significant benefit over 8-week therapy in bipolar I depression

4 Aug, 2023 | 12:11h | UTC

Duration of Adjunctive Antidepressant Maintenance in Bipolar I Depression – New England Journal of Medicine (link to abstract – $ for full-text)

News Release: Modern antidepressants may reduce risk of relapse for patients with bipolar depression – University of British Columbia


Commentary on Twitter


Cohort Study | Increased mortality rates in delirium tremens patients versus alcohol withdrawal or dependence

3 Aug, 2023 | 13:35h | UTC

Mortality and alcohol-related morbidity in patients with delirium tremens, alcohol withdrawal state or alcohol dependence in Norway: A register-based prospective cohort study – Addiction


Study | Increasing alcohol-related mortality rates in US women, 1999-2020

3 Aug, 2023 | 13:20h | UTC

Trends in Alcohol-Related Deaths by Sex in the US, 1999-2020 – JAMA Network Open

Commentary: As alcohol-related deaths rise in the US, women are increasingly at risk, study shows – CNN


Evidence Review | AA and other 12-step programs outperform CBT for alcohol use disorder

2 Aug, 2023 | 14:05h | UTC

Alcohol dependence: evidence and experience on 12 steps to recovery – Evidently Cochrane

Original study: Alcoholics Anonymous and other 12‐step programs for alcohol use disorder – Cochrane Library


Cohort Study | Depression at any life stage linked to increased dementia incidence

2 Aug, 2023 | 13:49h | UTC

Association of Early-, Middle-, and Late-Life Depression With Incident Dementia in a Danish Cohort – JAMA Neurology (link to abstract – $ for full-text)

Commentary: Depression Over Adulthood May Increase Risk of Dementia – Psychiatric News Alert


Systematic Review | Organizational changes likely decrease physical restraint usage in long-term care

31 Jul, 2023 | 13:53h | UTC

Interventions for preventing and reducing the use of physical restraints for older people in all long‐term care settings – Cochrane Library

Summary: Interventions for preventing and reducing the use of physical restraints in all long-term care settings – Cochrane Library


Phase 2 Trial | Oral orexin receptor 2 agonist shows promise in narcolepsy type 1, but raises hepatotoxic concerns

28 Jul, 2023 | 14:09h | UTC

Oral Orexin Receptor 2 Agonist in Narcolepsy Type 1 – New England Journal of Medicine (link to abstract – $ for full-text)


Commentary on Twitter


RCT | Zuranolone, a potential rapid-acting oral treatment for severe postpartum depression

27 Jul, 2023 | 13:00h | UTC

Zuranolone for the Treatment of Postpartum Depression – American Journal of Psychiatry (link to abstract – $ for full-text)

Commentary: Postpartum Depression Pill Zuralonone Shows Promise in Women With Severe Symptoms – Psychiatric News Alert

Related: RCT | Zuranolone outperforms placebo in major depressive disorder treatment


Mitigating neurological, cognitive, and psychiatric sequelae of COVID-19-related critical illness

26 Jul, 2023 | 13:28h | UTC

Mitigating neurological, cognitive, and psychiatric sequelae of COVID-19-related critical illness – The Lancet Respiratory Medicine


Systematic Review | Existing research on post-stroke depression interventions lacks conclusive results

25 Jul, 2023 | 13:37h | UTC

Pharmacological, non‐invasive brain stimulation and psychological interventions, and their combination, for treating depression after stroke – Cochrane Library

Summary: Pharmacological, non-invasive brain stimulation and psychological interventions for treating depression after stroke – Cochrane Library


Cohort Study | Increased risk of depression and suicide among people with HIV, especially in the first two years post-diagnosis

24 Jul, 2023 | 13:01h | UTC

Risk of Depression in People With HIV: A nationwide population-based matched cohort study – Clinical Infectious Diseases


Commentary on Twitter


RCT | Online emotion regulation therapy yields significant reduction in adolescent self-injury

24 Jul, 2023 | 12:39h | UTC

Effect of Internet-Delivered Emotion Regulation Individual Therapy for Adolescents With Nonsuicidal Self-Injury Disorder: A Randomized Clinical Trial – JAMA Network Open

See also: Visual Abstract

News Release: Internet-based therapy effective against self-harm in adolescents – Karolinska Institutes


Cohort Study | Bipolar disorder associated with a 6-fold higher mortality risk from external causes

21 Jul, 2023 | 13:29h | UTC

Cause-specific excess mortality after first diagnosis of bipolar disorder: population-based cohort study – BMJ Mental Health

News Release: Bipolar disorder linked to 6-fold heightened risk of early death from external causes – BMJ Newsroom


M-A | Adverse effects of antipsychotics on sleep in patients with schizophrenia

18 Jul, 2023 | 13:45h | UTC

Adverse effects of antipsychotics on sleep in patients with schizophrenia. Systematic review and meta-analysis – Frontiers in Psychiatry


RCT | Placebo equally effective as cognitive-behavioral therapy and aripiprazole in preventing psychosis transition

18 Jul, 2023 | 13:37h | UTC

Prevention of First-Episode Psychosis in People at Clinical High Risk: A Randomized Controlled, Multicentre Trial Comparing Cognitive-Behavioral Therapy and Clinical Management Plus Low-Dose Aripiprazole or Placebo (PREVENT) – Schizophrenia Bulletin (link to abstract – $ for full-text)

Commentary: Aripiprazole or CBT Not More Effective Than Placebo at Preventing Transition to Psychosis – Neurology Advisor


Meta-Analysis | Nearly 6% of first-episode psychosis patients exhibit clinically relevant MRI abnormalities

17 Jul, 2023 | 13:32h | UTC

Prevalence of Neuroradiological Abnormalities in First-Episode Psychosis: A Systematic Review and Meta-analysis – JAMA Psychiatry

News Release: Routine brain scanning may improve clinical care for people with psychosis – University of Oxford


Cohort Study | Mental disorders linked to increased cardiovascular events in young patients

17 Jul, 2023 | 13:20h | UTC

Increased cardiovascular events in young patients with mental disorders: a nationwide cohort study – European Journal of Preventive Cardiology (free for a limited period)

News Release: Under 40s with mental health problems have elevated risks of heart attack and stroke – European Society of Cardiology


RCT | 4-week course of subcutaneous ketamine shows efficacy in treatment-resistant depression

17 Jul, 2023 | 13:17h | UTC

Efficacy and safety of a 4-week course of repeated subcutaneous ketamine injections for treatment-resistant depression (KADS study): randomised double-blind active-controlled trial – British Journal of Psychiatry

News Release: Ketamine effective for treatment-resistant depression: Clinical trial – University of New South Wales


RCT | Ketamine non-Inferiority to ECT for nonpsychotic resistant depression

M-A | Electroconvulsive therapy may be superior to ketamine for patients with major depressive episode

RCT | Assessing low-dose ketamine’s antidepressant & antisuicidal effects in patients with treatment-resistant depression

M-A | Efficacy and safety of ketamine vs. electroconvulsive therapy among patients with major depressive episode.


Clinical practice guideline for deprescribing opioid analgesics

12 Jul, 2023 | 13:58h | UTC

Clinical practice guideline for deprescribing opioid analgesics: summary of recommendations – Medical Journal of Australia


RCT | Opioids not more effective than placebo for acute low back and neck pain

Deprescribing considerations for older people in general practice – Australian Journal of General Practice

Deprescribing Strategies for Opioids and Benzodiazepines with Emphasis on Concurrent Use: A Scoping Review – Journal of Clinical Medicine

An Overview of Systematic Reviews and Meta-Analyses on the Effect of Medication Interventions Targeting Polypharmacy for Frail Older Adults – Journal of Clinical Medicine

Physician-led medication reviews in polypharmacy patients treated with at least 12 medications in a type 2 diabetes outpatient clinic: a randomised trial – Diabetic Medicine

RCT | A deprescribing intervention reduced medication burden among older adults in post-acute care

Achieving sustainable healthcare through deprescribing of unnecessary medications: making sense of the evidence – Cochrane Library

Deprescribing medicines in older people living with multimorbidity and polypharmacy: the TAILOR evidence synthesis – Health Technology Assessment

Barriers and facilitators to deprescribing of cardiovascular medications: a systematic review – BMJ Open

A National Modified Delphi Consensus Process to Prioritize Experiences and Interventions for Antipsychotic Medication Deprescribing Among Adult Patients With Critical Illness – Critical Care Explorations

Deprescribing proton pump inhibitors – Australian Journal of General Practice

Medication reviews and deprescribing as a single intervention in falls prevention: a systematic review and meta-analysis – Age and Ageing

Optimizing Medication Use in Older Adults With Rheumatic Musculoskeletal Diseases: Deprescribing as an Approach When Less May Be More – ACP Open Rheumatology

Facing the challenge of polypharmacy when prescribing for older people with cardiovascular disease. A review by the European Society of Cardiology Working Group on Cardiovascular Pharmacotherapy – European Heart Journal – Cardiovascular Pharmacotherapy

Deprescribing in Older Adults with Cardiovascular Disease – Journal of the American College of Cardiology

Multimorbidity in Older Adults with Cardiovascular Disease – American College of Cardiology, Latest in Cardiology

Antihypertensive Deprescribing in Older Adults: a Practical Guide – Current Hypertension Reports

How-to guide for medication reviews in older adults with cancer: A Young International Society of Geriatric Oncology and Nursing & Allied Health Interest Group initiative – Journal of Geriatric Oncology

Deprescribing in Palliative Cancer Care – Life

Less is More: Deprescribing Medications in Older Adults with Kidney Disease: A Review – Kidney360

Process evaluation of implementation strategies to reduce potentially inappropriate medication prescribing in older population: A scoping review – Research in Social and Administrative Pharmacy

AGA Clinical Practice Update on De-Prescribing of Proton Pump Inhibitors: Expert Review – Gastroenterology

Development of a Metric to Detect and Decrease Low-Value Prescribing in Older Adults – JAMA Network Open

The MedSafer Study—Electronic Decision Support for Deprescribing in Hospitalized Older Adults: A Cluster Randomized Clinical Trial – JAMA Internal Medicine

Quantifying Anticholinergic Burden and Sedative Load in Older Adults with Polypharmacy: A Systematic Review of Risk Scales and Models – Drugs & Aging

Deprescribing in palliative patients with cancer: a concise review of tools and guidelines – Supportive Care in Cancer

Prescribing practices, patterns, and potential harms in patients receiving palliative care: A systematic scoping review – Exploratory Research in Clinical and Social Pharmacy

A narrative review of evidence to guide deprescribing among older adults – Journal of General and Family Medicine

Polypharmacy, inappropriate prescribing, and deprescribing in older people: through a sex and gender lens – The Lancet Health Longevity

Polypharmacy Management in Older Patients – Mayo Clinic Proceedings

Psychopharmacological Treatment in Older People: Avoiding Drug Interactions and Polypharmacy – Deutsches Ärzteblatt international

Eliminating Medication Overload: A National Action Plan – Lown Institute

International Group for Reducing Inappropriate Medication Use & Polypharmacy (IGRIMUP): Position Statement and 10 Recommendations for Action – Drugs & Aging

Common ED Medication Errors: Polypharmacy – emDocs

Current and future perspectives on the management of polypharmacy – BMC Family Practice

Routine deprescribing of chronic medications to combat polypharmacy – Therapeutic Advances in Drug Safety

Polypharmacy—an Upward Trend with Unpredictable Effects – Deutsches Ärzteblatt international

Clinical Consequences of Polypharmacy in Elderly – Expert Opinion on Drug Safety


USPSTF | Routine depression screening recommended for adults including pregnant and postpartum women

11 Jul, 2023 | 14:09h | UTC

Screening for Depression and Suicide Risk in Adults: US Preventive Services Task Force Recommendation Statement – JAMA

Evidence Report: Depression and Suicide Risk Screening: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force – JAMA

Patient Page: Screening for Depression and Suicide Risk in Adults – JAMA


Reframing the Key Questions Regarding Screening for Suicide Risk – JAMA

Suicidality Screening Guidelines Highlight the Need for Intervention Studies – JAMA Network Open


USPSTF Recommendations | Screen for anxiety disorders in adults, including pregnant and postpartum women

USPSTF Statement | Screening for anxiety is recommended in children and adolescents aged 8 to 18 years.

USPSTF Statement | Screening for depression and suicide risk is recommended in children and adolescents aged 12 to 18 years.


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