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Transplantation – Kidney

Extracorporeal CPR dissemination and integration with organ preservation in the USA: ethical and logistical considerations

28 Apr, 2023 | 12:47h | UTC

Extracorporeal cardiopulmonary resuscitation dissemination and integration with organ preservation in the USA: ethical and logistical considerations – Critical Care

 


Expanding Organ Usage: UK study finds organs from patients with a primary brain tumor are a viable option

27 Mar, 2023 | 13:27h | UTC

Summary: A national cohort study in the UK investigated the risk of cancer transmission from deceased donors with primary brain tumors to organ recipients. The study found no cases of brain tumor transmission among 778 transplants from 282 donors with primary brain tumors, including 262 from donors with high-grade tumors. Organ transplant survival was equivalent to that in matched controls, and some organs from donors with high-grade tumors were less likely to be transplanted.

The results suggest that the risk of cancer transmission in transplants from deceased donors with primary brain tumors is lower than previously thought. Furthermore, the study indicated that donors with brain tumors provided good-quality organs with favorable risk markers and excellent transplant outcomes. Some organs from donors with high-grade tumors were underutilized, indicating a possible aversion by transplant clinicians or patients to use these organs.

These findings imply that it may be possible to safely expand organ usage from donors with primary brain tumors without negatively impacting outcomes, potentially benefiting many patients waiting for a transplant. Although this might lead to a slight rise in transplant numbers in the UK, the findings may hold particular significance for nations with stricter guidelines, such as the United States. The study’s findings can help transplant clinicians discuss the risks and benefits of accepting organ offers from such donors.

Article: Organ Transplants From Deceased Donors With Primary Brain Tumors and Risk of Cancer Transmission – JAMA Surgery

 


RCT | Machine perfusion is superior to therapeutic hypothermia for reducing delayed graft function after kidney transplantation

6 Feb, 2023 | 13:28h | UTC

Hypothermia or Machine Perfusion in Kidney Donors – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Machine Perfusion of Kidneys Protects Against Delayed Graft Function – HealthDay

 

Commentary with video on Twitter

 


RCT | Sodium bicarbonate over 2 years was not beneficial for kidney transplant recipients with metabolic acidosis

27 Jan, 2023 | 12:23h | UTC

Sodium bicarbonate for kidney transplant recipients with metabolic acidosis in Switzerland: a multicentre, randomised, single-blind, placebo-controlled, phase 3 trial – The Lancet (link to abstract – $ for full-text)

 


Guidelines | Enhanced recovery after surgery recommendations for renal transplantation

20 Jan, 2023 | 14:51h | UTC

Enhanced recovery after surgery recommendations for renal transplantation: guidelines – British Journal of Surgery

Related:

Complete List of Enhanced Recovery After Surgery (ERAS) Society Guidelines

Top 100 Most-Cited Articles on Enhanced Recovery After Surgery: A Bibliometric Analysis and Visualized Study – Frontiers in Surgery

 

Commentary on Twitter

 


Recommendations for living donor kidney transplantation

10 Jan, 2023 | 14:39h | UTC

Recommendations for living donor kidney transplantation – Nefrología

 


Guidance on developing and/or expanding pediatric solid organ transplantation programs in low- and middle-income countries.

6 Dec, 2022 | 13:47h | UTC

International pediatric transplant association (IPTA) guidance on developing and/or expanding pediatric solid organ transplantation programs in low- and middle-income countries – Pediatric Transplantation

 


Review | Long-term medical outcomes of living kidney donors.

27 Nov, 2022 | 22:04h | UTC

Long-term Medical Outcomes of Living Kidney Donors – Mayo Clinic Proceedings

 


SR | Pregnancy after living kidney donation.

8 Nov, 2022 | 11:56h | UTC

Pregnancy after living kidney donation, a systematic review of the available evidence, and a review of the current guidance – American Journal of Transplantation

Video: Pregnancy after living kidney donation, a review of the available evidence and current guidance

 


AHA Scientific Statement | Emerging evidence on coronary heart disease screening in kidney and liver transplantation candidates.

24 Oct, 2022 | 14:11h | UTC

Emerging Evidence on Coronary Heart Disease Screening in Kidney and Liver Transplantation Candidates: A Scientific Statement From the American Heart Association – Circulation (PDF)

Top Things to Know: Emerging Evidence on Coronary Heart Disease (CHD) Screening in Kidney and Liver Transplantation Candidates – American Heart Association

Commentary: Trials and Tribulations of Cardiac Screening Asymptomatic Kidney and Liver Transplant Candidates – American Heart Association

 


Guideline | Management of kidney transplant patients with HLA antibodies.

31 Aug, 2022 | 11:47h | UTC

European Guideline for the Management of Kidney Transplant Patients With HLA Antibodies: By the European Society for Organ Transplantation Working Group – Transplant International

 


RCT: Effect of perioperative dexmedetomidine on delayed graft function following a donation-after-cardiac-death kidney transplant.

7 Jun, 2022 | 10:55h | UTC

Effect of Perioperative Dexmedetomidine on Delayed Graft Function Following a Donation-After-Cardiac-Death Kidney Transplant: A Randomized Clinical Trial – JAMA Network Open

 

Commentary on Twitter

 


M-A: Risks for donors associated with living kidney donation.

31 May, 2022 | 11:23h | UTC

Risks for donors associated with living kidney donation: meta-analysis – British Journal of Surgery

 

Commentary from the author on Twitter (thread – click for more)

Under a https://creativecommons.org/licenses/by-nc/4.0/ license

 


Results of two cases of pig-to-human kidney xenotransplantation.

19 May, 2022 | 11:11h | UTC

Results of Two Cases of Pig-to-Human Kidney Xenotransplantation – New England Journal of Medicine (link to abstract – $ for full-text)

 

Commentary on Twitter

 


Bring it on: Top five antimicrobial stewardship challenges in transplant infectious diseases and practical strategies to address them.

29 Apr, 2022 | 10:51h | UTC

Bring it on: Top five antimicrobial stewardship challenges in transplant infectious diseases and practical strategies to address them – Antimicrobial Stewardship & Healthcare Epidemiology

 

Commentary on Twitter

Under a http://creativecommons.org/licenses/by/4.0/ license

 


Opinion: Moving xenotransplantation research into human trials will require adjusting our expectations, researchers say.

6 Apr, 2022 | 09:59h | UTC

Moving xenotransplantation research into human trials will require adjusting our expectations, researchers say – STAT

Related:

After a flurry of firsts, xenotransplantation is suddenly back in the spotlight.

In 1st, US surgeons transplant pig heart into human patient.

 


M-A: The impact of cold ischemia time on outcomes of living donor kidney transplantation.

24 Mar, 2022 | 08:33h | UTC

The Impact of Cold Ischaemia Time on Outcomes of Living Donor Kidney Transplantation: A Systematic Review and Meta-Analysis – Journal of Clinical Medicine

 


Editorial: Pig-to-human transplants take a leap toward reality.

22 Mar, 2022 | 08:31h | UTC

Pig-to-human transplants take a leap toward reality – Nature Medicine

 


M-A: Survival for waitlisted kidney failure patients receiving transplantation vs. remaining on waiting list.

2 Mar, 2022 | 08:46h | UTC

Survival for waitlisted kidney failure patients receiving transplantation versus remaining on waiting list: systematic review and meta-analysis – The BMJ

 


In a series of simultaneous pancreas and kidney transplantation cases, long-term data demonstrated that patient and graft survival were equivalent for conventional donation after circulatory death (DCD) vs. donation after brainstem death. The utilization of DCD pancreases may expand the donor pool with comparable results to DBD transplantation.

7 Feb, 2022 | 08:24h | UTC

Outcomes for circulatory death and brainstem death pancreas transplantation with or without use of normothermic regional perfusion – British Journal of Surgery

 


Review: Post-transplant cardiovascular disease.

7 Feb, 2022 | 08:20h | UTC

Post-Transplant Cardiovascular Disease – Clinical Journal of the American Society of Nephrology

 


Thinking outside the box: novel kidney protective strategies in kidney transplantation.

7 Feb, 2022 | 08:16h | UTC

Thinking Outside the Box: Novel Kidney Protective Strategies in Kidney Transplantation – Clinical Journal of the American Society of Nephrology

 


After a flurry of firsts, xenotransplantation is suddenly back in the spotlight.

25 Jan, 2022 | 09:09h | UTC

After a flurry of firsts, xenotransplantation is suddenly back in the spotlight – STAT

Related: In 1st, US surgeons transplant pig heart into human patient.

 


RCT: Maribavir for refractory Cytomegalovirus infections with or without resistance post-transplant.

7 Dec, 2021 | 08:37h | UTC

Maribavir for Refractory Cytomegalovirus Infections With or Without Resistance Post-Transplant: Results from a Phase 3 Randomized Clinical Trial – Clinical Infectious Diseases

 


Recurrent Glomerular Disease after Kidney Transplantation: Diagnostic and Management Dilemmas.

28 Oct, 2021 | 09:43h | UTC

Recurrent Glomerular Disease after Kidney Transplantation: Diagnostic and Management Dilemmas – Clinical Journal of the American Society of Nephrology

 

Commentary on Twitter

 


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