Transplantation – Kidney
Cohort Study | Proton pump inhibitor use linked to increased fatigue in kidney transplant recipients
26 Jul, 2023 | 13:21h | UTC
Commentary on Twitter
Proton Pump Inhibitor Use, Fatigue, and Health-Related Quality of Life in Kidney Transplant Recipients: Results From the TransplantLines Biobank and Cohort Study https://t.co/DkDTvs9zjo #OpenAccess#VisualAbstract @umcg pic.twitter.com/XooY16qFVT
— AJKD (@AJKDonline) July 25, 2023
AHA Statement | Indications, evaluation, and outcomes for dual heart-kidney and heart-liver transplantation
14 Jul, 2023 | 12:51h | UTC
RCT | Substituting saline with balanced crystalloid solution reduces delayed graft function in kidney transplantation
30 Jun, 2023 | 14:56h | UTCSummary: The BEST-Fluids study was a pragmatic, multicentre, double-blind, randomized controlled trial carried out across 16 hospitals in Australia and New Zealand, aimed at comparing the use of balanced crystalloid solution (Plasma-Lyte 148) and saline in deceased donor kidney transplantation. The sample size comprised of 808 participants, who were either adults or children of any age, with the primary outcome defined as delayed graft function (DGF) occurring within 7 days post-transplantation.
Findings from the trial revealed that the balanced crystalloid group experienced less DGF than the saline group, with 121 out of 404 participants (30%) and 160 out of 403 participants (40%), respectively. This result yields an adjusted relative risk of 0.74 and an adjusted risk difference of 10.1%.
The study suggests that balanced crystalloid solution significantly reduces the incidence of DGF compared to saline. As no significant safety concerns were raised during the trial, the researchers recommend the use of balanced crystalloid solution as the standard-of-care intravenous fluid in deceased donor kidney transplantation. However, the study doesn’t indicate any significant differences in graft failure or mortality rates, which calls for further research.
Article: Balanced crystalloid solution versus saline in deceased donor kidney transplantation (BEST-Fluids): a pragmatic, double-blind, randomised, controlled trial – The Lancet (free registration required)
RCT | No change in delayed graft function with normothermic perfusion vs. cold storage in kidney transplants
13 Jun, 2023 | 14:00h | UTC
Commentary on Twitter
In an open-label, randomized controlled trial, normothermic machine perfusion of kidneys from donation after circulatory death was found to be feasible and safe but did not reduce the rate of delayed graft function compared to static cold storage. https://t.co/faaAzK3bpc pic.twitter.com/iL7Je7Z7jO
— Nature Medicine (@NatureMedicine) June 2, 2023
RCT | Letermovir demonstrates noninferiority to valganciclovir for CMV prophylaxis in kidney transplantation
12 Jun, 2023 | 13:38h | UTCLetermovir vs Valganciclovir for Prophylaxis of Cytomegalovirus in High-Risk Kidney Transplant Recipients: A Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: A New Antiviral Option for Cytomegalovirus Prevention After Kidney Transplant – JAMA (free for a limited period)
See also: Visual Abstract
Extracorporeal CPR dissemination and integration with organ preservation in the USA: ethical and logistical considerations
28 Apr, 2023 | 12:47h | UTC
Expanding Organ Usage: UK study finds organs from patients with a primary brain tumor are a viable option
27 Mar, 2023 | 13:27h | UTCSummary: A national cohort study in the UK investigated the risk of cancer transmission from deceased donors with primary brain tumors to organ recipients. The study found no cases of brain tumor transmission among 778 transplants from 282 donors with primary brain tumors, including 262 from donors with high-grade tumors. Organ transplant survival was equivalent to that in matched controls, and some organs from donors with high-grade tumors were less likely to be transplanted.
The results suggest that the risk of cancer transmission in transplants from deceased donors with primary brain tumors is lower than previously thought. Furthermore, the study indicated that donors with brain tumors provided good-quality organs with favorable risk markers and excellent transplant outcomes. Some organs from donors with high-grade tumors were underutilized, indicating a possible aversion by transplant clinicians or patients to use these organs.
These findings imply that it may be possible to safely expand organ usage from donors with primary brain tumors without negatively impacting outcomes, potentially benefiting many patients waiting for a transplant. Although this might lead to a slight rise in transplant numbers in the UK, the findings may hold particular significance for nations with stricter guidelines, such as the United States. The study’s findings can help transplant clinicians discuss the risks and benefits of accepting organ offers from such donors.
RCT | Machine perfusion is superior to therapeutic hypothermia for reducing delayed graft function after kidney transplantation
6 Feb, 2023 | 13:28h | UTCHypothermia or Machine Perfusion in Kidney Donors – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Machine Perfusion of Kidneys Protects Against Delayed Graft Function – HealthDay
Commentary with video on Twitter
Hypothermia of brain-dead kidney donors and machine perfusion of the kidney can reduce delayed graft function, but whether hypothermia is as effective as machine perfusion is unclear. New research findings are summarized in a short video. https://t.co/mL0YQZYoK1 pic.twitter.com/ANnJl27mkl
— NEJM (@NEJM) February 4, 2023
RCT | Sodium bicarbonate over 2 years was not beneficial for kidney transplant recipients with metabolic acidosis
27 Jan, 2023 | 12:23h | UTCSodium bicarbonate for kidney transplant recipients with metabolic acidosis in Switzerland: a multicentre, randomised, single-blind, placebo-controlled, phase 3 trial – The Lancet (link to abstract – $ for full-text)
Guidelines | Enhanced recovery after surgery recommendations for renal transplantation
20 Jan, 2023 | 14:51h | UTCRelated:
Complete List of Enhanced Recovery After Surgery (ERAS) Society Guidelines
Commentary on Twitter
Free to access in January's BJS: Enhanced recovery after surgery recommendations for renal transplantation: guidelines https://t.co/VkTRQmDWRS @bplwijn @des_winter @ksoreide @MalinASund @evanscolorectal @nfmkok @paulo_sutt @robhinchliffe1 @young_bjs pic.twitter.com/7JQYrlZJnO
— BJS (@BJSurgery) December 30, 2022
Recommendations for living donor kidney transplantation
10 Jan, 2023 | 14:39h | UTCRecommendations for living donor kidney transplantation – Nefrología
Guidance on developing and/or expanding pediatric solid organ transplantation programs in low- and middle-income countries.
6 Dec, 2022 | 13:47h | UTC
Review | Long-term medical outcomes of living kidney donors.
27 Nov, 2022 | 22:04h | UTCLong-term Medical Outcomes of Living Kidney Donors – Mayo Clinic Proceedings
SR | Pregnancy after living kidney donation.
8 Nov, 2022 | 11:56h | UTCVideo: Pregnancy after living kidney donation, a review of the available evidence and current guidance
AHA Scientific Statement | Emerging evidence on coronary heart disease screening in kidney and liver transplantation candidates.
24 Oct, 2022 | 14:11h | UTCTop Things to Know: Emerging Evidence on Coronary Heart Disease (CHD) Screening in Kidney and Liver Transplantation Candidates – American Heart Association
Guideline | Management of kidney transplant patients with HLA antibodies.
31 Aug, 2022 | 11:47h | UTC
RCT: Effect of perioperative dexmedetomidine on delayed graft function following a donation-after-cardiac-death kidney transplant.
7 Jun, 2022 | 10:55h | UTC
Commentary on Twitter
In this RCT, 24-hour dexmedetomidine infusion, started immediately after induction of & in addition to standard anesthesia, reduced the incidence of delayed graft function vs placebo, following a donation-after-cardiac-death kidney transplantation. https://t.co/cmX1IEZdVX
— JAMA Network Open (@JAMANetworkOpen) June 3, 2022
M-A: Risks for donors associated with living kidney donation.
31 May, 2022 | 11:23h | UTCRisks for donors associated with living kidney donation: meta-analysis – British Journal of Surgery
Commentary from the author on Twitter (thread – click for more)
#DiversityAndInclusion ??when counseling #Living #Kidney #Donors: our meta-analysis on the #risks stratified according to donor demographic characteristics has just been published @BJSurgery ?https://t.co/LtXpPeykiM @MichaelNozdrin @lisetpengel @transplantev ?1/7 pic.twitter.com/WszUiTAd1Q
— Maria Irene Bellini MD, PhD, FEBS (@mirenebellini1) May 26, 2022
Under a https://creativecommons.org/licenses/by-nc/4.0/ license
Results of two cases of pig-to-human kidney xenotransplantation.
19 May, 2022 | 11:11h | UTCResults of Two Cases of Pig-to-Human Kidney Xenotransplantation – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary on Twitter
Genetically modified pig kidney xenografts were transplanted into two brain-dead human recipients. The xenografts functioned immediately, showed no evidence of acute rejection over a period of 54 hours. https://t.co/gWlpX1dCTC pic.twitter.com/Zp5XdA4QH5
— NEJM (@NEJM) May 18, 2022
Bring it on: Top five antimicrobial stewardship challenges in transplant infectious diseases and practical strategies to address them.
29 Apr, 2022 | 10:51h | UTC
Commentary on Twitter
??Review Article @ASHE_Journal
Bring it on: Top five antimicrobial stewardship challenges in transplant infectious diseases and practical strategies to address them #IDTwitter #medtwitter #TwitteRx #MedEd https://t.co/ToPLQXtC4r pic.twitter.com/pZQWWb3ZSx— Antibiotic Steward Bassam Ghanem?? (@ABsteward) April 28, 2022
Under a http://creativecommons.org/licenses/by/4.0/ license
Opinion: Moving xenotransplantation research into human trials will require adjusting our expectations, researchers say.
6 Apr, 2022 | 09:59h | UTCRelated:
After a flurry of firsts, xenotransplantation is suddenly back in the spotlight.
In 1st, US surgeons transplant pig heart into human patient.
M-A: The impact of cold ischemia time on outcomes of living donor kidney transplantation.
24 Mar, 2022 | 08:33h | UTC
Editorial: Pig-to-human transplants take a leap toward reality.
22 Mar, 2022 | 08:31h | UTCPig-to-human transplants take a leap toward reality – Nature Medicine
M-A: Survival for waitlisted kidney failure patients receiving transplantation vs. remaining on waiting list.
2 Mar, 2022 | 08:46h | UTC
In a series of simultaneous pancreas and kidney transplantation cases, long-term data demonstrated that patient and graft survival were equivalent for conventional donation after circulatory death (DCD) vs. donation after brainstem death. The utilization of DCD pancreases may expand the donor pool with comparable results to DBD transplantation.
7 Feb, 2022 | 08:24h | UTC