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Transplantation – Kidney

Cohort Study | Proton pump inhibitor use linked to increased fatigue in kidney transplant recipients

26 Jul, 2023 | 13:21h | UTC

Proton Pump Inhibitor Use, Fatigue, and Health-Related Quality of Life in Kidney Transplant Recipients: Results From the TransplantLines Biobank and Cohort Study – American Journal of Kidney Diseases

 

Commentary on Twitter

 


AHA Statement | Indications, evaluation, and outcomes for dual heart-kidney and heart-liver transplantation

14 Jul, 2023 | 12:51h | UTC

Dual-Organ Transplantation: Indications, Evaluation, and Outcomes for Heart-Kidney and Heart-Liver Transplantation: A Scientific Statement From the American Heart Association – Circulation

 


RCT | Substituting saline with balanced crystalloid solution reduces delayed graft function in kidney transplantation

30 Jun, 2023 | 14:56h | UTC

Summary: The BEST-Fluids study was a pragmatic, multicentre, double-blind, randomized controlled trial carried out across 16 hospitals in Australia and New Zealand, aimed at comparing the use of balanced crystalloid solution (Plasma-Lyte 148) and saline in deceased donor kidney transplantation. The sample size comprised of 808 participants, who were either adults or children of any age, with the primary outcome defined as delayed graft function (DGF) occurring within 7 days post-transplantation.

Findings from the trial revealed that the balanced crystalloid group experienced less DGF than the saline group, with 121 out of 404 participants (30%) and 160 out of 403 participants (40%), respectively. This result yields an adjusted relative risk of 0.74 and an adjusted risk difference of 10.1%.

The study suggests that balanced crystalloid solution significantly reduces the incidence of DGF compared to saline. As no significant safety concerns were raised during the trial, the researchers recommend the use of balanced crystalloid solution as the standard-of-care intravenous fluid in deceased donor kidney transplantation. However, the study doesn’t indicate any significant differences in graft failure or mortality rates, which calls for further research.

Article: Balanced crystalloid solution versus saline in deceased donor kidney transplantation (BEST-Fluids): a pragmatic, double-blind, randomised, controlled trial – The Lancet (free registration required)

 


RCT | No change in delayed graft function with normothermic perfusion vs. cold storage in kidney transplants

13 Jun, 2023 | 14:00h | UTC

Normothermic machine perfusion versus static cold storage in donation after circulatory death kidney transplantation: a randomized controlled trial – Nature Medicine

 

Commentary on Twitter

 


RCT | Letermovir demonstrates noninferiority to valganciclovir for CMV prophylaxis in kidney transplantation

12 Jun, 2023 | 13:38h | UTC

Letermovir vs Valganciclovir for Prophylaxis of Cytomegalovirus in High-Risk Kidney Transplant Recipients: A Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: A New Antiviral Option for Cytomegalovirus Prevention After Kidney Transplant – JAMA (free for a limited period)

See also: Visual Abstract

Commentary: Newly approved antiviral is promising alternative against cytomegalovirus illness in kidney transplants – CIDRAP

 


Extracorporeal CPR dissemination and integration with organ preservation in the USA: ethical and logistical considerations

28 Apr, 2023 | 12:47h | UTC

Extracorporeal cardiopulmonary resuscitation dissemination and integration with organ preservation in the USA: ethical and logistical considerations – Critical Care

 


Expanding Organ Usage: UK study finds organs from patients with a primary brain tumor are a viable option

27 Mar, 2023 | 13:27h | UTC

Summary: A national cohort study in the UK investigated the risk of cancer transmission from deceased donors with primary brain tumors to organ recipients. The study found no cases of brain tumor transmission among 778 transplants from 282 donors with primary brain tumors, including 262 from donors with high-grade tumors. Organ transplant survival was equivalent to that in matched controls, and some organs from donors with high-grade tumors were less likely to be transplanted.

The results suggest that the risk of cancer transmission in transplants from deceased donors with primary brain tumors is lower than previously thought. Furthermore, the study indicated that donors with brain tumors provided good-quality organs with favorable risk markers and excellent transplant outcomes. Some organs from donors with high-grade tumors were underutilized, indicating a possible aversion by transplant clinicians or patients to use these organs.

These findings imply that it may be possible to safely expand organ usage from donors with primary brain tumors without negatively impacting outcomes, potentially benefiting many patients waiting for a transplant. Although this might lead to a slight rise in transplant numbers in the UK, the findings may hold particular significance for nations with stricter guidelines, such as the United States. The study’s findings can help transplant clinicians discuss the risks and benefits of accepting organ offers from such donors.

Article: Organ Transplants From Deceased Donors With Primary Brain Tumors and Risk of Cancer Transmission – JAMA Surgery

 


RCT | Machine perfusion is superior to therapeutic hypothermia for reducing delayed graft function after kidney transplantation

6 Feb, 2023 | 13:28h | UTC

Hypothermia or Machine Perfusion in Kidney Donors – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Machine Perfusion of Kidneys Protects Against Delayed Graft Function – HealthDay

 

Commentary with video on Twitter

 


RCT | Sodium bicarbonate over 2 years was not beneficial for kidney transplant recipients with metabolic acidosis

27 Jan, 2023 | 12:23h | UTC

Sodium bicarbonate for kidney transplant recipients with metabolic acidosis in Switzerland: a multicentre, randomised, single-blind, placebo-controlled, phase 3 trial – The Lancet (link to abstract – $ for full-text)

 


Guidelines | Enhanced recovery after surgery recommendations for renal transplantation

20 Jan, 2023 | 14:51h | UTC

Enhanced recovery after surgery recommendations for renal transplantation: guidelines – British Journal of Surgery

Related:

Complete List of Enhanced Recovery After Surgery (ERAS) Society Guidelines

Top 100 Most-Cited Articles on Enhanced Recovery After Surgery: A Bibliometric Analysis and Visualized Study – Frontiers in Surgery

 

Commentary on Twitter

 


Recommendations for living donor kidney transplantation

10 Jan, 2023 | 14:39h | UTC

Recommendations for living donor kidney transplantation – Nefrología

 


Guidance on developing and/or expanding pediatric solid organ transplantation programs in low- and middle-income countries.

6 Dec, 2022 | 13:47h | UTC

International pediatric transplant association (IPTA) guidance on developing and/or expanding pediatric solid organ transplantation programs in low- and middle-income countries – Pediatric Transplantation

 


Review | Long-term medical outcomes of living kidney donors.

27 Nov, 2022 | 22:04h | UTC

Long-term Medical Outcomes of Living Kidney Donors – Mayo Clinic Proceedings

 


SR | Pregnancy after living kidney donation.

8 Nov, 2022 | 11:56h | UTC

Pregnancy after living kidney donation, a systematic review of the available evidence, and a review of the current guidance – American Journal of Transplantation

Video: Pregnancy after living kidney donation, a review of the available evidence and current guidance

 


AHA Scientific Statement | Emerging evidence on coronary heart disease screening in kidney and liver transplantation candidates.

24 Oct, 2022 | 14:11h | UTC

Emerging Evidence on Coronary Heart Disease Screening in Kidney and Liver Transplantation Candidates: A Scientific Statement From the American Heart Association – Circulation (PDF)

Top Things to Know: Emerging Evidence on Coronary Heart Disease (CHD) Screening in Kidney and Liver Transplantation Candidates – American Heart Association

Commentary: Trials and Tribulations of Cardiac Screening Asymptomatic Kidney and Liver Transplant Candidates – American Heart Association

 


Guideline | Management of kidney transplant patients with HLA antibodies.

31 Aug, 2022 | 11:47h | UTC

European Guideline for the Management of Kidney Transplant Patients With HLA Antibodies: By the European Society for Organ Transplantation Working Group – Transplant International

 


RCT: Effect of perioperative dexmedetomidine on delayed graft function following a donation-after-cardiac-death kidney transplant.

7 Jun, 2022 | 10:55h | UTC

Effect of Perioperative Dexmedetomidine on Delayed Graft Function Following a Donation-After-Cardiac-Death Kidney Transplant: A Randomized Clinical Trial – JAMA Network Open

 

Commentary on Twitter

 


M-A: Risks for donors associated with living kidney donation.

31 May, 2022 | 11:23h | UTC

Risks for donors associated with living kidney donation: meta-analysis – British Journal of Surgery

 

Commentary from the author on Twitter (thread – click for more)

Under a https://creativecommons.org/licenses/by-nc/4.0/ license

 


Results of two cases of pig-to-human kidney xenotransplantation.

19 May, 2022 | 11:11h | UTC

Results of Two Cases of Pig-to-Human Kidney Xenotransplantation – New England Journal of Medicine (link to abstract – $ for full-text)

 

Commentary on Twitter

 


Bring it on: Top five antimicrobial stewardship challenges in transplant infectious diseases and practical strategies to address them.

29 Apr, 2022 | 10:51h | UTC

Bring it on: Top five antimicrobial stewardship challenges in transplant infectious diseases and practical strategies to address them – Antimicrobial Stewardship & Healthcare Epidemiology

 

Commentary on Twitter

Under a http://creativecommons.org/licenses/by/4.0/ license

 


Opinion: Moving xenotransplantation research into human trials will require adjusting our expectations, researchers say.

6 Apr, 2022 | 09:59h | UTC

Moving xenotransplantation research into human trials will require adjusting our expectations, researchers say – STAT

Related:

After a flurry of firsts, xenotransplantation is suddenly back in the spotlight.

In 1st, US surgeons transplant pig heart into human patient.

 


M-A: The impact of cold ischemia time on outcomes of living donor kidney transplantation.

24 Mar, 2022 | 08:33h | UTC

The Impact of Cold Ischaemia Time on Outcomes of Living Donor Kidney Transplantation: A Systematic Review and Meta-Analysis – Journal of Clinical Medicine

 


Editorial: Pig-to-human transplants take a leap toward reality.

22 Mar, 2022 | 08:31h | UTC

Pig-to-human transplants take a leap toward reality – Nature Medicine

 


M-A: Survival for waitlisted kidney failure patients receiving transplantation vs. remaining on waiting list.

2 Mar, 2022 | 08:46h | UTC

Survival for waitlisted kidney failure patients receiving transplantation versus remaining on waiting list: systematic review and meta-analysis – The BMJ

 


In a series of simultaneous pancreas and kidney transplantation cases, long-term data demonstrated that patient and graft survival were equivalent for conventional donation after circulatory death (DCD) vs. donation after brainstem death. The utilization of DCD pancreases may expand the donor pool with comparable results to DBD transplantation.

7 Feb, 2022 | 08:24h | UTC

Outcomes for circulatory death and brainstem death pancreas transplantation with or without use of normothermic regional perfusion – British Journal of Surgery

 


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