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Pediatrics – Neurology

M-A | Exploring perinatal interventions and their impact on severe intraventricular hemorrhage in preterm neonates

4 Aug, 2023 | 11:56h | UTC

Interventions to Reduce Severe Brain Injury Risk in Preterm Neonates: A Systematic Review and Meta-analysis – JAMA Network Open

 

Commentary on Twitter

 


Review | Treatment of pediatric convulsive status epilepticus

4 Aug, 2023 | 11:42h | UTC

Treatment of pediatric convulsive status epilepticus – Frontiers in Neurology

 


Prospective Study | Intelligence likely remains intact after pediatric concussion

20 Jul, 2023 | 11:06h | UTC

IQ After Pediatric Concussion – Pediatrics (free for a limited period)

Commentaries:

IQ After Pediatric Concussion: Clinical Considerations – Pediatrics

No Evidence Seen for Differences in IQ After Pediatric Concussion – HealthDay

Concussions do not affect IQ in children, study finds – News Medical

 


Nationwide Cohort Study | Adolescent hypertension linked with increased stroke risk in young adulthood

18 Jul, 2023 | 13:49h | UTC

Adolescent Hypertension Is Associated With Stroke in Young Adulthood: A Nationwide Cohort of 1.9 Million Adolescents – Stroke

Commentary: The Relationship Between Adolescent Hypertension and Stroke Risk After Age 40 Years – Neurology Advisor

 


Cohort Study | Long-term risk of epilepsy following invasive Group B Streptococcus disease in neonates

9 May, 2023 | 14:25h | UTC

Long-term Risk of Epilepsy Following Invasive Group B Streptococcus Disease in Neonates in Denmark – JAMA Network Open

 


RCT | Cerebral oximetry monitoring fails to reduce death or severe brain injury in extremely preterm infants

25 Apr, 2023 | 14:45h | UTC

Cerebral Oximetry Monitoring in Extremely Preterm Infants – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: No reduction in death or severe brain injury with cerebral oximetry monitoring in extremely preterm infants, finds study – MedicalXpress

 

Commentary on Twitter

 


M-A | Retinopathy of prematurity and neurodevelopmental outcomes in preterm infants

10 Apr, 2023 | 13:36h | UTC

Retinopathy of prematurity and neurodevelopmental outcomes in preterm infants: A systematic review and meta-analysis – Frontiers in Pediatrics

 


Review of noninvasive neuromonitoring modalities in children: EEG, qEEG

27 Mar, 2023 | 12:50h | UTC

Review of Noninvasive Neuromonitoring Modalities in Children II: EEG, qEEG – Neurocritical Care (if the link is paywalled, try this one)

 


RCT | Safety and efficacy of pitolisant in children aged 6 years or older with narcolepsy with or without cataplexy

23 Mar, 2023 | 12:44h | UTC

Safety and efficacy of pitolisant in children aged 6 years or older with narcolepsy with or without cataplexy: a double-blind, randomised, placebo-controlled trial – The Lancet Neurology (link to abstract – $ for full-text)

 


RCT | Impact of two ketogenic diet types in refractory childhood epilepsy

16 Mar, 2023 | 13:13h | UTC

Impact of two ketogenic diet types in refractory childhood epilepsy – Pediatric Research

Related:

Efficacy and Safety of Dietary Therapies for Childhood Drug-Resistant Epilepsy: A Systematic Review and Network Meta-analysis – JAMA Pediatrics (link to abstract – $ for full-text)

Safety, Efficacy, and Tolerability of Modified Atkins Diet in Persons With Drug-Resistant Epilepsy: A Randomized Controlled Trial – Neurology (link to abstract – $ for full-text)

Efficacy of Ketogenic Diet, Modified Atkins Diet, and Low Glycemic Index Therapy Diet Among Children With Drug-Resistant Epilepsy: A Randomized Clinical Trial – JAMA Pediatrics

 


SR | Surgical treatments for epilepsies in children aged 1–36 months

10 Mar, 2023 | 14:21h | UTC

Surgical Treatments for Epilepsies in Children Aged 1–36 Months: A Systematic Review – Neurology

 

Commentary on Twitter

 


10-year follow-up on preterm prelabor rupture of membranes: induced labor vs. expectant management childhood outcomes

16 Feb, 2023 | 15:05h | UTC

Summary: This study aimed to compare the long-term outcomes of children born after singleton pregnancies complicated by preterm prelabor rupture of membranes and managed by induction of labor vs. expectant management in RCTs undergone between 2007 and 2011. The study assessed the children’s cognition, motor function, and behavior as the primary outcomes. It found that expectant management did not improve long-term outcomes compared to induction of labor for children born after pregnancies with preterm prelabor (between 34 0/7 and 36 6/7 weeks of pregnancy) rupture of membranes. The confidence in the results of this follow-up study is diminished because only 35% of the children who participated in the original trials participated in the follow-up study.

Article: Childhood outcomes after induction of labor or expectant management for preterm prelabor rupture of membranes: a 10-year follow-up of the PPROMEXIL trials – American Journal of Obstetrics & Gynecology

 

*Note: This summary was created through the collaboration of a medical editor and ChatGPT.

 


Diagnostic Study | Level of attention to motherese speech as an early marker of autism spectrum disorder

14 Feb, 2023 | 11:04h | UTC

Summary: A study was conducted to determine if levels of attention to motherese speech can be used as a diagnostic marker for autism spectrum disorder (ASD) and if they are associated with social and language abilities. The study involved 653 toddlers aged 12 to 48 months and used gaze-contingent eye tracking to measure attention to motherese speech. The results showed that toddlers without ASD had high levels of fixation on motherese speech, while those with ASD had significantly reduced levels. If a toddler fixated on motherese speech at or below 30%, the probability of them being accurately diagnosed with ASD was 94%, and it was also associated with reduced social and language abilities. The findings suggest that attention to motherese speech may be a diagnostic and prognostic marker of ASD.

(By ChatGPT, reviewed and edited)

 

Article: Level of Attention to Motherese Speech as an Early Marker of Autism Spectrum Disorder – JAMA Network Open

Commentaries:

Attention to motherese speech is a promising early diagnostic marker for autism spectrum disorder – News Medical

Toddlers’ Attention to ‘Motherese’ Could Give Clues to Autism – HealthDay

 


Cohort Study | In utero exposure to ADHD medication does not seem to result in worse offspring neurodevelopmental outcomes

14 Feb, 2023 | 10:54h | UTC

Summary: The authors conducted a study to investigate the long-term effects of in utero exposure to ADHD medication (methylphenidate, amphetamine, dexamphetamine, lisdexamphetamine, modafinil, atomoxetine, clonidine) on offspring. The study followed 1,068,073 liveborn singletons from 1998 to 2018 and compared the outcomes of children whose mothers continued or discontinued ADHD medication during pregnancy. The main outcomes were neurodevelopmental psychiatric disorders, impairments in vision or hearing, epilepsy, seizures, or growth impairment during childhood or adolescence. After adjustment for demographic and psychiatric characteristics of the mother, no increased risk of any developmental disorders was found in offspring exposed to ADHD medication compared to those not exposed. The results provide reassurance for women with ADHD who depend on medication and consider continuing it during pregnancy.

(By ChatGPT, reviewed and edited)

 

Article: In utero exposure to ADHD medication and long-term offspring outcomes – Molecular Psychiatry (link to abstract – $ for full-text)

News Release: Study: Pregnant women on ADHD medications shouldn’t worry about pediatric neurodevelopmental disorders – The Mount Sinai Hospital

 

Commentary from the author on Twitter (thread – click for more)

 


M-A | Comparative antiseizure medications for adjunctive treatment in children with drug-resistant focal-onset seizures

9 Feb, 2023 | 13:22h | UTC

Comparative antiseizure medications of adjunctive treatment for children with drug-resistant focal-onset seizures: A systematic review and network meta-analysis – Frontiers in Pharmacology

 


Cohort Study | Neurodevelopmental outcomes after late-onset meningitis in children born extremely preterm

7 Feb, 2023 | 13:38h | UTC

Incidence of and Neurodevelopmental Outcomes After Late-Onset Meningitis Among Children Born Extremely Preterm – JAMA Network Open

Commentary: Late-Onset Meningitis ID’d in 1 Percent of Extreme Preemies – HealthDay

 

Commentary on Twitter

 


M-A | Effect of early childhood development interventions to improve cognitive outcomes in children at 0–36 months

6 Feb, 2023 | 13:14h | UTC

Effect of early childhood development interventions delivered by healthcare providers to improve cognitive outcomes in children at 0–36 months: a systematic review and meta-analysis – Archives of Disease in Childhood (free for a limited period)

 


M-A | Efficacy and safety of dietary therapies for childhood drug-resistant epilepsy

6 Feb, 2023 | 13:00h | UTC

Efficacy and Safety of Dietary Therapies for Childhood Drug-Resistant Epilepsy: A Systematic Review and Network Meta-analysis – JAMA Pediatrics (link to abstract – $ for full-text)

Related:

RCT | Safety, efficacy, and tolerability of modified Atkins diet in persons with drug-resistant epilepsy

Efficacy of Ketogenic Diet, Modified Atkins Diet, and Low Glycemic Index Therapy Diet Among Children With Drug-Resistant Epilepsy: A Randomized Clinical Trial – JAMA Pediatrics

 

Commentary on Twitter

 


Cohort Study | Associations between infant screen use, electroencephalography markers, and cognitive outcomes

1 Feb, 2023 | 13:34h | UTC

Associations Between Infant Screen Use, Electroencephalography Markers, and Cognitive Outcomes – JAMA Pediatrics

Commentaries:

Infant Screen Use Linked to Alterations in Cortical EEG Before Age 2 – HealthDay

Your child’s academic success may start with their screen time as infants, study says – CNN

 


RCT | Assessment of infant position and timing of stylet removal to improve lumbar puncture success in neonates

31 Jan, 2023 | 14:07h | UTC

Assessment of infant position and timing of stylet removal to improve lumbar puncture success in neonates (NeoCLEAR): an open-label, 2 × 2 factorial, randomised, controlled trial – The Lancet Child & Adolescent Health

News Release: Lumbar punctures in newborn babies are more successful when performed in sitting position – Oxford Population Health

 

Commentary on Twitter

 


SR | Prognosis of adults and children following a first unprovoked seizure

30 Jan, 2023 | 00:45h | UTC

Prognosis of adults and children following a first unprovoked seizure – Cochrane Library

Summary: Predicting a second seizure after a single unprovoked seizure – Cochrane Library

 


Review | Common sleep disorders in children

24 Jan, 2023 | 14:22h | UTC

Common Sleep Disorders in Children – American Family Physician

Note: AFP provides superb review articles that are freely available one year after publication.

 


RCT | Telehealth treatment of behavior problems in young children with developmental delay

20 Jan, 2023 | 14:38h | UTC

Telehealth Treatment of Behavior Problems in Young Children With Developmental Delay: A Randomized Clinical Trial – JAMA Pediatrics (link to abstract – $ for full-text)

Commentaries:

Telehealth parent-child interaction therapy improved behavior in children with developmental delay – MDedge

Telehealth Parent-Child Interaction Therapy Aids Child Behavior – HealthDay

 

Commentary on Twitter

 


Gestational age at birth and cognitive outcomes in adolescence: population based full sibling cohort study

19 Jan, 2023 | 14:27h | UTC

Gestational age at birth and cognitive outcomes in adolescence: population based full sibling cohort study – The BMJ

Editorial: Gestational age at birth and school performance – The BMJ

News Release: Premature birth linked to poorer school grades in adolescence – BMJ

 


Cohort Study | Neurodevelopmental disorders in offspring conceived via IVF vs. intracytoplasmic sperm injection

19 Jan, 2023 | 14:12h | UTC

Neurodevelopmental Disorders in Offspring Conceived via In Vitro Fertilization vs Intracytoplasmic Sperm Injection – JAMA Network Open

 


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