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Pediatrics – Neurology

M-A: Incidence and etiology of infant Gram-negative bacteremia and meningitis in children.

23 Jun, 2022 | 10:27h | UTC

Incidence and aetiology of infant Gram-negative bacteraemia and meningitis: systematic review and meta-analysis – Archives of Disease in Childhood

 

Artificial intelligence may detect autism speech patterns across different languages, study finds.

20 Jun, 2022 | 01:05h | UTC

News Release: AI detects autism speech patterns across different languages – Northwestern University

Original Study: Cross-linguistic patterns of speech prosodic differences in autism: A machine learning study – PLOS One

 

Single-arm phase 3 Trial: Onasemnogene abeparvovec for presymptomatic infants with three copies of SMN2 at risk for spinal muscular atrophy.

20 Jun, 2022 | 01:04h | UTC

Onasemnogene abeparvovec for presymptomatic infants with three copies of SMN2 at risk for spinal muscular atrophy: the Phase III SPR1NT trial – Nature Medicine

 

Commentary on Twitter

 

Cohort Study: Neurodevelopmental outcomes at 1 year in infants of mothers who tested positive for SARS-CoV-2 during pregnancy.

10 Jun, 2022 | 12:14h | UTC

Neurodevelopmental Outcomes at 1 Year in Infants of Mothers Who Tested Positive for SARS-CoV-2 During Pregnancy – JAMA Network Open

Commentaries:

Is It Exposure to the Pandemic or to Maternal SARS-CoV-2 Infection That Is Adversely Affecting Early Childhood Neurodevelopment? – JAMA Network Open

Expert reaction to observational study of mothers who tested positive for SARS-CoV-2 during pregnancy and neurodevelopmental outcomes in their children at 1 year – Science Media Centre

 

Commentary on Twitter

 

CDC Report: Pediatric melatonin ingestions in the US.

9 Jun, 2022 | 11:32h | UTC

Pediatric Melatonin Ingestions — United States, 2012–2021 – Morbidity and Mortality Weekly Report

Commentaries:

Thousands of kids are getting sick from downing melatonin pills – NPR

Melatonin poisoning reports are up in kids, study says – Associated Press

Melatonin Overdoses Among Kids Are Up 530%, New Research Finds – TIME

Reports of melatonin poisoning in kids have increased 530% since 2012 – Yahoo News

 

Commentary on Twitter

 

Management of sleep disorders among children and adolescents with neurodevelopmental disorders: A practical guide for clinicians.

9 Jun, 2022 | 11:21h | UTC

Management of sleep disorders among children and adolescents with neurodevelopmental disorders: A practical guide for clinicians – World Journal of Clinical Pediatrics

 

Consensus Statement: Assessment of foot alignment and function for ambulatory children with cerebral palsy.

9 Jun, 2022 | 10:59h | UTC

Assessment of foot alignment and function for ambulatory children with cerebral palsy: Results of a modified Delphi technique consensus study – Journal of Children’s Orthopaedics

 

M-A: Intelligence outcome of pediatric intensive care unit survivors.

8 Jun, 2022 | 10:36h | UTC

Intelligence outcome of pediatric intensive care unit survivors: a systematic meta-analysis and meta-regression – BMC Medicine

 

Cohort Study: Association of prenatal exposure to antiseizure medication with risk of autism and intellectual disability.

1 Jun, 2022 | 11:44h | UTC

Association of Prenatal Exposure to Antiseizure Medication With Risk of Autism and Intellectual Disability – JAMA Neurology

Author Interview: Prenatal Exposure to Antiseizure Medication With Risk of Autism and Intellectual Disability – JAMA

Commentaries:

Prenatal Exposure to Certain Antiseizure Meds Linked to Autism – HealthDay

Pregnant women who take common epilepsy drugs up to four times as likely to have child with autism or learning disabilities, study warns – Daily Mail

Related:

Risks of 23 specific malformations associated with prenatal exposure to 10 antiepileptic drugs – Neurology (link to abstract – $ for full-text)

Thirteen UK healthcare bodies launch ‘pragmatic’ guidance on valproate use – Royal College of General Practitioners

Association of Prenatal Exposure to Valproate and Other Antiepileptic Drugs With Risk for Attention-Deficit/Hyperactivity Disorder in Offspring – JAMA Network Open

Educational attainment of children born to mothers with epilepsy – Journal of Neurology, Neurosurgery, and Psychiatry (link to abstract – $ for full-text)

 

Commentary on Twitter

 

RCT: Efficacy and safety of fenfluramine for the treatment of seizures associated With Lennox-Gastaut Syndrome.

16 May, 2022 | 01:29h | UTC

Efficacy and Safety of Fenfluramine for the Treatment of Seizures Associated With Lennox-Gastaut Syndrome: A Randomized Clinical Trial – JAMA Neurology

Commentaries:

Fenfluramine Found Effective for Treatment of Lennox-Gastaut Syndrome Seizures – NeurologyToday

Fenfluramine Seems Effective for Lennox-Gastaut Syndrome – HealthDay

 

Commentary on Twitter

 

Review: Current status and future directions of neuromonitoring with emerging technologies in neonatal care.

5 May, 2022 | 09:47h | UTC

Current Status and Future Directions of Neuromonitoring With Emerging Technologies in Neonatal Care – Frontiers in Pediatrics

 

M-A: Efficacy and safety of Selumetinib in pediatric patients with Neurofibromatosis Type 1.

5 May, 2022 | 09:41h | UTC

Efficacy and Safety of Selumetinib in Pediatric Patients With Neurofibromatosis Type 1: A Systematic Review and Meta-analysis  – Neurology (link to abstract – $ for full-text)

Commentary: Selumetinib Significantly Decreased Tumor Burden in Children with Symptomatic Inoperable Plexiform Neurofibromas – Neurology Today

 

Commentary on Twitter

 

Review: The brain in pediatric critical care: unique aspects of assessment, monitoring, investigations, and follow-up.

25 Apr, 2022 | 00:26h | UTC

The brain in pediatric critical care: unique aspects of assessment, monitoring, investigations, and follow-up – Intensive Care Medicine

 

Commentary on Twitter

 

Cohort Study: Rates and causes of mortality among children and young people with and without intellectual disabilities in Scotland.

20 Apr, 2022 | 09:22h | UTC

Rates and causes of mortality among children and young people with and without intellectual disabilities in Scotland: a record linkage cohort study of 796 190 school children – BMJ Open

 

Commentary on Twitter

 

Cohort Study: Association of treatment with antipsychotics, antidepressants, or both with movement disorders and seizures among children and adolescents with depression.

19 Apr, 2022 | 01:50h | UTC

Association of Treatment With Antipsychotics, Antidepressants, or Both With Movement Disorders and Seizures Among Children and Adolescents With Depression in Korea – JAMA Network Open

 

Commentary on Twitter

 

RCT: Safety and efficacy of ganaxolone in patients with CDKL5 deficiency disorder.

19 Apr, 2022 | 01:20h | UTC

Safety and efficacy of ganaxolone in patients with CDKL5 deficiency disorder: results from the double-blind phase of a randomised, placebo-controlled, phase 3 trial – The Lancet Neurology (link to abstract – $ for full-text)

 

RCT: Effect of different corticosteroid dosing regimens on clinical outcomes in boys with Duchenne Muscular Dystrophy.

7 Apr, 2022 | 08:53h | UTC

Effect of Different Corticosteroid Dosing Regimens on Clinical Outcomes in Boys With Duchenne Muscular Dystrophy: A Randomized Clinical Trial – JAMA (free for a limited period)

Related:

RCT: Routine lung volume recruitment is not beneficial for boys with Duchenne muscular dystrophy.

Phase 2 RCT: Repeated intravenous cardiosphere-derived cell therapy in late-stage Duchenne muscular dystrophy.

Research: Long-term effects of glucocorticoids in patients with Duchenne muscular dystrophy

 

Commentary on Twitter

 

Association of antipsychotic drug exposure in pregnancy with risk of neurodevelopmental disorders: a national birth cohort study.

29 Mar, 2022 | 08:46h | UTC

Association of Antipsychotic Drug Exposure in Pregnancy With Risk of Neurodevelopmental Disorders: A National Birth Cohort Study – JAMA Internal Medicine (free for a limited period)

Commentary: Antipsychotic Use During Pregnancy Generally Not Associated With Neurodevelopmental Risks – Psychiatric News Alert

 

European clinical guidelines for Tourette syndrome and other tic disorders.

29 Mar, 2022 | 08:26h | UTC

Summary statement

Part I: assessment

Part II: psychological interventions

Part III: pharmacological treatment

Part IV: deep brain stimulation

Related: Guideline: Treatment of Tics in People with Tourette Syndrome and Chronic Tic Disorders

 

Cohort Study: Risk of mental health problems in children and youths following concussion.

25 Mar, 2022 | 08:29h | UTC

Risk of Mental Health Problems in Children and Youths Following Concussion – JAMA Network Open

Commentaries:

Contextual Considerations for the Increased Risk of Mental Health Problems Following Concussion in Youth – JAMA Network Open

Concussion Linked to Mental Health Issues Among Children Aged 5 to 18 Years – HealthDay

 

Guidelines on sickle cell disease: secondary stroke prevention in children and adolescents.

22 Mar, 2022 | 08:34h | UTC

Guidelines on sickle cell disease: secondary stroke prevention in children and adolescents. Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular guidelines project: Associação Médica Brasileira – 2022 – Hematology, Transfusion and Cell Therapy

Related: RCT: In children with sickle cell anemia, hydroxyurea in moderate doses (20 mg/kg per day) is not better than low doses (10 mg/kg per day) for primary stroke prevention.

 

Observational Study: Comparison of intracranial pressure measurements before and after hypertonic saline or mannitol treatment in children with severe traumatic brain injury.

14 Mar, 2022 | 00:51h | UTC

Comparison of Intracranial Pressure Measurements Before and After Hypertonic Saline or Mannitol Treatment in Children With Severe Traumatic Brain Injury – JAMA Network Open

Invited Commentary: ADAPTing to a New Era of Comparative Effectiveness Research in Traumatic Brain Injury—Generating Evidence From Observational Data – JAMA Network Open

 

Commentary on Twitter

 

Association of acute respiratory failure in early childhood with long-term neurocognitive outcomes.

9 Mar, 2022 | 08:41h | UTC

Association of Acute Respiratory Failure in Early Childhood With Long-term Neurocognitive Outcomes – JAMA (link to abstract – $ for full-text)

Commentaries:

IQ Lower for Survivors of PICU Respiratory Failure Hospitalization – HealthDay

Investigating The Effects of Critical Illness in Early Childhood On Neurocognitive Outcomes – University of Pennsylvania School of Nursing

 

Cohort Study: Association between screen time exposure in children at 1 year of age and autism spectrum disorder at 3 years of age.

4 Mar, 2022 | 09:54h | UTC

Association Between Screen Time Exposure in Children at 1 Year of Age and Autism Spectrum Disorder at 3 Years of Age: The Japan Environment and Children’s Study – JAMA Pediatrics

Commentary: Screen Time Linked to Autism Spectrum Disorder in Boys – HealthDay

Related:

M-A: Global prevalence of meeting screen time guidelines among children 5 years and younger.

Media and Young Minds – American Academy of Pediatrics

Guidelines on Screen Time and Digital Wellness in Infants, Children and Adolescents – “children below 2 years age should not be exposed to any type of screen, whereas exposure should be limited to a maximum of one hour of supervised screen time per day for children 24-59 months age, and less than two hours per day for children 5-10 years age”.

 

Mortality from congenital Zika Syndrome — nationwide cohort study in Brazil.

24 Feb, 2022 | 10:18h | UTC

Mortality from Congenital Zika Syndrome — Nationwide Cohort Study in Brazil – New England Journal of Medicine

 

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