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Oncology – Gynecologic

M-A of randomized trials | Hyperthermic intraperitoneal chemotherapy (HIPEC) for the management of primary advanced and recurrent ovarian cancer.

20 Sep, 2022 | 13:23h | UTC

Hyperthermic intraperitoneal chemotherapy (HIPEC) for the management of primary advanced and recurrent ovarian cancer: a systematic review and meta-analysis of randomized trials – ESMO Open

Related:

Survival After Hyperthermic Intraperitoneal Chemotherapy and Primary or Interval Cytoreductive Surgery in Ovarian Cancer: A Randomized Clinical Trial – JAMA Surgery

Hyperthermic Intraperitoneal Chemotherapy in Ovarian Cancer – New England Journal of Medicine

 


Systematic Review | Debulking hysterectomy followed by chemoradiotherapy vs. chemoradiotherapy alone for women with locally advanced cancer of the cervix – not enough evidence to guide recommendations.

19 Sep, 2022 | 12:39h | UTC

Debulking hysterectomy followed by chemoradiotherapy versus chemoradiotherapy for FIGO stage (2019) IB3/II cervical cancer – Cochrane Library

Summary: Debulking hysterectomy followed by chemoradiotherapy versus chemoradiotherapy for FIGO (2019) stage IB3/II cervical cancer – Cochrane Library

 


Systematic Review | Ultra‐radical (extensive) surgery vs. standard surgery for the primary cytoreduction of advanced epithelial ovarian cancer.

13 Sep, 2022 | 12:56h | UTC

Ultra‐radical (extensive) surgery versus standard surgery for the primary cytoreduction of advanced epithelial ovarian cancer – Cochrane Library

Summary: Ultra-radical (extensive) surgery versus standard surgery to remove tumours in women with advanced ovarian cancer – Cochrane Library

Related Study: Randomized Trial of Cytoreductive Surgery for Relapsed Ovarian Cancer – New England Journal of Medicine

 


Screening for high-risk human papillomavirus using passive, self-collected menstrual blood.

11 Sep, 2022 | 22:41h | UTC

Screening for High-Risk Human Papillomavirus Using Passive, Self-Collected Menstrual Blood – Obstetrics & Gynecology

Commentary: Pap smears, be gone? Using menstrual blood to detect HPV – Stanford Medicine

 

Commentary on Twitter

 


RCT | Overall survival with maintenance Olaparib at a 7-year follow-up in patients with newly diagnosed advanced ovarian cancer and a BRCA mutation.

11 Sep, 2022 | 22:21h | UTC

Overall Survival With Maintenance Olaparib at a 7-Year Follow-Up in Patients With Newly Diagnosed Advanced Ovarian Cancer and a BRCA Mutation: The SOLO1/GOG 3004 Trial – Journal of Clinical Oncology

Commentary: Olaparib Maintenance Provides Sustained OS Benefit in Newly Diagnosed, BRCA-Mutated, Advanced Ovarian Cancer – OncLive

 


A simple cervicovaginal epigenetic test for screening and rapid triage of women with suspected endometrial cancer: validation in several cohort and case/control sets.

29 Aug, 2022 | 11:58h | UTC

A Simple Cervicovaginal Epigenetic Test for Screening and Rapid Triage of Women With Suspected Endometrial Cancer: Validation in Several Cohort and Case/Control Sets – Journal of Clinical Oncology

 

Commentary on Twitter

Under a https://creativecommons.org/licenses/by/4.0/ license

 


RCT | HPV self-sampling among long-term non-attenders to cervical cancer screening.

26 Aug, 2022 | 13:27h | UTC

HPV self-sampling among long-term non-attenders to cervical cancer screening in Norway: a pragmatic randomised controlled trial – British Journal of Cancer

 

Commentary on Twitter

 


Endocervical sampling in women with suspected cervical neoplasia: a systematic review and meta-analysis of diagnostic test accuracy studies.

26 Aug, 2022 | 13:18h | UTC

Endocervical sampling in women with suspected cervical neoplasia: a systematic review and meta-analysis of diagnostic test accuracy studies – American Journal of Obstetrics & Gynecology

 


Systematic Review | Hysterectomy with radiotherapy or chemotherapy or both for women with locally advanced cervical cancer.

26 Aug, 2022 | 13:11h | UTC

Hysterectomy with radiotherapy or chemotherapy or both for women with locally advanced cervical cancer – Cochrane Library

Summary: Hysterectomy with medical management for cervical cancer that has spread to nearby tissues only – Cochrane Library

 


Observational study suggests frequent aspirin use may reduce the risk of ovarian cancer.

25 Aug, 2022 | 11:49h | UTC

Modification of the Association Between Frequent Aspirin Use and Ovarian Cancer Risk: A Meta-Analysis Using Individual-Level Data From Two Ovarian Cancer Consortia – Journal of Clinical Oncology (link to abstract – $ for full-text)

Commentaries:

Frequent Aspirin Use Tied to Lower Ovarian Cancer Risk – HealthDay

Frequent Aspirin Use Shows Promise for Preventing Ovarian Cancer in Individuals at Higher Risk – University of Utah

 

Commentary on Twitter

 


Long-term follow up of a RCT | Precancerous cervical lesions caused by non-vaccine-preventable HPV types after vaccination with the bivalent AS04-adjuvanted HPV vaccine.

24 Aug, 2022 | 13:53h | UTC

Precancerous cervical lesions caused by non-vaccine-preventable HPV types after vaccination with the bivalent AS04-adjuvanted HPV vaccine: an analysis of the long-term follow-up study from the randomised Costa Rica HPV Vaccine Trial – The Lancet Oncology (link to abstract – $ for full-text)

Commentary: Clinical Unmasking May Cause Increased Rates of High-Grade Cervical Neoplasia From Non–Vaccine Preventable HPV – Cancer Network

 

Commentary on Twitter

 


Systematic Review | Menopausal status, ultrasound and biomarker tests in combination for the diagnosis of ovarian cancer in symptomatic women.

17 Aug, 2022 | 14:12h | UTC

Menopausal status, ultrasound and biomarker tests in combination for the diagnosis of ovarian cancer in symptomatic women – Cochrane Library

Summary: What is the accuracy of different combinations of ultrasound imaging and blood tests to diagnose ovarian cancer in women before and after the menopause? – Cochrane Library

 


M-A | Role of human papillomavirus (HPV) vaccination on HPV infection and recurrence of HPV related disease after local surgical treatment.

5 Aug, 2022 | 14:43h | UTC

Role of human papillomavirus (HPV) vaccination on HPV infection and recurrence of HPV related disease after local surgical treatment: systematic review and meta-analysis – The BMJ

News Release: HPV vaccination alongside surgery for cervical lesions may reduce risk of further disease – BMJ Newsroom

 


Systematic Review | Endometrial cancer and BRCA mutations.

5 Aug, 2022 | 14:09h | UTC

Endometrial Cancer and BRCA Mutations: A Systematic Review – Journal of Clinical Medicine

 


Global trends and age-specific incidence and mortality of cervical cancer from 1990 to 2019: an international comparative study based on the Global Burden of Disease.

1 Aug, 2022 | 12:09h | UTC

Global trends and age-specific incidence and mortality of cervical cancer from 1990 to 2019: an international comparative study based on the Global Burden of Disease – BMJ Open

 


RCT | Effectiveness of intensive vs. minimalist follow-up regimen on survival in patients with endometrial cancer.

25 Jul, 2022 | 12:42h | UTC

Effectiveness of Intensive Versus Minimalist Follow-Up Regimen on Survival in Patients With Endometrial Cancer (TOTEM Study): A Randomized, Pragmatic, Parallel Group, Multicenter Trial – Journal of Clinical Oncology (link to abstract – $ for full-text)

 


Network M-A | Comparative effectiveness and risk of preterm birth of local treatments for cervical intraepithelial neoplasia and stage IA1 cervical cancer.

18 Jul, 2022 | 11:27h | UTC

Comparative effectiveness and risk of preterm birth of local treatments for cervical intraepithelial neoplasia and stage IA1 cervical cancer: a systematic review and network meta-analysis – The Lancet Oncology

 

Commentary on Twitter

 


Female erectile tissues and sexual dysfunction after pelvic radiotherapy: a scoping review.

13 Jul, 2022 | 11:23h | UTC

Female erectile tissues and sexual dysfunction after pelvic radiotherapy: A scoping review – CA: A Cancer Journal for Clinicians

 


RCT | Weekly dose-dense chemotherapy in first-line epithelial ovarian, fallopian tube, or primary peritoneal cancer treatment.

12 Jul, 2022 | 11:51h | UTC

Weekly dose-dense chemotherapy in first-line epithelial ovarian, fallopian tube, or primary peritoneal cancer treatment (ICON8): overall survival results from an open-label, randomised, controlled, phase 3 trial – The Lancet Oncology

 

Commentary on Twitter

 


RCT: Effect of Apatinib plus Pegylated Liposomal Doxorubicin vs. Pegylated Liposomal Doxorubicin alone on platinum-resistant recurrent ovarian cancer.

1 Jul, 2022 | 10:37h | UTC

Effect of Apatinib Plus Pegylated Liposomal Doxorubicin vs Pegylated Liposomal Doxorubicin Alone on Platinum-Resistant Recurrent Ovarian Cancer: The APPROVE Randomized Clinical Trial – JAMA Oncology

See also: Visual Abstract

 


RCT: Maintenance Taxanes vs. surveillance in women with advanced ovarian/tubal/peritoneal cancer.

29 Jun, 2022 | 10:57h | UTC

Phase III Randomized Trial of Maintenance Taxanes Versus Surveillance in Women With Advanced Ovarian/Tubal/Peritoneal Cancer: A Gynecologic Oncology Group 0212:NRG Oncology Study – Journal of Clinical Oncology (link to abstract – $ for full-text)

News Release: Additional taxane maintenance therapy does not successfully improve overall survival for women with advanced ovarian, peritoneal, and tubal cancers – NPR Oncology

 


Consensus Statement: First-line PARP inhibitor maintenance for advanced, high-grade serous and endometrioid tubal, ovarian, and primary peritoneal cancers.

27 Jun, 2022 | 11:34h | UTC

A Pan-Canadian Consensus Statement on First-Line PARP Inhibitor Maintenance for Advanced, High-Grade Serous and Endometrioid Tubal, Ovarian, and Primary Peritoneal Cancers – Current Oncology

 


International consensus statements on pre-invasive vulvar lesions.

23 Jun, 2022 | 10:21h | UTC

The European Society of Gynaecological Oncology (ESGO), the International Society for the Study of Vulvovaginal Disease (ISSVD), the European College for the Study of Vulval Disease (ECSVD) and the European Federation for Colposcopy (EFC) consensus statements on pre-invasive vulvar lesions – International Journal of Gynecological Cancer

News Release: New Guidelines Address Treatment of Pre-Invasive Lesions of the Vulva – Wolters Kluwer Health: Lippincott

 


ESMO Guideline: Diagnosis, treatment, and follow-up of endometrial cancer.

13 Jun, 2022 | 08:08h | UTC

Endometrial cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up – Annals of Oncology

 


Screening every five years safe for women who test negative for HPV, study confirms.

9 Jun, 2022 | 11:26h | UTC

News Release: Screening every five years safe for women who test negative for HPV, study confirms – King’s College London

Original Study: Extension of cervical screening intervals with primary human papillomavirus testing: observational study of English screening pilot data – The BMJ

Editorial: HPV screening for cervical cancer is reaching maturity – The BMJ

Related WHO Guidance:

News release: New recommendations for screening and treatment to prevent cervical cancer – World Health Organization

See guidance: WHO guideline for screening and treatment of cervical pre-cancer lesions for cervical cancer prevention – World Health Organization

Related USPSTF Guidance: Screening for Cervical Cancer: US Preventive Services Task Force Recommendation Statement – JAMA

 


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