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Transplantation (all articles)

RCT | Exploring the impact of total pancreatectomy with islet autotransplantation to reduce postoperative complications

8 Aug, 2023 | 13:25h | UTC

Total Pancreatectomy With Islet Autotransplantation as an Alternative to High-risk Pancreatojejunostomy After Pancreaticoduodenectomy: A Prospective Randomized Trial – Annals of Surgery

 


AAP Policy Statement | Pediatric organ donation and transplantation: across the care continuum

1 Aug, 2023 | 14:26h | UTC

Pediatric Organ Donation and Transplantation: Across the Care Continuum – Pediatrics

News Release: Policy underscores role of medical home in pediatric organ donation, transplantation – AAP News

Commentary: Pediatric Organ Donation and Transplantation: What Primary Care Providers and Families Should Know – AAP Journal Blog

 


Nonrandomized Controlled Trial | Long-term survival of 80% in selected colorectal cancer patients post liver transplant

1 Aug, 2023 | 14:20h | UTC

Long-Term Survival, Prognostic Factors, and Selection of Patients With Colorectal Cancer for Liver Transplant: A Nonrandomized Controlled Trial – JAMA Surgery (link to abstract – $ for full-text)

 

Commentary on Twitter

 


Study | Left ventricular dysfunction in brain-dead heart donors – incidence, reversibility, and implications

31 Jul, 2023 | 14:09h | UTC

Left Ventricular Dysfunction Associated With Brain Death: Results From the Donor Heart Study – Circulation (free for a limited period)

 


Cohort Study | Proton pump inhibitor use linked to increased fatigue in kidney transplant recipients

26 Jul, 2023 | 13:21h | UTC

Proton Pump Inhibitor Use, Fatigue, and Health-Related Quality of Life in Kidney Transplant Recipients: Results From the TransplantLines Biobank and Cohort Study – American Journal of Kidney Diseases

 

Commentary on Twitter

 


AHA Statement | Indications, evaluation, and outcomes for dual heart-kidney and heart-liver transplantation

14 Jul, 2023 | 12:51h | UTC

Dual-Organ Transplantation: Indications, Evaluation, and Outcomes for Heart-Kidney and Heart-Liver Transplantation: A Scientific Statement From the American Heart Association – Circulation

 


Guideline | Acute liver failure

10 Jul, 2023 | 13:59h | UTC

Acute Liver Failure Guidelines – The American Journal of Gastroenterology

Related:

EASL Clinical Practice Guidelines on acute-on-chronic liver failure – Journal of Hepatology

Guidelines for the management of adult acute and acute-on-chronic liver failure in the ICU

Acute-on-chronic liver failure: far to go—a review – Critical Care

 


Canadian Guidance | Deceased organ and tissue donation after medical assistance in dying

10 Jul, 2023 | 13:41h | UTC

Deceased organ and tissue donation after medical assistance in dying: 2023 updated guidance for policy – Canadian Medical Association Journal

Commentary: What happens to the organs of people who choose medically assisted deaths? – CTV News

 


RCT | Substituting saline with balanced crystalloid solution reduces delayed graft function in kidney transplantation

30 Jun, 2023 | 14:56h | UTC

Summary: The BEST-Fluids study was a pragmatic, multicentre, double-blind, randomized controlled trial carried out across 16 hospitals in Australia and New Zealand, aimed at comparing the use of balanced crystalloid solution (Plasma-Lyte 148) and saline in deceased donor kidney transplantation. The sample size comprised of 808 participants, who were either adults or children of any age, with the primary outcome defined as delayed graft function (DGF) occurring within 7 days post-transplantation.

Findings from the trial revealed that the balanced crystalloid group experienced less DGF than the saline group, with 121 out of 404 participants (30%) and 160 out of 403 participants (40%), respectively. This result yields an adjusted relative risk of 0.74 and an adjusted risk difference of 10.1%.

The study suggests that balanced crystalloid solution significantly reduces the incidence of DGF compared to saline. As no significant safety concerns were raised during the trial, the researchers recommend the use of balanced crystalloid solution as the standard-of-care intravenous fluid in deceased donor kidney transplantation. However, the study doesn’t indicate any significant differences in graft failure or mortality rates, which calls for further research.

Article: Balanced crystalloid solution versus saline in deceased donor kidney transplantation (BEST-Fluids): a pragmatic, double-blind, randomised, controlled trial – The Lancet (free registration required)

 


Liver Transplantation 2023 | Status report, current and future challenges

29 Jun, 2023 | 13:50h | UTC

Liver Transplantation 2023: Status Report, Current and Future Challenges – Clinical Gastroenterology and Hepatology

 


RCT | Cyclophosphamide-based regimen enhances GVHD-free survival after hematopoietic stem-cell transplantation

27 Jun, 2023 | 13:54h | UTC

Summary: The article details a phase 3 trial comparing the efficacy of two graft-versus-host disease (GVHD) prophylactic regimens in hematologic cancer patients undergoing allogeneic hematopoietic stem-cell transplantation (HSCT). The experimental group received cyclophosphamide–tacrolimus–mycophenolate mofetil, and the standard group received tacrolimus–methotrexate. The patients, a total of 431, underwent HSCT from an HLA-matched related donor or a matched or 7/8 mismatched unrelated donor.

The primary end point was GVHD-free, relapse-free survival at 1 year. Results indicated a significantly higher incidence of this outcome in the experimental group (hazard ratio, 0.64; 95% confidence interval [CI], 0.49 to 0.83; P=0.001). At 1 year, adjusted GVHD-free, relapse-free survival was 52.7% (95% CI, 45.8 to 59.2) in the experimental group, compared to 34.9% (95% CI, 28.6 to 41.3) in the standard group.

Notably, patients in the experimental-prophylaxis group appeared to have less severe acute or chronic GVHD and a higher incidence of immunosuppression-free survival at 1 year. Overall survival, disease-free survival, relapse, transplantation-related death, and engraftment did not show a substantial difference between the groups. These results suggest that cyclophosphamide–tacrolimus–mycophenolate mofetil may offer a more effective prophylaxis against GVHD in HSCT patients.

Article: Post-Transplantation Cyclophosphamide-Based Graft-versus-Host Disease Prophylaxis – New England Journal of Medicine (link to abstract – $ for full-text)

News Release: Study Sets New Standard for Graft-Versus-Host Disease Prevention After Stem Cell Transplant – Johns Hopkins Medicine

 

Commentary on Twitter

 


Consensus Paper | Primary prophylaxis of invasive fungal diseases in patients with hematological malignancies

23 Jun, 2023 | 13:23h | UTC

Primary prophylaxis of invasive fungal diseases in patients with haematological malignancies: 2022 update of the recommendations of the Infectious Diseases Working Party (AGIHO) of the German Society for Haematology and Medical Oncology (DGHO) – Journal of Antimicrobial Chemotherapy

 


Review | Acute graft-versus-host disease

14 Jun, 2023 | 14:20h | UTC

Acute graft-versus-host disease – Nature Reviews Disease Primers (if the link is paywalled, try this one)

 

Commentary on Twitter

 


RCT | No change in delayed graft function with normothermic perfusion vs. cold storage in kidney transplants

13 Jun, 2023 | 14:00h | UTC

Normothermic machine perfusion versus static cold storage in donation after circulatory death kidney transplantation: a randomized controlled trial – Nature Medicine

 

Commentary on Twitter

 


Review | Challenges and opportunities in antimicrobial stewardship among hematopoietic stem cell transplant and oncology patients

13 Jun, 2023 | 13:55h | UTC

Challenges and Opportunities in Antimicrobial Stewardship among Hematopoietic Stem Cell Transplant and Oncology Patients – Antibiotics

 


RCT | Noninferior survival rates with hearts donated after circulatory death versus brain death

12 Jun, 2023 | 13:57h | UTC

Transplantation Outcomes with Donor Hearts after Circulatory Death – New England Journal of Medicine (link to abstract – $ for full-text)

Video summary: Outcomes with Donor Hearts after Circulatory Death | NEJM

News Release: Multicenter Trial Finds Using Circulatory Death Donors is Safe and Effective for Heart Transplantation – Northwestern Medicine

Commentary: Transplantation Outcomes With Donor Hearts After Circulatory Death – American College of Cardiology

 

Commentary on Twitter

 


RCT | Letermovir demonstrates noninferiority to valganciclovir for CMV prophylaxis in kidney transplantation

12 Jun, 2023 | 13:38h | UTC

Letermovir vs Valganciclovir for Prophylaxis of Cytomegalovirus in High-Risk Kidney Transplant Recipients: A Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: A New Antiviral Option for Cytomegalovirus Prevention After Kidney Transplant – JAMA (free for a limited period)

See also: Visual Abstract

Commentary: Newly approved antiviral is promising alternative against cytomegalovirus illness in kidney transplants – CIDRAP

 


Consensus Paper | Organ donation in the surgical ICU

1 Jun, 2023 | 12:12h | UTC

Organ donation in the surgical ICU: an American Association for the Surgery of Trauma Critical Care Committee clinical consensus document – Trauma Surgery & Acute Care Open

 


ISHLT Guideline | Mechanical circulatory support

29 May, 2023 | 10:40h | UTC

The 2023 International Society for Heart and Lung Transplantation Guidelines for Mechanical Circulatory Support: A 10- Year Update – The Journal of Heart and Lung Transplantation

 


ISHLT Guidelines for the care of heart transplant recipients

3 May, 2023 | 15:09h | UTC

The International Society for Heart and Lung Transplantation (ISHLT) guidelines for the care of heart transplant recipients – The Journal of Heart and Lung Transplantation

 


Extracorporeal CPR dissemination and integration with organ preservation in the USA: ethical and logistical considerations

28 Apr, 2023 | 12:47h | UTC

Extracorporeal cardiopulmonary resuscitation dissemination and integration with organ preservation in the USA: ethical and logistical considerations – Critical Care

 


Perspective | Liver transplantation for patients with severe acute on chronic liver failure: it is time to change paradigms

25 Apr, 2023 | 14:37h | UTC

Liver transplantation for patients with severe acute on chronic liver failure: it is time to change paradigms – Intensive Care Medicine

 

Commentary on Twitter

 


Cold static preservation at 10°C shows promising results for safely extending lung transplantation timeframes

24 Apr, 2023 | 13:38h | UTC

Extension of Cold Static Donor Lung Preservation at 10°C – NEJM Evidence

 

Commentary on Twitter

 


Guidelines for the management of adult acute and acute-on-chronic liver failure in the ICU

17 Apr, 2023 | 13:19h | UTC

Guidelines for the Management of Adult Acute and Acute-on-Chronic Liver Failure in the ICU: Neurology, Peri-Transplant Medicine, Infectious Disease, and Gastroenterology Considerations – Critical Care Medicine (free for a limited period)

Executive Summary: Guidelines for the Management of Adult Acute and Acute-on-Chronic Liver Failure in the ICU: Neurology, Peri-Transplant Medicine, Infectious Disease, and Gastroenterology Considerations – Critical Care Medicine (free for a limited period)

 


Overcoming size disparity in liver transplant access: prioritizing smaller donors for smaller candidates

3 Apr, 2023 | 13:41h | UTC

Association of Body Surface Area With Access to Deceased Donor Liver Transplant and Novel Allocation Policies – JAMA Surgery (free for a limited period)

Invited Commentary: Addressing Size-Based Disparities in Liver Transplant – JAMA Surgery (free for a limited period)

 

Commentary on Twitter

 


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