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Transplantation (all articles)

Expanding Organ Usage: UK study finds organs from patients with a primary brain tumor are a viable option

27 Mar, 2023 | 13:27h | UTC

Summary: A national cohort study in the UK investigated the risk of cancer transmission from deceased donors with primary brain tumors to organ recipients. The study found no cases of brain tumor transmission among 778 transplants from 282 donors with primary brain tumors, including 262 from donors with high-grade tumors. Organ transplant survival was equivalent to that in matched controls, and some organs from donors with high-grade tumors were less likely to be transplanted.

The results suggest that the risk of cancer transmission in transplants from deceased donors with primary brain tumors is lower than previously thought. Furthermore, the study indicated that donors with brain tumors provided good-quality organs with favorable risk markers and excellent transplant outcomes. Some organs from donors with high-grade tumors were underutilized, indicating a possible aversion by transplant clinicians or patients to use these organs.

These findings imply that it may be possible to safely expand organ usage from donors with primary brain tumors without negatively impacting outcomes, potentially benefiting many patients waiting for a transplant. Although this might lead to a slight rise in transplant numbers in the UK, the findings may hold particular significance for nations with stricter guidelines, such as the United States. The study’s findings can help transplant clinicians discuss the risks and benefits of accepting organ offers from such donors.

Article: Organ Transplants From Deceased Donors With Primary Brain Tumors and Risk of Cancer Transmission – JAMA Surgery

 


Review | Lung transplantation for COPD/pulmonary emphysema

27 Mar, 2023 | 12:58h | UTC

Lung transplantation for COPD/pulmonary emphysema – European Respiratory Review

 


ISCCM Position Statement | Recommendations for evaluation and selection of deceased organ donor

13 Mar, 2023 | 14:50h | UTC

Recommendations for Evaluation and Selection of Deceased Organ Donor: Position Statement of ISCCM – Indian Journal of Critical Care Medicine

 


DNA sequencing may identify an increased risk of relapse in adults with AML prior to hematopoietic cell transplantation

13 Mar, 2023 | 14:47h | UTC

DNA Sequencing to Detect Residual Disease in Adults With Acute Myeloid Leukemia Prior to Hematopoietic Cell Transplant – JAMA (free for a limited period)

News Release: Blood test identifies acute myeloid leukemia patients at greater risk for relapse after bone marrow transplant – National Institutes of Health

Commentary: Blood Test May Identify Patients With AML at Greater Risk of Relapse After Bone Marrow Transplant – The ASCO Post

 

Commentary on Twitter

 


Registry of the international society of uterus transplantation: first report

24 Feb, 2023 | 13:29h | UTC

Registry of the International Society of Uterus Transplantation: First Report – Transplantation

 


Current status of liver transplantation for non-B non-C liver cirrhosis and hepatocellular carcinoma

17 Feb, 2023 | 12:36h | UTC

Current status of liver transplantation for non-B non-C liver cirrhosis and hepatocellular carcinoma – Annals of Gastroenterological Surgery

 


Review | Management of adult patients with hematological malignancies in critical care

10 Feb, 2023 | 13:45h | UTC

Management of adult patients with haematological malignancies in critical care – Anaesthesia

 


RCT | Machine perfusion is superior to therapeutic hypothermia for reducing delayed graft function after kidney transplantation

6 Feb, 2023 | 13:28h | UTC

Hypothermia or Machine Perfusion in Kidney Donors – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Machine Perfusion of Kidneys Protects Against Delayed Graft Function – HealthDay

 

Commentary with video on Twitter

 


Post-transplant biliary complications: advances in pathophysiology, diagnosis, and treatment

3 Feb, 2023 | 14:01h | UTC

Post-transplant biliary complications: advances in pathophysiology, diagnosis, and treatment – BMJ Open Gastroenterology

 


Cohort Study | Risk of malignant neoplasms of the gastrointestinal tract after blood or marrow transplant

30 Jan, 2023 | 00:23h | UTC

Malignant Neoplasms of the Gastrointestinal Tract After Blood or Marrow Transplant – JAMA Oncology (link to abstract – $ for full-text)

Commentary: Risk of Subsequent Gastrointestinal Tract Malignancies After Blood or Marrow Transplantation – The ASCO Post

 

Commentary on Twitter

 


RCT | Sodium bicarbonate over 2 years was not beneficial for kidney transplant recipients with metabolic acidosis

27 Jan, 2023 | 12:23h | UTC

Sodium bicarbonate for kidney transplant recipients with metabolic acidosis in Switzerland: a multicentre, randomised, single-blind, placebo-controlled, phase 3 trial – The Lancet (link to abstract – $ for full-text)

 


ASCO Guideline | Management of fever and neutropenia in pediatric patients with cancer and hematopoietic cell transplantation recipients

24 Jan, 2023 | 14:28h | UTC

Guideline for the Management of Fever and Neutropenia in Pediatric Patients With Cancer and Hematopoietic Cell Transplantation Recipients: 2023 Update – Journal of Clinical Oncology

 


Guidelines | Enhanced recovery after surgery recommendations for renal transplantation

20 Jan, 2023 | 14:51h | UTC

Enhanced recovery after surgery recommendations for renal transplantation: guidelines – British Journal of Surgery

Related:

Complete List of Enhanced Recovery After Surgery (ERAS) Society Guidelines

Top 100 Most-Cited Articles on Enhanced Recovery After Surgery: A Bibliometric Analysis and Visualized Study – Frontiers in Surgery

 

Commentary on Twitter

 


An investigational T-cell therapy shows promise against six viral infections common after stem cell transplants

13 Jan, 2023 | 13:10h | UTC

News Release: An investigational T-cell therapy shows promise against six viral infections common after stem cell transplants – American Association for Cancer Research

Original Article: Posoleucel, an Allogeneic, Off-the-Shelf Multivirus-Specific T-Cell Therapy, for the Treatment of Refractory Viral Infections in the Post-HCT Setting – Clinical Cancer Research

Commentary: Study Finds Posoleucel Demonstrated Antiviral Efficacy and Safety Against Viral Infections Following Allogeneic Stem Cell Transplantation – The ASCO Post

 


Consensus Document | The use of mechanical circulatory support in lung transplantation

11 Jan, 2023 | 14:18h | UTC

The American Association for Thoracic Surgery (AATS) 2022 Expert Consensus Document: The use of mechanical circulatory support in lung transplantation – The Journal of Thoracic and Cardiovascular Surgery

 

Commentary on Twitter

 


Recommendations for living donor kidney transplantation

10 Jan, 2023 | 14:39h | UTC

Recommendations for living donor kidney transplantation – Nefrología

 


Guidance on developing and/or expanding pediatric solid organ transplantation programs in low- and middle-income countries.

6 Dec, 2022 | 13:47h | UTC

International pediatric transplant association (IPTA) guidance on developing and/or expanding pediatric solid organ transplantation programs in low- and middle-income countries – Pediatric Transplantation

 


Joint consensus statement on the vaccination of adult and pediatric hematopoietic stem cell transplant recipients.

30 Nov, 2022 | 13:39h | UTC

Joint consensus statement on the vaccination of adult and paediatric haematopoietic stem cell transplant recipients: Prepared on behalf of the British society of blood and marrow transplantation and cellular therapy (BSBMTCT), the Children’s cancer and Leukaemia Group (CCLG), and British Infection Association (BIA) – Journal of Infection

 


Consensus Paper | Hematopoietic cell transplantation in the management of myelodysplastic syndrome.

29 Nov, 2022 | 14:11h | UTC

Hematopoietic Cell Transplantation in the Management of Myelodysplastic Syndrome: An Evidence-Based Review from the ASTCT Committee on Practice Guidelines – Transplantation and Cellular Therapy

 


Review | Long-term medical outcomes of living kidney donors.

27 Nov, 2022 | 22:04h | UTC

Long-term Medical Outcomes of Living Kidney Donors – Mayo Clinic Proceedings

 


Skin cancer in solid organ transplant recipients: a review for the non-dermatologist.

27 Nov, 2022 | 22:02h | UTC

Skin Cancer in Solid Organ Transplant Recipients: A Review for the Nondermatologist – Mayo Clinic Proceedings

 


Expert consensus on liver transplantation perioperative evaluation and rehabilitation for acute-on-chronic liver failure.

21 Nov, 2022 | 14:21h | UTC

Expert consensus on liver transplantation perioperative evaluation and rehabilitation for acute-on-chronic liver failure – Liver Research 

 


Special Issue | Lung transplantation.

10 Nov, 2022 | 13:30h | UTC

Homepage

Indications for Lung Transplantation and Patient Selection

Recipient Management before Lung Transplantation

Allocation of Donor Lungs in Korea

Donor Selection, Management, and Procurement for Lung Transplantation

Donation after Circulatory Death in Lung Transplantation

Ex Vivo Lung Perfusion in Lung Transplantatio

A Review of Anesthesia for Lung Transplantation

Technical Aspects of Lung Transplantation: General Considerations

Technical Aspects of Lung Transplantation: Adverse Events and Circumstances

Technical Aspects of Lung Transplantation: Pediatric and Lobar Transplantation

Technical Aspects of Combined Heart-Lung Transplantation

Critical Care Management Following Lung Transplantation

Surgical Complications Affecting the Early and Late Survival Rates after Lung Transplantation

Medical Complications of Lung Transplantation

Lung Transplantation for Patients with COVID-19 Acute Respiratory Distress Syndrome

 


SR | Pregnancy after living kidney donation.

8 Nov, 2022 | 11:56h | UTC

Pregnancy after living kidney donation, a systematic review of the available evidence, and a review of the current guidance – American Journal of Transplantation

Video: Pregnancy after living kidney donation, a review of the available evidence and current guidance

 


Review | Determining prognosis of alcoholic liver disease and alcoholic hepatitis.

4 Nov, 2022 | 13:17h | UTC

Determining Prognosis of ALD and Alcoholic Hepatitis – Journal of Clinical and Experimental Hepatology 

 


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