Transplantation (all articles)
Expanding Organ Usage: UK study finds organs from patients with a primary brain tumor are a viable option
27 Mar, 2023 | 13:27h | UTCSummary: A national cohort study in the UK investigated the risk of cancer transmission from deceased donors with primary brain tumors to organ recipients. The study found no cases of brain tumor transmission among 778 transplants from 282 donors with primary brain tumors, including 262 from donors with high-grade tumors. Organ transplant survival was equivalent to that in matched controls, and some organs from donors with high-grade tumors were less likely to be transplanted.
The results suggest that the risk of cancer transmission in transplants from deceased donors with primary brain tumors is lower than previously thought. Furthermore, the study indicated that donors with brain tumors provided good-quality organs with favorable risk markers and excellent transplant outcomes. Some organs from donors with high-grade tumors were underutilized, indicating a possible aversion by transplant clinicians or patients to use these organs.
These findings imply that it may be possible to safely expand organ usage from donors with primary brain tumors without negatively impacting outcomes, potentially benefiting many patients waiting for a transplant. Although this might lead to a slight rise in transplant numbers in the UK, the findings may hold particular significance for nations with stricter guidelines, such as the United States. The study’s findings can help transplant clinicians discuss the risks and benefits of accepting organ offers from such donors.
Review | Lung transplantation for COPD/pulmonary emphysema
27 Mar, 2023 | 12:58h | UTCLung transplantation for COPD/pulmonary emphysema – European Respiratory Review
ISCCM Position Statement | Recommendations for evaluation and selection of deceased organ donor
13 Mar, 2023 | 14:50h | UTC
DNA sequencing may identify an increased risk of relapse in adults with AML prior to hematopoietic cell transplantation
13 Mar, 2023 | 14:47h | UTCDNA Sequencing to Detect Residual Disease in Adults With Acute Myeloid Leukemia Prior to Hematopoietic Cell Transplant – JAMA (free for a limited period)
Commentary on Twitter
Among patients w AML in first remission prior to allogeneic hematopoietic cell transplant, the persistence of residual variants in the blood at an allele fraction ≥0.01% was assoc'd w increased relapse & worse survival vs those w/o these variants. https://t.co/KCnaQ1NRXJ
— JAMA (@JAMA_current) March 11, 2023
Registry of the international society of uterus transplantation: first report
24 Feb, 2023 | 13:29h | UTCRegistry of the International Society of Uterus Transplantation: First Report – Transplantation
Current status of liver transplantation for non-B non-C liver cirrhosis and hepatocellular carcinoma
17 Feb, 2023 | 12:36h | UTC
Review | Management of adult patients with hematological malignancies in critical care
10 Feb, 2023 | 13:45h | UTCManagement of adult patients with haematological malignancies in critical care – Anaesthesia
RCT | Machine perfusion is superior to therapeutic hypothermia for reducing delayed graft function after kidney transplantation
6 Feb, 2023 | 13:28h | UTCHypothermia or Machine Perfusion in Kidney Donors – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Machine Perfusion of Kidneys Protects Against Delayed Graft Function – HealthDay
Commentary with video on Twitter
Hypothermia of brain-dead kidney donors and machine perfusion of the kidney can reduce delayed graft function, but whether hypothermia is as effective as machine perfusion is unclear. New research findings are summarized in a short video. https://t.co/mL0YQZYoK1 pic.twitter.com/ANnJl27mkl
— NEJM (@NEJM) February 4, 2023
Post-transplant biliary complications: advances in pathophysiology, diagnosis, and treatment
3 Feb, 2023 | 14:01h | UTC
Cohort Study | Risk of malignant neoplasms of the gastrointestinal tract after blood or marrow transplant
30 Jan, 2023 | 00:23h | UTCMalignant Neoplasms of the Gastrointestinal Tract After Blood or Marrow Transplant – JAMA Oncology (link to abstract – $ for full-text)
Commentary: Risk of Subsequent Gastrointestinal Tract Malignancies After Blood or Marrow Transplantation – The ASCO Post
Commentary on Twitter
Exposure to cytarabine, etoposide and anthracyclines & chronic graft vs. host disease increase risk of colorectal, liver & esophageal cancer after BMT, providing evidence for appropriate evaluation & management in high-risk populations. https://t.co/UENFM1UWRw
— JAMA Oncology (@JAMAOnc) January 23, 2023
RCT | Sodium bicarbonate over 2 years was not beneficial for kidney transplant recipients with metabolic acidosis
27 Jan, 2023 | 12:23h | UTCSodium bicarbonate for kidney transplant recipients with metabolic acidosis in Switzerland: a multicentre, randomised, single-blind, placebo-controlled, phase 3 trial – The Lancet (link to abstract – $ for full-text)
ASCO Guideline | Management of fever and neutropenia in pediatric patients with cancer and hematopoietic cell transplantation recipients
24 Jan, 2023 | 14:28h | UTC
Guidelines | Enhanced recovery after surgery recommendations for renal transplantation
20 Jan, 2023 | 14:51h | UTCRelated:
Complete List of Enhanced Recovery After Surgery (ERAS) Society Guidelines
Commentary on Twitter
Free to access in January's BJS: Enhanced recovery after surgery recommendations for renal transplantation: guidelines https://t.co/VkTRQmDWRS @bplwijn @des_winter @ksoreide @MalinASund @evanscolorectal @nfmkok @paulo_sutt @robhinchliffe1 @young_bjs pic.twitter.com/7JQYrlZJnO
— BJS (@BJSurgery) December 30, 2022
An investigational T-cell therapy shows promise against six viral infections common after stem cell transplants
13 Jan, 2023 | 13:10h | UTC
Consensus Document | The use of mechanical circulatory support in lung transplantation
11 Jan, 2023 | 14:18h | UTC
Commentary on Twitter
AATS announces the publication of “The use of mechanical circulatory support in lung transplantation" in #JTCVS! Read the AATS 2022 Expert Consensus Document: https://t.co/rNPCl6bzYK @mghartwigmd @AnkitBharatMD @MarceloCypel @KHoetzenecker @Machuca_TN @IsaOpitz @tssmn @AATSHQ pic.twitter.com/jU7JcJ0jeB
— AATS Journals (@AATSJournals) October 27, 2022
Recommendations for living donor kidney transplantation
10 Jan, 2023 | 14:39h | UTCRecommendations for living donor kidney transplantation – Nefrología
Guidance on developing and/or expanding pediatric solid organ transplantation programs in low- and middle-income countries.
6 Dec, 2022 | 13:47h | UTC
Joint consensus statement on the vaccination of adult and pediatric hematopoietic stem cell transplant recipients.
30 Nov, 2022 | 13:39h | UTC
Consensus Paper | Hematopoietic cell transplantation in the management of myelodysplastic syndrome.
29 Nov, 2022 | 14:11h | UTC
Review | Long-term medical outcomes of living kidney donors.
27 Nov, 2022 | 22:04h | UTCLong-term Medical Outcomes of Living Kidney Donors – Mayo Clinic Proceedings
Skin cancer in solid organ transplant recipients: a review for the non-dermatologist.
27 Nov, 2022 | 22:02h | UTC
Expert consensus on liver transplantation perioperative evaluation and rehabilitation for acute-on-chronic liver failure.
21 Nov, 2022 | 14:21h | UTC
Special Issue | Lung transplantation.
10 Nov, 2022 | 13:30h | UTCIndications for Lung Transplantation and Patient Selection
Recipient Management before Lung Transplantation
Allocation of Donor Lungs in Korea
Donor Selection, Management, and Procurement for Lung Transplantation
Donation after Circulatory Death in Lung Transplantation
Ex Vivo Lung Perfusion in Lung Transplantatio
A Review of Anesthesia for Lung Transplantation
Technical Aspects of Lung Transplantation: General Considerations
Technical Aspects of Lung Transplantation: Adverse Events and Circumstances
Technical Aspects of Lung Transplantation: Pediatric and Lobar Transplantation
Technical Aspects of Combined Heart-Lung Transplantation
Critical Care Management Following Lung Transplantation
Surgical Complications Affecting the Early and Late Survival Rates after Lung Transplantation
Medical Complications of Lung Transplantation
Lung Transplantation for Patients with COVID-19 Acute Respiratory Distress Syndrome
SR | Pregnancy after living kidney donation.
8 Nov, 2022 | 11:56h | UTCVideo: Pregnancy after living kidney donation, a review of the available evidence and current guidance
Review | Determining prognosis of alcoholic liver disease and alcoholic hepatitis.
4 Nov, 2022 | 13:17h | UTC