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Gastroenterology

RCT | Fecal microbiota transplantation better than standard of care for first or second Clostridioides difficile infection.

26 Sep, 2022 | 12:08h | UTC

Faecal microbiota transplantation for first or second Clostridioides difficile infection (EarlyFMT): a randomised, double-blind, placebo-controlled trial – The Lancet Gastroenterology & Hepatology (link to abstract – $ for full-text)

Commentary: New FMT Trial Halted Due to Effectiveness – HCP Live

 

Commentary from the author on Twitter (thread – click for more)

 

Expert Practical Guidance | Functional abdominal cramping pain.

26 Sep, 2022 | 12:05h | UTC

Functional Abdominal Cramping Pain: Expert Practical Guidance – Journal of Clinical Gastroenterology

 

M-A of the association between new hypoglycemic agents and digestive diseases.

22 Sep, 2022 | 13:16h | UTC

Meta-analysis of the association between new hypoglycemic agents and digestive diseases – Medicine

Commentary: Spotlight on digestive risks of newer diabetes drugs – ACP Gastroenterology

 

Review | Adrenal insufficiency in cirrhosis.

22 Sep, 2022 | 12:59h | UTC

Adrenal Insufficiency in Cirrhosis – Journal of the Endocrine Society

 

Patient Preference RCT | Short-term anti-TNF therapy with surgical closure vs. anti-TNF therapy alone in the treatment of perianal fistulas in Crohn’s disease.

21 Sep, 2022 | 13:09h | UTC

Short-term anti-TNF therapy with surgical closure versus anti-TNF therapy in the treatment of perianal fistulas in Crohn’s disease (PISA-II): a patient preference randomised trial – The Lancet Gastroenterology & Hepatology (link to abstract – $ for full-text)

Podcast: Elise Meima-van Praag on surgical closure for Crohn’s disease perianal fistulas

Commentary: Anti-TNF, surgical closure induces long-term healing in Crohn’s fistulas – Healio (free registration required)

 

Commentary on Twitter

 

Preliminary results of a RCT | Once-only colonoscopy vs. two rounds of fecal immunochemical testing 2 years apart for colorectal cancer screening.

20 Sep, 2022 | 13:29h | UTC

Once-only colonoscopy or two rounds of faecal immunochemical testing 2 years apart for colorectal cancer screening (SCREESCO): preliminary report of a randomised controlled trial – The Lancet Gastroenterology & Hepatology (link to abstract – $ for full-text)

Commentary: Two Rounds of FIT vs Single Colonoscopy as a One-time CRC Screening – Medscape (free registration required)

 

Diet and irritable bowel syndrome: an update from a UK consensus meeting.

19 Sep, 2022 | 12:42h | UTC

Diet and irritable bowel syndrome: an update from a UK consensus meeting – BMC Medicine

Related:

M-A | Efficacy of a restrictive diet in irritable bowel syndrome.

Diet or medication in primary care patients with IBS: the DOMINO study – a randomised trial supported by the Belgian Health Care Knowledge Centre (KCE Trials Programme) and the Rome Foundation Research Institute – Gut

AGA Clinical Practice Update on the Role of Diet in Irritable Bowel Syndrome: Expert Review – Gastroenterology

RCT: Efficacy and acceptability of dietary therapies in non-constipated irritable bowel syndrome: a randomized trial of traditional dietary advice, the low FODMAP diet and the gluten-free diet.

10 mistakes in dietary management of irritable bowel syndrome and how to avoid them.

Supplement: Irritable bowel syndrome and related conditions.

RCT: FODMAPs, but not gluten, elicit modest symptoms of irritable bowel syndrome.

RCT: Among patients with diarrhea-predominant irritable bowel syndrome, a low FODMAP diet achieved earlier symptomatic improvements in stool frequency and excessive wind.

British Society of Gastroenterology guidelines on the management of irritable bowel syndrome

Guidelines for the treatment of irritable bowel syndrome

ACG Clinical Guideline: Management of irritable bowel syndrome

M-A: Efficacy of a low-FODMAP diet in adult irritable bowel syndrome

 

M-A of randomized trials | Ondansetron vs. Metoclopramide for managing hyperemesis gravidarum.

19 Sep, 2022 | 12:34h | UTC

Ondansetron versus metoclopramide for managing hyperemesis gravidarum: A systematic review and meta-analysis of randomized controlled trials – Turkish Journal of Obstetrics and Gynecology

Commentary: Ondansetron or metoclopramide, which is better for managing hyperemesis gravidarum? – Medical Dialogues

 

The risk of subsequent surgery following bowel resection for Crohn’s disease in a national cohort of 19,207 patients.

19 Sep, 2022 | 12:33h | UTC

The risk of subsequent surgery following bowel resection for Crohn’s disease in a national cohort of 19,207 patients – Colorectal Disease (link to abstract – $ for full-text)

Commentary: Investigators Assess Risk of Further Surgery for Crohn’s Disease Patients – HCPLive

 

Nutrition assessment and management in patients with cirrhosis and cognitive impairment: a comprehensive review of literature.

19 Sep, 2022 | 12:29h | UTC

Nutrition Assessment and Management in Patients with Cirrhosis and Cognitive Impairment: A Comprehensive Review of Literature – Journal of Clinical Medicine

Commentary: Review Outlines Nutrition Assessment, Management in Patients With Cirrhosis – AJMC

 

Update | Management of hepatorenal syndrome in liver cirrhosis.

19 Sep, 2022 | 12:27h | UTC

Management of hepatorenal syndrome in liver cirrhosis: a recent update – Therapeutic Advances in Gastroenterology

 

German guidelines on non-alcoholic fatty liver disease.

15 Sep, 2022 | 13:07h | UTC

Updated S2k Clinical Practice Guideline on Non-alcoholic Fatty Liver Disease (NAFLD) issued by the German Society of Gastroenterology, Digestive and Metabolic Diseases (DGVS) – Zeitschrift für Gastroenterologie

Related:

AGA Clinical Practice Update | Diagnosis and management of nonalcoholic fatty liver disease in lean individuals.

Quality standards for the management of non-alcoholic fatty liver disease (NAFLD): consensus recommendations from the British Association for the Study of the Liver and British Society of Gastroenterology NAFLD Special Interest Group – The Lancet Gastroenterology & Hepatology (free registration required)

Nonalcoholic Fatty Liver Disease and Cardiovascular Risk: A Scientific Statement From the American Heart Association – Arteriosclerosis, Thrombosis, and Vascular Biology

Advancing the global public health agenda for NAFLD: a consensus statement – Nature Reviews Gastroenterology & Hepatology

Clinical Care Pathway for the Risk Stratification and Management of Patients With Nonalcoholic Fatty Liver Disease – Gastroenterology

Non-alcoholic fatty liver disease: A patient guideline – JHEP Reports

 

Long-term follow-up of a RCT | Endoscopic versus surgical step-up approach for infected necrotizing pancreatitis.

14 Sep, 2022 | 13:13h | UTC

Endoscopic Versus Surgical Step-Up Approach for Infected Necrotizing Pancreatitis (ExTENSION): Long-term Follow-up of a Randomized Trial – Gastroenterology

 

Commentary on Twitter

Under a Creative Commons Attribution (CC BY 4.0) License

 

Artificial liver support in patients with liver failure: a modified DELPHI consensus of international experts.

13 Sep, 2022 | 13:13h | UTC

Artificial liver support in patients with liver failure: a modified DELPHI consensus of international experts – Intensive Care Medicine

 

Commentary on Twitter

 

AGA Clinical practice update on the endoscopic approach to recurrent acute and chronic pancreatitis.

13 Sep, 2022 | 13:12h | UTC

AGA Clinical Practice Update on the Endoscopic Approach to Recurrent Acute and Chronic Pancreatitis: Expert Review – Gastroenterology

Commentary: AGA Clinical Practice Update: Expert review on endoscopic management for recurrent acute and chronic pancreatitis – MDedge

 

Review | Acute pancreatitis: diagnosis and treatment.

13 Sep, 2022 | 13:04h | UTC

Acute Pancreatitis: Diagnosis and Treatment – Drugs

Commentaries:

Revised Clinical Practice Guidelines of the Korean Pancreatobiliary Association for Acute Pancreatitis – Gut and Liver

Guidelines for the management of patients with severe acute pancreatitis, 2021 – Anaesthesia Critical Care & Pain Medicine

Evidence-Based Disposition of Acute Pancreatitis – emDocs

2019 WSES guidelines for the management of severe acute pancreatitis – World Journal of Emergency Surgery

American Gastroenterological Association Institute Guideline on Initial Management of Acute Pancreatitis

Pancreatitis – National Institute for Health and Care Excellence

 

Phase 2b RCT | ABX464 (obefazimod) for moderate-to-severe, active ulcerative colitis.

13 Sep, 2022 | 13:01h | UTC

ABX464 (obefazimod) for moderate-to-severe, active ulcerative colitis: a phase 2b, double-blind, randomised, placebo-controlled induction trial and 48 week, open-label extension – The Lancet Gastroenterology & Hepatology (link to abstract – $ for full-text)

 

Commentary on Twitter

 

M-A | Combination therapy with rifaximin and lactulose in hepatic encephalopathy.

11 Sep, 2022 | 22:33h | UTC

Combination therapy with rifaximin and lactulose in hepatic encephalopathy: A systematic review and meta-analysis – PLOS One

Commentary: Rifaximin Plus Lactulose Linked to Greater Effectiveness, Decreased Mortality in HE – AJMC

 

Review | The prevention and treatment of nausea and vomiting during tumor therapy.

5 Sep, 2022 | 14:23h | UTC

The Prevention and Treatment of Nausea and Vomiting During Tumor Therapy – Deutsches Ärzteblatt International

Related:

SEOM clinical guideline emesis (2021) – Clinical and Translational Oncology

M-A: Antiemetics for adults for prevention of nausea and vomiting caused by moderately or highly emetogenic chemotherapy.

Prevention of Chemotherapy-Induced Nausea and Vomiting in the Older Patient: Optimizing Outcomes – Drugs & Aging (if the link is paywalled, try this one)

 

Review | Small intestinal bacterial overgrowth breath testing in gastroenterology: clinical utility and pitfalls.

5 Sep, 2022 | 14:21h | UTC

Small Intestinal Bacterial Overgrowth Breath Testing in Gastroenterology: Clinical Utility and Pitfalls – Clinical Gastroenterology and Hepatology

 

Nonalcoholic fatty liver disease: review of management for primary care providers.

5 Sep, 2022 | 14:18h | UTC

Nonalcoholic Fatty Liver Disease: Review of Management for Primary Care Providers – Mayo Clinic Proceedings

 

Systematic Review | Contrast‐enhanced ultrasound for the diagnosis of hepatocellular carcinoma in adults with chronic liver disease.

5 Sep, 2022 | 14:13h | UTC

Contrast‐enhanced ultrasound for the diagnosis of hepatocellular carcinoma in adults with chronic liver disease – Cochrane Library

Summary: How accurate are contrast-enhanced ultrasound scans for detecting hepatocellular carcinoma? – Cochrane Library

 

Meta-analysis of randomized trials | Antibiotic therapy vs. appendicectomy for uncomplicated acute appendicitis.

1 Sep, 2022 | 11:40h | UTC

Randomized clinical trials comparing antibiotic therapy with appendicectomy for uncomplicated acute appendicitis: meta-analysis – BJS Open

Related:

Nonoperative vs Operative Management of Uncomplicated Acute Appendicitis: A Systematic Review and Meta-Analysis – JAMA Surgery

Efficacy and Safety of Non-Operative Management of Uncomplicated Acute Appendicitis Compared to Appendectomy: An Umbrella Review of Systematic Reviews and Meta-Analyses – World Journal of Surgery

Cohort Study: Patient factors associated with appendectomy within 30 days of initiating antibiotic treatment for appendicitis – the presence of an appendicolith was associated with a nearly 2-fold increased risk of undergoing appendectomy within 30 days.

Review: Diagnosis of uncomplicated and complicated appendicitis in adults.

Another RCT evaluating the efficacy and quality of life of antibiotic-only treatment of acute uncomplicated appendicitis.

A Randomized trial comparing antibiotics with appendectomy for appendicitis

Antibiotics alone for uncomplicated appendicitis: Oral Moxifloxacin almost as good as intravenous Ertapenem + oral Levofloxacin

Observational study: 67.1% success rate with nonoperative management of children with uncomplicated appendicitis

Randomized Trial: Quality of Life and Patient Satisfaction at 7-Year Follow-up of Antibiotic Therapy vs. Appendectomy for Uncomplicated Acute Appendicitis

Meta-Analysis: Antibiotic Treatment vs. Appendectomy for Uncomplicated Acute Appendicitis in Adults and Children

Nonoperative treatment for nonperforated appendicitis in children: a systematic review and meta-analysis – Pediatric Surgery International

 

Commentary on Twitter

 

Guideline | Fecal immunochemical testing in patients with signs or symptoms of suspected colorectal cancer.

31 Aug, 2022 | 11:52h | UTC

Faecal immunochemical testing (FIT) in patients with signs or symptoms of suspected colorectal cancer (CRC): a joint guideline from the Association of Coloproctology of Great Britain and Ireland (ACPGBI) and the British Society of Gastroenterology (BSG) – Gut

Commentary: Guidelines update: use of FIT in colorectal cancer referrals – PULSE

 

Practice guidance for the use of Terlipressin for liver cirrhosis–related complications.

31 Aug, 2022 | 11:46h | UTC

Practice guidance for the use of terlipressin for liver cirrhosis–related complications – Therapeutic Advances in Gastroenterology

 

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