Gastroenterology
Randomized trial: Colorectal cancer screening with repeated fecal immunochemical tests detects more colorectal cancer and advanced adenomas compared to screening sigmoidoscopy
25 Nov, 2020 | 09:05h | UTCColorectal cancer screening with repeated fecal immunochemical test versus sigmoidoscopy: baseline results from a randomized trial – Gastroenterology (link to abstract – $ for full-text)
[Abstract Only] In a Phase 2 randomized trial, Semaglutide at high doses improved Nonalcoholic Steatohepatitis (NASH), but with no significant beneficial effects in liver fibrosis
17 Nov, 2020 | 09:31h | UTCA Placebo-Controlled Trial of Subcutaneous Semaglutide in Nonalcoholic Steatohepatitis – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Semaglutide Shows Promise in NASH Phase 2 Study – Medscape (free registration required)
Commentary on Twitter
Patients with nonalcoholic steatohepatitis were randomly assigned to receive subcutaneous semaglutide or placebo. The incidence of NASH resolution was significantly higher with semaglutide than with placebo. #LiverMtg20
— NEJM (@NEJM) November 13, 2020
[Abstract Only] Randomized trial: Intravenous haloperidol more effective than ondansetron for cannabis hyperemesis syndrome
11 Nov, 2020 | 09:08h | UTC
Commentary on Twitter
Excited to have been involved in this practice-changing RCT comparing Haloperidol (superior) to Ondansetron for Cannabis Hyperemesis Syndrome from @Qemerg @therealdraa_ron @savforrester Marco Sivilotti and others! Check it out!https://t.co/ylms5JIO9v
— Andrew Koch Hall (@AKHallMD) November 5, 2020
Guideline synopsis for follow-up colonoscopy after polypectomy. Repeat Col in 7 to 10 y after 1 to 2 tubular adenomas (TA) < 10 mm; Repeat Col in 3 to 5 y after 3 to 4 TA < 10 mm; Repeat Col in 3 y after 5 to 10 TA < 10 mm; Repeat Col in 3 years after 1 or more TA > 10 mm
9 Nov, 2020 | 01:17h | UTCRecommendations for Follow-up Colonoscopy After Polypectomy – JAMA (free for a limited period)
Author interview: New Recommendations for How Often to Repeat Colonoscopy Following Polypectomy
Original guideline: Recommendations for Follow-Up After Colonoscopy and Polypectomy: A Consensus Update by the US Multi-Society Task Force on Colorectal Cancer – Gastroenterology
USPSTF draft statement now recommends starting colorectal cancer screening at 45
28 Oct, 2020 | 08:57h | UTCDraft Recommendation Statement: Colorectal Cancer Screening – U.S. Preventive Services Task Force
Commentaries: Colorectal cancer screening should start five years earlier — at 45 — expert panel says – STAT AND USPSTF Lowers Colorectal Cancer Screening Age to 45 in Draft Recommendation – NEJM Journal Watch
Clinical review: New advances in the diagnosis and management of hepatocellular carcinoma
28 Oct, 2020 | 08:47h | UTCNew advances in the diagnosis and management of hepatocellular carcinoma – The BMJ (free for a limited period)
Commentary on Twitter
Hepatocellular carcinoma is one of the leading causes of cancer related death in the world. Here's a comprehensive and evidence based review of the most recent advances in its surveillance, diagnosis, and treatment #BMJEducationhttps://t.co/zks9enDz76
— The BMJ (@bmj_latest) October 26, 2020
Meta-analysis: Drugs for preventing postoperative nausea and vomiting in adults after general anesthesia
21 Oct, 2020 | 09:13h | UTC
Commentary on Twitter
Very pleased to share our new #NMA on drugs for preventing #postoperative #nausea and #vomiting after general #anaesthesia: https://t.co/vwha2Vd3DL A huge effort (585 studies!), that involved assessing and ranking the effects of 28 drugs and 36 drug combinations from 6 classes.
— Cochrane Anaesthesia & Emergency and Critical Care (@Cochrane_ACE) October 20, 2020
Systematic review: Management of colonic diverticulitis
16 Oct, 2020 | 09:25h | UTCManagement of Colonic Diverticulitis – Agency for Healthcare Research and Quality
Full report: Management of Colonic Diverticulitis
Evidence summary: Management of Colonic Diverticulitis
Non-respiratory presentations of COVID-19, a clinical review
14 Oct, 2020 | 09:33h | UTC
Esophageal emergencies: Another important cause of acute chest pain
12 Oct, 2020 | 00:30h | UTCEsophageal emergencies: another important cause of acute chest pain – Insights into Imaging
[Abstract Only] A Randomized trial comparing antibiotics with appendectomy for appendicitis
6 Oct, 2020 | 00:44h | UTCA Randomized Trial Comparing Antibiotics with Appendectomy for Appendicitis – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Benefits, risks seen with antibiotics-first for appendicitis – University of Washington School of Medicine
Infographic: Deciding Between Antibiotics & Surgery for Appendicitis: Findings from the CODA Study
Commentary on Twitter
For the treatment of appendicitis, antibiotics noninferior to appendectomy on the basis of results of a standard health-status measure. In the antibiotics group, nearly 3 in 10 participants had undergone appendectomy by 90 days. #ACSCC20
— NEJM (@NEJM) October 5, 2020
Virologists who discovered hepatitis C win medicine Nobel
6 Oct, 2020 | 00:12h | UTCVirologists who discovered hepatitis C win medicine Nobel – Nature
See also: Medicine Nobel honors three scientists for discoveries on hepatitis C virus – Science AND Trio wins Nobel Prize in medicine for discovery of hepatitis C virus – STAT
Cohort study: Fecal microbiota transplant is highly effective in real-world practice
4 Oct, 2020 | 23:10h | UTCFecal Microbiota Transplant is Highly Effective in Real-World Practice: Initial Results from the FMT National Registry – Gastroenterology (link to abstract – $ for full-text)
Commentary: 9 in 10 Cured a Month After Fecal Microbiota Transplantation for C. diff – NEJM Journal Watch
Editorial – Stress ulcer prophylaxis: Is mortality a useful endpoint?
30 Sep, 2020 | 09:31h | UTCStress ulcer prophylaxis: Is mortality a useful endpoint? – Intensive Care Medicine
Commentary on Twitter
Stress ulcer prophylaxis: restrict to highest GI bleeding risk #ICU pts; still uncertainties on harmful effects (ie PK interactions?). Early EN, effective if low-risk + reducing underfeeding, to be encouraged. https://t.co/2EOsefikFc
Referring Wang et al https://t.co/MXnfHYyoJ4 pic.twitter.com/Xz8wmTzn62
— Intens Care Med (@yourICM) September 29, 2020
Gastrointestinal complications in critically ill patients with and without COVID-19
25 Sep, 2020 | 02:44h | UTCGastrointestinal Complications in Critically Ill Patients With and Without COVID-19 – JAMA
Commentary on Twitter
#Covid patients have higher incidence of GI complications incl. mesenteric ischemia than propensity score-matched patients without #Covid. Check out our research letter @JAMA_current https://t.co/9RhC4t3JQ5 @ElmohebM @leon_naar @mathiasac @CarolijnKapoen @MahaFarhat @hayfarani
— Lydia Maurer (@LMaurerMD) September 24, 2020
Lower-dose zinc for childhood diarrhea — a randomized, multicenter trial
24 Sep, 2020 | 09:21h | UTC
Commentary on Twitter
In this randomized trial involving children in Tanzania and India, 5 mg and 10 mg of daily zinc were noninferior to 20 mg of zinc for diarrhea and resulted in less vomiting.
— NEJM (@NEJM) September 23, 2020
Things we do for no reason: Routine correction of elevated INR and thrombocytopenia prior to paracentesis in patients with cirrhosis
24 Sep, 2020 | 09:17h | UTCSee collection: Choosing Wisely: Things We Do For No Reason – Journal of Hospital Medicine
Multisystem effects of COVID-19: A concise review for practitioners
16 Sep, 2020 | 09:14h | UTCMultisystem effects of COVID-19: A concise review for practitioners – Postgraduate Medicine
State of the art review: Hepatorenal syndrome
15 Sep, 2020 | 08:41h | UTCHepatorenal syndrome: pathophysiology, diagnosis, and management – The BMJ (free for a limited period)
Commentary on Twitter
Hepatorenal syndrome is a serious complication of cirrhosis that is associated with high morbidity and mortality. This review discusses its definition, pathophysiology, diagnosis, and management of hepatorenal syndromehttps://t.co/m9QnH6n2lJ
— The BMJ (@bmj_latest) September 14, 2020
ACG Guidelines: Diagnosis and management of achalasia
11 Sep, 2020 | 01:18h | UTC
Commentary on Twitter
New ACG Clinical Guideline on the Diagnosis and Management of Achalasia in The American Journal of #Gastroenterology
Full guideline here: https://t.co/7dnQVIA5zk#AmJGastro #EsophagealMotility #MotilityDisorders @BrennanSpiegel @JPandolfinoMD @RenaYadlapati @KatarinaGreer2 pic.twitter.com/zn0eVuxrQr
— ACG (@AmCollegeGastro) September 4, 2020
[Abstract Only] Randomized trial: Aspirin increases major GI bleeding risk by 60% in older individuals
6 Sep, 2020 | 21:30h | UTCSource: EvidenceAlerts
Commentary on Twitter
Aspirin increases GI bleeding risk by 60% in an aspirin RCT
137 total GI bleeds in 90000 person years @Gut_BMJ https://t.co/Hb8h6kZrpo
— Elliot Tapper (@ebtapper) August 8, 2020
[Preprint] Diarrhea and vomiting may be a key sign of Covid-19 in children
4 Sep, 2020 | 02:12h | UTCDiarrhoea and vomiting may be key sign of Covid in children – The Guardian
Original Study: Seroprevalence of SARS-CoV-2 antibodies in children – A prospective multicentre cohort study – medRxiv
Commentary on Twitter
(1/10) Important pre-print study (interpret cautiously) of 992 UK children showing 6.9% had #SARSCoV2 antibodies, suggesting they are at similar risk of infection as adults, & that young and older children are similarly susceptible. 50% were asymptomatic.https://t.co/sUgvIlnmE0 pic.twitter.com/nxeHkAODLF
— Dr Zoë Hyde (@DrZoeHyde) September 3, 2020
AGA Guidelines on the gastrointestinal evaluation of iron deficiency anemia
1 Sep, 2020 | 06:02h | UTC
Prevalence, risk factors, and outcomes of hospitalized patients with COVID-19 presenting as acute pancreatitis
28 Aug, 2020 | 08:41h | UTCCommentary: Covid-19 can present with pancreatitis – MedicalResearch.com
Guideline synopsis: Ulcerative colitis in adults
28 Aug, 2020 | 08:38h | UTCUlcerative Colitis in Adults – JAMA
Podcast: Update on Ulcerative Colitis—2020
Original Guideline: AGA Clinical Practice Guidelines on the Management of Mild-to-Moderate Ulcerative Colitis – Gastroenterology