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Ophthalmology

RCT | Effect of repeated low-level red light on myopia prevention among children in China with premyopia

10 May, 2023 | 15:52h | UTC

Effect of Repeated Low-level Red Light on Myopia Prevention Among Children in China With Premyopia: A Randomized Clinical Trial – JAMA Network Open

Commentary: Repeated Low-Level Red-Light Intervention Prevents Myopia in Children – HealthDay

Related:

Efficacy of atropine for myopia control in children: A meta-analysis of randomized controlled trials – Journal of Family Medicine and Primary Care

Interventions for myopia control in children: a living systematic review and network meta‐analysis – Cochrane Library

RCT | Effect of low-concentration atropine eyedrops vs. placebo on myopia incidence in children

Crossover RCT | Spectacle lenses with highly aspherical lenslets for slowing myopia.

RCT | Effect of text messaging parents of school-aged children on outdoor time to control myopia.

RCT | Myopia control effect of repeated low-level red-light therapy in children.

RCT: Spectacle lenses with aspherical lenslets for myopia control vs. single-vision spectacle lenses.

Randomized trial: Effect of High add power, medium add power, or single-vision contact lenses on myopia progression in children

 

Commentary on Twitter

 


SR | Device‐modified trabeculectomy for glaucoma

17 Apr, 2023 | 12:46h | UTC

Device‐modified trabeculectomy for glaucoma – Cochrane Library

Summary: Device-modified trabeculectomy for glaucoma – Cochrane Library

 


SR | Blood pressure control for diabetic retinopathy

17 Apr, 2023 | 12:45h | UTC

Blood pressure control for diabetic retinopathy – Cochrane Library

Summary: Blood pressure control for diabetic retinopathy – Cochrane Library

 


RCT | Efficacy and safety of a water-free topical cyclosporine, 0.1%, solution for the treatment of dry eye disease

11 Apr, 2023 | 14:10h | UTC

Efficacy and Safety of a Water-Free Topical Cyclosporine, 0.1%, Solution for the Treatment of Moderate to Severe Dry Eye Disease: The ESSENCE-2 Randomized Clinical Trial – JAMA Ophthalmology

Commentary: ESSENCE-2 Trial Confirms Efficacy of Cyclosporine Solution 0.1% for DED – HCP Live

 

Commentary on Twitter

 


M-A | Retinopathy of prematurity and neurodevelopmental outcomes in preterm infants

10 Apr, 2023 | 13:36h | UTC

Retinopathy of prematurity and neurodevelopmental outcomes in preterm infants: A systematic review and meta-analysis – Frontiers in Pediatrics

 


SR | Anti‐vascular endothelial growth factor for neovascular glaucoma

10 Apr, 2023 | 13:33h | UTC

Anti‐vascular endothelial growth factor for neovascular glaucoma – Cochrane Database of Systematic Reviews

 


M-A | Efficacy of atropine for myopia control in children

5 Apr, 2023 | 12:45h | UTC

Efficacy of atropine for myopia control in children: A meta-analysis of randomized controlled trials – Journal of Family Medicine and Primary Care

Related:

Interventions for myopia control in children: a living systematic review and network meta‐analysis – Cochrane Library

RCT | Effect of low-concentration atropine eyedrops vs. placebo on myopia incidence in children

Crossover RCT | Spectacle lenses with highly aspherical lenslets for slowing myopia.

RCT | Effect of text messaging parents of school-aged children on outdoor time to control myopia.

RCT | Myopia control effect of repeated low-level red-light therapy in children.

RCT: Spectacle lenses with aspherical lenslets for myopia control vs. single-vision spectacle lenses.

Randomized trial: Effect of High add power, medium add power, or single-vision contact lenses on myopia progression in children

 


RCT | Pulsed oral azithromycin vs. 6-week oral doxycycline for moderate to severe meibomian gland dysfunction

31 Mar, 2023 | 13:33h | UTC

Pulsed Oral Azithromycin vs 6-Week Oral Doxycycline for Moderate to Severe Meibomian Gland Dysfunction: A Randomized Clinical Trial – JAMA Ophthalmology (link to abstract – $ for full-text)

Commentary: 3-Week MGD treatment equivalent to 6-week course in efficacy and adverse events – Ophthalmology Times

 

Commentary on Twitter

 


SR | Anti‐vascular endothelial growth factor for proliferative diabetic retinopathy

29 Mar, 2023 | 13:15h | UTC

Anti‐vascular endothelial growth factor for proliferative diabetic retinopathy – Cochrane Library

Summary: Injections of anti-vascular endothelial growth factor for advanced diabetic retinopathy – Cochrane Library

 


Cohort Study | Retinal artery occlusion linked to a 7-fold higher mortality rate from CV and cerebrovascular diseases

23 Mar, 2023 | 13:04h | UTC

Summary: This nationwide cohort study analyzed the incidence of retinal artery occlusion (RAO) in Korea from 2002 to 2018, along with related mortality and causes of death. The incidence of RAO was found to be 7.38 per 100,000 person-years, with a higher incidence of noncentral RAO compared to central RAO.

Patients with RAO had a mortality rate about 7 times higher than the general population, primarily due to cardiovascular or cerebrovascular diseases. The findings emphasize the need to address the risk of cardiovascular or cerebrovascular disease in patients newly diagnosed with RAO.

Article: Incidence of Retinal Artery Occlusion and Related Mortality in Korea, 2005 to 2018 – JAMA Network Open

Invited Commentary: Long-term Management Considerations for Retinal Artery Occlusion and Cardiovascular and Cerebrovascular Mortality – JAMA Network Open

 


SR | Topical antibiotics modestly improve resolution of acute bacterial conjunctivitis

21 Mar, 2023 | 13:33h | UTC

Summary: The Cochrane Review evaluated the benefits and potential side effects of antibiotic therapy in treating acute bacterial conjunctivitis. The authors included 21 randomized controlled trials, with a total of 8,805 participants. The trials evaluated the effectiveness of topical antibiotic treatments in the form of drops or ointments, and were heterogeneous in terms of eligibility criteria, antibiotic drug class, duration of treatment, and outcomes assessed.

The review found that antibiotics likely improved clinical cure by 26% compared with placebo, with no evidence of serious systemic side effects reported in either the antibiotic or placebo group. Fluoroquinolones were found to have fewer ocular side effects compared to non-fluoroquinolones.

Overall, the review suggests that the use of topical antibiotics may be considered to achieve better clinical and microbiologic efficacy than placebo in treating acute bacterial conjunctivitis.

Article: Antibiotics versus placebo for acute bacterial conjunctivitis – Cochrane Library

Summary: What are the benefits and harms of antibiotics for acute bacterial conjunctivitis? – Cochrane Library

 


M-A | Global prevalence of diabetic retinopathy in pediatric type 2 diabetes

20 Mar, 2023 | 13:12h | UTC

Global Prevalence of Diabetic Retinopathy in Pediatric Type 2 Diabetes: A Systematic Review and Meta-analysis – JAMA Network Open

 


SR | Interventions for acute non‐arteritic central retinal artery occlusion

3 Mar, 2023 | 13:36h | UTC

Interventions for acute non‐arteritic central retinal artery occlusion – Cochrane Library

Summary: Treatments for acute central retinal artery occlusion (blockage of the blood supply to the retina of the eye) – Cochrane Library

 

Commentary on Twitter

 


SR | Trifocal intraocular lenses vs. bifocal intraocular lenses after cataract extraction among participants with presbyopia

2 Mar, 2023 | 12:46h | UTC

Trifocal intraocular lenses versus bifocal intraocular lenses after cataract extraction among participants with presbyopia – Cochrane Library

Summary: Trifocal versus bifocal lenses implantation after cataract surgery – Cochrane Library

 


Review | Contact lens–associated keratitis — An often underestimated risk

24 Feb, 2023 | 13:33h | UTC

Contact Lens–Associated Keratitis— an Often Underestimated Risk – Deutsches Ärzteblatt international

 


M-A | Interventions for myopia control in children

22 Feb, 2023 | 12:36h | UTC

Interventions for myopia control in children: a living systematic review and network meta‐analysis – Cochrane Library

Related:

RCT | Effect of low-concentration atropine eyedrops vs. placebo on myopia incidence in children

Crossover RCT | Spectacle lenses with highly aspherical lenslets for slowing myopia.

RCT | Effect of text messaging parents of school-aged children on outdoor time to control myopia.

RCT | Myopia control effect of repeated low-level red-light therapy in children.

RCT: Spectacle lenses with aspherical lenslets for myopia control vs. single-vision spectacle lenses.

Randomized trial: Effect of High add power, medium add power, or single-vision contact lenses on myopia progression in children

 


Phase 2b RCT | Effects of OPT-302, a VEGF-C/D inhibitor for neovascular age-related macular degeneration

22 Feb, 2023 | 12:21h | UTC

A randomized controlled trial of OPT-302, a VEGF-C/D inhibitor for neovascular age-related macular degeneration – Ophthalmology

 


RCT | Effect of low-concentration atropine eyedrops vs. placebo on myopia incidence in children

15 Feb, 2023 | 16:09h | UTC

Summary: The study aimed to evaluate the efficacy of low-concentration atropine eyedrops at 0.05% and 0.01% concentration for delaying the onset of myopia in children. The randomized, placebo-controlled, double-masked trial enrolled 474 nonmyopic children aged 4 through 9 years. Participants were assigned to 0.05% atropine, 0.01% atropine, and placebo groups and had eyedrops applied once nightly in both eyes over 2 years. The results showed that the 0.05% atropine eyedrops resulted in a significantly lower incidence of myopia and a lower percentage of participants with fast myopic shift at 2 years compared with placebo. However, there was no significant difference between 0.01% atropine and placebo. More research is necessary to replicate the results, determine whether this approach delays or prevents myopia, and evaluate its long-term safety.*

Article: Effect of Low-Concentration Atropine Eyedrops vs Placebo on Myopia Incidence in Children: The LAMP2 Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Delaying the Onset of Nearsightedness – JAMA (free for a limited period)

Commentaries:

Atropine Eyedrops Associated With Lower Incidence of Myopia, Myopic Shift – AJMC

Low-Concentration Atropine Eyedrops Linked to Lower Myopia Incidence in Children – HCP Live

0.05 Percent Atropine Eye Drops Result in Lower Incidence of Myopia – HealthDay

 

Commentary on Twitter

 

*Note: This summary was created through the collaboration of a medical editor and ChatGPT.

 


M-A | Prevalence of ocular candidiasis and Candida endophthalmitis in patients with candidemia

14 Feb, 2023 | 10:43h | UTC

Prevalence of ocular candidiasis and Candida endophthalmitis in patients with candidemia: A systematic review and meta-analysis – Clinical Infectious Diseases

 

Commentary on Twitter

 


Review | Anisocoria in the ED: pathophysiology, evaluation, and management

14 Feb, 2023 | 10:41h | UTC

Anisocoria in the ED: Pathophysiology, Evaluation, and Management – emDocs

 


52-week results from two phase III trials of brolucizumab for diabetic macular edema

8 Feb, 2023 | 12:25h | UTC

KESTREL and KITE: 52-Week Results From Two Phase III Pivotal Trials of Brolucizumab for Diabetic Macular Edema – American Journal of Ophthalmology

 


Childhood blindness incidence and etiologies trends in Israel 2014–2020: what should we focus on?

1 Feb, 2023 | 12:59h | UTC

Childhood blindness incidence and aetiologies trends in Israel 2014–2020: what should we focus on? – Eye

 


Cohort Study | Association of retinal age gap and risk of kidney failure

31 Jan, 2023 | 13:38h | UTC

Association of Retinal Age Gap and Risk of Kidney Failure: A UK Biobank Study – American Journal of Kidney Diseases

News Release: Aging in the eye predicts risk for kidney failure – National Kidney Foundation

Related:

Association of Retinal Age Gap With Arterial Stiffness and Incident Cardiovascular Disease – Stroke

Cohort Study | Artificial intelligence-enabled retinal vasculometry for prediction of cardiovascular diseases.

Retinal photograph-based deep learning predicts biological age, and stratifies morbidity and mortality risk.

An artificial intelligence system can help predict myocardial infarction through retinal scans and minimal personal information.

Study shows that the retinal age gap might be a potential biomarker of aging linked to increased mortality risk.

 

Commentary on Twitter

 


Cross-Sectional Study | Association of maternal and paternal astigmatism with child astigmatism

31 Jan, 2023 | 13:35h | UTC

Association of Maternal and Paternal Astigmatism With Child Astigmatism in the Hong Kong Children Eye Study – JAMA Network Open

 


Cohort Study | Association between rate of ganglion cell complex thinning and rate of central visual field loss

31 Jan, 2023 | 13:33h | UTC

Association Between Rate of Ganglion Cell Complex Thinning and Rate of Central Visual Field Loss – JAMA Ophthalmology (link to abstract – $ for full-text)

Commentaries:

Rapid Initial GCC Thinning Associated with Faster Rates of Central Visual Field Loss – HCP Live

Ganglion Cell Complex Thinning Associated With Faster Central Visual Field Decline – AJMC

 


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