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Evidence Based Medicine

Perspective | SARS-CoV-2 human challenge studies — establishing the model during an evolving pandemic.

23 Jul, 2021 | 10:49h | UTC

SARS-CoV-2 Human Challenge Studies — Establishing the Model during an Evolving Pandemic – New England Journal of Medicine

Related: World’s first coronavirus “Human Challenge” study receives ethics approval in the UK (several texts on the subject) AND Are SARS-CoV-2 Human Challenge Trials Ethical? – “A clinical trial is underway in the UK in which young, healthy participants are exposed deliberately to SARS-CoV-2 to assess the viral inoculum needed to produce an infection and to test vaccine efficacy”.

 


Opinion | Expanding evidence for clinical care of older adults: beyond clinical trial traditions and finding new approaches.

23 Jul, 2021 | 10:31h | UTC

Expanding Evidence for Clinical Care of Older Adults: Beyond Clinical Trial Traditions and Finding New Approaches – JAMA (free for a limited period)

 


Survey finds 8% of researchers have falsified or fabricated data.

23 Jul, 2021 | 10:28h | UTC

8% of researchers in Dutch survey have falsified or fabricated data – Nature

Original study and commentaries: Landmark research integrity survey finds questionable practices are surprisingly common.

Related: Opinion | Time to assume that health research is fraudulent until proven otherwise? AND How a Data Detective Exposed Suspicious Medical Trials

 


Opinion | Kids aren’t just littler adults – here’s why they need their own clinical trials for a COVID-19 vaccine.

22 Jul, 2021 | 10:55h | UTC

Kids aren’t just littler adults – here’s why they need their own clinical trials for a COVID-19 vaccine – The Conversation

 


Is the cure really worse than the disease? The health impacts of lockdowns during COVID-19 – “While there are certainly costs to be expected from intervening against COVID-19—every decision has a cost, after all—the counterfactual of an unmitigated epidemic makes these restrictions far less damaging than some have suggested”.

21 Jul, 2021 | 10:46h | UTC

Is the cure really worse than the disease? The health impacts of lockdowns during COVID-19 – BMJ Global Health

Commentaries: Expert reaction to a narrative review looking at the health impacts of lockdowns – Science Media Centre AND Lockdowns do not harm health more than Covid, say researchers – The Guardian

 

Commentary on Twitter (thread – click for more)

 


Fauci says natural origins theory of coronavirus is still the most likely.

18 Jul, 2021 | 23:40h | UTC

Fauci says natural origins theory of coronavirus is still the most likely – CNN

Related article (preprint): The Origins of SARS-CoV-2: A Critical Review – Zenodo

See also: A Group of Scientists Presses a Case Against the Lab Leak Theory of Covid – The New York Times (a few articles per month are free) AND Leading scientists push back against Wuhan lab leak theory – The Age

Related: Opinion | The Covid-19 lab leak theory is a tale of weaponized uncertainty.

 


Why was a major study on ivermectin for covid-19 just retracted?

16 Jul, 2021 | 11:11h | UTC

Why Was a Major Study on Ivermectin for COVID-19 Just Retracted? – Grifter Analysis and Review

See also: Huge study supporting ivermectin as Covid treatment withdrawn over ethical concerns – The Guardian AND Some problems in the dataset of a large study of Ivermectin for the treatment of Covid-19 – Nick Brown’s Blog AND Is Ivermectin for Covid-19 Based on Fraudulent Research? – Gideon M-K; Health Nerd

 

Commentary on Twitter (thread – click for more)

 


Opinion | The case for mandating COVID-19 vaccines for health care workers.

14 Jul, 2021 | 11:22h | UTC

The Case for Mandating COVID-19 Vaccines for Health Care Workers – Annals of Internal Medicine

News release: Case is strong for mandating COVID-19 vaccination for health care workers – American College of Physicians

 

Commentary on Twitter

 


Landmark research integrity survey finds questionable practices are surprisingly common.

12 Jul, 2021 | 01:32h | UTC

Landmark research integrity survey finds questionable practices are surprisingly common – Science (a few articles per month are free)

Original studies (preprint): Prevalence of questionable research practices, research misconduct and their potential explanatory factors: a survey among academic researchers in The Netherlands – MetaArXiv AND Prevalence of responsible research practices and their potential explanatory factors: a survey among academic researchers in The Netherlands – MetaArXiv

Related: Opinion | Time to assume that health research is fraudulent until proven otherwise?

 


Review: most common joint procedures not backed by high quality evidence – “Urgent need exists to prioritize research into common orthopedic interventions”.

12 Jul, 2021 | 01:26h | UTC

News release: Most common joint procedures not backed by high quality evidence – The BMJ

Original study: Common elective orthopaedic procedures and their clinical effectiveness: umbrella review of level 1 evidence – The BMJ

 

Commentary on Twitter

 


Editorial: Aducanumab for Alzheimer’s disease?

12 Jul, 2021 | 01:15h | UTC

Aducanumab for Alzheimer’s disease? – The BMJ

Related: FDA approvement of Alzheimer’s drug sparks controversy among doctors.

 

Commentary on Twitter

 


Recommendations for including or reviewing patient reported outcome endpoints in grant applications.

12 Jul, 2021 | 01:12h | UTC

Recommendations for including or reviewing patient reported outcome endpoints in grant applications – The BMJ

 


Perspective | “‘Too good to be true’: Doubts swirl around trial that saw 77% reduction in COVID-19 mortality”.

9 Jul, 2021 | 10:13h | UTC

‘Too good to be true’: Doubts swirl around trial that saw 77% reduction in COVID-19 mortality – Science (a few articles per month are free)

 


Opinion | Time to assume that health research is fraudulent until proven otherwise?

8 Jul, 2021 | 08:58h | UTC

Time to assume that health research is fraudulent until proven otherwise? – The BMJ Opinion

Related: How a Data Detective Exposed Suspicious Medical Trials

 

Commentary on Twitter

 


A critical review on altmetrics: can we measure the social impact factor?

7 Jul, 2021 | 08:42h | UTC

A critical review on altmetrics: can we measure the social impact factor? – Insights into Imaging

Related: Altmetric Score Has a Stronger Relationship With Article Citations Than Journal Impact Factor and Open Access Status: A Cross-Sectional Analysis of 4,022 Sports Science Articles – Journal of Orthopaedic & Sports Physical Therapy (link to abstract – $ for full-text)

 

Commentary on Twitter

 


Editorial | Do not just sit there, do something … but do no harm: the worrying aspects of COVID-19 experimental interventions.

6 Jul, 2021 | 10:14h | UTC

Do not just sit there, do something … but do no harm: the worrying aspects of COVID-19 experimental interventions – Intensive Care Medicine

 

Commentary on Twitter

 


Perspective | Science, not speculation, is essential to determine how SARS-CoV-2 reached humans.

6 Jul, 2021 | 10:12h | UTC

Science, not speculation, is essential to determine how SARS-CoV-2 reached humans – The Lancet

 


When is ‘self-plagiarism’ OK? New guidelines offer researchers rules for recycling text.

6 Jul, 2021 | 10:02h | UTC

When is ‘self-plagiarism’ OK? New guidelines offer researchers rules for recycling text – Science (a few articles per month are free)

 


Review | Users’ guide to medical decision analysis.

5 Jul, 2021 | 01:43h | UTC

Users’ Guide to Medical Decision Analysis – Mayo Clinic Proceedings

 


Study Commentary | “Blood test finds 50 types of cancer” – we’ve been down this path before.

5 Jul, 2021 | 01:31h | UTC

“Blood test finds 50 types of cancer” – we’ve been down this path before – HealthNewsReview

Original study: Clinical validation of a targeted methylation-based multi-cancer early detection test using an independent validation set – Annals of Oncology

 


The COVID pandemic’s lingering impact on clinical trials – “Medical researchers are beginning to shift their focus away from COVID-19 — but the pandemic could continue to affect studies focused on other diseases.”

29 Jun, 2021 | 09:57h | UTC

The COVID pandemic’s lingering impact on clinical trials – Nature

 


EBM Analysis | Does tranexamic acid work for everything? For anything?

29 Jun, 2021 | 09:53h | UTC

Does TXA work for everything? For anything? – First10EM

 


Impact factor abandoned by Dutch university in hiring and promotion decisions – “Faculty and staff members at Utrecht University will be evaluated by their commitment to open science”.

28 Jun, 2021 | 09:37h | UTC

Impact factor abandoned by Dutch university in hiring and promotion decisions – Nature

Related: Open-access Science Funders Announce Price Transparency Rules for Publishers (several resources on the subject) AND A new mandate highlights costs, benefits of making all scientific articles free to read – Science AND A guide to Plan S: the open-access initiative shaking up science publishing – Nature

 


Opinion | A strategy to reduce the carbon footprint of clinical trials.

24 Jun, 2021 | 09:45h | UTC

A strategy to reduce the carbon footprint of clinical trials – The Lancet

 


Interactive Infographic | Interpreting a lateral flow SARS-CoV-2 antigen test – “This calculator demonstrates how interpreting a covid-19 lateral flow device (LFD) result varies according to the pre-test probability, and the sensitivity and specificity of the LFD used”.

23 Jun, 2021 | 10:29h | UTC

Interpreting a lateral flow SARS-CoV-2 antigen test – The BMJ

 


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