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Evidence-based Medicine

Opinion | Is it time for Evidence-Based Medicine 2.0?

21 Oct, 2021 | 09:59h | UTC

Is it time for Evidence-Based Medicine 2.0? – Centre for Evidence-Based Medicine

 


Opinion | Understanding of research results, evidence summaries and their applicability—not critical appraisal—are core skills of medical curriculum.

21 Oct, 2021 | 09:57h | UTC

Understanding of research results, evidence summaries and their applicability—not critical appraisal—are core skills of medical curriculum – BMJ Evidence-Based Medicine

 

Commentary on Twitter

 


Users’ guides to the medical literature: how to interpret and use a clinical practice guideline or recommendation.

20 Oct, 2021 | 10:09h | UTC

How to Interpret and Use a Clinical Practice Guideline or Recommendation: Users’ Guides to the Medical Literature – JAMA (free for a limited period)

Author Interview: How to Interpret and Use a Clinical Practice Guideline

 


Long-term consequences of the misuse of ivermectin data.

19 Oct, 2021 | 09:56h | UTC

Long-term consequences of the misuse of ivermectin data – The Lancet Infectious Diseases

Related:

Ivermectin: How false science created a Covid ‘miracle’ drug.

Fraudulent ivermectin studies open up new battleground between science and misinformation.

The lesson of ivermectin: meta-analyses based on summary data alone are inherently unreliable.

Ivermectin: Cochrane’s most talked about review so far, ever. Why?

Flawed ivermectin preprint highlights challenges of COVID drug studies.

Systematic review: no evidence to support the use of Ivermectin for treating or preventing COVID-19.

Why was a major study on ivermectin for covid-19 just retracted?

RCT: Ivermectin does not prevent hospitalizations in patients with COVID-19.

Ivermectin for the treatment of COVID-19: A systematic review and meta-analysis of randomized controlled trials – “IVM did not reduce all-cause mortality, length of stay or viral clearance in RCTs in COVID-19 patients with mostly mild disease”.

Ivermectin is the new hydroxychloroquine, take 2 – “Ivermectin shouldn’t be used to treat COVID-19 outside of the context of a well-designed clinical trial”.

Therapeutics and COVID-19 | WHO guideline update advises Ivermectin should only be used to treat COVID-19 within clinical trials

RCT: Ivermectin does not improve time to resolution of symptoms among adults with mild COVID-19

 

Commentary on Twitter

 


Opinion | Multi-cancer screening tests: communicating about risks should be prioritized.

19 Oct, 2021 | 08:49h | UTC

Multi-cancer screening tests: communicating about risks should be prioritized. – The American Journal of Medicine

 


Viewpoint: Surgical overtreatment and shared decision-making—the limits of choice. – “Payment models further incentivize surgical intervention. Fee-for-service payment plans reward surgeons for operating, not for ensuring that surgery is right for a patient”.

17 Oct, 2021 | 21:17h | UTC

Surgical Overtreatment and Shared Decision-making—The Limits of Choice – JAMA Surgery (free for a limited period)

 

Commentary on Twitter

 


Editorial: Covid-19 treatments and vaccines must be evaluated in pregnancy.

15 Oct, 2021 | 02:41h | UTC

Covid-19 treatments and vaccines must be evaluated in pregnancy – The BMJ

Related:

Two observational studies suggest spontaneous abortion is not increased following COVID-19 mRNA vaccination during pregnancy.

Study shows high effectiveness of the Pfizer mRNA COVID-19 vaccine in pregnancy.

5 Crucial Things to Know About COVID-19 Vaccines and Pregnancy.

CDC Guidance: Pregnant people should be vaccinated against COVID-19.

ACOG and SMFM Recommend COVID-19 Vaccination for Pregnant Individuals – “ACOG encourages its members to enthusiastically recommend vaccination to their patients.”

Cohort study: Pfizer/BioNTech COVID vaccine associated with 78% lower risk of Covid-19 in pregnancy.

 

Commentary on Twitter

 


Systematic Review: “Formula milk trials have a high risk of bias, almost always report favorable conclusions, lack transparency, and selectively report findings”.

15 Oct, 2021 | 02:25h | UTC

News release: Formula milk trials are not reliable, warn researchers – Imperial College London

Original study: Conduct and reporting of formula milk trials: systematic review – The BMJ

 


How to be a good science communicator.

14 Oct, 2021 | 10:13h | UTC

How to be a good science communicator – Nature Medicine

 

Commentary on Twitter

 


Podcast with Dr Walter Willett: CardioNutrition – Why are findings from prospective, epidemiologic cohort studies important in informing dietary recommendations?

14 Oct, 2021 | 09:49h | UTC

ACC CardiaCast: CardioNutrition – Why Are Findings From Prospective, Epidemiologic Cohort Studies Important In Informing Dietary Recommendations? – American College of Cardiology

 

Commentary on Twitter

 


Editorial: How to develop a quality research article and avoid a journal desk rejection.

13 Oct, 2021 | 01:18h | UTC

Editorial: How to develop a quality research article and avoid a journal desk rejection – International Journal of Information Management (free for a limited period)

 


Bioethics | The Trolley Problem and Vaccinating Young People Against COVID-19.

10 Oct, 2021 | 21:50h | UTC

The Trolley Problem and Vaccinating Young People Against COVID-19 – Science-Based Medicine

 


Ivermectin: How false science created a Covid ‘miracle’ drug.

8 Oct, 2021 | 10:24h | UTC

Ivermectin: How false science created a Covid ‘miracle’ drug – BBC

 

Commentary on Twitter

 


GRADE guidelines 32: GRADE offers guidance on choosing targets of GRADE certainty of evidence ratings.

7 Oct, 2021 | 10:11h | UTC

GRADE guidelines 32: GRADE offers guidance on choosing targets of GRADE certainty of evidence ratings – Journal of Clinical Epidemiology

 


Key concepts in clinical epidemiology: Stepped wedge trials.

7 Oct, 2021 | 10:10h | UTC

Key concepts in clinical epidemiology: Stepped wedge trials – Journal of Clinical Epidemiology

 


Evaluating agreement between bodies of evidence from randomized controlled trials and cohort studies in nutrition research: meta-epidemiological study.

5 Oct, 2021 | 08:48h | UTC

Evaluating agreement between bodies of evidence from randomised controlled trials and cohort studies in nutrition research: meta-epidemiological study – The BMJ

 

Commentary on Twitter

 


Guide to Statistics and Methods: Interim Analyses During Group Sequential Clinical Trials.

3 Oct, 2021 | 22:30h | UTC

Interim Analyses During Group Sequential Clinical Trials – JAMA (free for a limited period)

 


Publishers unite to tackle doctored images in research papers.

30 Sep, 2021 | 10:12h | UTC

Publishers unite to tackle doctored images in research papers – Nature

 


M-A: Magnitude of the placebo response across treatment modalities used for treatment-resistant depression in adults.

29 Sep, 2021 | 10:04h | UTC

Magnitude of the Placebo Response Across Treatment Modalities Used for Treatment-Resistant Depression in Adults: A Systematic Review and Meta-analysis – JAMA Network Open

Invited Commentary: Treatment-Resistant Depression—Resistant to Placebos as Well? – JAMA Network Open

 

Commentaries on Twitter

(thread – click for more)

 


Editorial: It is time for consensus on ‘consensus statements’?

29 Sep, 2021 | 10:01h | UTC

It is time for consensus on ‘consensus statements’? – British Journal of Sports Medicine

 

Commentary on Twitter

 


Opinion | ‘Health equity tourists’: How white scholars are colonizing research on health disparities.

29 Sep, 2021 | 09:53h | UTC

‘Health equity tourists’: How white scholars are colonizing research on health disparities – STAT

 


Opinion: Paying participants isn’t the way to improve clinical trial recruitment.

29 Sep, 2021 | 09:54h | UTC

Paying participants isn’t the way to improve clinical trial recruitment – STAT

 


Bayesian interpretation of p values in clinical trials.

28 Sep, 2021 | 09:01h | UTC

Bayesian interpretation of p values in clinical trials – BMJ Evidence-Based Medicine

 

Commentary on Twitter

 


New guidelines to improve reporting standards of studies that investigate causal mechanisms.

28 Sep, 2021 | 09:00h | UTC

News release: New guidelines to improve reporting standards of studies that investigate causal mechanisms – University of Oxford

Original article: A Guideline for Reporting Mediation Analyses of Randomized Trials and Observational Studies: The AGReMA Statement – JAMA (free for a limited period)

Commentary: Reporting Findings From Mediation Analyses – JAMA (free for a limited period)

 

Commentary on Twitter (thread – click for more)

 


Beware survivorship bias in advice on science careers – “For objective careers advice, talk to those who left science as well as those who stayed”.

28 Sep, 2021 | 08:59h | UTC

Beware survivorship bias in advice on science careers – Nature

 


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