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Evidence Based Medicine

Large clinical trial to study repurposed drugs to treat COVID-19 symptoms

21 Apr, 2021 | 06:59h | UTC

Large clinical trial to study repurposed drugs to treat COVID-19 symptoms – NIH News Releases

 


Clinical trial completion rates decline during COVID-19 pandemic

20 Apr, 2021 | 05:59h | UTC

Clinical trial completion rates decline during COVID-19 pandemic – Penn State

Original study: Assessing the Impact of COVID‐19 on Registered Interventional Clinical Trials – Clinical and Translational Science

 


Perspective | Ivermectin is the new Hydroxychorloquine

16 Apr, 2021 | 06:28h | UTC

Ivermectin is the new Hydroxychorloquine – Science-Based Medicine

 


Study shows practitioners overestimate the probability of disease before and after testing

14 Apr, 2021 | 01:44h | UTC

Accuracy of Practitioner Estimates of Probability of Diagnosis Before and After Testing – JAMA Internal Medicine (free for a limited period)

Commentary: Physicians, Probabilities, and Populations—Estimating the Likelihood of Disease for Common Clinical Scenarios – JAMA Internal Medicine (free for a limited period)

 

Commentary on Twitter

 


Viewpoint | Industry-Sponsored Speaker Programs—End of the Line?

14 Apr, 2021 | 01:36h | UTC

Industry-Sponsored Speaker Programs—End of the Line? – JAMA

 


A guide to Plan S: the open-access initiative shaking up science publishing

9 Apr, 2021 | 03:11h | UTC

A guide to Plan S: the open-access initiative shaking up science publishing – Nature

Related: Open-access Science Funders Announce Price Transparency Rules for Publishers (several resources on the subject) AND A new mandate highlights costs, benefits of making all scientific articles free to read – Science

 


Perspective | Evidence isn’t Everything – Evidence-based medicine and statin decision-making

8 Apr, 2021 | 08:41h | UTC

Evidence isn’t Everything – Evidence-based medicine and statin decision-making

 

Commentary on Twitter

 


Exceedingly rare side effects reported with AstraZeneca vaccine in the UK – 22 cases of cerebral venous sinus thrombosis with low levels of platelets out of 18 million vaccinated individuals

5 Apr, 2021 | 01:45h | UTC

Covid-19: Seven UK blood clot deaths after AstraZeneca vaccine – BBC

Original report: Coronavirus vaccine – weekly summary of Yellow Card reporting – Medicines and Healthcare products Regulatory Agency

Related opinion: Undermining the AstraZeneca jab is a dangerous act of political folly – The Guardian

“Based on current experience, the expected benefits of both COVID-19 vaccines in preventing COVID-19 and its serious complications far outweigh any known side effects”

 


Opinion | How to lose friends and alienate people? On the problems of vaccine passports

5 Apr, 2021 | 01:42h | UTC

How to lose friends and alienate people? On the problems of vaccine passports – The BMJ Opinion

Related: Resistance from health experts and business owners could doom ‘vaccine passports’ even before they launch – STAT AND How Vaccine Passports Will Worsen Inequities In Global Health – Microbiology AND Vaccine certificates: does the end justify the means? – The Lancet Microbe AND Covid-19 vaccine passports will harm sustainable development – The BMJ Opinion AND Covid-19 vaccine passports and vaccine hesitancy: freedom or control? – The BMJ Opinion AND “Vaccine Passport” Certification — Policy and Ethical Considerations – New England Journal of Medicine AND Interim position paper: considerations regarding proof of COVID-19 vaccination for international travellers – World Health Organization

 

Commentary on Twitter

 


Video: Why you can’t compare Covid-19 vaccines

2 Apr, 2021 | 09:33h | UTC

Why you can’t compare Covid-19 vaccines – Vox

 


Opinion | COVID-19: underpowered randomized trials, or no randomized trials?

1 Apr, 2021 | 03:42h | UTC

COVID-19: underpowered randomised trials, or no randomised trials? – Trials

 

Commentary on Twitter

 


Research Methods & Reporting | The PRISMA 2020 statement: an updated guideline for reporting systematic reviews

30 Mar, 2021 | 03:03h | UTC

The PRISMA 2020 statement: an updated guideline for reporting systematic reviews – The BMJ

See also: PRISMA 2020 explanation and elaboration: updated guidance and exemplars for reporting systematic reviews – The BMJ

 


Analysis of conflicts of interest among authors and researchers of European clinical guidelines in cardiovascular medicine

30 Mar, 2021 | 02:53h | UTC

Analysis of conflicts of interest among authors and researchers of European clinical guidelines in cardiovascular medicine – Clinical Medicine Journal

 

Commentary on Twitter (thread – click for more)

 


Cochrane Library Editorial: Contested effects and chaotic policies: the 2020 story of (hydroxy) chloroquine for treating COVID‐19

28 Mar, 2021 | 22:55h | UTC

Contested effects and chaotic policies: the 2020 story of (hydroxy) chloroquine for treating COVID‐19 – Cochrane Library

Commentary and Infographic: Is chloroquine or hydroxychloroquine useful in treating people with COVID-19, or in preventing infection in people who have been exposed to the virus? – Cochrane Library

Original review: Chloroquine or hydroxychloroquine for prevention and treatment of COVID‐19 – Cochrane Library

 

Commentary on Twitter

 


Opinion | Understanding of research results, evidence summaries and their applicability—not critical appraisal—are core skills of medical curriculum

28 Mar, 2021 | 22:16h | UTC

Understanding of research results, evidence summaries and their applicability—not critical appraisal—are core skills of medical curriculum – BMJ Evidence-Based Medicine

 

Commentaries on Twitter

 


Evolution of the randomized clinical trial in the era of precision oncology

26 Mar, 2021 | 08:35h | UTC

Evolution of the Randomized Clinical Trial in the Era of Precision Oncology – JAMA Oncology

 

Commentary on Twitter


FDA approval standards for anticancer agents — lessons from two recent approvals in breast cancer

26 Mar, 2021 | 08:30h | UTC

FDA approval standards for anticancer agents — lessons from two recent approvals in breast cancer – Nature Reviews Clinical Oncology

 

Commentary on Twitter

 


Pushing back against U.S. health officials, AstraZeneca says new analysis confirms efficacy of its Covid-19 vaccine

26 Mar, 2021 | 09:01h | UTC

Pushing back against U.S. health officials, AstraZeneca says new analysis confirms efficacy of its Covid-19 vaccine – STAT

News release: AZD1222 US Phase III primary analysis confirms safety and efficacy –  AstraZeneca

See also: Latest results put Oxford–AstraZeneca COVID vaccine back on track – Nature AND AstraZeneca’s absurd and unprecedented dispute with regulators, explained – Vox AND Expert reaction to press release from AstraZeneca announcing primary data on safety and efficacy from the US trial of the Oxford-AstraZeneca COVID-19 vaccine – Science Media Centre AND AstraZeneca says COVID-19 vaccine 76% effective in new analysis, to seek U.S. approval – Reuters AND AstraZeneca’s new data showing Covid vaccine slightly less effective than suggested doesn’t worry experts – The Guardian AND Latest AstraZeneca Report Supports Effectiveness Of COVID Vaccine – NPR

 


Covid: The London bus trip that saved maybe a million lives (about the creation of the RECOVERY Trial)

26 Mar, 2021 | 08:53h | UTC

Covid: The London bus trip that saved maybe a million lives – BBC

Related: Covid-19: The Inside Story of the RECOVERY Trial

 

Commentary on Twitter

 


Perspective | Leveraging Open Science to Accelerate Research

25 Mar, 2021 | 08:37h | UTC

Leveraging Open Science to Accelerate Research – New England Journal of Medicine

 


Opinion | We need to start thinking more critically — and speaking more cautiously — about long Covid

23 Mar, 2021 | 02:28h | UTC

We need to start thinking more critically — and speaking more cautiously — about long Covid – STAT

 


Editorial | Scholarly communications harmed by covid-19

23 Mar, 2021 | 02:25h | UTC

Scholarly communications harmed by covid-19 – The BMJ

 

Commentaries on Twitter

 


Opinion | An open plea for dignity and respect in science

23 Mar, 2021 | 02:24h | UTC

An open plea for dignity and respect in science – The BMJ Opinion

Related: Scientists who express different views on Covid-19 should be heard, not demonized – STAT

 

Commentary on Twitter

 


Bioethics | “Europe’s Vaccine Ethics Call: Do No Harm and Let More Die?”

21 Mar, 2021 | 21:50h | UTC

Europe’s Vaccine Ethics Call: Do No Harm and Let More Die? – The New York Times (free registration may be required)

Related opinion: Covid-19 vaccine adverse events: balancing monitoring with confidence in vaccines – The BMJ Opinion

See also: European Medicines Agency finds AstraZeneca vaccine is safe and benefits outweigh the risks (Statement and commentaries) AND Statement of the WHO Global Advisory Committee on Vaccine Safety (GACVS) COVID-19 subcommittee on safety signals related to the AstraZeneca COVID-19 vaccine – World Health Organization AND Update on the safety of COVID-19 Vaccine AstraZeneca (statement and commentaries)

 

Commentary on Twitter

 


Recent Randomized Trials of Antithrombotic Therapy for Patients With COVID-19: JACC State-of-the-Art Review

21 Mar, 2021 | 21:49h | UTC

Recent Randomized Trials of Antithrombotic Therapy for Patients With COVID-19: JACC State-of-the-Art Review – Journal of the American College of Cardiologyv

 

Commentary on Twitter

 


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