Evidence-based Medicine
Use of pragmatic and explanatory trial designs in acute care research: lessons from COVID-19.
27 Jun, 2022 | 11:49h | UTC
Commentary on Twitter
NEW Personal View—Use of pragmatic and explanatory trial designs in acute care research: lessons from #COVID19
From Jonathan Casey & colleagues https://t.co/3vJs5j6Q1Q pic.twitter.com/hEUFYxNKRf
— The Lancet Respiratory Medicine (@LancetRespirMed) June 14, 2022
New COVID drugs face delays as trials grow more difficult.
24 Jun, 2022 | 11:47h | UTCNew COVID drugs face delays as trials grow more difficult – Nature
Research must do no harm: new guidance addresses all studies relating to people.
24 Jun, 2022 | 11:46h | UTCResearch must do no harm: new guidance addresses all studies relating to people – Nature
See Guidance: Research Ethics – Nature Portfolio
Perspective | Four areas of health innovation boosted by the pandemic.
24 Jun, 2022 | 11:36h | UTCFour areas of health innovation boosted by the pandemic – Nature Medicine
Commentary on Twitter
Leading researchers speak with @NatureMedicine about how the COVID-19 pandemic has spurred research on wearables, genomic surveillance, behavioral interventions and drug discovery. https://t.co/k3Svb0xBVB
— Nature Portfolio (@NaturePortfolio) June 17, 2022
We don’t know whether most medical treatments work, and we know even less about whether they cause harm – new study.
23 Jun, 2022 | 10:32h | UTCOriginal Study: Most healthcare interventions tested in Cochrane Reviews are not effective according to high quality evidence: a systematic review and meta-analysis – Journal of Clinical Epidemiology (link to abstract – $ for full-text)
Commentary on Twitter
Of 1567 interventions tested in Cochrane reviews, only 5.6% had high quality evidence on first-listed primary outcomes and positive, statistically significant results. Harms were measured only for 36.8% of the interventions. https://t.co/Zl2GlZhiQZ
— Raffaele Rasoini (@RasoiniR) April 29, 2022
Many researchers say they’ll share data — but don’t.
23 Jun, 2022 | 10:13h | UTCMany researchers say they’ll share data — but don’t – Nature
Supplement: Digital strategy and social media in infectious diseases.
21 Jun, 2022 | 10:22h | UTCHomepage: Digital Strategy and Social Media in Infectious Diseases – Clinical Infectious Diseases
Digital Strategy and Social Media for Infectious Diseases
The Digital Classroom: How to Leverage Social Media for Infectious Diseases Education
Educational Impact of #IDJClub, a Twitter-Based Infectious Diseases Journal Club
Surgeons, Infectious Diseases, and Twitter Hit a Home Run for Antibiotic Stewardship
Go V.I.R.A.L.: Social Media Engagement Strategies in Infectious Diseases
Perspective | Cardiovascular meta-analyses: fool’s gold or gold for fools?
20 Jun, 2022 | 01:15h | UTCCardiovascular meta-analyses: fool’s gold or gold for fools? – European Heart Journal
Approach for reporting master protocol study designs on ClinicalTrials.gov: qualitative analysis.
14 Jun, 2022 | 10:32h | UTC
Subgroup analyses in randomized clinical trials: value and limitations.
13 Jun, 2022 | 07:57h | UTC
Structured reporting to improve transparency of analyses in prognostic marker studies.
10 Jun, 2022 | 10:29h | UTCStructured reporting to improve transparency of analyses in prognostic marker studies – BMC Medicine
Sensitivity analysis in clinical trials: three criteria for a valid sensitivity analysis.
9 Jun, 2022 | 10:36h | UTCSensitivity analysis in clinical trials: three criteria for a valid sensitivity analysis – Eye
See Special Series: Research Methodology for the Ophthalmologist – Eye
‘Helicopter research’ comes under fire at Cape Town conference – statement presses for equity when scientists from wealthy nations do research in poorer ones.
8 Jun, 2022 | 11:11h | UTC‘Helicopter research’ comes under fire at Cape Town conference – Science
Do we need to reconsider how we design and conduct randomized controlled trials?
8 Jun, 2022 | 10:56h | UTC
#ADA2022 – RCT: Tirzepatide once weekly for the treatment of obesity.
6 Jun, 2022 | 11:59h | UTCTirzepatide Once Weekly for the Treatment of Obesity – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary on Twitter
SURMOUNT-1: In an RCT, adults with obesity treated with weekly tirzepatide had major weight loss over 72 weeks. #ADA2022 https://t.co/X2RrvYxzsV pic.twitter.com/X27bWp1Qod
— NEJM (@NEJM) June 4, 2022
Pivot into COVID-19 research eases as publishing surge starts to level off – Researchers who jumped into the field from distant disciplines published lower impact work, study finds.
27 May, 2022 | 12:18h | UTCPivot into COVID-19 research eases as publishing surge starts to level off – Science
Top studies of 2021 relevant to primary care.
26 May, 2022 | 10:55h | UTCTop studies of 2021 relevant to primary care: From the PEER team – Canadian Family Physician
Practical guidance to qualitative research. Part 6: Longitudinal qualitative and mixed-methods approaches for longitudinal and complex health themes in primary care research.
26 May, 2022 | 10:15h | UTCOther articles in the series:
Series: Practical guidance to qualitative research. Part 1: Introduction
Series: Practical guidance to qualitative research. Part 2: Context, research questions and designs
Series: Practical guidance to qualitative research. Part 3: Sampling, data collection and analysis
Series: Practical guidance to qualitative research. Part 4: Trustworthiness and publishing
Creating effective infographics and visual abstracts to disseminate research and facilitate medical education on social media.
24 May, 2022 | 10:46h | UTC
Commentary on Twitter
Creating Effective Infographics and Visual Abstracts to Disseminate Research and Facilitate Medical Education on Social Media
🆓 Freely Available
🔗 https://t.co/GpeoEQAWMP#IDTwitter
via @JenniferSpicer4 and @cg_coleman pic.twitter.com/DjiJbAyPVQ— Clinical Infectious Diseases (@CIDJournal) May 23, 2022
Opinion: How to pick a great scientific collaborator.
24 May, 2022 | 07:56h | UTCHow to pick a great scientific collaborator – Nature
Clinical trial registration patterns and changes in primary outcomes of randomized clinical trials from 2002 to 2017.
23 May, 2022 | 01:34h | UTCClinical Trial Registration Patterns and Changes in Primary Outcomes of Randomized Clinical Trials From 2002 to 2017 – JAMA Internal Medicine (free for a limited period)
Commentary on Twitter
This study of 146,462 full-text RCTs found that up to 32% of published trials reported a registry number, and almost 15% of these made substantial changes in primary outcome registration within study duration. Practices have improved over the years. https://t.co/JnXrEpp00J
— JAMA Internal Medicine (@JAMAInternalMed) May 17, 2022
Viewpoint: The imperative for diversity and inclusion in clinical trials and health research participation.
23 May, 2022 | 00:49h | UTC
Perspective: The need for increased pragmatism in cardiovascular clinical trials.
19 May, 2022 | 10:48h | UTCThe need for increased pragmatism in cardiovascular clinical trials – Nature Reviews Cardiology (if the link is paywalled, try this one)
Related: A roadmap of strategies to support cardiovascular researchers: from policy to practice – Nature Reviews Cardiology (if the link is paywalled, try this one)
Commentary on Twitter
In our latest Review, @ShahzebKhanMD and colleagues discuss the need for increased pragmatism in #cardiovascular clinical trials: https://t.co/LUlrPKusAk pic.twitter.com/cxAYmD2nyS
— Nature Reviews Cardiology (@NatRevCardiol) May 17, 2022
Reporting guideline for the early stage clinical evaluation of decision support systems driven by artificial intelligence: DECIDE-AI.
19 May, 2022 | 10:45h | UTC
Study designs for clinical trials applied to personalized medicine: a scoping review.
19 May, 2022 | 10:36h | UTCStudy designs for clinical trials applied to personalised medicine: a scoping review – BMJ Open