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Oncology - Gastrointestinal

RCT: Sintilimab plus a bevacizumab biosimilar versus sorafenib in unresectable hepatocellular carcinoma.

22 Jul, 2021 | 10:47h | UTC

Sintilimab plus a bevacizumab biosimilar (IBI305) versus sorafenib in unresectable hepatocellular carcinoma (ORIENT-32): a randomised, open-label, phase 2–3 study – The Lancet Oncology (link to abstract – $ for full-text)

Commentary: Sintilimab Plus Bevacizumab Biosimilar vs Sorafenib in Unresectable or Metastatic HBV-Associated Hepatocellular Carcinoma – The ASCO Post

 

Commentary on Twitter

 


AGA Clinical Practice Update on Chemoprevention for Colorectal Neoplasia.

16 Jul, 2021 | 10:46h | UTC

AGA Clinical Practice Update on Chemoprevention for Colorectal Neoplasia: Expert Review – Clinical Gastroenterology and Hepatology

 

Commentary on Twitter

 


Global burden of cancer attributable to alcohol consumption – “Globally, an estimated 741.300, or 4·1% of all new cases of cancer in 2020 were attributable to alcohol consumption”.

14 Jul, 2021 | 11:07h | UTC

Global burden of cancer in 2020 attributable to alcohol consumption: a population-based study – The Lancet Oncology

News release: Alcohol consumption linked to more than 740,000 new cancer cases in 2020 – The Lancet

Commentaries: Alcohol caused 740,000 cancer cases globally last year – study – The Guardian AND Expert reaction to study of alcohol and cancer – Science Media Centre

 


RCT: Long-term efficacy of neoadjuvant chemoradiotherapy plus surgery for the treatment of locally advanced esophageal squamous cell carcinoma.

13 Jul, 2021 | 09:20h | UTC

Long-term Efficacy of Neoadjuvant Chemoradiotherapy Plus Surgery for the Treatment of Locally Advanced Esophageal Squamous Cell Carcinoma: The NEOCRTEC5010 Randomized Clinical Trial – JAMA Surgery

Commentary: Neoadjuvant chemoradiotherapy plus surgery increases overall survival of patients with advanced esophageal squamous cell carcinoma compared to surgery alone – 2 Minute Medicine

 

Commentary on Twitter

 


Anal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.

1 Jul, 2021 | 09:44h | UTC

Anal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up – Annals of Oncology

 

Commentary on Twitter

 


Evidence-based clinical practice guidelines for management of colorectal polyps.

25 Jun, 2021 | 10:11h | UTC

Evidence-based clinical practice guidelines for management of colorectal polyps – Journal of Gastroenterology

 


RCT: Reduced-intensity chemotherapy among older and frail patients with advanced gastroesophageal cancer provides an improved patient experience with no significant detriment in cancer control.

20 May, 2021 | 08:18h | UTC

Efficacy of Reduced-Intensity Chemotherapy With Oxaliplatin and Capecitabine on Quality of Life and Cancer Control Among Older and Frail Patients With Advanced Gastroesophageal Cancer: The GO2 Phase 3 Randomized Clinical Trial – JAMA Oncology

Commentary: Lowering Chemo Dose Achieved Happier Patients, Good Outcomes in Elderly GI Cancer Patients – Physician’s Weekly

 

Commentary on Twitter

 


Randomized trial long-term results confirm the benefits of neoadjuvant chemoradiotherapy plus surgery for esophageal cancer

20 May, 2021 | 08:16h | UTC

Ten-Year Outcome of Neoadjuvant Chemoradiotherapy Plus Surgery for Esophageal Cancer: The Randomized Controlled CROSS Trial – Journal of Clinical Oncology

 

Commentaries on Twitter

 


USPSTF Statement: Start colorectal cancer screening at 45 years for most patients.

19 May, 2021 | 08:40h | UTC

Screening for Colorectal Cancer: US Preventive Services Task Force Recommendation Statement

Evidence Report: Screening for Colorectal Cancer: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force – JAMA

Editorials: US Preventive Services Task Force Recommendations for Colorectal Cancer Screening: Forty-Five Is the New Fifty – JAMA AND Updated USPSTF Guidelines for Colorectal Cancer Screening: The Earlier the Better – JAMA Surgery AND Colorectal Cancer Screening Starting at Age 45 Years—Ensuring Benefits Are Realized by All – JAMA Network Open AND

Modeling study: Colorectal Cancer Screening: An Updated Modeling Study for the US Preventive Services Task Force – JAMA

Author interview: USPSTF Recommendation: Screening for Colorectal Cancer

JAMA Patient Page: Screening for Colorectal Cancer

 


Guide to enhanced recovery for cancer patients undergoing surgery: ERAS for Patients Undergoing Cytoreductive Surgery with or Without hyperthermic intraperitoneal chemotherapy.

19 May, 2021 | 08:23h | UTC

Guide to Enhanced Recovery for Cancer Patients Undergoing Surgery: ERAS for Patients Undergoing Cytoreductive Surgery with or Without HIPEC – Annals of Surgical Oncology

Related Guidelines:

Guidelines for Perioperative Care in Cytoreductive Surgery (CRS) with or without hyperthermic IntraPEritoneal chemotherapy (HIPEC): Enhanced recovery after surgery (ERAS®) Society Recommendations — Part I: Preoperative and intraoperative management

Guidelines for Perioperative Care in Cytoreductive Surgery (CRS) with or without hyperthermic IntraPEritoneal chemotherapy (HIPEC): Enhanced Recovery After Surgery (ERAS®) Society Recommendations — Part II: Postoperative management and special considerations

See also: Enhanced Recovery After Surgery (ERAS) Society Guidelines

 


An updated review of the treatment landscape for advanced gastrointestinal stromal tumors

13 May, 2021 | 05:46h | UTC

An updated review of the treatment landscape for advanced gastrointestinal stromal tumors – Cancer

 


Case-control study shows an increased risk of colorectal cancer in first degree relatives of patients with colorectal polyps.

10 May, 2021 | 00:50h | UTC

Risk of colorectal cancer in first degree relatives of patients with colorectal polyps: nationwide case-control study in Sweden – The BMJ

Commentaries: Intestinal polyps in close relatives can increase risk of colorectal cancer – Karolinska Institutet AND Relatives’ Colonoscopy Results Could Affect Your Colon Cancer Risk – HealthDay

 

Commentary on Twitter

 


Review: Hyperthermic intraperitoneal chemotherapy for ovarian and colorectal cancer

7 May, 2021 | 08:23h | UTC

Hyperthermic Intraperitoneal Chemotherapy for Ovarian and Colorectal Cancer: A Review – JAMA Oncology (free for a limited period)

 


Cohort study: Sugar-sweetened beverage intake in adulthood and adolescence linked to increased risk of early-onset colorectal cancer among women

7 May, 2021 | 08:22h | UTC

Sugar-sweetened beverage intake in adulthood and adolescence and risk of early-onset colorectal cancer among women – Gut

Commentaries: Daily intake of two or more sugar-sweetened drinks associated with higher bowel cancer risk – BMJ AND Expert reaction to study looking at sugary drinks intake and incidence of early-onset colorectal cancer among women – Science Media Centre

 


Review: Evolution and Current Status of the Multidisciplinary Management of Locally Advanced Rectal Cancer

30 Apr, 2021 | 08:31h | UTC

Evolution and Current Status of the Multidisciplinary Management of Locally Advanced Rectal Cancer – JCO Oncology Practice

 


M-A: Helicobacter pylori eradication therapy to prevent gastric cancer – H. pylori eradication may reduce the incidence of gastric cancer in healthy individuals in East Asian countries

27 Apr, 2021 | 09:21h | UTC

Helicobacter pylori eradication therapy to prevent gastric cancer: systematic review and meta-analysis (link to abstract – $ for full-text – free article here)

 


Guide to Enhanced Recovery for Cancer Patients Undergoing Liver Surgery

25 Apr, 2021 | 20:53h | UTC

Guide to Enhanced Recovery for Cancer Patients Undergoing Liver Surgery – Annals of Surgical Oncology

See also: Guidelines for Perioperative Care for Liver Surgery: Enhanced Recovery After Surgery (ERAS) Society Recommendations – World Journal of Surgery AND Enhanced Recovery After Surgery (ERAS) Society Guidelines

 


Systematic review: Abdominal ultrasound and alpha‐foetoprotein for the diagnosis of hepatocellular carcinoma in adults with chronic liver disease

23 Apr, 2021 | 08:17h | UTC

Abdominal ultrasound and alpha‐foetoprotein for the diagnosis of hepatocellular carcinoma in adults with chronic liver disease – Cochrane Library

Summary: Abdominal ultrasound and alpha-foetoprotein for the diagnosis of hepatocellular carcinoma – Cochrane Library

 


RCT: An Enhanced Recovery After Surgery (ERAS) program in laparoscopic distal gastrectomy provided a faster recovery, a shorter postoperative hospitalization length, and lower medical costs without increasing complication and readmission rates

16 Apr, 2021 | 06:16h | UTC

Randomized Controlled Trial Comparing the Short-term Outcomes of Enhanced Recovery After Surgery and Conventional Care in Laparoscopic Distal Gastrectomy – Annals of Surgery

Related: Consensus guidelines for enhanced recovery after gastrectomy – British Journal of Surgery AND Current status of the “enhanced recovery after surgery” program in gastric cancer surgery – Annals of Gastroenterological Surgery

See also: Enhanced Recovery After Surgery (ERAS) Society Guidelines

 


RCT: Low-dose aspirin safely suppresses the recurrence of colorectal polyps in patients with familial adenomatous polyposis

14 Apr, 2021 | 01:49h | UTC

Chemoprevention with low-dose aspirin, mesalazine, or both in patients with familial adenomatous polyposis without previous colectomy (J-FAPP Study IV): a multicentre, double-blind, randomised, two-by-two factorial design trial – The Lancet Gastroenterology & Hepatology (link to abstract – $ for full-text)

 

Commentary on Twitter

 


Pancreatic cystic neoplasms: a review of current recommendations for surveillance and management

14 Apr, 2021 | 01:27h | UTC

Pancreatic cystic neoplasms: a review of current recommendations for surveillance and management – Abdominal Radiology

 


RCT: Celecoxib for 3 years added to standard adjuvant therapy does not improve disease-free survival among patients with stage III colon cancer

7 Apr, 2021 | 01:28h | UTC

Effect of Celecoxib vs Placebo Added to Standard Adjuvant Therapy on Disease-Free Survival Among Patients With Stage III Colon Cancer: The CALGB/SWOG 80702 (Alliance) Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Celecoxib for Stage III Colon Cancer – JAMA (free for a limited period)

 


M-A: Similar oncological outcomes with laparoscopic vs. open rectal cancer resections

5 Apr, 2021 | 00:43h | UTC

Oncological outcomes of laparoscopic versus open rectal cancer resections: meta-analysis of randomized clinical trials – British Journal of Surgery

 


RCT: Second-line FOLFOX chemotherapy vs. active symptom control for advanced biliary tract cancer

1 Apr, 2021 | 03:21h | UTC

Second-line FOLFOX chemotherapy versus active symptom control for advanced biliary tract cancer (ABC-06): a phase 3, open-label, randomised, controlled trial – The Lancet Oncology

Commentary: Treating patients with advanced biliary tract cancers: Changing tactics – Cancer Research UK

 


RCT: Adjuvant Nivolumab in Resected Esophageal or Gastroesophageal Junction Cancer

1 Apr, 2021 | 03:19h | UTC

Adjuvant Nivolumab in Resected Esophageal or Gastroesophageal Junction Cancer – New England Journal of Medicine (link to abstract – $ for full-text)

 


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