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Oncology – Gastrointestinal

RCT: Among patients with metastatic colorectal cancer, those randomized to systemic treatment alone had lower sixty-day mortality compared to those randomized to primary tumor resection followed by systemic treatment.

12 Oct, 2021 | 00:01h | UTC

Sixty-Day Mortality of Patients With Metastatic Colorectal Cancer Randomized to Systemic Treatment vs Primary Tumor Resection Followed by Systemic Treatment: The CAIRO4 Phase 3 Randomized Clinical Trial – JAMA Surgery (free for a limited period)

Editorial: Primary Tumor Resection and Patients With Asymptomatic Colorectal Cancer and Nonresectable Metastases: Results of Recent Randomized Trials – JAMA Surgery (free for a limited period)

Commentary: Systemic Therapy Alone Bests Surgical Tx for Metastatic CRC – BreakingMed

 

Commentary on Twitter

 

RCT: Neurolytic splanchnic nerve block and pain relief, survival, and quality of life in unresectable pancreatic cancer.

30 Sep, 2021 | 10:16h | UTC

Neurolytic Splanchnic Nerve Block and Pain Relief, Survival, and Quality of Life in Unresectable Pancreatic Cancer: A Randomized Controlled Trial – Anesthesiology

 

Commentary on Twitter

 

Gastrointestinal stromal tumors: ESMO–EURACAN–GENTURIS Clinical Practice Guidelines for diagnosis, treatment and follow-up.

30 Sep, 2021 | 10:11h | UTC

Gastrointestinal stromal tumours: ESMO–EURACAN–GENTURIS Clinical Practice Guidelines for diagnosis, treatment and follow-up – Annals of Oncology

 

State of the Art Review: Screening and prevention of colorectal cancer.

16 Sep, 2021 | 10:01h | UTC

Screening and prevention of colorectal cancer – The BMJ (free for a limited period)

Related:

USPSTF Statement: Start colorectal cancer screening at 45 years for most patients.

ACG Clinical Guidelines: Start colorectal cancer screening at 45

 

Guidelines for the surveillance and survivorship care of patients after curative treatment of colon and rectal cancer.

16 Sep, 2021 | 09:52h | UTC

The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for the Surveillance and Survivorship Care of Patients After Curative Treatment of Colon and Rectal Cancer – Diseases of the Colon & Rectum

Related: Study: Assessment of a Watch-and-Wait Strategy for Rectal Cancer in Patients With a Complete Response After Neoadjuvant Therapy

 

Commentary on Twitter

 

Consensus Guideline: Liver transplantation for non-resectable colorectal liver metastases.

16 Sep, 2021 | 09:50h | UTC

Liver transplantation for non-resectable colorectal liver metastases: the International Hepato-Pancreato-Biliary Association consensus guidelines – The Lancet Gastroenterology & Hepatology (free registration required)

 

Commentary on Twitter

 

RCT: Effect of Camrelizumab vs. placebo added to chemotherapy on survival and progression-free survival in patients with advanced or metastatic esophageal squamous cell carcinoma.

15 Sep, 2021 | 08:51h | UTC

Effect of Camrelizumab vs Placebo Added to Chemotherapy on Survival and Progression-Free Survival in Patients With Advanced or Metastatic Esophageal Squamous Cell Carcinoma: The ESCORT-1st Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Immunotherapy for Advanced Esophageal Squamous Cell Carcinoma—Renewed Enthusiasm and a Lingering Challenge – JAMA Oncology (free for a limited period)

 

Commentary on Twitter

 

Review: Cholangiocarcinoma.

10 Sep, 2021 | 05:02h | UTC

Cholangiocarcinoma – Nature Reviews Disease Primers (free for a limited period)

Infographic: Cholangiocarcinoma

 

Commentary on Twitter

 

Pancreatic Cancer: A Review.

9 Sep, 2021 | 08:51h | UTC

Pancreatic Cancer: A Review – JAMA (free for a limited period)

 

Antibiotics use is linked to increased risk of subsequent colorectal cancer.

7 Sep, 2021 | 21:25h | UTC

Antibiotics Use and Subsequent Risk of Colorectal Cancer: A Swedish Nationwide Population-Based Study – JNCI: Journal of the National Cancer Institute

Commentaries:

Antibiotics linked to increased risk of colon cancer – Umea University

Study links antibiotics use and increased subsequent risk of colorectal cancer – MedicalResearch.com

 

Pan-Asian adapted ESMO Clinical Practice Guidelines for the diagnosis treatment and follow-up of patients with localized colon cancer.

26 Aug, 2021 | 08:33h | UTC

Pan-Asian adapted ESMO Clinical Practice Guidelines for the diagnosis treatment and follow-up of patients with localised colon cancer – Annals of Oncology

 

Cohort study: Association of incomplete polyp removal with risk of postcolonoscopy colorectal cancer.

17 Aug, 2021 | 08:43h | UTC

Association of Incomplete Polyp Removal With Risk of Postcolonoscopy Colorectal Cancer – The ASCO Post

Original study: Recurrence of Colorectal Neoplastic Polyps After Incomplete Resection – Annals of Internal Medicine (link to abstract – $ for full-text)

 

Global Incidence and Mortality of Gastric Cancer, 1980-2018

13 Aug, 2021 | 08:45h | UTC

Global Incidence and Mortality of Gastric Cancer, 1980-2018 – JAMA Network Open

 

Cystic pancreatic lesions: MR imaging findings and management.

11 Aug, 2021 | 08:21h | UTC

Cystic pancreatic lesions: MR imaging findings and management – Insights into Imaging

Related:

Recommendations for the management of incidental pancreatic findings in adults.

Pancreatic cystic neoplasms: a review of current recommendations for surveillance and management

Management of Pancreatic Cystic Lesions

Consensus Recommendations: Diagnosis and Surveillance of Incidental Pancreatic Cystic Lesions

Review: Pancreatic Cystic Lesions

Guidelines on pancreatic cystic neoplasms

 

RCT: Efficacy of concurrent chemoradiotherapy with S-1 vs. radiotherapy alone for older patients with esophageal cancer.

8 Aug, 2021 | 23:35h | UTC

Efficacy of Concurrent Chemoradiotherapy With S-1 vs Radiotherapy Alone for Older Patients With Esophageal Cancer: A Multicenter Randomized Phase 3 Clinical Trial – JAMA Oncology (free for a limited period)

Editorial: Primary Chemoradiotherapy for Older Patients With Esophageal Cancer (free for a limited period)

Commentary: Concurrent CRT Effective for Esophageal Cancer in Older Patients — Overall survival at 2 years significantly better versus radiotherapy alone – MedPage Today (free registration required)

 

Commentary on Twitter

 

International consensus recommendations on key outcome measures for organ preservation after (chemo) radiotherapy in patients with rectal cancer.

5 Aug, 2021 | 08:38h | UTC

International consensus recommendations on key outcome measures for organ preservation after (chemo)radiotherapy in patients with rectal cancer – Nature Reviews Clinical Oncology

 

RCT: First-line nivolumab plus chemotherapy vs. chemotherapy alone for advanced gastric, gastro-esophageal junction, and esophageal adenocarcinoma.

3 Aug, 2021 | 02:02h | UTC

First-line nivolumab plus chemotherapy versus chemotherapy alone for advanced gastric, gastro-oesophageal junction, and oesophageal adenocarcinoma (CheckMate 649): a randomised, open-label, phase 3 trial – The Lancet (link to abstract – $ for full-text)

 

Commentary on Twitter (thread – click for more)

 

RCT: Sintilimab plus a bevacizumab biosimilar versus sorafenib in unresectable hepatocellular carcinoma.

22 Jul, 2021 | 10:47h | UTC

Sintilimab plus a bevacizumab biosimilar (IBI305) versus sorafenib in unresectable hepatocellular carcinoma (ORIENT-32): a randomised, open-label, phase 2–3 study – The Lancet Oncology (link to abstract – $ for full-text)

Commentary: Sintilimab Plus Bevacizumab Biosimilar vs Sorafenib in Unresectable or Metastatic HBV-Associated Hepatocellular Carcinoma – The ASCO Post

 

Commentary on Twitter

 

AGA Clinical Practice Update on Chemoprevention for Colorectal Neoplasia.

16 Jul, 2021 | 10:46h | UTC

AGA Clinical Practice Update on Chemoprevention for Colorectal Neoplasia: Expert Review – Clinical Gastroenterology and Hepatology

 

Commentary on Twitter

 

Global burden of cancer attributable to alcohol consumption – “Globally, an estimated 741.300, or 4·1% of all new cases of cancer in 2020 were attributable to alcohol consumption”.

14 Jul, 2021 | 11:07h | UTC

Global burden of cancer in 2020 attributable to alcohol consumption: a population-based study – The Lancet Oncology

News release: Alcohol consumption linked to more than 740,000 new cancer cases in 2020 – The Lancet

Commentaries: Alcohol caused 740,000 cancer cases globally last year – study – The Guardian AND Expert reaction to study of alcohol and cancer – Science Media Centre

 

RCT: Long-term efficacy of neoadjuvant chemoradiotherapy plus surgery for the treatment of locally advanced esophageal squamous cell carcinoma.

13 Jul, 2021 | 09:20h | UTC

Long-term Efficacy of Neoadjuvant Chemoradiotherapy Plus Surgery for the Treatment of Locally Advanced Esophageal Squamous Cell Carcinoma: The NEOCRTEC5010 Randomized Clinical Trial – JAMA Surgery

Commentary: Neoadjuvant chemoradiotherapy plus surgery increases overall survival of patients with advanced esophageal squamous cell carcinoma compared to surgery alone – 2 Minute Medicine

 

Commentary on Twitter

 

Anal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.

1 Jul, 2021 | 09:44h | UTC

Anal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up – Annals of Oncology

 

Commentary on Twitter

 

Evidence-based clinical practice guidelines for management of colorectal polyps.

25 Jun, 2021 | 10:11h | UTC

Evidence-based clinical practice guidelines for management of colorectal polyps – Journal of Gastroenterology

 

RCT: Reduced-intensity chemotherapy among older and frail patients with advanced gastroesophageal cancer provides an improved patient experience with no significant detriment in cancer control.

20 May, 2021 | 08:18h | UTC

Efficacy of Reduced-Intensity Chemotherapy With Oxaliplatin and Capecitabine on Quality of Life and Cancer Control Among Older and Frail Patients With Advanced Gastroesophageal Cancer: The GO2 Phase 3 Randomized Clinical Trial – JAMA Oncology

Commentary: Lowering Chemo Dose Achieved Happier Patients, Good Outcomes in Elderly GI Cancer Patients – Physician’s Weekly

 

Commentary on Twitter

 

Randomized trial long-term results confirm the benefits of neoadjuvant chemoradiotherapy plus surgery for esophageal cancer

20 May, 2021 | 08:16h | UTC

Ten-Year Outcome of Neoadjuvant Chemoradiotherapy Plus Surgery for Esophageal Cancer: The Randomized Controlled CROSS Trial – Journal of Clinical Oncology

 

Commentaries on Twitter

 

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