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Oncology – Gastrointestinal

RCT | First-line serplulimab or placebo plus chemotherapy in PD-L1-positive esophageal squamous cell carcinoma

3 Feb, 2023 | 14:02h | UTC

First-line serplulimab or placebo plus chemotherapy in PD-L1-positive esophageal squamous cell carcinoma: a randomized, double-blind phase 3 trial – Nature Medicine

 


M-A | Treatment- and immune-related AEs of checkpoint inhibitors in esophageal or gastroesophageal junction cancer

3 Feb, 2023 | 13:55h | UTC

Treatment- and immune-related adverse events of immune checkpoint inhibitors in esophageal or gastroesophageal junction cancer: A network meta-analysis of randomized controlled trials – Frontiers in Oncology

 


M-A | Major complications and mortality after resection of intrahepatic cholangiocarcinoma

3 Feb, 2023 | 13:43h | UTC

Major complications and mortality after resection of intrahepatic cholangiocarcinoma: A systematic review and meta-analysis – Surgery

 


M-A | Short-and long-term outcomes of laparoscopic versus open gastrectomy in patients with gastric cancer

2 Feb, 2023 | 14:36h | UTC

Short-and long-term outcomes of laparoscopic versus open gastrectomy in patients with gastric cancer: a systematic review and meta-analysis of randomized controlled trials – World Journal of Surgical Oncology

 


M-A | Immunotherapy or targeted therapy as the first-line strategies for unresectable hepatocellular carcinoma

31 Jan, 2023 | 13:42h | UTC

Immunotherapy or targeted therapy as the first-line strategies for unresectable hepatocellular carcinoma: A network meta-analysis and cost-effectiveness analysis – Frontiers in Immunology

 


Cohort Study | Risk of malignant neoplasms of the gastrointestinal tract after blood or marrow transplant

30 Jan, 2023 | 00:23h | UTC

Malignant Neoplasms of the Gastrointestinal Tract After Blood or Marrow Transplant – JAMA Oncology (link to abstract – $ for full-text)

Commentary: Risk of Subsequent Gastrointestinal Tract Malignancies After Blood or Marrow Transplantation – The ASCO Post

 

Commentary on Twitter

 


M-A | Proximal gastrectomy with double-tract-reconstruction vs. total gastrectomy in gastric and gastroesophageal junction cancer patients

27 Jan, 2023 | 11:54h | UTC

Systematic review and meta-analysis comparing proximal gastrectomy with double-tract-reconstruction and total gastrectomy in gastric and gastroesophageal junction cancer patients: Still no sufficient evidence for clinical decision-making – Surgery

 


RCT | Postoperative adjuvant hepatic arterial infusion chemotherapy with FOLFOX in hepatocellular carcinoma with microvascular invasion

26 Jan, 2023 | 12:03h | UTC

Postoperative Adjuvant Hepatic Arterial Infusion Chemotherapy With FOLFOX in Hepatocellular Carcinoma With Microvascular Invasion: A Multicenter, Phase III, Randomized Study – Journal of Clinical Oncology

 


RCT | Preoperative chemotherapy reduced recurrence in operable colon cancer

25 Jan, 2023 | 11:29h | UTC

Preoperative Chemotherapy for Operable Colon Cancer: Mature Results of an International Randomized Controlled Trial – Journal of Clinical Oncology

Editorial: FOxTROT: Are We Ready to Dance? – Journal of Clinical Oncology

News Release: Chemotherapy before surgery cuts risk of colon cancer returning, trial finds – Cancer Research UK

Commentary: New treatment strategy cuts risk of bowel cancer returning by 28% – The Guardian

 

Commentary from one of the authors on Twitter (thread – click for more)

 


Cohort Study | Prevalence of colorectal neoplasia 10 or more years after a negative screening colonoscopy in 120 000 repeated screening colonoscopies

23 Jan, 2023 | 13:36h | UTC

Prevalence of Colorectal Neoplasia 10 or More Years After a Negative Screening Colonoscopy in 120 000 Repeated Screening Colonoscopies – JAMA Internal Medicine

Commentaries:

Prevalence of Colorectal Cancers Low 10 Years Following Negative Screening Test – HCP Live

Risk for Advanced Neoplasm Low 10+ Years After Negative Colonoscopy – HealthDay

 

Commentary on Twitter

 


RCT | Adjuvant S-1 compared with observation in resected biliary tract cancer

23 Jan, 2023 | 13:24h | UTC

Adjuvant S-1 compared with observation in resected biliary tract cancer (JCOG1202, ASCOT): a multicentre, open-label, randomised, controlled, phase 3 trial – The Lancet (link to abstract – $ for full-text)

 

Commentary on Twitter

 


Single-arm phase 2 study | Futibatinib for FGFR2-rearranged intrahepatic cholangiocarcinoma

23 Jan, 2023 | 13:22h | UTC

Futibatinib for FGFR2-Rearranged Intrahepatic Cholangiocarcinoma – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Futibatinib in Previously Treated Patients With Advanced FGFR2-Rearranged Intrahepatic Cholangiocarcinoma – ASCO Post

 

Commentary on Twitter

 


Cohort Study | Hemicolectomy vs. appendectomy for patients with appendiceal neuroendocrine tumors 1–2 cm in size

23 Jan, 2023 | 13:21h | UTC

Hemicolectomy versus appendectomy for patients with appendiceal neuroendocrine tumours 1–2 cm in size: a retrospective, Europe-wide, pooled cohort study – The Lancet Oncology (link to abstract – $ for full-text)

Commentary: Appendectomy With or Without Hemicolectomy for 1- to 2-cm Appendiceal Neuroendocrine Tumors – The ASCO Post

 


MRI anatomy of the rectum: key concepts important for rectal cancer staging and treatment planning

20 Jan, 2023 | 14:34h | UTC

MRI anatomy of the rectum: key concepts important for rectal cancer staging and treatment planning – Insights into Imaging

 


Single-arm phase 1-2 study | Sotorasib in KRAS p.G12C–mutated advanced pancreatic cancer

20 Jan, 2023 | 14:31h | UTC

Sotorasib in KRAS p.G12C–Mutated Advanced Pancreatic Cancer – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Sotorasib Shows Clinically Meaningful Activity Among Patients With KRAS G12C–Mutated Advanced Pancreatic Cancer – The ASCO Post

 

Commentary on Twitter

 


RCT | Effect of interval between neoadjuvant chemoradiotherapy and surgery on disease recurrence and survival in rectal cancer

20 Jan, 2023 | 14:19h | UTC

Effect of interval between neoadjuvant chemoradiotherapy and surgery on disease recurrence and survival in rectal cancer: long-term results of a randomized clinical trial – BJS Open

 

Commentary on Twitter

 


Study shows patients with circulating tumor DNA are at increased risk of relapse after surgery for resectable colorectal cancer

19 Jan, 2023 | 14:18h | UTC

Molecular residual disease and efficacy of adjuvant chemotherapy in patients with colorectal cancer – Nature Medicine – Nature Medicine

Commentary: Data Support ctDNA as a Prognostic Marker for Recurrence/Benefit in Colorectal Cancer – Cancer Network

 

Commentary on Twitter

 


Consensus Paper | Management of early-onset colorectal cancer

19 Jan, 2023 | 14:14h | UTC

Delphi initiative for early-onset colorectal cancer (DIRECt). International Management Guidelines – Clinical Gastroenterology and Hepatology

 


ACG Clinical Guideline | Diagnosis and management of gastrointestinal subepithelial lesions

18 Jan, 2023 | 14:39h | UTC

ACG Clinical Guideline: Diagnosis and Management of Gastrointestinal Subepithelial Lesions – The American Journal of Gastroenterology

Related: AGA Clinical Practice Update on Management of Subepithelial Lesions Encountered During Routine Endoscopy: Expert Review – Clinical Gastroenterology and Hepatology

 


M-A | Does neoadjuvant treatment in resectable pancreatic cancer improve overall survival?

17 Jan, 2023 | 13:07h | UTC

Does neoadjuvant treatment in resectable pancreatic cancer improve overall survival? A systematic review and meta-analysis of randomized controlled trials – ESMO Open

 


RCT | Adjuvant nab-Paclitaxel + Gemcitabine in resected pancreatic ductal adenocarcinoma

10 Jan, 2023 | 14:13h | UTC

Adjuvant nab-Paclitaxel + Gemcitabine in Resected Pancreatic Ductal Adenocarcinoma: Results From a Randomized, Open-Label, Phase III Trial – Journal of Clinical Oncology

 


RCT | Neoadjuvant chemotherapy with CAPOX vs. chemoradiation for locally advanced rectal cancer with uninvolved mesorectal fascia

10 Jan, 2023 | 14:09h | UTC

Neoadjuvant Chemotherapy with CAPOX versus Chemoradiation for Locally Advanced Rectal Cancer with Uninvolved Mesorectal Fascia (CONVERT): Initial Results of a Phase III Trial – Annals of Surgery

 


ASCO Guideline | Immunotherapy and targeted therapy for advanced gastroesophageal cancer

9 Jan, 2023 | 14:40h | UTC

Immunotherapy and Targeted Therapy for Advanced Gastroesophageal Cancer: ASCO Guideline – Journal of Clinical Oncology

News Release: First ASCO Guideline for Immunotherapy and Targeted Therapy in Advanced Gastroesophageal Cancer Now Available – ASCO Daily News

 


Phase 1-2 study | Adagrasib with or without Cetuximab in colorectal cancer with mutated KRAS G12C

9 Jan, 2023 | 14:04h | UTC

Adagrasib with or without Cetuximab in Colorectal Cancer with Mutated KRAS G12C – New England Journal of Medicine (link to abstract – $ for full-text)

News Release: Advanced Colorectal Cancer Treatment Targets KRAS Gene With Drug Combo – Memorial Sloan Kettering Cancer Center

 

Commentary on Twitter

 


M-A | Laparoscopic vs. open pancreatoduodenectomy in patients with periampullary tumors

9 Jan, 2023 | 14:02h | UTC

Laparoscopic versus Open Pancreatoduodenectomy in Patients with Periampullary Tumors: A Systematic Review and Meta-analysis – Annals of Surgery (link to abstract – $ for full-text)

Related: Comparison of safety and effectiveness between laparoscopic and open pancreatoduodenectomy: A systematic review and meta-analysis – International Journal of Surgery

 


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