Gastrointestinal Surgery
Role of imaging in visceral vascular emergencies
20 Jan, 2021 | 01:14h | UTCRole of imaging in visceral vascular emergencies – Insights into Imaging
Postsurgical disease recurrence in stage I to III colorectal cancer may be predicted by ctDNA
20 Jan, 2021 | 01:07h | UTCCommentaries: Postsurgical Disease Recurrence in Stage I to III Colorectal Cancer May Be Predicted by ctDNA – The ASCO Post AND Liquid Biopsy Predicts Colon Cancer Relapse Months Before CT – MedPage Today (free registration required)
Study: Similar length of hospital stay with laparoscopic vs. open gastrectomy for gastric cancer
20 Jan, 2021 | 01:05h | UTCLength of Hospital Stay With Laparoscopic vs Open Gastrectomy for Gastric Cancer – The ASCO Post
Randomized trial: Prevention of biliary fistula after partial hepatectomy by transcystic biliary drainage
19 Jan, 2021 | 01:19h | UTCPrevention of biliary fistula after partial hepatectomy by transcystic biliary drainage: randomized clinical trial – British Journal of Surgery (link to abstract – $ for full-text)
Randomized trial: Pneumatic dilation does not work for persistent dysphagia after antireflux surgery
19 Jan, 2021 | 01:13h | UTCPneumatic dilation for persistent dysphagia after antireflux surgery, a multicentre single-blind randomised sham-controlled clinical trial – Gut (link to abstract – $ for full-text)
Systematic review: The association of Alvimopan treatment with postoperative outcomes after abdominal surgery
19 Jan, 2021 | 01:05h | UTCThe association of alvimopan treatment with postoperative outcomes after abdominal surgery: A systematic review across different surgical procedures and contexts of perioperative care – Surgery (link to abstract – $ for full-text)
Meta-analysis of observational studies: Proton pump inhibitors linked to increased risk for recurrent Clostridioides difficile infection
17 Jan, 2021 | 22:00h | UTC
Postdischarge virtual visits for low-risk surgeries: A randomized noninferiority clinical trial
17 Jan, 2021 | 21:57h | UTCPostdischarge Virtual Visits for Low-risk Surgeries: A Randomized Noninferiority Clinical Trial – JAMA Surgery (free for a limited period)
Commentary: Surgical Centers Warm Up to Video Chats, Texts for Patient Follow-Up – MedPage Today (free registration required)
Randomized trial: Biological mesh results in significantly more complications compared to synthetic mesh in noncomplex ventral hernia repair
15 Jan, 2021 | 08:17h | UTCSynthetic Versus Biological Mesh in Laparoscopic and Open Ventral Hernia Repair (LAPSIS): Results of a Multinational, Randomized, Controlled, and Double-blind Trial – Annals of Surgery (link to abstract – $ for full-text)
Commentary on Twitter
The use of biological mesh resulted in significantly more complications (P = 0.013),also after adjusting for hernia type, body mass index,and study site.The trial was prematurely stopped due to unacceptable high recurrence rate in the biological mesh arms https://t.co/P0fV50xopv
— George Ferzli (@drferzli) December 25, 2020
Antibiotics alone for uncomplicated appendicitis: Oral Moxifloxacin almost as good as intravenous Ertapenem + oral Levofloxacin
14 Jan, 2021 | 01:57h | UTCEditorial: Evolving Issues in the Use of Antibiotics for the Treatment of Uncomplicated Appendicitis
Commentary: More Support for Single-Drug Antibiotics for Uncomplicated Appendicitis – Physician’s Weekly
Commentary on Twitter
In this RCT comparing 7d oral moxifloxacin vs 2d IV ertapenam 5d oral levofloxacin metronidazole for adults w uncomplicated #appendicitis, Tx success was >65% for both, but oral #antibiotics did not meet noninferiority criteria vs IV PO https://t.co/SwcopsGZTm #VisualAbstract
— JAMA (@JAMA_current) January 12, 2021
Meta-analysis of mortality risk in octogenarians undergoing emergency general surgery operations
14 Jan, 2021 | 01:36h | UTCMeta-analysis of mortality risk in octogenarians undergoing emergency general surgery operations – Surgery (link to abstract – $ for full-text)
[Abstract Only] Meta-Analysis: Not enough evidence to recommend the use of a prosthetic Mesh for prevention of parastomal hernia
12 Jan, 2021 | 01:18h | UTCMeta-Analysis and Systematic Review of the Use of a Prosthetic Mesh for Prevention of Parastomal Hernia – Annals of Surgery (link to abstract – $ for full-text)
Randomized trial: Short-course radiotherapy followed by chemotherapy before total mesorectal excision (TME) improve outcomes vs. traditional approach in locally advanced rectal cancer
12 Jan, 2021 | 01:12h | UTCShort-course radiotherapy followed by chemotherapy before total mesorectal excision (TME) versus preoperative chemoradiotherapy, TME, and optional adjuvant chemotherapy in locally advanced rectal cancer (RAPIDO): a randomised, open-label, phase 3 trial – The Lancet Oncology (link to abstract – $ for full-text)
Commentary on Twitter
New online: phase 3 RAPIDO trial: Short-course #radiotherapy followed by #chemotherapy before total mesorectal excision (TME) vs standard of care in locally advanced #rectalcancer https://t.co/bTgUC6Lo39 #crcsm pic.twitter.com/Iu3HbQ1xjG
— The Lancet Oncology (@TheLancetOncol) December 8, 2020
Study suggests the intensity of active surveillance in patients with rectal cancer managed by a watch-and-wait approach could be reduced if they maintain a complete clinical response within the first 3 years
12 Jan, 2021 | 01:11h | UTCCommentaries: Rectal cancer patients who “watch and wait” may only need few years of stringent follow-up – eCancer AND Intense rectal cancer surveillance may be reduced – MDedge
Meta-analysis: Total neoadjuvant therapy vs. standard therapy in locally advanced rectal cancer
12 Jan, 2021 | 01:10h | UTCCommentaries: Personalizing Treatment for Rectal Cancer: Total Neoadjuvant Therapy Is Leading the Way AND Total Neoadjuvant Therapy Improves Rectal Cancer Pathologic Response – Physician’s Weekly
Related meta-analysis (just published): Impact of Total Neoadjuvant Therapy vs. Standard Chemoradiotherapy in Locally Advanced Rectal Cancer: A Systematic Review and Meta-Analysis of Randomized Trials – Cancers
Commentary on Twitter
Systematic review & meta-analysis finds total neoadjuvant therapy for locally adv. rectal cancer is associated with a doubling of pathologic complete response vs standard chemoradiation plus by adjuvant chemo. @anup_kasi @KUMedCenter @geriradonc @agrothey https://t.co/oRccCh5bEb
— JAMA Network Open (@JAMANetworkOpen) December 16, 2020
Randomized trial: Laparoscopic lavage vs. primary resection for perforated purulent diverticulitis; similar long-term results, but recurrence was more common after laparoscopic lavage
10 Jan, 2021 | 20:25h | UTCLaparoscopic Lavage vs Primary Resection for Acute Perforated Diverticulitis: Long-term Outcomes From the Scandinavian Diverticulitis (SCANDIV) Randomized Clinical Trial – JAMA Surgery (link to abstract – $ for full-text)
Commentary: Laparoscopic Lavage a Safe Option in Perforated Diverticulitis — No difference versus resection in long-term severe complications, but recurrence more common – MedPage Today (free registration required)
Randomized trial: In surgical patients at moderate or high risk of venous thromboembolism, pharmaco-thromboprophylaxis alone is as good as the combination of pharmaco-thromboprophylaxis and graduated compression stockings
16 Dec, 2020 | 10:00h | UTC
Randomized trial: Extensive peritoneal lavage with saline after curative gastrectomy for gastric cancer does not benefit patients vs. surgery alone
16 Dec, 2020 | 09:55h | UTCExtensive peritoneal lavage with saline after curative gastrectomy for gastric cancer (EXPEL): a multicentre randomised controlled trial – The Lancet Gastroenterology & Hepatology (link to abstract – $ for full-text)
Commentary on Twitter
ICYMI – Results of the EXPEL trial show no survival benefit with extensive peritoneal #lavage after surgery vs surgery alone; not recommended for patients undergoing curative #gastrectomy for #gastriccancer.https://t.co/rCgHNt7VZ1#gitwitter #some4surgery pic.twitter.com/BC1BJgElYm
— The Lancet Gastroenterology & Hepatology (@LancetGastroHep) December 9, 2020
Randomized trial: Among patients with advanced rectal cancer, short-course radiotherapy followed by chemotherapy before total mesorectal excision reduces disease-related treatment failure compared to standard treatment
15 Dec, 2020 | 01:29h | UTC
Commentary on Twitter
New online: phase 3 RAPIDO trial: Short-course #radiotherapy followed by #chemotherapy before total mesorectal excision (TME) vs standard of care in locally advanced #rectalcancer https://t.co/bTgUC6Lo39 #crcsm pic.twitter.com/Iu3HbQ1xjG
— The Lancet Oncology (@TheLancetOncol) December 8, 2020
Randomized trial: No difference in quality of life and slightly greater weight loss with Roux-en-Y Gastric Bypass compared to Laparoscopic Sleeve Gastrectomy at 7 years
11 Dec, 2020 | 09:20h | UTCEffect of Laparoscopic Sleeve Gastrectomy vs Roux-en-Y Gastric Bypass on Weight Loss and Quality of Life at 7 Years in Patients With Morbid Obesity: The SLEEVEPASS Randomized Clinical Trial – JAMA Surgery (free for a limited period)
Commentary: Using Quality-of-Life Measures to Determine the Ideal Bariatric Procedure – JAMA Surgery (free for a limited period)
Systematic Review: Probiotics probably make little or no difference for patients with acute infectious diarrhea
10 Dec, 2020 | 08:53h | UTCProbiotics for treating acute infectious diarrhoea – Cochrane Library
Summary: Do probiotics help to treat acute infectious diarrhoea? – Cochrane Library
Randomized trial: In patients with recurrent, complicated, or persistent painful diverticulitis, sigmoid resection improved quality of life but was associated with a small but significant risk of major complications
10 Dec, 2020 | 08:51h | UTCAuthor Interview: Laparoscopic Sigmoid Resection vs Conservative Treatment in Improving Quality of Life in Diverticulitis
Commentary on Twitter
In this randomized clinical trial, elective laparoscopic sigmoid resection improved quality of life in patients with recurrent, complicated, or persistent painful diverticulitis but carried a 10% risk of major complications. https://t.co/K7yZqmCP5J
— George Ferzli (@drferzli) November 23, 2020
Review: Perioperative venous thromboembolism prophylaxis
3 Dec, 2020 | 08:28h | UTCPerioperative Venous Thromboembolism Prophylaxis – Mayo Clinic Proceedings
State of the art review: Advances in the diagnosis and management of gastroesophageal reflux disease
30 Nov, 2020 | 00:52h | UTCAdvances in the diagnosis and management of gastroesophageal reflux disease – The BMJ (free for a limited period)
Randomized trial: Colorectal cancer screening with repeated fecal immunochemical tests detects more colorectal cancer and advanced adenomas compared to screening sigmoidoscopy
25 Nov, 2020 | 09:05h | UTCColorectal cancer screening with repeated fecal immunochemical test versus sigmoidoscopy: baseline results from a randomized trial – Gastroenterology (link to abstract – $ for full-text)