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Pediatrics – Allergy and Immunology

RCT | Peanut patch therapy is effective in desensitizing young children with allergies, but raises risk of serious adverse events

15 May, 2023 | 13:10h | UTC

Phase 3 Trial of Epicutaneous Immunotherapy in Toddlers with Peanut Allergy – New England Journal of Medicine (link to abstract – $ for full-text)

 

Commentary on Twitter

 

M-A | Timing of allergenic food introduction and risk of immunoglobulin E–mediated food allergy

11 Apr, 2023 | 14:32h | UTC

Timing of Allergenic Food Introduction and Risk of Immunoglobulin E–Mediated Food Allergy: A Systematic Review and Meta-analysis – JAMA Pediatrics

News Release: Earlier introduction of allergenic foods in children may prevent food allergies – Imperial College London

Commentary: Allergenic Food Introduction Led to Fewer Allergies, Higher Withdrawal Rate from Intervention – HCP Live

Related:

Study | Public health policies should recommend introducing peanut products to infants at 4-6 months of age to prevent peanut allergy

AAP Updated Recommendations for Dietary Interventions to Prevent Atopic Disease

Timing of introduction of allergenic solids for infants at high risk – Canadian Paediatric Society

 

Commentary on Twitter

 

Cohort Study | Associations between fetal or infancy pet exposure and food allergies

3 Apr, 2023 | 13:26h | UTC

Associations between fetal or infancy pet exposure and food allergies: The Japan Environment and Children’s Study – PLOS One

 

Two phase 3 trials of lebrikizumab for moderate-to-severe atopic dermatitis

21 Mar, 2023 | 13:23h | UTC

Two Phase 3 Trials of Lebrikizumab for Moderate-to-Severe Atopic Dermatitis – New England Journal of Medicine (link to abstract – $ for full-text)

News Release: Largest study to date of lebrikizumab supports its use for treatment of atopic dermatitis – George Washington University

Commentary: Lebrikizumab Effective for Adults, Teens With Atopic Dermatitis – HealthDay

 

Study | Public health policies should recommend introducing peanut products to infants at 4-6 months of age to prevent peanut allergy

20 Mar, 2023 | 13:33h | UTC

Defining the window of opportunity and target populations to prevent peanut allergy – Journal of Allergy and Clinical Immunology

Commentary: Expert reaction to research on giving peanut products to babies – Science Media Centre

Related study: Early Introduction of Allergenic Foods Can Prevent Food Allergies in High Risk Infants

Related Guidelines: 

AAP Updated Recommendations for Dietary Interventions to Prevent Atopic Disease

Timing of introduction of allergenic solids for infants at high risk – Canadian Paediatric Society

 

Commentary from the author on Twitter

 

RCT | Methylprednisolone vs. immunoglobulins equally effective in PIMS temporally associated with SARS-CoV-2

8 Feb, 2023 | 12:42h | UTC

Methylprednisolone versus intravenous immunoglobulins in children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS): an open-label, multicentre, randomised trial – The Lancet Child & Adolescent Health

 

SR | Skin care interventions in infants for preventing eczema and food allergy.

12 Dec, 2022 | 12:23h | UTC

Skin care interventions in infants for preventing eczema and food allergy – Cochrane Library

Summary: Skin care interventions for preventing eczema and food allergy – Cochrane Library

 

Commentary on Twitter

 

RCT | Dupilumab in children aged 6 months to younger than 6 years with uncontrolled atopic dermatitis.

20 Sep, 2022 | 13:20h | UTC

Dupilumab in children aged 6 months to younger than 6 years with uncontrolled atopic dermatitis: a randomised, double-blind, placebo-controlled, phase 3 trial – The Lancet

Commentary: Dupilumab Eases Atopic Dermatitis in Children Younger Than 6 Years – HealthDay

 

Systematic Review | Anti‐IL‐5 therapies for asthma.

14 Jul, 2022 | 12:40h | UTC

Anti‐IL‐5 therapies for asthma – Cochrane Library

Summary: Mepolizumab, reslizumab or benralizumab for people already taking inhaled steroids and long-acting beta 2-agonists for their asthma – Cochrane Library

 

Review: Management of moderate-severe atopic dermatitis in pediatric age.

27 Jun, 2022 | 11:32h | UTC

Narrative review on the management of moderate-severe atopic dermatitis in pediatric age of the Italian Society of Pediatric Allergology and Immunology (SIAIP), of the Italian Society of Pediatric Dermatology (SIDerP) and of the Italian Society of Pediatrics (SIP) – Italian Journal of Pediatrics

 

EULAR/ACR points to consider for diagnosis, management and monitoring of the interleukin-1 mediated autoinflammatory diseases.

24 Jun, 2022 | 11:23h | UTC

The 2021 EULAR/American College of Rheumatology points to consider for diagnosis, management and monitoring of the interleukin-1 mediated autoinflammatory diseases: cryopyrin-associated periodic syndromes, tumour necrosis factor receptor-associated periodic syndrome, mevalonate kinase deficiency, and deficiency of the interleukin-1 receptor antagonist – Annals of Rheumatic Diseases

 

RCT: Effectiveness and safety of lotion, cream, gel, and ointment emollients for childhood eczema.

15 Jun, 2022 | 11:20h | UTC

Effectiveness and safety of lotion, cream, gel, and ointment emollients for childhood eczema: a pragmatic, randomised, phase 4, superiority trial – The Lancet Child & Adolescent Health

News Release: The right moisturiser for children with eczema is the one that they like to use, study finds – University of Nottingham

Commentary: Lotion, Cream, Gel, and Ointment Similarly Effective for Childhood Eczema – HealthDay

 

Commentary on Twitter

 

M-A: Reproducibility of food challenge to cow’s milk.

15 Jun, 2022 | 10:42h | UTC

Reproducibility of food challenge to cow’s milk: a systematic review with individual participant data meta-analysis – Journal of Allergy and Clinical Immunology

 

Position Paper: Diagnostic therapeutic care pathway for pediatric food allergies and intolerances.

14 Jun, 2022 | 11:05h | UTC

Diagnostic therapeutic care pathway for pediatric food allergies and intolerances in Italy: a joint position paper by the Italian Society for Pediatric Gastroenterology Hepatology and Nutrition (SIGENP) and the Italian Society for Pediatric Allergy and Immunology (SIAIP) – Italian Journal of Pediatrics

 

Another study suggests the Omicron variant is associated with a reduced risk of Multisystem Inflammatory Syndrome in Children compared to previous SARS-CoV-2 variants.

10 Jun, 2022 | 12:38h | UTC

Risk and Phenotype of Multisystem Inflammatory Syndrome in Vaccinated and Unvaccinated Danish Children Before and During the Omicron Wave – JAMA Pediatrics

Related study: Severity and Incidence of Multisystem Inflammatory Syndrome in Children During 3 SARS-CoV-2 Pandemic Waves in Israel – JAMA AND Commentary: Kids’ COVID syndrome—MIS-C—less severe in Omicron – CIDRAP

 

Commentary on Twitter

 

Consensus on the diagnosis and treatment of cow’s milk protein allergy.

2 Jun, 2022 | 10:56h | UTC

Consensus on the diagnosis and treatment of cow’s milk protein allergy of the Latin American Society for Pediatric Gastroenterology, Hepatology and Nutrition – Revista de Gastroenterología de México (English Edition)

 

Cohort Study: Most egg allergy and nearly one-third of peanut allergy resolves naturally by age 6 years.

27 May, 2022 | 11:46h | UTC

The natural history of peanut and egg allergy in children up to age 6 years in the HealthNuts population-based longitudinal study – The Journal of Allergy & Clinical Immunology (link to abstract – $ for full-text)

 

Joint consensus guidelines on the diagnosis and management of eosinophilic esophagitis in children and adults.

25 May, 2022 | 11:32h | UTC

British Society of Gastroenterology (BSG) and British Society of Paediatric Gastroenterology, Hepatology and Nutrition (BSPGHAN) joint consensus guidelines on the diagnosis and management of eosinophilic oesophagitis in children and adults – Gut

 

Guideline: Contact dermatitis.

10 May, 2022 | 10:54h | UTC

German S1 guideline: Contact dermatitis – Journal of the German Society of Dermatology

 

Analysis of an intervention for emergency medical services personnel to reduce epinephrine dosing errors in infants.

19 Apr, 2022 | 01:52h | UTC

Analysis of an Intervention for Emergency Medical Services Personnel to Reduce Epinephrine Dosing Errors in Infants – JAMA Network Open

 

Commentary on Twitter

 

Cohort Study: Predictors of severe illness in children with multisystem inflammatory syndrome after SARS-CoV-2 infection.

12 Apr, 2022 | 09:57h | UTC

Predictors of severe illness in children with multisystem inflammatory syndrome after SARS-CoV-2 infection: a multicentre cohort study – Canadian Medical Association Journal

News Release: Children older than 5 at higher risk of COVID-19-related multisystem inflammatory syndrome – Canadian Medical Association Journal

Commentary: Older Kids More Vulnerable to MIS-C: Study – HealthDay

 

Translating research into practice: What’s new in the 2021 EAACI food allergy prevention guidelines?

8 Apr, 2022 | 10:00h | UTC

Translating research into practice: What’s new in the 2021 EAACI food allergy prevention guidelines? – Clinical & Experimental Allergy

Original Guideline: EAACI guideline: Preventing the development of food allergy in infants and young children – Pediatric Allergy and Immunology

Related:

Practice Guideline: Prevention and management of allergic reactions to food in child care centers and schools

Study: Early Introduction of Allergenic Foods Can Prevent Food Allergies in High Risk Infants

AAP Updated Recommendations for Dietary Interventions to Prevent Atopic Disease

Timing of introduction of allergenic solids for infants at high risk – Canadian Paediatric Society (free)

Short Review: Food Allergy Prevention with Early Food Introduction

 

Cohort Study: Short-term outcomes of corticosteroid monotherapy in multisystem inflammatory syndrome in children.

30 Mar, 2022 | 10:40h | UTC

Short-term Outcomes of Corticosteroid Monotherapy in Multisystem Inflammatory Syndrome in Children – JAMA Pediatrics

 

Commentary on Twitter

 

Cohort Study: Prenatal occupational disinfectant exposure linked to increased risk of childhood allergies.

30 Mar, 2022 | 08:48h | UTC

Prenatal occupational disinfectant exposure and childhood allergies: the Japan Environment and Children’s study – Occupational & Environmental Medicine

Commentary: Disinfectant use by pregnant women may increase risk for asthma and eczema in children – BMJ/News Medical

 

Commentary on Twitter

 

The prevalence of penicillin allergy labeling ranged from 0.9% to 10.2% across practices in a large pediatric cohort, raising questions regarding the validity of those labels and the unnecessary use of second-line antibiotics that may follow.

28 Mar, 2022 | 09:48h | UTC

Factors Associated With Penicillin Allergy Labels in Electronic Health Records of Children in 2 Large US Pediatric Primary Care Networks – JAMA Network Open

Related: A pharmacist-led penicillin allergy assessment program can delabel many “penicillin allergic” patients through allergy histories and penicillin skin testing. The program was associated with reduced use of high Clostridioides difficile infection–risk antibiotics.

M-A: Most patients with allergy to Penicillin can be given Cefazolin

Systematic review: Safety and efficacy of de-labelling penicillin allergy in adults using direct oral challenge

Penicillin allergy labels increase second-line broad-spectrum antibiotic prescribing for pediatric respiratory tract infections

Podcast: A Clinical Pharmacologist’s Perspective on Penicillin Allergy

Study: Development and Validation of a Penicillin Allergy Clinical Decision Rule

Consensus Recommendations: Management of a Surgical Patient with a Label of Penicillin Allergy

Practical Guide for Pharmacists to Successfully Implement Penicillin Allergy Skin Testing

NICE: Double Check Patients with ‘Penicillin Allergy’ to Avoid Increased MRSA Risk

Cohort Study: Risk of Meticillin Resistant Staphylococcus Aureus and Clostridium Difficile in Patients with a Documented Penicillin Allergy

 

Commentary on Twitter

 

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