Fertility/Reproductive Medicine
RCT | Prednisone fails to enhance live birth outcomes in women with recurrent implantation failure
5 May, 2023 | 15:31h | UTCPrednisone vs Placebo and Live Birth in Patients With Recurrent Implantation Failure Undergoing In Vitro Fertilization: A Randomized Clinical Trial – JAMA (free for a limited period)
See also: Visual Abstract
WHO Report | 1 in 6 people globally affected by infertility
5 Apr, 2023 | 13:47h | UTCNews Release: 1 in 6 people globally affected by infertility – World Health Organization
Report: Infertility Prevalence Estimates, 1990–2021 – World Health Organization
Key facts: Infertility – World Health Organization
Commentaries:
Infertility affects a ‘staggering’ 1 in 6 people worldwide, WHO says – CNN
One in six people worldwide affected by infertility, WHO reports – The Guardian
Commentary on Twitter (thread – click for more)
Around 1 in 6 people is affected by infertility in their lifetime: 🆕 WHO research.
This shows an urgent need to increase access to affordable, high-quality fertility care https://t.co/od9QQ9Qjvj pic.twitter.com/R8JtezT0kZ
— World Health Organization (WHO) (@WHO) April 4, 2023
Study shows there is little evidence of heightened pregnancy risks for IVF-conceived parents
24 Mar, 2023 | 12:53h | UTCNews Release: Little evidence that IVF conception heightens future pregnancy risks – BMJ Newsroom
Cohort Study | Infertility in women linked to increased risk of cardiovascular disease
23 Mar, 2023 | 12:39h | UTC
Commentary on Twitter
Women with infertility may have greater risk of #coronary #heart #disease, especially those diagnosed with #ovulation disorders/#endometriosis. #AHAJournals #GoRedforWomen @l_farland https://t.co/Izaloav4Np pic.twitter.com/Iqn4eQexJL
— JAHA (@JAHA_AHA) February 27, 2023
Cohort Study | IVF-conceived children have similar school-age educational outcomes as spontaneously conceived children
2 Mar, 2023 | 12:53h | UTCSchool-age outcomes among IVF-conceived children: A population-wide cohort study – PLOS Medicine
News Release: No link between IVF-assisted conception and school-age childhood development outcomes, study says – University of Melborn
Commentary: IVF Not Tied to Worse Developmental, Educational Outcomes – HealthDay
Registry of the international society of uterus transplantation: first report
24 Feb, 2023 | 13:29h | UTCRegistry of the International Society of Uterus Transplantation: First Report – Transplantation
Development of a model to estimate the optimal number of oocytes to attempt to fertilize in IVF
14 Feb, 2023 | 10:36h | UTC
Commentary on Twitter
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2799935
Stillbirth after adolescent and young adult cancer: a population-based study
14 Feb, 2023 | 10:33h | UTCCommentary: Previous Cancer Treatment Not Tied to Higher Stillbirth Rate – HealthDay
RCT | Routine use of endometrial receptivity testing to guide the timing of frozen embryo transfer did not improve the rates of live birth
20 Jan, 2023 | 14:45h | UTCEffect of Timing by Endometrial Receptivity Testing vs Standard Timing of Frozen Embryo Transfer on Live Birth in Patients Undergoing In Vitro Fertilization: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)
Commentary on Twitter
Study findings do not support routine use of receptivity testing to guide the timing of embryo transfer during in vitro fertilization. https://t.co/p8jqTpRAfV #Research
— JAMA (@JAMA_current) December 6, 2022
Cohort Study | Neurodevelopmental disorders in offspring conceived via IVF vs. intracytoplasmic sperm injection
19 Jan, 2023 | 14:12h | UTC
Review | Pathophysiology, diagnosis, and management of endometriosis.
16 Dec, 2022 | 13:23h | UTCPathophysiology, diagnosis, and management of endometriosis – The BMJ
Cohort Study | Obstetric and perinatal outcomes of singleton births following single- vs. double-embryo transfer.
6 Dec, 2022 | 13:45h | UTC
Commentary on Twitter
Swedish study comparing outcomes in singleton births following either single or double embryo transfer found higher risks of very preterm birth and low birth weight after double embryo transfer, especially when using frozen embryos and blastocysts. https://t.co/CXRXrchbw1
— JAMA Pediatrics (@JAMAPediatrics) December 5, 2022
Guideline Synopsis | Diagnosis and treatment of infertility in men.
23 Nov, 2022 | 14:08h | UTCDiagnosis and Treatment of Infertility in Men – JAMA (free for a limited period)
Original Guideline: AUA/ASRM Guideline: Diagnosis and treatment of infertility in men
SR | Follicular flushing during oocyte retrieval in assisted reproductive techniques.
23 Nov, 2022 | 13:46h | UTCFollicular flushing during oocyte retrieval in assisted reproductive techniques – Cochrane Library
Commentary on Twitter
Updated #review! We are uncertain of the effect of follicular flushing on live birth rate and miscarriage rate compared to aspiration alone @exgeorgiou @meloordep @CochraneLibraryhttps://t.co/VoORVrg8X4#infertility #IVF pic.twitter.com/qmZdHWAGDm
— Cochrane Gynaecology & Fertility (@CochraneCGF) November 21, 2022
Perspective | The case for mild stimulation for in vitro fertilization.
14 Oct, 2022 | 14:07h | UTC
Commentary on Twitter
New Review paper from @GeetaNargund & the #ISMAAR committee recommends mild ovarian stimulation for IVF should be considered in all clinical scenarios, for effective pregnancy outcomes
Safer, better tolerated and less expensive than conventional IVF.https://t.co/Jv2H2ucQUc pic.twitter.com/LtOSfE98PG
— RBMOnline (@RBMOnline) September 9, 2022
Systematic Review | Aromatase inhibitors (letrozole) for ovulation induction in infertile women with polycystic ovary syndrome.
30 Sep, 2022 | 12:29h | UTC
Commentary on Twitter
Hot off the press! #Letrozole for #ovulation induction improves live birth and #pregnancy rates in #infertile women with anovulatory #PCOS, compared to SERMs (clomiphene citrate)
Read the full #Cochrane #review @CochraneLibrary https://t.co/coJ4rzvswz#PCOSAwarenessMonth pic.twitter.com/80ZmRibG5p— Cochrane Gynaecology & Fertility (@CochraneCGF) September 28, 2022
European Crohn’s and Colitis Guidelines on sexuality, fertility, pregnancy, and lactation.
29 Sep, 2022 | 13:30h | UTC
Cohort Study | Children conceived via assisted reproductive technologies are at increased risk of childhood cancers.
7 Sep, 2022 | 12:32h | UTCAssisted Reproductive Technology and Risk of Childhood Cancers – JAMA Network Open
Invited Commentary: Fertility Treatment and Childhood Cancer Risk – JAMA Network Open
Commentary on Twitter
Children born of assisted reproductive technology (ART) conception was associated with an increased risk of overall childhood cancers compared with those conceived naturally and those with subfertility and non-ART conception. #OpenAccess #Research https://t.co/HylUVE4gFg
— JAMA Network Open (@JAMANetworkOpen) August 31, 2022
Cohort Study | Fertility preservation procedures appear to be safe at the time of breast cancer diagnosis.
7 Sep, 2022 | 12:31h | UTCNews Release: Fertility preservation measures do not appear to increase the risk of breast cancer recurrence – Karolinska Institutet
Systematic Review | Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse.
2 Sep, 2022 | 13:08h | UTC
Commentary on Twitter
❓ What is the effectiveness and safety of luteal support for those trying to conceive by intrauterine insemination #IUI or by sexual intercourse?
New @CochraneCGF systematic review looks at the evidence from 25 RCTs involving 5,111 participants. https://t.co/jjsetCMo3E pic.twitter.com/tWNtGx8rdC— The Cochrane Library (@CochraneLibrary) September 2, 2022
Cohort Study | Association of assisted reproductive technology with offspring growth and adiposity from infancy to early adulthood.
1 Aug, 2022 | 11:54h | UTC
Commentary on Twitter
This cohort study found that differences in early growth and adiposity for people conceived via assisted reproductive technology (vs. naturally) were small and reduced with older age. @aelhak19 @DeborahLawlor2 https://t.co/hwdldN6yDf
— JAMA Network Open (@JAMANetworkOpen) July 26, 2022
Report | The first 5 years of uterus transplant in the US.
13 Jul, 2022 | 11:27h | UTCThe First 5 Years of Uterus Transplant in the US: A Report From the United States Uterus Transplant Consortium – JAMA Surgery (link to abstract – $ for full-text)
Commentary: Good Outcomes From First 5 Years of Uterus Transplants, But Concerns Remain – U.S.News
Commentary on Twitter
A multi-center study found uterus transplantation in the United States to be a safe, effective therapy for women with uterine-factor infertility to have children. https://t.co/nNYgjdP0fA
— JAMA Surgery (@JAMASurgery) July 6, 2022
RCT | Intravenous immunoglobulin treatment in women with four or more recurrent pregnancy losses.
12 Jul, 2022 | 11:53h | UTC
Infertility, recurrent pregnancy loss, and risk of stroke: pooled analysis of individual patient data of 618 851 women.
27 Jun, 2022 | 11:59h | UTCNews Release: Infertility and pregnancy loss may increase women’s risk of stroke – BMJ Newsroom
Commentary on Twitter
Infertility and pregnancy loss are associated with an increased risk of non-fatal and fatal stroke in later life, finds study.
Early monitoring of women who have experienced miscarriage or stillbirth could lower the risk, the researchers suggest https://t.co/fYrNfpz6fC
— The BMJ (@bmj_latest) June 24, 2022
RCT: Transfer of thawed frozen embryo versus fresh embryo to improve the healthy baby rate in women undergoing IVF.
21 Jun, 2022 | 10:32h | UTCRelated: Fresh versus frozen embryo transfers in assisted reproduction – Cochrane Library