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Fertility/Reproductive Medicine

Cohort Study | Children conceived via assisted reproductive technologies are at increased risk of childhood cancers.

7 Sep, 2022 | 12:32h | UTC

Assisted Reproductive Technology and Risk of Childhood Cancers – JAMA Network Open

Invited Commentary: Fertility Treatment and Childhood Cancer Risk – JAMA Network Open

 

Commentary on Twitter

 


Cohort Study | Fertility preservation procedures appear to be safe at the time of breast cancer diagnosis.

7 Sep, 2022 | 12:31h | UTC

Relapse Rates and Disease-Specific Mortality Following Procedures for Fertility Preservation at Time of Breast Cancer Diagnosis – JAMA Oncology

News Release: Fertility preservation measures do not appear to increase the risk of breast cancer recurrence – Karolinska Institutet

Commentary: Fertility Preservation Measures Do Not Appear to Increase the Risk of Breast Cancer Recurrence – The ASCO Post

 


Systematic Review | Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse.

2 Sep, 2022 | 13:08h | UTC

Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse – Cochrane Library

 

Commentary on Twitter

 


Cohort Study | Association of assisted reproductive technology with offspring growth and adiposity from infancy to early adulthood.

1 Aug, 2022 | 11:54h | UTC

Association of Assisted Reproductive Technology With Offspring Growth and Adiposity From Infancy to Early Adulthood – JAMA Network Open

News Release: Concerns about effects of fertility treatment on children’s development are unwarranted, large study suggest – University of Bristol

 

Commentary on Twitter

 


Report | The first 5 years of uterus transplant in the US.

13 Jul, 2022 | 11:27h | UTC

The First 5 Years of Uterus Transplant in the US: A Report From the United States Uterus Transplant Consortium – JAMA Surgery (link to abstract – $ for full-text)

Commentary: Good Outcomes From First 5 Years of Uterus Transplants, But Concerns Remain – U.S.News

 

Commentary on Twitter

 


RCT | Intravenous immunoglobulin treatment in women with four or more recurrent pregnancy losses.

12 Jul, 2022 | 11:53h | UTC

Intravenous immunoglobulin treatment in women with four or more recurrent pregnancy losses: A double-blind, randomised, placebo-controlled trial – eClinicalMedicine

 


Infertility, recurrent pregnancy loss, and risk of stroke: pooled analysis of individual patient data of 618 851 women.

27 Jun, 2022 | 11:59h | UTC

Infertility, recurrent pregnancy loss, and risk of stroke: pooled analysis of individual patient data of 618 851 women – The BMJ

News Release: Infertility and pregnancy loss may increase women’s risk of stroke – BMJ Newsroom

 

Commentary on Twitter

 


RCT: Transfer of thawed frozen embryo versus fresh embryo to improve the healthy baby rate in women undergoing IVF.

21 Jun, 2022 | 10:32h | UTC

Transfer of thawed frozen embryo versus fresh embryo to improve the healthy baby rate in women undergoing IVF: the E-Freeze RCT – Health Technology Assessment

Related: Fresh versus frozen embryo transfers in assisted reproduction – Cochrane Library

 


[News release – not published yet] Women not being routinely informed that a common anesthetic may lessen contraception effectiveness, doctors warn.

9 Jun, 2022 | 11:31h | UTC

Women not being routinely informed that a common anesthetic may lessen contraception effectiveness, doctors warn – The European Society of Anaesthesiology and Intensive Care (ESAIC)

Commentary: Women in UK ‘seldom’ told drug used in surgery can impede contraception – The Guardian

 


RCT: Efficacy of bariatric surgery in treating women with obesity and polycystic ovary syndrome.

3 Jun, 2022 | 11:05h | UTC

Efficacy of Bariatric Surgery in the Treatment of Women With Obesity and Polycystic Ovary Syndrome – The Journal of Clinical Endocrinology & Metabolism

 


Systematic Review: Cleavage‐stage versus blastocyst‐stage embryo transfer in assisted reproductive technology.

1 Jun, 2022 | 11:02h | UTC

Cleavage‐stage versus blastocyst‐stage embryo transfer in assisted reproductive technology – Cochrane Library

Summary: When trying to have a baby through assisted conception, is it better to transfer the embryo to the womb on day 3 or day 5? – Cochrane Library

 

Commentary on Twitter

 


Cohort Study: Analysis of antiemetic use after initiation of hormone therapy.

27 May, 2022 | 11:21h | UTC

Analysis of Antiemetic Use After Initiation of Hormone Therapy – JAMA Network Open

 


M-A: Effectiveness and harms of contraceptive counseling and provision interventions for women.

26 May, 2022 | 10:23h | UTC

Effectiveness and Harms of Contraceptive Counseling and Provision Interventions for Women: A Systematic Review and Meta-analysis – Annals of Internal Medicine (link to abstract – $ for full-text)

Annals Video Summary: Effectiveness and Harms of Contraceptive Counseling and Provision Interventions for Women: A Systematic Review and Meta-analysis

Commentary: Contraceptive counseling, provision increases use, reduces unintended pregnancy – ACP Internist

 


Endometrial scratch to increase live birth rates in women undergoing first-time in vitro fertilization: RCT and systematic review.

12 May, 2022 | 07:53h | UTC

Endometrial scratch to increase live birth rates in women undergoing first-time in vitro fertilisation: RCT and systematic review – Health Technology Assessment

Related:

Survey: Despite insufficient evidence of benefit, many fertility specialists still perform endometrial scratching before in vitro fertilization.

Endometrial scratching: what’s the latest evidence? – “we are uncertain whether endometrial injury has an effect on the probability of getting pregnant and having a baby”.

A Randomized Trial of Endometrial Scratching before In Vitro Fertilization – New England Journal of Medicine

 


Obesity and risk of female reproductive conditions: A Mendelian randomization study.

27 Apr, 2022 | 01:31h | UTC

Obesity and risk of female reproductive conditions: A Mendelian randomisation study – PLOS Medicine

News Release: Obesity may increase risk of some female reproductive disorders – PLOS

 


Cohort Study: Infertility in women linked to increased risk of heart failure with preserved ejection fraction.

20 Apr, 2022 | 09:44h | UTC

Infertility and Risk of Heart Failure in the Women’s Health Initiative – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Podcast: Infertility and Risk of Heart Failure in the Women’s Health Initiative

Commentaries:

Infertility in Women Linked to Subsequent Risk of HFpEF – TCTMD

MGH study finds infertility associated with increased risk of heart failure – MedicalResearch

 


M-A: Risk of recurrence in women with venous thromboembolism related to estrogen-containing contraceptives.

6 Apr, 2022 | 10:55h | UTC

Risk of recurrence in women with venous thromboembolism related to estrogen-containing contraceptives: Systematic review and meta-analysis – Journal of Thrombosis and Haemostasis

 


IVF add-ons: why you should be cautious of these expensive procedures if you’re trying to conceive.

1 Apr, 2022 | 08:44h | UTC

IVF add-ons: why you should be cautious of these expensive procedures if you’re trying to conceive – The Conversation

Related:

Survey: Despite insufficient evidence of benefit, many fertility specialists still perform endometrial scratching before in vitro fertilization.

Endometrial scratching: what’s the latest evidence? – “we are uncertain whether endometrial injury has an effect on the probability of getting pregnant and having a baby”.

A Randomized Trial of Endometrial Scratching before In Vitro Fertilization – New England Journal of Medicine

Study shows whole-genome risk prediction of common diseases in human preimplantation embryos is feasible, leading to ethical concerns.

Randomized Trial: Conventional in vitro fertilization resulted in a cumulative live-birth rate that was noninferior to live-birth rates with the addition of preimplantation genetic testing for aneuploidy.

RCT: Intracytoplasmic sperm injection vs. conventional in-vitro fertilization in couples with infertility in whom the male partner has normal total sperm count and motility – no difference in livebirth rates between the strategies

Randomized Trial: Acupuncture Not Effective for Improving the Likelihood of In Vitro Fertilization

Research: Transfer of Fresh versus Frozen Embryos in Ovulatory Women

Randomized trial: Freeze-all vs. fresh blastocyst transfer strategy during in vitro fertilization in women with regular menstrual cycles

 


Guidance on the need for contraception related to use of pharmaceuticals: providing information on the proper use of pharmaceuticals in patients with reproductive potential.

31 Mar, 2022 | 07:49h | UTC

Guidance on the need for contraception related to use of pharmaceuticals: the Japan Agency for Medical Research and Development Study Group for providing information on the proper use of pharmaceuticals in patients with reproductive potential

 


Cohort Study: Preconception paternal use of metformin linked to increased risk of congenital problems in offspring.

29 Mar, 2022 | 10:04h | UTC

Preconception Antidiabetic Drugs in Men and Birth Defects in Offspring: A Nationwide Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries:

Paternal metformin use associated with major birth defects if used during period of sperm development – American College of Physicians

Expert reaction to study of birth defects and diabetic men using metformin during sperm development – Science Media Centre

 


Study shows whole-genome risk prediction of common diseases in human preimplantation embryos is feasible, leading to ethical concerns.

22 Mar, 2022 | 09:42h | UTC

Whole-genome risk prediction of common diseases in human preimplantation embryos – Nature Medicine

Invited Commentaries:

Polygenic embryo testing: understated ethics, unclear utility – Nature Medicine

The uncertain science of preimplantation and prenatal genetic testing – Nature Medicine

Commentary: As genetic testing of human embryos expand, researchers call for frank assessment of profound ethical implications – The Hastings Center

Related: Opinion | “The use of polygenic risk scores in pre-implantation genetic testing: an unproven, unethical practice”.

 

Commentary on Twitter (thread – click for more)

 


RCT: A preconception lifestyle intervention for weight loss did not improve fertility rates among women with obesity and infertility.

15 Mar, 2022 | 08:34h | UTC

Effects of preconception lifestyle intervention in infertile women with obesity: The FIT-PLESE randomized controlled trial – PLOS Medicine

Commentary: Weight loss doesn’t help pregnancy chances, study finds – University of Virginia Health System

 


Choosing Wisely Canada: Canadian fertility and andrology society’s list of top items physicians and patients should question in fertility medicine.

14 Mar, 2022 | 01:23h | UTC

Choosing Wisely Canada: Canadian fertility and andrology society’s list of top items physicians and patients should question in fertility medicine – Archives of Gynecology and Obstetrics (if the link is paywalled, try this one)

See complete lists of low-value practices: Choosing Wisely U.S. / Choosing Wisely UK / Choosing Wisely Australia AND Choosing Wisely Canada

 


Bioethics | The rupture of anonymity for sperm donors—a tangled web of conflicting rights.

14 Mar, 2022 | 00:49h | UTC

The rupture of anonymity for sperm donors—a tangled web of conflicting rights – The BMJ

 

Commentary on Twitter

 


Survey: Despite insufficient evidence of benefit, many fertility specialists still perform endometrial scratching before in vitro fertilization.

9 Feb, 2022 | 08:19h | UTC

Endometrial scratching in Australia, New Zealand and the United Kingdom (UK): a follow-up survey – Human Fertility

Commentary: Too Many Fertility Specialists Still Use a Painful, Useless Procedure: Study – HealthDay

Related:

Endometrial scratching: what’s the latest evidence? – “we are uncertain whether endometrial injury has an effect on the probability of getting pregnant and having a baby”.

A Randomized Trial of Endometrial Scratching before In Vitro Fertilization – New England Journal of Medicine

 


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