Fertility/Reproductive Medicine
RCT: Transfer of thawed frozen embryo versus fresh embryo to improve the healthy baby rate in women undergoing IVF.
21 Jun, 2022 | 10:32h | UTCRelated: Fresh versus frozen embryo transfers in assisted reproduction – Cochrane Library
[News release – not published yet] Women not being routinely informed that a common anesthetic may lessen contraception effectiveness, doctors warn.
9 Jun, 2022 | 11:31h | UTCCommentary: Women in UK ‘seldom’ told drug used in surgery can impede contraception – The Guardian
RCT: Efficacy of bariatric surgery in treating women with obesity and polycystic ovary syndrome.
3 Jun, 2022 | 11:05h | UTC
Systematic Review: Cleavage‐stage versus blastocyst‐stage embryo transfer in assisted reproductive technology.
1 Jun, 2022 | 11:02h | UTC
Commentary on Twitter
Transferring fresh embryos at the blastocyst stage (day 5 to 6) may increase live births compared to transfer at cleavage stage (day 2 to 3). We are uncertain if blastocyst‐stage transfer increases multiple pregnancy or miscarriage @CochraneLibrary https://t.co/O5CrUPTpet pic.twitter.com/YNdrwCIkmt
— Cochrane Gynaecology & Fertility (@CochraneCGF) May 25, 2022
Cohort Study: Analysis of antiemetic use after initiation of hormone therapy.
27 May, 2022 | 11:21h | UTCAnalysis of Antiemetic Use After Initiation of Hormone Therapy – JAMA Network Open
M-A: Effectiveness and harms of contraceptive counseling and provision interventions for women.
26 May, 2022 | 10:23h | UTCEffectiveness and Harms of Contraceptive Counseling and Provision Interventions for Women: A Systematic Review and Meta-analysis – Annals of Internal Medicine (link to abstract – $ for full-text)
Annals Video Summary: Effectiveness and Harms of Contraceptive Counseling and Provision Interventions for Women: A Systematic Review and Meta-analysis
Commentary: Contraceptive counseling, provision increases use, reduces unintended pregnancy – ACP Internist
Endometrial scratch to increase live birth rates in women undergoing first-time in vitro fertilization: RCT and systematic review.
12 May, 2022 | 07:53h | UTCRelated:
Obesity and risk of female reproductive conditions: A Mendelian randomization study.
27 Apr, 2022 | 01:31h | UTCObesity and risk of female reproductive conditions: A Mendelian randomisation study – PLOS Medicine
News Release: Obesity may increase risk of some female reproductive disorders – PLOS
Cohort Study: Infertility in women linked to increased risk of heart failure with preserved ejection fraction.
20 Apr, 2022 | 09:44h | UTCInfertility and Risk of Heart Failure in the Women’s Health Initiative – Journal of the American College of Cardiology (link to abstract – $ for full-text)
Podcast: Infertility and Risk of Heart Failure in the Women’s Health Initiative
Commentaries:
Infertility in Women Linked to Subsequent Risk of HFpEF – TCTMD
MGH study finds infertility associated with increased risk of heart failure – MedicalResearch
M-A: Risk of recurrence in women with venous thromboembolism related to estrogen-containing contraceptives.
6 Apr, 2022 | 10:55h | UTC
IVF add-ons: why you should be cautious of these expensive procedures if you’re trying to conceive.
1 Apr, 2022 | 08:44h | UTCRelated:
Randomized Trial: Acupuncture Not Effective for Improving the Likelihood of In Vitro Fertilization
Research: Transfer of Fresh versus Frozen Embryos in Ovulatory Women
Guidance on the need for contraception related to use of pharmaceuticals: providing information on the proper use of pharmaceuticals in patients with reproductive potential.
31 Mar, 2022 | 07:49h | UTC
Cohort Study: Preconception paternal use of metformin linked to increased risk of congenital problems in offspring.
29 Mar, 2022 | 10:04h | UTCPreconception Antidiabetic Drugs in Men and Birth Defects in Offspring: A Nationwide Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries:
Study shows whole-genome risk prediction of common diseases in human preimplantation embryos is feasible, leading to ethical concerns.
22 Mar, 2022 | 09:42h | UTCWhole-genome risk prediction of common diseases in human preimplantation embryos – Nature Medicine
Invited Commentaries:
Polygenic embryo testing: understated ethics, unclear utility – Nature Medicine
The uncertain science of preimplantation and prenatal genetic testing – Nature Medicine
Commentary on Twitter (thread – click for more)
Preimplantation genetic testing of human embryos is a rapidly advancing field, but scientists and ethicists are calling for caution.
We present 3 articles highlighting new research and expert commentary on this controversial topic.
THREAD 🧵— Nature Medicine (@NatureMedicine) March 21, 2022
RCT: A preconception lifestyle intervention for weight loss did not improve fertility rates among women with obesity and infertility.
15 Mar, 2022 | 08:34h | UTCCommentary: Weight loss doesn’t help pregnancy chances, study finds – University of Virginia Health System
Choosing Wisely Canada: Canadian fertility and andrology society’s list of top items physicians and patients should question in fertility medicine.
14 Mar, 2022 | 01:23h | UTCChoosing Wisely Canada: Canadian fertility and andrology society’s list of top items physicians and patients should question in fertility medicine – Archives of Gynecology and Obstetrics (if the link is paywalled, try this one)
See complete lists of low-value practices: Choosing Wisely U.S. / Choosing Wisely UK / Choosing Wisely Australia AND Choosing Wisely Canada
Bioethics | The rupture of anonymity for sperm donors—a tangled web of conflicting rights.
14 Mar, 2022 | 00:49h | UTCThe rupture of anonymity for sperm donors—a tangled web of conflicting rights – The BMJ
Commentary on Twitter
Direct-to-consumer DNA testing has torn the veil separating social family and genetic heritage. This Opinion article examines how it has brought the rights of donor conceived people to information into conflict with donors’ right to privacyhttps://t.co/avX64dbnhb
— The BMJ (@bmj_latest) March 11, 2022
Survey: Despite insufficient evidence of benefit, many fertility specialists still perform endometrial scratching before in vitro fertilization.
9 Feb, 2022 | 08:19h | UTCCommentary: Too Many Fertility Specialists Still Use a Painful, Useless Procedure: Study – HealthDay
Related:
Opinion | “The use of polygenic risk scores in pre-implantation genetic testing: an unproven, unethical practice”.
26 Jan, 2022 | 01:52h | UTCCommentary: ‘Unproven and unethical’: experts warn against genetic embryo tests – The Guardian
Randomized Trial: Conventional in vitro fertilization resulted in a cumulative live-birth rate that was noninferior to live-birth rates with the addition of preimplantation genetic testing for aneuploidy.
28 Nov, 2021 | 21:14h | UTCLive Birth with or without Preimplantation Genetic Testing for Aneuploidy – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: New research casts fresh doubt on a common procedure that promises to increase the odds of IVF – STAT
Systematic Review: Agents for ovarian stimulation for intrauterine insemination (IUI) in ovulatory women with infertility.
11 Nov, 2021 | 08:23h | UTCOriginal Study: Agents for ovarian stimulation for intrauterine insemination (IUI) in ovulatory women with infertility – Cochrane Library
COVID vaccines show no signs of harming fertility or sexual function.
26 Aug, 2021 | 09:12h | UTCCOVID Vaccines Show No Signs of Harming Fertility or Sexual Function – Scientific American
Related: Study: Sperm parameters not changed before and after COVID-19 mRNA vaccination.
Endometrial scratching: what’s the latest evidence? – “we are uncertain whether endometrial injury has an effect on the probability of getting pregnant and having a baby”.
8 Aug, 2021 | 23:33h | UTCEndometrial scratching: what’s the latest evidence? – Cochrane Library
Original Review: Endometrial injury for pregnancy following sexual intercourse or intrauterine insemination – Cochrane Library
Commentary on Twitter
Endometrial scratching is a procedure that is sometimes done with the aim of increasing the chance of pregnancy, but its use is debated. @SarahLensen of @CochraenCGF explains the latest Cochrane evidence in this new @CochraneUK blog: https://t.co/IFyYlXvS6v pic.twitter.com/PDEWRx4JPA
— Cochrane (@cochranecollab) August 6, 2021
Review: Diagnosis and Management of Infertility.
12 Jul, 2021 | 01:34h | UTCDiagnosis and Management of Infertility: A Review – JAMA (free for a limited period)
Commentary on Twitter
Although success rates vary by age and diagnosis, accurate diagnosis and effective therapy along with shared decision-making can facilitate achievement of fertility goals in many couples treated for #infertility https://t.co/7nR0nuFC3K
— JAMA (@JAMA_current) July 9, 2021
The Lancet Series | Miscarriage matters
3 May, 2021 | 05:11h | UTCEditorial: Miscarriage: worldwide reform of care is needed
- Miscarriage matters: the epidemiological, physical, psychological, and economic costs of early pregnancy loss
- Sporadic miscarriage: evidence to provide effective care
- Recurrent miscarriage: evidence to accelerate action