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Fertility/Reproductive Medicine

RCT: Transfer of thawed frozen embryo versus fresh embryo to improve the healthy baby rate in women undergoing IVF.

21 Jun, 2022 | 10:32h | UTC

Transfer of thawed frozen embryo versus fresh embryo to improve the healthy baby rate in women undergoing IVF: the E-Freeze RCT – Health Technology Assessment

Related: Fresh versus frozen embryo transfers in assisted reproduction – Cochrane Library

 


[News release – not published yet] Women not being routinely informed that a common anesthetic may lessen contraception effectiveness, doctors warn.

9 Jun, 2022 | 11:31h | UTC

Women not being routinely informed that a common anesthetic may lessen contraception effectiveness, doctors warn – The European Society of Anaesthesiology and Intensive Care (ESAIC)

Commentary: Women in UK ‘seldom’ told drug used in surgery can impede contraception – The Guardian

 


RCT: Efficacy of bariatric surgery in treating women with obesity and polycystic ovary syndrome.

3 Jun, 2022 | 11:05h | UTC

Efficacy of Bariatric Surgery in the Treatment of Women With Obesity and Polycystic Ovary Syndrome – The Journal of Clinical Endocrinology & Metabolism

 


Systematic Review: Cleavage‐stage versus blastocyst‐stage embryo transfer in assisted reproductive technology.

1 Jun, 2022 | 11:02h | UTC

Cleavage‐stage versus blastocyst‐stage embryo transfer in assisted reproductive technology – Cochrane Library

Summary: When trying to have a baby through assisted conception, is it better to transfer the embryo to the womb on day 3 or day 5? – Cochrane Library

 

Commentary on Twitter

 


Cohort Study: Analysis of antiemetic use after initiation of hormone therapy.

27 May, 2022 | 11:21h | UTC

Analysis of Antiemetic Use After Initiation of Hormone Therapy – JAMA Network Open

 


M-A: Effectiveness and harms of contraceptive counseling and provision interventions for women.

26 May, 2022 | 10:23h | UTC

Effectiveness and Harms of Contraceptive Counseling and Provision Interventions for Women: A Systematic Review and Meta-analysis – Annals of Internal Medicine (link to abstract – $ for full-text)

Annals Video Summary: Effectiveness and Harms of Contraceptive Counseling and Provision Interventions for Women: A Systematic Review and Meta-analysis

Commentary: Contraceptive counseling, provision increases use, reduces unintended pregnancy – ACP Internist

 


Endometrial scratch to increase live birth rates in women undergoing first-time in vitro fertilization: RCT and systematic review.

12 May, 2022 | 07:53h | UTC

Endometrial scratch to increase live birth rates in women undergoing first-time in vitro fertilisation: RCT and systematic review – Health Technology Assessment

Related:

Survey: Despite insufficient evidence of benefit, many fertility specialists still perform endometrial scratching before in vitro fertilization.

Endometrial scratching: what’s the latest evidence? – “we are uncertain whether endometrial injury has an effect on the probability of getting pregnant and having a baby”.

A Randomized Trial of Endometrial Scratching before In Vitro Fertilization – New England Journal of Medicine

 


Obesity and risk of female reproductive conditions: A Mendelian randomization study.

27 Apr, 2022 | 01:31h | UTC

Obesity and risk of female reproductive conditions: A Mendelian randomisation study – PLOS Medicine

News Release: Obesity may increase risk of some female reproductive disorders – PLOS

 


Cohort Study: Infertility in women linked to increased risk of heart failure with preserved ejection fraction.

20 Apr, 2022 | 09:44h | UTC

Infertility and Risk of Heart Failure in the Women’s Health Initiative – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Podcast: Infertility and Risk of Heart Failure in the Women’s Health Initiative

Commentaries:

Infertility in Women Linked to Subsequent Risk of HFpEF – TCTMD

MGH study finds infertility associated with increased risk of heart failure – MedicalResearch

 


M-A: Risk of recurrence in women with venous thromboembolism related to estrogen-containing contraceptives.

6 Apr, 2022 | 10:55h | UTC

Risk of recurrence in women with venous thromboembolism related to estrogen-containing contraceptives: Systematic review and meta-analysis – Journal of Thrombosis and Haemostasis

 


IVF add-ons: why you should be cautious of these expensive procedures if you’re trying to conceive.

1 Apr, 2022 | 08:44h | UTC

IVF add-ons: why you should be cautious of these expensive procedures if you’re trying to conceive – The Conversation

Related:

Survey: Despite insufficient evidence of benefit, many fertility specialists still perform endometrial scratching before in vitro fertilization.

Endometrial scratching: what’s the latest evidence? – “we are uncertain whether endometrial injury has an effect on the probability of getting pregnant and having a baby”.

A Randomized Trial of Endometrial Scratching before In Vitro Fertilization – New England Journal of Medicine

Study shows whole-genome risk prediction of common diseases in human preimplantation embryos is feasible, leading to ethical concerns.

Randomized Trial: Conventional in vitro fertilization resulted in a cumulative live-birth rate that was noninferior to live-birth rates with the addition of preimplantation genetic testing for aneuploidy.

RCT: Intracytoplasmic sperm injection vs. conventional in-vitro fertilization in couples with infertility in whom the male partner has normal total sperm count and motility – no difference in livebirth rates between the strategies

Randomized Trial: Acupuncture Not Effective for Improving the Likelihood of In Vitro Fertilization

Research: Transfer of Fresh versus Frozen Embryos in Ovulatory Women

Randomized trial: Freeze-all vs. fresh blastocyst transfer strategy during in vitro fertilization in women with regular menstrual cycles

 


Guidance on the need for contraception related to use of pharmaceuticals: providing information on the proper use of pharmaceuticals in patients with reproductive potential.

31 Mar, 2022 | 07:49h | UTC

Guidance on the need for contraception related to use of pharmaceuticals: the Japan Agency for Medical Research and Development Study Group for providing information on the proper use of pharmaceuticals in patients with reproductive potential

 


Cohort Study: Preconception paternal use of metformin linked to increased risk of congenital problems in offspring.

29 Mar, 2022 | 10:04h | UTC

Preconception Antidiabetic Drugs in Men and Birth Defects in Offspring: A Nationwide Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries:

Paternal metformin use associated with major birth defects if used during period of sperm development – American College of Physicians

Expert reaction to study of birth defects and diabetic men using metformin during sperm development – Science Media Centre

 


Study shows whole-genome risk prediction of common diseases in human preimplantation embryos is feasible, leading to ethical concerns.

22 Mar, 2022 | 09:42h | UTC

Whole-genome risk prediction of common diseases in human preimplantation embryos – Nature Medicine

Invited Commentaries:

Polygenic embryo testing: understated ethics, unclear utility – Nature Medicine

The uncertain science of preimplantation and prenatal genetic testing – Nature Medicine

Commentary: As genetic testing of human embryos expand, researchers call for frank assessment of profound ethical implications – The Hastings Center

Related: Opinion | “The use of polygenic risk scores in pre-implantation genetic testing: an unproven, unethical practice”.

 

Commentary on Twitter (thread – click for more)

 


RCT: A preconception lifestyle intervention for weight loss did not improve fertility rates among women with obesity and infertility.

15 Mar, 2022 | 08:34h | UTC

Effects of preconception lifestyle intervention in infertile women with obesity: The FIT-PLESE randomized controlled trial – PLOS Medicine

Commentary: Weight loss doesn’t help pregnancy chances, study finds – University of Virginia Health System

 


Choosing Wisely Canada: Canadian fertility and andrology society’s list of top items physicians and patients should question in fertility medicine.

14 Mar, 2022 | 01:23h | UTC

Choosing Wisely Canada: Canadian fertility and andrology society’s list of top items physicians and patients should question in fertility medicine – Archives of Gynecology and Obstetrics (if the link is paywalled, try this one)

See complete lists of low-value practices: Choosing Wisely U.S. / Choosing Wisely UK / Choosing Wisely Australia AND Choosing Wisely Canada

 


Bioethics | The rupture of anonymity for sperm donors—a tangled web of conflicting rights.

14 Mar, 2022 | 00:49h | UTC

The rupture of anonymity for sperm donors—a tangled web of conflicting rights – The BMJ

 

Commentary on Twitter

 


Survey: Despite insufficient evidence of benefit, many fertility specialists still perform endometrial scratching before in vitro fertilization.

9 Feb, 2022 | 08:19h | UTC

Endometrial scratching in Australia, New Zealand and the United Kingdom (UK): a follow-up survey – Human Fertility

Commentary: Too Many Fertility Specialists Still Use a Painful, Useless Procedure: Study – HealthDay

Related:

Endometrial scratching: what’s the latest evidence? – “we are uncertain whether endometrial injury has an effect on the probability of getting pregnant and having a baby”.

A Randomized Trial of Endometrial Scratching before In Vitro Fertilization – New England Journal of Medicine

 


Opinion | “The use of polygenic risk scores in pre-implantation genetic testing: an unproven, unethical practice”.

26 Jan, 2022 | 01:52h | UTC

The use of polygenic risk scores in pre-implantation genetic testing: an unproven, unethical practice – European Journal of Human Genetics

Commentary: ‘Unproven and unethical’: experts warn against genetic embryo tests – The Guardian

 


Randomized Trial: Conventional in vitro fertilization resulted in a cumulative live-birth rate that was noninferior to live-birth rates with the addition of preimplantation genetic testing for aneuploidy.

28 Nov, 2021 | 21:14h | UTC

Live Birth with or without Preimplantation Genetic Testing for Aneuploidy – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: New research casts fresh doubt on a common procedure that promises to increase the odds of IVF – STAT

 


Systematic Review: Agents for ovarian stimulation for intrauterine insemination (IUI) in ovulatory women with infertility.

11 Nov, 2021 | 08:23h | UTC

Summary: Which medicines are most effective for women trying to get pregnant by ‘intrauterine insemination’ (where sperm is placed directly in the womb)? – Cochrane Library

Original Study: Agents for ovarian stimulation for intrauterine insemination (IUI) in ovulatory women with infertility – Cochrane Library

 


COVID vaccines show no signs of harming fertility or sexual function.

26 Aug, 2021 | 09:12h | UTC

COVID Vaccines Show No Signs of Harming Fertility or Sexual Function – Scientific American

Related: Study: Sperm parameters not changed before and after COVID-19 mRNA vaccination.

 


Endometrial scratching: what’s the latest evidence? – “we are uncertain whether endometrial injury has an effect on the probability of getting pregnant and having a baby”.

8 Aug, 2021 | 23:33h | UTC

Endometrial scratching: what’s the latest evidence? – Cochrane Library

Original Review: Endometrial injury for pregnancy following sexual intercourse or intrauterine insemination – Cochrane Library

 

Commentary on Twitter

 


Review: Diagnosis and Management of Infertility.

12 Jul, 2021 | 01:34h | UTC

Diagnosis and Management of Infertility: A Review – JAMA (free for a limited period)

 

Commentary on Twitter

 


The Lancet Series | Miscarriage matters

3 May, 2021 | 05:11h | UTC

Editorial: Miscarriage: worldwide reform of care is needed

 


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