Internal Medicine
ISTH Interim Guidance for the Diagnosis and Treatment on Vaccine Induced Immune Thrombotic Thrombocytopenia
21 Apr, 2021 | 07:11h | UTCSee also: Diagnostic Flow Chart
Commentary on Twitter
The ISTH has released interim guidance on vaccine-induced immune thrombotic thrombocytopenia (#VITT) to inform the management of suspected thrombosis in subjects who have recently received the AstraZeneca or Johnson & Johnson vaccine. https://t.co/qqtQtpywaf pic.twitter.com/wNmjNNDs4z
— ISTH (@isth) April 20, 2021
Vaccine-induced Immune Thrombotic Thrombocytopenia: Frequently Asked Questions
21 Apr, 2021 | 07:09h | UTC
COVID-19 Vaccine Janssen: EMA finds possible link to very rare cases of unusual blood clots with low blood platelets
21 Apr, 2021 | 07:07h | UTCCommentary: Johnson & Johnson vaccine: EU regulator says blood clot very rare side effect – BBC
Commentary on Twitter
EMA has concluded there is a possible link between TTS (thrombosis & thrombocytopenia syndrome) & the J&J vaccine, & they will be adding it as a rare side effect to the product information: the same as for AZ, but so far reported at a much lower rate…1/n https://t.co/aonOEObeHR
— Hilda Bastian, PhD (@hildabast) April 20, 2021
We know a lot about Covid-19. Experts have many more questions
21 Apr, 2021 | 07:02h | UTCWe know a lot about Covid-19. Experts have many more questions – STAT
USPSTF Draft Statement: Insufficient evidence to recommend screening for atrial fibrillation
21 Apr, 2021 | 06:42h | UTCCommentary: Little evidence supports AFib screening in stroke prevention, group says – UPI
Cohort study: Increased bleeding risk with no therapeutic benefit with the addition of aspirin to direct oral anticoagulant therapy when there is not a clear indication
21 Apr, 2021 | 06:34h | UTCAdverse Events Associated With the Addition of Aspirin to Direct Oral Anticoagulant Therapy Without a Clear Indication – JAMA Internal Medicine (free for a limited period)
Commentaries: DOAC + Aspirin Common Without Clear Indication, Tied to More Bleeding – NEJM Journal Watch AND Many AFib patients wrongly prescribed aspirin therapy, study finds – UPI
Commentary on Twitter
Obs study in @JAMAInternalMed finds aspirin is often prescribed along w/ direct acting oral anticoagulant without clear reason and the combo *associates* w higher rates of bleeding https://t.co/nKsWtLnjr9
Good one @GBarnesMD
ASA is the number 1 drug I #deprescribe
— John Mandrola, MD (@drjohnm) April 19, 2021
Systematic review: Thrombolytic therapy for acute massive or submassive pulmonary embolism
21 Apr, 2021 | 06:20h | UTCThrombolytic therapy for pulmonary embolism – Cochrane Library
Summary: Drugs to dissolve pulmonary embolism (blood clot in the lungs) – Cochrane Library
Review: Perioperative Management of the Patient With Obstructive Sleep Apnea
21 Apr, 2021 | 06:18h | UTC
M-A: Portal venous system thrombosis after bariatric surgery
21 Apr, 2021 | 06:16h | UTCPortal venous system thrombosis after bariatric surgery: A systematic review and meta-analysis – Surgery (link to abstract – $ for full-text)
Chlamydia and gonorrhea: new recommendation to screen sexually active patients under 30
20 Apr, 2021 | 05:42h | UTCRelated USPSTF Draft Statement: Screening for Chlamydia and Gonorrhea – U.S. Preventive Services Task Force
Perspective | The Confident Generalist: Putting The Primary Care Physician Back At The Center
20 Apr, 2021 | 05:35h | UTCThe Confident Generalist: Putting The Primary Care Physician Back At The Center – Health Affairs
Podcast: Management of Obesity Hypoventilation Syndrome
20 Apr, 2021 | 05:23h | UTC#269 Obesity Hypoventilation Syndrome (OHS) and the Didgeridoo with Dr Aneesa Das – The Curbsiders
Podcast: Dementia Made Simple
20 Apr, 2021 | 05:21h | UTC#268 Dementia Made Simple with Dr. Josh Uy – The Curbsiders
Outcome of acute kidney injury: how to make a difference?
20 Apr, 2021 | 05:26h | UTCOutcome of acute kidney injury: how to make a difference? – Annals of Intensive Care
M-A: Diagnostic performance of different sampling approaches for SARS-CoV-2 RT-PCR testing
20 Apr, 2021 | 06:09h | UTCCommentary: Beyond COVID-19—will self-sampling and testing become the norm? – The Lancet Infectious Diseases
Related Meta-analysis: Saliva and nasopharyngeal swab nucleic acid amplification have similar diagnostic accuracy for the detection of SARS-CoV-2 AND Saliva vs. nasopharyngeal swabs equally sensitive for Covid-19 diagnosis
[News release – not published yet] Sputnik V demonstrates 97.6% efficacy according to the analysis of data of 3.8 million vaccinated persons in Russia
20 Apr, 2021 | 06:08h | UTC
Commentary on Twitter
Press release from Russia on Sputnik V claiming effectiveness is 97.6% based on a comparison of the infection rate of people fully vaxed & those with confirmed Covid-19; says a publication in the works, but no mention of safety data…1/n https://t.co/7V5cbUxTSV
— Hilda Bastian, PhD (@hildabast) April 19, 2021
COVID-19 dynamics after a national immunization program in Israel
20 Apr, 2021 | 06:06h | UTCCOVID-19 dynamics after a national immunization program in Israel – Nature Medicine
Commentary on Twitter
Our paper on the effect of Israel's vaccination program now out @NatureMedicine https://t.co/ENpKjz21uu
Life is now back to normal except for masks in closed places
Vaccines pretty much eradicated COVID-19 from Israel, at least for the time being
— Eran Segal (@segal_eran) April 19, 2021
M-A: Prevalence of depression, anxiety and post-traumatic stress disorder in health care workers during the COVID-19 pandemic
20 Apr, 2021 | 06:00h | UTC
Ten scientific reasons in support of airborne transmission of SARS-CoV-2
18 Apr, 2021 | 21:51h | UTCTen scientific reasons in support of airborne transmission of SARS-CoV-2 – The Lancet
Animated Videos: Aerosols and making spaces safe – University of Oxford
Commentary on Twitter (thread – click for more)
Just out in @TheLancet what experts have said for a year
SARS-CoV2 spreads PRIMARILY via airborne route
Failure to act on this has hampered efforts to prevent spread of COVID
Thank you @trishgreenhalgh @linseymarr @kprather88 @j_g_allen, others who stuck to the evidence https://t.co/uuJcUIKWHE
— Ashish K. Jha, MD, MPH (@ashishkjha) April 16, 2021
2021 Canadian Cardiovascular Society Guidelines for the Management of Dyslipidemia for the Prevention of Cardiovascular Disease in the Adult
18 Apr, 2021 | 21:24h | UTC
Commentary on Twitter
Check out the latest @SCC_CCS Guideline for the Management of Dyslipidemia for the Prevention of #Cardiovascular Disease!! https://t.co/ZKC7DrMIOq #HotOffThePress @ThanassoulisMD @ArdenBarry @DrNatDayan @RuthMcPherson12 @HeartDocRx @SCC_CCS_KT @SCC_CCS_CEO @SCC_CCS_Trainee pic.twitter.com/LZFbXNjztP
— CJC (@CJC_JCC) March 27, 2021
ESC Consensus Document: Personalized exercise prescription in the prevention and treatment of arterial hypertension
18 Apr, 2021 | 21:22h | UTCNews release: How to prevent and treat high blood pressure with exercise – European Society of Cardiology
RCT: Ravidasvir plus sofosbuvir are effective and well tolerated in patients with chronic HCV infection, with potential as an affordable treatment for these patients
18 Apr, 2021 | 21:19h | UTC
Commentary on Twitter
Trial results of new affordable #hepatitisC treatment showing 97% cure rate now published in @LancetGastroHep!
Ravidasvir + sofosbuvir has the potential to provide an additional affordable, simple, and efficacious #publichealth tool to eliminate HCV.
➡️https://t.co/Oo1ZHQnyn6 pic.twitter.com/FcFntfYMSC
— Drugs for Neglected Diseases initiative (@DNDi) April 16, 2021
Viewpoint | Implementing Measurement Science for Electronic Health Record Use – “Clinicians trained in patient care are locked into hours of screen time to complete mandatory clerical and documentation tasks, often unrelated to the quality of the care”
18 Apr, 2021 | 21:09h | UTCImplementing Measurement Science for Electronic Health Record Use – JAMA (free for a limited period)
Related: Opinion – “The EMR has changed the doctor-patient duet into a ménage-à-trois” (resources on the subject) AND Study: Association Between Perceived Electronic Health Record Usability and Professional Burnout (study and commentaries) AND The future of electronic health records – Nature
Commentaries on Twitter
To optimize #EHR design, implementation, and regulation, EHR use measures must be developed that are trustworthy, clinically important, scientifically sound, transparent, and feasible for implementation.
A recent paper by @JAMA_current @JAMANetwork https://t.co/IN3ZxcON9m pic.twitter.com/kOVQGI1OGl
— Eugenio Santoro (@eugeniosantoro) April 11, 2021
"Drawing attention to the EHR user experience with empirical measurements could add visibility and transparency to what is happening—the hours wasted and the risks incurred—that could stimulate usability improvements." https://t.co/WCzuo288Bp
— Janos Kalman (@kalman_jl) April 9, 2021
Indoor Air Changes and Potential Implications for SARS-CoV-2 Transmission
18 Apr, 2021 | 21:49h | UTCIndoor Air Changes and Potential Implications for SARS-CoV-2 Transmission – JAMA
Commentary on Twitter (thread – click for more)
In this new piece in @JAMA_current, I teamed up w/ colleague @AndrewMIbrahim to argue that
1) evidence for airborne spread is strong
2) enhanced ventilation/filtration is needed
3) 4-6 air changes per hour should be target for small volume spacesTHREADhttps://t.co/bvdZkyy03j
— Joseph Allen (@j_g_allen) April 16, 2021
A guideline to limit indoor airborne transmission of COVID-19
18 Apr, 2021 | 21:47h | UTC