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Internal Medicine

Randomized trial: No benefit from discontinuing ACE Inhibitors and ARBs in patients admitted with COVID-19

20 Jan, 2021 | 01:55h | UTC

Effect of Discontinuing vs Continuing Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers on Days Alive and Out of the Hospital in Patients Admitted With COVID-19: A Randomized Clinical Trial – JAMA

Commentary: Discontinuing vs. Continuing ACEIs, ARBs in Patients Admitted With COVID-19 – American College of Cardiology

Related study (study and commentary): Randomized trial: Renin–angiotensin system inhibitors can be safely continued in patients admitted to hospital with COVID-19

 


Study: Crowded ICUs linked to increased mortality from COVID-19

20 Jan, 2021 | 01:53h | UTC

Association of Intensive Care Unit Patient Load and Demand With Mortality Rates in US Department of Veterans Affairs Hospitals During the COVID-19 Pandemic – JAMA Network Open

Commentaries: Intensive Care Unit Strain and Mortality Risk Among Critically Ill Patients With COVID-19—There Is No “Me” in COVID – JAMA Network Open AND Crowded ICUs tied to higher risk of COVID-19 death – CIDRAP

 


What we know about Covid-19 reinfection so far

20 Jan, 2021 | 01:52h | UTC

What we know about covid-19 reinfection so far – The BMJ

 

Commentary on Twitter

 


Study: Household transmission of SARS-CoV-2 and risk factors for susceptibility and infectivity

20 Jan, 2021 | 01:49h | UTC

Household transmission of SARS-CoV-2 and risk factors for susceptibility and infectivity in Wuhan: a retrospective observational study – The Lancet Infectious Diseases

Related Report: SARS-CoV-2 setting-specific transmission rates. Households showed the highest transmission rates (21.1%). Asymptomatic infections do occur but much less efficiently than symptomatic infection

 

Commentary on Twitter

 


What we now know — and don’t know — about the coronavirus variants

20 Jan, 2021 | 01:41h | UTC

What we now know — and don’t know — about the coronavirus variants – STAT

Related: Covid-19: What new variants are emerging and how are they being investigated? – The BMJ

 


Systematic review on prophylaxis for COVID-19: Hydroxychloroquine does not work, little evidence regarding other drugs

20 Jan, 2021 | 01:38h | UTC

Prophylaxis for COVID-19: a systematic review – Clinical Microbiology and Infection

 


Randomized trial: Endovascular treatment alone noninferior to intravenous alteplase plus endovascular treatment on functional independence in patients with acute ischemic stroke

20 Jan, 2021 | 01:35h | UTC

Effect of Endovascular Treatment Alone vs Intravenous Alteplase Plus Endovascular Treatment on Functional Independence in Patients With Acute Ischemic Stroke: The DEVT Randomized Clinical Trial – JAMA (free for a limited period)

Related study: Effect of Mechanical Thrombectomy Without vs With Intravenous Thrombolysis on Functional Outcome Among Patients With Acute Ischemic Stroke: The SKIP Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Intravenous Thrombolysis Before Endovascular Thrombectomy for Acute Ischemic Stroke – JAMA (free for a limited period)

Video: Thrombolysis Before Thrombectomy for Stroke

 


USPSTF Statement: Interventions for tobacco smoking cessation in adults

20 Jan, 2021 | 01:32h | UTC

Interventions for Tobacco Smoking Cessation in Adults, Including Pregnant Persons – U.S. Preventive Services Task Force

Editorial: A Comprehensive Approach to Increase Adult Tobacco Cessation – JAMA

Author Interview: USPSTF Recommendation: Tobacco Cessation in Adults

JAMA Patient Page: Interventions to Promote Tobacco Cessation

 


Guideline synopsis: Initiating Pharmacologic Treatment in Tobacco-Dependent Adults

20 Jan, 2021 | 01:31h | UTC

Initiating Pharmacologic Treatment in Tobacco-Dependent Adults – JAMA (free for a limited period)

Author Interview: Pharmacologic Management of Tobacco Cessation

Original Guideline: Initiating Pharmacologic Treatment in Tobacco-Dependent Adults. An Official American Thoracic Society Clinical Practice Guideline – American Journal of Respiratory and Critical Care Medicine

 


An epidemic of overdiagnosis: Melanoma diagnoses sky rocket

20 Jan, 2021 | 01:30h | UTC

An epidemic of overdiagnosis: Melanoma diagnoses sky rocket – Brigham and Women’s Hospital AND Does Screening for Skin Cancer Result in Melanoma Overdiagnosis? – Univadis

Original study: The Rapid Rise in Cutaneous Melanoma Diagnoses ($)

Related: Overdiagnosis: what it is and what it isn’t – BMJ Evidence Based Medicine (free) AND Overdiagnosis across medical disciplines: a scoping review – The BMJ Open (free) AND Too much medical care: bad for you, bad for health care systems – STAT News (free) AND Screening: How overdiagnosis and other harms can undermine the benefits – Health News Review (free) AND Overdiagnosis: causes and consequences in primary health care – Canadian Family Physician (free) AND Five warning signs of overdiagnosis – The Conversation (free) AND What is overdiagnosed cancer? And why does it matter? – Croakey (free) AND Blame rising cancer overdiagnosis on ‘irrational exuberance’ for early detection – STAT (free) AND Preventing overdiagnosis and the harms of too much sport and exercise medicine – British Journal of Sports Medicine (free)

 


Meta-analysis: Early initiation of renal replacement therapy is not associated with survival benefit in critically ill patients with acute kidney injury

20 Jan, 2021 | 01:25h | UTC

Timing of renal replacement therapy initiation for acute kidney injury in critically ill patients: a systematic review of randomized clinical trials with meta-analysis and trial sequential analysis – Critical Care

 


Evidence summary and clinical decision algorithm to guide clinicians in the care of the hypoxemic, non-intubated patients with suspected Covid-19

19 Jan, 2021 | 01:57h | UTC

Knowledge translation tools to guide care of non-intubated patients with acute respiratory illness during the COVID-19 Pandemic – Critical Care

 


Meta-analysis: Corticosteroid use in COVID-19 patients

19 Jan, 2021 | 01:56h | UTC

Corticosteroid use in COVID-19 patients: a systematic review and meta-analysis on clinical outcomes – Critical Care

Related meta-analysis: Corticosteroids for Patients With Coronavirus Disease 2019 (COVID-19) With Different Disease Severity: A Meta-Analysis of Randomized Clinical Trials – Journal of Cardiothoracic and Vascular Anesthesia

 


IDSA: COVID-19 Diagnostic Guidelines Updates

19 Jan, 2021 | 01:54h | UTC

COVID-19 Diagnostic Guidelines Updates (Jan. 16, 2021) – Infectious Diseases Society of America

 


New calculator identifies COVID-19 patients at highest risk of deterioration

19 Jan, 2021 | 01:52h | UTC

Development and validation of the ISARIC 4C Deterioration model for adults hospitalised with COVID-19: a prospective cohort study – The Lancet Respiratory Medicine

Commentaries: Improving clinical management of COVID-19: the role of prediction models – The Lancet Respiratory Medicine

Tool identifies COVID-19 patients at highest risk of deterioration – UK Research and Innovation

See calculator: 4C Mortality & 4C Deterioration

 

Commentary on Twitter

 


Covid-19: What new variants are emerging and how are they being investigated?

19 Jan, 2021 | 01:51h | UTC

Covid-19: What new variants are emerging and how are they being investigated? – The BMJ

 


Can COVID-19 cause diabetes?

19 Jan, 2021 | 01:48h | UTC

Can COVID-19 cause diabetes? – Nature Reviews Endocrinology

Related: COVID-19 and diabetes mellitus: from pathophysiology to clinical management – Nature Reviews Endocrinology

 

Commentary on Twitter

 


Meta-analysis: saliva and nasopharyngeal swab nucleic acid amplification have similar diagnostic accuracy for the detection of SARS-CoV-2

19 Jan, 2021 | 01:46h | UTC

Comparison of Saliva and Nasopharyngeal Swab Nucleic Acid Amplification Testing for Detection of SARS-CoV-2: A Systematic Review and Meta-analysis – JAMA Internal Medicine

Related: The Sensitivity and Costs of Testing for SARS-CoV-2 Infection With Saliva Versus Nasopharyngeal Swabs: A Systematic Review and Meta-analysis – Annals of Internal Medicine

 


Reflection: Against diagnosis

19 Jan, 2021 | 01:38h | UTC

Against diagnosis – The BMJ

 

Commentary on Twitter

 


Podcast: What the USPSTF? Preventive Medicine Updates

19 Jan, 2021 | 01:37h | UTC

#251 What the USPSTF? Preventive Medicine Updates with Dr. Amber-Nicole Bird – The Curbsiders Internal Medicine Podcast

 


Perspective: Addressing polypharmacy in outpatient dialysis units

19 Jan, 2021 | 01:27h | UTC

Addressing Polypharmacy in Outpatient Dialysis Units – Clinical Journal of the American Society of Nephrology

Related: Targeted Deprescribing in an Outpatient Hemodialysis Unit: A Quality Improvement Study to Decrease Polypharmacy – American Journal of Kidney Diseases (link to abstract – $ for full-text)

 


Review: Polypharmacy management in older patients

19 Jan, 2021 | 01:26h | UTC

Polypharmacy Management in Older Patients – Mayo Clinic Proceedings

 


RECOVERY trial: No Benefit from convalescent plasma in hospitalized patients with Covid-19

17 Jan, 2021 | 22:26h | UTC

RECOVERY trial closes recruitment to convalescent plasma treatment for patients hospitalised with COVID-19

Commentary: Covid: ‘Convalescent plasma no benefit to hospital patients’ – BBC

 


Returning to physical activity after Covid-19

17 Jan, 2021 | 22:19h | UTC

Returning to physical activity after covid-19 – The BMJ

Commentary: Returning to physical activity after a Covid-19 infection – Medical Centre

 

Commentaries on Twitter

 


Herd immunity by infection is not an option

17 Jan, 2021 | 22:16h | UTC

Herd immunity by infection is not an option – Science

 


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