Internal Medicine
Randomized trial: No benefit from discontinuing ACE Inhibitors and ARBs in patients admitted with COVID-19
20 Jan, 2021 | 01:55h | UTCCommentary: Discontinuing vs. Continuing ACEIs, ARBs in Patients Admitted With COVID-19 – American College of Cardiology
Related study (study and commentary): Randomized trial: Renin–angiotensin system inhibitors can be safely continued in patients admitted to hospital with COVID-19
Study: Crowded ICUs linked to increased mortality from COVID-19
20 Jan, 2021 | 01:53h | UTCCommentaries: Intensive Care Unit Strain and Mortality Risk Among Critically Ill Patients With COVID-19—There Is No “Me” in COVID – JAMA Network Open AND Crowded ICUs tied to higher risk of COVID-19 death – CIDRAP
What we know about Covid-19 reinfection so far
20 Jan, 2021 | 01:52h | UTCWhat we know about covid-19 reinfection so far – The BMJ
Commentary on Twitter
With most coronaviruses, recovery confers a degree of immunity to reinfection. But a small number of patients have caught #COVID19 for a second time.
What do we know and how worried we should be?https://t.co/NOA0TWAS2g@stokel
— The BMJ (@bmj_latest) January 19, 2021
Study: Household transmission of SARS-CoV-2 and risk factors for susceptibility and infectivity
20 Jan, 2021 | 01:49h | UTC
Commentary on Twitter
A new, very large #SARSCoV2 household transmission study (27K households, 30K cases, 58K contacts)https://t.co/a89uAw3Ohg
—age ≥ 60 and infants most likely to get infected
—<age 20 most likely to infect others (1.6X)@TheLancetInfDis pic.twitter.com/nM044rVEdo— Eric Topol (@EricTopol) January 18, 2021
What we now know — and don’t know — about the coronavirus variants
20 Jan, 2021 | 01:41h | UTCWhat we now know — and don’t know — about the coronavirus variants – STAT
Related: Covid-19: What new variants are emerging and how are they being investigated? – The BMJ
Systematic review on prophylaxis for COVID-19: Hydroxychloroquine does not work, little evidence regarding other drugs
20 Jan, 2021 | 01:38h | UTCProphylaxis for COVID-19: a systematic review – Clinical Microbiology and Infection
Randomized trial: Endovascular treatment alone noninferior to intravenous alteplase plus endovascular treatment on functional independence in patients with acute ischemic stroke
20 Jan, 2021 | 01:35h | UTCEffect of Endovascular Treatment Alone vs Intravenous Alteplase Plus Endovascular Treatment on Functional Independence in Patients With Acute Ischemic Stroke: The DEVT Randomized Clinical Trial – JAMA (free for a limited period)
Related study: Effect of Mechanical Thrombectomy Without vs With Intravenous Thrombolysis on Functional Outcome Among Patients With Acute Ischemic Stroke: The SKIP Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Intravenous Thrombolysis Before Endovascular Thrombectomy for Acute Ischemic Stroke – JAMA (free for a limited period)
Video: Thrombolysis Before Thrombectomy for Stroke
USPSTF Statement: Interventions for tobacco smoking cessation in adults
20 Jan, 2021 | 01:32h | UTCEditorial: A Comprehensive Approach to Increase Adult Tobacco Cessation – JAMA
Author Interview: USPSTF Recommendation: Tobacco Cessation in Adults
JAMA Patient Page: Interventions to Promote Tobacco Cessation
Guideline synopsis: Initiating Pharmacologic Treatment in Tobacco-Dependent Adults
20 Jan, 2021 | 01:31h | UTCInitiating Pharmacologic Treatment in Tobacco-Dependent Adults – JAMA (free for a limited period)
Author Interview: Pharmacologic Management of Tobacco Cessation
An epidemic of overdiagnosis: Melanoma diagnoses sky rocket
20 Jan, 2021 | 01:30h | UTCAn epidemic of overdiagnosis: Melanoma diagnoses sky rocket – Brigham and Women’s Hospital AND Does Screening for Skin Cancer Result in Melanoma Overdiagnosis? – Univadis
Original study: The Rapid Rise in Cutaneous Melanoma Diagnoses ($)
Related: Overdiagnosis: what it is and what it isn’t – BMJ Evidence Based Medicine (free) AND Overdiagnosis across medical disciplines: a scoping review – The BMJ Open (free) AND Too much medical care: bad for you, bad for health care systems – STAT News (free) AND Screening: How overdiagnosis and other harms can undermine the benefits – Health News Review (free) AND Overdiagnosis: causes and consequences in primary health care – Canadian Family Physician (free) AND Five warning signs of overdiagnosis – The Conversation (free) AND What is overdiagnosed cancer? And why does it matter? – Croakey (free) AND Blame rising cancer overdiagnosis on ‘irrational exuberance’ for early detection – STAT (free) AND Preventing overdiagnosis and the harms of too much sport and exercise medicine – British Journal of Sports Medicine (free)
Meta-analysis: Early initiation of renal replacement therapy is not associated with survival benefit in critically ill patients with acute kidney injury
20 Jan, 2021 | 01:25h | UTC
Evidence summary and clinical decision algorithm to guide clinicians in the care of the hypoxemic, non-intubated patients with suspected Covid-19
19 Jan, 2021 | 01:57h | UTC
Meta-analysis: Corticosteroid use in COVID-19 patients
19 Jan, 2021 | 01:56h | UTCRelated meta-analysis: Corticosteroids for Patients With Coronavirus Disease 2019 (COVID-19) With Different Disease Severity: A Meta-Analysis of Randomized Clinical Trials – Journal of Cardiothoracic and Vascular Anesthesia
IDSA: COVID-19 Diagnostic Guidelines Updates
19 Jan, 2021 | 01:54h | UTCCOVID-19 Diagnostic Guidelines Updates (Jan. 16, 2021) – Infectious Diseases Society of America
New calculator identifies COVID-19 patients at highest risk of deterioration
19 Jan, 2021 | 01:52h | UTCCommentaries: Improving clinical management of COVID-19: the role of prediction models – The Lancet Respiratory Medicine
Tool identifies COVID-19 patients at highest risk of deterioration – UK Research and Innovation
See calculator: 4C Mortality & 4C Deterioration
Commentary on Twitter
This model helps predict clinical deterioration of hospitalized patients with #COVID19 using 11 commonly measured/identifiable variables at the time of hospital contact.
Validated on ~75000 patients from 260 hospitals in the UK.
Nice.
By @Rishi_K_Gupta: https://t.co/OX8vtLtcVY pic.twitter.com/FEs5gZ9M5U
— Isaac Bogoch (@BogochIsaac) January 13, 2021
Covid-19: What new variants are emerging and how are they being investigated?
19 Jan, 2021 | 01:51h | UTCCovid-19: What new variants are emerging and how are they being investigated? – The BMJ
Can COVID-19 cause diabetes?
19 Jan, 2021 | 01:48h | UTCCan COVID-19 cause diabetes? – Nature Reviews Endocrinology
Commentary on Twitter
Can #COVID19 induce #diabetes?
We don't know if #SARSCoV2 can directly damage pancreatic β-islet cells.
"If covid-19 were in fact to cause permanent insulin-dependent diabetes, SARS-CoV-2 would be unique." https://t.co/EMjW7d4Azv @NatMetabolism @ColumbiaMed Domenico Accili pic.twitter.com/HpNe9IToGm— Eric Topol (@EricTopol) January 12, 2021
Meta-analysis: saliva and nasopharyngeal swab nucleic acid amplification have similar diagnostic accuracy for the detection of SARS-CoV-2
19 Jan, 2021 | 01:46h | UTC
Reflection: Against diagnosis
19 Jan, 2021 | 01:38h | UTC
Commentary on Twitter
Diagnosis lies at the heart of medicine. But is it all it’s cracked up to be? Sometimes a diagnosis can be confusing, stigmatising, frightening, unnecessary – or just plain wrong. My latest piece @PMJ_BMJ.https://t.co/LPAScmLBRY
— John Launer (@JohnLauner) January 16, 2021
Podcast: What the USPSTF? Preventive Medicine Updates
19 Jan, 2021 | 01:37h | UTC
Perspective: Addressing polypharmacy in outpatient dialysis units
19 Jan, 2021 | 01:27h | UTCRelated: Targeted Deprescribing in an Outpatient Hemodialysis Unit: A Quality Improvement Study to Decrease Polypharmacy – American Journal of Kidney Diseases (link to abstract – $ for full-text)
Review: Polypharmacy management in older patients
19 Jan, 2021 | 01:26h | UTCPolypharmacy Management in Older Patients – Mayo Clinic Proceedings
RECOVERY trial: No Benefit from convalescent plasma in hospitalized patients with Covid-19
17 Jan, 2021 | 22:26h | UTCCommentary: Covid: ‘Convalescent plasma no benefit to hospital patients’ – BBC
Returning to physical activity after Covid-19
17 Jan, 2021 | 22:19h | UTCReturning to physical activity after covid-19 – The BMJ
Commentary: Returning to physical activity after a Covid-19 infection – Medical Centre
Commentaries on Twitter
"Returning to #PhysicalActivity after #COVIDー19 should be gradual, individualised, and based on subjective tolerance of the activity.".#exercise #rehab
⛹️♀️🏃⚽🎾🏌️🏋️♂️🏊♀️🚴♂️🤸♀️🏸🤼
HT- @bmj_latesthttps://t.co/GnqwCBkZRN pic.twitter.com/k4nsDI6ApU
— Christopher Tuckett (@HealthPhysio) January 15, 2021
Professional experience suggests that after mild suspected covid-19 a proportion of people experience a prolonged recovery. What are the risks of physical activity after covid-19 and how to know if a patient can safely return to physical exercise?https://t.co/19Cfi4p5Ck
— The BMJ (@bmj_latest) January 11, 2021
Herd immunity by infection is not an option
17 Jan, 2021 | 22:16h | UTCHerd immunity by infection is not an option – Science