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Pediatrics – Neonatal/Perinatal

How do we make decisions for the most immature babies, with their families?

20 Jan, 2022 | 08:49h | UTC

How do we make decisions for the most immature babies, with their families? – Neonatal Research

 

RCT: In full-term and near-term neonates, drug treatment of all clinically and electrographically detected seizures was not associated with reduced death rates or disability at 2 years compared with the treatment of only the clinically detected seizures.

13 Jan, 2022 | 08:24h | UTC

Effect of Treatment of Clinical Seizures vs Electrographic Seizures in Full-Term and Near-Term Neonates: A Randomized Clinical Trial – JAMA Network Open

Commentaries:

Should we treat electrographic seizures? – Neonatal Research

Subclinical Electrographic Seizures in the Newborn—Is More Treatment Better? – JAMA Network Open

Neonatal Seizures: Little Difference Between EEG/Clinical Treatment – Physician’s Weekly

 

Commentary on Twitter

 

Clinical Update: Management and outcomes of extreme preterm birth.

12 Jan, 2022 | 08:48h | UTC

Management and outcomes of extreme preterm birth – The BMJ

 

RCT: In preterm infants with respiratory distress syndrome, surfactant administration via a thin catheter did not improve outcomes.

15 Dec, 2021 | 08:26h | UTC

Effect of Minimally Invasive Surfactant Therapy vs Sham Treatment on Death or Bronchopulmonary Dysplasia in Preterm Infants With Respiratory Distress Syndrome: The OPTIMIST-A Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Minimally Invasive Surfactant Therapy to Prevent Bronchopulmonary Dysplasia in Extremely Preterm Infants – JAMA (free for a limited period)

Video: Demonstration of the Hobart Method of Minimally Invasive Surfactant Therapy in a Resuscitation Manikin Equivalent to a 27-Week Gestation 1-kg Preterm Infant – JAMA

 

Retrospective study: antimicrobial susceptibility profiles among neonatal early-onset sepsis (EOS) pathogens – “The vast majority of contemporary EOS pathogens are susceptible to the combination of ampicillin and gentamicin”.

14 Dec, 2021 | 08:46h | UTC

Antimicrobial Susceptibility Profiles Among Neonatal Early-onset Sepsis Pathogens – The Pediatric Infectious Disease Journal

 

Commentary on Twitter

 

NICE Guideline | Inducing labor.

13 Dec, 2021 | 08:55h | UTC

Inducing labour – National Institute for Health and Care Excellence

Related: NICE recommends offering women induced labor earlier in new draft guidance – “women with uncomplicated singleton pregnancies should be offered induction at 41 weeks and the induction should take place as soon as possible. Previous guidelines advised induction between 41 and 42 weeks”.

 

Two-year follow up of randomized trial shows delaying umbilical cord clamping saves preterm babies’ lives.

13 Dec, 2021 | 08:46h | UTC

News Release: Two-year follow up shows delaying umbilical cord clamping saves babies’ lives – University of Sydney

Original Article: Effects of delayed versus immediate umbilical cord clamping in reducing death or major disability at 2 years corrected age among very preterm infants (APTS): a multicentre, randomised clinical trial – The Lancet Child & Adolescent Health

Related:

Systematic Review: Delayed Cord Clamping May Reduce the Risk of Death Before Discharge for Babies Born Preterm

Delayed vs early umbilical cord clamping for preterm infants: a systematic review and meta-analysis – American Journal of Obstetrics & Gynecology

 

Commentaries on Twitter

 

Systematic Review: Early (started within six days) systemic postnatal corticosteroids for preventing bronchopulmonary dysplasia in preterm infants.

1 Dec, 2021 | 08:33h | UTC

Summary: Early (started within six days) systemic postnatal corticosteroids for preventing bronchopulmonary dysplasia in preterm infants – Cochrane Library

Original Study: Early (< 7 days) systemic postnatal corticosteroids for prevention of bronchopulmonary dysplasia in preterm infants – Cochrane Library

 

Commentary on Twitter

 

Systematic Review: Late (after 6 days) systemic postnatal corticosteroids for prevention of bronchopulmonary dysplasia in preterm infants.

1 Dec, 2021 | 08:32h | UTC

Late (≥ 7 days) systemic postnatal corticosteroids for prevention of bronchopulmonary dysplasia in preterm infants – Cochrane Library

 

Extravasation injuries of the limbs in neonates and children: development of a treatment algorithm.

28 Nov, 2021 | 21:03h | UTC

Extravasation Injuries of the Limbs in Neonates and Children: Development of a Treatment Algorithm – Deutsches Ärzteblatt International

 

AAP Clinical Report: Promoting Human Milk and Breastfeeding for the Very Low Birth Weight Infant.

19 Nov, 2021 | 10:35h | UTC

Promoting Human Milk and Breastfeeding for the Very Low Birth Weight Infant – Pediatrics

 

Pro-Con Debate: Should all babies have their genome sequenced at birth?

19 Nov, 2021 | 10:19h | UTC

Should all babies have their genome sequenced at birth? – The BMJ

Related:

RCT: Effect of whole-genome sequencing on the clinical management of acutely ill infants with suspected genetic disease.

Whole genome sequencing may improve the diagnosis of rare diseases and shorten diagnostic journeys for patients.

Review: Genome sequencing as a diagnostic test.

 

Systematic Review: Avoidance of bottles during the establishment of breastfeeds in preterm infants – “Avoiding the use of bottles when preterm infants need supplementary feeds probably increases the extent of any breastfeeding at discharge”.

28 Oct, 2021 | 09:56h | UTC

Avoidance of bottles during the establishment of breastfeeds in preterm infants – Cochrane Library

Summary: Avoidance of bottles during the establishment of breastfeeds in preterm infants – Cochrane Library

 

A case-controlled study showed Covid-19 vaccination during early pregnancy was not associated with increased risk of first-trimester miscarriage.

21 Oct, 2021 | 10:14h | UTC

Covid-19 Vaccination during Pregnancy and First-Trimester Miscarriage – New England Journal of Medicine

Related:

Editorial: Covid-19 treatments and vaccines must be evaluated in pregnancy.

Cohort study: Vaccinated pregnant patients had 90% lower risk of severe or critical Covid-19 compared with unvaccinated pregnant patients.

Two observational studies suggest spontaneous abortion is not increased following COVID-19 mRNA vaccination during pregnancy.

Study shows high effectiveness of the Pfizer mRNA COVID-19 vaccine in pregnancy.

5 Crucial Things to Know About COVID-19 Vaccines and Pregnancy.

CDC Guidance: Pregnant people should be vaccinated against COVID-19.

ACOG and SMFM Recommend COVID-19 Vaccination for Pregnant Individuals – “ACOG encourages its members to enthusiastically recommend vaccination to their patients.”

Cohort study: Pfizer/BioNTech COVID vaccine associated with 78% lower risk of Covid-19 in pregnancy.

 

Systematic Review: “Formula milk trials have a high risk of bias, almost always report favorable conclusions, lack transparency, and selectively report findings”.

15 Oct, 2021 | 02:25h | UTC

News release: Formula milk trials are not reliable, warn researchers – Imperial College London

Original study: Conduct and reporting of formula milk trials: systematic review – The BMJ

 

RCT: Effect of whole-genome sequencing on the clinical management of acutely ill infants with suspected genetic disease.

28 Sep, 2021 | 09:05h | UTC

Effect of Whole-Genome Sequencing on the Clinical Management of Acutely Ill Infants With Suspected Genetic Disease: A Randomized Clinical Trial – JAMA Pediatrics

 

Commentaries on Twitter

 

Supplement: FIGO Working Group for Preterm Birth – Good Practice Recommendations.

15 Sep, 2021 | 08:56h | UTC

Homepage: FIGO Working Group for Preterm Birth – Good Practice Recommendations – International Journal of Gynecology & Obstetrics

Editorial: FIGO good practice recommendations for reducing preterm birth and improving child outcomes

FIGO good practice recommendations on the importance of registry data for monitoring rates and health systems performance in prevention and management of preterm birth

FIGO good practice recommendations on modifiable causes of iatrogenic preterm birth

FIGO good practice recommendations on reduction of preterm birth in pregnancies conceived by assisted reproductive technologies

FIGO good practice recommendations on progestogens for prevention of preterm delivery

FIGO good practice recommendations on cervical cerclage for prevention of preterm birth

FIGO good practice recommendations on the use of pessary for reducing the frequency and improving outcomes of preterm birth

FIGO good practice recommendations on the use of prenatal corticosteroids to improve outcomes and minimize harm in babies born preterm

FIGO good practice recommendations on magnesium sulfate administration for preterm fetal neuroprotection

FIGO good practice recommendations on delayed umbilical cord clamping

 

Study shows high effectiveness of the Pfizer mRNA COVID-19 vaccine in pregnancy.

7 Sep, 2021 | 21:48h | UTC

Effectiveness of the BNT162b2 mRNA COVID-19 vaccine in pregnancy – Nature Medicine

 

Commentaries on Twitter

 

Study casts doubt on WHO guidance on antibiotics for neonatal sepsis.

3 Sep, 2021 | 09:57h | UTC

Study casts doubt on WHO guidance on antibiotics for neonatal sepsis – CIDRAP

Original study: Effects of antibiotic resistance, drug target attainment, bacterial pathogenicity and virulence, and antibiotic access and affordability on outcomes in neonatal sepsis: an international microbiology and drug evaluation prospective substudy (BARNARDS) – The Lancet Infectious Diseases

Invited commentary: Antibiotics for neonatal sepsis in low-income and middle-income countries—where to go from here? (free registration required)

 

Commentary on Twitter

 

The Role of Lung Ultrasound in the Management of the Critically Ill Neonate—A Narrative Review and Practical Guide.

3 Sep, 2021 | 10:00h | UTC

The Role of Lung Ultrasound in the Management of the Critically Ill Neonate—A Narrative Review and Practical Guide – Children

 

Global, regional, and national estimates and trends in stillbirths from 2000 to 2019: a systematic assessment.

1 Sep, 2021 | 08:56h | UTC

Global, regional, and national estimates and trends in stillbirths from 2000 to 2019: a systematic assessment – The Lancet

 

Preventing stillbirth: What’s the latest evidence?

25 Aug, 2021 | 08:38h | UTC

Preventing stillbirth: What’s the latest evidence? – Evidently Cochrane

Special collection: Stillbirth prevention and respectful bereavement care – Cochrane Library

 

Commentary on Twitter (thread – click for more)

 

NICE Guideline: Antenatal care.

19 Aug, 2021 | 08:53h | UTC

Antenatal care – National Institutes for Health and Care Excellence

 

Doubts raised about cooling treatment for oxygen-deprived newborns.

19 Aug, 2021 | 08:38h | UTC

Doubts raised about cooling treatment for oxygen-deprived newborns – Nature

Original study: RCT: Therapeutic hypothermia may cause harm in moderate or severe neonatal encephalopathy in low-income and middle-income countries.

 

RCT: Therapeutic hypothermia may cause harm in moderate or severe neonatal encephalopathy in low-income and middle-income countries.

5 Aug, 2021 | 08:43h | UTC

Hypothermia for moderate or severe neonatal encephalopathy in low-income and middle-income countries (HELIX): a randomised controlled trial in India, Sri Lanka, and Bangladesh – The Lancet Global Health

News release: Brain injury treatment may cause harm in low and middle income nations – Imperial College London

Commentary: Hypoxic ischaemic encephalopathy in low resource settings—time to stop cooling? – The Lancet Global Health

 

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