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Pediatrics – Neonatal/Perinatal

Systematic Review: “Formula milk trials have a high risk of bias, almost always report favorable conclusions, lack transparency, and selectively report findings”.

15 Oct, 2021 | 02:25h | UTC

News release: Formula milk trials are not reliable, warn researchers – Imperial College London

Original study: Conduct and reporting of formula milk trials: systematic review – The BMJ

 

RCT: Effect of whole-genome sequencing on the clinical management of acutely ill infants with suspected genetic disease.

28 Sep, 2021 | 09:05h | UTC

Effect of Whole-Genome Sequencing on the Clinical Management of Acutely Ill Infants With Suspected Genetic Disease: A Randomized Clinical Trial – JAMA Pediatrics

 

Commentaries on Twitter

 

Supplement: FIGO Working Group for Preterm Birth – Good Practice Recommendations.

15 Sep, 2021 | 08:56h | UTC

Homepage: FIGO Working Group for Preterm Birth – Good Practice Recommendations – International Journal of Gynecology & Obstetrics

Editorial: FIGO good practice recommendations for reducing preterm birth and improving child outcomes

FIGO good practice recommendations on the importance of registry data for monitoring rates and health systems performance in prevention and management of preterm birth

FIGO good practice recommendations on modifiable causes of iatrogenic preterm birth

FIGO good practice recommendations on reduction of preterm birth in pregnancies conceived by assisted reproductive technologies

FIGO good practice recommendations on progestogens for prevention of preterm delivery

FIGO good practice recommendations on cervical cerclage for prevention of preterm birth

FIGO good practice recommendations on the use of pessary for reducing the frequency and improving outcomes of preterm birth

FIGO good practice recommendations on the use of prenatal corticosteroids to improve outcomes and minimize harm in babies born preterm

FIGO good practice recommendations on magnesium sulfate administration for preterm fetal neuroprotection

FIGO good practice recommendations on delayed umbilical cord clamping

 

Study shows high effectiveness of the Pfizer mRNA COVID-19 vaccine in pregnancy.

7 Sep, 2021 | 21:48h | UTC

Effectiveness of the BNT162b2 mRNA COVID-19 vaccine in pregnancy – Nature Medicine

 

Commentaries on Twitter

 

The Role of Lung Ultrasound in the Management of the Critically Ill Neonate—A Narrative Review and Practical Guide.

3 Sep, 2021 | 10:00h | UTC

The Role of Lung Ultrasound in the Management of the Critically Ill Neonate—A Narrative Review and Practical Guide – Children

 

Study casts doubt on WHO guidance on antibiotics for neonatal sepsis.

3 Sep, 2021 | 09:57h | UTC

Study casts doubt on WHO guidance on antibiotics for neonatal sepsis – CIDRAP

Original study: Effects of antibiotic resistance, drug target attainment, bacterial pathogenicity and virulence, and antibiotic access and affordability on outcomes in neonatal sepsis: an international microbiology and drug evaluation prospective substudy (BARNARDS) – The Lancet Infectious Diseases

Invited commentary: Antibiotics for neonatal sepsis in low-income and middle-income countries—where to go from here? (free registration required)

 

Commentary on Twitter

 

Global, regional, and national estimates and trends in stillbirths from 2000 to 2019: a systematic assessment.

1 Sep, 2021 | 08:56h | UTC

Global, regional, and national estimates and trends in stillbirths from 2000 to 2019: a systematic assessment – The Lancet

 

Preventing stillbirth: What’s the latest evidence?

25 Aug, 2021 | 08:38h | UTC

Preventing stillbirth: What’s the latest evidence? – Evidently Cochrane

Special collection: Stillbirth prevention and respectful bereavement care – Cochrane Library

 

Commentary on Twitter (thread – click for more)

 

NICE Guideline: Antenatal care.

19 Aug, 2021 | 08:53h | UTC

Antenatal care – National Institutes for Health and Care Excellence

 

Doubts raised about cooling treatment for oxygen-deprived newborns.

19 Aug, 2021 | 08:38h | UTC

Doubts raised about cooling treatment for oxygen-deprived newborns – Nature

Original study: RCT: Therapeutic hypothermia may cause harm in moderate or severe neonatal encephalopathy in low-income and middle-income countries.

 

RCT: Therapeutic hypothermia may cause harm in moderate or severe neonatal encephalopathy in low-income and middle-income countries.

5 Aug, 2021 | 08:43h | UTC

Hypothermia for moderate or severe neonatal encephalopathy in low-income and middle-income countries (HELIX): a randomised controlled trial in India, Sri Lanka, and Bangladesh – The Lancet Global Health

News release: Brain injury treatment may cause harm in low and middle income nations – Imperial College London

Commentary: Hypoxic ischaemic encephalopathy in low resource settings—time to stop cooling? – The Lancet Global Health

 

Commentary on the Latest AAP Guidelines for the Febrile Neonate.

5 Aug, 2021 | 08:36h | UTC

Small Talk – Hot Off The Presses: The Latest AAP Guidelines for the Febrile Neonate – emDocs

Original guideline:

AAP Guideline: Evaluation and management of well-appearing febrile infants 8 to 60 days old.

Related:

M-A: Low prevalence of bacterial meningitis among well-appearing febrile infants aged 29-60 days with positive urinalysis results – “These results suggest that for these infants, the decision to use lumbar puncture should not be guided by urinalysis results alone”.

Things We Do for No Reason: Lumbar Punctures in Low-Risk Febrile Infants with Bronchiolitis

[Abstract Only] Observational Study Suggests Testing for Meningitis May Not be Necessary for Febrile Well-Appearing Young Infants with Positive Urinalysis

Study: Clinical Prediction Rule to Identify Febrile Infants at Low Risk for Serious Bacterial Infections

Cohort Study: Accuracy of Complete Blood Cell Counts to Identify Febrile Infants 60 Days or Younger With Invasive Bacterial Infections

 

RCT: Among pregnant women with primary CMV infection diagnosed before 24 weeks’ gestation, monthly infusion of CMV hyperimmune globulin did not prevent congenital cytomegalovirus infection.

30 Jul, 2021 | 11:42h | UTC

A Trial of Hyperimmune Globulin to Prevent Congenital Cytomegalovirus Infection – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Hyperimmune Globulin Fails to Prevent Congenital CMV – Physician’s Weekly

 

Effect of systemic hydrocortisone initiated 7 to 14 days after birth in ventilated preterm infants on mortality and neurodevelopment at 2 years’ corrected age: follow-up of a randomized clinical trial.

29 Jul, 2021 | 10:57h | UTC

Effect of Systemic Hydrocortisone Initiated 7 to 14 Days After Birth in Ventilated Preterm Infants on Mortality and Neurodevelopment at 2 Years’ Corrected Age: Follow-up of a Randomized Clinical Trial – JAMA (free for a limited period)

 

RCT showed improved outcomes with fetal surgery for severe left diaphragmatic hernia.

5 Jul, 2021 | 01:53h | UTC

Randomized Trial of Fetal Surgery for Severe Left Diaphragmatic Hernia – New England Journal of Medicine (link to abstract – $ for full-text – Full text can be found here)

Commentary: Fetal Surgery Boosts Survival for Babies With Severe Birth Defect – MedPage Today (free registration required)

 

Widespread implementation of a low-cost telehealth service in the delivery of antenatal care during the COVID-19 pandemic enabled the reduction of in-person consultations by 50% without compromising pregnancy outcomes.

2 Jul, 2021 | 11:26h | UTC

Widespread implementation of a low-cost telehealth service in the delivery of antenatal care during the COVID-19 pandemic: an interrupted time-series analysis – The Lancet

Commentary: Expanding the concept of safety in antenatal care provision – The Lancet

 

WHO: Caesarean section rates continue to rise, amid growing inequalities in access.

18 Jun, 2021 | 08:23h | UTC

Caesarean section rates continue to rise, amid growing inequalities in access – World Health Organization

Original study: Trends and projections of caesarean section rates: global and regional estimates – BMJ Global Health

 

Commentary on Twitter (thread – click for more)

 

M-A: Delivery room interventions for hypothermia in preterm neonates – “use of a plastic bag or wrap with a plastic cap or with heated humidified gas was associated with lower risk of major brain injury and mortality”.

1 Jun, 2021 | 08:10h | UTC

Delivery Room Interventions for Hypothermia in Preterm Neonates: A Systematic Review and Network Meta-analysis – JAMA Pediatrics (link to abstract – $ for full-text)

 

Study suggests it is safe to discontinue antiseizure medication for most neonates with acute symptomatic seizures prior to discharge from the hospital.

27 May, 2021 | 08:14h | UTC

Safety of Early Discontinuation of Antiseizure Medication After Acute Symptomatic Neonatal Seizures – JAMA Neurology (free for a limited period)

Editorial: Discontinuing Antiseizure Medication in Neonates With Acute Symptomatic Seizures—Primum non nocere – JAMA Neurology (free for a limited period)

Commentaries: Stopping Antiseizure Medication After Acute Symptomatic Neonatal Seizures Is Found to Be Safe – Neurology Today AND Babies with Seizures May Be Overmedicated – Michigan Medicine

 

Commentary on Twitter

 

RCT: Immediate “kangaroo mother care” improves survival in infants with low birth weight compared to conventional care with “kangaroo mother care” initiated after stabilization.

27 May, 2021 | 08:18h | UTC

Immediate “Kangaroo Mother Care” and Survival of Infants with Low Birth Weight – New England Journal of Medicine

Commentary: Immediate skin-to-skin contact after birth improves survival of pre-term babies – Karolisnka Institutet

Related: RCT: Community-initiated kangaroo mother care reduced the risk of moderate-to-severe maternal postpartum depressive symptoms among mothers of low-birth-weight infants in low-income areas in India AND WHO: New research highlights risks of separating newborns from mothers during COVID-19 pandemic AND Randomized Trial: Kangaroo Mother Care Improves Survival of Infants with Low Birthweight

 

Systematic Review: Oral dextrose gel reduces the risk of neonatal hypoglycemia in at‐risk infants and probably reduces the risk of major neurological disability at two years.

25 May, 2021 | 08:38h | UTC

Oral dextrose gel to prevent hypoglycaemia in at‐risk neonates – Cochrane Library

Summary: Oral dextrose gel for prevention of low blood glucose levels in newborn babies – Cochrane Library

 

Systematic Review: Surfactant therapy via thin catheter in preterm infants with or at risk of respiratory distress syndrome is associated with reduced risk of death or bronchopulmonary dysplasia, less intubation in the first 72 hours, and reduced incidence of major complications and in‐hospital mortality.

19 May, 2021 | 08:20h | UTC

Surfactant therapy via thin catheter in preterm infants with or at risk of respiratory distress syndrome – Cochrane Library

Summary: Surfactant therapy via thin catheter in preterm infants with or at risk of respiratory distress syndrome – Cochrane Library

 

Commentary on Twitter

 

WHO: New report sounds the alarm on global shortage of 900 000 midwives.

6 May, 2021 | 08:45h | UTC

New report sounds the alarm on global shortage of 900 000 midwives – World Health Organization

Report: The State of the World’s Midwifery 2021 – UN sexual and reproductive health agency

 

Commentary on Twitter (thread – click for more)

 

Cohort study: Risk of developmental difficulties remains high among children born early

5 May, 2021 | 08:24h | UTC

Neurodevelopmental outcomes at age 5 among children born preterm: EPIPAGE-2 cohort study – The BMJ

News release: Risk of developmental difficulties remains high among children born early – The BMJ

 

Commentary on Twitter

 

RCT: Community-initiated kangaroo mother care reduced the risk of moderate-to-severe maternal postpartum depressive symptoms among mothers of low-birth-weight infants in low-income areas in India

5 May, 2021 | 08:21h | UTC

Effect of Community-Initiated Kangaroo Mother Care on Postpartum Depressive Symptoms and Stress Among Mothers of Low-Birth-Weight Infants: A Randomized Clinical Trial – JAMA Network Open

 

Commentary on Twitter

 

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