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Endocrinology

Podcast: Diabetes Triple Distilled. Pitfalls of A1c testing, different guidelines for A1C targets, when and how to use the newer medications such as SGLT-2 inhibitors and GLP-1 agonists, and more

24 Nov, 2020 | 09:03h | UTC

#243 Diabetes Triple Distilled – The Curbsiders Internal Medicine Podcast

 


Systematic review: Ultra-long‐acting insulins provide modest benefit compared to NPH insulin for Type 2 DM, resulting in reduced risk of hypoglycemia but no difference in HbA1c

23 Nov, 2020 | 09:45h | UTC

(Ultra‐)long‐acting insulin analogues versus NPH insulin (human isophane insulin) for adults with type 2 diabetes mellitus – Cochrane Library

Summary: (Ultra-)long-acting insulin analogues compared with NPH insulin (human isophane insulin) for adults with type 2 diabetes mellitus

 


#AHA20 – RCT: Sotagliflozin improved cardiovascular outcomes in patients with Diabetes and CKD. Diarrhea, genital mycotic infections, volume depletion, and diabetic ketoacidosis were more common with sotagliflozin than with placebo

18 Nov, 2020 | 09:08h | UTC

Sotagliflozin in Patients with Diabetes and Chronic Kidney Disease – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Effect of Sotagliflozin on Cardiovascular and Renal Events in Patients With Type 2 Diabetes and Moderate Renal Impairment Who Are at Cardiovascular Risk – SCORED – American College of Cardiology

 


#AHA20 – RCT: Sotagliflozin improved cardiovascular outcomes in patients with Diabetes and Recent Worsening Heart Failure. Diarrhea and severe hypoglycemia were more common with sotagliflozin than with placebo

18 Nov, 2020 | 09:06h | UTC

Sotagliflozin in Patients with Diabetes and Recent Worsening Heart Failure – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Effect of Sotagliflozin on Cardiovascular Events in Patients With Type 2 Diabetes Post Worsening Heart Failure – SOLOIST-WHF – American College of Cardiology

 


Opinion: A new important study supports wider use of the polypill

18 Nov, 2020 | 09:01h | UTC

Richard Smith: A new important study supports wider use of the polypill – The Lancet

Original study and commentaries: Randomized trial: A polypill comprising statins, multiple blood pressure lowering drugs, and aspirin prevents cardiovascular events among patients at intermediate cardiovascular risk

 

Commentary on Twitter

 


[Abstract Only] In a Phase 2 randomized trial, Semaglutide at high doses improved Nonalcoholic Steatohepatitis (NASH), but with no significant beneficial effects in liver fibrosis

17 Nov, 2020 | 09:31h | UTC

A Placebo-Controlled Trial of Subcutaneous Semaglutide in Nonalcoholic Steatohepatitis – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Semaglutide Shows Promise in NASH Phase 2 Study – Medscape (free registration required)

 

Commentary on Twitter

 


#AHA20 – Randomized trial: In patients with refractory hypercholesterolemia, the use of Evinacumab significantly reduced the LDL levels. Larger studies with patient-relevant outcomes are needed.

16 Nov, 2020 | 01:59h | UTC

Evinacumab in Patients with Refractory Hypercholesterolemia – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Evinacumab in Patients With Refractory Hypercholesterolemia – Evinacumab for Refractory Hypercholesterolemia – American College of Cardiology

 

Commentary on Twitter

 


#AHA20 – In patients who had discontinued statins because of side effects, a N-of-1 trial of a statin, placebo, or no treatment found that side effects often attributed to statins were the same for those taking a placebo

16 Nov, 2020 | 01:57h | UTC

Side effects often attributed to statins were the same for those taking a placebo – American Heart Association

Commentary: ‘Nocebo effect’ cause of most statin side-effects, study suggests – The Guardian

Original study: N-of-1 Trial of a Statin, Placebo, or No Treatment to Assess Side Effects – New England Journal of Medicine ($ – no abstract available)

 

Commentary on Twitter

 


#AHA20 – Randomized trial: High-dose Omega-3 fatty acids did not reduce the risk of cardiac events in patients at high cardiovascular risk

16 Nov, 2020 | 01:51h | UTC

Effect of High-Dose Omega-3 Fatty Acids vs Corn Oil on Major Adverse Cardiovascular Events in Patients at High Cardiovascular Risk: The STRENGTH Randomized Clinical Trial – JAMA

Editorial 1: Effects of Omega-3 Fatty Acids on Major Adverse Cardiovascular Events: What Matters Most: the Drug, the Dose, or the Placebo?

Editorial 2: Do Omega-3 Fatty Acids Benefit Health?

Commentary: STRENGTH trial finds new fish oil medication did not reduce the risk of cardiac events – American Heart Association

 

Commentary on Twitter

 


[Not Published Yet] #AHA20 – Randomized trial: Fish oil and vitamin D supplements not effective for preventing atrial fibrillation

16 Nov, 2020 | 01:49h | UTC

Fish oil and vitamin D supplements not effective for preventing atrial fibrillation – American Heart Association

Commentary: Fish Oil, Vitamin D Don’t Prevent A-fib: VITAL Rhythm – TCTMD

 


World Diabetes Day 2020 (14 November 2020): Introducing the Global Diabetes Compact

16 Nov, 2020 | 01:43h | UTC

World Diabetes Day 2020: Introducing the Global Diabetes Compact – World Health Organization

See also: WHO Global Diabetes Compact

Related: The Lancet Commission on diabetes: using data to transform diabetes care and patient lives (free registration required) AND Editorial: Turning evidence into action on diabetes – The Lancet

 

Commentary on Twitter (thread – click for more)

 


KDIGO Guideline Synopsis: Diabetes management in chronic kidney disease. Use of ACE inhibitors or ARBs, glycemic monitoring and targets, and choice of antihyperglycemic drugs are covered

11 Nov, 2020 | 09:09h | UTC

Diabetes Management in Chronic Kidney Disease: Synopsis of the 2020 KDIGO Clinical Practice Guideline – Annals of Internal Medicine

Original guideline: Kidney Disease: Improving Global Outcomes (KDIGO) 2020 Clinical Practice Guideline for Diabetes Management in Chronic Kidney Disease

 


Perioperative evaluation and management of patients with diabetes, thyroid disease, and adrenal insufficiency. Use of insulin and noninsulin diabetic medications, management of hyper and hypothyroidism, and use of stress-dose corticosteroids are some of the subjects reviewed

10 Nov, 2020 | 09:24h | UTC

Perioperative Evaluation and Management of Endocrine Disorders – Mayo Clinic Proceedings

 


Low carbohydrate diet: Insights from a general practice service in patients with type 2 diabetes

4 Nov, 2020 | 09:38h | UTC

Insights from a general practice service evaluation supporting a lower carbohydrate diet in patients with type 2 diabetes mellitus and prediabetes: a secondary analysis of routine clinic data including HbA1c, weight and prescribing over 6 years – BMJ Nutrition, Prevention & Health

 

Commentary on Twitter

 


Social determinants of health and diabetes: A scientific review

3 Nov, 2020 | 03:07h | UTC

Social Determinants of Health and Diabetes: A Scientific Review – Diabetes Care

 


Cohort study: Dietary inflammatory potential and risk of cardiovascular disease among men and women in the U.S.

3 Nov, 2020 | 03:05h | UTC

Dietary Inflammatory Potential and Risk of Cardiovascular Disease Among Men and Women in the U.S. – Journal of the American College of Cardiology

Editorial: Ideal Dietary Patterns and Foods to Prevent Cardiovascular Disease: Beware of Their Anti-Inflammatory Potential

Commentary: High Intake of Proinflammatory Foods Linked to CVD Risk – NEJM Journal Watch

 


[Abstract Only] Cohort study: Sodium–Glucose Cotransporter-2 Inhibitors and the risk for diabetic ketoacidosis

3 Nov, 2020 | 03:01h | UTC

Sodium–Glucose Cotransporter-2 Inhibitors and the Risk for Diabetic Ketoacidosis: A Multicenter Cohort Study – Annals of Internal Medicine

Commentarios: Can You Spot Euglycemic DKA From SGLT-2 Inhibitors? – Journal Feed AND Sodium glucose cotransporter-2 inhibitor use associated with increased risk of diabetic ketoacidosis – 2 Minute Medicine

 


Study provides new estimates of breast cancer risks associated with different hormone replacement therapy preparations

30 Oct, 2020 | 01:04h | UTC

Use of hormone replacement therapy and risk of breast cancer: nested case-control studies using the QResearch and CPRD databases – The BMJ

Commentaries: Study provides new estimates of breast cancer risks associated with HRT – University of Oxford AND New estimates of breast cancer risks associated with HRT – The BMJ AND HRT: Breast Ca Risk Tied to Hormone Type, Duration of Tx – Physician’s Weekly

 


Systematic review: PCSK9 monoclonal antibodies for the primary and secondary prevention of cardiovascular disease

29 Oct, 2020 | 08:57h | UTC

PCSK9 monoclonal antibodies for the primary and secondary prevention of cardiovascular disease – Cochrane Library

Summary: PCSK9 inhibitors for prevention of cardiovascular disease – Cochrane Library

 


[Abstract Only] Randomized trial: Effect of Finerenone on chronic kidney disease outcomes in Type 2 diabetes

25 Oct, 2020 | 23:34h | UTC

Effect of Finerenone on Chronic Kidney Disease Outcomes in Type 2 Diabetes – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Finerenone Linked to Reduced Cardiorenal Events for Chronic Kidney Disease – HCPLive

 

Commentary on Twitter (thread – click for more)

 


KDIGO 2020 Clinical practice guideline for diabetes management in chronic kidney disease

20 Oct, 2020 | 01:33h | UTC

KDIGO 2020 Clinical Practice Guideline for Diabetes Management in Chronic Kidney Disease – Kidney International

Executive summary: 2020 KDIGO Diabetes Management in CKD Guideline: evidence-based advances in monitoring and treatment – Kidney International

 

Commentary on Twitter

 


Life expectancy after bariatric surgery in the Swedish Obese Subjects Study

16 Oct, 2020 | 09:29h | UTC

Life Expectancy after Bariatric Surgery in the Swedish Obese Subjects Study – New England Journal of Medicine

Commentary: Higher average life expectancy after obesity surgery – University of Gothenburg

 

Commentary on Twitter

 


Review: Evaluation and treatment of patients with hypercortisolism

16 Oct, 2020 | 09:24h | UTC

Evaluation and Treatment of Patients With Hypercortisolism: A Review – JAMA Surgery

 


Meta-analysis: Nonpharmacologic interventions for reducing blood pressure in adults with prehypertension to established hypertension

14 Oct, 2020 | 09:20h | UTC

Nonpharmacologic Interventions for Reducing Blood Pressure in Adults With Prehypertension to Established Hypertension – Journal of the American Heart Association

 

Commentary on Twitter

 


Why people with diabetes are being hit so hard by Covid-19

8 Oct, 2020 | 09:04h | UTC

Why people with diabetes are being hit so hard by Covid-19 – STAT

 


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