Endocrinology
Bioethics | Should clinical guidelines incorporate cost pathways for persons with financial hardship?
28 Feb, 2021 | 20:54h | UTC
COVID-19 hospitalizations attributable to cardiometabolic conditions
26 Feb, 2021 | 08:40h | UTCCommentary: Study estimates two-thirds of COVID-19 hospitalizations due to four conditions – Tufts University
Commentary on Twitter
Our new research suggests 63% of US hospitalizations for COVID may have been prevented, due to less severe illness, if we had a metabolically healthy population. Biggest risk: obesity, responsible for 30% of excess hospitalizations. https://t.co/no8YhACf4E pic.twitter.com/4VPuHT0OPd
— Dariush Mozaffarian (@Dmozaffarian) February 25, 2021
Study: Unhealthy alcohol use common after bariatric surgery
26 Feb, 2021 | 08:14h | UTCCommentaries: Unhealthy Alcohol Use—A Common Iatrogenic Complication of Bariatric Surgery – JAMA Network Open AND Bariatric Surgery May Increase Risk of Unhealthy Alcohol Use – Psychiatric News Alert AND Bariatric Surgery Ups Risk of Alcohol Abuse – Physician’s Weekly
Commentary on Twitter
Our team’s analysis of VA bariatric surgery outcomes. Alcohol use increased 3–8 years after surgery. The benefits far outweigh the risks, but we need to support our patients long-term. @davearterburn @NeilFlochMD https://t.co/QpGHeRrI9l via @JAMANetworkOpen part of @JAMANetwork
— Luke Funk, MD, MPH (@lmfunk2) December 26, 2020
Series of n-of-1 trials show no difference in muscle symptoms in patients receiving placebo or statins
25 Feb, 2021 | 08:54h | UTCCommentary: Do statins cause muscle symptom side effects? – The BMJ Opinion AND Study: Muscle Symptoms Didn’t Differ Between Statin and Placebo Periods – NEJM Journal Watch
Related study: #AHA20 – In patients who had discontinued statins because of side effects, a N-of-1 trial of a statin, placebo, or no treatment found that side effects often attributed to statins were the same for those taking a placebo (study and commentaries)
RCT: Effect of high-dose subcutaneous Semaglutide vs. placebo in adults with overweight or obesity
25 Feb, 2021 | 08:52h | UTCRelated study: Once-weekly, high-dose semaglutide is effective for improving overweight or obesity among non-diabetic adults – New England Journal of Medicine (study and commentary)
Commentary on Twitter
In this RCT, once-weekly subcutaneous semaglutide used as an adjunct to intensive behavioral therapy & low-calorie diet led significantly greater weight loss vs placebo over 68 weeks among adults w #overweight or #obesity w/o #diabetes https://t.co/xFedvckUUj @PennMedicine #STEP3
— JAMA (@JAMA_current) February 24, 2021
Cohort study: High glycemic index diets are linked to increased risk of cardiovascular disease and death
25 Feb, 2021 | 08:49h | UTCCommentaries: Study finds diet high in poor quality carbohydrates increases heart disease and death – McMaster University AND High Glycemic Index Diets Linked to CVD and Mortality – TCTMD
SR: Metformin has modest efficacy for children with obesity
24 Feb, 2021 | 02:08h | UTCEfficacy and Safety of Metformin for Obesity: A Systematic Review – Pediatrics (link to abstract – $ for full-text)
Commentary: Metformin Underwhelms in Pediatric Obesity – Physician’s Weekly
Meta-analysis: Effect of food variety on intake of a meal
21 Feb, 2021 | 21:33h | UTC
RCT: Levothyroxine does not reduce the risk of developing depressive symptoms in older adults with subclinical hypothyroidism
18 Feb, 2021 | 02:46h | UTCRelated Studies: Association Between Levothyroxine Treatment and Thyroid-Related Symptoms Among Adults Aged 80 Years and Older With Subclinical Hypothyroidism – JAMA AND Thyroid Hormone Therapy for Older Adults with Subclinical Hypothyroidism – New England Journal of Medicine AND L-Thyroxine Therapy for Older Adults With Subclinical Hypothyroidism and Hypothyroid Symptoms: Secondary Analysis of a Randomized Trial – Annals of Internal Medicine
Guidelines (conflicting viewpoints): BMJ Guideline: Treatment of Subclinical Hypothyroidism AND Society for Endocrinology & British Thyroid Association issue statement against new treatment recommendations for subclinical hypothyroidism
Commentary on Twitter
Ancillary study of the TRUST RCT of levothyroxine therapy finds it does not reduce depression risk among older adults with subclinical hypothyroidism and shouldn't be prescribed for this purpose. #VisualAbstract https://t.co/yu3EChdkm1
— JAMA Network Open (@JAMANetworkOpen) February 10, 2021
SR: Concomitant use of levothyroxine and proton pump inhibitors causes a significant increase in TSH concentration
18 Feb, 2021 | 02:48h | UTC
Dieting may slow metabolism – but it doesn’t ruin it
18 Feb, 2021 | 02:44h | UTCDieting may slow metabolism – but it doesn’t ruin it – The Conversation
M-A: Intake of dietary fats and fatty acids and the incidence of type 2 diabetes
16 Feb, 2021 | 01:59h | UTC
RCT: Once-weekly, high-dose semaglutide is effective for improving overweight or obesity among non-diabetic adults
11 Feb, 2021 | 02:09h | UTCOnce-Weekly Semaglutide in Adults with Overweight or Obesity – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Semaglutide Plus Lifestyle Change Shown Effective for Obesity – NEJM Journal Watch
Commentary on Twitter
This double-blind study randomly assigned adults with obesity without diabetes to 68 weeks of once-weekly subcutaneous semaglutide or placebo, plus lifestyle intervention. Semaglutide therapy was associated with sustained, clinically relevant weight reduction.
— NEJM (@NEJM) February 10, 2021
Randomized, cross-over trial: Compared to Mediterranean diet, a Low-fat vegan diet is better at improving body weight, lipid concentrations, and insulin sensitivity
11 Feb, 2021 | 01:56h | UTC
Commentary on Twitter
36-week randomized cross-over trial:
💥Low-fat plant-based diet reduced body weight, fat mass, and visceral fat, increased insulin sensitivity, and improved blood lipids, compared with a Mediterranean diet.https://t.co/ROJX9WYcix
— Danielle Belardo, MD (@DBelardoMD) February 6, 2021
Red Yeast Rice for Hypercholesterolemia: JACC Focus Seminar
11 Feb, 2021 | 01:54h | UTC
Consensus statement: Cardiovascular health after menopause transition, pregnancy disorders, and other gynecologic conditions
10 Feb, 2021 | 01:25h | UTC
Commentary on Twitter
Cardiovascular health during menopause, pregnancy, and other gynaecologic conditions: European multidisciplinary consensus is out !https://t.co/fm6EBEbhVO.#cardiotwitter, @ESC_Journals, @escardio, #gynecology pic.twitter.com/WIekM50b07
— EHJ Editor-in-Chief (@ehj_ed) January 26, 2021
SR: Long‐term effects of weight‐reducing diets in people with hypertension
10 Feb, 2021 | 01:23h | UTCLong‐term effects of weight‐reducing diets in people with hypertension – Cochrane Library
Cohort study: Characteristics and outcomes of pregnant women with type 1 or type 2 diabetes
10 Feb, 2021 | 01:16h | UTCCharacteristics and outcomes of pregnant women with type 1 or type 2 diabetes: a 5-year national population-based cohort study – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)
Commentaries on Twitter
New #research online: Characteristics and outcomes of #pregnant women with type 1 or type 2 #diabetes: a 5-year national population-based cohort study https://t.co/qCOHToYDEa pic.twitter.com/ENAmhkhKvZ
— The Lancet Diabetes & Endocrinology (@TheLancetEndo) January 29, 2021
Important study from Prof Helen Murphy and colleagues in UK highlighting adverse outcomes in pregnancy with #Type2 and #type1diabetes. Glucose control and #obesity were main determinants. Big challenges ahead with increasing young-onset #type2
#maternalhealth @FIGOadvocacy https://t.co/X99hsN4KcK— Dr Ronald Ma (@DrRonaldMa1) January 31, 2021
Cohort study: Low risk of progression to diabetes among older adults with “prediabetes”
9 Feb, 2021 | 01:09h | UTCRisk of Progression to Diabetes Among Older Adults With Prediabetes – JAMA Internal Medicine (free for a limited period)
Commentaries: “Prediabetes” Diagnosis Less Useful in Older Patients – Johns Hopkins Bloomberg School of Public Health AND Prediabetes—A Risk Factor Twice Removed – JAMA Internal Medicine (free for a limited period) AND How many pre-diabetics go on to develop diabetes? – MedicalResearch.com
Author Interview: Risk of Progression to Diabetes Among Older Adults With Prediabetes
Related: The war on ‘prediabetes’ could be a boon for pharma—but is it good medicine? – Science
M-A: Effects of whole grain intake, compared with refined grain, on appetite and energy intake
9 Feb, 2021 | 00:50h | UTC
Commentary on Twitter
Effects of Whole Grain Intake, Compared with Refined Grain, on Appetite and Energy Intake: A Systematic Review and Meta-Analysis
"Whole grains modestly but significantly reduced
hunger…"https://t.co/wS1Vql4KHi@nutritionorg @jnutritionorg pic.twitter.com/5UWa28wkPW— Lukas Schwingshackl (@LSchwingshackl) February 8, 2021
SR/MA: Up to a third of patients may discontinue thyroid hormone replacement and remain euthyroid
7 Feb, 2021 | 21:02h | UTCClinical Outcomes After Discontinuation of Thyroid Hormone Replacement: A Systematic Review and Meta-Analysis – Thyroid (link to abstract – $ for full-text)
Commentary: A Third Discontinuing Levothyroxine Have Normal Thyroid Levels – Medscape (free registration required)
Commentaries on Twitter
Hard to believe that simply treating hypothyroidism may fit into “Things We Do For No Reason.”
But >1/3 of people on thyroid replacement stay euthyroid after stopping meds.
See article for results, predictors of euthyroidism, & de-escalation strategies.https://t.co/i1f04FnbPk pic.twitter.com/fGLAbjNo5B
— David A. Cohen (@DavidACohen_MD) January 21, 2021
(thread – click for more)
#endocation #endotwitter #endotips #endorules
Hypothyroidism🧠: Third of Patients Treated for
Hypothyroidism May Not Require Thyroid Hormones❗️https://t.co/iAZcwFB5Ul✅Hypothyroidism: 5% of population, age dependent
✅NHANES: 6.4% reported use of levothyroxine (LT4)1/
— Fady Hannah-Shmouni, MD FRCPC (@DrShmouni) January 14, 2021
Cohort study: Increased consumption of refined grains linked to higher risk of mortality and major cardiovascular disease events
5 Feb, 2021 | 01:30h | UTCCommentaries: Refined carbs like white bread, pasta, and pastries could increase risk of early death, a study found – Insider AND High intake of refined grains linked to higher risk of heart disease and death – The BMJ
Intermittent fasting may be effective weight loss strategy in patients with type 2 diabetes
4 Feb, 2021 | 01:00h | UTCOriginal Study: Metabolic Impact of Intermittent Fasting in Patients With Type 2 Diabetes Mellitus: A Systematic Review and Meta-analysis of Interventional Studies – The Journal of Clinical Endocrinology & Metabolism (link to abstract – $ for full-text)
AAP urges continuing obesity management
2 Feb, 2021 | 01:03h | UTCAAP urges continuing obesity management – Contemporary Pediatrics
Original Guideline: Obesity Management and Treatment During COVID-19 – American Academy of Pediatrics
Management of diabetes and hyperglycemia in the hospital
29 Jan, 2021 | 01:34h | UTCManagement of diabetes and hyperglycaemia in the hospital – The Lancet Diabetes & Endocrinology (free for a limited period)
Commentary on Twitter
New #Review online: Management of diabetes and hyperglycaemia in the hospital https://t.co/TmWLwFpYaw #diabetes #hospital #inpatient #critical #intensive #protocols #pharmacotherapy #technology #COVID19 pic.twitter.com/Uzg2enBz4a
— The Lancet Diabetes & Endocrinology (@TheLancetEndo) January 28, 2021