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GI Surgery – Esophagus

RCT: Effect of Camrelizumab vs. placebo added to chemotherapy on survival and progression-free survival in patients with advanced or metastatic esophageal squamous cell carcinoma.

15 Sep, 2021 | 08:51h | UTC

Effect of Camrelizumab vs Placebo Added to Chemotherapy on Survival and Progression-Free Survival in Patients With Advanced or Metastatic Esophageal Squamous Cell Carcinoma: The ESCORT-1st Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Immunotherapy for Advanced Esophageal Squamous Cell Carcinoma—Renewed Enthusiasm and a Lingering Challenge – JAMA Oncology (free for a limited period)

 

Commentary on Twitter

 


SAGES guidelines for the surgical treatment of gastroesophageal reflux.

21 Jul, 2021 | 10:34h | UTC

SAGES guidelines for the surgical treatment of gastroesophageal reflux (GERD) – Surgical Endoscopy

 


Global burden of cancer attributable to alcohol consumption – “Globally, an estimated 741.300, or 4·1% of all new cases of cancer in 2020 were attributable to alcohol consumption”.

14 Jul, 2021 | 11:07h | UTC

Global burden of cancer in 2020 attributable to alcohol consumption: a population-based study – The Lancet Oncology

News release: Alcohol consumption linked to more than 740,000 new cancer cases in 2020 – The Lancet

Commentaries: Alcohol caused 740,000 cancer cases globally last year – study – The Guardian AND Expert reaction to study of alcohol and cancer – Science Media Centre

 


RCT: Long-term efficacy of neoadjuvant chemoradiotherapy plus surgery for the treatment of locally advanced esophageal squamous cell carcinoma.

13 Jul, 2021 | 09:20h | UTC

Long-term Efficacy of Neoadjuvant Chemoradiotherapy Plus Surgery for the Treatment of Locally Advanced Esophageal Squamous Cell Carcinoma: The NEOCRTEC5010 Randomized Clinical Trial – JAMA Surgery

Commentary: Neoadjuvant chemoradiotherapy plus surgery increases overall survival of patients with advanced esophageal squamous cell carcinoma compared to surgery alone – 2 Minute Medicine

 

Commentary on Twitter

 


Ranitidine absolved? FDA study finds Ranitidine does not convert to carcinogen NDMA, regardless of diet.

12 Jul, 2021 | 01:36h | UTC

Effect of Oral Ranitidine on Urinary Excretion of N-Nitrosodimethylamine (NDMA): A Randomized Clinical Trial – JAMA

Editorial: Ranitidine and Risk of N-Nitrosodimethylamine (NDMA) Formation

Commentary: Ranitidine: FDA finds no evidence of elevated NDMA, regardless of diet

 

Commentaries on Twitter

 


RCT: Reduced-intensity chemotherapy among older and frail patients with advanced gastroesophageal cancer provides an improved patient experience with no significant detriment in cancer control.

20 May, 2021 | 08:18h | UTC

Efficacy of Reduced-Intensity Chemotherapy With Oxaliplatin and Capecitabine on Quality of Life and Cancer Control Among Older and Frail Patients With Advanced Gastroesophageal Cancer: The GO2 Phase 3 Randomized Clinical Trial – JAMA Oncology

Commentary: Lowering Chemo Dose Achieved Happier Patients, Good Outcomes in Elderly GI Cancer Patients – Physician’s Weekly

 

Commentary on Twitter

 


Randomized trial long-term results confirm the benefits of neoadjuvant chemoradiotherapy plus surgery for esophageal cancer

20 May, 2021 | 08:16h | UTC

Ten-Year Outcome of Neoadjuvant Chemoradiotherapy Plus Surgery for Esophageal Cancer: The Randomized Controlled CROSS Trial – Journal of Clinical Oncology

 

Commentaries on Twitter

 


RCT: Among patients with esophageal cancer, intrathoracic anastomosis after totally or hybrid minimally invasive esophagectomy resulted in lower anastomotic leakage rates and better outcomes when compared with cervical anastomosis.

18 May, 2021 | 07:21h | UTC

Intrathoracic vs Cervical Anastomosis After Totally or Hybrid Minimally Invasive Esophagectomy for Esophageal Cancer: A Randomized Clinical Trial – JAMA Surgery (free for a limited period)

Invited commentary: Does the Location Matter for the Anastomosis for Minimally Invasive Esophagectomy? (free for a limited period)

 

Commentary on Twitter

 


ACG Clinical Guideline: Upper Gastrointestinal and Ulcer Bleeding – RBC transfusion at a threshold of 7 g/dL; Erythromycin infusion is suggested before endoscopy; and endoscopy is suggested within 24 hours after presentation.

3 May, 2021 | 05:27h | UTC

ACG Clinical Guideline: Upper Gastrointestinal and Ulcer Bleeding – The American Journal of Gastroenterology

 


M-A: Treatment for bleeding esophageal varices in people with decompensated liver cirrhosis

12 Apr, 2021 | 00:39h | UTC

Treatment for bleeding oesophageal varices in people with decompensated liver cirrhosis: a network meta‐analysis – Cochrane Library

Summary: Treatment for bleeding from enlarged veins in the oesophagus (food pipe) in people with advanced scarring of the liver – Cochrane Library

Related Cochrane Reviews: M-A: Secondary prevention of variceal bleeding in adults with previous esophageal variceal bleeding due to decompensated liver cirrhosis AND Primary prevention of variceal bleeding in people with oesophageal varices due to liver cirrhosis: a network meta‐analysis – Cochrane Library

 


Meta-Analysis: Primary prevention of variceal bleeding in people with esophageal varices due to liver cirrhosis

8 Apr, 2021 | 08:45h | UTC

Primary prevention of variceal bleeding in people with oesophageal varices due to liver cirrhosis: a network meta‐analysis – Cochrane Library

Summary: Treatment to prevent first bleeding from dilated veins in the oesophagus resulting from advanced scarring of the liver – Cochrane Library

Related Cochrane Review: M-A: Secondary prevention of variceal bleeding in adults with previous esophageal variceal bleeding due to decompensated liver cirrhosis

 


M-A: Secondary prevention of variceal bleeding in adults with previous esophageal variceal bleeding due to decompensated liver cirrhosis

5 Apr, 2021 | 01:17h | UTC

Secondary prevention of variceal bleeding in adults with previous oesophageal variceal bleeding due to decompensated liver cirrhosis: a network meta‐analysis – Cochrane Library

Summary: Prevention of rebleeding from enlarged veins in the food pipe (oesophagus) resulting from advanced liver disease – Cochrane Library

 


RCT: No benefit from palliative radiotherapy after esophageal cancer stenting

18 Mar, 2021 | 08:52h | UTC

Palliative radiotherapy after oesophageal cancer stenting (ROCS): a multicentre, open-label, phase 3 randomised controlled trial – The Lancet Gastroenterology & Hepatology

 


Gastroesophageal reflux disease is linked with higher risks of larynx and esophageal cancers

24 Feb, 2021 | 02:00h | UTC

Gastroesophageal reflux disease is linked with higher risks of larynx and esophageal cancers – News Medical

Original study: Gastroesophageal reflux disease: A risk factor for laryngeal squamous cell carcinoma and esophageal squamous cell carcinoma in the NIH‐AARP Diet and Health Study cohort – Cancer

 


Randomized trial: Pneumatic dilation does not work for persistent dysphagia after antireflux surgery

19 Jan, 2021 | 01:13h | UTC

Pneumatic dilation for persistent dysphagia after antireflux surgery, a multicentre single-blind randomised sham-controlled clinical trial – Gut (link to abstract – $ for full-text)

 


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