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Clinical Pathology

Study | Uncovering the potential overuse of laboratory tests by combining cost, abnormal result proportion, and physician variation

11 Aug, 2023 | 15:34h | UTC

Data-driven approach to identifying potential laboratory overuse in general internal medicine (GIM) inpatients – BMJ Open Quality

 


Cohort Study | High-sensitivity troponin’s role in assessing MI and CV death risk in stable CAD patients

7 Aug, 2023 | 15:01h | UTC

High-Sensitivity Cardiac Troponin for Risk Assessment in Patients With Chronic Coronary Artery Disease – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentaries:

High-Sensitivity Troponin Assays May Stratify Risk in Chronic CAD – TCTMD

High-Sensitivity Cardiac Troponin for Risk Assessment in Chronic CAD – Journal of the American College of Cardiology

 

Commentary on Twitter

 


RCT | Limited antibiotic efficacy in children with sinusitis lacking nasopharyngeal pathogens

27 Jul, 2023 | 13:08h | UTC

Identifying Children Likely to Benefit From Antibiotics for Acute Sinusitis: A Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Acute Bacterial Sinusitis: Limitations of Test-Based Treatment – JAMA (free for a limited period)

News Release: Bacterial testing in kids with sinusitis could slash antibiotic use – University of Pittsburgh

Commentary: Trial suggests bacterial test could reduce antibiotics in kids with sinusitis – CIDRAP

 

Commentary on Twitter

 


New Cochrane handbook for systematic reviews of diagnostic test accuracy

25 Jul, 2023 | 14:02h | UTC

Cochrane Handbook for Systematic Reviews of Diagnostic Test Accuracy – Cochrane Library

Editorial: Evaluating medical tests: introducing the Cochrane Handbook for Systematic Reviews of Diagnostic Test Accuracy – Cochrane Library

News Release: Introducing the new Cochrane Handbook for Diagnostic Test Accuracy – Cochrane Library

 


Guideline | Laboratory analysis in the diagnosis and management of diabetes mellitus

21 Jul, 2023 | 13:50h | UTC

Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus – Diabetes Care

Executive Summary: Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus – Diabetes Care

 


RCT | Molecular screening for bacterial vaginosis does not significantly reduce preterm birth rates

21 Jul, 2023 | 13:31h | UTC

Effectiveness and Costs of Molecular Screening and Treatment for Bacterial Vaginosis to Prevent Preterm Birth: The AuTop Randomized Clinical Trial – JAMA Pediatrics

See also: Visual Abstract

 


Cohort study | Poor sensitivity of procalcitonin-on-admission for ruling out bloodstream infections in patients with suspected sepsis

18 Jul, 2023 | 13:39h | UTC

Reliability of Admission Procalcitonin Testing for Capturing Bacteremia Across the Sepsis Spectrum: Real-World Utilization and Performance Characteristics, 65 U.S. Hospitals, 2008–2017 – Critical Care Medicine (link to abstract – $ for full-text)

 


TTMV-HPV DNA testing | Promising diagnostic and surveillance tool for HPV-linked oropharyngeal cancer

17 Jul, 2023 | 13:25h | UTC

Performance of Liquid Biopsy for Diagnosis and Surveillance of Human Papillomavirus–Associated Oropharyngeal Cancer – JAMA Otolaryngology–Head & Neck Surgery (free for a limited period)

Invited Commentary: Circulating Human Papillomavirus Tumor DNA—Ready for Prime Time? –  – JAMA Otolaryngology–Head & Neck Surgery (free for a limited period)

 


Quality Improvement Study | Improved asymptomatic bacteriuria management by reduction of unnecessary urine culture requests

14 Jul, 2023 | 12:54h | UTC

A Statewide Quality Initiative to Reduce Unnecessary Antibiotic Treatment of Asymptomatic Bacteriuria – JAMA Internal Medicine

Related:

Diagnostic stewardship for urinary tract infection: A snapshot of the expert guidance – Cleveland Clinic Journal of Medicine

Study: Hospital Intervention Resulted in a 45% Reduction in the Urine Cultures Ordered

Optimal Urine Culture Diagnostic Stewardship Practice—Results from an Expert Modified-Delphi Procedure – Clinical Infectious Diseases

USPSTF Recommendation Statement: Screening for Asymptomatic Bacteriuria in Adults

Cohort Study: Antibiotic Treatment of Asymptomatic Bacteriuria in Hospitalized Patients is Common, and May be Associated with Longer Duration of Hospitalization

Inappropriate Management of Asymptomatic Patients With Positive Urine Cultures: A Systematic Review and Meta-analysis – Open Forum Infectious Diseases

IDSA Guideline for the Management of Asymptomatic Bacteriuria

 

Commentary on Twitter

 


Podcast | Wisely ordering autoantibodies

28 Jun, 2023 | 13:09h | UTC

#399 Wisely Ordering Autoantibodies – ACP IM2023 – The Curbsiders

 


Perspective | Early-stage lung cancer: using circulating tumor DNA to get personal

26 Jun, 2023 | 00:38h | UTC

Early-Stage Lung Cancer: Using Circulating Tumor DNA to Get Personal – Journal of Clinical Oncology

 


Review | Serial serum lipase testing after the initial diagnostic workup for inpatients with acute pancreatitis: what is the evidence?

21 Jun, 2023 | 13:27h | UTC

Serial serum lipase testing after the initial diagnostic workup for inpatients with acute pancreatitis: What is the evidence? – Cleveland Clinic Journal of Medicine

 


Review | Celiac disease: who should I test, and how?

19 Jun, 2023 | 13:54h | UTC

Celiac disease: Who should I test, and how? – Cleveland Clinic Journal of Medicine

 


M-A | Comparing non-invasive tests, histology for predicting non-alcoholic fatty liver outcomes

15 Jun, 2023 | 14:50h | UTC

Performance of non-invasive tests and histology for the prediction of clinical outcomes in patients with non-alcoholic fatty liver disease: an individual participant data meta-analysis – The Lancet Gastroenterology & Hepatology

 


Review | Candidate biomarkers in psychiatric disorders

15 Jun, 2023 | 14:52h | UTC

Candidate biomarkers in psychiatric disorders: state of the field – World Psychiatry

 


ESAIC focused guideline for the use of cardiac biomarkers in perioperative risk evaluation

5 Jun, 2023 | 13:37h | UTC

ESAIC focused guideline for the use of cardiac biomarkers in perioperative risk evaluation – European Journal of Anaesthesiology

 


SR | Biomarkers for myalgic encephalomyelitis/chronic fatigue syndrome

1 Jun, 2023 | 12:06h | UTC

Biomarkers for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): a systematic review – BMC Medicine

 


Cluster RCT | Point-of-care CRP testing cuts antibiotic prescriptions in respiratory illnesses in primary care

1 Jun, 2023 | 11:58h | UTC

Implementation of point-of-care testing of C-reactive protein concentrations to improve antibiotic targeting in respiratory illness in Vietnamese primary care: a pragmatic cluster-randomised controlled trial – The Lancet Infectious Diseases

Commentary: Use of CRP testing reduced antibiotics for respiratory infections, trial finds – CIDRAP

 


Cohort Study | NT‐proBNP and all-cause and cardiovascular mortality

31 May, 2023 | 13:59h | UTC

NT‐proBNP and All‐Cause and Cardiovascular Mortality in US Adults: A Prospective Cohort Study – Journal of the American Heart Association

 


Guideline | Use of non-invasive biomarkers for diagnosis of colorectal neoplasia

10 May, 2023 | 15:46h | UTC

Joint Asian Pacific Association of Gastroenterology (APAGE)–Asian Pacific Society of Digestive Endoscopy (APSDE) clinical practice guidelines on the use of non-invasive biomarkers for diagnosis of colorectal neoplasia – Gut

 


AACC Guidance document on the clinical use of procalcitonin

8 May, 2023 | 13:12h | UTC

AACC Guidance Document on the Clinical Use of Procalcitonin – The Journal of Applied Laboratory Medicine (free for a limited period)

 

Commentary on Twitter

 


Review | Transforming tuberculosis diagnosis

5 May, 2023 | 15:18h | UTC

Transforming tuberculosis diagnosis – Nature Microbiology (if the link is paywalled, try this one)

 

Commentary on Twitter

 


Diagnostic Stewardship | A continuum of antibiotic stewardship in combating antimicrobial resistance

4 May, 2023 | 13:58h | UTC

Diagnostic stewardship in infectious diseases: a continuum of antimicrobial stewardship in the fight against antimicrobial resistance – International Journal of Antimicrobial Agents

 


Scientific Statement | Role of natriuretic peptides in the diagnosis and management of heart failure

2 May, 2023 | 14:05h | UTC

Natriuretic Peptides: Role in the Diagnosis and Management of Heart Failure: A Scientific Statement From the Heart Failure Association of the European Society of Cardiology, Heart Failure Society of America and Japanese Heart Failure Society – European Journal of Heart Failure

 


RCT | Molecular point-of-care testing for gastroenteritis reduced isolation time but increased antibiotic use

28 Apr, 2023 | 13:15h | UTC

Clinical impact of syndromic molecular point-of-care testing for gastrointestinal pathogens in adults hospitalised with suspected gastroenteritis (GastroPOC): a pragmatic, open-label, randomised controlled trial – The Lancet Infectious Diseases

Commentary: Molecular testing in suspected infectious diarrhoea—the value of negative results – The Lancet Infectious Diseases

 


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