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Tropical Medicine

5 years later, researchers assess how children exposed to Zika are developing.

14 Jan, 2022 | 07:53h | UTC

5 years later, researchers assess how children exposed to Zika are developing – NPR

Related: Study: Neurodevelopmental Abnormalities in Children with in Utero Zika Virus Exposure Without Congenital Zika Syndrome

 


A cluster randomized trial in a yaws-endemic area of Papua New Guinea showed a reduction in the community prevalence of yaws with three rounds of mass administration of azithromycin at 6-month intervals compared with one round of mass administration of azithromycin followed by two rounds of targeted treatment.

12 Jan, 2022 | 08:44h | UTC

Trial of Three Rounds of Mass Azithromycin Administration for Yaws Eradication – New England Journal of Medicine (link to abstract – $ for full-text)

 

Commentary on Twitter

 


WHO Report: More malaria cases and deaths in 2020 linked to COVID-19 disruptions.

7 Dec, 2021 | 08:55h | UTC

News Release: More malaria cases and deaths in 2020 linked to COVID-19 disruptions – World Health Organization

Report: World Malaria Report 2021 – World Health Organization

Commentaries:

More people died of malaria in 2020 than in 2019. Here’s why – NPR

Malaria kills 180,000 more people annually than previously thought, says WHO – The Guardian

 

Commentary on Twitter (thread – click for more)

 


Review: Prevention of emerging infections in children.

23 Nov, 2021 | 08:17h | UTC

Prevention of Emerging Infections in Children – Pediatric Clinics of North America

 


#AHA21 – RCT: Among children and adolescents who had screening echocardiograms and were identified as having latent rheumatic heart disease, secondary antibiotic prophylaxis with penicillin G benzathine for 2 years was associated with reduced echocardiographic progression (0.8 vs. 8.2% in the control group).

14 Nov, 2021 | 20:03h | UTC

Secondary Antibiotic Prophylaxis for Latent Rheumatic Heart Disease – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries:

Penicillin significantly reduces rheumatic heart disease progression in children – Murdoch Children’s Research Institute

Penicillin slows devastating impacts of rheumatic heart disease in children from Uganda – Children’s National Hospital

Secondary Antibiotic Prophylaxis for Latent Rheumatic Heart Disease – American College of Cardiology

 

Commentaries on Twitter

 


Systematic Review: Administration of antimalarial drugs to whole populations for reducing malaria.

7 Oct, 2021 | 10:36h | UTC

Administration of antimalarial drugs to whole populations for reducing malaria – Cochrane Library

Original study: Mass drug administration for malaria – Cochrane Library

 

Commentary on Twitter

 


WHO approves first ever malaria vaccine for children at risk.

7 Oct, 2021 | 10:40h | UTC

WHO recommends groundbreaking malaria vaccine for children at risk – World Health Organization

Commentaries:

WHO Approves First Ever Malaria Vaccine – Health Policy Watch

A historic day for malaria – reaction to WHO decision on the RTS,S vaccine – London School of Hygiene & Tropical Medicine

In major decision, WHO recommends broad rollout of world’s first malaria vaccine – STAT

Why the WHO approval of the first malaria vaccine is a big deal – Vox

WHO greenlights the world’s first malaria vaccine — but it’s not a perfect shot – NPR

The World Health Organization Just Endorsed The World’s First Malaria Vaccine – TIME

WHO Backs Widespread Use Of First Malaria Vaccine – Forbes

World’s 1st malaria vaccine recommended by WHO – LiveScience

 

Commentaries on Twitter

(thread – click for more)

 


Drug-resistant malaria is gaining a foothold in Africa – “Analyses of patient blood samples suggest artemisinin effectiveness is slipping”.

28 Sep, 2021 | 08:49h | UTC

Drug-resistant malaria is gaining a foothold in Africa – Science

 

Commentary on Twitter

 


How COVID is derailing the fight against HIV, TB and malaria.

15 Sep, 2021 | 09:01h | UTC

How COVID is derailing the fight against HIV, TB and malaria – Nature

Related:

How COVID hurt the fight against other dangerous diseases

World TB Day | Report: COVID-19 Eliminates Twelve Years of Progress Against Tuberculosis

WHO: Benefits of continuing to provide life-saving HIV services outweigh the risk of COVID-19 transmission by 100 to 1

 


An update on prevention of malaria in travelers.

15 Sep, 2021 | 08:39h | UTC

An update on prevention of malaria in travelers – Therapeutic Advances in Infectious Disease

Related: CDC Yellow Book

 


RCT: Severe malaria among young African children dramatically reduced through seasonal vaccination and preventative drug combination.

1 Sep, 2021 | 09:02h | UTC

News release: Severe malaria among young African children dramatically reduced through seasonal vaccination and preventative drug combination – London School of Hygiene & Tropical Medicine

Original article: Seasonal Malaria Vaccination with or without Seasonal Malaria Chemoprevention – New England Journal of Medicine

Commentary: Malaria trial shows ‘striking’ 70% reduction in severe illness in children – The Guardian

Related: Malaria vaccine becomes first to achieve WHO-specified 75% efficacy goal

 


Cluster RCT: Vaccination of children against typhoid fever with a Vi-tetanus toxoid conjugate vaccine in urban Bangladesh conferred 85% total protection.

11 Aug, 2021 | 08:28h | UTC

Protection by vaccination of children against typhoid fever with a Vi-tetanus toxoid conjugate vaccine in urban Bangladesh: a cluster-randomised trial – The Lancet

Invited commentary: Salmonella Typhi Vi polysaccharide conjugate vaccine protects infants and children against typhoid fever – The Lancet

 


Diagnosis and clinical management of hepatosplenic schistosomiasis: A scoping review of the literature.

15 Jul, 2021 | 09:02h | UTC

Diagnosis and clinical management of hepatosplenic schistosomiasis: A scoping review of the literature – PLOS Neglected Tropical Diseases

 


CDC advisory panel backs use of dengue vaccine in high-risk areas, despite delivery challenges.

25 Jun, 2021 | 10:13h | UTC

CDC advisory panel backs use of dengue vaccine in high-risk areas, despite delivery challenges – STAT

 


WHO issues new guidance for research on genetically modified mosquitoes to fight malaria and other vector-borne diseases.

10 Jun, 2021 | 09:38h | UTC

News release: WHO issues new guidance for research on genetically modified mosquitoes to fight malaria and other vector-borne diseases – World Health Organization

Guideline: The guidance framework for testing genetically modified mosquitoes – World Health Organization

 


Cluster-randomized trial: Wolbachia-infected Aedes aegypti (less susceptible than wild-type A. aegypti to dengue virus infection) deployments reduced the incidence of symptomatic dengue and resulted in fewer hospitalizations.

10 Jun, 2021 | 09:40h | UTC

Efficacy of Wolbachia-Infected Mosquito Deployments for the Control of Dengue – New England Journal of Medicine

Commentary: ‘Miraculous’ mosquito hack cuts dengue by 77% – BBC

Video Abstract: Efficacy of Wolbachia-infected Mosquito Deployments for the Control of Dengue

 


Malaria vaccine becomes first to achieve WHO-specified 75% efficacy goal

25 Apr, 2021 | 21:17h | UTC

News release: Malaria vaccine becomes first to achieve WHO-specified 75% efficacy goal – University of Oxford

Original study (preprint): High Efficacy of a Low Dose Candidate Malaria Vaccine, R21 in 1 Adjuvant Matrix-M™, with Seasonal Administration to Children in Burkina Faso – The Lancet

Commentaries: Malaria vaccine hailed as potential breakthrough – BBC AND Oxford Malaria vaccine proves highly effective in Burkina Faso trial – The Guardian

 

Commentary on Twitter (thread – click for more)

 


Ahead of World Malaria Day, WHO launches effort to stamp out malaria in 25 more countries by 2025

22 Apr, 2021 | 08:23h | UTC

World Malaria Day: WHO launches effort to stamp out malaria in 25 more countries by 2025 – World Health Organization

Report: Zeroing in on malaria elimination: Final report of the E-2020 initiative – World Health Organization

 


How COVID hurt the fight against other dangerous diseases

22 Apr, 2021 | 08:35h | UTC

How COVID hurt the fight against other dangerous diseases – Nature

Related: World TB Day | Report: COVID-19 Eliminates Twelve Years of Progress Against Tuberculosis AND WHO: Benefits of continuing to provide life-saving HIV services outweigh the risk of COVID-19 transmission by 100 to 1

 


RCT: New shorter regimens of benznidazole monotherapy and in combination with fosravuconazole for treatment of Chagas disease

8 Apr, 2021 | 08:47h | UTC

New regimens of benznidazole monotherapy and in combination with fosravuconazole for treatment of Chagas disease (BENDITA): a phase 2, double-blind, randomised trial – The Lancet Infectious Diseases

Commentary: Chagas disease: Shorter treatment just as effective as longer one, according to study in Bolivia published by The Lancet – Drugs for Neglected Diseases Initiative

 


Ebola Virus Transmission Initiated by Relapse of Systemic Ebola Virus Disease

5 Apr, 2021 | 01:05h | UTC

Ebola Virus Transmission Initiated by Relapse of Systemic Ebola Virus Disease – New England Journal of Medicine

Related: Resurgence of Ebola Virus disease in Guinea linked to a survivor with virus persistence in seminal fluid for more than 500 days

 

Commentary on Twitter

 


Diagnosis and clinical management of hepatosplenic schistosomiasis: A scoping review of the literature

31 Mar, 2021 | 03:01h | UTC

Diagnosis and clinical management of hepatosplenic schistosomiasis: A scoping review of the literature – PLOS Neglected Tropical Diseases

 


Resurgence of Ebola Virus disease in Guinea linked to a survivor with virus persistence in seminal fluid for more than 500 days

14 Mar, 2021 | 20:15h | UTC

Resurgence of Ebola Virus Disease in Guinea Linked to a Survivor With Virus Persistence in Seminal Fluid for More Than 500 Days – Clinical Infectious Diseases

Commentaries: Bombshell analysis traces new Ebola outbreak to survivor of West Africa crisis – STAT AND New Ebola outbreak likely sparked by a person infected 5 years ago – Science AND Ebola survivors can pass on the virus: we’re trying to understand what role sex plays – The Conversation AND The latest Ebola outbreak may have started with someone infected years ago – Science News

 


WHO Guidance: Management of people affected by lymphatic filariasis

7 Mar, 2021 | 19:26h | UTC

News release: WHO publishes materials that aim to provide high-quality care to people affected by lymphatic filariasis – World Health Organization

Guidance: Lymphatic filariasis: managing morbidity and preventing disability: an aide-mémoire for national programme managers, 2nd ed. – World Health Organization

 


Systematic review: Atovaquone‐proguanil for treating uncomplicated Plasmodium falciparum malaria

5 Mar, 2021 | 08:13h | UTC

Atovaquone‐proguanil for treating uncomplicated Plasmodium falciparum malaria – Cochrane Library

Summary: What are the benefits and risks of atovaquone-proguanil for treating uncomplicated malaria caused by the parasite? – Cochrane Library

 


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