Tropical Medicine
5 years later, researchers assess how children exposed to Zika are developing.
14 Jan, 2022 | 07:53h | UTC5 years later, researchers assess how children exposed to Zika are developing – NPR
A cluster randomized trial in a yaws-endemic area of Papua New Guinea showed a reduction in the community prevalence of yaws with three rounds of mass administration of azithromycin at 6-month intervals compared with one round of mass administration of azithromycin followed by two rounds of targeted treatment.
12 Jan, 2022 | 08:44h | UTCTrial of Three Rounds of Mass Azithromycin Administration for Yaws Eradication – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary on Twitter
Data from a community-based trial in Papua New Guinea suggest that more than one round of mass drug administration should be considered as part of the strategy for yaws eradication. https://t.co/7Cfuz16CUa pic.twitter.com/pVRyefOlTb
— NEJM (@NEJM) January 6, 2022
WHO Report: More malaria cases and deaths in 2020 linked to COVID-19 disruptions.
7 Dec, 2021 | 08:55h | UTCNews Release: More malaria cases and deaths in 2020 linked to COVID-19 disruptions – World Health Organization
Report: World Malaria Report 2021 – World Health Organization
Commentaries:
More people died of malaria in 2020 than in 2019. Here’s why – NPR
Malaria kills 180,000 more people annually than previously thought, says WHO – The Guardian
Commentary on Twitter (thread – click for more)
#COVID19 pandemic has disrupted #malaria services, leading to a marked increase in cases and deaths: 14 million more cases in 2020 compared to 2019, and 69,000 more deaths – new report.
➡️https://t.co/M9sNo2Pn4u #EndMalaria pic.twitter.com/g6MKFVpQKf— World Health Organization (WHO) (@WHO) December 6, 2021
Review: Prevention of emerging infections in children.
23 Nov, 2021 | 08:17h | UTCPrevention of Emerging Infections in Children – Pediatric Clinics of North America
#AHA21 – RCT: Among children and adolescents who had screening echocardiograms and were identified as having latent rheumatic heart disease, secondary antibiotic prophylaxis with penicillin G benzathine for 2 years was associated with reduced echocardiographic progression (0.8 vs. 8.2% in the control group).
14 Nov, 2021 | 20:03h | UTCSecondary Antibiotic Prophylaxis for Latent Rheumatic Heart Disease – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries:
Secondary Antibiotic Prophylaxis for Latent Rheumatic Heart Disease – American College of Cardiology
Commentaries on Twitter
One of most important studies ever Rheumatic Heart Disease @NEJM https://t.co/U8FuNHLqCJ RCT evidence 2ry prophylaxis reduces progression latent RhD pic.twitter.com/UycTElr7QM
— Michael Marks (@dr_michaelmarks) November 13, 2021
Penicillin slowed the devastating impact of rheumatic heart disease among children in Uganda. Findings of a large-scale, randomized controlled trial were completed in Uganda. Group A strep underlies rheumatic heart disease. New England Journal of Medicine https://t.co/1PKFJ12FvC
— delthia ricks 🔬 (@DelthiaRicks) November 13, 2021
Systematic Review: Administration of antimalarial drugs to whole populations for reducing malaria.
7 Oct, 2021 | 10:36h | UTCAdministration of antimalarial drugs to whole populations for reducing malaria – Cochrane Library
Original study: Mass drug administration for malaria – Cochrane Library
Commentary on Twitter
Administration of #antimalarial drugs to whole populations for reducing #malaria – https://t.co/4Q4vGKwmgU – Updated #OpenAccess @Cochrane_IDG review includes 13 studies and gives implications for practice & future research. pic.twitter.com/EMB2Tihs81
— Cochrane UK (@CochraneUK) October 3, 2021
WHO approves first ever malaria vaccine for children at risk.
7 Oct, 2021 | 10:40h | UTCWHO recommends groundbreaking malaria vaccine for children at risk – World Health Organization
Commentaries:
WHO Approves First Ever Malaria Vaccine – Health Policy Watch
In major decision, WHO recommends broad rollout of world’s first malaria vaccine – STAT
Why the WHO approval of the first malaria vaccine is a big deal – Vox
WHO greenlights the world’s first malaria vaccine — but it’s not a perfect shot – NPR
The World Health Organization Just Endorsed The World’s First Malaria Vaccine – TIME
WHO Backs Widespread Use Of First Malaria Vaccine – Forbes
World’s 1st malaria vaccine recommended by WHO – LiveScience
Commentaries on Twitter
I started my career as a #malaria researcher, and I longed for the day that we would have an effective vaccine against this ancient and terrible disease. Today is that day: @WHO is recommending the broad use of the world’s first malaria vaccine. #EndMalaria https://t.co/Oh1O155tYj
— Tedros Adhanom Ghebreyesus (@DrTedros) October 6, 2021
(thread – click for more)
A child dies from #malaria every two minutes.
One death is one too many.🚨 Today, WHO recommends RTS,S, a groundbreaking malaria vaccine, to reduce child illness & deaths in areas with moderate and high malaria transmission https://t.co/xSk58nTIV1#VaccinesWork pic.twitter.com/mSECLtRhQs
— World Health Organization (WHO) (@WHO) October 6, 2021
Drug-resistant malaria is gaining a foothold in Africa – “Analyses of patient blood samples suggest artemisinin effectiveness is slipping”.
28 Sep, 2021 | 08:49h | UTCDrug-resistant malaria is gaining a foothold in Africa – Science
Commentary on Twitter
Drug-evading parasites appeared in Southeast Asia in the early 2000s, eventually leading to failures of key therapies.
But the stakes are higher for Africa, home to 94% of both malaria cases and deaths worldwide in 2019. https://t.co/ILamXKP3yh
— Global Health NOW (@ghn_news) September 27, 2021
How COVID is derailing the fight against HIV, TB and malaria.
15 Sep, 2021 | 09:01h | UTCHow COVID is derailing the fight against HIV, TB and malaria – Nature
Related:
How COVID hurt the fight against other dangerous diseases
World TB Day | Report: COVID-19 Eliminates Twelve Years of Progress Against Tuberculosis
An update on prevention of malaria in travelers.
15 Sep, 2021 | 08:39h | UTCAn update on prevention of malaria in travelers – Therapeutic Advances in Infectious Disease
Related: CDC Yellow Book
RCT: Severe malaria among young African children dramatically reduced through seasonal vaccination and preventative drug combination.
1 Sep, 2021 | 09:02h | UTCOriginal article: Seasonal Malaria Vaccination with or without Seasonal Malaria Chemoprevention – New England Journal of Medicine
Commentary: Malaria trial shows ‘striking’ 70% reduction in severe illness in children – The Guardian
Related: Malaria vaccine becomes first to achieve WHO-specified 75% efficacy goal
Cluster RCT: Vaccination of children against typhoid fever with a Vi-tetanus toxoid conjugate vaccine in urban Bangladesh conferred 85% total protection.
11 Aug, 2021 | 08:28h | UTCInvited commentary: Salmonella Typhi Vi polysaccharide conjugate vaccine protects infants and children against typhoid fever – The Lancet
Diagnosis and clinical management of hepatosplenic schistosomiasis: A scoping review of the literature.
15 Jul, 2021 | 09:02h | UTC
CDC advisory panel backs use of dengue vaccine in high-risk areas, despite delivery challenges.
25 Jun, 2021 | 10:13h | UTC
WHO issues new guidance for research on genetically modified mosquitoes to fight malaria and other vector-borne diseases.
10 Jun, 2021 | 09:38h | UTCGuideline: The guidance framework for testing genetically modified mosquitoes – World Health Organization
Cluster-randomized trial: Wolbachia-infected Aedes aegypti (less susceptible than wild-type A. aegypti to dengue virus infection) deployments reduced the incidence of symptomatic dengue and resulted in fewer hospitalizations.
10 Jun, 2021 | 09:40h | UTCCommentary: ‘Miraculous’ mosquito hack cuts dengue by 77% – BBC
Video Abstract: Efficacy of Wolbachia-infected Mosquito Deployments for the Control of Dengue
Malaria vaccine becomes first to achieve WHO-specified 75% efficacy goal
25 Apr, 2021 | 21:17h | UTCNews release: Malaria vaccine becomes first to achieve WHO-specified 75% efficacy goal – University of Oxford
Original study (preprint): High Efficacy of a Low Dose Candidate Malaria Vaccine, R21 in 1 Adjuvant Matrix-M™, with Seasonal Administration to Children in Burkina Faso – The Lancet
Commentaries: Malaria vaccine hailed as potential breakthrough – BBC AND Oxford Malaria vaccine proves highly effective in Burkina Faso trial – The Guardian
Commentary on Twitter (thread – click for more)
💡AMAZING—First high >75% efficacy vaccine for a disease with 229 million cases & 409,000 deaths worldwide in 2019 —#Malaria!
Created by Oxford, produced by Serum Institute of India, & supporting adjuvant by Novavax, SII expects to make 200 mil doses a year!
Science! #vaccine pic.twitter.com/gnPMvXxww6
— Eric Feigl-Ding (@DrEricDing) April 23, 2021
Ahead of World Malaria Day, WHO launches effort to stamp out malaria in 25 more countries by 2025
22 Apr, 2021 | 08:23h | UTCReport: Zeroing in on malaria elimination: Final report of the E-2020 initiative – World Health Organization
How COVID hurt the fight against other dangerous diseases
22 Apr, 2021 | 08:35h | UTCHow COVID hurt the fight against other dangerous diseases – Nature
Related: World TB Day | Report: COVID-19 Eliminates Twelve Years of Progress Against Tuberculosis AND WHO: Benefits of continuing to provide life-saving HIV services outweigh the risk of COVID-19 transmission by 100 to 1
RCT: New shorter regimens of benznidazole monotherapy and in combination with fosravuconazole for treatment of Chagas disease
8 Apr, 2021 | 08:47h | UTC
Ebola Virus Transmission Initiated by Relapse of Systemic Ebola Virus Disease
5 Apr, 2021 | 01:05h | UTC
Commentary on Twitter
In this report from the Democratic Republic of Congo, Ebola virus disease developed in a young man, and he recovered after treatment with a monoclonal antibody.
6 months later, EVD recrudesced, and he transmitted the virus to others & died from EVD @NEJM https://t.co/kJSBNdN5bC pic.twitter.com/jDnnGMLmOG— Antibiotic Steward🆔🦠Bassam Ghanem (@ABsteward) March 31, 2021
Diagnosis and clinical management of hepatosplenic schistosomiasis: A scoping review of the literature
31 Mar, 2021 | 03:01h | UTC
Resurgence of Ebola Virus disease in Guinea linked to a survivor with virus persistence in seminal fluid for more than 500 days
14 Mar, 2021 | 20:15h | UTCCommentaries: Bombshell analysis traces new Ebola outbreak to survivor of West Africa crisis – STAT AND New Ebola outbreak likely sparked by a person infected 5 years ago – Science AND Ebola survivors can pass on the virus: we’re trying to understand what role sex plays – The Conversation AND The latest Ebola outbreak may have started with someone infected years ago – Science News
WHO Guidance: Management of people affected by lymphatic filariasis
7 Mar, 2021 | 19:26h | UTC
Systematic review: Atovaquone‐proguanil for treating uncomplicated Plasmodium falciparum malaria
5 Mar, 2021 | 08:13h | UTCAtovaquone‐proguanil for treating uncomplicated Plasmodium falciparum malaria – Cochrane Library