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Critical Care & Emergencies (All Articles)

RCT: Baclofen reduces agitation in patients with unhealthy alcohol use receiving mechanical ventilation, but results in a longer time receiving mechanical ventilation and more extended ICU stay

28 Feb, 2021 | 21:09h | UTC

Effect of High-Dose Baclofen on Agitation-Related Events Among Patients With Unhealthy Alcohol Use Receiving Mechanical Ventilation: A Randomized Clinical Trial – JAMA

Editorial: Baclofen to Prevent Agitation Caused by Alcohol Withdrawal in the ICU

Video presentation: Effect of Baclofen on Agitation-Related Events Among Mechanically Ventilated Patients With Alcohol Use Disorder

 

Commentary on Twitter

 

RCT: Balanced opioid-free anesthesia with Dexmedetomidine resulted in a greater incidence of serious adverse events, especially hypoxemia and bradycardia

28 Feb, 2021 | 21:03h | UTC

Balanced Opioid-free Anesthesia with Dexmedetomidine versus Balanced Anesthesia with Remifentanil for Major or Intermediate Noncardiac Surgery: The Postoperative and Opioid-free Anesthesia (POFA) Randomized Clinical Trial – Anesthesiology

 

RCT: An intensive blood pressure lowering strategy after successful endovascular therapy in acute ischemic stroke did not reduce radiographic intraparenchymal hemorrhage rates

28 Feb, 2021 | 20:59h | UTC

Safety and efficacy of intensive blood pressure lowering after successful endovascular therapy in acute ischaemic stroke (BP-TARGET): a multicentre, open-label, randomised controlled trial – The Lancet Neurology (link to abstract – $ for full-text)

 

M-A: Risk predictors of progression to severe disease during the febrile phase of dengue

28 Feb, 2021 | 20:57h | UTC

Risk predictors of progression to severe disease during the febrile phase of dengue: a systematic review and meta-analysis – The Lancet Infectious Diseases

 

PRO-CON Debate: Are Carbapenems necessary for all infections caused by ceftriaxone-resistant Enterobacterales?

28 Feb, 2021 | 20:43h | UTC

PRO: Carbapenems should be used for ALL infections caused by ceftriaxone-resistant Enterobacterales – JAC-Antimicrobial Resistance

CON: Carbapenems are NOT necessary for all infections caused by ceftriaxone-resistant Enterobacterales – JAC-Antimicrobial Resistance

Editorial: Navigating treatment approaches for presumed ESBL-producing infections

 

Commentary on Twitter (thread – click for more)

 

Conflicting results from 2 randomized trials testing Tocilizumab for Covid-19

26 Feb, 2021 | 08:48h | UTC

Study 1: Tocilizumab in Hospitalized Patients with Severe Covid-19 Pneumonia – New England Journal of Medicine

Study 2: Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19 – New England Journal of Medicine

Editorial: Interleukin-6 Receptor Inhibition in Covid-19 — Cooling the Inflammatory Soup – New England Journal of Medicine

 

Commentary on Twitter

 

Cohort study: A single conventional Troponin combined with HEART score may be as good as serial measurements for safe discharge of patients with chest pain in the ED

26 Feb, 2021 | 08:32h | UTC

Single vs Serial Measurements of Cardiac Troponin Level in the Evaluation of Patients in the Emergency Department With Suspected Acute Myocardial Infarction – JAMA Network Open

Editorial: Troponin Testing in the Emergency Department—When 2 Become 1

Commentary: Single Troponin Test May Be Enough for Safe Discharge of Chest Pain Patients – TCTMD

 

RCT: Dimenhydrinate and metoclopramide equally effective in the treatment of nausea due to vertigo

26 Feb, 2021 | 08:12h | UTC

Comparison of efficacy dimenhydrinate and metoclopramide in the treatment of nausea due to vertigo; a randomized study – The American Journal of Emergency Medicine (link to abstract – $ for full-text)

 

Position Paper: Management of drug-induced liver injury

25 Feb, 2021 | 08:27h | UTC

Drug-induced liver injury: A management position paper from the Latin American Association for Study of the liver – Annals of Hepatology

 

ICU-based renal replacement therapy

25 Feb, 2021 | 08:23h | UTC

ICU-Based Renal Replacement Therapy – Critical Care Medicine

 

Commentary on Twitter

 

Sepsis treatment: Another trial shows no benefit from the combination of Vitamin C, Thiamine, and Hydrocortisone

24 Feb, 2021 | 02:25h | UTC

Effect of Vitamin C, Thiamine, and Hydrocortisone on Ventilator- and Vasopressor-Free Days in Patients With Sepsis: The VICTAS Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Hydrocortisone, Vitamin C, and Thiamine for Treatment of Sepsis: Making Evidence Matter

Related: The VITAMINS Randomized Clinical Trial: Vitamin C, Hydrocortisone, and Thiamine Not beneficial for Patients with Sepsis (study and commentaries)

 

Commentary on Twitter

 

Diverticulitis: Observational study in outpatients suggests amoxicillin-clavulanate is a safe and effective option compared with metronidazole-fluoroquinolone

24 Feb, 2021 | 02:16h | UTC

Comparative Effectiveness and Harms of Antibiotics for Outpatient Diverticulitis: Two Nationwide Cohort Studies – Annals of Internal Medicine

Commentaries: Amoxicillin-clavulanate safe and effective compared with metronidazole-with-fluoroquinolone for diverticulitis – American College of Physicians AND Study supports fluoroquinolone-sparing treatment for diverticulitis – CIDRAP

 

How the COVID-19 pandemic will change the future of critical care

24 Feb, 2021 | 02:49h | UTC

How the COVID-19 pandemic will change the future of critical care – Intensive Care Medicine

 

Commentary on Twitter

 

M-A: The diagnostic accuracy of noninvasive methods to measure the intracranial pressure

23 Feb, 2021 | 01:14h | UTC

The Diagnostic Accuracy of Noninvasive Methods to Measure the Intracranial Pressure: A Systematic Review and Meta-analysis – Anesthesia & Analgesia

 

RCT: Topical intranasal tranexamic acid does not reduce the need for nasal packing in epistaxis

21 Feb, 2021 | 22:02h | UTC

The Use of Tranexamic Acid to Reduce the Need for Nasal Packing in Epistaxis (NoPAC): Randomized Controlled Trial – Annals of Emergency Medicine (link to abstract – $ for full-text)

 

Commentary on Twitter

 

FDA issues alert on ‘limitations’ of pulse oximeters, without explicit mention of racial bias

23 Feb, 2021 | 02:03h | UTC

FDA issues alert on ‘limitations’ of pulse oximeters, without explicit mention of racial bias – STAT

FDA Safety Alert: Pulse Oximeter Accuracy and Limitations: FDA Safety Communication – U.S. Food & Drug Administration

Related: “Racial Bias in Pulse Oximetry Measurement”. In two large cohorts, Black patients had nearly three times the frequency of occult hypoxemia that was not detected by pulse oximetry as White patients – New England Journal of Medicine (study and commentaries)

 

Editorial: Prophylactic anticoagulation for patients in hospital with covid-19

23 Feb, 2021 | 01:59h | UTC

Prophylactic anticoagulation for patients in hospital with covid-19 – The BMJ

Related: Full-dose Heparin best for moderate COVID-19 regardless of D-dimer — Data released from ACTIV-4a, ATTACC, and REMAP-CAP trials AND Cohort study: Early initiation of prophylactic anticoagulation linked to reduced mortality in patients admitted to hospital with Covid-19

 

Expert consensus of data elements for collection for enhanced recovery after cardiac surgery

21 Feb, 2021 | 21:53h | UTC

Expert Consensus of Data Elements for Collection for Enhanced Recovery After Cardiac Surgery – World Journal of Surgery

Related: Enhanced Recovery After Surgery (ERAS) Guidelines for Perioperative Care in Cardiac Surgery (guideline and commentary) AND Enhanced Recovery After Cardiac Surgery (ERAS Cardiac) Recommendations: An Important First Step—But There Is Much Work to Be Done – Cardiothoracic and Vascular Anesthesia (free)

See also: Enhanced Recovery After Surgery (ERAS) Society Guidelines

 

Commentary on Twitter

 

RCT: Five oral analgesics (including opioids) are equally effective for the treatment of acute musculoskeletal extremity pain in the emergency department

21 Feb, 2021 | 21:39h | UTC

A Randomized Trial Comparing the Efficacy of Five Oral Analgesics for Treatment of Acute Musculoskeletal Extremity Pain in the Emergency Department – Annals of Emergency Medicine (link to abstract – $ for full-text)

 

Commentary on Twitter

 

Intensive care management of patients with COVID-19: a practical approach

21 Feb, 2021 | 22:34h | UTC

Intensive care management of patients with COVID-19: a practical approach – Intensive Care Management

Related Guideline: Surviving Sepsis Campaign Guidelines on the Management of Adults With Coronavirus Disease 2019 (COVID-19) in the ICU: First Update AND Infographic

 

Current use of inotropes in circulatory shock

21 Feb, 2021 | 21:34h | UTC

Current use of inotropes in circulatory shock – Annals of Intensive Care

 

COVID‐19 convalescent plasma: Interim recommendations from the AABB

19 Feb, 2021 | 02:56h | UTC

COVID‐19 convalescent plasma: interim recommendations from the AABB – Transfusion

News release: AABB panel issues interim recommendations for Covid-19 convalescent plasma use

 

SOFA score is not accurate enough for mortality prediction in severely ill patients with COVID-19 pneumonia

19 Feb, 2021 | 02:44h | UTC

Determining the Probable Mortality of Patients With COVID-19 Pneumonia Requiring Mechanical Ventilation – JAMA

 

Commentary on Twitter

 

Review: Oxygen administration for patients with ARDS

19 Feb, 2021 | 02:24h | UTC

Oxygen administration for patients with ARDS – Journal of Intensive Care

 

RCT: Vitamin D3 does not improve outcomes in hospitalized patients with moderate to severe COVID-19

18 Feb, 2021 | 03:20h | UTC

Effect of a Single High Dose of Vitamin D3 on Hospital Length of Stay in Patients With Moderate to Severe COVID-19: A Randomized Clinical Trial – JAMA

Editorial: Vitamin D3 to Treat COVID-19: Different Disease, Same Answer

 

 

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