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Critical Care & Emergencies

Observational Study: Many Patients with Covid-19 in the ICU Develop Thromboembolism Despite Routine Prophylaxis

29 May, 2020 | 03:17h | UTC

Routine Venous Thromboembolism Prophylaxis May Be Inadequate in the Hypercoagulable State of Severe Coronavirus Disease 2019 – Critical Care Medicine

 


WHO Interim Guidance: Clinical Management of COVID-19

28 May, 2020 | 10:02h | UTC

Clinical management of COVID-19 – World Health Organization

 


Systematic Review: Hydroxychloroquine or Chloroquine for Treatment or Prophylaxis of COVID-19

28 May, 2020 | 09:59h | UTC

Hydroxychloroquine or Chloroquine for Treatment or Prophylaxis of COVID-19: A Living Systematic Review – Annals of Internal Medicine

 


Remdesivir for Covid-19: A 5-day Course is Similarly Effective as a 10-day Course

28 May, 2020 | 10:00h | UTC

Remdesivir for 5 or 10 Days in Patients with Severe Covid-19 – New England Journal of Medicine

 


Study: No Evidence Blanket ‘Do-not-resuscitate’ Orders for COVID-19 Patients are Necessary

28 May, 2020 | 09:50h | UTC

No evidence blanket ‘do-not-resuscitate’ orders for COVID-19 patients are necessary – American Heart Association

Original Study: Survival After In-Hospital Cardiac Arrest In Critically Ill Patients: Implications For Covid-19 Outbreak? – Circulation: Cardiovascular Quality and Outcomes

 


Just the Facts: What Drugs are Safe and Effective for COVID-19?

27 May, 2020 | 02:31h | UTC

Just the Facts: What drugs are safe and effective for COVID-19? – Canadian Journal of Emergency Medicine

Related Guidelines: NIH Coronavirus Disease 2019 (COVID-19) Treatment Guidelines – National Institutes of Health AND Infectious Diseases Society of America Guidelines on the Treatment and Management of Patients with COVID-19 Infection

“Apart from supportive care, there are no current effective therapeutics for COVID-19”

 


Clinical Guidance: Advanced Pulmonary and Cardiac Support of COVID-19 Patients

27 May, 2020 | 02:27h | UTC

Advanced Pulmonary and Cardiac Support of COVID-19 Patients: Emerging Recommendations From ASAIOa Living Working Document – Circulation: Heart Failure

 


Meta-analysis: Efficacy and Safety of Convalescent Plasma for Severe COVID-19

27 May, 2020 | 02:21h | UTC

Efficacy and safety of convalescent plasma for severe COVID-19 based on evidence in other severe respiratory viral infections: a systematic review and meta-analysis – Canadian Medical Association Journal

 


Duration of Prone Position Sessions: A Prospective Cohort Study

27 May, 2020 | 02:20h | UTC

Duration of prone position sessions: a prospective cohort study – Annals of Intensive Care

 


Meta-Analysis: Vasopressin or Its Analogs are Not Associated with Reduced Mortality Compared to Catecholamines Alone in Patients with Septic Shock

27 May, 2020 | 02:13h | UTC

Clinical Efficiency of Vasopressin or Its Analogs in Comparison with Catecholamines Alone on Patients With Septic Shock: A Systematic Review and Meta-Analysis – Frontiers in Pharmacology

Related Review: Vasopressin and its analogues in shock states: a review – Annals of Intensive Care (free)

 


Review: COVID-19 and Cardiovascular Disease

26 May, 2020 | 10:05h | UTC

COVID-19 and Cardiovascular Disease – Circulation

Related Guidelines: COVID-19 rapid guideline: acute myocardial injury – National Institute for Health and Care Excellence AND ESC Guidance for the Diagnosis and Management of CV Disease during the COVID-19 Pandemic – European Society of Cardiology AND Management of Acute Myocardial Infarction During the COVID-19 Pandemic – Journal of the American Academy of Cardiology

 


Podcast: Evidence-Based Medicine for the Management of COVID-19 ARDS

26 May, 2020 | 09:57h | UTC

Critical Perspective: Evidence-Based Medicine for the Management of COVID-19 ARDS – American Thoracic Society

Related Perspective from the Author: In Defense of Evidence-Based Medicine for the Treatment of COVID-19 ARDS – Annals of the American Thoracic Society

 


Clinical Guidance: Intravenous Fluid Therapy in the Perioperative and Critical Care Setting

26 May, 2020 | 09:28h | UTC

Intravenous fluid therapy in the perioperative and critical care setting: Executive summary of the International Fluid Academy (IFA) – Annals of Intensive Care

 


Remdesivir for the Treatment of Covid-19 — Preliminary Report

25 May, 2020 | 02:06h | UTC

Remdesivir for the Treatment of Covid-19 — Preliminary Report – New England Journal of Medicine

Commentaries: Preliminary report on NIAID trial of remdesivir – PulmCrit AND Peer-reviewed data shows remdesivir for COVID-19 improves time to recovery – National Institutes of Health AND Covid-19 study details benefits of treatment with remdesivir, and also its limitations – STAT

 

Related Commentary on Twitter (Thread – Click for more)

 


Hydroxychloroquine and Chloroquine for Covid-19: Large Observational Analysis Finds No Benefit and Possible Harm

25 May, 2020 | 02:03h | UTC

Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis – The Lancet

Commentaries: Chloroquine or hydroxychloroquine for COVID-19: why might they be hazardous? – The Lancet AND What a big new study on malaria drugs as Covid-19 treatments tells us — and what it doesn’t – STAT AND Hydroxychloroquine May Cause More Harm Than Benefit To COVID-19 Patients, Says New Lancet Study – Health Policy Watch

 


Meta-Analysis: Corticosteroids May Reduce Mortality for Patients with COVID-19 and ARDS

25 May, 2020 | 01:45h | UTC

Efficacy and safety of corticosteroids in COVID-19 based on evidence for COVID-19, other coronavirus infections, influenza, community-acquired pneumonia and acute respiratory distress syndrome: a systematic review and meta-analysis – Canadian Medical Association Journal

Related: Early Short Course Corticosteroids in Hospitalized Patients with COVID-19 – Clinical Infectious Diseases

 


Clinical Guidance: Thromboembolism and Anticoagulant Therapy During the COVID-19 Pandemic

25 May, 2020 | 01:43h | UTC

Thromboembolism and anticoagulant therapy during the COVID-19 pandemic: interim clinical guidance from the anticoagulation forum – Journal of Thrombosis and Thrombolysis

Related: Coagulation abnormalities and thrombosis in patients with COVID-19 – The Lancet AND COVID-19 and its implications for thrombosis and anticoagulation – Blood AND Prevention and Treatment of Venous Thromboembolism Associated with Coronavirus Disease 2019 Infection: A Consensus Statement before Guidelines – Thrombosis and Haemostasis AND Thrombosis and COVID-19: FAQs For Current Practice – American College of Cardiology

 


Systematic Review: Ventilation Techniques and Risk for Transmission of Coronavirus Disease, Including COVID-19

25 May, 2020 | 01:40h | UTC

Ventilation Techniques and Risk for Transmission of Coronavirus Disease, Including COVID-19: A Living Systematic Review of Multiple Streams of Evidence – Annals of Internal Medicine

 


[Abstract Only] Randomized Trial: Haloperidol Effective for the Treatment of Headache in the Emergency Department

25 May, 2020 | 01:33h | UTC

Treatment of Headache in the Emergency Department: Haloperidol in the Acute Setting (THE-HA Study): A Randomized Clinical Trial – The Journal of Emergency Medicine

 


Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19

22 May, 2020 | 04:59h | UTC

Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19 – New England Journal of Medicine

Commentary: Lungs of deceased COVID-19 patients show distinctive features – Brigham and Women’s Hospital

Related: Postmortem Examination of Patients With COVID-19 – JAMA AND Pulmonary Arterial Thrombosis in COVID-19 With Fatal Outcome: Results From a Prospective, Single-Center, Clinicopathologic Case Series – Annals of Internal Medicine AND Pathological evidence of pulmonary thrombotic phenomena in severe COVID-19 – Journal of Thrombosis and Haemostasis

 


Choosing Wisely in the COVID-19 Era: Preventing Harm to Healthcare Workers

22 May, 2020 | 04:58h | UTC

Choosing Wisely in the COVID-19 Era: Preventing Harm to Healthcare Workers – Journal of Hospital Medicine

 


SARS2-CoV-2 and Stroke in a New York Healthcare System

22 May, 2020 | 04:56h | UTC

SARS2-CoV-2 and Stroke in a New York Healthcare System – Stroke

News Release: Stroke rates among COVID-19 patients are low, but cases are more severe; overall stroke hospital admissions are down globally – American Heart Association

Commentary: COVID-19 patients may have lower stroke rates than previously suggested – NYU Grossman School of Medicine

 


15 Drugs Being Tested to Treat COVID-19 and How They Would Work

22 May, 2020 | 04:52h | UTC

15 drugs being tested to treat COVID-19 and how they would work – Nature

 


[Preprint] IL6 Inhibition in Critically Ill COVID-19 Patients is Associated with Increased Secondary Infections

22 May, 2020 | 04:44h | UTC

IL6 inhibition in critically ill COVID-19 patients is associated with increased secondary infections – medRxiv

 


Wide Complex Tachycardia Differentiation: A Reappraisal of the State‐of‐the‐Art

22 May, 2020 | 04:38h | UTC

Wide Complex Tachycardia Differentiation: A Reappraisal of the State‐of‐the‐Art – Journal of the American Heart Association