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Emergency Medicine

Conflicting results from 2 randomized trials testing Tocilizumab for Covid-19

26 Feb, 2021 | 08:48h | UTC

Study 1: Tocilizumab in Hospitalized Patients with Severe Covid-19 Pneumonia – New England Journal of Medicine

Study 2: Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19 – New England Journal of Medicine

Editorial: Interleukin-6 Receptor Inhibition in Covid-19 — Cooling the Inflammatory Soup – New England Journal of Medicine

 

Commentary on Twitter

 


Cohort study: A single conventional Troponin combined with HEART score may be as good as serial measurements for safe discharge of patients with chest pain in the ED

26 Feb, 2021 | 08:32h | UTC

Single vs Serial Measurements of Cardiac Troponin Level in the Evaluation of Patients in the Emergency Department With Suspected Acute Myocardial Infarction – JAMA Network Open

Editorial: Troponin Testing in the Emergency Department—When 2 Become 1

Commentary: Single Troponin Test May Be Enough for Safe Discharge of Chest Pain Patients – TCTMD

 


RCT: Dimenhydrinate and metoclopramide equally effective in the treatment of nausea due to vertigo

26 Feb, 2021 | 08:12h | UTC

Comparison of efficacy dimenhydrinate and metoclopramide in the treatment of nausea due to vertigo; a randomized study – The American Journal of Emergency Medicine (link to abstract – $ for full-text)

 


Position Paper: Management of drug-induced liver injury

25 Feb, 2021 | 08:27h | UTC

Drug-induced liver injury: A management position paper from the Latin American Association for Study of the liver – Annals of Hepatology

 


Sepsis treatment: Another trial shows no benefit from the combination of Vitamin C, Thiamine, and Hydrocortisone

24 Feb, 2021 | 02:25h | UTC

Effect of Vitamin C, Thiamine, and Hydrocortisone on Ventilator- and Vasopressor-Free Days in Patients With Sepsis: The VICTAS Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Hydrocortisone, Vitamin C, and Thiamine for Treatment of Sepsis: Making Evidence Matter

Related: The VITAMINS Randomized Clinical Trial: Vitamin C, Hydrocortisone, and Thiamine Not beneficial for Patients with Sepsis (study and commentaries)

 

Commentary on Twitter

 


Diverticulitis: Observational study in outpatients suggests amoxicillin-clavulanate is a safe and effective option compared with metronidazole-fluoroquinolone

24 Feb, 2021 | 02:16h | UTC

Comparative Effectiveness and Harms of Antibiotics for Outpatient Diverticulitis: Two Nationwide Cohort Studies – Annals of Internal Medicine

Commentaries: Amoxicillin-clavulanate safe and effective compared with metronidazole-with-fluoroquinolone for diverticulitis – American College of Physicians AND Study supports fluoroquinolone-sparing treatment for diverticulitis – CIDRAP

 


RCT: Topical intranasal tranexamic acid does not reduce the need for nasal packing in epistaxis

21 Feb, 2021 | 22:02h | UTC

The Use of Tranexamic Acid to Reduce the Need for Nasal Packing in Epistaxis (NoPAC): Randomized Controlled Trial – Annals of Emergency Medicine (link to abstract – $ for full-text)

 

Commentary on Twitter

 


FDA issues alert on ‘limitations’ of pulse oximeters, without explicit mention of racial bias

23 Feb, 2021 | 02:03h | UTC

FDA issues alert on ‘limitations’ of pulse oximeters, without explicit mention of racial bias – STAT

FDA Safety Alert: Pulse Oximeter Accuracy and Limitations: FDA Safety Communication – U.S. Food & Drug Administration

Related: “Racial Bias in Pulse Oximetry Measurement”. In two large cohorts, Black patients had nearly three times the frequency of occult hypoxemia that was not detected by pulse oximetry as White patients – New England Journal of Medicine (study and commentaries)

 


Editorial: Prophylactic anticoagulation for patients in hospital with covid-19

23 Feb, 2021 | 01:59h | UTC

Prophylactic anticoagulation for patients in hospital with covid-19 – The BMJ

Related: Full-dose Heparin best for moderate COVID-19 regardless of D-dimer — Data released from ACTIV-4a, ATTACC, and REMAP-CAP trials AND Cohort study: Early initiation of prophylactic anticoagulation linked to reduced mortality in patients admitted to hospital with Covid-19

 


RCT: Five oral analgesics (including opioids) are equally effective for the treatment of acute musculoskeletal extremity pain in the emergency department

21 Feb, 2021 | 21:39h | UTC

A Randomized Trial Comparing the Efficacy of Five Oral Analgesics for Treatment of Acute Musculoskeletal Extremity Pain in the Emergency Department – Annals of Emergency Medicine (link to abstract – $ for full-text)

 

Commentary on Twitter

 


SOFA score is not accurate enough for mortality prediction in severely ill patients with COVID-19 pneumonia

19 Feb, 2021 | 02:44h | UTC

Determining the Probable Mortality of Patients With COVID-19 Pneumonia Requiring Mechanical Ventilation – JAMA

 

Commentary on Twitter

 


RCT: Vitamin D3 does not improve outcomes in hospitalized patients with moderate to severe COVID-19

18 Feb, 2021 | 03:20h | UTC

Effect of a Single High Dose of Vitamin D3 on Hospital Length of Stay in Patients With Moderate to Severe COVID-19: A Randomized Clinical Trial – JAMA

Editorial: Vitamin D3 to Treat COVID-19: Different Disease, Same Answer

 

 


Video: Emergency intubation in Covid-19

18 Feb, 2021 | 03:16h | UTC

Emergency Intubation in Covid-19 – New England Journal of Medicine

 


Patient characteristics and clinical outcomes of Type 1 vs. Type 2 myocardial infarction

18 Feb, 2021 | 02:54h | UTC

Patient Characteristics and Clinical Outcomes of Type 1 Versus Type 2 Myocardial Infarction – Journal of the American Academy of Cardiology (link to abstract – $ for full-text)

 

Commentary on Twitter

 


Cardiac arrest in COVID-19: characteristics and outcomes of in- and out-of-hospital cardiac arrest

17 Feb, 2021 | 01:32h | UTC

Cardiac arrest in COVID-19: characteristics and outcomes of in- and out-of-hospital cardiac arrest. A report from the Swedish Registry for Cardiopulmonary Resuscitation – European Heart Journal

Commentary: People infected with COVID-19 have a higher risk of dying after a cardiac arrest – European Society of Cardiology

 

Commentary on Twitter

 


Incidence rate and clinical impacts of arrhythmia following COVID-19: a systematic review and meta-analysis of 17,435 patients

17 Feb, 2021 | 01:31h | UTC

Incidence rate and clinical impacts of arrhythmia following COVID-19: a systematic review and meta-analysis of 17,435 patients – Critical Care

 


How effective is magnesium in for the treatment of migraine?

16 Feb, 2021 | 01:48h | UTC

How Effective is Magnesium in your MAGraine Cocktail? – Journal Feed

Original study: MAGraine: Magnesium compared to conventional therapy for treatment of migraines – American Journal of Emergency Medicine

 


Review: Diagnostics for SARS-CoV-2 infections

16 Feb, 2021 | 02:20h | UTC

Diagnostics for SARS-CoV-2 infections – Nature Materials

 


Potential health and economic impacts of dexamethasone treatment for patients with COVID-19

16 Feb, 2021 | 02:10h | UTC

Potential health and economic impacts of dexamethasone treatment for patients with COVID-19 – Nature Communications

 

Commentary on Twitter

 


Small RCT: No effect from Zinc and Vitamin C supplementation among ambulatory patients with SARS-CoV-2 infection

15 Feb, 2021 | 01:20h | UTC

Effect of High-Dose Zinc and Ascorbic Acid Supplementation vs Usual Care on Symptom Length and Reduction Among Ambulatory Patients With SARS-CoV-2 Infection: The COVID A to Z Randomized Clinical Trial – JAMA Network Open

Commentaries: Vitamin C, zinc don’t lessen Covid-19 symptoms, study finds – CNN AND Supplements for the Treatment of Mild COVID-19—Challenging Health Beliefs With Science From A to Z – JAMA Network Open AND Zinc, vitamin C show no effect for COVID-19 in small study – CIDRAP AND Expert reaction to a study looking at prophylactic anticoagulants as a treatment for hospitalised patients with COVID-19 – Science Media Centre

 

Commentary on Twitter

 


Cohort study: Early initiation of prophylactic anticoagulation linked to reduced mortality in patients admitted to hospital with Covid-19

15 Feb, 2021 | 01:18h | UTC

Early initiation of prophylactic anticoagulation for prevention of coronavirus disease 2019 mortality in patients admitted to hospital in the United States: cohort study – The BMJ

Commentaries: Preventive blood thinning drugs could reduce COVID hospital deaths – London School of Hygiene & Tropical Medicine AND Preventive blood thinning drugs linked to reduced risk of death in COVID-19 patients – The BMJ AND Expert reaction to a study looking at prophylactic anticoagulants as a treatment for hospitalised patients with COVID-19 – Science Media Centre AND

 

Commentary on Twitter

 


Reports of anaphylaxis after receipt of mRNA COVID-19 vaccines in the US

15 Feb, 2021 | 01:13h | UTC

Reports of Anaphylaxis After Receipt of mRNA COVID-19 Vaccines in the US—December 14, 2020-January 18, 2021 – JAMA

Author interview: COVID-19 Vaccine Safety–Anaphylaxis and Allergic Reactions – JAMA

 

Commentary on Twitter

 


RCT: Delayed antibiotic prescription feasible for children with uncomplicated respiratory infections

12 Feb, 2021 | 02:02h | UTC

Delayed Antibiotic Prescription for Children With Respiratory Infections: A Randomized Trial – Pediatrics (link to abstract – $ for full-text)

Commentary: Data support delayed antibiotics in kids with respiratory infections – CIDRAP

 


RCT: Tocilizumab reduces deaths in patients hospitalized with COVID-19

12 Feb, 2021 | 02:25h | UTC

Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): preliminary results of a randomised, controlled, open-label, platform trial – medRxiv

News release: Tocilizumab reduces deaths in patients hospitalised with COVID-19 – University of Oxford

Commentary: Tocilizumab cuts death rate in severe COVID-19, study finds – CIDRAP

 

Commentary on Twitter

 


Guidelines for extracorporeal cardiopulmonary resuscitation in children and adults

11 Feb, 2021 | 01:48h | UTC

Extracorporeal Cardiopulmonary Resuscitation in Adults. Interim Guideline Consensus Statement From the Extracorporeal Life Support Organization – ASAIO Journal

See also: Pediatric Extracorporeal Cardiopulmonary Resuscitation ELSO Guidelines – ASAIO Journal

Commentary: Guidelines for extracorporeal cardiopulmonary resuscitation in children and adults: New ELSO statements in ASAIO Journal – Wolters Kluwer

 

Commentary on Twitter

 


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