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Emergency Medicine

ATS Guideline: Nucleic acid–based testing for noninfluenza viral pathogens in adults with suspected community-acquired pneumonia – Testing should be considered only in patients with severe CAP and in immunocompromised patients

5 May, 2021 | 08:28h | UTC

Nucleic Acid–based Testing for Noninfluenza Viral Pathogens in Adults with Suspected Community-acquired Pneumonia. An Official American Thoracic Society Clinical Practice Guideline

News Release: New clinical practice guideline on community acquired pneumonia – American Thoracic Society

 


Opinion | Manual in‐line stabilization during tracheal intubation: effective protection or harmful dogma?

5 May, 2021 | 08:18h | UTC

Manual in‐line stabilisation during tracheal intubation: effective protection or harmful dogma? – Anaesthesia

 


M-A: Prone positioning of nonintubated patients with Covid-19 improve oxygenation variables without any reported serious adverse events – randomized trials with patient-relevant outcomes such as the need for intubation or mortality rates are required

4 May, 2021 | 08:52h | UTC

Prone Positioning of Nonintubated Patients With Coronavirus Disease 2019—A Systematic Review and Meta-Analysis – Critical Care Medicine (link to abstract – $ for full-text)

 


[Preprint] Preventing disproportionate mortality in ICU overload situations: Empirical evidence from the first COVID-19 wave in Europe – “transferring patients proactively out of developing hotspots to less affected regions, well before high ICU workload situations emerge, will improve patient outcomes”

4 May, 2021 | 08:42h | UTC

Preventing disproportionate mortality in ICU overload situations: Empirical evidence from the first COVID-19 wave in Europe – medRxiv

 


ISCHEMIA trial – days alive out of hospital endpoint was higher in the conservative management group vs. invasive management group at 1 month (30.8 vs 28.4 days), 1 year (362.2 vs 355.9 days), and 2 years (718.4 vs 712.1 days)

4 May, 2021 | 08:41h | UTC

Comparison of Days Alive Out of Hospital With Initial Invasive vs Conservative Management: A Prespecified Analysis of the ISCHEMIA Trial – JAMA Cardiology (free for a limited period)

Original study: ISCHEMIA Trial: Health-Status Outcomes with Initial Invasive vs. Conservative Care in Stable Coronary Disease AND ISCHEMIA Trial: Initial Invasive vs. Conservative Strategy for Stable Coronary Disease AND ISCHEMIA Trial: Health Status after Invasive or Conservative Care in Coronary and Advanced Kidney Disease AND ISCHEMIA Trial: Management of Coronary Disease in Patients with Advanced Kidney Disease

 


Study: Most patients who develop a non-IgE-mediated hypersensitivity reaction to nafcillin can be safely treated with cefazolin

4 May, 2021 | 08:36h | UTC

Tolerability of Cefazolin in Nafcillin-Intolerant Patients for the Treatment of Methicillin-Susceptible Staphylococcus aureus Infections – Clinical Infectious Diseases

Related: Systematic Review and Meta-analysis of the Safety of Antistaphylococcal Penicillins Compared to Cefazolin – Antimicrobial Agents & Chemotherapy

 

Commentary on Twitter

 


RECOVERY trial: In hospitalized COVID-19 patients with hypoxia and systemic inflammation (C-reactive protein ≥75 mg/L), tocilizumab improved survival and other clinical outcomes

3 May, 2021 | 05:47h | UTC

Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial – The Lancet

Invited commentary: Tocilizumab in COVID-19: some clarity amid controversy – The Lancet

 


M-A: Tocilizumab reduces the need for mechanical ventilation in COVID-19 patients, but the randomized trials included in the analysis showed it has no significant effect on the risk of mortality or adverse events

3 May, 2021 | 05:44h | UTC

Efficacy and safety of tocilizumab in COVID-19 patients: A living systematic Review and meta-analysis: first update – Clinical Microbiology and Infection

 


Case series of 12 patients with cerebral venous sinus thrombosis with thrombocytopenia after Ad26.COV2.S vaccination – all women younger than 60 years, with symptoms from 6 to 15 days after vaccination

3 May, 2021 | 05:43h | UTC

US Case Reports of Cerebral Venous Sinus Thrombosis With Thrombocytopenia After Ad26.COV2.S Vaccination, March 2 to April 21, 2021 – JAMA

Editorial: Assessing a Rare and Serious Adverse Event Following Administration of the Ad26.COV2.S Vaccine – JAMA

See also: Safety Monitoring of the Janssen (Johnson & Johnson) COVID-19 Vaccine — United States, March–April 2021 – Centers for Disease Control and Prevention AND Updated Recommendations from the Advisory Committee on Immunization Practices for Use of the Janssen (Johnson & Johnson) COVID-19 Vaccine After Reports of Thrombosis with Thrombocytopenia Syndrome Among Vaccine Recipients — United States, April 2021 – Centers for Disease Control and Prevention

Related: AHA/ASA Guidance: Diagnosis and Management of Cerebral Venous Sinus Thrombosis with Vaccine-Induced Thrombotic Thrombocytopenia – “No heparin products in any dose should be given.”

 


ACG Clinical Guideline: Upper Gastrointestinal and Ulcer Bleeding – RBC transfusion at a threshold of 7 g/dL; Erythromycin infusion is suggested before endoscopy; and endoscopy is suggested within 24 hours after presentation.

3 May, 2021 | 05:27h | UTC

ACG Clinical Guideline: Upper Gastrointestinal and Ulcer Bleeding – The American Journal of Gastroenterology

 


ACG Clinical Guideline: Diagnosis and Management of Idiosyncratic Drug-Induced Liver Injury – antimicrobials, herbal and dietary supplements, and anticancer therapeutics are the most common classes of agents

3 May, 2021 | 05:22h | UTC

ACG Clinical Guideline: Diagnosis and Management of Idiosyncratic Drug-Induced Liver Injury – The American Journal of Gastroenterology

 


Study: Patients with heart failure have a much higher incidence of pneumonia than matched individuals in the population. The development of pneumonia in these patients is associated with a 3- to 4-fold higher risk of cardiovascular and all-cause death.

3 May, 2021 | 05:18h | UTC

Incidence and Outcomes of Pneumonia in Patients With Heart Failure – Journal of the American College of Cardiology

Commentaries: Pneumonia in HF Patients Is Common, Lethal, and Preventable – TCTMD AND Outcomes of Pneumonia in Patients With Heart Failure – American College of Cardiology

 


M-A: Delayed antibiotic prescribing for respiratory tract infections is a safe and effective strategy for most patients

30 Apr, 2021 | 08:33h | UTC

Delayed antibiotic prescribing for respiratory tract infections: individual patient data meta-analysis – The BMJ

Commentaries: Delayed Antibiotic Prescribing Safe for Respiratory Tract Infection – HealthDay

 


AHA/ASA Guidance: Diagnosis and Management of Cerebral Venous Sinus Thrombosis with Vaccine-Induced Thrombotic Thrombocytopenia – “No heparin products in any dose should be given.”

30 Apr, 2021 | 08:25h | UTC

Diagnosis and Management of Cerebral Venous Sinus Thrombosis with Vaccine-Induced Thrombotic Thrombocytopenia – Stroke

News release: Guidance on treatment for rare blood clots and low platelets related to COVID-19 vaccine – American Heart Association

Related: ISTH Interim Guidance for the Diagnosis and Treatment on Vaccine Induced Immune Thrombotic Thrombocytopenia

 


Study with 6.9 million people in England shows severe Covid-19 in young people can mostly be explained by obesity – At a BMI of more than 23 kg/m2, there was a linear increase in risk of severe COVID-19

30 Apr, 2021 | 08:22h | UTC

Associations between body-mass index and COVID-19 severity in 6·9 million people in England: a prospective, community-based, cohort study – The Lancet Diabetes & Endocrinology

Commentaries: Severe COVID in young people can mostly be explained by obesity – new study – The Conversation AND Obesity studies highlight severe COVID outcomes, even in young adults – CIDRAP AND Expert reaction to study looking at a potential link between body weight and risk of severe COVID-19, especially for younger adults – Science Media Centre

 

Commentary on Twitter (thread – click for more)

 


Review: COVID-19-associated coagulopathy and antithrombotic agents – In non-critically ill hospitalized patients, therapeutic dose anticoagulation may improve clinical outcomes. In critically ill patients, this same treatment does not improve outcomes, and prophylactic dose anticoagulation is recommended

29 Apr, 2021 | 08:46h | UTC

COVID-19-associated coagulopathy and antithrombotic agents—lessons after 1 year – The Lancet Haematology

Related: Full-dose Heparin best for moderate COVID-19 regardless of D-dimer — Data released from ACTIV-4a, ATTACC, and REMAP-CAP trials AND RCT: Intermediate-dose enoxaparin (1 mg/kg/d) not better than standard-dose prophylactic anticoagulation in patients with Covid-19 admitted to the intensive care unit

 

Commentary on Twitter

 


Ethics Commission Position Statement: Admission criteria and management of critical care patients in a pandemic context – “Age cannot be used as the sole criterion for admission nor denial of access to ICU settings”

29 Apr, 2021 | 08:36h | UTC

Admission criteria and management of critical care patients in a pandemic context: position of the Ethics Commission of the French Intensive Care Society, update of April 2021 – Annals of Intensive Care

 


ACP Guideline: Appropriate Use of High-Flow Nasal Oxygen in Hospitalized Patients – “use high-flow nasal oxygen rather than noninvasive ventilation in hospitalized adults for the management of acute hypoxemic respiratory failure”

29 Apr, 2021 | 08:34h | UTC

Appropriate Use of High-Flow Nasal Oxygen in Hospitalized Patients for Initial or Postextubation Management of Acute Respiratory Failure: A Clinical Guideline From the American College of Physicians – Annals of Internal Medicine

News release: ACP releases new recommendations for appropriate use of high-flow nasal oxygen in hospitalized patients with acute respiratory failure – American College of Physicians

 


M-A: Administration of vasopressor medications through a peripheral intravenous catheter is associated with low risk of adverse events

29 Apr, 2021 | 08:19h | UTC

Adverse events associated with administration of vasopressor medications through a peripheral intravenous catheter: a systematic review and meta-analysis – Critical Care

Related Meta-Analysis: Complication of vasopressor infusion through peripheral venous catheter (study and commentary on Twitter)

 


Review: Systemic and organ-specific immune-related manifestations of COVID-19 – over 70 different systemic and organ-specific immune-related disorders have been reported

28 Apr, 2021 | 08:42h | UTC

Systemic and organ-specific immune-related manifestations of COVID-19 – Nature Reviews Rheumatology

 


How the UK found the first effective Covid-19 treatment — and saved a million lives (about the RECOVERY trial and the effects of Dexamethasone)

28 Apr, 2021 | 08:36h | UTC

How the UK found the first effective Covid-19 treatment — and saved a million lives – Vox

Related: Covid-19: The Inside Story of the RECOVERY Trial AND Covid: The London bus trip that saved maybe a million lives – BBC

 


Overview of SARS-CoV-2 infection in adults living with HIV – Low CD4 cell counts, or untreated HIV infection is associated a more severe clinical course

28 Apr, 2021 | 08:32h | UTC

Overview of SARS-CoV-2 infection in adults living with HIV – The Lancet HIV

 

Commentary on Twitter

 


American Academy of Orthopedic Surgeons Clinical Practice Guideline Summary for Limb Salvage or Early Amputation

28 Apr, 2021 | 08:14h | UTC

American Academy of Orthopaedic Surgeons Clinical Practice Guideline Summary for Limb Salvage or Early Amputation – Journal of the American Academy of Orthopaedic Surgeons

 


NICE publishes updated clinical guideline on the diagnosis and management of atrial fibrillation

27 Apr, 2021 | 09:33h | UTC

Guideline: Atrial fibrillation: diagnosis and management – National Institute for Health and Care Excellence

News release: NICE publishes updated clinical guideline on the diagnosis and management of atrial fibrillation – National Institute for Health and Care Excellence

 


ACP Guideline: Appropriate Use of Point-of-Care Ultrasonography in Patients With Acute Dyspnea in Emergency Department or Inpatient Settings

27 Apr, 2021 | 09:31h | UTC

Appropriate Use of Point-of-Care Ultrasonography in Patients With Acute Dyspnea in Emergency Department or Inpatient Settings: A Clinical Guideline From the American College of Physicians – Annals of Internal Medicine

 


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