Pediatrics – Hematology/Oncology
Expert consensus for plasma and platelet transfusion practice in critically ill children.
20 Jan, 2022 | 08:44h | UTC
RCT: Sirolimus plus prednisolone vs. sirolimus monotherapy for kaposiform hemangioendothelioma.
18 Jan, 2022 | 09:08h | UTCSirolimus plus prednisolone vs sirolimus monotherapy for kaposiform hemangioendothelioma: a randomized clinical trial – Blood (link to abstract – $ for full-text)
Best Practice Recommendations: Management of adults and children receiving CAR T-cell therapy.
12 Jan, 2022 | 08:31h | UTC
RCT: In children with sickle cell anemia, hydroxyurea in moderate doses (20 mg/kg per day) is not better than low doses (10 mg/kg per day) for primary stroke prevention.
11 Jan, 2022 | 02:10h | UTCHydroxyurea for primary stroke prevention in children with sickle cell anaemia in Nigeria (SPRING): a double-blind, multicentre, randomised, phase 3 trial – The Lancet Haematology (link to abstract – $ for full-text)
Non-inferiority randomized trial showed radiotherapy can be safely omitted in many children and adolescents with intermediate-stage and advanced-stage classical Hodgkin lymphoma.
10 Dec, 2021 | 10:04h | UTC
Clinical pharmacology of cytotoxic drugs in neonates and infants: Providing evidence-based dosing guidance.
7 Dec, 2021 | 08:47h | UTC
The global burden of adolescent and young adult cancer in 2019: a systematic analysis for the Global Burden of Disease Study 2019.
5 Dec, 2021 | 23:09h | UTCInvited Commentary: Burden of cancer in adolescents and young adults – The Lancet Oncology
Guideline for the laboratory diagnosis of iron deficiency in adults (excluding pregnancy) and children.
25 Nov, 2021 | 10:31h | UTC
Novel gene therapy for hemophilia A leads to sustained expression of clotting factor and reduced bleeding events.
19 Nov, 2021 | 10:25h | UTCOriginal Study: Multiyear Factor VIII Expression after AAV Gene Transfer for Hemophilia A – New England Journal of Medicine
Commentary on Twitter
3.5 years after therapy with factor VIII-containing adeno-associated virus, 16 of 18 men with hemophilia A had enough factor VIII expression that bleeding events were reduced to nearly zero and prophylaxis was discontinued. https://t.co/n3cPyjGDkn pic.twitter.com/vPyz0OmT1S
— NEJM (@NEJM) November 18, 2021
Assessment of arsenic trioxide and all-trans retinoic acid for the treatment of pediatric acute promyelocytic leukemia.
14 Nov, 2021 | 19:32h | UTCNews release: Drug combination helps children with acute promyelocytic leukemia avoid conventional chemotherapy – NIH News Releases
Commentary on Twitter
Clinical trial showed that pediatric patients with acute promyelocytic leukemia (APL) have very high cure rates with treatment regimen that uses targeted therapy and no cytotoxic chemotherapy for standard risk APL or limited anthracycline for high risk APL https://t.co/V3mahhIb6Y
— JAMA Oncology (@JAMAOnc) November 11, 2021
Cohort study: In utero exposure to 17α-hydroxyprogesterone caproate linked to increased risk of cancer in offspring.
10 Nov, 2021 | 06:59h | UTCIn utero exposure to 17α-hydroxyprogesterone caproate and risk of cancer in offspring – American Journal of Obstetrics and Gynecology (link to abstract – $ for full-text)
A national HPV vaccination program in England was associated with an estimated reduction in cervical cancer rates of 87% for those offered the vaccine at age 12–13 years.
4 Nov, 2021 | 09:58h | UTCRelated:
CDC: 92% of Human Papillomavirus–Attributable Cancers can be Targeted by HPV Vaccination
Meta-Analysis: Population-level Impact of HPV Vaccination Programs
Commentary on Twitter
NEW—Cervical cancer rates 87% lower in women offered vaccination against human papillomavirus (#HPV) between ages 12-13 than in previous generations, English study confirms.
First direct evidence of cervical cancer prevention using bivalent vaccine: https://t.co/HdQbGIKxZp pic.twitter.com/PMFermHGOv
— The Lancet (@TheLancet) November 3, 2021
Systematic Review: Prophylactic antibiotics for preventing gram‐positive infections associated with long‐term central venous catheters in adults and children receiving treatment for cancer.
28 Oct, 2021 | 09:58h | UTC
Review: Wilms Tumor.
19 Oct, 2021 | 08:44h | UTCWilms tumour – Nature Reviews Disease Primers (free for a limited period)
Infographic: Wilms tumour
Commentary on Twitter
This is a schematic showing the timeline of key advances that established the modern clinical management of children with #Wilms tumour https://t.co/lT9ECVeuiZ pic.twitter.com/7KbMSo7qY3
— Nature Reviews Disease Primers (@DiseasePrimers) October 15, 2021
AAP Guideline: Long-term follow-up care for childhood, adolescent, and young adult cancer survivors.
3 Sep, 2021 | 10:17h | UTCLong-term Follow-up Care for Childhood, Adolescent, and Young Adult Cancer Survivors – Pediatrics
European PanCare Follow Up Recommendations for surveillance of late effects of childhood, adolescent, and young adult cancer.
1 Aug, 2021 | 23:59h | UTC
Survival outcomes for cancer types with the highest death rates for adolescents and young adults, 1975-2016.
1 Aug, 2021 | 23:58h | UTCCommentary: Survival Trends for Adolescents and Young Adults With Cancer: 40-Year Analysis – The ASCO Post
Transfusion management of severe anemia in African children: a consensus algorithm.
25 May, 2021 | 08:32h | UTC
Recent progress in the treatment of cancer in children
5 Apr, 2021 | 01:15h | UTCRecent progress in the treatment of cancer in children – CA: A Cancer Journal for Clinicians
Preliminary study finds a low-calorie diet and mild exercise may improve survival for young people with leukemia
2 Apr, 2021 | 09:12h | UTC
Rethinking Success in Pediatric Oncology: Beyond 5-Year Survival
31 Mar, 2021 | 02:56h | UTCRethinking Success in Pediatric Oncology: Beyond 5-Year Survival – Journal of Clinical Oncology
Systematic review: Prophylactic antibiotics for preventing pneumococcal infection in children with sickle cell disease
23 Mar, 2021 | 02:09h | UTC
Global patterns and trends in incidence and mortality of thyroid cancer in children and adolescents: a population-based study
5 Mar, 2021 | 08:10h | UTCGlobal patterns and trends in incidence and mortality of thyroid cancer in children and adolescents: a population-based study – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)
Commentaries: Global thyroid cancer overdiagnosis in children and adolescents – MDEdge (free registration required) AND Global Thyroid Cancer Overdiagnosis in Children and Adolescents – Medscape (free registration required)
Commentary on Twitter
New #IARCpaper shows the incidence of thyroid cancer in children & adolescents, a rare condition everywhere before 2000, has increased rapidly in recent years in many countries, & suggests overdiagnosis is likely to be the main driver of these increases https://t.co/1ct8iEJSty pic.twitter.com/JIjBBAyKNv
— IARC (@IARCWHO) January 20, 2021
RCT: Effect of Blinatumomab vs. Chemotherapy in children with high-risk first-relapse B-Cell Acute Lymphoblastic Leukemia
3 Mar, 2021 | 08:19h | UTCEffect of Blinatumomab vs Chemotherapy on Event-Free Survival Among Children With High-risk First-Relapse B-Cell Acute Lymphoblastic Leukemia: A Randomized Clinical Trial – JAMA (free for a limited period)
Related study: Effect of Postreinduction Therapy Consolidation With Blinatumomab vs Chemotherapy on Disease-Free Survival in Children, Adolescents, and Young Adults With First Relapse of B-Cell Acute Lymphoblastic Leukemia: A Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Blinatumomab for Treatment of Children With High-risk Relapsed B-Cell Acute Lymphoblastic Leukemia – JAMA (free for a limited period)
Bleeding in critically ill children—review of literature, knowledge gaps, and suggestions for future investigation
19 Feb, 2021 | 02:23h | UTC