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Pediatrics – Hematology/Oncology

Expert consensus for plasma and platelet transfusion practice in critically ill children.

20 Jan, 2022 | 08:44h | UTC

Executive Summary of Recommendations and Expert Consensus for Plasma and Platelet Transfusion Practice in Critically Ill Children: From the Transfusion and Anemia EXpertise Initiative—Control/Avoidance of Bleeding (TAXI-CAB) – Pediatric Critical Care Medicine

 


RCT: Sirolimus plus prednisolone vs. sirolimus monotherapy for kaposiform hemangioendothelioma.

18 Jan, 2022 | 09:08h | UTC

Sirolimus plus prednisolone vs sirolimus monotherapy for kaposiform hemangioendothelioma: a randomized clinical trial – Blood (link to abstract – $ for full-text)

 


Best Practice Recommendations: Management of adults and children receiving CAR T-cell therapy.

12 Jan, 2022 | 08:31h | UTC

Management of Adults and Children receiving CAR T-cell therapy: 2021 Best Practice Recommendations of the European Society for Blood and Marrow Transplantation (EBMT) and the Joint Accreditation Committee of ISCT and EBMT (JACIE) and the European Haematology Association (EHA) – Annals of Oncology

 


RCT: In children with sickle cell anemia, hydroxyurea in moderate doses (20 mg/kg per day) is not better than low doses (10 mg/kg per day) for primary stroke prevention.

11 Jan, 2022 | 02:10h | UTC

Hydroxyurea for primary stroke prevention in children with sickle cell anaemia in Nigeria (SPRING): a double-blind, multicentre, randomised, phase 3 trial – The Lancet Haematology (link to abstract – $ for full-text)

 


Non-inferiority randomized trial showed radiotherapy can be safely omitted in many children and adolescents with intermediate-stage and advanced-stage classical Hodgkin lymphoma.

10 Dec, 2021 | 10:04h | UTC

Response-adapted omission of radiotherapy and comparison of consolidation chemotherapy in children and adolescents with intermediate-stage and advanced-stage classical Hodgkin lymphoma (EuroNet-PHL-C1): a titration study with an open-label, embedded, multinational, non-inferiority, randomised controlled trial – The Lancet Oncology

 


Clinical pharmacology of cytotoxic drugs in neonates and infants: Providing evidence-based dosing guidance.

7 Dec, 2021 | 08:47h | UTC

Clinical pharmacology of cytotoxic drugs in neonates and infants: Providing evidence-based dosing guidance – European Journal of Cancer

 


The global burden of adolescent and young adult cancer in 2019: a systematic analysis for the Global Burden of Disease Study 2019.

5 Dec, 2021 | 23:09h | UTC

The global burden of adolescent and young adult cancer in 2019: a systematic analysis for the Global Burden of Disease Study 2019 – The Lancet Oncology

Invited Commentary: Burden of cancer in adolescents and young adults – The Lancet Oncology

 


Guideline for the laboratory diagnosis of iron deficiency in adults (excluding pregnancy) and children.

25 Nov, 2021 | 10:31h | UTC

Guideline for the laboratory diagnosis of iron deficiency in adults (excluding pregnancy) and children – British Journal of Haematology

 


Novel gene therapy for hemophilia A leads to sustained expression of clotting factor and reduced bleeding events.

19 Nov, 2021 | 10:25h | UTC

News release: Novel gene therapy for hemophilia a leads to sustained expression of clotting factor and reduced bleeding events – Children’s Hospital of Philadelphia

Original Study: Multiyear Factor VIII Expression after AAV Gene Transfer for Hemophilia A – New England Journal of Medicine

 

Commentary on Twitter

 


Assessment of arsenic trioxide and all-trans retinoic acid for the treatment of pediatric acute promyelocytic leukemia.

14 Nov, 2021 | 19:32h | UTC

Assessment of Arsenic Trioxide and All-trans Retinoic Acid for the Treatment of Pediatric Acute Promyelocytic Leukemia: A Report From the Children’s Oncology Group AAML1331 Trial – JAMA Oncology

News release: Drug combination helps children with acute promyelocytic leukemia avoid conventional chemotherapy – NIH News Releases

 

Commentary on Twitter

 


Cohort study: In utero exposure to 17α-hydroxyprogesterone caproate linked to increased risk of cancer in offspring.

10 Nov, 2021 | 06:59h | UTC

In utero exposure to 17α-hydroxyprogesterone caproate and risk of cancer in offspring – American Journal of Obstetrics and Gynecology (link to abstract – $ for full-text)

Commentary: Drug used to prevent miscarriage increases risk of cancer in offspring – The University of Texas Health Science Center at Houston

Related: Randomized Trial: Injectable 17-α-hydroxyprogesterone Not Effective for the Prevention of Recurrent Preterm Birth

 


A national HPV vaccination program in England was associated with an estimated reduction in cervical cancer rates of 87% for those offered the vaccine at age 12–13 years.

4 Nov, 2021 | 09:58h | UTC

The effects of the national HPV vaccination programme in England, UK, on cervical cancer and grade 3 cervical intraepithelial neoplasia incidence: a register-based observational study – The Lancet

Related:

Nationwide cohort study in Sweden shows HPV vaccination linked to reduced risk of invasive cervical cancer

CDC: 92% of Human Papillomavirus–Attributable Cancers can be Targeted by HPV Vaccination

Meta-Analysis: Population-level Impact of HPV Vaccination Programs

 

Commentary on Twitter

 


Systematic Review: Prophylactic antibiotics for preventing gram‐positive infections associated with long‐term central venous catheters in adults and children receiving treatment for cancer.

28 Oct, 2021 | 09:58h | UTC

Prophylactic antibiotics for preventing gram‐positive infections associated with long‐term central venous catheters in adults and children receiving treatment for cancer – Cochrane Library

 


Review: Wilms Tumor.

19 Oct, 2021 | 08:44h | UTC

Wilms tumour – Nature Reviews Disease Primers (free for a limited period)

Infographic: Wilms tumour

 

Commentary on Twitter

 


AAP Guideline: Long-term follow-up care for childhood, adolescent, and young adult cancer survivors.

3 Sep, 2021 | 10:17h | UTC

Long-term Follow-up Care for Childhood, Adolescent, and Young Adult Cancer Survivors – Pediatrics

News release: American Academy of Pediatrics Offers Guidance for Caring and Treatment of Long-Term Cancer Survivors – American Academy of Pediatrics

 


European PanCare Follow Up Recommendations for surveillance of late effects of childhood, adolescent, and young adult cancer.

1 Aug, 2021 | 23:59h | UTC

European PanCare Follow Up Recommendations for surveillance of late effects of childhood, adolescent, and young adult cancer – European Journal of Cancer

 


Survival outcomes for cancer types with the highest death rates for adolescents and young adults, 1975-2016.

1 Aug, 2021 | 23:58h | UTC

Survival outcomes for cancer types with the highest death rates for adolescents and young adults, 1975-2016 – Cancer

Commentary: Survival Trends for Adolescents and Young Adults With Cancer: 40-Year Analysis – The ASCO Post

 


Transfusion management of severe anemia in African children: a consensus algorithm.

25 May, 2021 | 08:32h | UTC

Transfusion management of severe anaemia in African children: a consensus algorithm – British Journal of Haematology

 


Recent progress in the treatment of cancer in children

5 Apr, 2021 | 01:15h | UTC

Recent progress in the treatment of cancer in children – CA: A Cancer Journal for Clinicians

 


Preliminary study finds a low-calorie diet and mild exercise may improve survival for young people with leukemia

2 Apr, 2021 | 09:12h | UTC

Caloric and nutrient restriction to augment chemotherapy efficacy for acute lymphoblastic leukemia: the IDEAL trial – Blood Advances

Commentary: Low-calorie diet and mild exercise improve survival for young people with leukemia – University of California, Los Angeles (UCLA)

 


Rethinking Success in Pediatric Oncology: Beyond 5-Year Survival

31 Mar, 2021 | 02:56h | UTC

Rethinking Success in Pediatric Oncology: Beyond 5-Year Survival – Journal of Clinical Oncology

 


Systematic review: Prophylactic antibiotics for preventing pneumococcal infection in children with sickle cell disease

23 Mar, 2021 | 02:09h | UTC

Prophylactic antibiotics for preventing pneumococcal infection in children with sickle cell disease – Cochrane Library

 


Global patterns and trends in incidence and mortality of thyroid cancer in children and adolescents: a population-based study

5 Mar, 2021 | 08:10h | UTC

Global patterns and trends in incidence and mortality of thyroid cancer in children and adolescents: a population-based study – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)

Commentaries: Global thyroid cancer overdiagnosis in children and adolescents – MDEdge (free registration required) AND Global Thyroid Cancer Overdiagnosis in Children and Adolescents – Medscape (free registration required)

 

Commentary on Twitter

 


RCT: Effect of Blinatumomab vs. Chemotherapy in children with high-risk first-relapse B-Cell Acute Lymphoblastic Leukemia

3 Mar, 2021 | 08:19h | UTC

Effect of Blinatumomab vs Chemotherapy on Event-Free Survival Among Children With High-risk First-Relapse B-Cell Acute Lymphoblastic Leukemia: A Randomized Clinical Trial – JAMA (free for a limited period)

Related study: Effect of Postreinduction Therapy Consolidation With Blinatumomab vs Chemotherapy on Disease-Free Survival in Children, Adolescents, and Young Adults With First Relapse of B-Cell Acute Lymphoblastic Leukemia: A Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Blinatumomab for Treatment of Children With High-risk Relapsed B-Cell Acute Lymphoblastic Leukemia – JAMA (free for a limited period)

 


Bleeding in critically ill children—review of literature, knowledge gaps, and suggestions for future investigation

19 Feb, 2021 | 02:23h | UTC

Bleeding in Critically Ill Children—Review of Literature, Knowledge Gaps, and Suggestions for Future Investigation – Frontiers in Pediatrics

 


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