Pediatrics – Hematology/Oncology
4 or more CT scans in childhood correlate with elevated cancer risk
4 May, 2023 | 13:59h | UTCNews Release: Single CT scan in kids low risk for cancers, but 4 or more CTs increases risk – Canadian Medical Association Journal
Single-arm study | Blinatumomab added to chemotherapy in infant lymphoblastic leukemia
28 Apr, 2023 | 13:08h | UTCBlinatumomab Added to Chemotherapy in Infant Lymphoblastic Leukemia – New England Journal of Medicinev (link to abstract – $ for full-text)
News Release: Immunotherapy strongly improves prognosis of babies with leukemia – Princess Máxima Center
Commentary on Twitter
In this study, the addition of blinatumomab to standard chemotherapy improved disease-free and overall survival among infants with KMT2A-rearranged ALL, with minimal additional toxic effects. https://t.co/fNKOaQQfdN
— NEJM (@NEJM) April 26, 2023
Late mortality in childhood cancer survivors: causes & modifiable risk factors
11 Apr, 2023 | 14:16h | UTCSpecific causes of excess late mortality and association with modifiable risk factors among survivors of childhood cancer: a report from the Childhood Cancer Survivor Study cohort – The Lancet (link to abstract – $ for full-text)
News Release: Healthy lifestyle associated with reduced mortality risk in childhood cancer survivors – St. Jude Children’s Research Hospital
Single-arm study | Effects of CAR-T therapy in children with relapsed or refractory high-risk neuroblastoma
11 Apr, 2023 | 14:09h | UTCGD2-CART01 for Relapsed or Refractory High-Risk Neuroblastoma – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: CAR-T Therapy Helps Kids Battling Deadly Nervous System Tumors – HealthDay
Commentary on Twitter
Patients with neuroblastoma received CAR-positive T cells targeting a disialoganglioside. Of 63% with a response, 33% had a complete response (some durable). Cytokine release syndrome was common. https://t.co/LDaIoeGfV7
Read the science behind the study: https://t.co/L4D5x1G6BF pic.twitter.com/VfsQKfSVFf
— NEJM (@NEJM) April 5, 2023
Guidelines on diagnosis and management of chronic neutropenia in adults and children
10 Apr, 2023 | 13:25h | UTC
Commentary on Twitter
Neutropenia diagnosis & management were previously based on physicians' experience or local practices. To harmonize #hematology treatment, #EHA & @eunet_innochron have published a new #EHAGuideline on #neutropenia in adults & children in @Hemasphere_EHA: https://t.co/ifYEtzNlAv pic.twitter.com/CnKuqG03Up
— European Hematology Association (@EHA_Hematology) April 3, 2023
RCT | Ganitumab added to chemotherapy did not improve outcomes in patients with metastatic Ewing sarcoma
30 Mar, 2023 | 14:16h | UTCRandomized Phase III Trial of Ganitumab With Interval-Compressed Chemotherapy for Patients With Newly Diagnosed Metastatic Ewing Sarcoma: A Report From the Children’s Oncology Group – Journal of Clinical Oncology (link to abstract – $ for full-text)
Commentary: Ganitumab Provides No Benefit in Metastatic Ewing Sarcoma – Cancer Therapy Advisor
Consensus Paper | Cardio-oncology recommendations for pediatric oncology patients
31 Jan, 2023 | 13:54h | UTC
ASCO Guideline | Management of fever and neutropenia in pediatric patients with cancer and hematopoietic cell transplantation recipients
24 Jan, 2023 | 14:28h | UTC
NCCN Guideline | Pediatric central nervous system cancers
12 Jan, 2023 | 13:11h | UTCEditorial: ASCO Living Guidelines: The Next Frontier
Review | Palliative care for adolescents and young adults with advanced illness.
12 Dec, 2022 | 12:33h | UTC
Joint consensus statement on the vaccination of adult and pediatric hematopoietic stem cell transplant recipients.
30 Nov, 2022 | 13:39h | UTC
Guideline | Prevention of acute and delayed chemotherapy-induced nausea and vomiting in pediatric cancer patients.
8 Nov, 2022 | 12:21h | UTC
RCT | Brentuximab Vedotin with chemotherapy in pediatric high-risk Hodgkin’s Lymphoma.
4 Nov, 2022 | 13:30h | UTCBrentuximab Vedotin with Chemotherapy in Pediatric High-Risk Hodgkin’s Lymphoma – New England Journal of Medicine (link to abstract – $ for full-text)
2022 ETA Guidelines for the management of pediatric thyroid nodules and differentiated thyroid carcinoma.
27 Oct, 2022 | 12:33h | UTCCommentary: New EU Guidelines: Individualize Care for Thyroid Cancer in Kids – Medscape (free registration required)
Systematic Review | Dexrazoxane for preventing or reducing cardiotoxicity in adults and children with cancer receiving anthracyclines.
21 Oct, 2022 | 12:47h | UTC
Guideline | Diagnosis and management of febrile neutropenia in patients with cancer.
18 Oct, 2022 | 12:52h | UTCRelated:
Consensus recommendations for screening and managing childhood cancer survivors at risk for cardiomyopathy.
11 Oct, 2022 | 13:35h | UTCRelated:
Cardiometabolic Comorbidities in Cancer Survivors: JACC: CardioOncology State-of-the-Art Review
Brazilian Cardio-oncology Guideline – 2020 – Arquivos Brasileiros de Cardiologia
Retrospective cohort | Outcomes in relapsed neuroblastoma treated with Irinotecan / Temozolomide / Dinutuximab / GM-CSF.
11 Oct, 2022 | 13:30h | UTC
RCT | Effect of the family-centered advance care planning for teens with cancer intervention on sustainability of congruence about end-of-life treatment preferences.
22 Sep, 2022 | 13:02h | UTCNews Release: Advance care planning for adolescents with cancer – University of Minnesota
Commentary: Study Examines Effects of Advance Care Planning for Adolescents With Cancer – The ASCO Post
Commentary on Twitter
Results of this trial showed that, for those who received the FACE®-TC intervention, the families’ knowledge of their adolescents’ end-of-life treatment preferences was sustained for 1 year, suggesting yearly follow-up sessions. @ChildrensNatl #EOL https://t.co/dngUhFQ5vQ
— JAMA Network Open (@JAMANetworkOpen) July 12, 2022
Large study unravels the risk factors for heart failure among childhood cancer survivors.
11 Sep, 2022 | 22:22h | UTC
Cohort Study | Children conceived via assisted reproductive technologies are at increased risk of childhood cancers.
7 Sep, 2022 | 12:32h | UTCAssisted Reproductive Technology and Risk of Childhood Cancers – JAMA Network Open
Invited Commentary: Fertility Treatment and Childhood Cancer Risk – JAMA Network Open
Commentary on Twitter
Children born of assisted reproductive technology (ART) conception was associated with an increased risk of overall childhood cancers compared with those conceived naturally and those with subfertility and non-ART conception. #OpenAccess #Research https://t.co/HylUVE4gFg
— JAMA Network Open (@JAMANetworkOpen) August 31, 2022
Systematic Review | Adverse drug reactions in pediatric onco-hematology
2 Sep, 2022 | 13:05h | UTCAdverse Drug Reactions in Pediatric Oncohematology: A Systematic Review – Frontiers in Pharmacology
Mycosis fungoides in pediatric population: comprehensive review on epidemiology, clinical presentation, and management.
2 Sep, 2022 | 13:02h | UTC
Measuring quality of dying, death and end-of-life care for children and young people: a scoping review of available tools.
26 Aug, 2022 | 13:14h | UTC
M-A | Extent of tumor resection and survival in pediatric patients with high-grade gliomas.
17 Aug, 2022 | 14:00h | UTC
Commentary on Twitter
In this systematic review and meta-analysis of pediatric high-grade gliomas, gross total resection was associated with better overall survival than subtotal resection and biopsy. https://t.co/QpKiDKpYYs
— JAMA Network Open (@JAMANetworkOpen) August 16, 2022