Hematology (All Articles) | Links Medicus Free Medical News & Perspectives

M-A: Guided versus standard antiplatelet therapy in patients undergoing percutaneous coronary intervention

20 Apr, 2021 | 05:40h | UTC

Guided versus standard antiplatelet therapy in patients undergoing percutaneous coronary intervention: a systematic review and meta-analysis – The Lancet

Commentary on Twitter

Great paper on guided vs standard DAPT.
Interestingly outcomes were found to vary according to the strategy used:
ESCALATION was associated with⬇️ISCHEMIC EVENTS (without⬆️bleedings)
DE-ESCALATION was associated with⬇️ BLEEDINGS (without ⬆️ischemic events). https://t.co/y4ys6tvktw

— Gregory A. Sgueglia (@GregorySgueglia) April 16, 2021

Pathologic Antibodies to Platelet Factor 4 after ChAdOx1 nCoV-19 Vaccination

18 Apr, 2021 | 21:43h | UTC

Pathologic Antibodies to Platelet Factor 4 after ChAdOx1 nCoV-19 Vaccination – New England Journal of Medicine

Commentaries: Researchers Offer Algorithm for Managing Thrombosis and Thrombocytopenia After COVID-19 Vaccination – NEJM Journal Watch AND Blood Clots After COVID-19 Vaccination Linked to Immune Response: UK Report – TCTMD AND People with rare blood clots after a COVID-19 jab share an uncommon immune response – ScienceNews

Editorial: SARS-CoV-2 Vaccine–Induced Immune Thrombotic Thrombocytopenia – “The very low prevalence of this complication of vaccination, however severe, relative to the benefits of preventing Covid-19 must be emphasized”

18 Apr, 2021 | 21:42h | UTC

SARS-CoV-2 Vaccine–Induced Immune Thrombotic Thrombocytopenia – New England Journal of Medicine

COVID vaccines and blood clots: five key questions

18 Apr, 2021 | 21:40h | UTC

COVID vaccines and blood clots: five key questions – Nature

Case Report: Thrombotic Thrombocytopenia after Johnson & Johnson Vaccine

15 Apr, 2021 | 07:02h | UTC

Thrombotic Thrombocytopenia after Ad26.COV2.S Vaccination – New England Journal of Medicine

U.S. regulators pause Johnson & Johnson vaccine rollout over rare (1 in a million) cases of blood clots

14 Apr, 2021 | 02:16h | UTC

Joint CDC and FDA Statement on Johnson & Johnson COVID-19 Vaccine – U.S. Food & Drug Administration

Commentaries: Covid-19: US suspends Johnson and Johnson vaccine rollout over blood clots – BMJ AND CDC and FDA recommend US pause use of Johnson & Johnson’s Covid-19 vaccine over blood clot concerns – CNN AND US halts J&J COVID vaccine after reports of blood clots – CIDRAP AND U.S. urges pause on use of Johnson & Johnson Covid-19 vaccine after rare blood clotting cases – CIDRAP

Why would a Covid vaccine cause rare blood clots? Researchers have found clues

14 Apr, 2021 | 02:14h | UTC

Why would a Covid vaccine cause rare blood clots? Researchers have found clues – STAT

Papers Confirm Rare Thrombocytopenia Link to AstraZeneca Vaccine

12 Apr, 2021 | 01:20h | UTC

Papers Confirm Rare Thrombocytopenia Link to AstraZeneca Vaccine – TCTMD

Study 1: Thrombotic Thrombocytopenia after ChAdOx1 nCov-19 Vaccination – New England Journal of Medicine

Study 2: Thrombosis and Thrombocytopenia after ChAdOx1 nCoV-19 Vaccination – New England Journal of Medicine

EMA Reviews Link Between Blood Clots and Johnson & Johnson Vaccine

12 Apr, 2021 | 01:18h | UTC

EMA Reviews Link Between Blood Clots and Johnson & Johnson Vaccine – Health Policy Watch

ESC Position Statement: Diagnosis and treatment of cardiac amyloidosis

8 Apr, 2021 | 08:49h | UTC

Diagnosis and treatment of cardiac amyloidosis: a position statement of the ESC Working Group on Myocardial and Pericardial Diseases – European Heart Journal

Commentary on Twitter (thread – click for more)

ESC position paper on diagnosis & treatment of cardiac amyloidosis published today simultaneously at EHJ & EJHF. https://t.co/ad7xn7c1MY https://t.co/pZ6tOWICpn @escardio @ESC_Journals @ehj_ed @MarcoMetra
Thread👇🏻(1/7) pic.twitter.com/ngsscfd0pB

— Pablo Garcia-Pavia (@dr_pavia) April 7, 2021

WHO Interim statement: A causal relationship between the AstraZeneca COVID-19 vaccine and the occurrence of blood clots with low platelets is considered plausible but is not confirmed

8 Apr, 2021 | 09:09h | UTC

Interim statement of the COVID-19 subcommittee of the WHO Global Advisory Committee on Vaccine Safety on AstraZeneca COVID-19 vaccine – World Health Organization

Commentary on Twitter (thread – click for more)

🆕 Interim statement of the #COVID19 subcommittee of the WHO Global Advisory Committee on Vaccine Safety on the AstraZeneca vaccine https://t.co/p8XMMAiUne pic.twitter.com/7DMRNFxQsX

— World Health Organization (WHO) (@WHO) April 7, 2021

AstraZeneca’s COVID-19 vaccine: EMA finds possible link to very rare cases of unusual blood clots with low blood platelets. The benefits of the vaccine continue to outweigh the risks for people who receive it.

8 Apr, 2021 | 09:07h | UTC

AstraZeneca’s COVID-19 vaccine: EMA finds possible link to very rare cases of unusual blood clots with low blood platelets – European Medicines Agency

Commentaries: In rare instances, AstraZeneca’s Covid-19 vaccine linked to blood clots, regulators say – STAT AND Expert reaction to statements from MHRA and EMA in relation to the AstraZeneca vaccine and rare blood clots and low blood platelets – Science Media Centre

UK regulator confirms that people should continue to receive the COVID-19 vaccine AstraZeneca

8 Apr, 2021 | 09:05h | UTC

UK regulator confirms that people should continue to receive the COVID-19 vaccine AstraZeneca – GOV.UK

Original report: MHRA issues new advice, concluding a possible link between COVID-19 Vaccine AstraZeneca and extremely rare, unlikely to occur blood clots – Medicines and Healthcare products Regulatory Agency

Commentary: Expert reaction to statements from MHRA and EMA in relation to the AstraZeneca vaccine and rare blood clots and low blood platelets – Science Media Centre

Commentary on Twitter

Following suspensions by some countries of the COVID-19 Vaccine AstraZeneca over suspected blood clots, the MHRA confirms that the benefits of the vaccine in preventing COVID-19 far outweigh the risks. People should still go and get their COVID-19 vaccine https://t.co/zse5RUIct1

— Antibiotic Steward🆔🦠Bassam Ghanem (@ABsteward) April 7, 2021

JCVI statement on use of the AstraZeneca COVID-19 vaccine: “JCVI currently advises that it is preferable for adults aged <30 years to be offered an alternative COVID-19 vaccine, if available.”

8 Apr, 2021 | 09:02h | UTC

JCVI statement on use of the AstraZeneca COVID-19 vaccine: 7 April 2021 – GOV.UK

Commentaries: Covid: Under-30s offered alternative to Oxford-AstraZeneca jab – BBC AND Expert reaction to statements from MHRA and EMA in relation to the AstraZeneca vaccine and rare blood clots and low blood platelets – Science Media Centre

Study finds low risk of venous thromboembolism in outpatients with Covid-19 – researchers advise against the use of anticoagulants outside clinical trials

8 Apr, 2021 | 08:59h | UTC

Incidence of 30-Day Venous Thromboembolism in Adults Tested for SARS-CoV-2 Infection in an Integrated Health Care System in Northern California – JAMA Internal Medicine

Commentaries: VTE Related to SARS-CoV-2 Infection Less Of a Problem in Outpatients – TCTMD AND No Increase Seen in Outpatient VTE for SARS-CoV-2-Positive Patients – Physician’s Weekly

Commentary on Twitter (thread – Click for more)

Interesting report on VTE incidence in COVID-19 patients, starting with counting outside of the hospital. See https://t.co/XJvbrfHm6d … 1/n

— Geert-Jan Geersing (@gjgeersing) April 7, 2021

Guidance on syndrome of Thrombosis and Thrombocytopenia occurring after coronavirus Vaccination

7 Apr, 2021 | 01:48h | UTC

Guidance produced from the Expert Haematology Panel (EHP) focussed on syndrome of Thrombosis and Thrombocytopenia occurring after coronavirus Vaccination – British Society of Haematology

Commentary on Twitter

*CLINICIANS*
New guidance for suspected cases of thrombosis-thrombocytopaenia syndrome following COVID-19 vaccination. This is a very rare event but worth bookmarking as it also guides you on what is NOT likely to be a case.

MT @Maherjane https://t.co/PHjFlB079y

— Trisha Greenhalgh 😷 #CovidIsAirborne (@trishgreenhalgh) April 6, 2021

Large study showed no association between blood group types and increased risk of Covid-19

7 Apr, 2021 | 01:41h | UTC

Association of Sociodemographic Factors and Blood Group Type With Risk of COVID-19 in a US Population – JAMA Network Open

Commentary on Twitter

This case-control study found blood type A was not associated with higher nor type O with lower COVID-19 susceptibility or severity. Blood types were not prognostically useful. https://t.co/P8VpvQWuwE

— JAMA Network Open (@JAMANetworkOpen) April 6, 2021

Recent progress in the treatment of cancer in children

5 Apr, 2021 | 01:15h | UTC

Recent progress in the treatment of cancer in children – CA: A Cancer Journal for Clinicians

Cohort Study: DOACs Safe, Effective in Subset of Valvular AF Patients

5 Apr, 2021 | 01:10h | UTC

DOACs Safe, Effective in Subset of Valvular AF Patients – TCTMD

Original study: Effectiveness and Safety of Direct Oral Anticoagulants Versus Warfarin in Patients With Valvular Atrial Fibrillation: A Population-Based Cohort Study – Annals of Internal Medicine

Cohort study: High thrombotic risk in cancer patients receiving immunotherapy

5 Apr, 2021 | 01:08h | UTC

High thrombotic risk in cancer patients receiving immunotherapy – Medical University of Vienna

Original study: Incidence, risk factors, and outcomes of venous and arterial thromboembolism in immune checkpoint inhibitor therapy – Blood

Exceedingly rare side effects reported with AstraZeneca vaccine in the UK – 22 cases of cerebral venous sinus thrombosis with low levels of platelets out of 18 million vaccinated individuals

5 Apr, 2021 | 01:45h | UTC

Covid-19: Seven UK blood clot deaths after AstraZeneca vaccine – BBC

Original report: Coronavirus vaccine – weekly summary of Yellow Card reporting – Medicines and Healthcare products Regulatory Agency

“Based on current experience, the expected benefits of both COVID-19 vaccines in preventing COVID-19 and its serious complications far outweigh any known side effects”