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Hematology

RECOVERY trial: No Benefit from convalescent plasma in hospitalized patients with Covid-19

17 Jan, 2021 | 22:26h | UTC

RECOVERY trial closes recruitment to convalescent plasma treatment for patients hospitalised with COVID-19

Commentary: Covid: ‘Convalescent plasma no benefit to hospital patients’ – BBC

 


Observational study: Among patients hospitalized with Covid-19 not receiving mechanical ventilation, transfusion of plasma with higher anti–SARS-CoV-2 IgG antibody levels is linked to lower risk of death than transfusion of plasma with lower antibody levels

15 Jan, 2021 | 08:59h | UTC

Convalescent Plasma Antibody Levels and the Risk of Death from Covid-19 – New England Journal of Medicine

Editorial: (A Little) Clarity on Convalescent Plasma for Covid-19 – New England Journal of Medicine

Commentaries: Expert reaction to study looking at convalescent plasma antibody levels and risk of death from COVID-19 – Science Media Centre AND Antibody-rich convalescent plasma may lower risk of COVID death – CIDRAP

 


Opinion: RCTs don’t justify using convalescent plasma or antibody cocktails

15 Jan, 2021 | 08:58h | UTC

RCTs don’t justify using convalescent plasma or antibody cocktails – PulmCrit

 


Randomized trial: Once-per-week selinexor, bortezomib, and dexamethasone versus twice-per-week bortezomib and dexamethasone in patients with multiple myeloma

15 Jan, 2021 | 08:12h | UTC

Once-per-week selinexor, bortezomib, and dexamethasone versus twice-per-week bortezomib and dexamethasone in patients with multiple myeloma (BOSTON): a randomised, open-label, phase 3 trial – The Lancet (link to abstract – $ for full-text)

Commentary: Triplet therapy slows refractory multiple myeloma – MedicalXpress

 


Systematic review: Primary prophylaxis for venous thromboembolism in ambulatory cancer patients receiving chemotherapy

13 Jan, 2021 | 01:37h | UTC

Primary prophylaxis for venous thromboembolism in ambulatory cancer patients receiving chemotherapy – Cochrane Library

Summary: Prevention of blood clots in non-hospitalised cancer patients receiving chemotherapy – Cochrane Library

 


Blood plasma treatment has limited effect for sickest COVID-19 patients

12 Jan, 2021 | 02:07h | UTC

Blood plasma treatment has limited effect for sickest COVID-19 patients – Imperial College London

See also: Expert reaction to REMAP-CAP recruitment of severely ill COVID-19 patients into convalescent plasma trial being paused after initial analysis suggested it did not improve outcomes – Science Media Centre AND Trial of COVID-19 blood plasma finds no benefit in severely ill patients – Reuters

 


Randomized trial: Plasma therapy administered early is beneficial in high-risk elderly patients

12 Jan, 2021 | 02:05h | UTC

Early High-Titer Plasma Therapy to Prevent Severe Covid-19 in Older Adults – New England Journal of Medicine

Commentaries: Early convalescent plasma may lower risk of severe COVID in seniors – CIDRAP AND Covid-19: Early Plasma Treatment Improved Outcomes in Older Patients – Physician’s Weekly

 

Commentaries on Twitter

 


ACC Consensus: Anticoagulation and antiplatelet therapy in patients with atrial fibrillation or venous thromboembolism undergoing PCI or with atherosclerotic cardiovascular disease

12 Jan, 2021 | 01:50h | UTC

2020 ACC Expert Consensus Decision Pathway for Anticoagulant and Antiplatelet Therapy in Patients With Atrial Fibrillation or Venous Thromboembolism Undergoing Percutaneous Coronary Intervention or With Atherosclerotic Cardiovascular Disease: A Report of the American College of Cardiology Solution Set Oversight Committee – Journal of the American College of Cardiology

Commentaries: ACC Issues New Guidance Around Antithrombotic Choices in A-fib, VTE – TCTMD AND ACC Issues Clinical Guidance For Antithrombotic Therapy in Patients With AFib or VTE Undergoing PCI or With ASCVD – American College of Cardiology

 

Commentary on Twitter

 


[Press release – results not published yet] International trials of blood thinners in critically ill COVID-19 patients pause due to futility

10 Jan, 2021 | 20:44h | UTC

International trials of blood thinners in critically ill COVID-19 patients pause due to futility – NIH News Releases

 

Commentary on Twitter

 


Randomized trial: In extremely-low-birth-weight infants, a higher hemoglobin threshold for red-cell transfusion does not improve outcomes

10 Jan, 2021 | 20:36h | UTC

Higher or Lower Hemoglobin Transfusion Thresholds for Preterm Infants – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Higher red cell transfusion threshold offers no advantage for treating preterm infants – NIH News Releases

 


Case series: Shedding of viable SARS-CoV-2 after immunosuppressive therapy for cancer

2 Dec, 2020 | 07:31h | UTC

Shedding of Viable SARS-CoV-2 after Immunosuppressive Therapy for Cancer – New England Journal of Medicine

 


NICE COVID-19 guideline: Prevention of thromboembolism in patients with COVID-19. “For patients who are having advanced respiratory support: consider increasing pharmacological VTE prophylaxis to an intermediate dose”

1 Dec, 2020 | 08:19h | UTC

COVID-19 rapid guideline: reducing the risk of venous thromboembolism in over 16s with COVID-19 – National Institute for Health and Care Excellence

 


Randomized trial: Intravenous iron is superior to oral iron for the treatment of anemia in women after childbirth in a low-income setting

27 Nov, 2020 | 08:41h | UTC

Efficacy and safety of intravenous ferric carboxymaltose compared with oral iron for the treatment of iron deficiency anaemia in women after childbirth in Tanzania: a parallel-group, open-label, randomised controlled phase 3 trial – The Lancet Global Health

Commentary: Iron infusion highly effective to treat anemia in low-income settings – Swiss Tropical and Public Health Institute / News Medical

 

Commentary on Twitter

 


Randomized trial: Convalescent Plasma does not improve clinical status or overall mortality in severe Covid-19 pneumonia

25 Nov, 2020 | 09:17h | UTC

A Randomized Trial of Convalescent Plasma in Covid-19 Severe Pneumonia – New England Journal of Medicine

Commentary: New trial of convalescent plasma for covid-19 falls flat, another setback for hyped treatment – Brief19

 

Commentary on Twitter

 


Diagnosis, management, and pathophysiology of arterial and venous thrombosis in COVID-19

24 Nov, 2020 | 09:34h | UTC

Diagnosis, Management, and Pathophysiology of Arterial and Venous Thrombosis in COVID-19 – JAMA

 

Commentary on Twitter

 


Treatment of community-acquired pneumonia in immunocompromised adults: A consensus statement regarding initial strategies

17 Nov, 2020 | 09:40h | UTC

Treatment of Community-Acquired Pneumonia in Immunocompromised Adults: A Consensus Statement Regarding Initial Strategies – CHEST

Editorial: Management of Community-Acquired Pneumonia in Immunocompromised Adults – CHEST

 


#AHA20 – In patients hospitalized for heart failure with iron deficiency, intravenous Ferric carboxymaltose at discharge reduced the risk of heart failure rehospitalizations

16 Nov, 2020 | 01:53h | UTC

Ferric carboxymaltose for iron deficiency at discharge after acute heart failure: a multicentre, double-blind, randomised, controlled trial – The Lancet

Commentaries: Intravenous iron reduced rehospitalization risk in people with heart failure – American Heart Association AND AFFIRM-AHF: IV Iron Supplementation Linked to Fewer Repeat Hospitalizations for HF – TCTMD

 

Commentary on Twitter

 


Review: Diagnosis and treatment of lower extremity venous thromboembolism. Role of pretest probability and D-Dimer on diagnosis + treatment issues such as postthrombotic syndrome and the role of new anticoagulants

5 Nov, 2020 | 09:00h | UTC

Diagnosis and Treatment of Lower Extremity Venous Thromboembolism: A Review – JAMA (free for a limited period)

Summary: Diagnosis and Treatment of Lower Extremity Venous Thromboembolism – American College of Cardiology

 


Randomized trial: Vitamin C does not improve iron absorption in adult patients with iron deficiency anemia

4 Nov, 2020 | 09:42h | UTC

The Efficacy and Safety of Vitamin C for Iron Supplementation in Adult Patients With Iron Deficiency Anemia: A Randomized Clinical Trial – JAMA Network Open

Commentary: Study: Vitamin C Supplements Have No Effect on Iron-Deficiency Anemia – NEJM Journal Watch

 

Commentary on Twitter

 


Systematic review: Antithrombotic drugs for people with antiphospholipid syndrome

28 Oct, 2020 | 08:50h | UTC

Antiplatelet and anticoagulant agents for secondary prevention of stroke and other thromboembolic events in people with antiphospholipid syndrome – Cochrane Library

Summary: Anticoagulant drugs or antiplatelet drugs, or both, for reducing the risk of blood clots and stroke in people with antiphospholipid syndrome – Cochrane Library

 


Randomized trial: Convalescent plasma ineffective for patients hospitalized with Covid-19

23 Oct, 2020 | 09:15h | UTC

Convalescent plasma in the management of moderate covid-19 in adults in India: open label phase II multicentre randomised controlled trial (PLACID Trial) – The BMJ

Editorial: Convalescent plasma is ineffective for covid-19 – The BMJ

 

Commentary on Twitter

 


Pro/con debate: Therapeutic anticoagulation in hospitalized patients with Covid-19 without established thromboembolism

23 Oct, 2020 | 09:12h | UTC

Anticoagulation in Hospitalized Patients with Covid-19 – New England Journal of Medicine

Related editorial: Anticoagulation in COVID-19: It Is Time for High-Quality Evidence – Journal of the American College of Cardiology

 


Podcast: Deep vein thrombosis and pulmonary embolism

23 Oct, 2020 | 08:58h | UTC

#238 DVT / PE Triple Distilled – The Curbsiders Internal Medicine Podcast

 


Position Statement: Standardizing care to manage bleeding disorders in adolescents with heavy menses

21 Oct, 2020 | 09:07h | UTC

Standardizing care to manage bleeding disorders in adolescents with heavy menses—A joint project from the ISTH pediatric/neonatal and women’s health SSCs – Journal of Thrombosis and Haemostasis

 


Meta-analysis: The association of D-dimers with mortality, intensive care unit admission or ARDS in patients hospitalized with COVID-19

20 Oct, 2020 | 01:37h | UTC

The association of D-dimers with mortality, intensive care unit admission or acute respiratory distress syndrome in patients hospitalized with coronavirus disease 2019 (COVID-19): a systematic review and meta-analysis – Heart & Lung

 


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