Rheumatology
RCT | Effect of Tocilizumab on disease activity in patients with active polymyalgia rheumatica receiving glucocorticoid therapy.
22 Sep, 2022 | 13:06h | UTCEffect of Tocilizumab on Disease Activity in Patients With Active Polymyalgia Rheumatica Receiving Glucocorticoid Therapy: A Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Tocilizumab as a Novel Therapy for Steroid-Dependent Polymyalgia Rheumatica – JAMA (free for a limited period)
Video Editor’s Note: Tocilizumab and Disease Activity in Patients With Polymyalgia Rheumatica Receiving Glucocorticoid Therapy – JAMA
RCTs | Effect of Roflumilast cream vs. vehicle cream on chronic plaque psoriasis.
22 Sep, 2022 | 13:06h | UTCEffect of Roflumilast Cream vs Vehicle Cream on Chronic Plaque Psoriasis: The DERMIS-1 and DERMIS-2 Randomized Clinical Trials – JAMA (free for a limited period)
Editorial: Roflumilast for Chronic Plaque Psoriasis – JAMA
Commentary: Study Suggests Roflumilast May Be Effective As Treatment For Plaque Psoriasis – HCPLive
Commentary on Twitter
Roflumilast cream resulted in better chronic plaque psoriasis clinical status compared with vehicle cream at 8 weeks; further research is needed to compare efficacy with other active treatments and to assess longer-term efficacy and safety. https://t.co/DyGNNjr5ea #Research pic.twitter.com/QnMcChnht6
— JAMA (@JAMA_current) September 21, 2022
RCT | Deucravacitinib vs. placebo and Apremilast in moderate to severe plaque psoriasis.
20 Sep, 2022 | 13:16h | UTC
RCT | Methotrexate may increase response rates in patients with uncontrolled gout receiving Pegloticase.
19 Sep, 2022 | 12:38h | UTCCommentary: Data Now Out for Pegloticase-MTX Combo Gout Treatment – MedPage Today (free registration required)
RCT | Olokizumab, a monoclonal antibody against interleukin-6, in combination with methotrexate in patients with rheumatoid arthritis inadequately controlled by tumor necrosis factor inhibitor therapy.
19 Sep, 2022 | 12:35h | UTC
Study finds a higher complication rate after acute coronary syndrome in patients with rheumatic immune‐mediated inflammatory diseases.
15 Sep, 2022 | 13:01h | UTCNews Release: Study finds higher complication rate after heart attack in people with autoimmune disease – American Heart Association
M-A of randomized trials | Digital health interventions for musculoskeletal pain conditions.
14 Sep, 2022 | 13:08h | UTC
Phase 2 RCT | Safety, tolerability, and efficacy of pirfenidone in patients with rheumatoid arthritis-associated interstitial lung disease.
6 Sep, 2022 | 14:22h | UTC
Commentary on Twitter
NEW Research—Pirfenidone slowed the rate of decline of FVC over time in patients with RA-ILD*
Being presented at #ERSCongress, ALERT 3 session, Sept 5 from 13:15 BST
From Joshua Solomon & colleagues https://t.co/Nu8wECECdD
*(please check study limitations) pic.twitter.com/IuRxLDZGd9
— The Lancet Respiratory Medicine (@LancetRespirMed) September 5, 2022
RCT | In patients with rheumatoid arthritis, Tofacitinib is associated with increased risk of infections compared to TNF inhibitors.
1 Sep, 2022 | 11:50h | UTC
Commentary on Twitter
Check out our latest paper on infections in #rheumatoid #arthritis patients from the ORAL Surveillance trial:
▶️ tofacitinib lead to higher infection rates (serious and non-serious) vs TNFi
▶️ increased rates more pronounced in patients aged > 65🔗 https://t.co/3pVrnzzFWD pic.twitter.com/Kf7p6D0jBD
— ARD & RMD Open (@ARD_BMJ) August 11, 2022
#ESCCongress | Effect of statin therapy on muscle symptoms: an individual participant data meta-analysis of large-scale, randomized, double-blind trials.
30 Aug, 2022 | 12:16h | UTCNews Release: Cardiovascular protection from statins greatly outweighs the risk of muscle symptoms – European Society of Cardiology
Commentary: Only Very Small Risk of Muscle Symptoms With Statins: CTT Collaboration – TCTMD
[News release – not published yet] #ESCCongress – RCT | Allopurinol does not improve cardiovascular outcomes in ischemic heart disease patients.
29 Aug, 2022 | 12:15h | UTCCommentary:
ALL-HEART: Gout Drug Allopurinol No Help in CV Prevention – TCTMD
No improvement with allopurinol for patients with ischemic heart disease: ALL-HEART – Cardiology Now
Autoimmune diseases and cardiovascular risk: a population-based study on 19 autoimmune diseases and 12 cardiovascular diseases in 22 million individuals in the UK.
29 Aug, 2022 | 12:11h | UTCAutoimmune diseases and cardiovascular risk: a population-based study on 19 autoimmune diseases and 12 cardiovascular diseases in 22 million individuals in the UK – The Lancet (free registration required)
Commentary: Population-based study: Autoimmune disorders increase risk of cardiovascular disease – MedicalXpress
RCT | Upadacitinib for the treatment of active non-radiographic axial spondyloarthritis.
29 Aug, 2022 | 11:58h | UTCUpadacitinib for the treatment of active non-radiographic axial spondyloarthritis (SELECT-AXIS 2): a randomised, double-blind, placebo-controlled, phase 3 trial – The Lancet (link to abstract – $ for full-text)
RCT | Olokizumab vs. Placebo or Adalimumab in rheumatoid arthritis.
25 Aug, 2022 | 12:04h | UTCOlokizumab versus Placebo or Adalimumab in Rheumatoid Arthritis – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Novel IL-6 Blocker Matches Humira in Rheumatoid Arthritis – MedPage Today (free registration required)
Observational study suggests Hydroxychloroquine is associated with increased risk of cardiovascular events compared to Methotrexate in patients with heart failure.
25 Aug, 2022 | 11:56h | UTCCardiovascular Risks of Hydroxychloroquine vs Methotrexate in Patients With Rheumatoid Arthritis – Journal of the American College of Cardiology (link to abstract – $ for full-text)
Editorial: Hydroxychloroquine: Heart-Throb No More? – Journal of the American College of Cardiology
Commentary: Caution needed with hydroxychloroquine use in older RA patients with heart failure – medwire News
Systematic Review | Therapeutic drug monitoring of biopharmaceuticals in inflammatory rheumatic and musculoskeletal disease.
25 Aug, 2022 | 11:55h | UTC
Management of hand osteoarthritis: from an US evidence-based medicine guideline to a European patient-centric approach.
24 Aug, 2022 | 14:09h | UTCRelated:
Erosive hand osteoarthritis: latest findings and outlook – Nature Reviews Rheumatology
ACR Guideline for the Management of Osteoarthritis of the Hand, Hip, and Knee
Research: Hydroxychloroquine Effectiveness in Reducing Symptoms of Hand Osteoarthritis
Podcast | Myositis and myopathy.
24 Aug, 2022 | 14:04h | UTC#348 Myositis and Myopathy, LIVE! – The Curbsiders
Systematic Review | There is insufficient evidence to recommend running shoes for preventing lower limb running injuries in adults.
23 Aug, 2022 | 13:00h | UTCRunning shoes for preventing lower limb running injuries in adults – Cochrane Library
Summary: Running shoes for preventing lower-limb running injuries in adults – Cochrane Library
Commentary on Twitter
👟Running shoes have been proposed as one means of reducing injury risk….but are they effective? @CochraneBJMT authors looked at 12 trials that lasted 6-26 wks with 11,240 people. https://t.co/09bt9SzEkh pic.twitter.com/qi5qk7W1I1
— The Cochrane Library (@CochraneLibrary) August 22, 2022
Consensus Statement | Preoperative management of medications for rheumatologic and HIV diseases.
22 Aug, 2022 | 12:22h | UTCRelated:
Preoperative Management of Medications for Neurologic Diseases – Mayo Clinic Proceedings
Preoperative Management of Surgical Patients Using Dietary Supplements – Mayo Clinic Proceedings
Perioperative Evaluation and Management of Endocrine Disorders – Mayo Clinic Proceedings
Preoperative Cardiac Risk Assessment – Mayo Clinic Proceedings
Preoperative Evaluation Before Noncardiac Surgery – Mayo Clinic Proceedings
Perioperative Cardiac Risk Reduction in Noncardiac Surgery – Mayo Clinic Proceedings
Perioperative Venous Thromboembolism Prophylaxis – Mayo Clinic Proceedings
RCT | Surgical reconstruction is superior to rehabilitation for patients with non-acute anterior cruciate ligament injury with persistent symptoms of instability.
22 Aug, 2022 | 12:16h | UTC
Commentary on Twitter
Surgical reconstruction of non-acute ACL injury with persistent symptoms of instability was superior in comparison with rehabilitation at 18 months (KOOS4 mean difference 7.9 (95% CI 2.5–13.2)): https://t.co/y2taBzHolU pic.twitter.com/n0qW3B6cMv
— Søren T. Skou (@STSkou) August 19, 2022
Under a Creative Commons Attribution (CC BY 4.0) license
Review | Systemic lupus erythematosus and cardiovascular disease.
22 Aug, 2022 | 12:02h | UTCSystemic lupus erythematosus and cardiovascular disease – Journal of Internal Medicine
M-A | Efficacy of corticosteroids for hand osteoarthritis.
19 Aug, 2022 | 16:03h | UTC
Review | Autoimmune/autoinflammatory syndrome induced by adjuvants: a focus on silicone.
18 Aug, 2022 | 12:34h | UTC
Commentary on Twitter
🔥Check out a NEW review on #autoimmune/autoinflammatory syndrome induced by #adjuvants (ASIA): a focus on #silicone
👉https://t.co/ctLoUi79KN pic.twitter.com/BZCpp7iM8t— ClinRheumatol (@ClinRheumatol) August 17, 2022
Cohort Study | Racial and sex disparities in gout prevalence among adults.
16 Aug, 2022 | 13:30h | UTCRacial and Sex Disparities in Gout Prevalence Among US Adults – JAMA Network Open
Commentary: Once the ‘Disease of Kings,’ Gout Now Reigns Through Poverty, Disparity – MedPage Today (free registration required)