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Rheumatology

Guideline for the diagnosis and management of eosinophilic granulomatosis with polyangiitis

24 May, 2023 | 13:16h | UTC

Evidence-Based Guideline for the diagnosis and management of eosinophilic granulomatosis with polyangiitis – Nature Reviews Rheumatology (if the link is paywalled, try this one)

Related: 2022 ACR/EULAR Classification Criteria for Eosinophilic Granulomatosis with Polyangiitis.

 

Commentary on Twitter

 

Review | Update in musculoskeletal pain in older adults with a focus on osteoarthritis-related pain

24 May, 2023 | 13:09h | UTC

Clin-STAR corner: 2021 update in musculoskeletal pain in older adults with a focus on osteoarthritis-related pain – Journal of the American Geriatrics Society

 

Phase 2 RCT | Peresolimab outperforms placebo in patients with moderate-to-severe rheumatoid arthritis

24 May, 2023 | 13:07h | UTC

A Phase 2 Trial of Peresolimab for Adults with Rheumatoid Arthritis – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Peresolimab Demonstrates Efficacy in Treating Patients With Rheumatoid Arthritis – HCP Live

 

Commentary on Twitter

 

M-A | Limited evidence for safety and effectiveness of most antidepressants in chronic pain management

18 May, 2023 | 13:50h | UTC

Antidepressants for pain management in adults with chronic pain: a network meta‐analysis – Cochrane Library

News Release: Most antidepressants prescribed for chronic pain lack reliable evidence of efficacy or safety, scientists warn – Cochrane Library

Summary: How effective are antidepressants used to treat chronic pain and do they cause unwanted effects? – Cochrane Library

Commentary: Expert reaction to Cochrane review on antidepressants for pain management in adults with chronic pain – Science Media Centre

 

Cohort Study | Patients with joint hypermobility at greater risk of second ACL injury post-surgery within a year of return to sport

18 May, 2023 | 13:33h | UTC

Generalised joint hypermobility leads to increased odds of sustaining a second ACL injury within 12 months of return to sport after ACL reconstruction – British Journal of Sports Medicine

RCT | Colchicine ineffective for pain relief in hand osteoarthritis patients

16 May, 2023 | 14:42h | UTC

Colchicine twice a day for hand osteoarthritis (COLOR): a double-blind, randomised, placebo-controlled trial – The Lancet Rheumatology (link to abstract – $ for full-text)

Commentary: Colchicine Does Not Relieve OA-Related Hand Pain Compared With Placebo – DocWireNews

 

Commentary on Twitter

 

Canadian Task Force advises fragility fracture screening for women over 65, but not for men or younger women

15 May, 2023 | 13:23h | UTC

Recommendations on screening for primary prevention of fragility fractures – Canadian Medical Association Journal

Related USPSTF Statement: Screening Osteoporosis to Prevent Fractures

 

Therapeutic plasma exchange: Core curriculum 2023

15 May, 2023 | 13:14h | UTC

Therapeutic Plasma Exchange: Core Curriculum 2023 – American Journal of Kidney Diseases

 

Commentary on Twitter

 

Cutaneous Lupus Erythematosus | An update on pathogenesis and future therapeutic directions

12 May, 2023 | 13:28h | UTC

Cutaneous Lupus Erythematosus: An Update on Pathogenesis and Future Therapeutic Directions – American Journal of Clinical Dermatology

 

M-A | Surgical interventions for symptomatic knee osteoarthritis

12 May, 2023 | 13:26h | UTC

Surgical interventions for symptomatic knee osteoarthritis: a network meta-analysis of randomized control trials – BMC Musculoskeletal Disorders

 

RCT | Cognitive functional therapy with or without biofeedback outperforms usual care for chronic low back pain relief

10 May, 2023 | 15:58h | UTC

Cognitive functional therapy with or without movement sensor biofeedback versus usual care for chronic, disabling low back pain (RESTORE): a randomised, controlled, three-arm, parallel group, phase 3, clinical trial – The Lancet (link to abstract – $ for full-text)

News Release: Fresh hope for Australians living with chronic back pain – Curtin University

 

Proposal of a new diagnostic algorithm for adult-onset Still’s disease

9 May, 2023 | 14:41h | UTC

Proposal of a new diagnostic algorithm for adult-onset Still’s disease – Clinical Rheumatology

 

Commentary on Twitter

 

Cohort Study | Autoimmune disorders’ incidence, prevalence & co-occurrence by age, sex, and socioeconomic status

8 May, 2023 | 13:14h | UTC

Incidence, prevalence, and co-occurrence of autoimmune disorders over time and by age, sex, and socioeconomic status: a population-based cohort study of 22 million individuals in the UK – The Lancet (free for a limited period)

 

Commentary from the author on Twitter (thread – click for more)

 

SR | What Is the efficacy of intra-articular injections in the treatment of ankle osteoarthritis

8 May, 2023 | 12:48h | UTC

What Is the Efficacy of Intra-articular Injections in the Treatment of Ankle Osteoarthritis? A Systematic Review – Clinical Orthopaedics and Related Research

 

Treating long-lasting low back pain without surgery: the latest evidence

4 May, 2023 | 13:40h | UTC

Treating long-lasting low back pain without surgery: the latest evidence – Evidently Cochrane

 

M-A | Efficacy of osteoporosis interventions on fracture prevention in postmenopausal women

3 May, 2023 | 15:37h | UTC

Fracture risk reduction and safety by osteoporosis treatment compared with placebo or active comparator in postmenopausal women: systematic review, network meta-analysis, and meta-regression analysis of randomised clinical trials – The BMJ

 

Guideline | Management of systemic lupus erythematosus

12 Apr, 2023 | 13:16h | UTC

Egyptian recommendations for the management of systemic lupus erythematosus: a consensus, evidence-based, clinical practice guidelines for treat-to-target management – Egyptian Rheumatology and Rehabilitation

 

Pharmacological treatments for low back pain in adults: an overview of Cochrane Reviews

11 Apr, 2023 | 14:39h | UTC

Pharmacological treatments for low back pain in adults: an overview of Cochrane Reviews – Cochrane Database of Systematic Reviews

Summary: Pharmacological treatments for low back pain in adults: an overview of Cochrane Reviews – Cochrane Database of Systematic Reviews

Related:

SR | Nonopioid pharmacological management of acute low back pain

M-A | Limited evidence for analgesic effectiveness in acute low back pain treatment

Chronic Low Back Pain: A Narrative Review of Recent International Guidelines for Diagnosis and Conservative Treatment – Journal of Clinical Medicine

M-A: Effectiveness of treatments for acute and subacute mechanical non-specific low back pain

Guideline Interventions for the management of acute and chronic low back pain.

M-A: Little benefit from muscle relaxants for adults with non-specific low back pain.

 

Podcast | Childhood-Onset SLE

6 Apr, 2023 | 13:12h | UTC

#77: Childhood-Onset SLE – Is It Sometimes Lupus? – The Cribsiders

 

RCT | No significant fracture reduction from monthly 60,000 IU vitamin D3 supplementation

4 Apr, 2023 | 13:58h | UTC

The effect of monthly vitamin D supplementation on fractures: a tertiary outcome from the population-based, double-blind, randomised, placebo-controlled D-Health trial – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)

Related:

SR | Calcium and vitamin D supplements do not increase bone mineral density or prevent fractures in premenopausal women

RCT | Supplemental Vitamin D does not reduce incident fractures in midlife and older adults.

Comparison of fracture risk using different supplemental doses of vitamin D, calcium or their combination: a network meta-analysis of randomised controlled trials – BMJ Open

Association Between Calcium or Vitamin D Supplementation and Fracture Incidence in Community-Dwelling Older Adults: A Systematic Review and Meta-analysis – JAMA

 

RCT | Vitamin D supplementation shows no significant impact on psoriasis severity

4 Apr, 2023 | 13:51h | UTC

Summary: In a randomized, double-blind, placebo-controlled clinical trial involving 122 participants with plaque psoriasis, researchers investigated the effects of vitamin D supplementation on psoriasis severity during winter. Participants received either vitamin D (cholecalciferol, 100,000 IU loading dose followed by 20,000 IU/week) or a placebo for four months. The primary outcome was Psoriasis Area Severity Index (PASI) scores, with secondary outcomes including Physician Global Assessment, self-administered PASI, and Dermatology Life Quality Index scores.

The study found no significant difference in PASI scores or secondary outcomes between the two groups. The results suggest that vitamin D supplementation does not affect psoriasis severity. However, low baseline severity scores and a lower than expected increase in 25-hydroxyvitamin D levels in the intervention group may have influenced the findings, indicating that further research may be needed to account for these factors.

Article: Effect of Vitamin D Supplementation on Psoriasis Severity in Patients With Lower-Range Serum 25-Hydroxyvitamin D Levels: A Randomized Clinical Trial – JAMA Dermatology (free for a limited period)

Commentary: Vitamin D Ineffective for Psoriasis Patients with Lower Serum 25-Hydroxyvitamin D Levels in Winter – HCP Live

 

Commentary on Twitter

 

2ry analysis of a RCT | Vitamin D supplementation does not affect cognitive function in older adults

30 Mar, 2023 | 14:14h | UTC

Vitamin D supplementation and cognition—Results from analyses of the D-Health trial – Journal of the American Geriatrics Society (link to abstract – $ for full-text)

Original Study: RCT: Oral Vitamin D supplementation (60.000 IU per month) did not reduce mortality in patients 60 years or older (unscreened individuals in Australia, many without insufficiency, average 30ng/mL). Exploratory analyses pointed towards an increased risk of death from cancer.

Related:

Randomized Trial: Vitamin D Supplements and Prevention of Cancer and Cardiovascular Disease

Meta-Analysis: Vitamin D Not Effective for Cardiovascular Disease Prevention

Association between vitamin D supplementation and mortality: systematic review and meta-analysis – The BMJ

USPSTF Draft Statement: Insufficient evidence to recommend multivitamin supplements for the prevention of CVD or cancer. The statement also recommends against the use of beta-carotene (increases risk of CVD mortality and lung cancer) or vitamin E (clear evidence of no benefit)

Vitamin D, calcium, other vitamins, and supplements do not prevent cardiovascular diseases

Research: Circulating vitamin D concentration and risk of seven cancers

Research: Vitamin D and risk of total and site specific cancers

 

RCT | Hydroxychloroquine in children with proliferative lupus nephritis

30 Mar, 2023 | 14:11h | UTC

Hydroxychloroquine in children with proliferative lupus nephritis: a randomized clinical trial – European Journal of Pediatrics

 

SR | Extracutaneous features and complications of the Ehlers-Danlos syndromes

30 Mar, 2023 | 13:41h | UTC

Extracutaneous features and complications of the Ehlers-Danlos syndromes: A systematic review – Frontiers in Medicine

 

M-A | Limited evidence for analgesic effectiveness in acute low back pain treatment

29 Mar, 2023 | 13:32h | UTC

Summary: The objective of this systematic review and network meta-analysis was to assess the effectiveness and safety of various analgesic medicines for treating acute non-specific low back pain. After examining 98 randomized controlled trials with over 15,000 participants, the study found that the quality of evidence for the effectiveness and safety of these medications is low or very low.

Some analgesic medicines showed potential in reducing pain intensity, but the evidence was limited due to trial risk of bias and imprecision in effect estimates. Furthermore, certain medications might increase the risk of adverse events during treatment, with evidence ranging from moderate to very low confidence.

Given the lack of high-quality evidence, clinicians and patients are advised to be cautious when using analgesic medicines for acute non-specific low back pain. More robust head-to-head comparison trials are needed to provide clearer guidance on the best course of treatment.

Article: Comparative effectiveness and safety of analgesic medicines for adults with acute non-specific low back pain: systematic review and network meta-analysis – The BMJ

News Release: Study finds “considerable uncertainty” around effectiveness and safety of analgesics for low back pain – BMJ Newsroom

 

Commentary from the author on Twitter (thread – click for more)

 

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