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Vaccines

WHO updated roadmap for prioritizing uses of COVID-19 vaccines.

24 Jan, 2022 | 08:49h | UTC

WHO SAGE Roadmap for prioritizing uses of COVID-19 vaccines – World Health Organization

Commentary: WHO: COVID boosters should start with most vulnerable – Associated Press

 

Commentary on Twitter (thread – click for more)

 


RCT: Immunogenicity and reactogenicity of different vaccine boosters after a first J&J vaccine.

21 Jan, 2022 | 10:12h | UTC

Immunogenicity and Reactogenicity of Vaccine Boosters after Ad26.COV2.S Priming – New England Journal of Medicine

 

Commentary on Twitter

 


WHO’s Emergencies expert group re-asserts stance against covid ‘vaccine passports’ for international travel.

21 Jan, 2022 | 10:02h | UTC

WHO’s Emergencies Expert Group Re-Asserts Stance Against COVID ‘Vaccine Passports’ for International Travel – Health Policy Watch

 


A populational-based retrospective cohort study in Qatar showed a reduced risk of Covid-19 breakthrough infections with the Moderna vs. the Pfizer–BioNTech vaccine.

20 Jan, 2022 | 09:30h | UTC

Effectiveness of mRNA-1273 and BNT162b2 Vaccines in Qatar – New England Journal of Medicine

 

Commentary on Twitter

 


Placebo effect accounts for more than two-thirds of COVID-19 vaccine adverse events, researchers find.

19 Jan, 2022 | 08:53h | UTC

News Release: Placebo effect accounts for more than two-thirds of COVID-19 vaccine adverse events, researchers find – Beth Israel Deaconess Medical Center

Original Study: Frequency of Adverse Events in the Placebo Arms of COVID-19 Vaccine Trials: A Systematic Review and Meta-analysis – JAMA Network Open

Commentary: ‘Nocebo effect’: two-thirds of Covid jab reactions not caused by vaccine, study suggests – The Guardian

 


WHO says there’s no evidence healthy children and adolescents need Covid boosters.

19 Jan, 2022 | 08:46h | UTC

WHO says there’s no evidence healthy children and adolescents need Covid boosters – CNBC

 


[Not published yet] Study in Israel finds fourth COVID booster has limited efficacy.

18 Jan, 2022 | 09:59h | UTC

Israel Finds Fourth COVID Booster is Ineffective, While Hospitalised Omicron Patients Fare Much Better Than Delta Patients – Health Policy Watch

See also:

Israeli trial, world’s first, finds 4th dose ‘not good enough’ against Omicron – The Times of Israel

Israel study: 4th vaccine shows limited results with omicron – MedicalXpress

 


COVAX delivers one billionth COVID-19 vaccine dose – but 41% of world remains unvaccinated.

18 Jan, 2022 | 09:56h | UTC

COVAX Delivers One Billionth COVID-19 Vaccine Dose – But 41% of World Remains Unvaccinated – Health Policy Watch

See also: COVID program delivers 1 billion doses to poorer countries – Associated Press

Related:

Is Covax finally going to vaccinate the world?

How Covax failed on its promise to vaccinate the world – “Covax, described as “naively ambitious” by one expert, has contributed just 5% of all vaccines administered globally”.

Perspective | A beautiful idea: how COVAX has fallen short.

WHO Launches Strategy to Achieve Global Covid-19 Vaccination by mid-2022.

WHO special envoys: To beat Covid, there’s a simple lesson – no one’s safe until everyone’s safe.

Joint COVAX Statement on the Equal Recognition of Vaccines – COVAX urges all government authorities to recognize as fully vaccinated all people who have received COVID-19 vaccines that have been deemed safe and effective by WHO.

WHO COVAX Joint Statement: Call to action to equip COVAX to deliver 2 billion doses in 2021.

Covax: How will Covid vaccines be shared around the world?

 


Case series of Thrombosis with Thrombocytopenia Syndrome after Covid-19 vaccination in the US.

18 Jan, 2022 | 09:41h | UTC

Case Series of Thrombosis With Thrombocytopenia Syndrome After COVID-19 Vaccination—United States, December 2020 to August 2021 – Annals of Internal Medicine

Editorial: The Epidemiology of Thrombosis With Thrombocytopenia Syndrome: Analogies With Heparin-Induced Thrombocytopenia – Annals of Internal Medicine

 


Shoulder injury related to SARS-CoV-2 vaccine administration.

18 Jan, 2022 | 09:40h | UTC

Shoulder injury related to SARS-CoV-2 vaccine administration – Canadian Medical Association Journal

 


Is Covax finally going to vaccinate the world?

17 Jan, 2022 | 00:29h | UTC

Is Covax finally going to vaccinate the world? – Vox

Related:

How Covax failed on its promise to vaccinate the world – “Covax, described as “naively ambitious” by one expert, has contributed just 5% of all vaccines administered globally”.

Perspective | A beautiful idea: how COVAX has fallen short.

WHO Launches Strategy to Achieve Global Covid-19 Vaccination by mid-2022.

WHO special envoys: To beat Covid, there’s a simple lesson – no one’s safe until everyone’s safe.

Joint COVAX Statement on the Equal Recognition of Vaccines – COVAX urges all government authorities to recognize as fully vaccinated all people who have received COVID-19 vaccines that have been deemed safe and effective by WHO.

WHO COVAX Joint Statement: Call to action to equip COVAX to deliver 2 billion doses in 2021.

Covax: How will Covid vaccines be shared around the world?

 


Unvaccinated pregnant people are at higher risk for Covid complications and newborn deaths.

14 Jan, 2022 | 08:44h | UTC

Unvaccinated pregnant people are at higher risk for Covid complications and newborn deaths – STAT

Original Study: SARS-CoV-2 infection and COVID-19 vaccination rates in pregnant women in Scotland – Nature Medicine

 


COVID vaccines safely protect pregnant people: the data are in.

14 Jan, 2022 | 08:43h | UTC

COVID vaccines safely protect pregnant people: the data are in – Nature

Related:

COVID-19 vaccination in pregnancy—number needed to vaccinate to avoid harm.

A case-controlled study showed Covid-19 vaccination during early pregnancy was not associated with increased risk of first-trimester miscarriage.

Editorial: Covid-19 treatments and vaccines must be evaluated in pregnancy.

AstraZeneca vaccination not linked to reduced fertility rates and adverse birth outcomes.

Cohort study: Vaccinated pregnant patients had 90% lower risk of severe or critical Covid-19 compared with unvaccinated pregnant patients.

Two observational studies suggest spontaneous abortion is not increased following COVID-19 mRNA vaccination during pregnancy.

Study shows high effectiveness of the Pfizer mRNA COVID-19 vaccine in pregnancy.

5 Crucial Things to Know About COVID-19 Vaccines and Pregnancy.

CDC Guidance: Pregnant people should be vaccinated against COVID-19.

ACOG and SMFM Recommend COVID-19 Vaccination for Pregnant Individuals – “ACOG encourages its members to enthusiastically recommend vaccination to their patients.”

Cohort study: Pfizer/BioNTech COVID vaccine associated with 78% lower risk of Covid-19 in pregnancy.

 


Mapping the unvaccinated world – “If landmass reflected the number of unvaccinated people, this is what the world would look like”.

14 Jan, 2022 | 08:26h | UTC

Mapping the unvaccinated world – Pandemic

 


Study shows COVID-19 vaccines offer lasting protection against hospitalization and death.

13 Jan, 2022 | 09:01h | UTC

Duration of Protection against Mild and Severe Disease by Covid-19 Vaccines – New England Journal of Medicine

News Release: Study shows COVID-19 vaccines offer lasting protection – University of North Carolina at Chapel Hill

 


Observational study in adolescents showed the Pfizer-BioNTech vaccine had an overall effectiveness of 94% against hospitalization and 98% against critical Covid-19.

13 Jan, 2022 | 09:00h | UTC

Effectiveness of BNT162b2 Vaccine against Critical Covid-19 in Adolescents – New England Journal of Medicine

Editorial: Sparing of Severe Covid-19 in Vaccinated Adolescents – New England Journal of Medicine

 


An observational study in South Africa estimates the Pfizer vaccine had an effectiveness of 70% against hospitalization for Covid-19 caused by the omicron variant.

13 Jan, 2022 | 08:56h | UTC

Effectiveness of BNT162b2 Vaccine against Omicron Variant in South Africa – New England Journal of Medicine

Commentary: BNT162b2 still effective, but less so, against Omicron – HealthDay

 


RCT: A single dose of a novel adenovirus type 5 vectored SARS-CoV-2 vaccine was safe and had 57.5% efficacy against symptomatic Covid-19 and 91.7% efficacy against severe disease in adults.

13 Jan, 2022 | 08:44h | UTC

Final efficacy analysis, interim safety analysis, and immunogenicity of a single dose of recombinant novel coronavirus vaccine in adults 18 years and older: an international, multicentre, randomised, double-blinded, placebo-controlled phase 3 trial – The Lancet

Commentaries:

Efficacy of an adenovirus type 5 vectored SARS-CoV-2 vaccine – The Lancet

Phase 3 trial reports one dose of Ad5-nCoV COVID-19 vaccine is safe and effective, including against severe disease – The Lancet

 


How do death rates from COVID-19 differ between people who are vaccinated and those who are not?

12 Jan, 2022 | 09:02h | UTC

How do death rates from COVID-19 differ between people who are vaccinated and those who are not? – Our World in Data

 

Commentary from the author on Twitter

 


Cohort study: Among health care workers previously vaccinated with 2 doses of the Pfizer-BioNTech vaccine, receiving a third dose was associated with reduced risk of SARS-CoV-2 infection.

11 Jan, 2022 | 01:35h | UTC

Association of a Third Dose of BNT162b2 Vaccine With Incidence of SARS-CoV-2 Infection Among Health Care Workers in Israel – JAMA

Editorial: Booster Vaccination to Reduce SARS-CoV-2 Transmission and Infection – JAMA

 


CDC Report: COVID-19 vaccine safety in children aged 5–11 Years.

9 Jan, 2022 | 01:09h | UTC

COVID-19 Vaccine Safety in Children Aged 5–11 Years — United States, November 3–December 19, 2021 – CDC Morbidity and Mortality Weekly Report

Commentary: COVID-19 vaccine appears safe in children aged 5–11 Years – News Medical

 

Commentary on Twitter

 


[Preprint] Risk of myocarditis following sequential COVID-19 vaccinations by age and sex.

9 Jan, 2022 | 01:05h | UTC

Risk of myocarditis following sequential COVID-19 vaccinations by age and sex – medRxiv

Commentary: An evaluation of the association between COVID vaccination and myocarditis in 42 million people aged 13 or older – News Medical

Note: this study is an updated analysis of a recent study published in Nature Medicine; see below:

Risks of myocarditis, pericarditis, and cardiac arrhythmias associated with COVID-19 vaccination vs. SARS-CoV-2 infection.

 


[Preprint] Among individuals with prior SARS-CoV-2 infection in Brazil, vaccine effectiveness against hospitalization or death after vaccine series completion was 81.3% for CoronaVac, 89.9% for AstraZeneca, 57.7% for J&J, and 89.7% for Pfizer.

8 Jan, 2022 | 23:26h | UTC

Effectiveness of CoronaVac, ChAdOx1, BNT162b2 and Ad26.COV2.S among – medRxiv

 

[In Portuguese] Commentary from one of the authors on Twitter (thread – click for more)

 


WHO issues interim recommendations for heterologous COVID-19 vaccine schedules.

17 Dec, 2021 | 10:01h | UTC

Interim recommendations for heterologous COVID-19 vaccine schedules – World Health Organization

Commentary: Coronavirus: WHO gives the nod for mix-and-match vaccine schedules – South China Morning Post

 


Randomized trial with nearly 30.000 individuals showed Novavax vaccine was safe and had an overall efficacy of 90.4% against symptomatic infections.

17 Dec, 2021 | 09:54h | UTC

Efficacy and Safety of NVX-CoV2373 in Adults in the United States and Mexico – New England Journal of Medicine

Commentaries:

Novavax COVID vaccine shows 90.4% efficacy against infection – CIDRAP

Novavax COVID-19 vaccine found to be safe and effective – University of Maryland School of Medicine

Related: [Preprint] In RCT with 29,949 participants, the Novavax vaccine demonstrated high overall efficacy (>90%) for the prevention of Covid-19, and all moderate-to-severe cases occurred in placebo recipients. (several articles on the subject)

 


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