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General Hematology

Review: The hemostatic and thrombotic complications of liver disease.

23 Jul, 2021 | 10:23h | UTC

The Hemostatic and Thrombotic Complications of Liver Disease – European Journal of Haematology

 


Cohort study: Sickle cell disorders and severe COVID-19 outcomes – “Our analysis estimated a 4-fold increased risk for COVID-19–related hospitalization and a 2.6-fold increased risk for COVID-19–related death for sickle cell disease”.

21 Jul, 2021 | 10:44h | UTC

Sickle Cell Disorders and Severe COVID-19 Outcomes: A Cohort Study – Annals of Internal Medicine

 


WHO Guidance for clinical case management of thrombosis with thrombocytopenia syndrome (TTS) following vaccination to prevent coronavirus disease (COVID-19).

20 Jul, 2021 | 10:29h | UTC

Guidance for clinical case management of thrombosis with thrombocytopenia syndrome (TTS) following vaccination to prevent coronavirus disease (COVID-19) – World Health Organization

Related Guidance: AHA/ASA Guidance: Diagnosis and Management of Cerebral Venous Sinus Thrombosis with Vaccine-Induced Thrombotic Thrombocytopenia – “No heparin products in any dose should be given.” AND ISTH Interim Guidance for the Diagnosis and Treatment on Vaccine Induced Immune Thrombotic Thrombocytopenia

 


Expert opinion | Bioprosthetic valves and atrial fibrillation: Direct anticoagulants or warfarin – Until conclusive data are available for patients with rheumatic heart disease and those with mechanical valves, DOAC use is not indicated in these patients.

20 Jul, 2021 | 10:06h | UTC

Bioprosthetic valves and atrial fibrillation: Direct anticoagulants or warfarin – The Journal of Thoracic and Cardiovascular Surgery

 


Cohort study: Increased risk of long-term risk of anemia after bariatric surgery – Compared with the control group, the incidence of anemia was higher in the gastric bypass group (HR 5.05), the vertical-banded gastroplasty group (HR 2.67), and the gastric banding group (HR 2.76).

15 Jul, 2021 | 09:10h | UTC

Long-term risk of anaemia after bariatric surgery: results from the Swedish Obese Subjects study – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)

 


[Preprint] Heparin for Moderately Ill Patients with Covid-19 – “In moderately ill ward patients with Covid-19 and elevated D-dimer level, therapeutic heparin did not significantly reduce the primary outcome but decreased the odds of death at 28 days”.

12 Jul, 2021 | 03:14h | UTC

Heparin for Moderately Ill Patients with Covid-19 – medRxiv

Related: RCT: In patients hospitalized with Covid-19 with elevated D-Dimer, a full-dose anticoagulation strategy based on rivaroxaban (full-dose heparins in unstable patients) + rivaroxaban to day 30 was not better than prophylactic anticoagulation and increased bleeding risk. AND [Preprint] Practice Changing RCT: Therapeutic-dose anticoagulation with heparin (LMWH or unfractionated heparin) improves outcomes in non-critically ill patients with Covid-19 – the superiority of therapeutic-dose anticoagulation was seen in both high and low D-dimer groups. AND [Preprint] RCT: Full-dose/therapeutic anticoagulation provides no benefit in critically ill patients with Covid-19

 

Commentary on Twitter (thread – click for more)

 


Podcast | Heavy menstrual bleeding, anticoagulation & coagulopathy in menstruating patients.

9 Jul, 2021 | 09:56h | UTC

#280 Heavy Menstrual Bleeding, Anticoagulation & Coagulopathy in Menstruating Patients – The Curbsiders

 


Case series: therapeutic plasma exchange in 3 patients with vaccine-induced immune thrombotic thrombocytopenia.

8 Jul, 2021 | 09:17h | UTC

Therapeutic Plasma Exchange in Vaccine-Induced Immune Thrombotic Thrombocytopenia – New England Journal of Medicine

 

Commentary on Twitter

 


Guideline on the peri-operative management of patients with sickle cell disease.

8 Jul, 2021 | 08:46h | UTC

Guideline on the peri-operative management of patients with sickle cell disease – Anaesthesia

 


M-A: Convalescent plasma is safe but does not improve outcomes in the treatment of COVID-19.

7 Jul, 2021 | 08:52h | UTC

Systematic review and meta-analysis of randomised controlled trials testing the safety and efficacy of convalescent plasma in the treatment of coronavirus disease 2019 (COVID-19): Evidence-base for practise and implications for research – Transfusion Medicine

 


ESC Consensus: Management of antithrombotic therapy in patients undergoing transcatheter aortic valve implantation.

6 Jul, 2021 | 10:05h | UTC

Management of antithrombotic therapy in patients undergoing transcatheter aortic valve implantation: a consensus document of the ESC Working Group on Thrombosis and the European Association of Percutaneous Cardiovascular Interventions (EAPCI), in collaboration with the ESC Council on Valvular Heart Disease – European Heart Journal

 

Commentary on Twitter (thread – click for more)

 


Vaccine-induced immune thrombotic thrombocytopenia (VITT) – a novel clinico-pathological entity with heterogeneous clinical presentations.

2 Jul, 2021 | 11:39h | UTC

Vaccine-induced immune thrombotic thrombocytopenia (VITT) – a novel clinico-pathological entity with heterogeneous clinical presentations – British Journal of Haematology

Commentary: Blood clots related to AstraZeneca/Oxford vaccine can be mitigated with early detection – MedicalXpress

 


Pulmonary embolism in patients with COVID-19: incidence, risk factors, clinical characteristics, and outcome.

30 Jun, 2021 | 10:13h | UTC

Pulmonary embolism in patients with COVID-19: incidence, risk factors, clinical characteristics, and outcome – European Heart Journal

 


Case report: Thrombosis with Thrombocytopenia After the Messenger RNA–1273 Vaccine.

29 Jun, 2021 | 10:07h | UTC

Thrombosis With Thrombocytopenia After the Messenger RNA–1273 Vaccine – Annals of Internal Medicine

Commentary: Expert reaction to case report of from the U.S. of thrombosis with thrombocytopenia after the Moderna mRNA vaccine – Science Media Centre

 


EBM Analysis | Does tranexamic acid work for everything? For anything?

29 Jun, 2021 | 09:53h | UTC

Does TXA work for everything? For anything? – First10EM

 


The Risk of Allergic Reaction to SARS-CoV-2 Vaccines and Recommended Evaluation and Management: A Systematic Review, Meta-analysis, GRADE Assessment, and International Consensus Approach.

23 Jun, 2021 | 10:23h | UTC

The Risk of Allergic Reaction to SARS-CoV-2 Vaccines and Recommended Evaluation and Management: A Systematic Review, Meta-analysis, GRADE Assessment, and International Consensus Approach – The Journal of Allergy and Clinical Immunology: In Practice

 


Concerned about the latest AstraZeneca news? These 3 graphics help you make sense of the risk – “Two people in Australia have died from thrombosis with thrombocytopenia after 3.8 million doses of the AstraZeneca vaccine delivered”.

21 Jun, 2021 | 08:48h | UTC

Concerned about the latest AstraZeneca news? These 3 graphics help you make sense of the risk – The Conversation

 


Review: venous and arterial thromboembolism in patients with cancer.

16 Jun, 2021 | 08:20h | UTC

Venous and Arterial Thromboembolism in Patients With Cancer: JACCCardioOncology State-of-the-Art Review

Summary: Venous and Arterial Thromboembolism in Patients With Cancer – American College of Cardiology

 


RCT: In patients with atrial fibrillation or mechanical heart valves treated with warfarin undergoing surgery, postoperative bridging treatment with low molecular weight heparin did not prevent major thromboembolism.

11 Jun, 2021 | 08:19h | UTC

Postoperative low molecular weight heparin bridging treatment for patients at high risk of arterial thromboembolism (PERIOP2): double blind randomised controlled trial – The BMJ

 

Commentary on Twitter

 


M-A: Safety of thoracentesis and tube thoracostomy in patients with uncorrected coagulopathy.

11 Jun, 2021 | 08:15h | UTC

Safety of Thoracentesis and Tube Thoracostomy in Patients With Uncorrected Coagulopathy: A Systematic Review and Meta-analysis – CHEST

Commentary: Is Thoracentesis Safe in Coagulopathic Patients? – JournalFeed

 


Case series: Adjunct immune globulin for vaccine-induced thrombotic thrombocytopenia.

10 Jun, 2021 | 09:46h | UTC

Adjunct Immune Globulin for Vaccine-Induced Thrombotic Thrombocytopenia – New England Journal of Medicine

 


Review: Management of patients with venous thromboembolism after the initial treatment period.

8 Jun, 2021 | 09:13h | UTC

Management of Patients With Venous Thromboembolism After the Initial Treatment Period – The Journal of the American Board of Family Medicine

 


RCT: In patients hospitalized with Covid-19 with elevated D-Dimer, a full-dose anticoagulation strategy based on rivaroxaban (full-dose heparins in unstable patients) + rivaroxaban to day 30 was not better than prophylactic anticoagulation and increased bleeding risk.

7 Jun, 2021 | 00:01h | UTC

Therapeutic versus prophylactic anticoagulation for patients admitted to hospital with COVID-19 and elevated D-dimer concentration (ACTION): an open-label, multicentre, randomised, controlled trial – The Lancet

Related: #ACC21 – [Not published yet] RCT: Among hospitalized patients with Covid-19 and elevated D-Dimer, therapeutic anticoagulation with Rivaroxaban 20 mg was not associated with improved outcomes and resulted in increased major bleeding.

 

Commentary on Twitter

 


Case report: Successful treatment of vaccine-induced prothrombotic immune thrombocytopenia (VIPIT).

6 Jun, 2021 | 23:55h | UTC

Successful treatment of vaccine-induced prothrombotic immune thrombocytopenia (VIPIT) – Journal of Thrombosis and Haemostasis

Commentary: COVID-19 vaccination: Thrombosis can be prevented by prompt treatment, researchers report – Medical University of Vienna

 


Update on the diagnosis and treatment of POEMS (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal Gammopathy, and Skin Changes) Syndrome.

6 Jun, 2021 | 23:37h | UTC

Update on the Diagnosis and Treatment of POEMS (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal Gammopathy, and Skin Changes) Syndrome: A Review – JAMA Oncology (free for a limited period)

 


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