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Radiation Oncology

RCT | Intensity-modulated radiotherapy vs. stereotactic body radiotherapy for prostate cancer.

19 Sep, 2022 | 12:31h | UTC

Intensity-modulated radiotherapy versus stereotactic body radiotherapy for prostate cancer (PACE-B): 2-year toxicity results from an open-label, randomised, phase 3, non-inferiority trial – The Lancet Oncology (link to abstract – $ for full-text)

 

Commentary from the author on Twitter (thread – click for more)

 


RCT | Busulfan plus Cyclophosphamide is noninferior to total body irradiation plus Cyclophosphamide for adults Acute B Lymphoblastic Leukemia.

11 Sep, 2022 | 22:24h | UTC

Busulfan Plus Cyclophosphamide Versus Total Body Irradiation Plus Cyclophosphamide for Adults Acute B Lymphoblastic Leukemia: An Open-Label, Multicenter, Phase III Trial – Journal of Clinical Oncology

 


Guideline | Patient preparation and radiation protection guidance for adult patients undergoing radioiodine treatment for thyroid cancer.

1 Sep, 2022 | 11:53h | UTC

Patient Preparation and Radiation Protection Guidance for Adult Patients Undergoing Radioiodine Treatment for Thyroid Cancer in the UK – Clinical Oncology

 


Cohort Study | 5-year follow-up results suggest it is safe to de-escalate radiotherapy after primary chemotherapy in cT1–2N1 breast cancer.

31 Aug, 2022 | 11:45h | UTC

De-escalation of radiotherapy after primary chemotherapy in cT1–2N1 breast cancer (RAPCHEM; BOOG 2010–03): 5-year follow-up results of a Dutch, prospective, registry study – The Lancet Oncology (link to abstract – $ for full-text)

Commentary: Treatment De-Escalation With Locoregional Radiotherapy Appears Safe in cT1-2N1 Breast Cancer – Cancer Network

 

Commentary on Twitter

 


Systematic Review | Hysterectomy with radiotherapy or chemotherapy or both for women with locally advanced cervical cancer.

26 Aug, 2022 | 13:11h | UTC

Hysterectomy with radiotherapy or chemotherapy or both for women with locally advanced cervical cancer – Cochrane Library

Summary: Hysterectomy with medical management for cervical cancer that has spread to nearby tissues only – Cochrane Library

 


RCT | In patients with low-risk nasopharyngeal carcinoma, radiotherapy alone was noninferior to radiotherapy plus concurrent chemoradiotherapy on survival without disease relapse at 3 years.

25 Aug, 2022 | 12:13h | UTC

Effect of Radiotherapy Alone vs Radiotherapy With Concurrent Chemoradiotherapy on Survival Without Disease Relapse in Patients With Low-risk Nasopharyngeal Carcinoma: A Randomized Clinical Trial – JAMA (free for a limited period)

Video Editor’s Note: Radiotherapy With vs Without Chemoradiotherapy in Low-risk Nasopharyngeal Carcinoma – JAMA

 


The contemporary management of cancers of the sinonasal tract in adults.

16 Aug, 2022 | 13:39h | UTC

The contemporary management of cancers of the sinonasal tract in adults – CA: A Cancer Journal for Clinicians

 


RCT | Radiation doses and fractionation schedules in non-low-risk ductal carcinoma in situ in the breast.

9 Aug, 2022 | 12:46h | UTC

Radiation doses and fractionation schedules in non-low-risk ductal carcinoma in situ in the breast (BIG 3–07/TROG 07.01): a randomised, factorial, multicentre, open-label, phase 3 study – The Lancet (link to abstract – $ for full-text)

 


RCT | Palliative radiation for advanced central lung tumors with intentional avoidance of the esophagus.

9 Aug, 2022 | 12:24h | UTC

Palliative Radiation for Advanced Central Lung Tumors With Intentional Avoidance of the Esophagus (PROACTIVE): A Phase 3 Randomized Clinical Trial – JAMA Oncology

Commentary: Esophagus-Sparing Radiation Fails QOL Test in Lung Cancer— Esophageal-specific quality of life no better, but treatment reduced symptomatic esophagitis – MedPage Today (free registration required)

 

Commentary on Twitter

 


RCT | Partial breast irradiation vs. whole breast irradiation for early breast cancer.

8 Aug, 2022 | 11:36h | UTC

Partial Breast Irradiation Versus Whole Breast Irradiation for Early Breast Cancer Patients in a Randomized Phase III Trial: The Danish Breast Cancer Group Partial Breast Irradiation Trial – Journal of Clinical Oncology (link to abstract – $ for full-text)

 


ASTRO Guideline | Radiation therapy for IDH-mutant grade 2 and grade 3 diffuse glioma.

29 Jul, 2022 | 12:33h | UTC

Radiation Therapy for IDH-Mutant Grade 2 and Grade 3 Diffuse Glioma: An ASTRO Clinical Practice Guideline – Practical Radiation Oncology

 


Cohort Study | Assessment of second primary cancer risk among men receiving primary radiotherapy vs. surgery for the treatment of prostate cancer.

29 Jul, 2022 | 12:23h | UTC

Assessment of Second Primary Cancer Risk Among Men Receiving Primary Radiotherapy vs Surgery for the Treatment of Prostate Cancer – JAMA Network Open

 

Commentary on Twitter

 


Phase 2 RCT | Deintensified chemoradiotherapy for pretreatment Epstein-Barr Virus DNA-selected low-risk locoregionally advanced nasopharyngeal carcinoma.

19 Jul, 2022 | 12:58h | UTC

Deintensified Chemoradiotherapy for Pretreatment Epstein-Barr Virus DNA-Selected Low-Risk Locoregionally Advanced Nasopharyngeal Carcinoma: A Phase II Randomized Noninferiority Trial – Journal of Clinical Oncology (link to abstract – $ for full-text)

Commentaries:

#VisualAbstract: Pretreatment with radiotherapy and two cycles of concurrent cisplatin may reduce toxicity in locally advanced nasopharyngeal carcinoma – Physician’s Weekly

Intensity-Modulated Radiotherapy Plus 2 Cycles of Concurrent Cisplatin Improved Low-Risk LA-NPC Outcomes – Cancer Network

 

Commentary on Twitter

 


Phase 2 RCT | Efficacy of preoperative mFOLFIRINOX vs. mFOLFIRINOX plus hypofractionated radiotherapy for borderline resectable adenocarcinoma of the pancreas.

15 Jul, 2022 | 12:29h | UTC

Efficacy of Preoperative mFOLFIRINOX vs mFOLFIRINOX Plus Hypofractionated Radiotherapy for Borderline Resectable Adenocarcinoma of the PancreasThe A021501 Phase 2 Randomized Clinical Trial – JAMA Oncology (free for a limited period)

Editorial: The Continued Struggle for Defining a Role for Radiotherapy in Pancreas Cancer – JAMA (free for a limited period)

News Release: Preoperative combination chemotherapy improved survival in patients with pancreatic cancer – The University of Texas MD Anderson Cancer Center

 

Commentary on Twitter

 


Female erectile tissues and sexual dysfunction after pelvic radiotherapy: a scoping review.

13 Jul, 2022 | 11:23h | UTC

Female erectile tissues and sexual dysfunction after pelvic radiotherapy: A scoping review – CA: A Cancer Journal for Clinicians

 


Phase II RCT | Proton craniospinal irradiation vs. photon involved-field radiotherapy for patients with solid tumor leptomeningeal metastasis.

13 Jul, 2022 | 11:09h | UTC

Randomized Phase II Trial of Proton Craniospinal Irradiation Versus Photon Involved-Field Radiotherapy for Patients With Solid Tumor Leptomeningeal Metastasis – Journal of Clinical Oncology (link to abstract – $ for full-text)

 


Network M-A | High-dose radiotherapy or androgen deprivation therapy as treatment intensification for localized prostate cancer.

6 Jul, 2022 | 11:09h | UTC

High-dose Radiotherapy or Androgen Deprivation Therapy (HEAT) as Treatment Intensification for Localized Prostate Cancer: An Individual Patient–data Network Meta-analysis from the MARCAP Consortium – European Urology (link to abstract – $ for full-text)

 

Commentary on Twitter

 


Long-term results of RCT: Radiotherapy to the prostate for men with metastatic prostate cancer.

10 Jun, 2022 | 11:10h | UTC

Radiotherapy to the prostate for men with metastatic prostate cancer in the UK and Switzerland: Long-term results from the STAMPEDE randomised controlled trial – PLOS Medicine

 


ESTRO-ACROP guideline on surface guided radiation therapy.

7 Jun, 2022 | 10:53h | UTC

ESTRO-ACROP guideline on surface guided radiation therapy – Radiotherapy & Oncology

 

Commentary on Twitter

 


ESTRO ACROP and SIOPE recommendations for myeloablative total body irradiation in children.

7 Jun, 2022 | 10:52h | UTC

ESTRO ACROP and SIOPE recommendations for myeloablative total body irradiation in children – Radiotherapy & Oncology

 


M-A: Neoadjuvant short-course radiotherapy followed by consolidation chemotherapy before surgery for treating locally advanced rectal cancer.

3 Jun, 2022 | 10:46h | UTC

Neoadjuvant Short-Course Radiotherapy Followed by Consolidation Chemotherapy before Surgery for Treating Locally Advanced Rectal Cancer: A Systematic Review and Meta-Analysis – Current Oncology

 


Phase 2 RCT: Efficacy of epigallocatechin-3-gallate in preventing dermatitis in patients with breast cancer receiving postoperative radiotherapy.

2 Jun, 2022 | 10:34h | UTC

Efficacy of Epigallocatechin-3-Gallate in Preventing Dermatitis in Patients With Breast Cancer Receiving Postoperative Radiotherapy: A Double-Blind, Placebo-Controlled, Phase 2 Randomized Clinical Trial – JAMA Dermatology (free for a limited period)

Visual Abstract: Efficacy of Epigallocatechin-3-Gallate on Dermatitis in Patients With Breast Cancer Receiving Postoperative Radiotherapy

 


M-A: Stereotactic radiosurgery vs. whole brain radiotherapy in patients with intracranial metastatic disease and small-cell lung cancer.

30 May, 2022 | 10:41h | UTC

Stereotactic radiosurgery versus whole brain radiotherapy in patients with intracranial metastatic disease and small-cell lung cancer: a systematic review and meta-analysis – The Lancet Oncology (link to abstract – $ for full-text)

News Release: Meta-Analysis Shows Targeted Radiation Therapy May Be as Effective as Standard Care for Small Cell Lung Cancer Patients with Brain Metastases – St. Michael’s Hospital

 


RCT: Effect of supine vs. prone breast radiotherapy on acute toxic effects of the skin among women with large breast size.

27 May, 2022 | 11:51h | UTC

Effect of Supine vs Prone Breast Radiotherapy on Acute Toxic Effects of the Skin Among Women With Large Breast Size: A Randomized Clinical Trial – JAMA Oncology (free for a limited period)

Editorial: Prone Whole-Breast Radiotherapy—Better Than Supine? (free for a limited period)

 

Commentary on Twitter

 


AUA/ASTRO Guideline: Clinically localized prostate cancer.

13 May, 2022 | 11:10h | UTC

Homepage: Clinically Localized Prostate Cancer: AUA/ASTRO Guideline – American Urological Association

Part I: Introduction, Risk Assessment, Staging and Risk-Based Management

Part II: Principles of Active Surveillance, Principles of Surgery, and Follow-Up

Part III: Principles of Radiation and Future Directions

Related:

Systematic Review of Active Surveillance for Clinically Localised Prostate Cancer to Develop Recommendations Regarding Inclusion of Intermediate-risk Disease, Biopsy Characteristics at Inclusion and Monitoring, and Surveillance Repeat Biopsy Strategy – European Urology

Therapies for Clinically Localized Prostate Cancer: A Comparative Effectiveness Review – The Journal of Urology

High-dose radiotherapy and risk-adapted androgen deprivation in localised prostate cancer (DART 01/05): 10-year results of a phase 3 randomised, controlled trial – The Lancet Oncology

German S3 Evidence-Based Guidelines on Focal Therapy in Localized Prostate Cancer: The First Evidence-Based Guidelines on Focal Therapy – Urologia Internationalis

Therapies for Clinically Localized Prostate Cancer – Agency for Healthcare Research and Quality

Radical prostatectomy versus deferred treatment for localised prostate cancer – Cochrane Library

 


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