Radiation Oncology
[ESMO2020 press release – Not published yet] Randomized trial: No benefit for post-operative radiotherapy in non-small-cell lung cancer
22 Sep, 2020 | 09:23h | UTCCommentary: Phase 3 Trial Results Do Not Support PORT in Resected Stage IIIAN2 NSCLC – Targeted Oncology
[Abstract Only] Randomized trial: Preoperative radiotherapy plus surgery vs. surgery alone for patients with primary retroperitoneal sarcoma
16 Sep, 2020 | 08:46h | UTCPreoperative radiotherapy plus surgery versus surgery alone for patients with primary retroperitoneal sarcoma (EORTC-62092: STRASS): a multicentre, open-label, randomised, phase 3 trial – The Lancet Oncology (link to abstract – $ for full-text)
Randomized trial: Long term survival and local control outcomes from single dose targeted intraoperative radiotherapy during lumpectomy for early breast cancer
21 Aug, 2020 | 02:27h | UTCCommentaries: Targeted intraoperative radiotherapy for early breast cancer—new evidence challenges traditional treatment – The BMJ Opinion AND Long-term TARGIT-A data support single-dose intraoperative breast cancer radiotherapy – medwire News
[Abstract Only] Randomized trial: Hypofractionated vs. conventional fractionated radiotherapy after breast-conserving surgery
18 Aug, 2020 | 07:15h | UTC
Active monitoring, radical prostatectomy and radical radiotherapy in PSA-detected clinically localised prostate cancer: the ProtecT three-arm RCT
13 Aug, 2020 | 00:02h | UTC
ASTRO Guideline: Radiation Therapy for Cervical Cancer
11 Jun, 2020 | 09:20h | UTCCommentary: ASTRO’s new guideline provides recommendations for radiation therapy to treat cervical cancer – News Medical
Randomized Trial: Hypofractionated Breast Radiotherapy for 1 Week Noninferior to 3 weeks
30 Apr, 2020 | 04:02h | UTCCommentaries: 1-week hypofractionated adjuvant whole-breast radiotherapy: towards a new standard? – The Lancet AND One-week course of radiotherapy could benefit women with early stage breast cancer, study finds – Institute of Cancer Research
[Abstract Only] Randomized Trial: Hippocampal Avoidance During Whole-Brain Radiotherapy for Patients with Brain Metastases
10 Mar, 2020 | 10:17h | UTCHippocampal Avoidance During Whole-Brain Radiotherapy Plus Memantine for Patients With Brain Metastases: Phase III Trial NRG Oncology CC001 – Journal of Clinical Oncology (link to abstract – $ for full-text)
Commentaries: Hippocampal avoidance during WBRT reduces risks on NRG Oncology trial – NRG Oncology (free) AND ‘Practice-Changing’ Study on WBRT for Patients With Brain Mets – Medscape (free registration required)
ASTRO Guideline: Definitive and Postoperative Radiation Therapy for Basal and Squamous Cell Cancers of the Skin
21 Jan, 2020 | 01:35h | UTCCommentary: ASTRO Issues Clinical Guideline on Radiation Therapy for Basal Cell and Cutaneous Squamous Cell Carcinomas – The ASCO Post (free)
Observational Study: Patient-Reported Outcomes Through 5 Years for Active Surveillance, Surgery, Brachytherapy, or External Beam Radiation for Localized Prostate Cancer
16 Jan, 2020 | 08:53h | UTCPatient-Reported Outcomes Through 5 Years for Active Surveillance, Surgery, Brachytherapy, or External Beam Radiation With or Without Androgen Deprivation Therapy for Localized Prostate Cancer – JAMA (free for a limited period)
Related Study: Ten-year Outcomes in Men with Localized Prostate Cancer from the ProtecT Randomized Controlled Trial According to Treatment Received (free)
Commentaries: Prostatectomy-associated urinary incontinence disparities persist at 5 years – MedwireNews (free) AND Prostate Cancer Treatment Side Effects Worse With Prostatectomy – Renals & Urology News (free)
[Abstract Only] Randomized Trial: External Beam Accelerated Partial Breast Irradiation vs. Whole Breast Irradiation after Breast Conserving Surgery in Women with Ductal Carcinoma in Situ and Node-negative Breast Cancer
5 Jan, 2020 | 13:08h | UTCExternal beam accelerated partial breast irradiation versus whole breast irradiation after breast conserving surgery in women with ductal carcinoma in situ and node-negative breast cancer (RAPID): a randomised controlled trial – The Lancet (link to abstract – $ for full-text)
Commentary: Results mixed for twice-daily APBI in early breast cancer – MedicalXpress (free)
Related Commentary on Twitter
NEW: External beam accelerated partial breast irradiation was non-inferior to whole breast irradiation in preventing ipsilateral breast tumour recurrence: finding from the RAPID randomised controlled trial https://t.co/4aexxXC8Vg pic.twitter.com/JMa0jUWY1X
— The Lancet (@TheLancet) December 6, 2019
[Abstract Only] Randomized Trial: Accelerated Partial Breast Irradiation vs. Whole-breast Irradiation After Breast-conserving Surgery for Early-stage Breast Cancer
5 Jan, 2020 | 13:05h | UTCLong-term primary results of accelerated partial breast irradiation after breast-conserving surgery for early-stage breast cancer: a randomised, phase 3, equivalence trial – The Lancet (link to abstract – $ for full-text)
Related Commentary on Twitter
PRESS RELEASE: Accelerated Partial Breast Irradiation Although Close was Not Equivalent to Whole-breast Irradiation to Control Ipsilateral Breast Tumor Recurrence https://t.co/mCvuC5aeag #breastcancer pic.twitter.com/KRXAAtAjbj
— NRG Oncology (@NRGonc) December 6, 2019
Randomized Trial: Single-Fraction vs. Multifraction Radiotherapy for Spinal Canal Compression from Metastatic Cancer
4 Dec, 2019 | 08:18h | UTCEffect of Single-Fraction vs Multifraction Radiotherapy on Ambulatory Status Among Patients With Spinal Canal Compression From Metastatic Cancer: The SCORAD Randomized Clinical Trial – JAMA (free for a limited period)
Commentary: One dose of radiotherapy as effective as five doses for cancer in the spine – University College London (free)
Randomized Trial: Synchronous vs. Sequential Chemo-radiotherapy in Patients with Early Stage Breast Cancer
4 Dec, 2019 | 08:17h | UTC
Ten-year Outcomes in Men with Localized Prostate Cancer from the ProtecT Randomized Controlled Trial According to Treatment Received
29 Nov, 2019 | 08:24h | UTCOriginal Study: 10-Year Outcomes after Monitoring, Surgery, or Radiotherapy for Localized Prostate Cancer – New England Journal of Medicine (free)
Related Commentary on Twitter
Ten-year Mortality, Disease Progression, and Treatment-related Side Effects in Men with Localised Prostate Cancer from the ProtecT Randomised Controlled Trial According to Treatment Received@Freddie_Hamdy @JimCatto https://t.co/sNfevwU3R4 pic.twitter.com/uqnoZUgSRm
— European Urology (@EUplatinum) November 25, 2019
Meta-Analysis: Early vs. Delayed Surgery After Short-course Radiotherapy for Rectal Cancer
24 Nov, 2019 | 20:41h | UTC
Deep Learning: A Review for the Radiation Oncologist
29 Oct, 2019 | 02:16h | UTCDeep Learning: A Review for the Radiation Oncologist – Frontiers in Oncology (free)
Perspective: Alternative Payment for Radiation Oncology
10 Oct, 2019 | 09:15h | UTCAlternative Payment for Radiation Oncology – JAMA (free for a limited period)
#ESMO19 – [Not Published Yet] Randomized Trial: Many Men with Prostate Cancer May Avoid Postoperative Radiotherapy, Study Suggests
30 Sep, 2019 | 00:39h | UTCMen with Prostate Cancer can be Spared Radiotherapy after Surgery [ESMO 2019 Press Release] (free)
See also: ESMO 2019: Men With Prostate Cancer May Avoid Postoperative Radiotherapy, Study Finds – The ASCO Post (free) AND Skipping Radiotherapy After Surgery for Prostate Cancer – Medscape (free registration required)
#ESMO19 – Just presented at the European Society of Medical Oncology Congress 2019 in Barcelona
ASTRO Guideline: Radiation Therapy for Pancreatic Cancer
12 Sep, 2019 | 08:01h | UTCCommentaries: ASTRO Guideline on Use of Radiation Therapy for Patients With Pancreatic Cancer – The ASCO Post (free) AND New guideline clarifies role of radiation therapy in pancreatic cancer treatment – American Society for Radiation Oncology (free)
[Abstract Only] Randomized Trial: Adjuvant Radiotherapy Following Radical Prostatectomy vs. Radical Prostatectomy Alone in Prostate Cancer Patients with Positive Margins or Extracapsular Extension
10 Sep, 2019 | 00:56h | UTCRandomised Trial of Adjuvant Radiotherapy Following Radical Prostatectomy Versus Radical Prostatectomy Alone in Prostate Cancer Patients with Positive Margins or Extracapsular Extension – European Urology (link to abstract – $ for full-text)
Commentaries: Adjuvant Radiotherapy After Radical Prostatectomy vs Radical Prostatectomy Alone in Patients With Positive Margins or Extracapsular Extension – The ASCO Post (free) AND Adjuvant radiotherapy may be beneficial in treating locally advanced prostate cancer – University of Helsinki (free)
Source: EvidenceAlerts
Systematic Review: Hypofractionation (Fewer, Larger Doses of Daily Radiation) for Clinically Localized Prostate Cancer Results in Similar Oncologic Outcomes
8 Sep, 2019 | 23:00h | UTCHypofractionation for clinically localized prostate cancer – Cochrane Library (free)
Randomized Trial: Neoadjuvant Radiotherapy for Resectable Hepatocellular Carcinoma With Portal Vein Tumor Thrombus
27 Aug, 2019 | 00:09h | UTCCommentary: Neoadjuvant Radiotherapy vs Surgery Alone for Resectable Hepatocellular Carcinoma With Tumor Thrombus – The ASCO Post (free)
Source: EvidenceAlerts
Brachytherapy: An Overview for Clinicians
25 Aug, 2019 | 21:09h | UTCBrachytherapy: An overview for clinicians – CA: A Cancer Journal for Clinicians (free)
Study: Association of Radioactive Iodine Treatment With Cancer Mortality in Patients With Hyperthyroidism
2 Jul, 2019 | 06:20h | UTCCommentaries: NIH study finds long-term increased risk of cancer death following common treatment for hyperthyroidism – NIH News Releases (free) AND Treatment for overactive thyroid linked to increased risk of dying from cancer – CNN (free) AND Expert reaction to study looking at radioactive iodine treatment for overactive thyroid and risk of cancer – Science Media Centre (free)