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Geriatrics

M-A | Community-based interventions using holistic assessment and care planning improve independent living in older adults

9 Aug, 2023 | 15:13h | UTC

Complex interventions for improving independent living and quality of life amongst community-dwelling older adults: a systematic review and meta-analysis – Age and Ageing

 


M-A | Nearly 37% of elderly outpatients are at risk due to potentially inappropriate medication use

8 Aug, 2023 | 13:37h | UTC

Prevalence of Use of Potentially Inappropriate Medications Among Older Adults Worldwide: A Systematic Review and Meta-Analysis – JAMA Network Open

 


M-A | Approximately 25 min/day of walking can boost function and cut adverse events in acutely hospitalized elders

8 Aug, 2023 | 13:35h | UTC

Optimal dose and type of physical activity to improve functional capacity and minimise adverse events in acutely hospitalised older adults: a systematic review with dose-response network meta-analysis of randomised controlled trials – British Journal of Sports Medicine (free for a limited period)

 


Perspective | Will unpredictable side effects dim the promise of new Alzheimer’s drugs?

8 Aug, 2023 | 13:30h | UTC

Will unpredictable side effects dim the promise of new Alzheimer’s drugs? – Science (a few articles per month are free)

Related:

RCT | Donanemab slows early symptomatic Alzheimer’s progression, but raises serious safety concerns

RCT | Lecanemab slows cognitive decline in early Alzheimer’s disease but raises safety concerns

 


Perspective | The paradoxical decline of geriatric medicine as a profession

7 Aug, 2023 | 14:57h | UTC

The Paradoxical Decline of Geriatric Medicine as a Profession – JAMA (free for a limited period)

 

Commentary on Twitter

 


Expert Panel | Assessment and management of older adults undergoing percutaneous coronary intervention

7 Aug, 2023 | 14:55h | UTC

Assessment and Management of Older Adults Undergoing PCI, Part 1: A JACC: Advances Expert Panel – Journal of the American College of Cardiology

A Geriatric Approach to Percutaneous Coronary Interventions in Older Adults, Part II: A JACC: Advances Expert Panel – Journal of the American College of Cardiology

 


ESPEN guideline on nutritional support for polymorbid medical inpatients

7 Aug, 2023 | 14:52h | UTC

ESPEN guideline on nutritional support for polymorbid medical inpatients – Clinical Nutrition

 


KDIGO Conference | Managing the symptom burden associated with maintenance dialysis

4 Aug, 2023 | 12:02h | UTC

Managing the symptom burden associated with maintenance dialysis: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference – Kidney International

News Release: KDIGO Announces Publication of “Managing the Symptom Burden Associated with Maintenance Dialysis”

 

Commentary on Twitter

 


Cohort Study | Depression at any life stage linked to increased dementia incidence

2 Aug, 2023 | 13:49h | UTC

Association of Early-, Middle-, and Late-Life Depression With Incident Dementia in a Danish Cohort – JAMA Neurology (link to abstract – $ for full-text)

Commentary: Depression Over Adulthood May Increase Risk of Dementia – Psychiatric News Alert

 


RCT | Combined endovenous ablation and compression speeds up venous leg ulcers healing

31 Jul, 2023 | 13:49h | UTC

Endovenous ablation for venous leg ulcers – Cochrane Library

Summary: What are the benefits and risks of endovenous ablation (using heat or medication to permanently close veins) for treating venous leg ulcers – Cochrane Library

 


Position Paper | Prioritizing deprescribing in fall prevention strategies

28 Jul, 2023 | 14:12h | UTC

European position paper on polypharmacy and fall-risk-increasing drugs recommendations in the World Guidelines for Falls Prevention and Management: implications and implementation – European Geriatric Medicine

Original Guideline: World guidelines for falls prevention and management for older adults: a global initiative – Age and Ageing

 


Perspective | Reconsidering the language of serious illness

26 Jul, 2023 | 13:29h | UTC

Reconsidering the Language of Serious Illness – JAMA (free for a limited period)

 

Commentary on Twitter

 


Mitigating neurological, cognitive, and psychiatric sequelae of COVID-19-related critical illness

26 Jul, 2023 | 13:28h | UTC

Mitigating neurological, cognitive, and psychiatric sequelae of COVID-19-related critical illness – The Lancet Respiratory Medicine

 


Giving a voice to patients at high risk of dying in the intensive care unit: a multiple source approach

26 Jul, 2023 | 13:20h | UTC

Giving a voice to patients at high risk of dying in the intensive care unit: a multiple source approach – Intensive Care Medicine (free for a limited period)

 

Commentary on Twitter

 


Perspective | Digital health for aging populations

24 Jul, 2023 | 13:13h | UTC

Digital health for aging populations – Nature Medicine (if the link is paywalled, try this one)

 


RCT | MIND diet, a hybrid of Mediterranean and DASH, shows no superiority in preventing cognitive decline

21 Jul, 2023 | 13:38h | UTC

Trial of the MIND Diet for Prevention of Cognitive Decline in Older Persons – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries:

‘MIND diet,’ intended to prevent dementia, doesn’t offer significant brain benefit, trial suggests – Live Science

Revised Mediterranean Diet Shows No Significant Impact on Cognition, MRI Outcomes in Older Persons – Neurology Live

 

Commentary on Twitter

 


RCT | Half-dose Tenecteplase + later PCI if indicated seems to be viable option in older individuals when timely PCI is unavailable

21 Jul, 2023 | 13:36h | UTC

Half-Dose Tenecteplase or Primary Percutaneous Coronary Intervention in Older Patients With ST-Segment–Elevation Myocardial Infarction in STREAM-2: A Randomized, Open-Label Trial – Circulation (link to abstract – $ for full-text)

 

Commentary on Twitter

 


RCT | Hearing intervention fails to impact 3-year cognitive decline in older adults

20 Jul, 2023 | 11:09h | UTC

Hearing intervention versus health education control to reduce cognitive decline in older adults with hearing loss in the USA (ACHIEVE): a multicentre, randomised controlled trial – The Lancet (link to abstract – $ for full-text)

 

Commentary on Twitter

 


Systematic Review | Outcomes in deprescribing implementation trials and compliance with expert recommendations

20 Jul, 2023 | 10:55h | UTC

Outcomes in deprescribing implementation trials and compliance with expert recommendations: a systematic review – BMC Geriatrics

Related:

Clinical practice guideline for deprescribing opioid analgesics: summary of recommendations – Medical Journal of Australia

RCT | Opioids not more effective than placebo for acute low back and neck pain

Deprescribing considerations for older people in general practice – Australian Journal of General Practice

Deprescribing Strategies for Opioids and Benzodiazepines with Emphasis on Concurrent Use: A Scoping Review – Journal of Clinical Medicine

An Overview of Systematic Reviews and Meta-Analyses on the Effect of Medication Interventions Targeting Polypharmacy for Frail Older Adults – Journal of Clinical Medicine

Physician-led medication reviews in polypharmacy patients treated with at least 12 medications in a type 2 diabetes outpatient clinic: a randomised trial – Diabetic Medicine

RCT | A deprescribing intervention reduced medication burden among older adults in post-acute care

Achieving sustainable healthcare through deprescribing of unnecessary medications: making sense of the evidence – Cochrane Library

Deprescribing medicines in older people living with multimorbidity and polypharmacy: the TAILOR evidence synthesis – Health Technology Assessment

Barriers and facilitators to deprescribing of cardiovascular medications: a systematic review – BMJ Open

A National Modified Delphi Consensus Process to Prioritize Experiences and Interventions for Antipsychotic Medication Deprescribing Among Adult Patients With Critical Illness – Critical Care Explorations

Deprescribing proton pump inhibitors – Australian Journal of General Practice

Medication reviews and deprescribing as a single intervention in falls prevention: a systematic review and meta-analysis – Age and Ageing

Optimizing Medication Use in Older Adults With Rheumatic Musculoskeletal Diseases: Deprescribing as an Approach When Less May Be More – ACP Open Rheumatology

Facing the challenge of polypharmacy when prescribing for older people with cardiovascular disease. A review by the European Society of Cardiology Working Group on Cardiovascular Pharmacotherapy – European Heart Journal – Cardiovascular Pharmacotherapy

Deprescribing in Older Adults with Cardiovascular Disease – Journal of the American College of Cardiology

Multimorbidity in Older Adults with Cardiovascular Disease – American College of Cardiology, Latest in Cardiology

Antihypertensive Deprescribing in Older Adults: a Practical Guide – Current Hypertension Reports

How-to guide for medication reviews in older adults with cancer: A Young International Society of Geriatric Oncology and Nursing & Allied Health Interest Group initiative – Journal of Geriatric Oncology

Deprescribing in Palliative Cancer Care – Life

Less is More: Deprescribing Medications in Older Adults with Kidney Disease: A Review – Kidney360

Process evaluation of implementation strategies to reduce potentially inappropriate medication prescribing in older population: A scoping review – Research in Social and Administrative Pharmacy

AGA Clinical Practice Update on De-Prescribing of Proton Pump Inhibitors: Expert Review – Gastroenterology

Development of a Metric to Detect and Decrease Low-Value Prescribing in Older Adults – JAMA Network Open

The MedSafer Study—Electronic Decision Support for Deprescribing in Hospitalized Older Adults: A Cluster Randomized Clinical Trial – JAMA Internal Medicine

Quantifying Anticholinergic Burden and Sedative Load in Older Adults with Polypharmacy: A Systematic Review of Risk Scales and Models – Drugs & Aging

Deprescribing in palliative patients with cancer: a concise review of tools and guidelines – Supportive Care in Cancer

Prescribing practices, patterns, and potential harms in patients receiving palliative care: A systematic scoping review – Exploratory Research in Clinical and Social Pharmacy

A narrative review of evidence to guide deprescribing among older adults – Journal of General and Family Medicine

Polypharmacy, inappropriate prescribing, and deprescribing in older people: through a sex and gender lens – The Lancet Health Longevity

Polypharmacy Management in Older Patients – Mayo Clinic Proceedings

Psychopharmacological Treatment in Older People: Avoiding Drug Interactions and Polypharmacy – Deutsches Ärzteblatt international

Eliminating Medication Overload: A National Action Plan – Lown Institute

International Group for Reducing Inappropriate Medication Use & Polypharmacy (IGRIMUP): Position Statement and 10 Recommendations for Action – Drugs & Aging

Common ED Medication Errors: Polypharmacy – emDocs

Current and future perspectives on the management of polypharmacy – BMC Family Practice

Routine deprescribing of chronic medications to combat polypharmacy – Therapeutic Advances in Drug Safety

Polypharmacy—an Upward Trend with Unpredictable Effects – Deutsches Ärzteblatt international

Clinical Consequences of Polypharmacy in Elderly – Expert Opinion on Drug Safety

 


ASCO Guideline | Practical assessment and management of vulnerabilities in older patients receiving systemic cancer therapy

19 Jul, 2023 | 14:31h | UTC

Practical Assessment and Management of Vulnerabilities in Older Patients Receiving Systemic Cancer Therapy: ASCO Guideline Update – Journal of Clinical Oncology

 


RCT | Donanemab slows early symptomatic Alzheimer’s progression, but raises serious safety concerns

18 Jul, 2023 | 13:51h | UTC

Donanemab in Early Symptomatic Alzheimer Disease: The TRAILBLAZER-ALZ 2 Randomized Clinical Trial – JAMA (free for a limited period)

Editorials:

Donanemab for Alzheimer Disease—Who Benefits and Who Is Harmed? – JAMA (free for a limited period)

Amyloid-Targeting Monoclonal Antibodies for Alzheimer Disease – JAMA (free for a limited period)

Ushering in a New Era of Alzheimer Disease Therapy – JAMA (free for a limited period)

See also: Visual Abstract

Commentary: Expert reaction to results from Eli Lilly on its anti-amyloid drug donanemab – Science Media Centre

Related: RCT | Lecanemab slows cognitive decline in early Alzheimer’s disease but raises safety concerns.

 


RCT | Prostatic artery embolization improves symptoms more than combined medical therapy in BPH patients

18 Jul, 2023 | 13:34h | UTC

Prostatic artery embolisation versus medical treatment in patients with benign prostatic hyperplasia (PARTEM): a randomised, multicentre, open-label, phase 3, superiority trial – The Lancet Regional Health – Europe

 


Guideline | Diagnosis and treatment of fragility fractures of the pelvis

14 Jul, 2023 | 12:39h | UTC

Clinical Guidelines for the Diagnosis and Treatment of Fragility Fractures of the Pelvis – Orthopaedic Surgery

 


Practice Guidance | Six steps to better care for older people in acute hospitals

12 Jul, 2023 | 14:00h | UTC

Six steps to better care for older people in acute hospitals – British Geriatrics Society

News Release: New guidance outlines ‘Six steps to better care for older people in hospital’ – British Geriatrics Society

 


Cohort Study | Long-term use of menopausal hormone therapy linked to heightened dementia risk

11 Jul, 2023 | 14:04h | UTC

Menopausal hormone therapy and dementia: nationwide, nested case-control study – The BMJ

Editorial: Menopausal hormone therapy and dementia – The BMJ

News Release: Menopausal hormone therapy linked to increased rate of dementia – BMJ Newsroom

Commentaries: Expert reaction to observational study on HRT and dementia – Science Media Centre

 


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