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Systematic Reviews

Systematic review: Peripheral nerve blocks for hip fractures reduce pain on movement, risk of acute confusional state, risk of chest infection, and time to first mobilization

27 Nov, 2020 | 08:37h | UTC

Peripheral nerve blocks for hip fractures in adults – Cochrane Library

Summary: Do local anaesthetic nerve blocks provide effective pain relief for adults with a hip fracture? – Cochrane Library

 


Meta-analysis: Among the treatment interventions to maintain abstinence from alcohol in primary care, acamprosate was the only intervention with enough evidence of benefit

26 Nov, 2020 | 08:55h | UTC

Treatment interventions to maintain abstinence from alcohol in primary care: systematic review and network meta-analysis – The BMJ

 

Commentary on Twitter

 


Cochrane review finds we are still uncertain about the effects of face masks to reduce the spread of respiratory viruses. Editorial: “Policy makers must act on incomplete evidence in responding to COVID‐19”

23 Nov, 2020 | 09:51h | UTC

Physical interventions to interrupt or reduce the spread of respiratory viruses – Cochrane Library

Editorial: Policy makers must act on incomplete evidence in responding to COVID‐19

Commentary: Face masks cut disease spread in the lab, but have less impact in the community. We need to know why – The Conversation

 


Systematic review: Ultra-long‐acting insulins provide modest benefit compared to NPH insulin for Type 2 DM, resulting in reduced risk of hypoglycemia but no difference in HbA1c

23 Nov, 2020 | 09:45h | UTC

(Ultra‐)long‐acting insulin analogues versus NPH insulin (human isophane insulin) for adults with type 2 diabetes mellitus – Cochrane Library

Summary: (Ultra-)long-acting insulin analogues compared with NPH insulin (human isophane insulin) for adults with type 2 diabetes mellitus

 


Systematic review: Interventions for breathlessness in patients with advanced cancer

23 Nov, 2020 | 09:43h | UTC

Interventions for Breathlessness in Patients With Advanced Cancer – Agency for Healthcare Research and Quality

Full report: Interventions for breathlessness in patients with advanced cancer

Evidence Summary: Interventions for breathlessness in patients with advanced cancer

 


Systematic review: Management of primary headaches in pregnancy

18 Nov, 2020 | 09:00h | UTC

Management of Primary Headaches in Pregnancy – Agency for Healthcare Research and Quality

Full report: Management of Primary Headaches in Pregnancy

Evidence Summary: Management of Primary Headaches in Pregnancy

 


Systematic review: Evidence-based practices for acute respiratory failure and Acute Respiratory Distress Syndrome

17 Nov, 2020 | 09:37h | UTC

Evidence-Based Practices for Acute Respiratory Failure and Acute Respiratory Distress Syndrome – CHEST

Commentary: Best practices for mechanical ventilation in patients with ARDS, COVID-19 – University of Michigan

 


Sleep problems in dementia: Despite many drugs being widely prescribed, systematic review finds lack of evidence and no randomized controlled trials to guide decisions about drug treatment

17 Nov, 2020 | 09:29h | UTC

Pharmacotherapies for sleep disturbances in dementia – Cochrane Library

 


Systematic review: Inotropic agents and vasodilator strategies for the treatment of cardiogenic shock or low cardiac output syndrome. “At present, there are no convincing data supporting any specific inotropic or vasodilating therapy to reduce mortality in hemodynamically unstable patients with CS or LCOS.”

10 Nov, 2020 | 09:30h | UTC

Inotropic agents and vasodilator strategies for the treatment of cardiogenic shock or low cardiac output syndrome – Cochrane Library

 


Systematic Review: Little benefit from phlebotonics in patients with venous insufficiency

5 Nov, 2020 | 08:54h | UTC

Phlebotonics for venous insufficiency – Cochrane Library

 


A systematic review of rehabilitation and exercise recommendations in oncology guidelines

29 Oct, 2020 | 09:02h | UTC

A systematic review of rehabilitation and exercise recommendations in oncology guidelines – CA: A Cancer Journal for Clinicians

 

Commentary on Twitter

 


Systematic review: PCSK9 monoclonal antibodies for the primary and secondary prevention of cardiovascular disease

29 Oct, 2020 | 08:57h | UTC

PCSK9 monoclonal antibodies for the primary and secondary prevention of cardiovascular disease – Cochrane Library

Summary: PCSK9 inhibitors for prevention of cardiovascular disease – Cochrane Library

 


Meta-analysis: Most therapies for fibromyalgia are not supported by high-quality evidence

28 Oct, 2020 | 08:52h | UTC

Association of Therapies With Reduced Pain and Improved Quality of Life in Patients With Fibromyalgia: A Systematic Review and Meta-analysis – JAMA Internal Medicine (free for a limited period)

Commentary: Evidence Lacking for Most Fibromyalgia Treatments, Meta-Analysis Finds – NEJM Journal Watch

 


Systematic review: Antithrombotic drugs for people with antiphospholipid syndrome

28 Oct, 2020 | 08:50h | UTC

Antiplatelet and anticoagulant agents for secondary prevention of stroke and other thromboembolic events in people with antiphospholipid syndrome – Cochrane Library

Summary: Anticoagulant drugs or antiplatelet drugs, or both, for reducing the risk of blood clots and stroke in people with antiphospholipid syndrome – Cochrane Library

 


Narrative systematic review: Benefits of medication charts provided at transitions of care

25 Oct, 2020 | 23:29h | UTC

Benefits of medication charts provided at transitions of care: a narrative systematic review – BMJ Open

 


Systematic review: Laparoscopic surgery for pain and infertility associated with endometriosis

25 Oct, 2020 | 23:23h | UTC

Laparoscopic surgery for pain and infertility associated with endometriosis – Cochrane Library

Original study: Laparoscopic surgery for endometriosis – Cochrane Library

 

Commentary on Twitter

 


Meta-analysis: Preventive malaria treatment among school-aged children in sub-Saharan Africa

25 Oct, 2020 | 23:22h | UTC

Preventive malaria treatment among school-aged children in sub-Saharan Africa: a systematic review and meta-analyses – The Lancet Global Health

Commentaries: Landmark Study Suggests Malaria-Preventive Drugs Dramatically Reduce Infections and Improve Health of School Children – University of Maryland AND Back to school for malaria prevention: a new tool in the era of malaria elimination? – The Lancet Global Health

 

Commentary on Twitter

 


Meta-analysis: Dual antiplatelet therapy after percutaneous coronary intervention and drug-eluting stents

22 Oct, 2020 | 09:29h | UTC

Dual Antiplatelet Therapy After Percutaneous Coronary Intervention and Drug-Eluting Stents: A Systematic Review and Network Meta-Analysis – Circulation

 


Meta-analysis: Evaluating prophylactic heparin in ambulatory patients with solid tumors

22 Oct, 2020 | 09:23h | UTC

Evaluating prophylactic heparin in ambulatory patients with solid tumours: a systematic review and individual participant data meta-analysis – The Lancet Haematology (free registration required)

 


Meta-analysis: Drugs for preventing postoperative nausea and vomiting in adults after general anesthesia

21 Oct, 2020 | 09:13h | UTC

Drugs for preventing postoperative nausea and vomiting in adults after general anaesthesia: a network meta‐analysis – Cochrane Library

Summary: Which medicines work best to prevent people from being sick (vomiting) after an operation? – Cochrane Library

 

Commentary on Twitter

 


Vertical transmission of Zika virus and its outcomes: a Bayesian synthesis of prospective studies

20 Oct, 2020 | 01:30h | UTC

Vertical transmission of Zika virus and its outcomes: a Bayesian synthesis of prospective studies – The Lancet Infectious Diseases

Commentary: Desideratum: a developmentalist view of Zika virus infection – The Lancet Infectious Diseases

 


[Abstract Only] Systematic review and meta-analysis of native kidney biopsy complications

20 Oct, 2020 | 01:26h | UTC

Systematic Review and Meta-Analysis of Native Kidney Biopsy Complications – Clinical Journal of the American Society of Nephrology (link to abstract – $ for full-text)

 

Commentary on Twitter

 


Meta-analysis: Evidence-based prevention of Alzheimer’s disease

20 Oct, 2020 | 01:21h | UTC

Evidence-based prevention of Alzheimer’s disease: systematic review and meta-analysis of 243 observational prospective studies and 153 randomised controlled trials – Journal of Neurology, Neurosurgery & Psychiatry

Commentaries: Biggest risk factors identified to try and prevent Alzheimer’s disease – BMJ AND Systematic review finds ten lifestyle factors that clearly impact the probability of developing Alzheimer’s disease (AD) – Sharp Brains

 

Commentary on Twitter

 


[Abstract Only] Meta-analysis: Effect of urate-lowering therapy on cardiovascular and kidney outcomes

20 Oct, 2020 | 01:22h | UTC

Effect of Urate-Lowering Therapy on Cardiovascular and Kidney Outcomes: A Systematic Review and Meta-Analysis – Clinical Journal of the American Society of Nephrology (link to abstract – $ for full-text)

 

Commentary on Twitter

 


Systematic review: Management of colonic diverticulitis

16 Oct, 2020 | 09:25h | UTC

Management of Colonic Diverticulitis – Agency for Healthcare Research and Quality

Full report: Management of Colonic Diverticulitis

Evidence summary: Management of Colonic Diverticulitis

 


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