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Systematic Reviews & Meta-Analysis

M-A: Non-steroidal anti-inflammatory drugs, intravenous fluids, pancreatic stents, or their combinations for the prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis.

16 Jul, 2021 | 10:28h | UTC

Non-steroidal anti-inflammatory drugs, intravenous fluids, pancreatic stents, or their combinations for the prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis: a systematic review and network meta-analysis – The Lancet Gastroenterology & Hepatology (link to abstract – $ for full-text)

 

Commentary on Twitter

 


Severe hearing loss in adults: finding out whether cochlear implants or hearing aids are better.

16 Jul, 2021 | 10:27h | UTC

Severe hearing loss in adults: finding out whether cochlear implants or hearing aids are better – Evidently Cochrane Blog

 

Commentary on Twitter

 


M-A: Little benefit from muscle relaxants for adults with non-specific low back pain.

9 Jul, 2021 | 10:02h | UTC

Efficacy, acceptability, and safety of muscle relaxants for adults with non-specific low back pain: systematic review and meta-analysis – The BMJ

Commentary: New analysis finds muscle relaxant drugs to be largely ineffective for low back pain – News Medical

Related studies: M-A: Effectiveness of treatments for acute and subacute mechanical non-specific low back pain AND RCT: Little benefit from osteopathic manipulative treatment on activity limitations in patients with nonspecific subacute and chronic low back pain AND M-A: Little benefit from antidepressants for low back pain AND Meta-analysis: Little benefit from antidepressants for the treatment of back pain and osteoarthritis AND ACP/AAFP Guideline: Nonpharmacologic and pharmacologic management of acute pain from non–low back, musculoskeletal injuries in adults

 

Commentaries on Twitter

 


Systematic Review: Altered dietary salt intake for people with chronic kidney disease.

9 Jul, 2021 | 09:52h | UTC

Altered dietary salt intake for people with chronic kidney disease – Cochrane Library

Summary: Altered dietary salt intake for adults with chronic kidney disease – Cochrane Library

 

Commentary on Twitter

 


Systematic review: Prophylactic drug management for febrile seizures in children.

9 Jul, 2021 | 09:51h | UTC

Prophylactic drug management for febrile seizures in children – Cochrane Library

Summary: Prophylactic drug management for febrile seizures in children

 


Systematic Review: Pre‐emptive and preventive NSAIDs for postoperative pain in adults undergoing all types of surgery.

9 Jul, 2021 | 09:50h | UTC

Pre‐emptive and preventive NSAIDs for postoperative pain in adults undergoing all types of surgery – Cochrane Library

Summary: Ibuprofen-like painkillers given before cutting the skin in surgery compared with given after cutting the skin in adults undergoing all types of surgery – Cochrane Library

 


M-A: Are antimicrobial stewardship interventions effective and safe in long-term care facilities?

8 Jul, 2021 | 08:52h | UTC

Are antimicrobial stewardship interventions effective and safe in long-term care facilities? A systematic review and meta-analysis – Clinical Microbiology and Infection

 


M-A: Continuation of antidepressants vs. sequential psychological interventions to prevent relapse in depression.

8 Jul, 2021 | 08:50h | UTC

Continuation of Antidepressants vs Sequential Psychological Interventions to Prevent Relapse in Depression: An Individual Participant Data Meta-analysis – JAMA Psychiatry (link to abstract – $ for full-text)

Commentaries: Cognitive Therapy While Tapering Antidepressants May Be Alternative to Maintenance Medication – Psychiatric News Alert AND Psychotherapy Can Prevent Relapse When Discontinuing Antidepressants – Mad in America

 

Commentary on Twitter

 


Systematic review: Immediate antiepileptic drug treatment, versus placebo, deferred, or no treatment for first unprovoked seizure.

8 Jul, 2021 | 08:48h | UTC

Immediate antiepileptic drug treatment, versus placebo, deferred, or no treatment for first unprovoked seizure – Cochrane Library

Summary: Immediate antiepileptic drug treatment, versus placebo, deferred, or no treatment for first unprovoked seizure – Cochrane Library

 


M-A: Convalescent plasma is safe but does not improve outcomes in the treatment of COVID-19.

7 Jul, 2021 | 08:52h | UTC

Systematic review and meta-analysis of randomised controlled trials testing the safety and efficacy of convalescent plasma in the treatment of coronavirus disease 2019 (COVID-19): Evidence-base for practise and implications for research – Transfusion Medicine

 


M-A: Pregnancy After Breast Cancer – “These results provide reassuring evidence on the safety of conceiving in BC survivors”.

6 Jul, 2021 | 09:55h | UTC

Pregnancy After Breast Cancer: A Systematic Review and Meta-Analysis – Journal of Clinical Oncology (link to abstract – $ for full-text)

 

Commentary on Twitter

 


M-A: The efficacy of systemic glucocorticosteroids for pain in rheumatoid arthritis.

6 Jul, 2021 | 09:54h | UTC

The efficacy of systemic glucocorticosteroids for pain in rheumatoid arthritis: a systematic literature review and meta-analysis – Rheumatology

 


Antipsychotic Polypharmacy for the Management of Schizophrenia: Evidence and Recommendations.

5 Jul, 2021 | 01:30h | UTC

Antipsychotic Polypharmacy for the Management of Schizophrenia: Evidence and Recommendations – Drugs

 


M-A: Decision-making authority during Tele-ICU care reduces mortality and length of stay.

5 Jul, 2021 | 01:18h | UTC

Decision-Making Authority During Tele-ICU Care Reduces Mortality and Length of Stay—A Systematic Review and Meta-Analysis – Critical Care Medicine (link to abstract – $ for full-text)

 


Systematic review: Border controls, restricted entry, quarantine essential for curbing COVID-19 and future pandemics.

1 Jul, 2021 | 09:53h | UTC

News release: Border controls, restricted entry, quarantine essential for curbing COVID-19 and future pandemics – British Medical Journal

Original study: Lessons from countries implementing find, test, trace, isolation and support policies in the rapid response of the COVID-19 pandemic: a systematic review – BMJ Open

Commentary: Strategies ID’d Than Can Interrupt Spread of Infectious Disease – HealthDay

 


Systematic Review: Cilostazol for intermittent claudication – “Cilostazol has been shown to improve walking distance in people with intermittent claudication. However, participants taking cilostazol had higher odds of experiencing headache”.

1 Jul, 2021 | 09:42h | UTC

Cilostazol for intermittent claudication – Cochrane Library

Summary: Cilostazol for peripheral arterial disease – Cochrane Library

 


M-A: Simultaneous use of hypertonic saline and IV furosemide for fluid overload – “Benefits of the HSS+Fx over Fx were observed across all examined outcomes in acute decompensated heart failure patients with fluid overload”.

1 Jul, 2021 | 09:41h | UTC

Simultaneous Use of Hypertonic Saline and IV Furosemide for Fluid Overload: A Systematic Review and Meta-Analysis – Critical Care Medicine (link to abstract – $ for full-text)

 


M-A: The utility of the rapid shallow breathing index in predicting successful extubation – “As a stand-alone test, the RSBI has moderate sensitivity and poor specificity for predicting extubation success”.

30 Jun, 2021 | 10:07h | UTC

The Utility of the Rapid Shallow Breathing Index in Predicting Successful Extubation: A Systematic Review and Meta-analysis – CHEST (link to abstract – $ for full-text)

 


Systematic review: the evidence behind robot-assisted abdominopelvic surgery – “there is currently no clear advantage with existing robotic platforms, which are costly and increase operative duration”.

29 Jun, 2021 | 09:55h | UTC

The Evidence Behind Robot-Assisted Abdominopelvic Surgery: A Systematic Review – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentary: Robotic Platforms Not Superior for Abdominopelvic Surgery – HealthDay

 


Systematic review: low‐dose oral misoprostol probably has many benefits over other methods for labor induction.

24 Jun, 2021 | 09:44h | UTC

Low‐dose oral misoprostol for induction of labour – Cochrane Library

 


Another meta-analysis supports aspirin withdrawal one to three months after percutaneous coronary intervention and continuation with P2Y12 inhibitor monotherapy.

18 Jun, 2021 | 08:22h | UTC

P2Y12 inhibitor monotherapy or dual antiplatelet therapy after coronary revascularisation: individual patient level meta-analysis of randomised controlled trials – The BMJ

Related: M-A: After an acute coronary syndrome treated with coronary stenting, dual antiplatelet therapy (DAPT) for 1 to 3 months followed by P2Y12 inhibitor monotherapy is associated with improved outcomes compared with traditional DAPT for 12 months.

 


M-A: Acute treatments for episodic migraine in adults.

18 Jun, 2021 | 08:18h | UTC

Acute Treatments for Episodic Migraine in Adults: A Systematic Review and Meta-analysis – JAMA (free for a limited period)

Editorial: Acute Treatment for Migraine: Contemporary Treatments and Future Directions (free for a limited period)

 

Commentary on Twitter (thread – click for more)

 


M-A: Extracorporeal membrane oxygenation for COVID-19.

16 Jun, 2021 | 08:22h | UTC

Extracorporeal membrane oxygenation for COVID-19: a systematic review and meta-analysis – Critical Care

 


M-A: Ibuprofen and other NSAIDs superior to codeine for managing outpatient postoperative pain.

15 Jun, 2021 | 08:55h | UTC

News release: Ibuprofen and other NSAIDs superior to codeine for managing outpatient postoperative pain – Canadian Medical Association Journal

Original Article: Managing postoperative pain in adult outpatients: a systematic review and meta-analysis comparing codeine with NSAIDs – Canadian Medical Association Journal

 


M-A: Among patients with kidney failure treated with dialysis, mineralocorticoid receptor antagonists reduce cardiovascular and all-cause mortality without increasing the risk of hyperkalemia.

15 Jun, 2021 | 08:53h | UTC

Efficacy and Safety of Mineralocorticoid Receptor Antagonists in Kidney Failure Patients Treated with Dialysis: A Systematic Review and Meta-Analysis – Clinical Journal of the American Society of Nephrology (link to abstract – $ for full-text)

 

Commentary on Twitter

 


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