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Systematic Reviews & Meta-Analysis

USPSTF Draft Statement: Insufficient evidence to recommend multivitamin supplements for the prevention of CVD or cancer. The statement also recommends against the use of beta-carotene (increases risk of CVD mortality and lung cancer) or vitamin E (clear evidence of no benefit)

5 May, 2021 | 08:30h | UTC

Draft Recommendation Statement: Vitamin, Mineral, and Multivitamin Supplementation to Prevent Cardiovascular Disease and Cancer – U.S. Preventive Services Task Force

Draft Evidence Review: Vitamin, Mineral, and Multivitamin Supplementation to Prevent Cardiovascular Disease and Cancer

 


[Preprint] Frequency of neurological manifestations in COVID-19: a systematic review and meta-analysis of 350 studies – up to one-third of COVID-19 patients analyzed in this review, 89% of whom were hospitalized, experienced at least one neurological manifestation

4 May, 2021 | 08:44h | UTC

Frequency of neurological manifestations in COVID-19: a systematic review and meta-analysis of 350 studies – medRxiv

Commentary: Study finds one-third of COVID-19 patients experience neurological symptoms – News Medical

 


Systematic review: Interventions for increasing solid organ donor registration

28 Apr, 2021 | 08:11h | UTC

Interventions for increasing solid organ donor registration – Cochrane Library

Summary: Interventions for increasing solid organ donor registration – Cochrane Library

 


Systematic Review: Disease‐modifying treatments for primary autoimmune hemolytic anemia

28 Apr, 2021 | 08:09h | UTC

Disease‐modifying treatments for primary autoimmune haemolytic anaemia – Cochrane Library

Summary: Treatment for primary autoimmune haemolytic anaemia – Cochrane Library

 


M-A: Effectiveness of intrapartum fetal surveillance to improve maternal and neonatal outcomes – “none of the newer surveillance methods seem to significantly reduce emergency cesarean deliveries in labor or neonatal morbidity compared with using simple intermittent auscultation of the fetal heart”

28 Apr, 2021 | 08:08h | UTC

Effectiveness of intrapartum fetal surveillance to improve maternal and neonatal outcomes: a systematic review and network meta-analysis – Canadian Medical Association Journal

 


M-A: Helicobacter pylori eradication therapy to prevent gastric cancer – H. pylori eradication may reduce the incidence of gastric cancer in healthy individuals in East Asian countries

27 Apr, 2021 | 09:21h | UTC

Helicobacter pylori eradication therapy to prevent gastric cancer: systematic review and meta-analysis (link to abstract – $ for full-text – free article here)

 


M-A: Comparative Efficacy of 6 Topical Pharmacological Agents for Preventive Interventions of Postoperative Sore Throat After Tracheal Intubation

27 Apr, 2021 | 09:13h | UTC

Comparative Efficacy of 6 Topical Pharmacological Agents for Preventive Interventions of Postoperative Sore Throat After Tracheal Intubation: A Systematic Review and Network Meta-analysis – Anesthesia & Analgesia

 


M-A: Lidocaine lubricant jelly does not reduce pain perception during female urethral catheterization

27 Apr, 2021 | 09:11h | UTC

Lidocaine lubricant jelly does not reduce pain perception during female urethral catheterization: A systematic review with meta‐analysis and trial sequential analysis – The International Journal of Clinical Practice (link to abstract – $ for full-text)

 


Systematic review: Surgical or radiological treatment for varicoceles in subfertile men

27 Apr, 2021 | 09:09h | UTC

Surgical or radiological treatment for varicoceles in subfertile men – Cochrane Library

 


Systematic Review: Dopamine agonists for preventing ovarian hyperstimulation syndrome

27 Apr, 2021 | 09:08h | UTC

Dopamine agonists for preventing ovarian hyperstimulation syndrome – Cochrane Library

Summary: Can dopamine agonists prevent ovarian hyperstimulation syndrome in women undergoing fertility treatment with IVF or ICSI? – Cochrane Library

 


Systematic review shows there is insufficient evidence on the best approaches to stop long‐term antidepressant use – “Future studies should distinguish carefully between relapse and withdrawal symptoms”

23 Apr, 2021 | 08:19h | UTC

Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety disorders in adults – Cochrane Library

Author interview: Stopping long-term antidepressants in people with depression or anxiety – Cochrane Library

Commentary: ‘Urgent’ need for more evidence on safely stopping antidepressants, say experts – Metro

“Future studies should distinguish carefully between relapse and withdrawal symptoms and follow emerging guidance to use taper schemes of many weeks or months (or longer for long-term users) down to very low doses before stopping. Such studies would give us a clearer idea of the ability of antidepressants to prevent relapse.”

 

Commentary on Twitter (thread – click for more)

 


Systematic Review: PARP (Poly ADP‐Ribose Polymerase) inhibitors for locally advanced or metastatic breast cancer

23 Apr, 2021 | 08:16h | UTC

PARP (Poly ADP‐Ribose Polymerase) inhibitors for locally advanced or metastatic breast cancer – Cochrane Library

Summary: PARP inhibitors for locally advanced or metastatic breast cancer – Cochrane Library

 


Systematic review: Venoarterial Extracorporeal Membrane Oxygenation in Massive Pulmonary Embolism-Related Cardiac Arrest

22 Apr, 2021 | 08:18h | UTC

Venoarterial Extracorporeal Membrane Oxygenation in Massive Pulmonary Embolism-Related Cardiac Arrest: A Systematic Review – Critical Care Medicine

Summary: VA ECMO for Massive PE + Cardiac Arrest – Journal Feed

 


M-A: Aspirin alone better than dual antiplatelet therapy after transcatheter aortic valve implantation

22 Apr, 2021 | 08:20h | UTC

Aspirin Alone Versus Dual Antiplatelet Therapy After Transcatheter Aortic Valve Implantation: A Systematic Review and Patient‐Level Meta‐Analysis – Journal of the American Heart Association

 


Maternal, Fetal, and Child Outcomes of Mental Health Treatments in Women: A Systematic Review of Perinatal Pharmacologic Interventions

22 Apr, 2021 | 08:19h | UTC

Maternal, Fetal, and Child Outcomes of Mental Health Treatments in Women: A Systematic Review of Perinatal Pharmacologic Interventions – Agency for Healthcare Research and Quality

See also: Final Report AND Evidence Summary

 


Systematic review: Thrombolytic therapy for acute massive or submassive pulmonary embolism

21 Apr, 2021 | 06:20h | UTC

Thrombolytic therapy for pulmonary embolism – Cochrane Library

Summary: Drugs to dissolve pulmonary embolism (blood clot in the lungs) – Cochrane Library

 


M-A: Corticosteroids in COVID-19 and non-COVID-19 ARDS

20 Apr, 2021 | 06:11h | UTC

Corticosteroids in COVID-19 and non-COVID-19 ARDS: a systematic review and meta-analysis – Intensive Care Medicine

 


M-A: Progestogens for preventing miscarriage

21 Apr, 2021 | 06:22h | UTC

Progestogens for preventing miscarriage: a network meta‐analysis – Cochrane Library

Summary: Are progestogen treatments effective in preventing miscarriage? – Cochrane Library

Related Meta-analysis: Evaluating Progestogens for Preventing Preterm birth International Collaborative (EPPPIC): meta-analysis of individual participant data from randomised controlled trials – The Lancet (link to abstract – $ for full-text)

 


M-A: Portal venous system thrombosis after bariatric surgery

21 Apr, 2021 | 06:16h | UTC

Portal venous system thrombosis after bariatric surgery: A systematic review and meta-analysis – Surgery (link to abstract – $ for full-text)

 


M-A: Diagnostic performance of different sampling approaches for SARS-CoV-2 RT-PCR testing

20 Apr, 2021 | 06:09h | UTC

Diagnostic performance of different sampling approaches for SARS-CoV-2 RT-PCR testing: a systematic review and meta-analysis – The Lancet Infectious Diseases

Commentary: Beyond COVID-19—will self-sampling and testing become the norm? – The Lancet Infectious Diseases

Related Meta-analysis: Saliva and nasopharyngeal swab nucleic acid amplification have similar diagnostic accuracy for the detection of SARS-CoV-2 AND Saliva vs. nasopharyngeal swabs equally sensitive for Covid-19 diagnosis

 


Therapies for Clinically Localized Prostate Cancer: A Comparative Effectiveness Review

18 Apr, 2021 | 21:16h | UTC

Therapies for Clinically Localized Prostate Cancer: A Comparative Effectiveness Review – The Journal of Urology

Commentary: Review: For many men with prostate cancer, surgery risks outweigh potential benefits – U.S. Department of Veteran Affairs

 


M-A: Nonantibiotic Strategies for the Prevention of Infectious Complications following Prostate Biopsy

18 Apr, 2021 | 21:14h | UTC

Nonantibiotic Strategies for the Prevention of Infectious Complications following Prostate Biopsy: A Systematic Review and Meta-Analysis – The Journal of Urology

 


M-A: Long-acting injectable vs. oral antipsychotics for the maintenance treatment of schizophrenia

15 Apr, 2021 | 06:31h | UTC

Long-acting injectable versus oral antipsychotics for the maintenance treatment of schizophrenia: a systematic review and comparative meta-analysis of randomised, cohort, and pre–post studies – The Lancet Psychiatry

 

Commentary on Twitter

 


M-A: Treatment with hydroxychloroquine is associated with increased mortality in COVID-19 patients

16 Apr, 2021 | 06:30h | UTC

Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19 from an international collaborative meta-analysis of randomized trials – Nature Communications

 

Commentaries on Twitter

 


M-A: Chemotherapy and radiotherapy in locally advanced head and neck cancer

15 Apr, 2021 | 06:29h | UTC

Chemotherapy and radiotherapy in locally advanced head and neck cancer: an individual patient data network meta-analysis – The Lancet Oncology

 

Commentary on Twitter

 


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