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Systematic Reviews & Meta-analysis

Degree of Myopia and Glaucoma Risk: A Dose-Response Meta-Analysis.

22 Oct, 2021 | 10:17h | UTC

Degree of Myopia and Glaucoma Risk: A Dose-Response Meta-Analysis – American Journal of Ophthalmology

 


Systematic Review: anti-interleukin-13 or anti-interleukin-4 agents may be appropriate for adults with moderate-to-severe uncontrolled asthma who have not responded to other treatments.

20 Oct, 2021 | 10:19h | UTC

Anti‐interleukin‐13 and anti‐interleukin‐4 agents versus placebo, anti‐interleukin‐5 or anti‐immunoglobulin‐E agents, for people with asthma – Cochrane Library

Summary: Anti-interleukin-13 or anti-interleukin-4 agents versus placebo, anti-interleukin-5 or anti-immunoglobulin-E agents, for children and adults with asthma – Cochrane Library

 

Commentary on Twitter (thread – click for more)

 


Systematic Review: Colchicine for the treatment of COVID‐19 – not beneficial for hospitalized patients; inconclusive evidence for the treatment of non-hospitalized patients, “probably slightly reduces the need for hospitalization or death within 28 days compared to placebo”.

19 Oct, 2021 | 10:13h | UTC

Colchicine for the treatment of COVID‐19 – Cochrane Library

Related:

[Preprint] PRINCIPLE RCT: Colchicine does not improve time to recovery in outpatients with Covid-19 at higher risk of complications.

COLCORONA RCT: Colchicine for community-treated patients with COVID-19 – findings suggest it may lower death and hospital admission rates, but further studies are required.

[Preprint] RECOVERY Trial: Colchicine does not improve outcomes in patients admitted to hospital with COVID-19.

 

Commentary on Twitter

 


Systematic Review: Calcium channel blockers versus other classes of drugs for hypertension – “there is moderate certainty evidence that diuretics reduce major cardiovascular events and congestive heart failure more than CCBs”.

19 Oct, 2021 | 08:56h | UTC

Summary: Calcium channel blockers versus other classes of drugs for hypertension – Cochrane Library

Original Study: Calcium channel blockers versus other classes of drugs for hypertension – Cochrane Library

 

Commentary on Twitter

 


M-A: Effectiveness and safety of non-steroidal anti-inflammatory drugs and opioid treatment for knee and hip osteoarthritis – although Etoricoxib 60 mg/day and diclofenac 150 mg/day seem to be most effective treatments, topical diclofenac 70-81 mg/day is safer and should be considered as first line treatment.

17 Oct, 2021 | 21:14h | UTC

Effectiveness and safety of non-steroidal anti-inflammatory drugs and opioid treatment for knee and hip osteoarthritis: network meta-analysis – The BMJ

News release: Topical pain-killers more effective, safer than opioids for knee osteoarthritis pain – St. Michael’s Hospital

Commentary: Network meta-analysis compares analgesic regimens for osteoarthritis – medwire News

 

Commentary on Twitter

 


M-A: Psychosocial and psychological interventions for relapse prevention in schizophrenia.

17 Oct, 2021 | 21:12h | UTC

Psychosocial and psychological interventions for relapse prevention in schizophrenia: a systematic review and network meta-analysis – The Lancet Psychiatry

 

Commentary on Twitter

 


Serious injury risk higher for horse riding than for football, motor racing, or skiing – “Chest most common site of injury, but head and neck injuries most lethal”.

17 Oct, 2021 | 21:08h | UTC

News release: Serious injury risk higher for horse riding than for football, motor racing, or skiing – BMJ

Original study: Hearing hoofbeats? Think head and neck trauma: a 10-year NTDB analysis of equestrian-related trauma in the USA – Trauma Surgery & Acute Care Open

Commentary: Horse Riding More Dangerous Than Skiis And Motorcycles, Injury Data Reveal – Science Alert

 


Systematic Review: There is not enough evidence from randomized trials to inform about the effects of additional antihypertensive drugs in patients with hypertension‐induced left ventricular hypertrophy.

15 Oct, 2021 | 02:20h | UTC

Pharmacotherapy for hypertension‐induced left ventricular hypertrophy – Cochrane Library

Summary: What are the main benefits and risks of drugs for reducing blood pressure in the treatment of people with thickening of the heart muscle caused by high blood pressure? – Cochrane Library

 

Commentary on Twitter

 


M-A: Outcomes after transcatheter aortic valve replacement in bicuspid versus tricuspid anatomy – device success and 1-year survival rates are similar, but patients with bicuspid valves have a higher risk for periprocedural complications.

14 Oct, 2021 | 09:51h | UTC

Outcomes After Transcatheter Aortic Valve Replacement in Bicuspid Versus Tricuspid Anatomy: A Systematic Review and Meta-Analysis – JACC: Cardiovascular Interventions

 


Systematic Review: Direct oral anticoagulants (DOACs) may be beneficial for people being treated for cancer who have no therapeutic or prophylactic indication for anticoagulation.

14 Oct, 2021 | 09:44h | UTC

Oral anticoagulation in people with cancer who have no therapeutic or prophylactic indication for anticoagulation – Cochrane Library

 


Systematic Review: Ultrasound guidance for arterial (other than femoral) catheterization in adults may improve first attempt and overall success rates compared to palpation.

14 Oct, 2021 | 09:41h | UTC

Ultrasound guidance for arterial (other than femoral) catheterisation in adults – Cochrane Library

 


M-A: Omega-3 fatty acids supplementation is associated with increased risk of atrial fibrillation.

13 Oct, 2021 | 01:27h | UTC

Effect of Long-Term Marine Omega-3 Fatty Acids Supplementation on the Risk of Atrial Fibrillation in Randomized Controlled Trials of Cardiovascular Outcomes: A Systematic Review and Meta-Analysis – Circulation (link to abstract – $ for full-text)

Related:

M-A: Omega-3 fatty acids supplementation increases the risk of atrial fibrillation in patients with lipid disorders.

More data suggests no cardiovascular benefit from Omega-3 supplementation – secondary analysis of STRENGHT trial did not show an association between achieved Omega-3 fatty acid levels and major adverse cardiovascular outcomes in patients with high cardiovascular risk.

RCT: Omega-3 supplements do not reduce cardiovascular events in elderly patients after myocardial infarction

#AHA20 – Randomized trial: High-dose Omega-3 fatty acids did not reduce the risk of cardiac events in patients at high cardiovascular risk

Meta-Analysis of Randomized Trials: Little Benefit from Omega-3 Intake to Reduce Cardiovascular Disease Risk

 

Commentary on Twitter

 


M-A: Accuracy of the Patient Health Questionnaire-9 for screening to detect major depression.

10 Oct, 2021 | 21:34h | UTC

Accuracy of the Patient Health Questionnaire-9 for screening to detect major depression: updated systematic review and individual participant data meta-analysis – The BMJ

See calculator: PHQ-9 (Patient Health Questionnaire-9)

 

Commentary on Twitter

 


Age at onset of mental disorders worldwide: large-scale meta-analysis of 192 epidemiological studies.

10 Oct, 2021 | 21:31h | UTC

Age at onset of mental disorders worldwide: large-scale meta-analysis of 192 epidemiological studies – Molecular Psychiatry

Commentary: Age at onset of mental disorders: global meta-analysis provides data for targeting effective interventions – The Mental Elf

 


Systematic review: Pretomanid for tuberculosis.

6 Oct, 2021 | 08:51h | UTC

Pretomanid for tuberculosis: a systematic review – Clinical Microbiology and Infection

Related:

Summary | WHO recommendations on the treatment of drug-resistant tuberculosis, 2020 update.

WHO announces updates on new molecular assays for the diagnosis of tuberculosis (TB) and drug resistance

WHO announces updated definitions of extensively drug-resistant tuberculosis

 


RCT: Early computed tomography coronary angiography in patients with suspected acute coronary syndrome did not improve one year clinical outcomes.

3 Oct, 2021 | 22:35h | UTC

Early computed tomography coronary angiography in patients with suspected acute coronary syndrome: randomised controlled trial – The BMJ

 

Commentary on Twitter

 


Systematic Review: Is exercise an effective therapy to treat long-lasting low back pain?

3 Oct, 2021 | 22:32h | UTC

Summary: Is exercise an effective therapy to treat long-lasting low back pain? – Cochrane Library

Original Study: Exercise therapy for chronic low back pain – Cochrane Library

 

Commentary on Twitter

 


Systematic Review: Does testing for cancer in people with unprovoked blood clots in the legs and lungs reduce cancer- and blood clot-related death and illness?

3 Oct, 2021 | 22:33h | UTC

Summary: Does testing for cancer in people with unprovoked blood clots in the legs and lungs reduce cancer- and blood clot-related death and illness? – Cochrane Library

Original article: Effect of testing for cancer on cancer‐ or venous thromboembolism (VTE)‐related mortality and morbidity in people with unprovoked VTE – Cochrane Library

 


Biomarkers of dairy fat intake, incident cardiovascular disease, and all-cause mortality: A cohort study, systematic review, and meta-analysis.

1 Oct, 2021 | 10:17h | UTC

Biomarkers of dairy fat intake, incident cardiovascular disease, and all-cause mortality: A cohort study, systematic review, and meta-analysis – PLOS Medicine

Commentaries:

Sticking to low-fat dairy may not be the only heart healthy option, study shows – George Institute for Global Health

Expert reaction to cohort study and review on biomarkers of dairy fat intake, CVD and all-cause mortality – Science Media Centre

People who eat more dairy fat have lower risk of heart disease, study suggests – CNN

 


Systematic review: Can non-pharmacological measures prevent or reduce Covid-19 (SARS-CoV-2) infections in long term care facilities?

28 Sep, 2021 | 09:47h | UTC

Commentary: Can non-pharmacological measures prevent or reduce Covid-19 (SARS-CoV-2) infections in long term care facilities? – Cochrane Library

Original study: Non‐pharmacological measures implemented in the setting of long‐term care facilities to prevent SARS‐CoV‐2 infections and their consequences: a rapid review – Cochrane Library

 


M-A of randomized trials: Efficacy of exercise combined with standard treatment for depression compared to standard treatment alone.

28 Sep, 2021 | 08:55h | UTC

Efficacy of exercise combined with standard treatment for depression compared to standard treatment alone: A systematic review and meta-analysis of randomized controlled trials – Journal of Affective Disorders

 

Commentary on Twitter

 


Systematic review: Instruments for assisted vaginal birth.

26 Sep, 2021 | 21:35h | UTC

Instruments for assisted vaginal birth – Cochrane Library

Summary: Instruments for assisted vaginal birth – Cochrane Library

 


Systematic Review: Non‐invasive positive airway pressure therapy for improving erectile dysfunction in men with obstructive sleep apnea.

26 Sep, 2021 | 21:36h | UTC

Non‐invasive positive airway pressure therapy for improving erectile dysfunction in men with obstructive sleep apnoea – Cochrane Library

Summary: Non-invasive positive airway pressure therapy to improve erectile dysfunction in men with obstructive sleep apnoea – Cochrane Library

 


M-A: Treatment options for progression or recurrence of glioblastoma.

26 Sep, 2021 | 21:34h | UTC

Treatment options for progression or recurrence of glioblastoma: a network meta‐analysis – Cochrane Library

Summary: Treatment options for people with recurrent and progressive glioblastoma – Cochrane Library

 


Cochrane Special Collection | De-implementation of low-value health care: resource prioritization in the COVID-19 pandemic era.

23 Sep, 2021 | 10:13h | UTC

De-implementation of low-value health care: resource prioritization in the COVID-19 pandemic era – Cochrane Library

Editorial: Making wise choices about low‐value health care in the COVID‐19 pandemic – Cochrane Library

Commentary: Choosing health care wisely when resources are scarce – Evidently Cochrane

 

Commentaries on Twitter

 


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