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Covid-19

Opinion: COVID-19 will continue but the end of the pandemic is near.

21 Jan, 2022 | 10:16h | UTC

COVID-19 will continue but the end of the pandemic is near – The Lancet

 

Commentary on Twitter

 

Opinion: Now that science has defanged Covid, it’s time to get on with our lives.

21 Jan, 2022 | 10:14h | UTC

Now that science has defanged Covid, it’s time to get on with our lives – The Guardian

See also: A National Strategy for the “New Normal” of Life With COVID – JAMA

 

Europe considers new COVID-19 strategy: Accepting the virus.

21 Jan, 2022 | 10:13h | UTC

Europe considers new COVID-19 strategy: Accepting the virus – Associated Press

 

RCT: Immunogenicity and reactogenicity of different vaccine boosters after a first J&J vaccine.

21 Jan, 2022 | 10:12h | UTC

Immunogenicity and Reactogenicity of Vaccine Boosters after Ad26.COV2.S Priming – New England Journal of Medicine

 

Commentary on Twitter

 

Perspective: Nervous system consequences of COVID-19.

21 Jan, 2022 | 10:10h | UTC

Nervous system consequences of COVID-19 – Science

Related:

Perspective | Post-acute neurological consequences of COVID-19: an unequal burden – “COVID-19 and its neurological consequences particularly burden marginalized communities, and so can only be effectively treated by advancing health equity”.

Review: Counting the neurological cost of COVID-19.

Infection with Covid-19 carries a much higher risk of developing neurological complications than Covid-19 vaccines.

M-A: Frequency of Neurologic Manifestations in COVID-19 – up to one-third of patients (89% hospitalized) experienced at least one neurological manifestation.

Neurological Effects of COVID-19 in Children.

Cohort study: Neurological manifestations of SARS-CoV-2 infection in hospitalized children and adolescents in the UK – “around 1 in 20 of children hospitalized with COVID-19 develop brain or nerve complications linked to the viral infection”.

International Registry: Ischemic and hemorrhagic stroke among critically ill patients with Covid-19.

Short review: Neurological complications of COVID-19.

2 new meta-analysis detail neurologic and psychiatric conditions in COVID-19.

M-A: Encephalitis as Neurological Complication of COVID‐19.

Large study finds 1 in 3 Covid-19 survivors have subsequent mental health and neurological conditionsEight out of ten people hospitalized with COVID-19 develop neurological problems – the most common self-reported symptoms included headache (37%) and anosmia or ageusia (26%).

[Preprint] Frequency of neurological manifestations in COVID-19: a systematic review and meta-analysis of 350 studies – up to one-third of COVID-19 patients analyzed in this review, 89% of whom were hospitalized, experienced at least one neurological manifestation

 

Commentary on Twitter

 

Review: Postdischarge Evaluation for Individuals Hospitalized with COVID-19.

21 Jan, 2022 | 10:08h | UTC

Postdischarge Evaluation for Individuals Hospitalized with COVID-19 – Southern Medical Journal

 

[Preprint] COVID infection severity in children under 5 years old before and after Omicron emergence in the US.

21 Jan, 2022 | 10:04h | UTC

COVID infection severity in children under 5 years old before and after Omicron emergence in the US – medRxiv

Commentary: SARS-CoV-2 Omicron infections milder in children compared to Delta – News Medical

 

WHO’s Emergencies expert group re-asserts stance against covid ‘vaccine passports’ for international travel.

21 Jan, 2022 | 10:02h | UTC

WHO’s Emergencies Expert Group Re-Asserts Stance Against COVID ‘Vaccine Passports’ for International Travel – Health Policy Watch

 

Editorial | Covid-19 vaccines and treatments: we must have raw data, now.

21 Jan, 2022 | 10:00h | UTC

Covid-19 vaccines and treatments: we must have raw data, now – The BMJ

News Release: Editors call for covid-19 vaccine and treatment data to be available for public scrutiny – The BMJ

 

Editorial | Long covid in children and adolescents – “Risk appears low, but many questions remain”.

21 Jan, 2022 | 09:58h | UTC

Long covid in children and adolescents – The BMJ

Related:

M-A: Persistent symptoms following SARS-CoV-2 infection among children and young people – “Higher study quality was associated with lower prevalence of all symptoms, except loss of smell and cognitive symptoms”.

Review: Long COVID symptoms in children rarely persist beyond three months.

Cohort study: long term follow-up showed most patients with post–COVID-19 Multisystem Inflammatory Syndrome in Children had good outcomes with no significant medium- or long-term sequelae.

Long COVID: the physical and mental health of children and non-hospitalized young people after SARS-CoV-2 infection – one in seven children may still have symptoms 15 weeks after infection.

Do kids get long COVID? And how often? A pediatrician looks at the data – Children also get Long Covid, but much less often than adults.

Illness duration and symptom profile in symptomatic school-aged children tested for SARS-CoV-2 – “Only 25 (1.8%) of 1379 children experienced symptoms for at least 56 days.”

Long-term Symptoms After SARS-CoV-2 Infection in Children and Adolescents – “This study found a low prevalence of symptoms compatible with long COVID in a randomly selected cohort of children assessed 6 months after serologic testing”.

Study shows low incidence of post-acute COVID-19 symptoms (“Long Covid”) in children after mild disease

Cohort study: Risk factors for long covid in previously hospitalized children.

M-A: More than 50 long-term effects of COVID-19.

 

Commentary on Twitter

 

Booster longevity: Data reveals how long a third shot protects.

20 Jan, 2022 | 09:33h | UTC

Booster longevity: Data reveals how long a third shot protects – NPR

Original Report: SARS-CoV-2 variants of concern and variants under investigation in England – U.K. Health Security Agency

 

A populational-based retrospective cohort study in Qatar showed a reduced risk of Covid-19 breakthrough infections with the Moderna vs. the Pfizer–BioNTech vaccine.

20 Jan, 2022 | 09:30h | UTC

Effectiveness of mRNA-1273 and BNT162b2 Vaccines in Qatar – New England Journal of Medicine

 

Commentary on Twitter

 

Milder disease with Omicron: is it the virus or the pre-existing immunity?

20 Jan, 2022 | 09:28h | UTC

Milder disease with Omicron: is it the virus or the pre-existing immunity? – Nature Reviews Immunology

 

How does Omicron spread so fast? A high viral load isn’t the answer – “Data on viral levels point to immune evasion as a cause of the variant’s transmissibility”.

20 Jan, 2022 | 09:27h | UTC

How does Omicron spread so fast? A high viral load isn’t the answer – Nature

 

Heart function recovered quickly in children with COVID-19-related multisystem inflammatory syndrome (MIS-C).

20 Jan, 2022 | 09:26h | UTC

News Release: Heart function recovered quickly in children with COVID-19-related MIS-C condition – American Heart Association

Original Study: Longitudinal Assessment of Cardiac Outcomes of Multisystem Inflammatory Syndrome in Children Associated With COVID‐19 Infections – Journal of the American Heart Association

 

Short Review: Fluvoxamine for symptomatic outpatients with COVID-19.

20 Jan, 2022 | 09:25h | UTC

Fluvoxamine for symptomatic outpatients with COVID-19 – Canadian Medical Association Journal

Related:

Fluvoxamine for Covid-19: What Prescribers and Pharmacists Need to Know.

Fluvoxamine for the early treatment of SARS-CoV-2 Infection: a review of current evidence.

RCT: Early treatment with fluvoxamine reduced the risk of emergency care and hospitalization among patients with COVID-19.

[Preprint] RCT: Fluvoxamine reduced the risk for ER visits and hospitalization among patients with Covid-19.

Opinion | Could this be our first effective, inexpensive, widely available outpatient treatment for COVID-19? (It’s fluvoxamine).

Preliminary study shows fluvoxamine may reduce clinical deterioration in outpatients with symptomatic COVID-19

 

A large observational study showed people with immune disfunction (HIV, solid organ transplant, rheumatoid arthritis) were at increased risk of breakthrough Covid-19 infection after vaccination.

20 Jan, 2022 | 09:24h | UTC

Association Between Immune Dysfunction and COVID-19 Breakthrough Infection After SARS-CoV-2 Vaccination in the US – JAMA Internal Medicine

 

After Omicron, we could use a break. We may just get it.

20 Jan, 2022 | 09:21h | UTC

After Omicron, we could use a break. We may just get it – STAT

 

10 lessons I’ve learned from the Covid–19 pandemic.

20 Jan, 2022 | 09:21h | UTC

10 lessons I’ve learned from the Covid–19 pandemic – STAT

 

Covid pandemic ‘nowhere near over,’ WHO says.

20 Jan, 2022 | 09:18h | UTC

Covid pandemic ‘nowhere near over,’ WHO says – CNN

 

Systematic Review: School closures during social lockdown and mental health, health behaviors, and well-being among children and adolescents during the first Covid-19 wave.

19 Jan, 2022 | 09:00h | UTC

School Closures During Social Lockdown and Mental Health, Health Behaviors, and Well-being Among Children and Adolescents During the First COVID-19 Wave: A Systematic Review – JAMA Pediatrics

Editorial: Pandemic Recovery for Children—Beyond Reopening Schools – JAMA Pediatrics

Commentary: More Behavioral Issues Reported in Children When School Is Virtual – Psychiatric News Alert

Related:

M-A: Child and youth mental health problems have doubled during COVID-19.

Adolescents’ recreational screen time doubled during pandemic, affecting mental health.

More data on the harmful effects of the COVID-19 pandemic on the mental health of adolescents.

COVID has caused ‘mass trauma,’ worsening mental health globally.

COVID’s mental-health toll: how scientists are tracking a surge in depression

CDC Report: Mental health-related emergency department visits among children aged under 18 years raised during the COVID-19 Pandemic

WHO: COVID-19 disrupting mental health services in most countries

 

Commentary on Twitter (thread – click for more)

 

COVID-19 testing infographics.

19 Jan, 2022 | 08:59h | UTC

COVID-19 testing infographics – British Society for Immunology

 

Commentary on Twitter

 

The pandemic’s true death toll: millions more than official counts.

19 Jan, 2022 | 08:57h | UTC

The pandemic’s true death toll: millions more than official counts – Nature

Related:

We can be confident there have been far more than 5 million global Covid deaths – “Estimating ‘excess’ fatalities, a more robust analysis method, puts the pandemic’s grim toll between 10m and 19m people”.

Global Covid-19 deaths surpass five million.

Effects of the Covid-19 pandemic on life expectancy and premature mortality in 2020 – this time series analysis showed there were more than 28 million excess years of life lost in 2020 in 31 countries.

Under-reporting of deaths limits our understanding of true burden of covid-19.

Study shows COVID-19 has caused the biggest decrease in life expectancy since World War II.

Just how do deaths due to COVID-19 stack up?

Tracking excess mortality across countries during the COVID-19 pandemic with the World Mortality Dataset.

Exploring the gap between excess mortality and COVID-19 deaths in 67 countries.

Report: Three new estimates of India’s all-cause excess mortality during the COVID-19 Pandemic – pandemic death toll estimated to be between 3.4 million and 4.9 million excess deaths.

COVID-19 has caused 6.9 million deaths globally, more than double what official reports show

 

Commentary on Twitter

 

Placebo effect accounts for more than two-thirds of COVID-19 vaccine adverse events, researchers find.

19 Jan, 2022 | 08:53h | UTC

News Release: Placebo effect accounts for more than two-thirds of COVID-19 vaccine adverse events, researchers find – Beth Israel Deaconess Medical Center

Original Study: Frequency of Adverse Events in the Placebo Arms of COVID-19 Vaccine Trials: A Systematic Review and Meta-analysis – JAMA Network Open

Commentary: ‘Nocebo effect’: two-thirds of Covid jab reactions not caused by vaccine, study suggests – The Guardian

 

RCT: In non–critically ill hospitalized patients with COVID-19, the use of a P2Y12 Inhibitor (ticagrelor in 63% of patients and clopidogrel in 37%) in addition to a therapeutic dose of heparin did not improve survival free of organ support compared to therapeutic heparin alone.

19 Jan, 2022 | 08:56h | UTC

Effect of P2Y12 Inhibitors on Survival Free of Organ Support Among Non–Critically Ill Hospitalized Patients With COVID-19: A Randomized Clinical Trial – JAMA

Editorial: Antiplatelet Therapy in Patients With COVID-19—More Is Less? – JAMA

Commentary: Adding a P2Y12 Inhibitor Does Not Improve Outcomes in COVID-19 – HealthDay

 

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