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Covid-19

Multinational Study | No correlation between Covid-19 and onset of type 1 diabetes in children

8 Aug, 2023 | 13:32h | UTC

SARS-CoV-2 — No Increased Islet Autoimmunity or Type 1 Diabetes in Teens – New England Journal of Medicine

 


Opinion | Bad science needs to be called out: the medical profession loses trust when bad studies are used to promote policy

1 Aug, 2023 | 14:29h | UTC

Bad Science Needs to Be Called Out – Sensible Medicine

Related: Did Republicans die more during the pandemic bc they didn’t get the vax? – By Dr. Vinay Prassad

Original Study: Excess Death Rates for Republican and Democratic Registered Voters in Florida and Ohio During the COVID-19 Pandemic – JAMA Internal Medicine

 


Critical Appraisal | Did Republicans die more during the pandemic bc they didn’t get the vax?

1 Aug, 2023 | 14:28h | UTC

Did Republicans die more during the pandemic bc they didn’t get the vax? – By Dr. Vinay Prassad

Related: Bad Science Needs to Be Called Out – Sensible Medicine

Original Study: Excess Death Rates for Republican and Democratic Registered Voters in Florida and Ohio During the COVID-19 Pandemic – JAMA Internal Medicine

 


Opinion Video | Critical analysis of the data behind Covid-19 booster shots

31 Jul, 2023 | 14:40h | UTC

“FLAWED Booster data was used by FDA for Mass Vax Campaign & We PROVE it in our new PAPER” – YouTube Video by Dr Vinay Prassad

Original Publication: Correspondence | Potential “healthy vaccinee bias” in a study of BNT162b2 vaccine against Covid-19

 


Mitigating neurological, cognitive, and psychiatric sequelae of COVID-19-related critical illness

26 Jul, 2023 | 13:28h | UTC

Mitigating neurological, cognitive, and psychiatric sequelae of COVID-19-related critical illness – The Lancet Respiratory Medicine

 


Correspondence | Potential “healthy vaccinee bias” in a study of BNT162b2 vaccine against Covid-19

21 Jul, 2023 | 13:43h | UTC

Potential “Healthy Vaccinee Bias” in a Study of BNT162b2 Vaccine against Covid-19 – New England Journal of Medicine

 

Commentary from the author on Twitter (thread – click for more)

 


Review | Post-COVID Conditions

7 Jul, 2023 | 16:21h | UTC

Post-COVID Conditions – Mayo Clinic Proceedings

 


Consensus Statement 2023 Update | Timing of elective surgery and risk assessment after SARS-CoV-2 infection

30 Jun, 2023 | 15:00h | UTC

Timing of elective surgery and risk assessment after SARS-CoV-2 infection: 2023 update – Anaesthesia

 

Commentary on Twitter

 


Review | Breathing difficulties after covid-19: a guide for primary care

29 Jun, 2023 | 14:04h | UTC

Breathing difficulties after covid-19: a guide for primary care – The BMJ

 


Opinion | Strategic masking to protect patients from all respiratory viral infections

20 Jun, 2023 | 12:50h | UTC

Strategic Masking to Protect Patients from All Respiratory Viral Infections – New England Journal of Medicine (link to abstract – $ for full-text)

 


Perspective | Observational studies must be reformed before the next pandemic

15 Jun, 2023 | 15:12h | UTC

Observational studies must be reformed before the next pandemic – Nature Medicine

 


Review | Wastewater monitoring can anchor global disease surveillance systems

13 Jun, 2023 | 14:07h | UTC

Wastewater monitoring can anchor global disease surveillance systems – The Lancet Global Health

Related:

Use of Wastewater for Mpox Outbreak Surveillance in California – New England Journal of Medicine

Wastewater network infrastructure in public health: Applications and learnings from the COVID-19 pandemic – PLOS Global Public Health

Opinion: Wastewater analysis can be a powerful public health tool—if it’s done sensibly.

CDC unveils its latest weapon in Covid-19 detection: wastewater.

CDC Report: Using Wastewater Surveillance Data to Support the COVID-19 Response — United States, 2020–2021.

Rapid, large-scale wastewater surveillance and automated reporting system enabled early detection of nearly 85% of COVID-19 cases on a University campus.

[Preprint] Wastewater genomic testing can effectively track COVID-19 variants of concern.

Human Waste Could Be The Next Big Weapon in Controlling COVID-19 – TIME

Next steps for wastewater testing to help end this pandemic — and prevent the next one – STAT

Sewage sleuths helped an Arizona town beat back Covid-19. For wastewater epidemiology, that’s just the start – STAT

The myriad ways sewage surveillance is helping fight COVID around the world – Nature

Testing sewage can give school districts, campuses and businesses a heads-up on the spread of COVID-19 – The Conversation

It’s time to begin a national wastewater testing program for Covid-19 – STAT

Coronavirus: Testing sewage an ‘easy win’ – BBC

Development of wastewater pooled surveillance of SARS-CoV-2 from congregate living settings – high sensitivity, but unable to distinguish new infectious cases from persistent convalescent shedding.

 


2ry Analysis of a RCT | Metformin linked to 41% reduction in long COVID incidence in outpatient treatment

12 Jun, 2023 | 13:55h | UTC

Outpatient treatment of COVID-19 and incidence of post-COVID-19 condition over 10 months (COVID-OUT): a multicentre, randomised, quadruple-blind, parallel-group, phase 3 trial – The Lancet Infectious Diseases

News Release: Study shows metformin lowers the risk of getting long COVID – University of Minnesota Medical School

Commentary: Expert reaction to study on Metformin after testing positive for SARS-CoV-2 and risk of developing long COVID – Science Media Centre

 

Commentary on Twitter

 


RCT | P2Y12 inhibitors don’t improve outcomes in critically ill COVID-19 patients

31 May, 2023 | 14:13h | UTC

Effect of P2Y12 Inhibitors on Organ Support–Free Survival in Critically Ill Patients Hospitalized for COVID-19: A Randomized Clinical Trial – JAMA Network Open

See also: Visual Abstract

 


RCT | Rivaroxaban doesn’t reduce thrombotic events, hospitalization, or death in outpatients with COVID-19

15 May, 2023 | 13:19h | UTC

Summary: The PREVENT-HD trial, a double-blind, placebo-controlled randomized study, was conducted to evaluate the effectiveness of prophylactic anticoagulation in reducing venous and arterial thrombosis, hospitalization, and death in nonhospitalized patients with symptomatic COVID-19 and at least one thrombosis risk factor. The trial took place between August 2020 and April 2022 across 14 US integrated healthcare delivery networks, with 1,284 patients enrolled and randomly assigned to receive either 10 mg of oral rivaroxaban or placebo daily for 35 days.

However, the study was terminated prematurely due to enrollment challenges and lower-than-expected event rates. The primary efficacy outcome, a composite of various hazardous events, occurred in 3.4% of the rivaroxaban group and 3.0% of the placebo group, with no significant difference between the two groups (hazard ratio, 1.16 [95% CI, 0.63–2.15]; P=0.63). No critical-site or fatal bleeding was observed, and only one patient in the rivaroxaban group experienced a major bleed.

In conclusion, rivaroxaban prescribed for 35 days in nonhospitalized patients with symptomatic COVID-19 at risk for thrombosis does not appear to reduce the composite end point of venous and arterial thrombotic events, hospitalization, and death. The study’s premature termination and lower-than-expected event rates may limit the generalizability of these findings.

Article: Rivaroxaban for Prevention of Thrombotic Events, Hospitalization, and Death in Outpatients With COVID-19: A Randomized Clinical Trial – Circulation

 

Commentary on Twitter

 


RCT | Cognitive behavioral therapy proves effective for severe post-COVID-19 fatigue

15 May, 2023 | 13:16h | UTC

Efficacy of cognitive behavioral therapy targeting severe fatigue following COVID-19: results of a randomized controlled trial – Clinical Infectious Diseases

News Release: Cognitive behavioral therapy lessens post-viral fatigue after COVID-19 – Amsterdam UMC

 

Commentary on Twitter

 


M-A | Association of SARS-CoV-2 vaccination or infection with Bell palsy

10 May, 2023 | 16:03h | UTC

Association of SARS-CoV-2 Vaccination or Infection With Bell Palsy: A Systematic Review and Meta-analysis – JAMA Otolaryngology–Head & Neck Surgery

 


Review | Therapeutics for COVID-19

9 May, 2023 | 14:53h | UTC

Therapeutics for COVID-19 – Nature Microbiology

 

Commentary on Twitter

 


Cohort Study | Limited evidence linking COVID-19 vaccines to menstrual disturbance or postmenopausal bleeding

9 May, 2023 | 14:52h | UTC

Association between SARS-CoV-2 vaccination and healthcare contacts for menstrual disturbance and bleeding in women before and after menopause: nationwide, register based cohort study – The BMJ

News Release: New study finds no increased risk of menstrual changes after covid-19 vaccination – BMJ Newsroom

Commentary: Large study shows no changes to menstrual cycles after COVID vaccination – CIDRAP

Related:

A prospective study of the association between SARS-CoV-2 infection and COVID-19 vaccination with changes in usual menstrual cycle characteristics.

Editorial: Menstruation and Covid-19 vaccination.

 

Commentary on Twitter

 


WHO declares end to COVID-19 global health emergency

8 May, 2023 | 13:26h | UTC

WHO Declares End to COVID-19 Global Health Emergency – Health Policy Watch

WHO Statement: Statement on the fifteenth meeting of the International Health Regulations (2005) Emergency Committee regarding the coronavirus disease (COVID-19) pandemic – World Health Organization

 


RCT | BCG vaccine did not protect health care workers against Covid-19

4 May, 2023 | 13:56h | UTC

Randomized Trial of BCG Vaccine to Protect against Covid-19 in Health Care Workers – New England Journal of Medicine

Commentary: The BCG vaccine does not decrease the risk of COVID-19 in healthcare workers – News Medical

 

Commentary on Twitter

 


RCT | Oral fluvoxamine plus inhaled budesonide reduced hospitalizations in high-risk patients with early-onset COVID-19

24 Apr, 2023 | 13:51h | UTC

Oral Fluvoxamine With Inhaled Budesonide for Treatment of Early-Onset COVID-19: A Randomized Platform Trial – Annals of Internal Medicine

Commentary: Combination of fluvoxamine and inhaled budesonide reduces severe COVID-19 in high-risk outpatients – News Medical

 

Commentary on Twitter

 


RCT | Higher dose corticosteroids increase mortality in hypoxic COVID-19 patients on simple oxygen

24 Apr, 2023 | 13:55h | UTC

Higher dose corticosteroids in patients admitted to hospital with COVID-19 who are hypoxic but not requiring ventilatory support (RECOVERY): a randomised, controlled, open-label, platform trial – The Lancet

Editorial: Higher-dose dexamethasone for patients with COVID-19 and hypoxaemia? – The Lancet

Commentary: Higher-dose corticosteroids tied to 60% more deaths in low-oxygen COVID patients – CIDRAP

 

Commentary on Twitter (thread – click for more)

 


M-A | Glucocorticoids may increase mortality for hospitalized Covid-19 patients not receiving oxygen

19 Apr, 2023 | 13:24h | UTC

Meta-Analysis of Glucocorticoids for Covid-19 Patients Not Receiving Oxygen – NEJM Evidence

 

Commentary on Twitter (thread – click for more)

 


Opinion | Universal masking in health care settings: a pandemic strategy whose time has come and gone, for now

18 Apr, 2023 | 13:37h | UTC

Universal Masking in Health Care Settings: A Pandemic Strategy Whose Time Has Come and Gone, For Now – Annals of Internal Medicine

News Release: Healthcare epidemiologists and infectious diseases experts review changing context for masking in healthcare settings – Mass General Brigham

 


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