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Neurology

Podcast: Dementia Made Simple

20 Apr, 2021 | 05:21h | UTC

#268 Dementia Made Simple with Dr. Josh Uy – The Curbsiders

 


RCT: No benefit from second intravenous immunoglobulin dose in patients with Guillain-Barré syndrome with poor prognosis

18 Apr, 2021 | 21:21h | UTC

Second intravenous immunoglobulin dose in patients with Guillain-Barré syndrome with poor prognosis (SID-GBS): a double-blind, randomised, placebo-controlled trial – The Lancet Neurology (link to abstract – $ for full-text)

 


RCT: Comparison of Levetiracetam vs. Zonisamide vs. Lamotrigine for newly diagnosed focal epilepsy shows Lamotrigine should remain the first-line treatment option

12 Apr, 2021 | 00:51h | UTC

The SANAD II study of the effectiveness and cost-effectiveness of levetiracetam, zonisamide, or lamotrigine for newly diagnosed focal epilepsy: an open-label, non-inferiority, multicentre, phase 4, randomised controlled trial – The Lancet

Commentary: Clinical trials assess best first-line drugs for epilepsy – University of Liverpool

 


RCT: Comparison of Valproate vs. Levetiracetam for newly diagnosed generalized and unclassifiable epilepsy shows Valproate should remain the first-line treatment option

12 Apr, 2021 | 00:52h | UTC

The SANAD II study of the effectiveness and cost-effectiveness of valproate versus levetiracetam for newly diagnosed generalised and unclassifiable epilepsy: an open-label, non-inferiority, multicentre, phase 4, randomised controlled trial – The Lancet

Commentary: Clinical trials assess best first-line drugs for epilepsy – University of Liverpool

 


AHA/ASA Scientific Statement: Perioperative Neurological Evaluation and Management to Lower the Risk of Acute Stroke in Patients Undergoing Noncardiac, Nonneurological Surgery

12 Apr, 2021 | 00:50h | UTC

Perioperative Neurological Evaluation and Management to Lower the Risk of Acute Stroke in Patients Undergoing Noncardiac, Nonneurological Surgery: A Scientific Statement From the American Heart Association/American Stroke Association – Circulation

 

Commentary on Twitter

 


Concussion in para sport: the first position statement of the Concussion in Para Sport (CIPS) Group

12 Apr, 2021 | 00:37h | UTC

Concussion in para sport: the first position statement of the Concussion in Para Sport (CIPS) Group – British Journal of Sports Medicine

 

Commentary on Twitter

 


RCT: Effect of High-frequency (10-kHz) Spinal Cord Stimulation in Patients With Painful Diabetic Neuropathy

9 Apr, 2021 | 03:18h | UTC

Effect of High-frequency (10-kHz) Spinal Cord Stimulation in Patients With Painful Diabetic Neuropathy: A Randomized Clinical Trial – JAMA Neurology

Author Interview: Effect of High-Frequency (10 kHz) Spinal Cord Stimulation in Patients With Painful Diabetic Neuropathy

 

Commentary on Twitter

 


NICE Guideline: Assessment and Management of Chronic Pain in Over 16s

8 Apr, 2021 | 08:54h | UTC

Chronic pain (primary and secondary) in over 16s: assessment of all chronic pain and management of chronic primary pain – National Institute for Health and Care Excellence

News release: NICE recommends range of effective treatments for people with chronic primary pain and calls on healthcare professionals to recognise and treat a person’s pain as valid and unique to them

 


Large study finds 1 in 3 Covid-19 survivors have subsequent mental health and neurological conditions

8 Apr, 2021 | 09:14h | UTC

6-month neurological and psychiatric outcomes in 236 379 survivors of COVID-19: a retrospective cohort study using electronic health records – The Lancet Psychiatry

Commentaries: 1 in 3 Covid-19 patients are diagnosed with a neuropsychiatric condition in the next six months, large study finds – STAT AND A longer look at COVID-19 and neuropsychiatric outcomes – The Lancet Psychiatry AND Largest study to date suggests link between COVID-19 infection and subsequent mental health and neurological conditions – The Lancet AND Covid-19: One in three has neurological or psychiatric condition diagnosed after covid infection, study finds – The BMJ AND One in three survivors of severe Covid diagnosed with mental health condition – The Guardian AND Covid-19 linked to depression and dementia, study suggests – BBC AND Expert reaction to observational study looking at neurological and psychiatric outcomes 6 months after COVID-19 – Science Media Centre AND 1 in 3 COVID Survivors Struggle With Mental Health Issues Months Later – HealthDay

 

Commentary on Twitter (thread – click for more)

 


Cohort study: One in ten have long-term effects 8 months following mild COVID-19

8 Apr, 2021 | 09:12h | UTC

One in ten have long-term effects 8 months following mild COVID-19 – Karolinska Institutet

Original study: Symptoms and Functional Impairment Assessed 8 Months After Mild COVID-19 Among Health Care Workers – JAMA

 

Commentary on Twitter

 


Cohort study: Risk of suicide attempt in patients with recent diagnosis of mild cognitive impairment or dementia

7 Apr, 2021 | 01:08h | UTC

Risk of Suicide Attempt in Patients With Recent Diagnosis of Mild Cognitive Impairment or Dementia – JAMA Psychiatry (link to abstract – $ for full-text)

Commentaries: Recent Diagnosis of Cognitive Impairment, Dementia May Increase Suicide Risk – Psychiatric News Alert AND Suicide Attempts Spike Soon After Dementia Diagnosis – HealthDay

 


Exceedingly rare side effects reported with AstraZeneca vaccine in the UK – 22 cases of cerebral venous sinus thrombosis with low levels of platelets out of 18 million vaccinated individuals

5 Apr, 2021 | 01:45h | UTC

Covid-19: Seven UK blood clot deaths after AstraZeneca vaccine – BBC

Original report: Coronavirus vaccine – weekly summary of Yellow Card reporting – Medicines and Healthcare products Regulatory Agency

Related opinion: Undermining the AstraZeneca jab is a dangerous act of political folly – The Guardian

“Based on current experience, the expected benefits of both COVID-19 vaccines in preventing COVID-19 and its serious complications far outweigh any known side effects”

 


M-A: Non-drug therapies as good as or better than drugs for treating depression in people with dementia

2 Apr, 2021 | 09:05h | UTC

Comparative efficacy of interventions for reducing symptoms of depression in people with dementia: systematic review and network meta-analysis – The BMJ

Commentaries: Non-drug therapies as good as or better than drugs for treating depression in people with dementia – The BMJ AND Social prescribing may help reduce symptoms of depression in people with dementia – The BMJ Opinion AND Nondrug Interventions Can Help Alleviate Depression in Dementia Patients – HealthDay

 


Long Covid in the UK – More than a million affected in February, survey suggests

2 Apr, 2021 | 09:31h | UTC

Long Covid: More than a million affected in February, survey suggests – BBC

Report: Prevalence of ongoing symptoms following coronavirus (COVID-19) infection in the UK: 1 April 2021 – Office for National Statistics

 

Commentary on Twitter

 


Study shows unique diagnostic signatures of concussion in the saliva of Rugby players

31 Mar, 2021 | 03:08h | UTC

Unique diagnostic signatures of concussion in the saliva of male athletes: the Study of Concussion in Rugby Union through MicroRNAs (SCRUM) – British Journal of Sports Medicine

Commentaries: Concussion in sport: Saliva test is 94% accurate in rugby union trial – BBC AND Rugby study identifies new method to diagnose concussion using saliva – University of Birmingham AND Saliva test boosts efforts to detect concussions in rugby – Associated Press

 


COVID associated with hearing loss, tinnitus and vertigo – new study confirms link

30 Mar, 2021 | 03:19h | UTC

COVID associated with hearing loss, tinnitus and vertigo – new study confirms link – The Conversation

Original study: One year on: an updated systematic review of SARS-CoV-2, COVID-19 and audio-vestibular symptoms – International Journal of Audiology

 


NICE Guideline Update: Cannabis-based medicinal products

28 Mar, 2021 | 22:24h | UTC

Cannabis-based medicinal products – National Institute for Health and Care Excellence

 


Long term outcomes of participants in the PARAMEDIC2 randomized trial of adrenaline in out-of-hospital cardiac arrest – although survival was improved, adrenalin was not associated with favorable neurologic outcomes

28 Mar, 2021 | 22:21h | UTC

Long term outcomes of participants in the PARAMEDIC2 randomised trial of adrenaline in out-of-hospital cardiac arrest – Resuscitation

Commentary: PARAMEDIC2 – Epinephrine vs Placebo OHCA 6-12 Months – Journal Feed

Original study: Randomized Trial: Epinephrine in Out-of-Hospital Cardiac Arrest (study and commentaries) AND Opinion: Epinephrine Harms/Helps in Out of Hospital Cardiac Arrest

 


Choosing Wisely: Five things clinicians and patients should question in Neurological Surgery in Children

28 Mar, 2021 | 22:04h | UTC

American Academy of Pediatrics – Section on Neurological Surgery – Choosing Wisely

Commentary: Choosing Wisely: 5 Things to Avoid in Pediatric Neurologic Surgery – NEJM Journal Watch

See complete lists of low-value practices: Choosing Wisely U.S. / Choosing Wisely UK / Choosing Wisely Australia AND Choosing Wisely Canada

 


How COVID-19 Affects the Brain

28 Mar, 2021 | 22:51h | UTC

How COVID-19 Affects the Brain – JAMA Psychiatry

 

Commentary on Twitter

 


Covid-19: Middle aged women face greater risk of debilitating long term symptoms

28 Mar, 2021 | 22:49h | UTC

Covid-19: Middle aged women face greater risk of debilitating long term symptoms – The BMJ

Linked Opinion: The stigma is real for people living with long covid – The BMJ Opinion

 


Persistent neurologic symptoms and cognitive dysfunction in non‐hospitalized Covid‐19 “long haulers”

28 Mar, 2021 | 22:48h | UTC

Persistent neurologic symptoms and cognitive dysfunction in non‐hospitalized Covid‐19 “long haulers” – Annals of Clinical and Translational Neurology

Commentary: 85% of COVID-19 long-haulers have multiple brain-related symptoms – LiveScience AND ‘Brain fog’ and other neurologic symptoms can last for months after Covid – NBC News AND Neurologic Symptoms Persistent for Many COVID-19 ‘Long-Haulers’ – Health Day

 


RCT: Metoclopramide + diphenhydramine more efficacious than placebo for acute post-traumatic headache in the ED

26 Mar, 2021 | 08:24h | UTC

Randomized Study of Metoclopramide Plus Diphenhydramine for Acute Posttraumatic Headache – Neurology (link to abstract – $ for full-text)

Commentary: Drug Combo Superior to Placebo for Posttraumatic Headache – HealthDay

 


RCT: Surgical microdiscectomy versus transforaminal epidural steroid injection in patients with sciatica secondary to herniated lumbar disc

25 Mar, 2021 | 08:12h | UTC

Surgical microdiscectomy versus transforaminal epidural steroid injection in patients with sciatica secondary to herniated lumbar disc (NERVES): a phase 3, multicentre, open-label, randomised controlled trial and economic evaluation – The Lancet Rheumatology

 

Commentary on Twitter

 


RCT: Aspirin NOT noninferior to vitamin K antagonists in the treatment of cervical artery dissection

24 Mar, 2021 | 08:09h | UTC

Aspirin versus anticoagulation in cervical artery dissection (TREAT-CAD): an open-label, randomised, non-inferiority trial – The Lancet Neurology (link to abstract – $ for full-text)

 


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