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Neurology

Randomized trial: Endovascular treatment alone noninferior to intravenous alteplase plus endovascular treatment on functional independence in patients with acute ischemic stroke

20 Jan, 2021 | 01:35h | UTC

Effect of Endovascular Treatment Alone vs Intravenous Alteplase Plus Endovascular Treatment on Functional Independence in Patients With Acute Ischemic Stroke: The DEVT Randomized Clinical Trial – JAMA (free for a limited period)

Related study: Effect of Mechanical Thrombectomy Without vs With Intravenous Thrombolysis on Functional Outcome Among Patients With Acute Ischemic Stroke: The SKIP Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Intravenous Thrombolysis Before Endovascular Thrombectomy for Acute Ischemic Stroke – JAMA (free for a limited period)

Video: Thrombolysis Before Thrombectomy for Stroke

 


Randomized Trial of Focused Ultrasound Subthalamotomy for Parkinson’s Disease

20 Jan, 2021 | 01:20h | UTC

Randomized Trial of Focused Ultrasound Subthalamotomy for Parkinson’s Disease – New England Journal of Medicine

Commentary: Parkinson’s Motor Symptoms Improve with Focused Ultrasound — Adverse events were frequent, with some persisting 4 months or longer

 


Study: Seizure frequency does not increase during Pregnancy

15 Jan, 2021 | 08:28h | UTC

Changes in Seizure Frequency and Antiepileptic Therapy during Pregnancy – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: MONEAD Study: Does Pregnancy Lead to Increased Seizure Frequency in Women with Epilepsy? – Physician’s Weekly AND Pregnancy Does Not Increase Seizures in Women With Epilepsy – Medscape

 


AASM Guideline: Behavioral and psychological treatments for chronic insomnia disorder in adults

13 Jan, 2021 | 01:58h | UTC

Behavioral and psychological treatments for chronic insomnia disorder in adults: an American Academy of Sleep Medicine clinical practice guideline – Journal of Clinical Sleep Medicine

Commentary: New guideline encourages use of cognitive behavioral therapy for insomnia in adults – ACP Internist

 


Systematic review: Acute treatments for episodic migraine

13 Jan, 2021 | 01:56h | UTC

Acute Treatments for Episodic Migraine – Agency for Healthcare Research and Quality

Full text: Acute Treatments for Episodic Migraine

Evidence summary: Acute Treatments for Episodic Migraine

 


Systematic review: There is no evidence that Souvenaid is useful for preventing dementia or provide benefit for patients with Alzheimer’s disease

13 Jan, 2021 | 01:47h | UTC

Souvenaid for Alzheimer’s disease – Cochrane Library

 


Cohort study: Prevalence and risk factors for delirium in critically ill patients with COVID-19

12 Jan, 2021 | 01:55h | UTC

Prevalence and risk factors for delirium in critically ill patients with COVID-19 (COVID-D): a multicentre cohort study – The Lancet Respiratory Medicine

Commentaries: Sedation in mechanically ventilated patients with COVID-19 – The Lancet Respiratory Medicine AND Large study finds higher burden of acute brain dysfunction for COVID-19 ICU patients – Vanderbilt University Medical Center

 


Randomized trial: Ultra-early tranexamic acid does not improve outcomes after subarachnoid hemorrhage

10 Jan, 2021 | 21:02h | UTC

Ultra-early tranexamic acid after subarachnoid haemorrhage (ULTRA): a randomised controlled trial – The Lancet (link to abstract – $ for full-text)

 

 


Guideline Synopsis: Management of patients with a patent foramen ovale with history of stroke or TIA

10 Jan, 2021 | 20:19h | UTC

Management of Patients With a Patent Foramen Ovale With History of Stroke or TIA – JAMA (free for a limited period)

Original Guideline: Practice advisory update summary: Patent foramen ovale and secondary stroke prevention: Report of the Guideline Subcommittee of the American Academy of Neurology – Neurology

 


Meta-analysis: Effectiveness of bundle interventions on ICU delirium

10 Jan, 2021 | 20:16h | UTC

Effectiveness of Bundle Interventions on ICU Delirium: A Meta-Analysis – Critical Care Medicine

Commentary: ICU bundles do not appear to improve delirium but may help other outcomes – ACP Hospitalist

 

Commentary on Twitter

 


Neuroimaging manifestations in children with SARS-CoV-2 infection: a multinational, multicenter collaborative study

18 Dec, 2020 | 09:50h | UTC

Neuroimaging manifestations in children with SARS-CoV-2 infection: a multinational, multicentre collaborative study – The Lancet Child & Adolescent Health

Commentary: Study highlights neurological impact of COVID-19 on children – University of Manchester

 

Commentary on Twitter (thread – click for more)

 


Randomized trial: Dexamethasone for chronic subdural hematoma resulted in fewer favorable outcomes and more adverse events than placebo at 6 months

17 Dec, 2020 | 09:02h | UTC

Trial of Dexamethasone for Chronic Subdural Hematoma – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Dexamethasone should be avoided in patients with chronic subdural haematoma – University of Cambridge AND Dexamethasone for Chronic Subdural Hematoma? – NEJM Journal Watch

 

Commentary on Twitter

 


“Neurological manifestations of COVID-19” – guideline of the German society of neurology

9 Dec, 2020 | 08:15h | UTC

“Neurological manifestations of COVID-19” – guideline of the German society of neurology – Neurological Research and Practice

 


Could COVID delirium bring on dementia?

4 Dec, 2020 | 08:11h | UTC

Could COVID delirium bring on dementia? – Nature

 


Cohort study: Higher dose Z-drug use in dementia is associated with increased fracture and stroke risks, similar or greater to that for higher dose benzodiazepines

1 Dec, 2020 | 08:25h | UTC

Adverse effects of Z-drugs for sleep disturbance in people living with dementia: a population-based cohort study – BMC Medicine

Commentary: The danger of Z-drugs for dementia patients – University of Exeter

 


Randomized trial: Prednisone is an effective short-term preventive therapy in patients with episodic cluster headache

25 Nov, 2020 | 09:01h | UTC

Safety and efficacy of prednisone versus placebo in short-term prevention of episodic cluster headache: a multicentre, double-blind, randomised controlled trial – The Lancet Neurology (link to abstract – $ for full-text)

 

Commentary from the author on Twitter

 


Opinion – Football and dementia: heading must be banned until the age of 18

24 Nov, 2020 | 09:24h | UTC

Football and dementia: heading must be banned until the age of 18 – The Conversation

 


Randomized, placebo-controlled, crossover trial: Amantadine, modafinil, and methylphenidate are no better than placebo for fatigue in multiple sclerosis

24 Nov, 2020 | 09:02h | UTC

Safety and efficacy of amantadine, modafinil, and methylphenidate for fatigue in multiple sclerosis: a randomised, placebo-controlled, crossover, double-blind trial – The Lancet Neurology (link to abstract – $ for full-text)

 


Older adults with COVID-19 commonly present to the ED with delirium

20 Nov, 2020 | 08:46h | UTC

Delirium in Older Patients With COVID-19 Presenting to the Emergency Department – JAMA Network Open

Commentaries: Delirium could signal Covid-19 infection in older adults, study finds – STAT AND Delirium fairly common in older COVID-19 patients – CIDRAP AND Delirium is first symptom for many elderly COVID-19 patients – UPI

 

Commentary on Twitter

 


Systematic review: Management of primary headaches in pregnancy

18 Nov, 2020 | 09:00h | UTC

Management of Primary Headaches in Pregnancy – Agency for Healthcare Research and Quality

Full report: Management of Primary Headaches in Pregnancy

Evidence Summary: Management of Primary Headaches in Pregnancy

 


Sleep problems in dementia: Despite many drugs being widely prescribed, systematic review finds lack of evidence and no randomized controlled trials to guide decisions about drug treatment

17 Nov, 2020 | 09:29h | UTC

Pharmacotherapies for sleep disturbances in dementia – Cochrane Library

 


Case-control study: COVID-19-associated stroke is associated with worse outcomes and increased mortality

12 Nov, 2020 | 09:24h | UTC

Characteristics and outcomes of COVID-19-associated stroke: a UK multicentre case-control study – Journal of Neurology, Neurosurgery & Psychiatry

Commentary: Risk of death, disability after stroke much higher for COVID-19 patients – Cardiovascular Business

 


Meta-analysis: Intravenous alteplase for stroke with unknown time of onset guided by advanced imaging can reduce cases of severe disability but increases symptomatic intracranial hemorrhage and deaths

11 Nov, 2020 | 09:06h | UTC

Intravenous alteplase for stroke with unknown time of onset guided by advanced imaging: systematic review and meta-analysis of individual patient data – The Lancet (free registration required)

 

Commentary on Twitter

 


Another study shows improved outcomes with dual antiplatelet therapy in the first weeks after an acute ischemic stroke or transient ischemic attack

9 Nov, 2020 | 01:16h | UTC

Ticagrelor Added to Aspirin in Acute Ischemic Stroke or Transient Ischemic Attack in Prevention of Disabling Stroke: A Randomized Clinical Trial – JAMA Neurology

Related Guideline: Dual antiplatelet therapy with aspirin and clopidogrel for acute high risk transient ischaemic attack and minor ischaemic stroke – The BMJ

 


International consensus guidance for management of myasthenia gravis: The 2020 version includes updated recommendations for thymectomy, for early immunosuppression in ocular MG, and for the management of MG associated with immune checkpoint inhibitor treatment

6 Nov, 2020 | 09:46h | UTC

International consensus guidance for management of myasthenia gravis: 2020 update – Neurology

 


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