Neurology | Links Medicus Free Medical News & Perspectives

Tranexamic acid treatment in spontaneous subarachnoid haemorrhage, started immediately after CT diagnosis and continued until start of the aneurysm treatment as early as possible, does not improve clinical outcome, finds new randomised controlled trial: https://t.co/R0AhtszaY5 pic.twitter.com/Bnft9XgBA9

— The Lancet (@TheLancet) December 22, 2020

Guideline Synopsis: Management of patients with a patent foramen ovale with history of stroke or TIA

10 Jan, 2021 | 20:19h | UTC

Management of Patients With a Patent Foramen Ovale With History of Stroke or TIA – JAMA (free for a limited period)

Original Guideline: Practice advisory update summary: Patent foramen ovale and secondary stroke prevention: Report of the Guideline Subcommittee of the American Academy of Neurology – Neurology

Meta-analysis: Effectiveness of bundle interventions on ICU delirium

10 Jan, 2021 | 20:16h | UTC

Effectiveness of Bundle Interventions on ICU Delirium: A Meta-Analysis – Critical Care Medicine

Commentary: ICU bundles do not appear to improve delirium but may help other outcomes – ACP Hospitalist

Commentary on Twitter

Meta-Analysis incl 11 studies and 26,384 patients for bundle-interventions of delirium treatment showed no effects on delirum duration ( –1.42 d; 95% CI –3.06 to 0.22) or prevalence (risk ratio = 0.92; 95% CI, 0.68–1.24)https://t.co/PzZBGttOL8

— Peter Nydahl (@NydahlPeter) December 18, 2020

Neuroimaging manifestations in children with SARS-CoV-2 infection: a multinational, multicenter collaborative study

18 Dec, 2020 | 09:50h | UTC

Neuroimaging manifestations in children with SARS-CoV-2 infection: a multinational, multicentre collaborative study – The Lancet Child & Adolescent Health

Commentary: Study highlights neurological impact of COVID-19 on children – University of Manchester

Commentary on Twitter (thread – click for more)

New #COVID19 Research: An international call for cases identified 38 children with neurological disease related to #SARSCoV2 infection

Recurring patterns of disease were identified, with #neuroimaging abnormalities ranging from mild to severehttps://t.co/a3bjPlOY0z pic.twitter.com/W0lxLP4aAh

— The Lancet Child & Adolescent Health (@LancetChildAdol) December 16, 2020

Randomized trial: Dexamethasone for chronic subdural hematoma resulted in fewer favorable outcomes and more adverse events than placebo at 6 months

17 Dec, 2020 | 09:02h | UTC

Trial of Dexamethasone for Chronic Subdural Hematoma – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Dexamethasone should be avoided in patients with chronic subdural haematoma – University of Cambridge AND Dexamethasone for Chronic Subdural Hematoma? – NEJM Journal Watch

Commentary on Twitter

In a trial that compared a 2-week course of dexamethasone with placebo in patients with a chronic subdural hematoma, a favorable outcome on the modified Rankin scale at 6 months was more common in the placebo group than in the dexamethasone group.

— NEJM (@NEJM) December 17, 2020

“Neurological manifestations of COVID-19” – guideline of the German society of neurology

9 Dec, 2020 | 08:15h | UTC

“Neurological manifestations of COVID-19” – guideline of the German society of neurology – Neurological Research and Practice

Could COVID delirium bring on dementia?

4 Dec, 2020 | 08:11h | UTC

Could COVID delirium bring on dementia? – Nature

Cohort study: Higher dose Z-drug use in dementia is associated with increased fracture and stroke risks, similar or greater to that for higher dose benzodiazepines

1 Dec, 2020 | 08:25h | UTC

Adverse effects of Z-drugs for sleep disturbance in people living with dementia: a population-based cohort study – BMC Medicine

Commentary: The danger of Z-drugs for dementia patients – University of Exeter

Randomized trial: Prednisone is an effective short-term preventive therapy in patients with episodic cluster headache

25 Nov, 2020 | 09:01h | UTC

Safety and efficacy of prednisone versus placebo in short-term prevention of episodic cluster headache: a multicentre, double-blind, randomised controlled trial – The Lancet Neurology (link to abstract – $ for full-text)

Commentary from the author on Twitter

Finally published online! After countless years and a lot of work our study on prednisone for the treatment of episodic cluster headache. Thanks to all the many people that were involved in this study, Very proud!!! #PredCH #Clusterheadache https://t.co/d88TUWTY5i

— Mark Obermann (@moeb07) November 25, 2020

Opinion – Football and dementia: heading must be banned until the age of 18

24 Nov, 2020 | 09:24h | UTC

Football and dementia: heading must be banned until the age of 18 – The Conversation

Randomized, placebo-controlled, crossover trial: Amantadine, modafinil, and methylphenidate are no better than placebo for fatigue in multiple sclerosis

24 Nov, 2020 | 09:02h | UTC

Safety and efficacy of amantadine, modafinil, and methylphenidate for fatigue in multiple sclerosis: a randomised, placebo-controlled, crossover, double-blind trial – The Lancet Neurology (link to abstract – $ for full-text)

Older adults with COVID-19 commonly present to the ED with delirium

20 Nov, 2020 | 08:46h | UTC

Delirium in Older Patients With COVID-19 Presenting to the Emergency Department – JAMA Network Open

Commentaries: Delirium could signal Covid-19 infection in older adults, study finds – STAT AND Delirium fairly common in older COVID-19 patients – CIDRAP AND Delirium is first symptom for many elderly COVID-19 patients – UPI

Commentary on Twitter

In older ED patients w/ COVID-19 only 56% had a fever, 51% SOB & 50% cough. 28% had delirium & one third of delirious pts lacked typical symptoms. In the ED delirium may the only symptom of #COVID19. @sharon_inouye @ACEPNow @GeriatricEDNews @AGEM_SAEM @JAMANetworkOpen pic.twitter.com/MxjSTx3Ffi

— Maura Kennedy (@MauraKennedyMD) November 19, 2020

Systematic review: Management of primary headaches in pregnancy

18 Nov, 2020 | 09:00h | UTC

Management of Primary Headaches in Pregnancy – Agency for Healthcare Research and Quality

Full report: Management of Primary Headaches in Pregnancy

Evidence Summary: Management of Primary Headaches in Pregnancy

Sleep problems in dementia: Despite many drugs being widely prescribed, systematic review finds lack of evidence and no randomized controlled trials to guide decisions about drug treatment

17 Nov, 2020 | 09:29h | UTC

Pharmacotherapies for sleep disturbances in dementia – Cochrane Library

Case-control study: COVID-19-associated stroke is associated with worse outcomes and increased mortality

12 Nov, 2020 | 09:24h | UTC

Characteristics and outcomes of COVID-19-associated stroke: a UK multicentre case-control study – Journal of Neurology, Neurosurgery & Psychiatry

Commentary: Risk of death, disability after stroke much higher for COVID-19 patients – Cardiovascular Business

Meta-analysis: Intravenous alteplase for stroke with unknown time of onset guided by advanced imaging can reduce cases of severe disability but increases symptomatic intracranial hemorrhage and deaths

11 Nov, 2020 | 09:06h | UTC

Intravenous alteplase for stroke with unknown time of onset guided by advanced imaging: systematic review and meta-analysis of individual patient data – The Lancet (free registration required)

Commentary on Twitter

Latebreaking at #ESOWSO2020—Intravenous alteplase for #stroke with unknown time of onset guided by advanced imaging: systematic review and meta-analysis of individual patient data https://t.co/KDX2lHisbj pic.twitter.com/cnoiRhIReF

— The Lancet (@TheLancet) November 8, 2020