Neurology
RCT | Donanemab slows early symptomatic Alzheimer’s progression, but raises serious safety concerns
18 Jul, 2023 | 13:51h | UTCDonanemab in Early Symptomatic Alzheimer Disease: The TRAILBLAZER-ALZ 2 Randomized Clinical Trial – JAMA (free for a limited period)
Editorials:
Donanemab for Alzheimer Disease—Who Benefits and Who Is Harmed? – JAMA (free for a limited period)
Amyloid-Targeting Monoclonal Antibodies for Alzheimer Disease – JAMA (free for a limited period)
Ushering in a New Era of Alzheimer Disease Therapy – JAMA (free for a limited period)
See also: Visual Abstract
Commentary: Expert reaction to results from Eli Lilly on its anti-amyloid drug donanemab – Science Media Centre
Related: RCT | Lecanemab slows cognitive decline in early Alzheimer’s disease but raises safety concerns.
Nationwide Cohort Study | Adolescent hypertension linked with increased stroke risk in young adulthood
18 Jul, 2023 | 13:49h | UTCCommentary: The Relationship Between Adolescent Hypertension and Stroke Risk After Age 40 Years – Neurology Advisor
Meta-Analysis | Nearly 6% of first-episode psychosis patients exhibit clinically relevant MRI abnormalities
17 Jul, 2023 | 13:32h | UTCNews Release: Routine brain scanning may improve clinical care for people with psychosis – University of Oxford
Brief Review | Neurological diseases in intensive care
17 Jul, 2023 | 13:19h | UTCNeurological diseases in intensive care – Intensive Care Medicine
Commentary on Twitter
Neurological diseases in #ICU
◼️ black box of neurocritical care
? heterogeneity of care
⏳ impact of early interventions on long‑term outcomes
? side effects of medical treatments/unexpected trial results
? neuro-prognostication#FOAMcc @yourICM
?️ https://t.co/w3GUhQGGGs pic.twitter.com/fzkRghKHB2— Intensive Care Medicine (@yourICM) July 12, 2023
Clinical practice guideline for deprescribing opioid analgesics
12 Jul, 2023 | 13:58h | UTCRelated:
RCT | Opioids not more effective than placebo for acute low back and neck pain
RCT | A deprescribing intervention reduced medication burden among older adults in post-acute care
Deprescribing proton pump inhibitors – Australian Journal of General Practice
Antihypertensive Deprescribing in Older Adults: a Practical Guide – Current Hypertension Reports
Deprescribing in Palliative Cancer Care – Life
Less is More: Deprescribing Medications in Older Adults with Kidney Disease: A Review – Kidney360
Polypharmacy Management in Older Patients – Mayo Clinic Proceedings
Eliminating Medication Overload: A National Action Plan – Lown Institute
Common ED Medication Errors: Polypharmacy – emDocs
Current and future perspectives on the management of polypharmacy – BMC Family Practice
Polypharmacy—an Upward Trend with Unpredictable Effects – Deutsches Ärzteblatt international
Clinical Consequences of Polypharmacy in Elderly – Expert Opinion on Drug Safety
M-A | The effect of blood pressure lowering medications on the prevention of episodic migraine
12 Jul, 2023 | 13:50h | UTCNews Release: New study shows common blood pressure meds underused for migraine – George Institute for Global Health
M-A | Cognitive rehabilitation may improve everyday activities in mild to moderate dementia
12 Jul, 2023 | 13:34h | UTCCognitive rehabilitation for people with mild to moderate dementia – Cochrane Library
Cohort Study | Long-term use of menopausal hormone therapy linked to heightened dementia risk
11 Jul, 2023 | 14:04h | UTCMenopausal hormone therapy and dementia: nationwide, nested case-control study – The BMJ
Editorial: Menopausal hormone therapy and dementia – The BMJ
News Release: Menopausal hormone therapy linked to increased rate of dementia – BMJ Newsroom
Commentaries: Expert reaction to observational study on HRT and dementia – Science Media Centre
Subarachnoid hemorrhage | ED presentation, evaluation, and management
11 Jul, 2023 | 13:49h | UTCSubarachnoid hemorrhage: ED presentation, evaluation, and management – emDocs
Related:
AHA/ASA Guideline for the management of patients with aneurysmal subarachnoid hemorrhage
RCT | Butylphthalide may enhance functional outcomes in acute ischemic stroke patients undergoing reperfusion therapy
11 Jul, 2023 | 13:46h | UTCEfficacy and Safety of Butylphthalide in Patients With Acute Ischemic Stroke: A Randomized Clinical Trial – JAMA Neurology (link to abstract – $ for full-text)
See also: Visual Abstract
RCT | Dual antiplatelet therapy proves noninferior to alteplase in minor ischemic stroke
10 Jul, 2023 | 13:58h | UTCDual Antiplatelet Therapy vs Alteplase for Patients With Minor Nondisabling Acute Ischemic Stroke: The ARAMIS Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)
See also: Visual Abstract
Review | Evaluation of acute adult disorders of consciousness for the general intensivist
10 Jul, 2023 | 13:37h | UTCState-of-the-Art Evaluation of Acute Adult Disorders of Consciousness for the General Intensivist – Critical Care Medicine (free for a limited period)
Cohort Study | Hypertensive disorders of pregnancy linked to a 66% higher stroke risk in U.S. black women
10 Jul, 2023 | 13:31h | UTCHypertensive Disorders of Pregnancy and Risk of Stroke in U.S. Black Women – NEJM Medicine
RCT | Semont-plus maneuver yields faster recovery than Epley maneuver in posterior canal BPPV
7 Jul, 2023 | 16:26h | UTCThe Semont-Plus Maneuver or the Epley Maneuver in Posterior Canal Benign Paroxysmal Positional Vertigo: A Randomized Clinical Study – JAMA Neurology (link to abstract – $ for full-text)
See also: Visual Abstract
Videos:
Demonstration of the Semont-Plus Self-maneuver for Right Posterior Canal Canalithiasis
Semont-Plus Maneuver for Right Posterior Canal Benign Paroxysmal Positional Vertigo
Demonstration of the Epley Self-maneuver for a Right Posterior Canal Canalithiasis
Commentary: Semont-plus Meneuver Offered Faster Recovery for Benign Paroxysmal Positional Vertigo – Neurology Today
Review | Respiratory challenges and ventilatory management in different types of acute brain-injured patients
3 Jul, 2023 | 14:17h | UTC
M-A | Metoclopramide effective in acute migraine relief, comparable to most active drugs, superior to placebo
30 Jun, 2023 | 14:51h | UTC
M-A | Tracheostomy timing not a key determinant of clinical outcomes in critically ill stroke patients
30 Jun, 2023 | 14:50h | UTC
Development and validation of an international preoperative risk assessment model for postoperative delirium
30 Jun, 2023 | 14:43h | UTC
Review | Silent cerebral lesions following catheter ablation for atrial fibrillation
29 Jun, 2023 | 13:51h | UTC
Commentary on Twitter
What's the risk of silent cerebral lesions following catheter ablation for #AF?? https://t.co/GJsUziHLeu@EuropaceEiC @GiulioConte9 @AAuricchioMD @Dominik_Linz @FraSantoroMD @AndyZhangMD @marcovitoloMD @DhirajGuptaBHRS #AF #ablation #europace pic.twitter.com/ZYQP7oS9sS
— European Society of Cardiology Journals (@ESC_Journals) June 21, 2023
Choosing Wisely | Recommendations for advance care planning
22 Jun, 2023 | 15:18h | UTCSee complete lists of low-value practices: Choosing Wisely U.S. / Choosing Wisely UK / Choosing Wisely Australia AND Choosing Wisely Canada
Review | Intracranial pressure monitoring and management in aneurysmal subarachnoid hemorrhage
22 Jun, 2023 | 15:02h | UTC
M-A | No significant difference between thrombo-aspiration and stent-retrieval thrombectomy in ischemic stroke treatment
22 Jun, 2023 | 15:00h | UTCSummary: Different types of percutaneous endovascular treatments for acute ischemic stroke – Cochrane Library
RCT | Use of lumbar drains improves 6-month outcomes in patients with aneurysmal subarachnoid hemorrhage
20 Jun, 2023 | 12:55h | UTCSee also: Visual Abstract
Commentary on Twitter
In this trial, among patients with aneurysmal subarachnoid hemorrhage, lumbar drainage improved clinical neurological outcomes at 6 months. https://t.co/SZjuQoGoku pic.twitter.com/szKcZaPL9K
— JAMA Neurology (@JAMANeuro) June 18, 2023
RCT | In chronic subdural hematoma, dexamethasone fails to match surgery for functional outcomes
20 Jun, 2023 | 12:53h | UTCDexamethasone versus Surgery for Chronic Subdural Hematoma – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Dexamethasone Compared to Burr-Hole Drainage for Chronic Subdural Hematoma – HealthDay
Guidelines for the management of trigeminal neuralgia
20 Jun, 2023 | 12:43h | UTCGuidelines for the management of trigeminal neuralgia – Cleveland Clinic Journal of Medicine