Open access
Open access
Powered by Google Translator Translator

Neurology

RCT | Donanemab slows early symptomatic Alzheimer’s progression, but raises serious safety concerns

18 Jul, 2023 | 13:51h | UTC

Donanemab in Early Symptomatic Alzheimer Disease: The TRAILBLAZER-ALZ 2 Randomized Clinical Trial – JAMA (free for a limited period)

Editorials:

Donanemab for Alzheimer Disease—Who Benefits and Who Is Harmed? – JAMA (free for a limited period)

Amyloid-Targeting Monoclonal Antibodies for Alzheimer Disease – JAMA (free for a limited period)

Ushering in a New Era of Alzheimer Disease Therapy – JAMA (free for a limited period)

See also: Visual Abstract

Commentary: Expert reaction to results from Eli Lilly on its anti-amyloid drug donanemab – Science Media Centre

Related: RCT | Lecanemab slows cognitive decline in early Alzheimer’s disease but raises safety concerns.

 


Nationwide Cohort Study | Adolescent hypertension linked with increased stroke risk in young adulthood

18 Jul, 2023 | 13:49h | UTC

Adolescent Hypertension Is Associated With Stroke in Young Adulthood: A Nationwide Cohort of 1.9 Million Adolescents – Stroke

Commentary: The Relationship Between Adolescent Hypertension and Stroke Risk After Age 40 Years – Neurology Advisor

 


Meta-Analysis | Nearly 6% of first-episode psychosis patients exhibit clinically relevant MRI abnormalities

17 Jul, 2023 | 13:32h | UTC

Prevalence of Neuroradiological Abnormalities in First-Episode Psychosis: A Systematic Review and Meta-analysis – JAMA Psychiatry

News Release: Routine brain scanning may improve clinical care for people with psychosis – University of Oxford

 


Brief Review | Neurological diseases in intensive care

17 Jul, 2023 | 13:19h | UTC

Neurological diseases in intensive care – Intensive Care Medicine

 

Commentary on Twitter

 


Clinical practice guideline for deprescribing opioid analgesics

12 Jul, 2023 | 13:58h | UTC

Clinical practice guideline for deprescribing opioid analgesics: summary of recommendations – Medical Journal of Australia

Related:

RCT | Opioids not more effective than placebo for acute low back and neck pain

Deprescribing considerations for older people in general practice – Australian Journal of General Practice

Deprescribing Strategies for Opioids and Benzodiazepines with Emphasis on Concurrent Use: A Scoping Review – Journal of Clinical Medicine

An Overview of Systematic Reviews and Meta-Analyses on the Effect of Medication Interventions Targeting Polypharmacy for Frail Older Adults – Journal of Clinical Medicine

Physician-led medication reviews in polypharmacy patients treated with at least 12 medications in a type 2 diabetes outpatient clinic: a randomised trial – Diabetic Medicine

RCT | A deprescribing intervention reduced medication burden among older adults in post-acute care

Achieving sustainable healthcare through deprescribing of unnecessary medications: making sense of the evidence – Cochrane Library

Deprescribing medicines in older people living with multimorbidity and polypharmacy: the TAILOR evidence synthesis – Health Technology Assessment

Barriers and facilitators to deprescribing of cardiovascular medications: a systematic review – BMJ Open

A National Modified Delphi Consensus Process to Prioritize Experiences and Interventions for Antipsychotic Medication Deprescribing Among Adult Patients With Critical Illness – Critical Care Explorations

Deprescribing proton pump inhibitors – Australian Journal of General Practice

Medication reviews and deprescribing as a single intervention in falls prevention: a systematic review and meta-analysis – Age and Ageing

Optimizing Medication Use in Older Adults With Rheumatic Musculoskeletal Diseases: Deprescribing as an Approach When Less May Be More – ACP Open Rheumatology

Facing the challenge of polypharmacy when prescribing for older people with cardiovascular disease. A review by the European Society of Cardiology Working Group on Cardiovascular Pharmacotherapy – European Heart Journal – Cardiovascular Pharmacotherapy

Deprescribing in Older Adults with Cardiovascular Disease – Journal of the American College of Cardiology

Multimorbidity in Older Adults with Cardiovascular Disease – American College of Cardiology, Latest in Cardiology

Antihypertensive Deprescribing in Older Adults: a Practical Guide – Current Hypertension Reports

How-to guide for medication reviews in older adults with cancer: A Young International Society of Geriatric Oncology and Nursing & Allied Health Interest Group initiative – Journal of Geriatric Oncology

Deprescribing in Palliative Cancer Care – Life

Less is More: Deprescribing Medications in Older Adults with Kidney Disease: A Review – Kidney360

Process evaluation of implementation strategies to reduce potentially inappropriate medication prescribing in older population: A scoping review – Research in Social and Administrative Pharmacy

AGA Clinical Practice Update on De-Prescribing of Proton Pump Inhibitors: Expert Review – Gastroenterology

Development of a Metric to Detect and Decrease Low-Value Prescribing in Older Adults – JAMA Network Open

The MedSafer Study—Electronic Decision Support for Deprescribing in Hospitalized Older Adults: A Cluster Randomized Clinical Trial – JAMA Internal Medicine

Quantifying Anticholinergic Burden and Sedative Load in Older Adults with Polypharmacy: A Systematic Review of Risk Scales and Models – Drugs & Aging

Deprescribing in palliative patients with cancer: a concise review of tools and guidelines – Supportive Care in Cancer

Prescribing practices, patterns, and potential harms in patients receiving palliative care: A systematic scoping review – Exploratory Research in Clinical and Social Pharmacy

A narrative review of evidence to guide deprescribing among older adults – Journal of General and Family Medicine

Polypharmacy, inappropriate prescribing, and deprescribing in older people: through a sex and gender lens – The Lancet Health Longevity

Polypharmacy Management in Older Patients – Mayo Clinic Proceedings

Psychopharmacological Treatment in Older People: Avoiding Drug Interactions and Polypharmacy – Deutsches Ärzteblatt international

Eliminating Medication Overload: A National Action Plan – Lown Institute

International Group for Reducing Inappropriate Medication Use & Polypharmacy (IGRIMUP): Position Statement and 10 Recommendations for Action – Drugs & Aging

Common ED Medication Errors: Polypharmacy – emDocs

Current and future perspectives on the management of polypharmacy – BMC Family Practice

Routine deprescribing of chronic medications to combat polypharmacy – Therapeutic Advances in Drug Safety

Polypharmacy—an Upward Trend with Unpredictable Effects – Deutsches Ärzteblatt international

Clinical Consequences of Polypharmacy in Elderly – Expert Opinion on Drug Safety

 


M-A | The effect of blood pressure lowering medications on the prevention of episodic migraine

12 Jul, 2023 | 13:50h | UTC

The effect of blood pressure lowering medications on the prevention of episodic migraine: A systematic review and meta-analysis – Cephalalgia

News Release: New study shows common blood pressure meds underused for migraine – George Institute for Global Health

 


M-A | Cognitive rehabilitation may improve everyday activities in mild to moderate dementia

12 Jul, 2023 | 13:34h | UTC

Cognitive rehabilitation for people with mild to moderate dementia – Cochrane Library

 


Cohort Study | Long-term use of menopausal hormone therapy linked to heightened dementia risk

11 Jul, 2023 | 14:04h | UTC

Menopausal hormone therapy and dementia: nationwide, nested case-control study – The BMJ

Editorial: Menopausal hormone therapy and dementia – The BMJ

News Release: Menopausal hormone therapy linked to increased rate of dementia – BMJ Newsroom

Commentaries: Expert reaction to observational study on HRT and dementia – Science Media Centre

 


Subarachnoid hemorrhage | ED presentation, evaluation, and management

11 Jul, 2023 | 13:49h | UTC

Subarachnoid hemorrhage: ED presentation, evaluation, and management – emDocs

Related:

RCT | Use of lumbar drains improves 6-month outcomes in patients with aneurysmal subarachnoid hemorrhage

AHA/ASA Guideline for the management of patients with aneurysmal subarachnoid hemorrhage

Subarachnoid haemorrhage caused by a ruptured aneurysm: diagnosis and management – National Institute for Health and Care Excellence

Consensus Recommendations: Early management of patients with aneurysmal subarachnoid hemorrhage in a hospital with neurosurgical/neuroendovascular facilities.

Intracranial Pressure Monitoring and Management in Aneurysmal Subarachnoid Hemorrhage – Neurocritical Care

 


RCT | Butylphthalide may enhance functional outcomes in acute ischemic stroke patients undergoing reperfusion therapy

11 Jul, 2023 | 13:46h | UTC

Efficacy and Safety of Butylphthalide in Patients With Acute Ischemic Stroke: A Randomized Clinical Trial – JAMA Neurology (link to abstract – $ for full-text)

See also: Visual Abstract

 


RCT | Dual antiplatelet therapy proves noninferior to alteplase in minor ischemic stroke

10 Jul, 2023 | 13:58h | UTC

Dual Antiplatelet Therapy vs Alteplase for Patients With Minor Nondisabling Acute Ischemic Stroke: The ARAMIS Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

See also: Visual Abstract

Commentary: ARAMIS Clinical Trial Demonstrates the Noninferiority of Dual Antiplatelet Therapy Compared with Intravenous Activase in Patients with Minor Nondisabling Acute Ischemic Stroke – Practical Neurology

 


Review | Evaluation of acute adult disorders of consciousness for the general intensivist

10 Jul, 2023 | 13:37h | UTC

State-of-the-Art Evaluation of Acute Adult Disorders of Consciousness for the General Intensivist – Critical Care Medicine (free for a limited period)

 


Cohort Study | Hypertensive disorders of pregnancy linked to a 66% higher stroke risk in U.S. black women

10 Jul, 2023 | 13:31h | UTC

Hypertensive Disorders of Pregnancy and Risk of Stroke in U.S. Black Women – NEJM Medicine

Commentary: Black women with history of hypertensive disorders of pregnancy have 66% increased risk of stroke, study finds – News Medical

 


RCT | Semont-plus maneuver yields faster recovery than Epley maneuver in posterior canal BPPV

7 Jul, 2023 | 16:26h | UTC

The Semont-Plus Maneuver or the Epley Maneuver in Posterior Canal Benign Paroxysmal Positional Vertigo: A Randomized Clinical Study – JAMA Neurology (link to abstract – $ for full-text)

See also: Visual Abstract

Videos:

Demonstration of the Semont-Plus Self-maneuver for Right Posterior Canal Canalithiasis

Semont-Plus Maneuver for Right Posterior Canal Benign Paroxysmal Positional Vertigo

Demonstration of the Epley Self-maneuver for a Right Posterior Canal Canalithiasis

Commentary: Semont-plus Meneuver Offered Faster Recovery for Benign Paroxysmal Positional Vertigo – Neurology Today

 


Review | Respiratory challenges and ventilatory management in different types of acute brain-injured patients

3 Jul, 2023 | 14:17h | UTC

Respiratory challenges and ventilatory management in different types of acute brain-injured patients – Critical Care

 


M-A | Metoclopramide effective in acute migraine relief, comparable to most active drugs, superior to placebo

30 Jun, 2023 | 14:51h | UTC

The efficacy and safety of metoclopramide in relieving acute migraine attacks compared with other anti-migraine drugs: a systematic review and network meta-analysis of randomized controlled trials – BMC Neurology

 


M-A | Tracheostomy timing not a key determinant of clinical outcomes in critically ill stroke patients

30 Jun, 2023 | 14:50h | UTC

Tracheostomy timing and outcome in critically ill patients with stroke: a meta-analysis and meta-regression – Critical Care

 


Development and validation of an international preoperative risk assessment model for postoperative delirium

30 Jun, 2023 | 14:43h | UTC

Development and validation of an international preoperative risk assessment model for postoperative delirium – Age and Ageing

 


Review | Silent cerebral lesions following catheter ablation for atrial fibrillation

29 Jun, 2023 | 13:51h | UTC

Silent cerebral lesions following catheter ablation for atrial fibrillation: a state-of-the-art review – EP Europace

 

Commentary on Twitter

 


Choosing Wisely | Recommendations for advance care planning

22 Jun, 2023 | 15:18h | UTC

Choosing Wisely: Canadian Neurological Society Recommendations for Advance Care Planning – Canadian Journal of Neurological Sciences

See complete lists of low-value practices: Choosing Wisely U.S. / Choosing Wisely UK / Choosing Wisely Australia AND Choosing Wisely Canada

 


Review | Intracranial pressure monitoring and management in aneurysmal subarachnoid hemorrhage

22 Jun, 2023 | 15:02h | UTC

Intracranial Pressure Monitoring and Management in Aneurysmal Subarachnoid Hemorrhage – Neurocritical Care

 


M-A | No significant difference between thrombo-aspiration and stent-retrieval thrombectomy in ischemic stroke treatment

22 Jun, 2023 | 15:00h | UTC

Different types of percutaneous endovascular interventions for acute ischemic stroke – Cochrane Library

Summary: Different types of percutaneous endovascular treatments for acute ischemic stroke – Cochrane Library

 


RCT | Use of lumbar drains improves 6-month outcomes in patients with aneurysmal subarachnoid hemorrhage

20 Jun, 2023 | 12:55h | UTC

Effectiveness of Lumbar Cerebrospinal Fluid Drain Among Patients With Aneurysmal Subarachnoid Hemorrhage: A Randomized Clinical Trial – JAMA Neurology

See also: Visual Abstract

 

Commentary on Twitter

 


RCT | In chronic subdural hematoma, dexamethasone fails to match surgery for functional outcomes

20 Jun, 2023 | 12:53h | UTC

Dexamethasone versus Surgery for Chronic Subdural Hematoma – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Dexamethasone Compared to Burr-Hole Drainage for Chronic Subdural Hematoma – HealthDay

 


Guidelines for the management of trigeminal neuralgia

20 Jun, 2023 | 12:43h | UTC

Guidelines for the management of trigeminal neuralgia – Cleveland Clinic Journal of Medicine

 


Stay Updated in Your Specialty

Telegram Channels
Free

WhatsApp alerts 10-day free trial

No spam, just news.