Pharmacology/Pharmaceutical Industry
Overuse of medications in low- and middle-income countries: a scoping review
27 Jan, 2023 | 12:31h | UTC
Perspective | Were bivalent boosters worth it? The biggest questions about the newest Covid-19 vaccines are still unanswered
27 Jan, 2023 | 12:19h | UTC
SR | Barriers and facilitators to deprescribing of cardiovascular medications
27 Jan, 2023 | 12:09h | UTCRelated:
Review | The blood–brain barrier and optimization of antibiotics for the treatment of CNS infections in adults
27 Jan, 2023 | 11:55h | UTC
Essential medicines for mental disorders: comparison of 121 national lists with WHO recommendations
26 Jan, 2023 | 12:55h | UTC
SR | Medication review in hospitalized patients to reduce morbidity and mortality
24 Jan, 2023 | 14:37h | UTCMedication review in hospitalised patients to reduce morbidity and mortality – Cochrane Library
Summary: What are the benefits and risks of medication reviews for hospitalized adults? – Cochrane Library
Commentary on Twitter (thread – click for more)
In hospital medication review can help to reduce readmission: updated @CochraneLibrary review summarises latest evidence https://t.co/mrbIZRBs8b Let's look beyond headline & consider applicability….
— Toby Lasserson (@tlassers) January 23, 2023
FDA no longer needs to require animal tests before human drug trials
24 Jan, 2023 | 14:32h | UTCFDA no longer needs to require animal tests before human drug trials – Science
See also: The FDA no longer requires all drugs to be tested on animals before human trials – NPR
AHA Statement | Cancer therapy-related hypertension
23 Jan, 2023 | 13:46h | UTCTop Things to Know: Cancer Therapy-Related HTN – American Heart Association
Prescribing cascades: how to detect them, prevent them, and use them appropriately
23 Jan, 2023 | 13:41h | UTCRelated:
Evidence of a gabapentinoid and diuretic prescribing cascade among older adults with lower back pain – Journal of the American Geriatrics Society (link to abstract – $ for full-text)
Are you the victim of a prescribing cascade?
Prescribing Cascade in a Cardiology Practice
Recurrent venous thromboembolism and bleeding with extended anticoagulation: the VTE-PREDICT risk score
18 Jan, 2023 | 14:37h | UTCSee calculator: https://vtepredict.com/
Commentary on Twitter
The effect of extended anticoagulant treatment for individual patients with venous thromboembolism: the results from the VTE-PREDICT risk score! #venous #thromboembolism #anticoagulant #bleeding #score#EHJ #cardiotwitter @ESC_Journals @escardio
https://t.co/u3NHWyB9rv pic.twitter.com/ifOFxaXV1I— EHJ Editor-in-Chief (@ehj_ed) January 17, 2023
Cohort Study | Proton pump inhibitors are unlikely to be major teratogens during pregnancy
18 Jan, 2023 | 14:14h | UTC
Commentary on Twitter
This large nationwide cohort study of 2.7 million pregnancies suggested that maternal proton pump inhibitor use during pregnancy is not associated with an increased risk of congenital malformations. https://t.co/fvgthhIYa7
— JAMA Network Open (@JAMANetworkOpen) January 10, 2023
Cohort Study | Safety and effects of buprenorphine-naloxone, buprenorphine, and methadone throughout pregnancy in maternal opioid use disorder
18 Jan, 2023 | 14:10h | UTCCommentary: Buprenorphine-Naloxone Appears Safe for Maternal Opioid Use Disorder – HealthDay
Cohort Study | Antibiotic exposure linked to increased risk of inflammatory bowel disease
13 Jan, 2023 | 13:25h | UTCNews Release: Frequent use of antibiotics may heighten inflammatory bowel disease risk in over 40s – BMJ Newsroom
Commentaries:
Antibiotics may increase risk of inflammatory bowel disease, study finds – CIDRAP
Antibiotic Exposure Positively Linked to IBD Development – HealthDay
Commentary on Twitter
#GUTPressRelease on the paper by @AdamFayeMD, @KristineAllin, @manasiagrawalmd, @PREDICTIBD et al
"Antibiotic use as a risk factor for inflammatory bowel disease across the ages: a population-based cohort study" viahttps://t.co/zc9bG3CpSm#GUTInTheNews pic.twitter.com/xra8wfEgnr
— Gut Journal (@Gut_BMJ) January 9, 2023
RCT | A 24-week, all-oral regimen for rifampin-resistant tuberculosis
12 Jan, 2023 | 13:27h | UTCA 24-Week, All-Oral Regimen for Rifampin-Resistant Tuberculosis – New England Journal of Medicine
Commentary: Trial results show superiority of shorter, all-oral treatment for drug-resistant TB – CIDRAP
Circulating spike protein detected in post–COVID-19 mRNA vaccine myocarditis
11 Jan, 2023 | 14:30h | UTCCirculating Spike Protein Detected in Post–COVID-19 mRNA Vaccine Myocarditis – Circulation
Commentary: Free spike proteins in the blood appear to play a role in myocarditis post-COVID mRNA vaccine – News Medical
RCT | Effect of prescriber notifications of patient’s fatal overdose on opioid prescribing at 4 to 12 months
10 Jan, 2023 | 14:50h | UTC
Commentary on Twitter
Letters notifying clinicians of a patient's fatal overdose reduced opioid prescribing up to one year after receiving the letter. https://t.co/cEU1inH9lE
— JAMA Network Open (@JAMANetworkOpen) January 6, 2023
Consensus Paper | Antipsychotic medication deprescribing among adult patients with critical illness
10 Jan, 2023 | 14:37h | UTC
Commentary on Twitter
#CritCareExplore @SCCM Prescribing recommendations in ICU patients: limit antipsychotics to those with hyperactive delirium, at risk of harm to self/others or w/ care impacts. @n_jaworska@kiramakuk@KarlaKrewulak@dan_niven@lisa_burry@geetamehta0 @kmfiest https://t.co/73GUvrfJls pic.twitter.com/TbjbnGxD8Y
— Critical Care Explorations (@CritCareExplore) December 4, 2022
ACP Guideline | Pharmacologic treatment of primary osteoporosis or low bone mass to prevent fractures in adults
9 Jan, 2023 | 14:59h | UTCSummary for Patients: Pharmacologic Treatment of Primary Osteoporosis or Low Bone Mass to Prevent Fractures in Adults
WHO updates recommendations on HPV vaccination schedule
9 Jan, 2023 | 14:57h | UTCNews Release: WHO updates recommendations on HPV vaccination schedule – World Health Organization
Guideline: Human papillomavirus vaccines: WHO position paper, December 2022 – World Health Organization
Commentaries:
WHO supports 1-dose HPV vaccine strategy – CIDRAP
Commentary on Twitter
🆕 WHO has revised its recommendations on possible schedules for human papillomavirus (#HPV) vaccines & now recommends:
👉1 or 2-doses for girls & women aged 9-20
👉2 doses with a 6-month interval for women 21+https://t.co/m0KZyH6sPR pic.twitter.com/W4PeS4raV9— World Health Organization (WHO) (@WHO) December 21, 2022
Scientists tie third clinical trial death to experimental Alzheimer’s drug
9 Jan, 2023 | 14:47h | UTCScientists tie third clinical trial death to experimental Alzheimer’s drug – Science
Related: RCT | Lecanemab slows cognitive decline in early Alzheimer’s disease but raises safety concerns.
RCT | The addition of Olanzapine to a triple antiemetic regimen effectively prevents nausea and vomiting during highly emetogenic chemotherapy.
16 Dec, 2022 | 13:32h | UTCRelated:
Cohort Study | Assessment of depression and adherence to guideline-directed medical therapies following PCI.
14 Dec, 2022 | 14:59h | UTCCommentaries:
Cohort Study | Association of in utero antipsychotic medication exposure with risk of congenital malformations.
8 Dec, 2022 | 13:00h | UTCAssociation of In Utero Antipsychotic Medication Exposure With Risk of Congenital Malformations in Nordic Countries and the US – JAMA Psychiatry (free for a limited period)
Related:
Commentary on Twitter
New findings from a large cohort study including 26,000 antipsychotic-exposed pregnancies from 6 countries suggest that prenatal exposure to individual antipsychotics is generally not associated with an increase in risk of major congenital malformations https://t.co/4cUm8sXgsi
— JAMA Psychiatry (@JAMAPsych) December 7, 2022
ASCO Guideline | Use of opioids for adults with pain from cancer or cancer treatment.
7 Dec, 2022 | 14:32h | UTC
Case Report | Vitamin D intoxication and severe hypercalcemia complicating nutritional supplements misuse.
6 Dec, 2022 | 13:56h | UTCCommentaries:
Vitamin D supplement ‘overdosing’ is possible and harmful, warn doctors – Medical Dialogues
How an increasingly popular supplement landed a man in the hospital – CNN
You Can Take Too Much Vitamin D — One Man Found Out the Hard Way – HealthDay