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Pharmacology

Observational Study Suggests an Increased Risk of COVID-19 Among Users of Proton Pump Inhibitors

10 Jul, 2020 | 09:19h | UTC

Increased Risk of COVID-19 Among Users of Proton Pump Inhibitors – The American Journal of Gastroenterology

Commentaries: Increased Risk of COVID-19 Among Users of Proton Pump Inhibitors (PPIs) – American College of Gastroenterology AND Popular Heartburn Drugs Linked to Heightened COVID-19 Risk – TIME

 


[Abstract Only] Randomized Trial: Baloxavir Marboxil for Prophylaxis against Influenza in Household Contacts

9 Jul, 2020 | 09:22h | UTC

Baloxavir Marboxil for Prophylaxis against Influenza in Household Contacts – New England Journal of Medicine

Commentary: Baloxavir Helps Prevent Flu in Exposed Household Contacts – NEJM Journal Watch

 


Randomized Trial: Probiotic Use Does Not Reduce Antibiotic Administration Among Care Home Residents

9 Jul, 2020 | 09:20h | UTC

Effect of Probiotic Use on Antibiotic Administration Among Care Home Residents: A Randomized Clinical Trial – JAMA

Commentary: Probiotics do not reduce antibiotic prescribing in care home residents, shows study – University of Oxford

 

Related Commentary on Twitter

 


Methotrexate is Not an Additional Risk Factor for Interstitial Lung Disease in RA Patients

8 Jul, 2020 | 00:54h | UTC

Methotrexate is not an additional risk factor for interstitial lung disease in RA patients – News Medical

Related Review: Treatment of Rheumatoid Arthritis-Associated Interstitial Lung Disease: Lights and Shadows – Journal of Clinical Medicine

 


Meta-Analysis: Comparative Effectiveness of Biological Medicines in Rheumatoid Arthritis

8 Jul, 2020 | 00:53h | UTC

Comparative effectiveness of biological medicines in rheumatoid arthritis: systematic review and network meta-analysis including aggregate results from reanalysed individual patient data – The BMJ

Commentary: Lessons from a network meta-analysis of biologics in rheumatoid arthritis – The BMJ Opinion

 


Data Show Panic and Disorganization Dominate the Study of Covid-19 Drugs

7 Jul, 2020 | 09:02h | UTC

Data show panic and disorganization dominate the study of Covid-19 drugs – STAT

Related: Waste in covid-19 research – The BMJ AND Too much information, too little evidence: is waste in research fuelling the covid-19 infodemic? – The BMJ AND Urgent call for greater multilateralism and coordination of covid-19 trials – The BMJ

 


WHO: Access to HIV Medicines Severely Impacted by COVID-19 as AIDS Response Stalls

7 Jul, 2020 | 09:01h | UTC

WHO: access to HIV medicines severely impacted by COVID-19 as AIDS response stalls – World Health Organization

Commentary: Pandemic tops 11.5 million cases, imperils HIV care – CIDRAP

 


Developing a SARS-CoV-2 Vaccine at Warp Speed

7 Jul, 2020 | 08:59h | UTC

Developing a SARS-CoV-2 Vaccine at Warp Speed – JAMA

Related Video: Coronavirus Vaccine Development – JAMA

 


Podcast: A Clinical Pharmacologist’s Perspective on Penicillin Allergy

7 Jul, 2020 | 08:43h | UTC

A Clinical Pharmacologist’s Perspective on Penicillin Allergy – JAMA

 


ACMT Position Statement: Medication Administration and Safety During the Response to COVID-19 Pandemic

6 Jul, 2020 | 09:04h | UTC

ACMT Position Statement: Medication Administration and Safety During the Response to COVID-19 Pandemic – Journal of Medical Toxicology

 


WHO Discontinues Hydroxychloroquine and Lopinavir/Ritonavir Treatment Arms for COVID-19

6 Jul, 2020 | 09:02h | UTC

WHO discontinues hydroxychloroquine and lopinavir/ritonavir treatment arms for COVID-19 – World Health Organization

Commentary: WHO says trials show malaria and HIV drugs don’t cut Covid-19 hospital deaths – The Guardian

 

Related Commentary on Twitter

 


Study Publications Must Be Up-To-Date in Covid Time (Regarding the Latest Observational Hydroxychloroquine Study)

6 Jul, 2020 | 09:00h | UTC

Study Publications Must Be Up-To-Date in Covid Time – Absolutely Maybe Blog, by Hilda Bastian

Original Study: Treatment with Hydroxychloroquine, Azithromycin, and Combination in Patients Hospitalized with COVID-19 – International Journal of Infectious Diseases

 


Opinion – One U.K. Trial is Transforming COVID-19 Treatment. Why Haven’t Others Delivered More Results?

6 Jul, 2020 | 08:58h | UTC

One U.K. trial is transforming COVID-19 treatment. Why haven’t others delivered more results? – Science

Study 1 – lopinavir-ritonavir: No clinical benefit from use of lopinavir-ritonavir in hospitalised COVID-19 patients studied in RECOVERY

Study 2 – dexamethasone: Low-cost dexamethasone reduces death by up to one third in hospitalised patients with severe respiratory complications of COVID-19 – Recovery Trial AND Effect of Dexamethasone in Hospitalized Patients with COVID-19: Preliminary Report – medRxiv

Study 3 – hydroxychloroquine: No clinical benefit from use of hydroxychloroquine in hospitalised patients with COVID-19

 


Meta-analysis: The Safety and Efficacy of Aspirin Discontinuation on a Background of a P2Y12 Inhibitor in Patients after Percutaneous Coronary Intervention

6 Jul, 2020 | 08:27h | UTC

The Safety and Efficacy of Aspirin Discontinuation on a Background of a P2Y12 Inhibitor in Patients after Percutaneous Coronary Intervention: A Systematic Review and Meta-Analysis – Circulation

Commentaries: Short DAPT Reduces Bleeding With No Increase in MACE: Meta-analysis – TCTMD AND Discontinuing Aspirin on Background of P2Y12 Inhibitor After PCI – American College of Cardiology

 


Accelerating Development of SARS-CoV-2 Vaccines — The Role for Controlled Human Infection Models

2 Jul, 2020 | 08:49h | UTC

Accelerating Development of SARS-CoV-2 Vaccines — The Role for Controlled Human Infection Models – New England Journal of Medicine

Related: Challenge Trials—Could Deliberate Coronavirus Exposure Hasten Vaccine Development? – JAMA AND Opinion: Ethical Guidelines for Deliberately Infecting Volunteers with COVID-19 to Speed Vaccine Development (commentaries on the subject) AND Feasibility, potential value and limitations of establishing a closely monitored challenge model of experimental COVID-19 infection and illness in healthy young adult volunteers – World Health Organization (draft document for public comments) AND Human Challenge Studies to Accelerate Coronavirus Vaccine Licensure – The Journal of Infectious Diseases AND Ethics of controlled human infection to address COVID-19 – Science AND Extraordinary diseases require extraordinary solutions – Vaccine

 


Opinion: The Moral Imperative to Include Pregnant Women in Clinical Trials of Interventions for COVID-19

2 Jul, 2020 | 08:46h | UTC

The Moral Imperative to Include Pregnant Women in Clinical Trials of Interventions for COVID-19 – Annals of Internal Medicine

Related: Excluding pregnancy from COVID-19 trials: Protection from harm or the harm of protection? – Canadian Medical Association Journal

 


Evidence Does Not Support Vitamin D for Reducing Respiratory Infections, Reviews Conclude

2 Jul, 2020 | 08:42h | UTC

Evidence does not support vitamin D for reducing respiratory infections, reviews conclude – The BMJ

 


Randomized Trial: Amoxicillin for 3 Days Noninferior to Amoxicillin for 5 Days for Chest-Indrawing Pneumonia in Children

2 Jul, 2020 | 08:41h | UTC

Amoxicillin for 3 or 5 Days for Chest-Indrawing Pneumonia in Malawian Children – New England Journal of Medicine

Visual Abstract: Amoxicillin for 3 or 5 Days for Chest-Indrawing Pneumonia

Commentaries: Antibiotic use, duration questioned for kids’ pneumonia in low-resource areas – CIDRAP AND Three-day amoxicillin course effective for chest-indrawing pneumonia in Malawi children – 2 Minute Medicine

 


Randomized Trial of Amoxicillin vs. Placebo for Pneumonia in Children from Low-Income Communities

2 Jul, 2020 | 08:40h | UTC

Randomized Trial of Amoxicillin for Pneumonia in Pakistan – New England Journal of Medicine

 


[Abstract Only] Randomized Trial: Triple Inhaled Therapy at Two Glucocorticoid Doses in Moderate-to-Very-Severe COPD

2 Jul, 2020 | 08:39h | UTC

Triple Inhaled Therapy at Two Glucocorticoid Doses in Moderate-to-Very-Severe COPD – New England Journal of Medicine

Commentaries: Triple Therapy at 2 Doses Appears to Reduce COPD Exacerbations, Study Says – AJMC AND Triple Inhaled Therapy Aids in Moderate-to-Very Severe COPD – Physician’s Weekly

 


[Abstract Only] Randomized Trial: Early Vaginal Progesterone in Twin Pregnancies Does Not Prevent Spontaneous Preterm Birth

2 Jul, 2020 | 08:36h | UTC

Early vaginal progesterone versus Placebo in Twin Pregnancies for prevention of spontaneous preterm birth (EVENTS): A randomised double-blind trial – American Journal of Obstetrics & Gynecology (link to abstract – $ for full-text)

Related Studies: Randomized Trial: Progesterone in Women with Bleeding in Early Pregnancy (link to study and commentaries) AND Randomized Trial: Injectable 17-α-hydroxyprogesterone Not Effective for the Prevention of Recurrent Preterm Birth (link to study and commentaries)

 


Systematic Review: Systemic Defenses to Prevent Intravenous Medication Errors in Hospitals

2 Jul, 2020 | 08:32h | UTC

Systemic Defenses to Prevent Intravenous Medication Errors in Hospitals: A Systematic Review – Journal of Patient Safety

Commentary: Systemic defenses to prevent intravenous medication errors in hospitals: a systematic review – PSNet

 


[Abstract Only] Meta-analysis: Comparative Effectiveness of Glucose-Lowering Drugs for Type 2 Diabetes

1 Jul, 2020 | 07:28h | UTC

Comparative Effectiveness of Glucose-Lowering Drugs for Type 2 Diabetes: A Systematic Review and Network Meta-analysis – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Meta-Analysis Aims to Compare Antidiabetic Medications in T2D Population – AJMC AND Metformin-based therapy should be first-line treatment for patients with type 2 diabetes at low cardiovascular risk – American College of Physicians

 


Press Release: No Clinical Benefit from Use of Lopinavir-ritonavir in Hospitalized COVID-19 Patients

30 Jun, 2020 | 08:08h | UTC

No clinical benefit from use of lopinavir-ritonavir in hospitalised COVID-19 patients studied in RECOVERY

Commentary: Expert reaction to statement from RECOVERY trial on lopinavir-ritonavir in hospitalised COVID-19 patients, reporting no clinical benefit – Science Media Centre

 


NICE Evidence Summary: Vitamin D Not Indicated to Prevent or Treat COVID-19

30 Jun, 2020 | 07:56h | UTC

COVID-19 rapid evidence summary: vitamin D for COVID-19 – National Institute for Health and Care Excellence

 


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