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Pharmacology/Pharmaceutical Industry

Presented at ASRS Meeting | Studies link GLP-1 agonists to progression of diabetic retinopathy

11 Aug, 2023 | 15:38h | UTC

Studies link GLP-1 agonists to progression of diabetic retinopathy – MDedge


M-A | Pharmacist-led home BP telemonitoring enhances control over usual care

11 Aug, 2023 | 15:29h | UTC

Adding Pharmacist-Led Home Blood Pressure Telemonitoring to Usual Care for Blood Pressure Control: A Systematic Review and Meta-Analysis – American Journal of Cardiology


Review | Adverse effects of antidepressant medications and their management in children and adolescents

9 Aug, 2023 | 15:25h | UTC

Adverse Effects of Antidepressant Medications and their Management in Children and Adolescents – Pharmacotherapy


M-A | Absence of evidence for antipsychotics in youth unipolar depression; limited evidence in bipolar depression

9 Aug, 2023 | 15:23h | UTC

Effectiveness of atypical antipsychotics for unipolar and bipolar depression in adolescents and young adults: A systematic review and meta-analysis – Journal of Affective Disorders


M-A | Nearly 37% of elderly outpatients are at risk due to potentially inappropriate medication use

8 Aug, 2023 | 13:37h | UTC

Prevalence of Use of Potentially Inappropriate Medications Among Older Adults Worldwide: A Systematic Review and Meta-Analysis – JAMA Network Open


Perspective | Will unpredictable side effects dim the promise of new Alzheimer’s drugs?

8 Aug, 2023 | 13:30h | UTC

Will unpredictable side effects dim the promise of new Alzheimer’s drugs? – Science (a few articles per month are free)


RCT | Donanemab slows early symptomatic Alzheimer’s progression, but raises serious safety concerns

RCT | Lecanemab slows cognitive decline in early Alzheimer’s disease but raises safety concerns


Cohort Study | Habitual calcium supplementation linked to higher CVD incidence and mortality in diabetics

8 Aug, 2023 | 13:24h | UTC

Associations of Habitual Calcium Supplementation With Risk of Cardiovascular Disease and Mortality in Individuals With and Without Diabetes – Diabetes Care (link to abstract – $ for full-text)

Related: The Evidence and Controversy Between Dietary Calcium Intake and Calcium Supplementation and the Risk of Cardiovascular Disease: A Systematic Review and Meta-Analysis of Cohort Studies and Randomized Controlled Trials – Journal of the American College of Nutrition


Commentary on Twitter


Opinion Video | Critical analysis of the data behind Covid-19 booster shots

31 Jul, 2023 | 14:40h | UTC

“FLAWED Booster data was used by FDA for Mass Vax Campaign & We PROVE it in our new PAPER” – YouTube Video by Dr Vinay Prassad

Original Publication: Correspondence | Potential “healthy vaccinee bias” in a study of BNT162b2 vaccine against Covid-19


New WHO lists of essential medicines

28 Jul, 2023 | 14:23h | UTC

News Release: WHO endorses landmark public health decisions on Essential Medicines for Multiple Sclerosis – World Health Organization

Lists of Essential Medicines

Model Lists of Essential Medicines – World Health Organization

Model Lists of Essential Medicines for Children – World Health Organization


Commentary on Twitter


Study | Only 11% of sports supplements listing botanical ingredients accurately declare contents, 12% contain FDA-prohibited stimulants

28 Jul, 2023 | 14:21h | UTC

Presence and Quantity of Botanical Ingredients With Purported Performance-Enhancing Properties in Sports Supplements – JAMA Network Open


Ensuring the Safety and Value of Supplements – JAMA Network Open

Sports Supplements Can Be Contaminated with Botanical Stimulants and Anabolic Agents – NEJM Journal Watch


BMJ Investigation | Medical royal colleges receive millions from drug and medical devices companies

28 Jul, 2023 | 14:19h | UTC

Medical royal colleges receive millions from drug and medical devices companies – The BMJ

News Release: Medical royal colleges receive millions from drug/medical device companies – BMJ Newsroom


Commentary on Twitter


Position Paper | Prioritizing deprescribing in fall prevention strategies

28 Jul, 2023 | 14:12h | UTC

European position paper on polypharmacy and fall-risk-increasing drugs recommendations in the World Guidelines for Falls Prevention and Management: implications and implementation – European Geriatric Medicine

Original Guideline: World guidelines for falls prevention and management for older adults: a global initiative – Age and Ageing


RCT | Vitamin D supplementation shows no cognitive benefit in mild cognitive impairment intervention

25 Jul, 2023 | 14:00h | UTC

Effects of Exercise Alone or Combined With Cognitive Training and Vitamin D Supplementation to Improve Cognition in Adults With Mild Cognitive Impairment: A Randomized Clinical Trial – JAMA Network Open

Commentary: Exercise and Cognitive Training Slow Thinking Declines. Vitamin D? Not So Much – HealthDay


RCT | No statistically significant impact of vitamin D on major cardiovascular events

2ry analysis of a RCT | Vitamin D supplementation does not affect cognitive function in older adults

RCT: Oral Vitamin D supplementation (60.000 IU per month) did not reduce mortality in patients 60 years or older (unscreened individuals in Australia, many without insufficiency, average 30ng/mL). Exploratory analyses pointed towards an increased risk of death from cancer.

Randomized Trial: Vitamin D Supplements and Prevention of Cancer and Cardiovascular Disease

Meta-Analysis: Vitamin D Not Effective for Cardiovascular Disease Prevention

Association between vitamin D supplementation and mortality: systematic review and meta-analysis – The BMJ

USPSTF Draft Statement: Insufficient evidence to recommend multivitamin supplements for the prevention of CVD or cancer. The statement also recommends against the use of beta-carotene (increases risk of CVD mortality and lung cancer) or vitamin E (clear evidence of no benefit)

Vitamin D, calcium, other vitamins, and supplements do not prevent cardiovascular diseases


Systematic Review | Moderate evidence supports interactive mobile phone interventions for contraception use enhancement

25 Jul, 2023 | 13:25h | UTC

Mobile phone‐based interventions for improving contraception use – Cochrane Library


Review | Research on prescribing cascades

24 Jul, 2023 | 12:53h | UTC

Research on prescribing cascades: a scoping review – Frontiers in Pharmacology


Correspondence | Potential “healthy vaccinee bias” in a study of BNT162b2 vaccine against Covid-19

21 Jul, 2023 | 13:43h | UTC

Potential “Healthy Vaccinee Bias” in a Study of BNT162b2 Vaccine against Covid-19 – New England Journal of Medicine


Commentary from the author on Twitter (thread – click for more)


Phase 1 Trial | Zilebesiran demonstrates potential as prolonged-action hypertension therapeutic

21 Jul, 2023 | 13:32h | UTC

Zilebesiran, an RNA Interference Therapeutic Agent for Hypertension – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Experimental Shot Given Every Six Months Controlled High Blood Pressure in Early Trial – HealthDay


IDSA 2023 Guidance on the treatment of antimicrobial resistant gram-negative infections

20 Jul, 2023 | 11:15h | UTC

Infectious Diseases Society of America 2023 Guidance on the Treatment of Antimicrobial Resistant Gram-Negative Infections – Clinical Infectious Diseases


Systematic Review | Outcomes in deprescribing implementation trials and compliance with expert recommendations

20 Jul, 2023 | 10:55h | UTC

Outcomes in deprescribing implementation trials and compliance with expert recommendations: a systematic review – BMC Geriatrics


Clinical practice guideline for deprescribing opioid analgesics: summary of recommendations – Medical Journal of Australia

RCT | Opioids not more effective than placebo for acute low back and neck pain

Deprescribing considerations for older people in general practice – Australian Journal of General Practice

Deprescribing Strategies for Opioids and Benzodiazepines with Emphasis on Concurrent Use: A Scoping Review – Journal of Clinical Medicine

An Overview of Systematic Reviews and Meta-Analyses on the Effect of Medication Interventions Targeting Polypharmacy for Frail Older Adults – Journal of Clinical Medicine

Physician-led medication reviews in polypharmacy patients treated with at least 12 medications in a type 2 diabetes outpatient clinic: a randomised trial – Diabetic Medicine

RCT | A deprescribing intervention reduced medication burden among older adults in post-acute care

Achieving sustainable healthcare through deprescribing of unnecessary medications: making sense of the evidence – Cochrane Library

Deprescribing medicines in older people living with multimorbidity and polypharmacy: the TAILOR evidence synthesis – Health Technology Assessment

Barriers and facilitators to deprescribing of cardiovascular medications: a systematic review – BMJ Open

A National Modified Delphi Consensus Process to Prioritize Experiences and Interventions for Antipsychotic Medication Deprescribing Among Adult Patients With Critical Illness – Critical Care Explorations

Deprescribing proton pump inhibitors – Australian Journal of General Practice

Medication reviews and deprescribing as a single intervention in falls prevention: a systematic review and meta-analysis – Age and Ageing

Optimizing Medication Use in Older Adults With Rheumatic Musculoskeletal Diseases: Deprescribing as an Approach When Less May Be More – ACP Open Rheumatology

Facing the challenge of polypharmacy when prescribing for older people with cardiovascular disease. A review by the European Society of Cardiology Working Group on Cardiovascular Pharmacotherapy – European Heart Journal – Cardiovascular Pharmacotherapy

Deprescribing in Older Adults with Cardiovascular Disease – Journal of the American College of Cardiology

Multimorbidity in Older Adults with Cardiovascular Disease – American College of Cardiology, Latest in Cardiology

Antihypertensive Deprescribing in Older Adults: a Practical Guide – Current Hypertension Reports

How-to guide for medication reviews in older adults with cancer: A Young International Society of Geriatric Oncology and Nursing & Allied Health Interest Group initiative – Journal of Geriatric Oncology

Deprescribing in Palliative Cancer Care – Life

Less is More: Deprescribing Medications in Older Adults with Kidney Disease: A Review – Kidney360

Process evaluation of implementation strategies to reduce potentially inappropriate medication prescribing in older population: A scoping review – Research in Social and Administrative Pharmacy

AGA Clinical Practice Update on De-Prescribing of Proton Pump Inhibitors: Expert Review – Gastroenterology

Development of a Metric to Detect and Decrease Low-Value Prescribing in Older Adults – JAMA Network Open

The MedSafer Study—Electronic Decision Support for Deprescribing in Hospitalized Older Adults: A Cluster Randomized Clinical Trial – JAMA Internal Medicine

Quantifying Anticholinergic Burden and Sedative Load in Older Adults with Polypharmacy: A Systematic Review of Risk Scales and Models – Drugs & Aging

Deprescribing in palliative patients with cancer: a concise review of tools and guidelines – Supportive Care in Cancer

Prescribing practices, patterns, and potential harms in patients receiving palliative care: A systematic scoping review – Exploratory Research in Clinical and Social Pharmacy

A narrative review of evidence to guide deprescribing among older adults – Journal of General and Family Medicine

Polypharmacy, inappropriate prescribing, and deprescribing in older people: through a sex and gender lens – The Lancet Health Longevity

Polypharmacy Management in Older Patients – Mayo Clinic Proceedings

Psychopharmacological Treatment in Older People: Avoiding Drug Interactions and Polypharmacy – Deutsches Ärzteblatt international

Eliminating Medication Overload: A National Action Plan – Lown Institute

International Group for Reducing Inappropriate Medication Use & Polypharmacy (IGRIMUP): Position Statement and 10 Recommendations for Action – Drugs & Aging

Common ED Medication Errors: Polypharmacy – emDocs

Current and future perspectives on the management of polypharmacy – BMC Family Practice

Routine deprescribing of chronic medications to combat polypharmacy – Therapeutic Advances in Drug Safety

Polypharmacy—an Upward Trend with Unpredictable Effects – Deutsches Ärzteblatt international

Clinical Consequences of Polypharmacy in Elderly – Expert Opinion on Drug Safety


FDA approves first nonprescription daily oral contraceptive

19 Jul, 2023 | 14:25h | UTC

FDA Approves First Nonprescription Daily Oral Contraceptive – U.S. Food & Drug Administration

Commentary: FDA approves first daily over-the-counter birth control pill, Opill – a pharmacist and public health expert explain this new era in contraception – The Conversation


RCT | Direct oral challenge noninferior to skin testing followed by direct oral challenge in low-risk penicillin allergy patients

18 Jul, 2023 | 13:54h | UTC

Efficacy of a Clinical Decision Rule to Enable Direct Oral Challenge in Patients With Low-Risk Penicillin Allergy: The PALACE Randomized Clinical Trial – JAMA Internal Medicine (free for a limited period)

See also: Visual Abstract

News Release: World-first clinical trial to help millions with penicillin allergies – Vanderbilt University Medical Center

Commentary: Trial supports use of direct oral challenge for penicillin allergy – CIDRAP


RCT | Donanemab slows early symptomatic Alzheimer’s progression, but raises serious safety concerns

18 Jul, 2023 | 13:51h | UTC

Donanemab in Early Symptomatic Alzheimer Disease: The TRAILBLAZER-ALZ 2 Randomized Clinical Trial – JAMA (free for a limited period)


Donanemab for Alzheimer Disease—Who Benefits and Who Is Harmed? – JAMA (free for a limited period)

Amyloid-Targeting Monoclonal Antibodies for Alzheimer Disease – JAMA (free for a limited period)

Ushering in a New Era of Alzheimer Disease Therapy – JAMA (free for a limited period)

See also: Visual Abstract

Commentary: Expert reaction to results from Eli Lilly on its anti-amyloid drug donanemab – Science Media Centre

Related: RCT | Lecanemab slows cognitive decline in early Alzheimer’s disease but raises safety concerns.


Guideline | Antibiotic therapy in patients with suspected antibiotic allergy

17 Jul, 2023 | 13:59h | UTC

The Dutch Working Party on Antibiotic Policy (SWAB) guideline for the approach to suspected antibiotic allergy – Clinical Microbiology and Infection


Retrospective Analysis | Inconsistencies in pediatric drug dosing found in over half of prehospital emergency drug administrations

17 Jul, 2023 | 13:50h | UTC

Deviation From National Dosing Recommendations for Children Having Out-of-hospital Emergencies – Pediatrics


Children and Drug Dosing Variations When in Transit to the Hospital – AAP Journals Blog

Variation Seen in Dosing of Meds at Prehospital Pediatric Encounters – HealthDay


Cohort Study | Long-acting antiretroviral therapy may achieve virologic suppression in HIV patients with adherence challenges

17 Jul, 2023 | 13:26h | UTC

Demonstration Project of Long-Acting Antiretroviral Therapy in a Diverse Population of People With HIV – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentary: Long-Acting ART Achieves Virologic Suppression for People With HIV – HealthDay


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