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Pharmacology / Pharmaceutical Industry

CDC Report: Reduction in severe COVID-19 following the implementation of a national vaccination program in Israel

28 Feb, 2021 | 21:54h | UTC

Reduction in COVID-19 Patients Requiring Mechanical Ventilation Following Implementation of a National COVID-19 Vaccination Program — Israel, December 2020–February 2021 – CDC Morbidity and Mortality Weekly Report

Commentary: Israeli data suggest mass vaccinations led to drop in severe Covid cases, CDC study finds – CNBC

 

Commentary on Twitter

 

Short Review: SARS-CoV-2 Vaccines

28 Feb, 2021 | 21:52h | UTC

SARS-CoV-2 Vaccines – JAMA

Author interview: Coronavirus Vaccines—An Overview

 

 

Studies: Single dose of vaccine acts as ‘booster’ in those with prior COVID-19 infection

28 Feb, 2021 | 21:49h | UTC

Single dose of vaccine acts as ‘booster’ in those with prior COVID-19 infection – Imperial College London

Study 1: Antibody response to first BNT162b2 dose in previously SARS-CoV-2-infected individuals – The Lancet

Study 2: Effect of previous SARS-CoV-2 infection on humoral and T-cell responses to single-dose BNT162b2 vaccine – The Lancet

 

Commentary on Twitter (thread – click for more)

 

Spain to give just one vaccine dose to under 55-year olds who had COVID-19

28 Feb, 2021 | 21:47h | UTC

Spain to give just one vaccine dose to under 55-year olds who had COVID-19 – Reuters

Related: Is One Vaccine Dose Enough After COVID-19 Infection? – NIH Director’s Blog AND France’s health authority recommends single vaccine shot for people who have had COVID-19

 

New report reviews methods for reducing waste, improving efficiency with expensive injectable medications

28 Feb, 2021 | 21:29h | UTC

New Report Reviews Methods for Reducing Waste, Improving Efficiency With Expensive Injectable Medications – The ASCO Post

Summary: Medications in Single-Dose Vials and Implications of Discarded Injectable Drugs: A National Academies Report – JAMA

Original report: Medications in Single Dose Vials: Implications of Discarded Drugs (2021) – National Academies of Sciences, Engineering, and Medicine

 

Commentary on Twitter

 

RCT: Baclofen reduces agitation in patients with unhealthy alcohol use receiving mechanical ventilation, but results in a longer time receiving mechanical ventilation and more extended ICU stay

28 Feb, 2021 | 21:09h | UTC

Effect of High-Dose Baclofen on Agitation-Related Events Among Patients With Unhealthy Alcohol Use Receiving Mechanical Ventilation: A Randomized Clinical Trial – JAMA

Editorial: Baclofen to Prevent Agitation Caused by Alcohol Withdrawal in the ICU

Video presentation: Effect of Baclofen on Agitation-Related Events Among Mechanically Ventilated Patients With Alcohol Use Disorder

 

Commentary on Twitter

 

RCT: Balanced opioid-free anesthesia with Dexmedetomidine resulted in a greater incidence of serious adverse events, especially hypoxemia and bradycardia

28 Feb, 2021 | 21:03h | UTC

Balanced Opioid-free Anesthesia with Dexmedetomidine versus Balanced Anesthesia with Remifentanil for Major or Intermediate Noncardiac Surgery: The Postoperative and Opioid-free Anesthesia (POFA) Randomized Clinical Trial – Anesthesiology

 

Bioethics | Should clinical guidelines incorporate cost pathways for persons with financial hardship?

28 Feb, 2021 | 20:54h | UTC

Should Clinical Guidelines Incorporate Cost Pathways for Persons With Financial Hardship? – AMA Journal of Ethics

 

Systematic Review: Cardiovascular Effects of Medical Marijuana

28 Feb, 2021 | 20:48h | UTC

Cardiovascular Effects of Medical Marijuana: A Systematic Review – The American Journal of Medicine

 

PRO-CON Debate: Are Carbapenems necessary for all infections caused by ceftriaxone-resistant Enterobacterales?

28 Feb, 2021 | 20:43h | UTC

PRO: Carbapenems should be used for ALL infections caused by ceftriaxone-resistant Enterobacterales – JAC-Antimicrobial Resistance

CON: Carbapenems are NOT necessary for all infections caused by ceftriaxone-resistant Enterobacterales – JAC-Antimicrobial Resistance

Editorial: Navigating treatment approaches for presumed ESBL-producing infections

 

Commentary on Twitter (thread – click for more)

 

Joint Statement: Hydroxychloroquine use with respect to retinal toxicity

28 Feb, 2021 | 20:41h | UTC

ACR, AAD, RDS, and AAO 2020 Joint Statement on Hydroxychloroquine Use with Respect to Retinal Toxicity – Arthritis & Rheumatism

Commentary: Societies Agree on Eye Safety for HCQ – MedPage Today (free registration required) AND ACR, medical societies reach consensus on hydroxychloroquine retinopathy – Healio (free registration required)

 

Commentary on Twitter

 

Indian Guidelines for pediatric skin care in neonates, infants, and children

28 Feb, 2021 | 20:37h | UTC

Indian Academy of Pediatrics Guidelines for Pediatric Skin Care

 

U.S. Guidelines panel recommendation for long-acting injectable antiretroviral regimen in adults and adolescents with HIV

28 Feb, 2021 | 20:34h | UTC

HHS Adults and Adolescents Antiretroviral Guidelines Panel Recommendation for the Long-Acting Injectable Antiretroviral Regimen of Cabotegravir and Rilpivirine – HIV.gov

What’s New in the Guidelines? Panel’s Recommendation for Long-Acting Injectable Cabotegravir and Rilpivirine in Persons with HIV

 

Conflicting results from 2 randomized trials testing Tocilizumab for Covid-19

26 Feb, 2021 | 08:48h | UTC

Study 1: Tocilizumab in Hospitalized Patients with Severe Covid-19 Pneumonia – New England Journal of Medicine

Study 2: Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19 – New England Journal of Medicine

Editorial: Interleukin-6 Receptor Inhibition in Covid-19 — Cooling the Inflammatory Soup – New England Journal of Medicine

 

Commentary on Twitter

 

Real-world data confirms Pfizer-BioNTech vaccine effectiveness

25 Feb, 2021 | 09:09h | UTC

BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Mass Vaccination Setting – New England Journal of Medicine

Audio Interview: The Real-World Effectiveness of Covid-19 Vaccination – New England Journal of Medicine

Commentaries: Real-world trial of Pfizer COVID vaccine finds high 2-dose, good 1-dose protection – CIDRAP AND Pfizer-BioNTech vaccine performs as well in the real world as in clinical trials, new study concludes – STAT AND In boost for COVID-19 battle, Pfizer vaccine found 94% effective in real world – Reuters AND Expert reaction to NEJM paper on Pfizer-BioNTech vaccine roll-out in Israel and COVID-19 outcomes – Science Media Centre

 

Commentary on Twitter (thread – click for more)

 

Ghana receives first historic shipment of COVID-19 vaccinations from international COVAX facility

25 Feb, 2021 | 09:12h | UTC

Ghana receives first historic shipment of COVID-19 vaccinations from international COVAX facility – UN News

See also: Ghana becomes recipient of historic first shipment of COVAX vaccines – World Health Organization

Commentaries: Covax vaccine-sharing scheme delivers first doses to Ghana – BBC AND Covax delivers first Covid vaccines in ‘momentous occasion’ – The Guardian AND COVAX delivers its first vaccine shots with shipment to Ghana – Reuters

 

Phase 2 trial: Muscarinic cholinergic receptor agonist and peripheral antagonist for schizophrenia

26 Feb, 2021 | 08:30h | UTC

Muscarinic Cholinergic Receptor Agonist and Peripheral Antagonist for Schizophrenia – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Phase II Results Promising for New Schizophrenia Drug Combo – MedPage Today

 

RCT: Dimenhydrinate and metoclopramide equally effective in the treatment of nausea due to vertigo

26 Feb, 2021 | 08:12h | UTC

Comparison of efficacy dimenhydrinate and metoclopramide in the treatment of nausea due to vertigo; a randomized study – The American Journal of Emergency Medicine (link to abstract – $ for full-text)

 

Series of n-of-1 trials show no difference in muscle symptoms in patients receiving placebo or statins

25 Feb, 2021 | 08:54h | UTC

Statin treatment and muscle symptoms: series of randomised, placebo controlled n-of-1 trials – The BMJ

Commentary: Do statins cause muscle symptom side effects? – The BMJ Opinion AND Study: Muscle Symptoms Didn’t Differ Between Statin and Placebo Periods – NEJM Journal Watch

Related study: #AHA20 – In patients who had discontinued statins because of side effects, a N-of-1 trial of a statin, placebo, or no treatment found that side effects often attributed to statins were the same for those taking a placebo (study and commentaries)

 

RCT: Effect of high-dose subcutaneous Semaglutide vs. placebo in adults with overweight or obesity

25 Feb, 2021 | 08:52h | UTC

Effect of Subcutaneous Semaglutide vs Placebo as an Adjunct to Intensive Behavioral Therapy on Body Weight in Adults With Overweight or Obesity: The STEP 3 Randomized Clinical Trial – JAMA

Commentary: Semaglutide paired with intensive behavioral therapy showed triple weight loss vs placebo – University of Pennsylvania School of Medicine

Related study: Once-weekly, high-dose semaglutide is effective for improving overweight or obesity among non-diabetic adults – New England Journal of Medicine (study and commentary)

 

Commentary on Twitter

 

[Not published yet] Covid-19 vaccine made by China’s Sinopharm has an efficacy rate of 72.5 percent

25 Feb, 2021 | 09:07h | UTC

Covid-19 vaccines made by China’s Sinopharm, CanSino release efficacy data – South China Morning Post

See also: Sinopharm’s Wuhan unit reports 72.5% efficacy for COVID shot, seeks approval in China – Reuters

 

Commentary on Twitter

 

FDA scientists endorse J&J’s Covid vaccine, as new data shed light on efficacy

25 Feb, 2021 | 09:06h | UTC

FDA scientists endorse J&J’s Covid vaccine, as new data shed light on efficacy – STAT

See also: FDA says single-dose shot from J&J prevents severe COVID – MedicalXpress

 

Why COVID vaccines are so difficult to compare

25 Feb, 2021 | 09:02h | UTC

Why COVID vaccines are so difficult to compare – Nature

 

Interview: The scientist who’s been right about Covid-19 vaccines predicts what’s next

25 Feb, 2021 | 09:01h | UTC

The scientist who’s been right about Covid-19 vaccines predicts what’s next – Vox

 

Commentary on Twitter (thread – click for more)

 

Position Paper: Management of drug-induced liver injury

25 Feb, 2021 | 08:27h | UTC

Drug-induced liver injury: A management position paper from the Latin American Association for Study of the liver – Annals of Hepatology

 

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