Pharmacology/Pharmaceutical Industry
Chimeric antigen receptor T cell therapy for cancer: clinical applications and practical considerations.
23 Sep, 2022 | 13:07h | UTC
Commentary on Twitter
Chimeric antigen receptor T cells have revolutionised the treatment of hematological malignancies.
What practical aspects of a patient’s journey through this treatment should clinicians know about and what are current best practices to manage toxicities?https://t.co/idlA2Lv9uR
— The BMJ (@bmj_latest) September 4, 2022
M-A of the association between new hypoglycemic agents and digestive diseases.
22 Sep, 2022 | 13:16h | UTCMeta-analysis of the association between new hypoglycemic agents and digestive diseases – Medicine
Commentary: Spotlight on digestive risks of newer diabetes drugs – ACP Gastroenterology
A quality improvement study showed that a clinic–based aspirin deimplementation intervention can reduce inappropriate aspirin prescribing and bleeding in patients receiving warfarin for anticoagulation.
22 Sep, 2022 | 13:14h | UTCNews Release: Stopping aspirin when on a blood thinner lowers risk of bleeding, study finds – Michigan Medicine
Commentary on Twitter
An anticoagulation clinic–based #aspirin deimplementation intervention was associated with improved guideline-concordant aspirin use and fewer bleeding complications. https://t.co/kxKFZOdhae #Research
— JAMA Network Open (@JAMANetworkOpen) September 19, 2022
Observational study suggests an increased risk of adverse events with the use of perioperative Gabapentin for pain management.
21 Sep, 2022 | 13:20h | UTCPerioperative Gabapentin Use and In-Hospital Adverse Clinical Events Among Older Adults After Major Surgery – JAMA Internal Medicine (free for a limited period)
Invited Commentary: Perioperative Gabapentin Use in Older Adults: Revisiting Multimodal Pain Management – JAMA Internal Medicine (free for a limited period)
Commentary on Twitter
Study suggests that careful risk-benefit assessment is needed before prescribing #gabapentin for perioperative #PainManagement to older patients. https://t.co/GDxupdEjeT #Research
— JAMA Internal Medicine (@JAMAInternalMed) September 19, 2022
Review | Obesity and contraceptive use: impact on cardiovascular risk.
16 Sep, 2022 | 12:53h | UTCObesity and contraceptive use: impact on cardiovascular risk – ESC Heart Failure
News Release: Combined birth control pill linked with increased risk of blood clots in obese women – European Society of Cardiology
Study | Vitamin D3 and omega-3 fatty acids not helpful in reducing the risk of frailty.
14 Sep, 2022 | 13:20h | UTCNews Release: Vitamin D3 and omega-3 fatty acids not helpful in reducing risk of frailty – Brigham and Women’s Hospital
Invited Commentary: There Is No Magic Pill to Prevent Frailty—You Still Have to Eat Your Vegetables – JAMA Network Open
Commentary on Twitter
New findings from the VITAL trial do not support the routine use of vitamin D3 or omega-3 fatty acid supplementation in community-dwelling older adults for the prevention of frailty. #OAResearch https://t.co/LIJO8bJ0Wk #OAResearch
— JAMA Network Open (@JAMANetworkOpen) September 13, 2022
Network M-A | Comparative efficacy of lipid‐lowering therapies added to maximally tolerated statins for the reduction of LDL cholesterol.
11 Sep, 2022 | 22:38h | UTC
Nonadherence was revealed through measurements of serum concentrations of antihypertensive drugs in one-third of patients with resistant hypertension previously evaluated as adherent.
11 Sep, 2022 | 22:35h | UTC
Guideline Summary | Management of patients with suspected or confirmed antibiotic allergy.
8 Sep, 2022 | 14:42h | UTCRelated:
M-A: Most patients with allergy to Penicillin can be given Cefazolin
Podcast: A Clinical Pharmacologist’s Perspective on Penicillin Allergy
Study: Development and Validation of a Penicillin Allergy Clinical Decision Rule
NICE: Double Check Patients with ‘Penicillin Allergy’ to Avoid Increased MRSA Risk
Perspective | Psychedelic drugs take on depression.
8 Sep, 2022 | 14:32h | UTCPsychedelic drugs take on depression – Nature
Systematic Review | Probiotics for preventing acute upper respiratory tract infections.
6 Sep, 2022 | 14:40h | UTCProbiotics for preventing acute upper respiratory tract infections – Cochrane Library
Commentary on Twitter
#probiotics for preventing colds? @CochraneARI looked at 24 studies w 6,950 people.
👍 may be beneficial in preventing at least 1 occurrence of acute upper respiratory tract infection #URTI & likely beneficial in preventing 3 occurrences of URTIs.https://t.co/A6XxrjKKcI pic.twitter.com/mDR3NYLLzQ— The Cochrane Library (@CochraneLibrary) August 24, 2022
Study raises concerns about the effectiveness of the monkeypox vaccine.
6 Sep, 2022 | 14:39h | UTCStudy raises concerns about the effectiveness of the monkeypox vaccine – STAT
Original Study (Preprint): Low levels of monkeypox virus neutralizing antibodies after MVA-BN vaccination in healthy individuals – medRxiv
Systematic Review | Opioid agonist treatment for people who are dependent on pharmaceutical opioids.
6 Sep, 2022 | 14:31h | UTCOpioid agonist treatment for people who are dependent on pharmaceutical opioids – Cochrane Library
Review | Cardiovascular complications of immune checkpoint inhibitors for cancer.
6 Sep, 2022 | 14:20h | UTCCardiovascular complications of immune checkpoint inhibitors for cancer – European Heart Journal
Related:
Cardiotoxicity of immune checkpoint inhibitors – ESMO Open
Cardiotoxicity from immune checkpoint inhibitors – IJC Heart & Vasculature
Commentary on Twitter
Must read state-of-the-art review: Cardiovascular complications of immune checkpoint inhibitors for cancer https://t.co/0lr7g6s8g0
#EHJ #ESCYoung #cardiotwitter @ehj_ed @rladeiraslopes pic.twitter.com/jORaTzP7GD— European Society of Cardiology Journals (@ESC_Journals) September 5, 2022
Consensus Statement | Preoperative management of cardiovascular medications.
5 Sep, 2022 | 14:42h | UTCRelated:
Preoperative Management of Medications for Neurologic Diseases – Mayo Clinic Proceedings
Preoperative Management of Surgical Patients Using Dietary Supplements – Mayo Clinic Proceedings
Perioperative Evaluation and Management of Endocrine Disorders – Mayo Clinic Proceedings
Preoperative Cardiac Risk Assessment – Mayo Clinic Proceedings
Preoperative Evaluation Before Noncardiac Surgery – Mayo Clinic Proceedings
Perioperative Cardiac Risk Reduction in Noncardiac Surgery – Mayo Clinic Proceedings
Perioperative Venous Thromboembolism Prophylaxis – Mayo Clinic Proceedings
FDA authorizes updated COVID boosters from Moderna and Pfizer.
5 Sep, 2022 | 14:36h | UTCFDA authorizes updated COVID boosters from Moderna and Pfizer – CIDRAP
FDA News Release: Coronavirus (COVID-19) Update: FDA Authorizes Moderna, Pfizer-BioNTech Bivalent COVID-19 Vaccines for Use as a Booster Dose – U.S. Food & Drug Administration
Review | The prevention and treatment of nausea and vomiting during tumor therapy.
5 Sep, 2022 | 14:23h | UTCThe Prevention and Treatment of Nausea and Vomiting During Tumor Therapy – Deutsches Ärzteblatt International
Related:
SEOM clinical guideline emesis (2021) – Clinical and Translational Oncology
Prevention of Chemotherapy-Induced Nausea and Vomiting in the Older Patient: Optimizing Outcomes – Drugs & Aging (if the link is paywalled, try this one)
2022 ACC Expert Consensus | Role of nonstatin therapies for LDL-cholesterol lowering and managing cardiovascular disease risk.
2 Sep, 2022 | 13:17h | UTCNews Release: ACC Issues Guidance to Address New Nonstatin Therapies – American College of Cardiology
Commentary: New on the Scene Nonstatin Drugs: Experts Provide Guidance – TCTMD
Commentary on Twitter
📢 ACC releases Expert Consensus Decision Pathway on the Role of Nonstatin Therapies for LDL-Cholesterol Lowering in the Management of ASCVD Risk
Read more: https://t.co/WDOSPgQ1bx #ACCClinicalDoc pic.twitter.com/nt8S2pdBgD
— American College of Cardiology (@ACCinTouch) August 25, 2022
Review | Covid-19 vaccines — immunity, variants, boosters.
1 Sep, 2022 | 11:57h | UTCCovid-19 Vaccines — Immunity, Variants, Boosters – New England Journal of Medicine
Study Commentary | Zinc for the prevention or treatment of respiratory tract infections: a new systematic review.
1 Sep, 2022 | 11:46h | UTC
Study shows dentists should give antibiotics to high-risk patients to help prevent infectious endocarditis.
1 Sep, 2022 | 11:43h | UTCOriginal Study: Antibiotic Prophylaxis Against Infective Endocarditis Before Invasive Dental Procedures – Journal of the American College of Cardiology (link to abstract – $ for full-text)
Commentary: UK dentists should give antibiotics to patients at risk of heart infection – study – The Guardian
Review/Perspective | European hypertension guideline downgrading of beta-blockers is not justified.
31 Aug, 2022 | 11:51h | UTC
#ESCCongress | Effect of statin therapy on muscle symptoms: an individual participant data meta-analysis of large-scale, randomized, double-blind trials.
30 Aug, 2022 | 12:16h | UTCNews Release: Cardiovascular protection from statins greatly outweighs the risk of muscle symptoms – European Society of Cardiology
Commentary: Only Very Small Risk of Muscle Symptoms With Statins: CTT Collaboration – TCTMD
#ESCCongress – M-A | Patients with heart failure benefit from dapagliflozin regardless of ejection fraction.
30 Aug, 2022 | 12:14h | UTCNews Release: Patients with heart failure benefit from dapagliflozin regardless of ejection fraction – European Society of Cardiology
Related:
Case series of acute cholecystitis associated with the use of Glucagon-Like Peptide-1 Receptor agonists reported to the US Food and Drug Administration.
30 Aug, 2022 | 11:59h | UTCAcute Cholecystitis Associated With the Use of Glucagon-Like Peptide-1 Receptor Agonists Reported to the US Food and Drug Administration – JAMA Internal Medicine (free for a limited period)