Pharmacology/Pharmaceutical Industry | Links Medicus Content Curation & Alerts in Medicine

In hospital medication review can help to reduce readmission: updated @CochraneLibrary review summarises latest evidence https://t.co/mrbIZRBs8b Let's look beyond headline & consider applicability….

— Toby Lasserson (@tlassers) January 23, 2023

FDA no longer needs to require animal tests before human drug trials

24 Jan, 2023 | 14:32h | UTC

FDA no longer needs to require animal tests before human drug trials – Science

AHA Statement | Cancer therapy-related hypertension

23 Jan, 2023 | 13:46h | UTC

Cancer Therapy–Related Hypertension: A Scientific Statement From the American Heart Association – Hypertension

Top Things to Know: Cancer Therapy-Related HTN – American Heart Association

Commentary: Cancer and hypertension induced by anticancer drugs: The need for increased awareness, improved detection and proactive management – American Heart Association

Prescribing cascades: how to detect them, prevent them, and use them appropriately

23 Jan, 2023 | 13:41h | UTC

Prescribing Cascades: How to Detect Them, Prevent Them, and Use Them Appropriately – Deutsches Ärzteblatt international

Prescribing cascades in community-dwelling adults: A systematic review – Pharmacologic Research & Perspectives

Evidence of a gabapentinoid and diuretic prescribing cascade among older adults with lower back pain – Journal of the American Geriatrics Society (link to abstract – $ for full-text)

Are you the victim of a prescribing cascade?

Study: Evaluation of a Common Prescribing Cascade of Calcium Channel Blockers and Diuretics in Older Adults with Hypertension

Prescribing Cascade in a Cardiology Practice

Recurrent venous thromboembolism and bleeding with extended anticoagulation: the VTE-PREDICT risk score

18 Jan, 2023 | 14:37h | UTC

Recurrent venous thromboembolism and bleeding with extended anticoagulation: the VTE-PREDICT risk score – European Heart Journal

See calculator: https://vtepredict.com/

Commentary on Twitter

The effect of extended anticoagulant treatment for individual patients with venous thromboembolism: the results from the VTE-PREDICT risk score! #venous #thromboembolism #anticoagulant #bleeding #score #EHJ #cardiotwitter @ESC_Journals @escardio
https://t.co/u3NHWyB9rv pic.twitter.com/ifOFxaXV1I

— EHJ Editor-in-Chief (@ehj_ed) January 17, 2023

Cohort Study | Proton pump inhibitors are unlikely to be major teratogens during pregnancy

18 Jan, 2023 | 14:14h | UTC

Association Between Proton Pump Inhibitor Use During Early Pregnancy and Risk of Congenital Malformations – JAMA Network Open

Commentary on Twitter

This large nationwide cohort study of 2.7 million pregnancies suggested that maternal proton pump inhibitor use during pregnancy is not associated with an increased risk of congenital malformations. https://t.co/fvgthhIYa7

— JAMA Network Open (@JAMANetworkOpen) January 10, 2023

Cohort Study | Safety and effects of buprenorphine-naloxone, buprenorphine, and methadone throughout pregnancy in maternal opioid use disorder

18 Jan, 2023 | 14:10h | UTC

Buprenorphine-naloxone, buprenorphine, and methadone throughout pregnancy in maternal opioid use disorder – Acta Obstetricia et Gynecologica Scandinavica

Commentary: Buprenorphine-Naloxone Appears Safe for Maternal Opioid Use Disorder – HealthDay

Cohort Study | Antibiotic exposure linked to increased risk of inflammatory bowel disease

13 Jan, 2023 | 13:25h | UTC

Antibiotic use as a risk factor for inflammatory bowel disease across the ages: a population-based cohort study – Gut

News Release: Frequent use of antibiotics may heighten inflammatory bowel disease risk in over 40s – BMJ Newsroom

Commentaries:

Antibiotics may increase risk of inflammatory bowel disease, study finds – CIDRAP

Antibiotic Exposure Positively Linked to IBD Development – HealthDay

Commentary on Twitter

#GUTPressRelease on the paper by @AdamFayeMD, @KristineAllin, @manasiagrawalmd, @PREDICTIBD et al

"Antibiotic use as a risk factor for inflammatory bowel disease across the ages: a population-based cohort study" viahttps://t.co/zc9bG3CpSm #GUTInTheNews pic.twitter.com/xra8wfEgnr

— Gut Journal (@Gut_BMJ) January 9, 2023

RCT | A 24-week, all-oral regimen for rifampin-resistant tuberculosis

12 Jan, 2023 | 13:27h | UTC

A 24-Week, All-Oral Regimen for Rifampin-Resistant Tuberculosis – New England Journal of Medicine

Commentary: Trial results show superiority of shorter, all-oral treatment for drug-resistant TB – CIDRAP

Circulating spike protein detected in post–COVID-19 mRNA vaccine myocarditis

11 Jan, 2023 | 14:30h | UTC

Circulating Spike Protein Detected in Post–COVID-19 mRNA Vaccine Myocarditis – Circulation

News Release: Researchers study immune response, proteins in blood of young adults who develop rare complication after COVID vaccination – Mass General Brigham

Commentary: Free spike proteins in the blood appear to play a role in myocarditis post-COVID mRNA vaccine – News Medical

RCT | Effect of prescriber notifications of patient’s fatal overdose on opioid prescribing at 4 to 12 months

10 Jan, 2023 | 14:50h | UTC

Effect of Prescriber Notifications of Patient’s Fatal Overdose on Opioid Prescribing at 4 to 12 Months: A Randomized Clinical Trial – JAMA Network Open

News Release: Study suggests one solution to America’s opioid epidemic: Tell doctors their patients fatally overdosed – University of Southern California

Commentary on Twitter

Letters notifying clinicians of a patient's fatal overdose reduced opioid prescribing up to one year after receiving the letter. https://t.co/cEU1inH9lE

— JAMA Network Open (@JAMANetworkOpen) January 6, 2023

Consensus Paper | Antipsychotic medication deprescribing among adult patients with critical illness

10 Jan, 2023 | 14:37h | UTC

A National Modified Delphi Consensus Process to Prioritize Experiences and Interventions for Antipsychotic Medication Deprescribing Among Adult Patients With Critical Illness – Critical Care Explorations

Commentary on Twitter

#CritCareExplore @SCCM Prescribing recommendations in ICU patients: limit antipsychotics to those with hyperactive delirium, at risk of harm to self/others or w/ care impacts. @n_jaworska@kiramakuk@KarlaKrewulak@dan_niven@lisa_burry@geetamehta0 @kmfiest https://t.co/73GUvrfJls pic.twitter.com/TbjbnGxD8Y

— Critical Care Explorations (@CritCareExplore) December 4, 2022

ACP Guideline | Pharmacologic treatment of primary osteoporosis or low bone mass to prevent fractures in adults

9 Jan, 2023 | 14:59h | UTC

Pharmacologic Treatment of Primary Osteoporosis or Low Bone Mass to Prevent Fractures in Adults: A Living Clinical Guideline From the American College of Physicians – Annals of Internal Medicine

News Release: American College of Physicians recommends bisphosphonates for initial treatment for osteoporosis in males and postmenopausal females diagnosed with primary osteoporosis

Summary for Patients: Pharmacologic Treatment of Primary Osteoporosis or Low Bone Mass to Prevent Fractures in Adults

WHO updates recommendations on HPV vaccination schedule

9 Jan, 2023 | 14:57h | UTC

News Release: WHO updates recommendations on HPV vaccination schedule – World Health Organization

Guideline: Human papillomavirus vaccines: WHO position paper, December 2022 – World Health Organization

Commentaries:

WHO Recommends One HPV Vaccine Dose Instead of Two; Move Should Help Expand Coverage – Health Policy Watch

WHO supports 1-dose HPV vaccine strategy – CIDRAP

Commentary on Twitter

🆕 WHO has revised its recommendations on possible schedules for human papillomavirus (#HPV) vaccines & now recommends:
👉1 or 2-doses for girls & women aged 9-20
👉2 doses with a 6-month interval for women 21+https://t.co/m0KZyH6sPR pic.twitter.com/W4PeS4raV9

— World Health Organization (WHO) (@WHO) December 21, 2022

Scientists tie third clinical trial death to experimental Alzheimer’s drug

9 Jan, 2023 | 14:47h | UTC

Scientists tie third clinical trial death to experimental Alzheimer’s drug – Science

RCT | The addition of Olanzapine to a triple antiemetic regimen effectively prevents nausea and vomiting during highly emetogenic chemotherapy.

16 Dec, 2022 | 13:32h | UTC

A multicenter, randomized, double-blind, placebo-controlled, phase 3 trial of olanzapine plus triple antiemetic regimen for the prevention of multiday highly emetogenic chemotherapy-induced nausea and vomiting (OFFER study) – eClinicalMedicine

RCT: Olanzapine may improve the control of vomiting in the delayed phase in children receiving highly emetogenic chemotherapy.

Randomized, open-label trial: Olanzapine seems effective for the prevention of vomiting in children and adolescents receiving highly emetogenic chemotherapy

Randomized Trial: Olanzapine Plus Standard Antiemetic Therapy for the Prevention of Chemotherapy-induced Nausea and Vomiting

Cohort Study | Assessment of depression and adherence to guideline-directed medical therapies following PCI.

14 Dec, 2022 | 14:59h | UTC

Assessment of Depression and Adherence to Guideline-Directed Medical Therapies Following Percutaneous Coronary Intervention – JAMA Network Open

Commentaries:

More Evidence of the Association of Depression With Adherence to Medical Therapies in Coronary Heart Disease – JAMA Network Open

Individuals with depression less likely to adhere to medications following percutaneous coronary intervention – News Medical / University of Pittsburg

Cohort Study | Association of in utero antipsychotic medication exposure with risk of congenital malformations.

8 Dec, 2022 | 13:00h | UTC

Association of In Utero Antipsychotic Medication Exposure With Risk of Congenital Malformations in Nordic Countries and the US – JAMA Psychiatry (free for a limited period)

Association of antipsychotic drug exposure in pregnancy with risk of neurodevelopmental disorders: a national birth cohort study.

Commentary on Twitter

New findings from a large cohort study including 26,000 antipsychotic-exposed pregnancies from 6 countries suggest that prenatal exposure to individual antipsychotics is generally not associated with an increase in risk of major congenital malformations https://t.co/4cUm8sXgsi

— JAMA Psychiatry (@JAMAPsych) December 7, 2022