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Pharmacology/Pharmaceutical Industry

Overuse of medications in low- and middle-income countries: a scoping review

27 Jan, 2023 | 12:31h | UTC

Overuse of medications in low- and middle-income countries: a scoping review – Bulletin of the World Health Organization

 


Perspective | Were bivalent boosters worth it? The biggest questions about the newest Covid-19 vaccines are still unanswered

27 Jan, 2023 | 12:19h | UTC

Were bivalent boosters worth it? The biggest questions about the newest Covid-19 vaccines are still unanswered – Vox

 


SR | Barriers and facilitators to deprescribing of cardiovascular medications

27 Jan, 2023 | 12:09h | UTC

Barriers and facilitators to deprescribing of cardiovascular medications: a systematic review – BMJ Open

Related:

Facing the challenge of polypharmacy when prescribing for older people with cardiovascular disease. A review by the European Society of Cardiology Working Group on Cardiovascular Pharmacotherapy – European Heart Journal – Cardiovascular Pharmacotherapy

Deprescribing in Older Adults with Cardiovascular Disease – Journal of the American College of Cardiology

Multimorbidity in Older Adults with Cardiovascular Disease – American College of Cardiology, Latest in Cardiology

 


Review | The blood–brain barrier and optimization of antibiotics for the treatment of CNS infections in adults

27 Jan, 2023 | 11:55h | UTC

The Blood–Brain Barrier and Pharmacokinetic/Pharmacodynamic Optimization of Antibiotics for the Treatment of Central Nervous System Infections in Adults – Antibiotics

 


Essential medicines for mental disorders: comparison of 121 national lists with WHO recommendations

26 Jan, 2023 | 12:55h | UTC

Essential medicines for mental disorders: comparison of 121 national lists with WHO recommendations – Archives of Public Health

 


SR | Medication review in hospitalized patients to reduce morbidity and mortality

24 Jan, 2023 | 14:37h | UTC

Medication review in hospitalised patients to reduce morbidity and mortality – Cochrane Library

Summary: What are the benefits and risks of medication reviews for hospitalized adults? – Cochrane Library

 

Commentary on Twitter (thread – click for more)

 


FDA no longer needs to require animal tests before human drug trials

24 Jan, 2023 | 14:32h | UTC

FDA no longer needs to require animal tests before human drug trials – Science

See also: The FDA no longer requires all drugs to be tested on animals before human trials – NPR

 


AHA Statement | Cancer therapy-related hypertension

23 Jan, 2023 | 13:46h | UTC

Cancer Therapy–Related Hypertension: A Scientific Statement From the American Heart Association – Hypertension

Top Things to Know: Cancer Therapy-Related HTN – American Heart Association

Commentary: Cancer and hypertension induced by anticancer drugs: The need for increased awareness, improved detection and proactive management – American Heart Association

 


Prescribing cascades: how to detect them, prevent them, and use them appropriately

23 Jan, 2023 | 13:41h | UTC

Prescribing Cascades: How to Detect Them, Prevent Them, and Use Them Appropriately – Deutsches Ärzteblatt international

Related:

Prescribing cascades in community-dwelling adults: A systematic review – Pharmacologic Research & Perspectives

Evidence of a gabapentinoid and diuretic prescribing cascade among older adults with lower back pain – Journal of the American Geriatrics Society (link to abstract – $ for full-text)

Are you the victim of a prescribing cascade?

Study: Evaluation of a Common Prescribing Cascade of Calcium Channel Blockers and Diuretics in Older Adults with Hypertension

Prescribing Cascade in a Cardiology Practice

 


Recurrent venous thromboembolism and bleeding with extended anticoagulation: the VTE-PREDICT risk score

18 Jan, 2023 | 14:37h | UTC

Recurrent venous thromboembolism and bleeding with extended anticoagulation: the VTE-PREDICT risk score – European Heart Journal

See calculator: https://vtepredict.com/

 

Commentary on Twitter

 


Cohort Study | Proton pump inhibitors are unlikely to be major teratogens during pregnancy

18 Jan, 2023 | 14:14h | UTC

Association Between Proton Pump Inhibitor Use During Early Pregnancy and Risk of Congenital Malformations – JAMA Network Open

 

Commentary on Twitter

 


Cohort Study | Safety and effects of buprenorphine-naloxone, buprenorphine, and methadone throughout pregnancy in maternal opioid use disorder

18 Jan, 2023 | 14:10h | UTC

Buprenorphine-naloxone, buprenorphine, and methadone throughout pregnancy in maternal opioid use disorder – Acta Obstetricia et Gynecologica Scandinavica

Commentary: Buprenorphine-Naloxone Appears Safe for Maternal Opioid Use Disorder – HealthDay

 


Cohort Study | Antibiotic exposure linked to increased risk of inflammatory bowel disease

13 Jan, 2023 | 13:25h | UTC

Antibiotic use as a risk factor for inflammatory bowel disease across the ages: a population-based cohort study – Gut

News Release: Frequent use of antibiotics may heighten inflammatory bowel disease risk in over 40s – BMJ Newsroom

Commentaries: 

Antibiotics may increase risk of inflammatory bowel disease, study finds – CIDRAP

Antibiotic Exposure Positively Linked to IBD Development – HealthDay

 

Commentary on Twitter

 


RCT | A 24-week, all-oral regimen for rifampin-resistant tuberculosis

12 Jan, 2023 | 13:27h | UTC

A 24-Week, All-Oral Regimen for Rifampin-Resistant Tuberculosis – New England Journal of Medicine

Commentary: Trial results show superiority of shorter, all-oral treatment for drug-resistant TB – CIDRAP

 


Circulating spike protein detected in post–COVID-19 mRNA vaccine myocarditis

11 Jan, 2023 | 14:30h | UTC

Circulating Spike Protein Detected in Post–COVID-19 mRNA Vaccine Myocarditis – Circulation

News Release: Researchers study immune response, proteins in blood of young adults who develop rare complication after COVID vaccination – Mass General Brigham

Commentary: Free spike proteins in the blood appear to play a role in myocarditis post-COVID mRNA vaccine – News Medical

 


RCT | Effect of prescriber notifications of patient’s fatal overdose on opioid prescribing at 4 to 12 months

10 Jan, 2023 | 14:50h | UTC

Effect of Prescriber Notifications of Patient’s Fatal Overdose on Opioid Prescribing at 4 to 12 Months: A Randomized Clinical Trial – JAMA Network Open

News Release: Study suggests one solution to America’s opioid epidemic: Tell doctors their patients fatally overdosed – University of Southern California

 

Commentary on Twitter

 


Consensus Paper | Antipsychotic medication deprescribing among adult patients with critical illness

10 Jan, 2023 | 14:37h | UTC

A National Modified Delphi Consensus Process to Prioritize Experiences and Interventions for Antipsychotic Medication Deprescribing Among Adult Patients With Critical Illness – Critical Care Explorations

 

Commentary on Twitter

 


ACP Guideline | Pharmacologic treatment of primary osteoporosis or low bone mass to prevent fractures in adults

9 Jan, 2023 | 14:59h | UTC

Pharmacologic Treatment of Primary Osteoporosis or Low Bone Mass to Prevent Fractures in Adults: A Living Clinical Guideline From the American College of Physicians – Annals of Internal Medicine

See also: Effectiveness and Safety of Treatments to Prevent Fractures in People With Low Bone Mass or Primary Osteoporosis: A Living Systematic Review and Network Meta-analysis for the American College of Physicians – Annals of Internal Medicine

News Release: American College of Physicians recommends bisphosphonates for initial treatment for osteoporosis in males and postmenopausal females diagnosed with primary osteoporosis

Summary for Patients: Pharmacologic Treatment of Primary Osteoporosis or Low Bone Mass to Prevent Fractures in Adults

 


WHO updates recommendations on HPV vaccination schedule

9 Jan, 2023 | 14:57h | UTC

News Release: WHO updates recommendations on HPV vaccination schedule – World Health Organization

Guideline: Human papillomavirus vaccines: WHO position paper, December 2022 – World Health Organization

Commentaries: 

WHO Recommends One HPV Vaccine Dose Instead of Two; Move Should Help Expand Coverage – Health Policy Watch

WHO supports 1-dose HPV vaccine strategy – CIDRAP

 

Commentary on Twitter

 


Scientists tie third clinical trial death to experimental Alzheimer’s drug

9 Jan, 2023 | 14:47h | UTC

Scientists tie third clinical trial death to experimental Alzheimer’s drug – Science

Related: RCT | Lecanemab slows cognitive decline in early Alzheimer’s disease but raises safety concerns.

 


RCT | The addition of Olanzapine to a triple antiemetic regimen effectively prevents nausea and vomiting during highly emetogenic chemotherapy.

16 Dec, 2022 | 13:32h | UTC

A multicenter, randomized, double-blind, placebo-controlled, phase 3 trial of olanzapine plus triple antiemetic regimen for the prevention of multiday highly emetogenic chemotherapy-induced nausea and vomiting (OFFER study) – eClinicalMedicine

Related:

RCT: Olanzapine may improve the control of vomiting in the delayed phase in children receiving highly emetogenic chemotherapy.

Randomized, open-label trial: Olanzapine seems effective for the prevention of vomiting in children and adolescents receiving highly emetogenic chemotherapy

Randomized Trial: Olanzapine Plus Standard Antiemetic Therapy for the Prevention of Chemotherapy-induced Nausea and Vomiting

 


Cohort Study | Assessment of depression and adherence to guideline-directed medical therapies following PCI.

14 Dec, 2022 | 14:59h | UTC

Assessment of Depression and Adherence to Guideline-Directed Medical Therapies Following Percutaneous Coronary Intervention – JAMA Network Open

Commentaries: 

More Evidence of the Association of Depression With Adherence to Medical Therapies in Coronary Heart Disease – JAMA Network Open

Individuals with depression less likely to adhere to medications following percutaneous coronary intervention – News Medical / University of Pittsburg 

 


Cohort Study | Association of in utero antipsychotic medication exposure with risk of congenital malformations.

8 Dec, 2022 | 13:00h | UTC

Association of In Utero Antipsychotic Medication Exposure With Risk of Congenital Malformations in Nordic Countries and the US – JAMA Psychiatry (free for a limited period)

Related:

Association of antipsychotic drug exposure in pregnancy with risk of neurodevelopmental disorders: a national birth cohort study.

 

Commentary on Twitter

 


ASCO Guideline | Use of opioids for adults with pain from cancer or cancer treatment.

7 Dec, 2022 | 14:32h | UTC

Use of Opioids for Adults With Pain From Cancer or Cancer Treatment: ASCO Guideline – Journal of Clinical Oncology

 


Case Report | Vitamin D intoxication and severe hypercalcemia complicating nutritional supplements misuse.

6 Dec, 2022 | 13:56h | UTC

Vitamin D intoxication and severe hypercalcaemia complicating nutritional supplements misuse – BMJ Case Reports

Commentaries:

Vitamin D supplement ‘overdosing’ is possible and harmful, warn doctors – Medical Dialogues

How an increasingly popular supplement landed a man in the hospital – CNN

You Can Take Too Much Vitamin D — One Man Found Out the Hard Way – HealthDay

 


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