Pharmacology
Observational Study Suggests an Increased Risk of COVID-19 Among Users of Proton Pump Inhibitors
10 Jul, 2020 | 09:19h | UTCCommentaries: Increased Risk of COVID-19 Among Users of Proton Pump Inhibitors (PPIs) – American College of Gastroenterology AND Popular Heartburn Drugs Linked to Heightened COVID-19 Risk – TIME
[Abstract Only] Randomized Trial: Baloxavir Marboxil for Prophylaxis against Influenza in Household Contacts
9 Jul, 2020 | 09:22h | UTCCommentary: Baloxavir Helps Prevent Flu in Exposed Household Contacts – NEJM Journal Watch
Randomized Trial: Probiotic Use Does Not Reduce Antibiotic Administration Among Care Home Residents
9 Jul, 2020 | 09:20h | UTCCommentary: Probiotics do not reduce antibiotic prescribing in care home residents, shows study – University of Oxford
Related Commentary on Twitter
There is no evidence that #probiotics reduce antibiotic administration for acute infections in care home residents, finds PRINCESS Trial published today in @JAMA_current#carehomes
➡️https://t.co/7yEpKA3rp9 pic.twitter.com/xnthh0bLWK
— OxPrimaryCareSci (@OxPrimaryCare) July 7, 2020
Methotrexate is Not an Additional Risk Factor for Interstitial Lung Disease in RA Patients
8 Jul, 2020 | 00:54h | UTCRelated Review: Treatment of Rheumatoid Arthritis-Associated Interstitial Lung Disease: Lights and Shadows – Journal of Clinical Medicine
Meta-Analysis: Comparative Effectiveness of Biological Medicines in Rheumatoid Arthritis
8 Jul, 2020 | 00:53h | UTCCommentary: Lessons from a network meta-analysis of biologics in rheumatoid arthritis – The BMJ Opinion
Data Show Panic and Disorganization Dominate the Study of Covid-19 Drugs
7 Jul, 2020 | 09:02h | UTCData show panic and disorganization dominate the study of Covid-19 drugs – STAT
Related: Waste in covid-19 research – The BMJ AND Too much information, too little evidence: is waste in research fuelling the covid-19 infodemic? – The BMJ AND Urgent call for greater multilateralism and coordination of covid-19 trials – The BMJ
WHO: Access to HIV Medicines Severely Impacted by COVID-19 as AIDS Response Stalls
7 Jul, 2020 | 09:01h | UTCCommentary: Pandemic tops 11.5 million cases, imperils HIV care – CIDRAP
Developing a SARS-CoV-2 Vaccine at Warp Speed
7 Jul, 2020 | 08:59h | UTCDeveloping a SARS-CoV-2 Vaccine at Warp Speed – JAMA
Related Video: Coronavirus Vaccine Development – JAMA
Podcast: A Clinical Pharmacologist’s Perspective on Penicillin Allergy
7 Jul, 2020 | 08:43h | UTCA Clinical Pharmacologist’s Perspective on Penicillin Allergy – JAMA
ACMT Position Statement: Medication Administration and Safety During the Response to COVID-19 Pandemic
6 Jul, 2020 | 09:04h | UTC
WHO Discontinues Hydroxychloroquine and Lopinavir/Ritonavir Treatment Arms for COVID-19
6 Jul, 2020 | 09:02h | UTCCommentary: WHO says trials show malaria and HIV drugs don’t cut Covid-19 hospital deaths – The Guardian
Related Commentary on Twitter
WHO accepted the recommendation from the Solidarity Trial’s International Steering Committee to discontinue the trial’s hydroxychloroquine and the lopinavir/ritonavir arms.
More https://t.co/dCxHqBIwtr#COVID19 #coronavirus
— World Health Organization (WHO) (@WHO) July 4, 2020
Study Publications Must Be Up-To-Date in Covid Time (Regarding the Latest Observational Hydroxychloroquine Study)
6 Jul, 2020 | 09:00h | UTCStudy Publications Must Be Up-To-Date in Covid Time – Absolutely Maybe Blog, by Hilda Bastian
Opinion – One U.K. Trial is Transforming COVID-19 Treatment. Why Haven’t Others Delivered More Results?
6 Jul, 2020 | 08:58h | UTCStudy 1 – lopinavir-ritonavir: No clinical benefit from use of lopinavir-ritonavir in hospitalised COVID-19 patients studied in RECOVERY
Study 2 – dexamethasone: Low-cost dexamethasone reduces death by up to one third in hospitalised patients with severe respiratory complications of COVID-19 – Recovery Trial AND Effect of Dexamethasone in Hospitalized Patients with COVID-19: Preliminary Report – medRxiv
Study 3 – hydroxychloroquine: No clinical benefit from use of hydroxychloroquine in hospitalised patients with COVID-19
Meta-analysis: The Safety and Efficacy of Aspirin Discontinuation on a Background of a P2Y12 Inhibitor in Patients after Percutaneous Coronary Intervention
6 Jul, 2020 | 08:27h | UTCCommentaries: Short DAPT Reduces Bleeding With No Increase in MACE: Meta-analysis – TCTMD AND Discontinuing Aspirin on Background of P2Y12 Inhibitor After PCI – American College of Cardiology
Accelerating Development of SARS-CoV-2 Vaccines — The Role for Controlled Human Infection Models
2 Jul, 2020 | 08:49h | UTCRelated: Challenge Trials—Could Deliberate Coronavirus Exposure Hasten Vaccine Development? – JAMA AND Opinion: Ethical Guidelines for Deliberately Infecting Volunteers with COVID-19 to Speed Vaccine Development (commentaries on the subject) AND Feasibility, potential value and limitations of establishing a closely monitored challenge model of experimental COVID-19 infection and illness in healthy young adult volunteers – World Health Organization (draft document for public comments) AND Human Challenge Studies to Accelerate Coronavirus Vaccine Licensure – The Journal of Infectious Diseases AND Ethics of controlled human infection to address COVID-19 – Science AND Extraordinary diseases require extraordinary solutions – Vaccine
Opinion: The Moral Imperative to Include Pregnant Women in Clinical Trials of Interventions for COVID-19
2 Jul, 2020 | 08:46h | UTC
Evidence Does Not Support Vitamin D for Reducing Respiratory Infections, Reviews Conclude
2 Jul, 2020 | 08:42h | UTCEvidence does not support vitamin D for reducing respiratory infections, reviews conclude – The BMJ
Randomized Trial: Amoxicillin for 3 Days Noninferior to Amoxicillin for 5 Days for Chest-Indrawing Pneumonia in Children
2 Jul, 2020 | 08:41h | UTCVisual Abstract: Amoxicillin for 3 or 5 Days for Chest-Indrawing Pneumonia
Commentaries: Antibiotic use, duration questioned for kids’ pneumonia in low-resource areas – CIDRAP AND Three-day amoxicillin course effective for chest-indrawing pneumonia in Malawi children – 2 Minute Medicine
Randomized Trial of Amoxicillin vs. Placebo for Pneumonia in Children from Low-Income Communities
2 Jul, 2020 | 08:40h | UTCRandomized Trial of Amoxicillin for Pneumonia in Pakistan – New England Journal of Medicine
[Abstract Only] Randomized Trial: Triple Inhaled Therapy at Two Glucocorticoid Doses in Moderate-to-Very-Severe COPD
2 Jul, 2020 | 08:39h | UTCCommentaries: Triple Therapy at 2 Doses Appears to Reduce COPD Exacerbations, Study Says – AJMC AND Triple Inhaled Therapy Aids in Moderate-to-Very Severe COPD – Physician’s Weekly
[Abstract Only] Randomized Trial: Early Vaginal Progesterone in Twin Pregnancies Does Not Prevent Spontaneous Preterm Birth
2 Jul, 2020 | 08:36h | UTCEarly vaginal progesterone versus Placebo in Twin Pregnancies for prevention of spontaneous preterm birth (EVENTS): A randomised double-blind trial – American Journal of Obstetrics & Gynecology (link to abstract – $ for full-text)
Related Studies: Randomized Trial: Progesterone in Women with Bleeding in Early Pregnancy (link to study and commentaries) AND Randomized Trial: Injectable 17-α-hydroxyprogesterone Not Effective for the Prevention of Recurrent Preterm Birth (link to study and commentaries)
Systematic Review: Systemic Defenses to Prevent Intravenous Medication Errors in Hospitals
2 Jul, 2020 | 08:32h | UTCCommentary: Systemic defenses to prevent intravenous medication errors in hospitals: a systematic review – PSNet
[Abstract Only] Meta-analysis: Comparative Effectiveness of Glucose-Lowering Drugs for Type 2 Diabetes
1 Jul, 2020 | 07:28h | UTCComparative Effectiveness of Glucose-Lowering Drugs for Type 2 Diabetes: A Systematic Review and Network Meta-analysis – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: Meta-Analysis Aims to Compare Antidiabetic Medications in T2D Population – AJMC AND Metformin-based therapy should be first-line treatment for patients with type 2 diabetes at low cardiovascular risk – American College of Physicians
Press Release: No Clinical Benefit from Use of Lopinavir-ritonavir in Hospitalized COVID-19 Patients
30 Jun, 2020 | 08:08h | UTC
NICE Evidence Summary: Vitamin D Not Indicated to Prevent or Treat COVID-19
30 Jun, 2020 | 07:56h | UTC