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J&J COVID-19 Vaccine: FDA recommends booster shot for all adults aged 18 and older at least two months following initial vaccination with the single-shot vaccine.

17 Oct, 2021 | 21:32h | UTC

News release: Johnson & Johnson COVID-19 Vaccine Booster Shot Unanimously Recommended for Emergency Use Authorization by U.S. FDA Advisory Committee

Commentaries:

FDA panel endorses booster shot for J&J COVID-19 vaccine – Associated Press

The Johnson & Johnson one-dose vaccine offers good protection now. A booster shot will maximize that, experts say – CNN

FDA advisers recommend J&J Covid-19 vaccine boosters, talk mix and match boosters – CNN

Related: [Press release – not published yet] J&J says booster shot at two months provided 75% protection against moderate to severe COVID-19 globally and 94% of such cases in the U.S.

 


[Preprint] Breakthrough SARS-CoV-2 infections in 620,000 U.S. Veterans, February 1, 2021 to August 13, 2021 – “Vaccine protection declined by mid-August 2021, decreasing from 91.9% in March to 53.9%”.

17 Oct, 2021 | 21:29h | UTC

Breakthrough SARS-CoV-2 infections in 620,000 U.S. Veterans, February 1, 2021 to August 13, 2021 – medRxiv

Related:

Observational study in Qatar showed the effectiveness of Pfizer vaccine against any SARS-CoV-2 infection dropped to 20% in months 5 through 7 after the second dose, but effectiveness against severe Covid-19 remained high.

Cohort study: Pfizer vaccine effectiveness against any infections declined from 88% during the first month after full vaccination to 47% after 5 months. Vaccine effectiveness against hospital admissions remained high; 87% within 1 month, and 88% at 5 months after full vaccination, with no significant waning.

Editorial | Covid-19 vaccination: evidence of waning immunity is overstated.

COVID vaccine immunity is waning — how much does that matter? – “As debates about booster shots heat up, what’s known about the duration of vaccine-based immunity is still evolving”.

COVID vaccine effects wane over time but still prevent death and severe illness.

Perspective | What we actually know about waning immunity.

Another study shows Pfizer mRNA vaccine immunity is reduced over time.

[Press release – not published yet] Study shows vaccine protection wanes over time, but vaccines still offer good protection against severe disease.

Studies: COVID vaccine protection waning against infection but not hospitalization.

 

Commentary on Twitter

 


What can masks do? Part 2: What makes for a good mask study — and why most fail.

17 Oct, 2021 | 21:25h | UTC

COMMENTARY: What can masks do? Part 2: What makes for a good mask study — and why most fail – CIDRAP

See also: COMMENTARY: What can masks do? Part 1: The science behind COVID-19 protection – CIDRAP

 


PHE Statement: The role of face coverings in mitigating the transmission of SARS-CoV-2 virus.

15 Oct, 2021 | 02:52h | UTC

The role of face coverings in mitigating the transmission of SARS-CoV-2 virus: statement from the Respiratory Evidence Panel – Public Health England

 

Commentary on Twitter

 


What can masks do? The science behind COVID-19 protection.

15 Oct, 2021 | 02:51h | UTC

COMMENTARY: What can masks do? Part 1: The science behind COVID-19 protection – CIDRAP

 


Study evaluated several heterologous SARS-CoV-2 vaccine regimens; no efficacy data but there was increased antibody production on study days 15 and 29 after booster shots from Moderna and Pfizer.

15 Oct, 2021 | 02:49h | UTC

Heterologous SARS-CoV-2 Booster Vaccinations: Preliminary Report – medRxiv

Commentary: Study: Mixing and Matching COVID-19 Booster Shots Is Effective, Safe – U.S. News

 

Commentary on Twitter

 


‘I hope you die’: how the COVID pandemic unleashed attacks on scientists.

15 Oct, 2021 | 02:46h | UTC

‘I hope you die’: how the COVID pandemic unleashed attacks on scientists – Nature

 

Commentary on Twitter

 


Perspective | Trying to Block SARS-CoV-2 Transmission With Intranasal Vaccines.

15 Oct, 2021 | 02:44h | UTC

Trying to Block SARS-CoV-2 Transmission With Intranasal Vaccines – JAMA

 


FDA panel green-lights Moderna COVID boosters for risk groups.

15 Oct, 2021 | 02:43h | UTC

FDA panel green-lights Moderna COVID boosters for risk groups – CIDRAP

 


Editorial: Covid-19 treatments and vaccines must be evaluated in pregnancy.

15 Oct, 2021 | 02:41h | UTC

Covid-19 treatments and vaccines must be evaluated in pregnancy – The BMJ

Related:

Two observational studies suggest spontaneous abortion is not increased following COVID-19 mRNA vaccination during pregnancy.

Study shows high effectiveness of the Pfizer mRNA COVID-19 vaccine in pregnancy.

5 Crucial Things to Know About COVID-19 Vaccines and Pregnancy.

CDC Guidance: Pregnant people should be vaccinated against COVID-19.

ACOG and SMFM Recommend COVID-19 Vaccination for Pregnant Individuals – “ACOG encourages its members to enthusiastically recommend vaccination to their patients.”

Cohort study: Pfizer/BioNTech COVID vaccine associated with 78% lower risk of Covid-19 in pregnancy.

 

Commentary on Twitter

 


Cohort study: Vaccinated pregnant patients had 90% lower risk of severe or critical Covid-19 compared with unvaccinated pregnant patients.

15 Oct, 2021 | 02:38h | UTC

Maternal Outcomes After Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection in Vaccinated Compared With Unvaccinated Pregnant Patients – Obstetrics & Gynecology

Related:

Two observational studies suggest spontaneous abortion is not increased following COVID-19 mRNA vaccination during pregnancy.

Study shows high effectiveness of the Pfizer mRNA COVID-19 vaccine in pregnancy.

5 Crucial Things to Know About COVID-19 Vaccines and Pregnancy.

CDC Guidance: Pregnant people should be vaccinated against COVID-19.

ACOG and SMFM Recommend COVID-19 Vaccination for Pregnant Individuals – “ACOG encourages its members to enthusiastically recommend vaccination to their patients.”

Cohort study: Pfizer/BioNTech COVID vaccine associated with 78% lower risk of Covid-19 in pregnancy.

 

Commentary on Twitter (thread – click for more)

 


WHO Report: Tuberculosis deaths rise for the first time in more than a decade due to the COVID-19 pandemic.

15 Oct, 2021 | 02:30h | UTC

Tuberculosis deaths rise for the first time in more than a decade due to the COVID-19 pandemic – World Health Organization

Report: Global tuberculosis report 2021

Commentary: Tuberculosis deaths rise for 1st time in years, due to COVID – Associated Press

 

Commentary on Twitter (thread – click for more)

 


FDA issues food industry guidance for reduction of sodium in processed and packaged foods.

15 Oct, 2021 | 02:29h | UTC

News Release: To Improve Nutrition and Reduce the Burden of Disease, FDA Issues Food Industry Guidance for Voluntarily Reducing Sodium in Processed and Packaged Foods – U.S. Food & Drug Administration

Guidance for Industry: Voluntary Sodium Reduction Goals – U.S. Food & Drug Administration

Commentaries:

FDA Issues New Guidance on Sodium Targets for Food Industry – TCTMD

Reducing Sodium Intake in the US: Healthier Lives, Healthier Future – JAMA

FDA Reduces Recommended Salt Levels in Americans’ Food – HealthDay

FDA guidance to food industry aims to reduce sodium consumption – American Heart Association

New FDA guidance aims to drastically cut salt in food supply – NBC News

 


Former CDC director: Low sodium salt could save millions of lives.

15 Oct, 2021 | 02:27h | UTC

Former CDC director: Low sodium salt could save millions of lives – CNN

Related:

Is salt good for you after all? The evidence says no.

#ESCCongress – Cluster RCT: Among patients at increased risk for stroke, salt substitution (75% sodium chloride and 25% potassium chloride by mass) reduced the rates of stroke, major cardiovascular events, and death from any cause.

Systematic Review: Altered dietary salt intake for people with chronic kidney disease.

New WHO benchmarks help countries reduce salt intake and save lives.

RCT: Reduced-sodium added-potassium salt substitute reduces blood pressure in hypertensive patients

Potassium Enriched Salt Substitution Could Prevent a Large Number of Cardiovascular Deaths

Meta-Analysis: Effect of Reduction in Dietary Sodium on Blood Pressure Levels

Cluster Randomized Trial: Effect of Salt Substitution on Community-wide Blood Pressure and Hypertension Incidence

 


[Preprint] In RCT with 29,949 participants, the Novavax vaccine demonstrated high overall efficacy (>90%) for the prevention of Covid-19, and all moderate-to-severe cases occurred in placebo recipients.

14 Oct, 2021 | 10:17h | UTC

Efficacy and Safety of NVX-CoV2373 in Adults in the United States and Mexico – medRxiv

Commentary: Novel vaccine demonstrates high efficacy for prevention of COVID-19 – News Medical

Related:

RCT: Novavax vaccine conferred 89.7% protection against symptomatic SARS-CoV-2 infection and 100% protection against hospitalizations or deaths.

Opinion | The mRNA vaccines are extraordinary, but Novavax is even better.

(Press release – not published yet) Novavax COVID-19 vaccine demonstrates 90% overall efficacy and 100% protection against moderate and severe disease.

RCT: Novavax vaccine is 49.4% effective against B.1.351 SARS-CoV-2 variant.

[Press release – not published yet] Novavax reports 96% efficacy against original strain of COVID-19, 86% efficacy against B.1.1.7 variant, and 55% efficacy against B1.351 variant

New COVID-19 vaccines: here’s how the promising Novavax and Johnson & Johnson jabs work

Covid-19: Novavax vaccine efficacy is 86% against UK variant and 60% against South African variant

 

Commentary on Twitter

 


Systematic Review: Short-term and long-term rates of postacute sequelae of SARS-CoV-2 infection.

14 Oct, 2021 | 10:15h | UTC

Short-term and Long-term Rates of Postacute Sequelae of SARS-CoV-2 Infection: A Systematic Review – JAMA Network Open

Commentaries:

Most COVID-19 survivors have symptoms 6 months on, review finds – CIDRAP

Expert reaction to systematic review on rates of postacute sequelae of SARS-CoV-2 infection (PASC) – Science Media Centre

How many people get ‘long COVID’? More than half, researchers find – Penn State

Related:

WHO Consensus: A clinical case definition of post COVID-19 condition (Long Covid).

Characterizing long COVID: a living systematic review.

Long Covid – The illness narratives.

New guidelines to help doctors manage long COVID patients published.

M-A: More than 50 long-term effects of COVID-19. (several articles on the subject)

 

Commentary on Twitter

 


How Covax failed on its promise to vaccinate the world – “Covax, described as “naively ambitious” by one expert, has contributed just 5% of all vaccines administered globally”.

14 Oct, 2021 | 10:12h | UTC

How Covax failed on its promise to vaccinate the world – The Bureau of Investigative Journalism

Related:

Perspective | A beautiful idea: how COVAX has fallen short.

WHO Launches Strategy to Achieve Global Covid-19 Vaccination by mid-2022.

WHO special envoys: To beat Covid, there’s a simple lesson – no one’s safe until everyone’s safe.

Joint COVAX Statement on the Equal Recognition of Vaccines – COVAX urges all government authorities to recognize as fully vaccinated all people who have received COVID-19 vaccines that have been deemed safe and effective by WHO.

WHO COVAX Joint Statement: Call to action to equip COVAX to deliver 2 billion doses in 2021.

Covax: How will Covid vaccines be shared around the world?

 


WHO provides guidance to address the shortage of quality palliative care services.

14 Oct, 2021 | 09:59h | UTC

News release: WHO takes steps to address glaring shortage of quality palliative care services – World Health Organization

See Guidance:

Assessing the development of palliative care worldwide: a set of actionable indicators – World Health Organization

Quality health services and palliative care: practical approaches and resources to support policy, strategy and practice – World Health Organization

 

Commentary on Twitter (thread – click for more)

 


WHO advisers recommend 3rd COVID vaccine dose for highest-risk groups.

13 Oct, 2021 | 01:48h | UTC

WHO advisers recommend 3rd COVID vaccine dose for highest-risk groups – CIDRAP

See also: WHO advises additional COVID shot for immunocompromised people – Reuters

 


Opinion | COVID lesson: trust the public with hard truths.

13 Oct, 2021 | 01:47h | UTC

COVID lesson: trust the public with hard truths – Nature

 

Commentary from the author on Twitter (thread – click for more)

 


A primer on what we know about mixing and matching Covid vaccines.

13 Oct, 2021 | 01:44h | UTC

A primer on what we know about mixing and matching Covid vaccines – STAT

Related:

Real-world data shows increased reactogenicity in adults after heterologous compared to homologous prime-boost COVID-19 vaccination.

RCT: Safety and immunogenicity of heterologous vs. homologous prime-boost schedules with an adenoviral vectored and mRNA COVID-19 vaccine.

Another study shows increased immune response with heterologous Oxford-AstraZeneca/mRNA vaccination.

Heterologous Oxford–AstraZeneca and Moderna Vaccination induce increased levels of neutralizing antibody compared to 2 doses of Oxford–AstraZeneca.

Heterologous Oxford–AstraZeneca and BioNTech/Pfizer Vaccination induce increased levels of neutralizing antibody compared to 2 doses of Oxford–AstraZeneca.

[Preprint] Mixing Covid jabs has good immune response, study finds – “The Com-Cov trial looked at the efficacy of either two doses of Pfizer, two of AstraZeneca, or one of them followed by the other. All combinations worked well, priming the immune system”.

Phase 2 RCT: Immunogenicity and reactogenicity of a Pfizer-BioNTech booster in patients that have received a single dose of AstraZeneca vaccine – “BNT162b2 (Pfizer) given as a second dose in individuals prime vaccinated with ChAdOx1-S (AstraZeneca) induced a robust immune response, with an acceptable and manageable reactogenicity profile”.

Lab study shows heterologous AstraZeneca/Pfizer vaccination produces strong immune response against SARS-CoV-2 Delta variant.

Lab study shows a heterologous AstraZeneca + Pfizer immunization strategy provides stronger immunogenicity against Covid compared to homologous AZ + AZ or Pfizer + Pfizer strategies.

RCT: Mixing 2 different Covid vaccines is associated with increased risk of side effects.

 


Real-world data show that filters clean COVID-causing virus from air.

13 Oct, 2021 | 01:43h | UTC

Real-world data show that filters clean COVID-causing virus from air – Nature

Original article: The removal of airborne SARS-CoV-2 and other microbial bioaerosols by air filtration on COVID-19 surge units – medRxiv

 

Commentary on Twitter

 


Seroconversion and fever are dose-dependent in a nonhuman primate model of inhalational COVID-19.

13 Oct, 2021 | 01:41h | UTC

Seroconversion and fever are dose-dependent in a nonhuman primate model of inhalational COVID-19 – PLOS Pathogens

Commentary: Dose-dependent COVID-19 symptoms – Nature Reviews Microbiology

 

Commentaries on Twitter

 


Review: Optimal diet for cardiovascular and planetary health.

13 Oct, 2021 | 01:22h | UTC

Optimal diet for cardiovascular and planetary health – Heart

 


Anemia prevalence in women of reproductive age in low- and middle-income countries between 2000 and 2018.

13 Oct, 2021 | 01:21h | UTC

Anemia prevalence in women of reproductive age in low- and middle-income countries between 2000 and 2018 – Nature Medicine

Invited commentary: Anemia in women — an intractable problem that requires innovative solutions – Nature Medicine

 


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