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Infectious Diseases (all articles)

RCT | Fecal microbiota transplantation better than standard of care for first or second Clostridioides difficile infection.

26 Sep, 2022 | 12:08h | UTC

Faecal microbiota transplantation for first or second Clostridioides difficile infection (EarlyFMT): a randomised, double-blind, placebo-controlled trial – The Lancet Gastroenterology & Hepatology (link to abstract – $ for full-text)

Commentary: New FMT Trial Halted Due to Effectiveness – HCP Live

 

Commentary from the author on Twitter (thread – click for more)

 


Diagnosis and management of Monkeypox: a review for the emergency clinician.

26 Sep, 2022 | 12:07h | UTC

Diagnosis and Management of Monkeypox: A Review for the Emergency Clinician – Annals of Emergency Medicine

Related:

Monkeypox: disease epidemiology, host immunity and clinical interventions.

Monkeypox: A clinical update for paediatricians – Journal of Pediatrics and Child Health

Cohort Study | Clinical presentation and virological assessment of confirmed human monkeypox virus cases in Spain.

CDC Report | Epidemiologic and clinical characteristics of Monkeypox cases in the US.

Update on the Monkeypox Outbreak – JAMA

Antivirals with Activity Against Monkeypox: A Clinically Oriented Review – Clinical Infectious Diseases

Clinical features and novel presentations of human monkeypox in a central London centre during the 2022 outbreak: descriptive case series – The BMJ

WHO Declares Global Public Health Emergency Over Monkeypox Virus Outbreak – Health Policy Watch

Monkeypox Virus Infection in Humans across 16 Countries — April–June 2022 – New England Journal of Medicine

Monkeypox: A Contemporary Review for Healthcare Professionals – Open Forum Infectious Diseases

 


M-A | Antibiotics vs. no treatment for asymptomatic bacteriuria in residents of aged care facilities.

26 Sep, 2022 | 12:06h | UTC

Antibiotics versus no treatment for asymptomatic bacteriuria in residents of aged care facilities: a systematic review and meta-analysis – British Journal of General Practice

Related:

USPSTF Recommendation Statement: Screening for Asymptomatic Bacteriuria in Adults

Most doctors still believe in prescribing unnecessary antibiotics to treat asymptomatic bacteriuria, study suggests.

Randomized trial: Antibiotics vs. no therapy in kidney transplant recipients with asymptomatic bacteriuria

 


Long covid—an update for primary care.

23 Sep, 2022 | 13:10h | UTC

Long covid—an update for primary care – The BMJ

 


RCT | Helmet noninvasive ventilation no better than usual respiratory support for acute hypoxemic respiratory failure due to COVID-19.

22 Sep, 2022 | 13:11h | UTC

Effect of Helmet Noninvasive Ventilation vs Usual Respiratory Support on Mortality Among Patients With Acute Hypoxemic Respiratory Failure Due to COVID-19: The HELMET-COVID Randomized Clinical Trial – JAMA

 

Commentary on Twitter

 


Understanding post-COVID-19 interstitial lung disease: a new fibroinflammatory disease entity.

22 Sep, 2022 | 13:09h | UTC

Understanding post-COVID-19 interstitial lung disease (ILD): a new fibroinflammatory disease entity – Intensive Care Medicine

 

Commentary on Twitter

 


Impact of routine childhood immunization in reducing vaccine-preventable diseases in the US.

21 Sep, 2022 | 13:11h | UTC

Impact of Routine Childhood Immunization in Reducing Vaccine-Preventable Diseases in the United States – Pediatrics

 


Brief Review | Source control in the management of sepsis and septic shock.

20 Sep, 2022 | 13:32h | UTC

Source control in the management of sepsis and septic shock – Intensive Care Medicine (if the link is paywalled, try this one)

 

Commentary on Twitter

 


RCT | Multiple doses of prophylactic intravenous antibiotics are no better than a single dose in implant-based breast reconstruction.

19 Sep, 2022 | 12:48h | UTC

Effectiveness of Single vs Multiple Doses of Prophylactic Intravenous Antibiotics in Implant-Based Breast Reconstruction: A Randomized Clinical Trial – JAMA Network Open

 

Commentary on Twitter

 


M-A | Safety of single-dose primaquine as a Plasmodium falciparum gametocytocide.

19 Sep, 2022 | 12:36h | UTC

Safety of single-dose primaquine as a Plasmodium falciparum gametocytocide: a systematic review and meta-analysis of individual patient data – BMC Medicine

 


The Lancet Commission on lessons for the future from the COVID-19 pandemic – “a massive global failure.”

16 Sep, 2022 | 13:03h | UTC

Homepage: The Lancet COVID-19 Commission

The Lancet Commission on lessons for the future from the COVID-19 pandemic

Editorial: COVID-19: the case for prosociality

News Release: New report details “massive global failures” of COVID-19 response, calls for improved multilateral cooperation to end pandemic and effectively manage future global health threats – The Lancet

Infographic: COVID-19 response: a massive global failure

Commentaries:

WHO responds to The Lancet COVID-19 Commission – World Health Organization

Covid-19: Commission describes “massive global failures” of pandemic response – The BMJ

Covid-19 death toll is a tragedy and ‘massive global failure at multiple levels,’ Lancet commission says – CNN

Lancet Commission on COVID-19 response: ‘Massive global failure’ – CIDRAP

 


RCT | Among neonates with probable bacterial infection, switching from intravenous to oral antibiotics (amoxicillin–clavulanic acid) was noninferior to a full course of intravenous antibiotics and resulted in shorter hospitalization (median duration of 3.4 vs. 6.8 days).

16 Sep, 2022 | 12:59h | UTC

Efficacy and safety of switching from intravenous to oral antibiotics (amoxicillin–clavulanic acid) versus a full course of intravenous antibiotics in neonates with probable bacterial infection (RAIN): a multicentre, randomised, open-label, non-inferiority trial – The Lancet Child & Adolescent Health (link to abstract – $ for full-text)

Commentary: Dutch team devise less painful ‘drip and drink’ antibiotics treatment for babies – Dutch News

 

Commentaries on Twitter

(Thread – click for more)

 


Global, regional, and national burdens of HIV and other sexually transmitted infections in adolescents and young adults aged 10–24 years from 1990 to 2019: a trend analysis based on the Global Burden of Disease Study 2019.

16 Sep, 2022 | 12:50h | UTC

Global, regional, and national burdens of HIV and other sexually transmitted infections in adolescents and young adults aged 10–24 years from 1990 to 2019: a trend analysis based on the Global Burden of Disease Study 2019 – The Lancet Child & Adolescent Health (link to abstract – $ for full-text)

 

Commentary on Twitter

 


RCT | Effect of different itraconazole dosing regimens on cure rates, treatment duration, safety, and relapse rates in adult patients with tinea corporis/cruris.

15 Sep, 2022 | 13:10h | UTC

Effect of Different Itraconazole Dosing Regimens on Cure Rates, Treatment Duration, Safety, and Relapse Rates in Adult Patients With Tinea Corporis/Cruris: A Randomized Clinical Trial – JAMA Dermatology (free for a limited period)

 

Commentary on Twitter

 


Study reveals the risk factors associated with infection following operative vaginal birth.

15 Sep, 2022 | 13:02h | UTC

Factors associated with infection following operative vaginal birth – a secondary analysis of the ANODE randomized controlled trial – American Journal of Obstetrics and Gynecology

 


Systematic Review | Association of HIV infection with cardiovascular pathology based on advanced cardiovascular imaging.

15 Sep, 2022 | 13:02h | UTC

Association of HIV Infection With Cardiovascular Pathology Based on Advanced Cardiovascular Imaging: A Systematic Review – JAMA (free for a limited period)

Editorial: HIV, Subclinical Cardiovascular Disease, and Clinical Progression: Insights From Immunologic Heterogeneity – JAMA (free for a limited period)

 


M-A of randomized trials | In patients hospitalized with community-acquired pneumonia, corticosteroids reduce the need for mechanical ventilation without significant effects on mortality, treatment failure, or adverse events.

14 Sep, 2022 | 13:16h | UTC

Effect of corticosteroids on mortality and clinical cure in community-acquired pneumonia: A systematic review, meta-analysis, and meta-regression of randomized control trials – CHEST Journal (link to abstract – $ for full-text)

Related: Corticosteroids for CAP, influenza and COVID-19: when, how and benefits or harm? – European Respiratory Review

 


Review | Multisystem inflammatory syndrome in children (MIS-C) and neonates (MIS-N) associated with COVID-19: optimizing definition and management.

14 Sep, 2022 | 13:15h | UTC

Multisystem inflammatory syndrome in children (MIS-C) and neonates (MIS-N) associated with COVID-19: optimizing definition and management – Pediatrics Research

 

Commentary on Twitter

Under a http://creativecommons.org/licenses/by/4.0/ License

 


M-A | Antibiotic use in ambulatory care for acutely ill children in high-income countries.

14 Sep, 2022 | 13:10h | UTC

Antibiotic use in ambulatory care for acutely ill children in high-income countries: a systematic review and meta-analysis – Archives of Disease in Childhood

 


RCT | A double-dose influenza vaccination during hospitalization for acute coronary syndrome did not improve outcomes compared to standard-dose outpatient vaccination.

13 Sep, 2022 | 13:19h | UTC

Influenza vaccination strategy in acute coronary syndromes: the VIP-ACS trial – European Heart Journal

 

Commentary on Twitter

 


RCT | Anti-C5a antibody (vilobelimab) therapy for critically ill, invasively mechanically ventilated patients with COVID-19.

13 Sep, 2022 | 13:16h | UTC

Anti-C5a antibody (vilobelimab) therapy for critically ill, invasively mechanically ventilated patients with COVID-19 (PANAMO): a multicentre, double-blind, randomised, placebo-controlled, phase 3 trial – The Lancet Respiratory Medicine

 

Commentaries on Twitter

 


RCT | Dipeptidyl peptidase-1 inhibition does not improve outcomes in patients hospitalized with COVID-19.

13 Sep, 2022 | 13:15h | UTC

Dipeptidyl peptidase-1 inhibition in patients hospitalised with COVID-19: a multicentre, double-blind, randomised, parallel-group, placebo-controlled trial – The Lancet Respiratory Medicine

 

Commentary on Twitter

 


Retrospective Cohort Study | Outcomes of partial oral antibiotic treatment for complicated S. aureus bacteremia in people who inject drugs.

13 Sep, 2022 | 13:09h | UTC

Outcomes of Partial Oral Antibiotic Treatment for Complicated S. aureus Bacteremia in People Who Inject Drugs – Clinical Infectious Diseases (free PDF for a limited period)

 

Commentaries on Twitter

 


Review | Acute pancreatitis: diagnosis and treatment.

13 Sep, 2022 | 13:04h | UTC

Acute Pancreatitis: Diagnosis and Treatment – Drugs

Commentaries:

Revised Clinical Practice Guidelines of the Korean Pancreatobiliary Association for Acute Pancreatitis – Gut and Liver

Guidelines for the management of patients with severe acute pancreatitis, 2021 – Anaesthesia Critical Care & Pain Medicine

Evidence-Based Disposition of Acute Pancreatitis – emDocs

2019 WSES guidelines for the management of severe acute pancreatitis – World Journal of Emergency Surgery

American Gastroenterological Association Institute Guideline on Initial Management of Acute Pancreatitis

Pancreatitis – National Institute for Health and Care Excellence

 


RCT | Sulopenem vs. Ciprofloxacin for the treatment of uncomplicated urinary tract infections in women.

13 Sep, 2022 | 13:00h | UTC

Sulopenem or Ciprofloxacin for the Treatment of Uncomplicated Urinary Tract Infections in Women: A Phase 3 Randomized Trial – Clinical Infectious Diseases

Related: Sulopenem For The Treatment of Complicated Urinary Tract Infection Including Pyelonephritis: A Phase 3 Randomized Trial – Clinical Infectious Diseases

 


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