Infectious Diseases
Randomized trial: No benefit from discontinuing ACE Inhibitors and ARBs in patients admitted with COVID-19
20 Jan, 2021 | 01:55h | UTCCommentary: Discontinuing vs. Continuing ACEIs, ARBs in Patients Admitted With COVID-19 – American College of Cardiology
Related study (study and commentary): Randomized trial: Renin–angiotensin system inhibitors can be safely continued in patients admitted to hospital with COVID-19
Study: Crowded ICUs linked to increased mortality from COVID-19
20 Jan, 2021 | 01:53h | UTCCommentaries: Intensive Care Unit Strain and Mortality Risk Among Critically Ill Patients With COVID-19—There Is No “Me” in COVID – JAMA Network Open AND Crowded ICUs tied to higher risk of COVID-19 death – CIDRAP
What we know about Covid-19 reinfection so far
20 Jan, 2021 | 01:52h | UTCWhat we know about covid-19 reinfection so far – The BMJ
Commentary on Twitter
With most coronaviruses, recovery confers a degree of immunity to reinfection. But a small number of patients have caught #COVID19 for a second time.
What do we know and how worried we should be?https://t.co/NOA0TWAS2g@stokel
— The BMJ (@bmj_latest) January 19, 2021
SARS-CoV-2 vaccines: Much accomplished, much to learn
20 Jan, 2021 | 01:51h | UTCSARS-CoV-2 Vaccines: Much Accomplished, Much to Learn – Annals of Internal Medicine
Commentary on Twitter
New, from Dr. Fauci & colleagues
SARS-CoV-2 Vaccines: Much Accomplished, Much to Learn https://t.co/yguZOquGJF pic.twitter.com/OIBouGS6dr
— Ilan Schwartz MD PhD (@GermHunterMD) January 18, 2021
Study: Household transmission of SARS-CoV-2 and risk factors for susceptibility and infectivity
20 Jan, 2021 | 01:49h | UTC
Commentary on Twitter
A new, very large #SARSCoV2 household transmission study (27K households, 30K cases, 58K contacts)https://t.co/a89uAw3Ohg
—age ≥ 60 and infants most likely to get infected
—<age 20 most likely to infect others (1.6X)@TheLancetInfDis pic.twitter.com/nM044rVEdo— Eric Topol (@EricTopol) January 18, 2021
Study: Immune system ‘remembers’ coronavirus for at least 6 months
20 Jan, 2021 | 01:44h | UTCImmune system ‘remembers’ coronavirus for at least 6 months: study – MedicalXpress
Original study: Evolution of antibody immunity to SARS-CoV-2 – Nature
Commentary on Twitter
Just published @nature: Memory B cells to #SARSCoV2 from 87 infectees persist >6 months, evolve, more potent than original antibodies, likely more resistant to "escape" spike mutations, antigen persistence in gut in 7/14 biopsied https://t.co/ImuoZdfzJO
@c_gaebler @NussenzweigL pic.twitter.com/P1wahDOuiI— Eric Topol (@EricTopol) January 18, 2021
How effective is a single vaccine dose against Covid-19?
20 Jan, 2021 | 01:42h | UTCHow effective is a single vaccine dose against Covid-19? – BBC
What we now know — and don’t know — about the coronavirus variants
20 Jan, 2021 | 01:41h | UTCWhat we now know — and don’t know — about the coronavirus variants – STAT
Related: Covid-19: What new variants are emerging and how are they being investigated? – The BMJ
Perspective: Covid-19 vaccine guidance for those who are lactating is based on faulty assumptions, experts say
20 Jan, 2021 | 01:40h | UTC
Systematic review on prophylaxis for COVID-19: Hydroxychloroquine does not work, little evidence regarding other drugs
20 Jan, 2021 | 01:38h | UTCProphylaxis for COVID-19: a systematic review – Clinical Microbiology and Infection
Meta-analysis: Comparison of the loop technique with incision and drainage for skin and soft tissue abscesses
20 Jan, 2021 | 01:22h | UTC
Commentary on Twitter
Loop drainage technique (LDT) vs conventional I&D (CID) for cutaneous abscess
8 studies (n=910)
CID failed in 69/487 pts (14%)
LDT failed in 35/423 pts (8%)
OR 2.02 (95% CI 1.29 to 3.18) https://t.co/JVRZWFfyUe@MGottliebMD @GillianMD1 @AcademicEmerMed @SAEMonline #AEM pic.twitter.com/HJfnou4NYc— Gary D Peksa 💊 (@garyDpeksa) October 15, 2020
WHO chief warns against ‘catastrophic moral failure’ in COVID-19 vaccine access
19 Jan, 2021 | 01:58h | UTCWHO chief warns against ‘catastrophic moral failure’ in COVID-19 vaccine access – United Nations
Commentaries: Vaccine nationalism puts world on brink of ‘catastrophic moral failure’: WHO chief – Reuters AND Covid vaccine: WHO warns of ‘catastrophic moral failure’ – BBC
Evidence summary and clinical decision algorithm to guide clinicians in the care of the hypoxemic, non-intubated patients with suspected Covid-19
19 Jan, 2021 | 01:57h | UTC
Meta-analysis: Corticosteroid use in COVID-19 patients
19 Jan, 2021 | 01:56h | UTCRelated meta-analysis: Corticosteroids for Patients With Coronavirus Disease 2019 (COVID-19) With Different Disease Severity: A Meta-Analysis of Randomized Clinical Trials – Journal of Cardiothoracic and Vascular Anesthesia
IDSA: COVID-19 Diagnostic Guidelines Updates
19 Jan, 2021 | 01:54h | UTCCOVID-19 Diagnostic Guidelines Updates (Jan. 16, 2021) – Infectious Diseases Society of America
New calculator identifies COVID-19 patients at highest risk of deterioration
19 Jan, 2021 | 01:52h | UTCCommentaries: Improving clinical management of COVID-19: the role of prediction models – The Lancet Respiratory Medicine
Tool identifies COVID-19 patients at highest risk of deterioration – UK Research and Innovation
See calculator: 4C Mortality & 4C Deterioration
Commentary on Twitter
This model helps predict clinical deterioration of hospitalized patients with #COVID19 using 11 commonly measured/identifiable variables at the time of hospital contact.
Validated on ~75000 patients from 260 hospitals in the UK.
Nice.
By @Rishi_K_Gupta: https://t.co/OX8vtLtcVY pic.twitter.com/FEs5gZ9M5U
— Isaac Bogoch (@BogochIsaac) January 13, 2021
Covid-19: What new variants are emerging and how are they being investigated?
19 Jan, 2021 | 01:51h | UTCCovid-19: What new variants are emerging and how are they being investigated? – The BMJ
Rapid increase in covid cases ‘not due to the variant’, WHO says
19 Jan, 2021 | 01:49h | UTCRapid Increase In COVID Cases ‘Not Due To The Variant’, WHO Says – Health Policy Watch
Can COVID-19 cause diabetes?
19 Jan, 2021 | 01:48h | UTCCan COVID-19 cause diabetes? – Nature Reviews Endocrinology
Commentary on Twitter
Can #COVID19 induce #diabetes?
We don't know if #SARSCoV2 can directly damage pancreatic β-islet cells.
"If covid-19 were in fact to cause permanent insulin-dependent diabetes, SARS-CoV-2 would be unique." https://t.co/EMjW7d4Azv @NatMetabolism @ColumbiaMed Domenico Accili pic.twitter.com/HpNe9IToGm— Eric Topol (@EricTopol) January 12, 2021
Meta-analysis: saliva and nasopharyngeal swab nucleic acid amplification have similar diagnostic accuracy for the detection of SARS-CoV-2
19 Jan, 2021 | 01:46h | UTC
Clinical characteristics and outcomes of hospitalized women giving birth with and without COVID-19
19 Jan, 2021 | 01:45h | UTC
Commentary on Twitter
The higher rates of preterm birth, preeclampsia, thrombotic events and death in women giving birth with #COVID19 highlight the need for strategies to minimize risk https://t.co/W8PtvAKkgt
— JAMA Internal Medicine (@JAMAInternalMed) January 15, 2021
RECOVERY trial: No Benefit from convalescent plasma in hospitalized patients with Covid-19
17 Jan, 2021 | 22:26h | UTCCommentary: Covid: ‘Convalescent plasma no benefit to hospital patients’ – BBC
WHO: Infection prevention and control guidance for long-term care facilities in the context of COVID-19 update
17 Jan, 2021 | 22:24h | UTC
Characterization of the first 250 000 hospital admissions for COVID-19 in Brazil: a retrospective analysis of nationwide data
17 Jan, 2021 | 22:23h | UTC
[In Portuguese] Commentary from the author on Twitter (thread – click for more)
Descrição dos primeiros 250 mil pacientes com COVID-19 hospitalizados no Brasil no @LancetRespirMed
➡️Idade média 60 anos, um terço <50 anos
➡️39% na UTI / 23% ventilação invasiva
➡️2 em cada 5 morreram. 3 em cada 5 se foi para UTI
⬆️Diferenças regionaishttps://t.co/YAv0nosEaC pic.twitter.com/qQvA7uWgC6— Otavio Ranzani (@otavio_ranzani) January 15, 2021
Johnson & Johnson publishes early data for its Covid-19 vaccine candidate
17 Jan, 2021 | 22:22h | UTCCommentaries: Johnson & Johnson Publishes Early Data For Its Covid-19 Vaccine Candidate. The Vaccine Is A Few Months Behind The MRNA Options But May Eventually Offer Advantage AND Data fuel debate over whether J&J’s one-dose Covid vaccine will measure up – STAT