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Transplantation – Hematopoietic

RCT | Cyclophosphamide-based regimen enhances GVHD-free survival after hematopoietic stem-cell transplantation

27 Jun, 2023 | 13:54h | UTC

Summary: The article details a phase 3 trial comparing the efficacy of two graft-versus-host disease (GVHD) prophylactic regimens in hematologic cancer patients undergoing allogeneic hematopoietic stem-cell transplantation (HSCT). The experimental group received cyclophosphamide–tacrolimus–mycophenolate mofetil, and the standard group received tacrolimus–methotrexate. The patients, a total of 431, underwent HSCT from an HLA-matched related donor or a matched or 7/8 mismatched unrelated donor.

The primary end point was GVHD-free, relapse-free survival at 1 year. Results indicated a significantly higher incidence of this outcome in the experimental group (hazard ratio, 0.64; 95% confidence interval [CI], 0.49 to 0.83; P=0.001). At 1 year, adjusted GVHD-free, relapse-free survival was 52.7% (95% CI, 45.8 to 59.2) in the experimental group, compared to 34.9% (95% CI, 28.6 to 41.3) in the standard group.

Notably, patients in the experimental-prophylaxis group appeared to have less severe acute or chronic GVHD and a higher incidence of immunosuppression-free survival at 1 year. Overall survival, disease-free survival, relapse, transplantation-related death, and engraftment did not show a substantial difference between the groups. These results suggest that cyclophosphamide–tacrolimus–mycophenolate mofetil may offer a more effective prophylaxis against GVHD in HSCT patients.

Article: Post-Transplantation Cyclophosphamide-Based Graft-versus-Host Disease Prophylaxis – New England Journal of Medicine (link to abstract – $ for full-text)

News Release: Study Sets New Standard for Graft-Versus-Host Disease Prevention After Stem Cell Transplant – Johns Hopkins Medicine


Commentary on Twitter


Consensus Paper | Primary prophylaxis of invasive fungal diseases in patients with hematological malignancies

23 Jun, 2023 | 13:23h | UTC

Primary prophylaxis of invasive fungal diseases in patients with haematological malignancies: 2022 update of the recommendations of the Infectious Diseases Working Party (AGIHO) of the German Society for Haematology and Medical Oncology (DGHO) – Journal of Antimicrobial Chemotherapy


Review | Acute graft-versus-host disease

14 Jun, 2023 | 14:20h | UTC

Acute graft-versus-host disease – Nature Reviews Disease Primers (if the link is paywalled, try this one)


Commentary on Twitter


DNA sequencing may identify an increased risk of relapse in adults with AML prior to hematopoietic cell transplantation

13 Mar, 2023 | 14:47h | UTC

DNA Sequencing to Detect Residual Disease in Adults With Acute Myeloid Leukemia Prior to Hematopoietic Cell Transplant – JAMA (free for a limited period)

News Release: Blood test identifies acute myeloid leukemia patients at greater risk for relapse after bone marrow transplant – National Institutes of Health

Commentary: Blood Test May Identify Patients With AML at Greater Risk of Relapse After Bone Marrow Transplant – The ASCO Post


Commentary on Twitter


Review | Management of adult patients with hematological malignancies in critical care

10 Feb, 2023 | 13:45h | UTC

Management of adult patients with haematological malignancies in critical care – Anaesthesia


Cohort Study | Risk of malignant neoplasms of the gastrointestinal tract after blood or marrow transplant

30 Jan, 2023 | 00:23h | UTC

Malignant Neoplasms of the Gastrointestinal Tract After Blood or Marrow Transplant – JAMA Oncology (link to abstract – $ for full-text)

Commentary: Risk of Subsequent Gastrointestinal Tract Malignancies After Blood or Marrow Transplantation – The ASCO Post


Commentary on Twitter


ASCO Guideline | Management of fever and neutropenia in pediatric patients with cancer and hematopoietic cell transplantation recipients

24 Jan, 2023 | 14:28h | UTC

Guideline for the Management of Fever and Neutropenia in Pediatric Patients With Cancer and Hematopoietic Cell Transplantation Recipients: 2023 Update – Journal of Clinical Oncology


An investigational T-cell therapy shows promise against six viral infections common after stem cell transplants

13 Jan, 2023 | 13:10h | UTC

News Release: An investigational T-cell therapy shows promise against six viral infections common after stem cell transplants – American Association for Cancer Research

Original Article: Posoleucel, an Allogeneic, Off-the-Shelf Multivirus-Specific T-Cell Therapy, for the Treatment of Refractory Viral Infections in the Post-HCT Setting – Clinical Cancer Research

Commentary: Study Finds Posoleucel Demonstrated Antiviral Efficacy and Safety Against Viral Infections Following Allogeneic Stem Cell Transplantation – The ASCO Post


Joint consensus statement on the vaccination of adult and pediatric hematopoietic stem cell transplant recipients.

30 Nov, 2022 | 13:39h | UTC

Joint consensus statement on the vaccination of adult and paediatric haematopoietic stem cell transplant recipients: Prepared on behalf of the British society of blood and marrow transplantation and cellular therapy (BSBMTCT), the Children’s cancer and Leukaemia Group (CCLG), and British Infection Association (BIA) – Journal of Infection


Consensus Paper | Hematopoietic cell transplantation in the management of myelodysplastic syndrome.

29 Nov, 2022 | 14:11h | UTC

Hematopoietic Cell Transplantation in the Management of Myelodysplastic Syndrome: An Evidence-Based Review from the ASTCT Committee on Practice Guidelines – Transplantation and Cellular Therapy


Systematic Review | Stem cell transplantation for systemic sclerosis.

1 Aug, 2022 | 12:10h | UTC

Stem cell transplantation for systemic sclerosis – Cochrane Library

Summary: Stem cell transplantation for the treatment of systemic sclerosis – Cochrane Library


Cohort Study | Treatment outcomes and roles of transplantation and maintenance rituximab in patients with previously untreated mantle cell lymphoma.

5 Jul, 2022 | 11:39h | UTC

Treatment Outcomes and Roles of Transplantation and Maintenance Rituximab in Patients With Previously Untreated Mantle Cell Lymphoma: Results From Large Real-World Cohorts – Journal of Clinical Oncology

News Release: Mantle cell lymphoma treatment varies according to setting – Weill Cornell Medicine

Cohort Study: Burden of long-term morbidity borne by survivors of acute myeloid leukemia treated with blood or marrow transplantation.

29 Jun, 2022 | 10:56h | UTC

Burden of Long-Term Morbidity Borne by Survivors of Acute Myeloid Leukemia Treated With Blood or Marrow Transplantation: The Results of the BMT Survivor Study – Journal of Clinical Oncology


Commentary on Twitter

Under a license


Bring it on: Top five antimicrobial stewardship challenges in transplant infectious diseases and practical strategies to address them.

29 Apr, 2022 | 10:51h | UTC

Bring it on: Top five antimicrobial stewardship challenges in transplant infectious diseases and practical strategies to address them – Antimicrobial Stewardship & Healthcare Epidemiology


Commentary on Twitter

Under a license


Pre-transplant EASIX (endothelial activation and stress index) may predict the hazard of sepsis after allogeneic stem cell transplantation.

19 Apr, 2022 | 02:04h | UTC

Pre-transplant EASIX and sepsis after allogeneic stem cell transplantation – Intensive Care Medicine


Commentary on Twitter


A single-arm study evaluated Naive T-Cell depleted peripheral blood stem-cell grafts for the prevention of chronic graft-versus-host disease.

19 Jan, 2022 | 08:22h | UTC

Naive T-Cell Depletion to Prevent Chronic Graft-Versus-Host Disease – Journal of Clinical Oncology

Commentary: New graft strategy may improve outcomes for blood stem cell recipients – University of Pittsburg


RCT: Maribavir for refractory Cytomegalovirus infections with or without resistance post-transplant.

7 Dec, 2021 | 08:37h | UTC

Maribavir for Refractory Cytomegalovirus Infections With or Without Resistance Post-Transplant: Results from a Phase 3 Randomized Clinical Trial – Clinical Infectious Diseases


ASH 2021 guidelines for stem cell transplantation in patients with sickle cell disease.

14 Oct, 2021 | 09:53h | UTC

American Society of Hematology 2021 guidelines for sickle cell disease: stem cell transplantation – Blood

News release: ASH Releases New Clinical Practice Guidelines on Stem Cell Transplantation in Sickle Cell Disease

Commentary: ASH Issues Guideline on the Use of HSCT for Sickle Cell Disease – HealthDay


FDA authorizes additional Covid-19 vaccine dose for certain immunocompromised individuals – Other fully vaccinated individuals do not need an additional vaccine dose right now.

16 Aug, 2021 | 01:22h | UTC

Coronavirus (COVID-19) Update: FDA Authorizes Additional Vaccine Dose for Certain Immunocompromised Individuals – U.S. Food & Drug Administration


Statement on FDA Authorization of Supplemental Vaccine Dose for Immunocompromised Patients – Infectious Diseases Society of America

CDC, FDA recommend COVID booster for immune-compromised – CIDRAP

FDA authorizes additional dose of Covid-19 vaccine for the immunocompromised – STAT

The fine print: Understanding the new policy authorizing extra Covid vaccine doses for the immunocompromised – STAT

Covid booster: US approves third jab for the immunocompromised – BBC

CDC Committee Approves Third Covid-19 Shot For Immunocompromised People—Here’s Who Should Get One – Forbes

CDC Panel Recommends 3rd Vaccine Dose For Immunocompromised People – NPR

6 Things To Know If You’re Immunocompromised And Considering A 3rd Shot – NPR

CDC recommends third Covid-19 vaccine dose for certain immunocompromised people – CNN


Commentary on Twitter


RCT: Ruxolitinib for glucocorticoid-refractory chronic graft-versus-host disease.

16 Jul, 2021 | 10:37h | UTC

Ruxolitinib for Glucocorticoid-Refractory Chronic Graft-versus-Host Disease – New England Journal of Medicine


Review: Care for the organ transplant recipient on the intensive care unit

8 Apr, 2021 | 08:36h | UTC

Care for the organ transplant recipient on the intensive care unit – Journal of Critical Care


Review: Post-Transplant Pregnancy and Contraception

23 Mar, 2021 | 02:10h | UTC

Post-Transplant Pregnancy and Contraception – Clinical Journal of the American Society of Nephrology


Short review: Acute CV complications of hematopoietic stem cell transplantation

18 Feb, 2021 | 02:40h | UTC

Acute CV Complications of Hematopoietic Stem Cell Transplantation – American College of Cardiology


Cohort study: Long-term clinical outcomes of hematopoietic stem cell transplantation in 210 patients with multiple sclerosis

25 Jan, 2021 | 01:15h | UTC

Long-Term Clinical Outcomes of Hematopoietic Stem Cell Transplantation in Multiple Sclerosis – Neurology (link to abstract – $ for full-text)


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