Pain Medicine | Links Medicus Content Curation & Alerts in Medicine

M-A: Benefits and harms of interventions with surgery compared to interventions without surgery for musculoskeletal conditions.

24 Jun, 2022 | 11:04h | UTC

Benefits and Harms of Interventions With Surgery Compared to Interventions Without Surgery for Musculoskeletal Conditions: A Systematic Review With Meta-analysis – Journal of Orthopaedic & Sports Physical Therapy

M-A: Effectiveness of pharmacological-based interventions, including education and prescribing strategies, to reduce subacute pain after total hip or knee arthroplasty.

23 Jun, 2022 | 10:04h | UTC

Effectiveness of Pharmacological-Based Interventions, Including Education and Prescribing Strategies, to Reduce Subacute Pain After Total Hip or Knee Arthroplasty: A Systematic Review of Randomized Controlled Trials – Pain Medicine

Commentary: Multimodal Analgesia and Education Reduces Postoperative Arthroplasty Pain, Opioid Consumption – Rheumatology Advisor

Commentary on Twitter

A systematic review of RCTs looking at effectiveness of pharmacological interventions to ⬇️ pain following total hip/knee arthroplasty. Interventions involving multimodal non-opioid analgesia & education show positive effects on ⬇️ pain intensity. https://t.co/t2majwzHPz pic.twitter.com/HoybWv2VFO

— Pain Medicine Journal (@PainMedJournal) March 31, 2022

RCT: Spinal anesthesia is associated with more pain and prescription analgesic use after hip surgery compared to general anesthesia.

22 Jun, 2022 | 12:11h | UTC

News Release: Spinal Anesthesia Associated with More Pain, Prescription Analgesic Use After Hip Surgery Compared with General Anesthesia – American College of Physicians

Study: Pain, Analgesic Use, and Patient Satisfaction With Spinal Versus General Anesthesia for Hip Fracture Surgery: A Randomized Clinical Trial – Annals of Internal Medicine (link to abstract – $ for full-text)

Original Publication: Spinal Anesthesia or General Anesthesia for Hip Surgery in Older Adults – New England Journal of Medicine

Commentary: Spinal Anesthesia Tied to More Severe Pain After Hip Fracture Surgery – HealthDay

Long-term Survival after Combined Epidural–General Anesthesia or General Anesthesia Alone: Follow-up of a Randomized Trial – Anesthesiology

Delirium in Older Patients after Combined Epidural–General Anesthesia or General Anesthesia for Major Surgery: A Randomized Trial – Anesthesiology

Effect of Regional vs General Anesthesia on Incidence of Postoperative Delirium in Older Patients Undergoing Hip Fracture Surgery: The RAGA Randomized Trial – JAMA

Cohort Study: Association between short-term, chronic localized and chronic widespread pain and risk for cardiovascular disease.

22 Jun, 2022 | 11:18h | UTC

The association between short-term, chronic localized and chronic widespread pain and risk for cardiovascular disease in the UK Biobank – European Journal of Preventive Cardiology

M-A: Opioid versus opioid-free analgesia after surgical discharge.

21 Jun, 2022 | 11:08h | UTC

Opioid versus opioid-free analgesia after surgical discharge: a systematic review and meta-analysis of randomised trials – The Lancet (link to abstract – $ for full-text)

News Release: Taking opioids at home after surgery: More harms than benefits – McGill University Health Center

Cohort Study: Long-term risk of overdose or mental health crisis after opioid dose tapering.

14 Jun, 2022 | 10:53h | UTC

Long-term Risk of Overdose or Mental Health Crisis After Opioid Dose Tapering – JAMA Network Open

Editorial: New Data on Opioid Dose Reduction—Implications for Patient Safety – JAMA Network Open

News Release: Increased overdose and mental health risks persist two years after opioid dose reduction – UC Davis Center for Healthcare Policy and Research

Opioid-sparing effect of cannabinoids for analgesia: an updated systematic review and meta-analysis of preclinical and clinical studies.

14 Jun, 2022 | 10:30h | UTC

Opioid-sparing effect of cannabinoids for analgesia: an updated systematic review and meta-analysis of preclinical and clinical studies – Neuropsychopharmacology

Commentary on Twitter

MA of RCTs: In patients with cancer pain no effect of cannabinoid administration on opioid dose was found (MD= −3.8 mg; −10.97 to 3.37) or % change in pain scores (MD=1.84; −2.05 to 5.72) https://t.co/tTckc0z8Oz pic.twitter.com/Gh7LvYRz0n

— PfOL (@psychopharmacol) May 20, 2022

Systematic Review: Oxycodone for cancer‐related pain.

13 Jun, 2022 | 07:37h | UTC

Oxycodone for cancer‐related pain – Cochrane Library

Summary: Oxycodone for cancer-related pain in adults – Cochrane Library

Systematic Review: Cannabis-based products for chronic pain.

7 Jun, 2022 | 11:47h | UTC

Cannabis-Based Products for Chronic Pain: A Systematic Review – Annals of Internal Medicine

Annals Video Summary: Cannabis-Based Products for Chronic Pain: A Systematic Review

Summary for Patients: Cannabis-Based Products for Chronic Pain

Podcast: #338 LIVE! Medical Cannabis: Is it still dope? – The Curbsiders

Medicinal Cannabis for Chronic Pain: The Bermuda Triangle of Low Quality Studies, Countless Meta-analyses and Conflicting Recommendations – European Journal of Pain

RCT: Effect of medical marijuana card ownership on pain, insomnia, and affective disorder symptoms in adults.

Cohort Study: Long-term cannabis use is associated with cognitive deficits and smaller hippocampal volume in midlife.

AHA Scientific Statement | How does cannabis use affect brain health? Caution advised, more research needed.

M-A: Birth outcomes of neonates exposed to marijuana in utero.

Review: Cannabis-based medicines and medical cannabis for chronic neuropathic pain.

Cannabinoid metabolites as inhibitors of major hepatic CYP450 enzymes, with implications for cannabis-drug interactions.

Living Systematic Review on Cannabis and Other Plant-Based Treatments for Chronic Pain.

The International Cannabis Toolkit (iCannToolkit): a multidisciplinary expert consensus on minimum standards for measuring cannabis use.

Cannabis products are being sold as sleep remedies – here’s the evidence about their effectiveness.

Guideline: Medical cannabis or cannabinoids for chronic pain.

Cannabis and Cannabinoid Analgesia position statement – “Due to the lack of high-quality clinical evidence, the IASP does not currently endorse general use of cannabis and cannabinoids for pain relief.”

NICE Guideline: Cannabis-Based Medicinal Products

Consensus recommendations for perioperative management of cannabis and cannabinoid-based medicine users

Living Systematic Review on Cannabis and Other Plant-Based Treatments for Chronic Pain – Agency for Healthcare Research and Quality

Short Review: Drug Interactions with Cannabinoids

Meta-Analysis: Cannabinoids Not Effective for Cancer-Related Pain

Review: Considerations for cannabinoids in perioperative care by anesthesiologists.

Review: Cannabis-based Medicines and the Perioperative Physician

Study: Cannabis Use Disorder May Increase the Risk of Cardiovascular Events in Major Elective Surgeries

Perspective: If You Smoke Pot, Your Anesthesiologist Needs To Know

Perioperative Care of Cannabis Users: A Comprehensive Review of Pharmacological and Anesthetic Considerations

Podcast: Medical cannabis pearls.

6 Jun, 2022 | 10:58h | UTC

#338 LIVE! Medical Cannabis: Is it still dope? – The Curbsiders

Special Series: Pain management in the ICU.

31 May, 2022 | 11:52h | UTC

Editorial: Acute Pain Management – ICU Management & Practice

Series:

Pain Assessment in Critical Illness

Sedation, Analgesia and Respiratory Drive in Mechanically Ventilated Adults

Pain Management Specificities in Critically Ill Patients With Obesity

Analgesia, Sedation and Neuromuscular Blockade in Critically Ill Patients

Pain Management in Paediatric Critical Care

Editorial: Chance encounters, overdiagnosis, and overtreatment in orthopedic surgery.

30 May, 2022 | 11:43h | UTC

Editorial: Chance Encounters, Overdiagnosis, and Overtreatment – Clinical Orthopaedics and Related Research

Commentary on Twitter

"Shoulder, back, and knee pain are part of life and part of aging; when they overlap with age-related MRI findings, which probably do not have anything to do with the presenting complaint, we get overdiagnosis."https://t.co/XLG5RQ7vfo

— Derek Griffin (@DerekGriffin86) May 27, 2022

Cohort Study: Maternal over-the-counter analgesics use during pregnancy and adverse perinatal outcomes.

27 May, 2022 | 12:22h | UTC

Maternal over-the-counter analgesics use during pregnancy and adverse perinatal outcomes: cohort study of 151 141 singleton pregnancies – BMJ Open

News Release: Painkiller advice for pregnant women should always be followed, as use is linked to newborn problems – University of Aberdeen

Paracetamol use during pregnancy — a call for precautionary action – Nature Reviews Endocrinology

Editorial: Caution needed: paracetamol use in pregnancy – Nature Reviews Endocrinology

Association of Cord Plasma Biomarkers of In Utero Acetaminophen Exposure With Risk of Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder in Childhood – JAMA Psychiatry

Associations between paracetamol (acetaminophen) intake between 18 and 32 weeks gestation and neurocognitive outcomes in the child: A longitudinal cohort study – Pediatric and Perinatal Epidemiology

Prenatal Exposure to Acetaminophen and Risk for Attention Deficit Hyperactivity Disorder and Autistic Spectrum Disorder: A Systematic Review, Meta-Analysis, and Meta-Regression Analysis of Cohort Studies – American Journal of Epidemiology

RCT: Effect of acupoint hot compress on postpartum urinary retention after vaginal delivery.

24 May, 2022 | 07:55h | UTC

Effect of Acupoint Hot Compress on Postpartum Urinary Retention After Vaginal Delivery: A Randomized Clinical Trial – JAMA Network Open

Commentary on Twitter

In this RCT, acupoint hot compress (abdominal, lumbosacral & plantar) in the early postpartum period improved urinary retention, uterine contraction pain, depressive symptoms, and breast milk volume; it could be considered as an adjunct for self-care needs https://t.co/eEqAND1biw

— JAMA Network Open (@JAMANetworkOpen) May 23, 2022

Systematic Review: Prophylactic antiemetics for adults receiving intravenous opioids in the acute care setting.

23 May, 2022 | 01:29h | UTC

Prophylactic antiemetics for adults receiving intravenous opioids in the acute care setting – Cochrane Library

Summary: Prophylactic antiemetics for adults receiving intravenous opioids in the acute care setting – Cochrane Library

M-A: Comparison of Amitriptyline with other FDA–approved treatments for fibromyalgia.

20 May, 2022 | 10:49h | UTC

Comparison of Amitriptyline and US Food and Drug Administration–Approved Treatments for Fibromyalgia: A Systematic Review and Network Meta-analysis – JAMA Network Open

Discovery reveals blocking inflammation may lead to chronic pain.

19 May, 2022 | 11:06h | UTC

News Release: Discovery reveals blocking inflammation may lead to chronic pain – McGill University

Original Study: Acute inflammatory response via neutrophil activation protects against the development of chronic pain – Science Translational Medicine

Commentary on Twitter

Challenging medical dogma:
A very important new report suggests that non-steroidal inflammatory medications for acute pain can lead to chronic painhttps://t.co/Z8yjFFBCkK @ScienceTM https://t.co/YGjkXbvNTa pic.twitter.com/f4xVezAhau

— Eric Topol (@EricTopol) May 18, 2022