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Pain Medicine

RCT: After third molar surgery, Ibuprofen doses above 400 mg did not significantly increase the analgesic effect, and Paracetamol 1000/codeine 60 mg was not more effective than ibuprofen 400 mg.

17 Oct, 2021 | 21:16h | UTC

Analgesic effect of oral ibuprofen 400, 600, and 800 mg; paracetamol 500 and 1000 mg; and paracetamol 1000 mg plus 60 mg codeine in acute postoperative pain: a single-dose, randomized, placebo-controlled, and double-blind study – European Journal of Clinical Pharmacology

 

M-A: Effectiveness and safety of non-steroidal anti-inflammatory drugs and opioid treatment for knee and hip osteoarthritis – although Etoricoxib 60 mg/day and diclofenac 150 mg/day seem to be most effective treatments, topical diclofenac 70-81 mg/day is safer and should be considered as first line treatment.

17 Oct, 2021 | 21:14h | UTC

Effectiveness and safety of non-steroidal anti-inflammatory drugs and opioid treatment for knee and hip osteoarthritis: network meta-analysis – The BMJ

News release: Topical pain-killers more effective, safer than opioids for knee osteoarthritis pain – St. Michael’s Hospital

Commentary: Network meta-analysis compares analgesic regimens for osteoarthritis – medwire News

 

Commentary on Twitter

 

Podcast: Acute Pain Management for the Hospitalist.

14 Oct, 2021 | 09:47h | UTC

#299 Acute Pain Management for the Hospitalist – The Curbsiders

 

M-A: New pharmacologic agents (Ditans and Gepants) are not as good as triptans for treating migraines.

13 Oct, 2021 | 01:17h | UTC

Comparison of New Pharmacologic Agents With Triptans for Treatment of Migraine: A Systematic Review and Meta-analysis – JAMA Network Open

Commentary: Migraine: Older Drugs May Be Best Bet for Lessening Pain – Physician’s Weekly

 

Commentary on Twitter

 

Systematic Review: Is exercise an effective therapy to treat long-lasting low back pain?

3 Oct, 2021 | 22:32h | UTC

Summary: Is exercise an effective therapy to treat long-lasting low back pain? – Cochrane Library

Original Study: Exercise therapy for chronic low back pain – Cochrane Library

 

Commentary on Twitter

 

Cannabis products are being sold as sleep remedies – here’s the evidence about their effectiveness.

1 Oct, 2021 | 10:07h | UTC

Cannabis products are being sold as sleep remedies – here’s the evidence about their effectiveness – The Conversation

Related studies:

Cannabinol and Sleep: Separating Fact from Fiction – Cannabis and Cannabinoid Research

Medical Cannabis and Cannabinoids for Impaired Sleep: A Systematic Review and Meta-Analysis of Randomized Clinical Trials – Sleep (link to abstract – $ for full-text)

 

Guideline Synopsis: The Non-Surgical Management of Hip and Knee Osteoarthritis.

1 Oct, 2021 | 10:00h | UTC

Synopsis of the 2020 US Department of Veterans Affairs/US Department of Defense Clinical Practice Guideline: The Non-Surgical Management of Hip and Knee Osteoarthritis – Mayo Clinic Proceedings

 

RCT: Neurolytic splanchnic nerve block and pain relief, survival, and quality of life in unresectable pancreatic cancer.

30 Sep, 2021 | 10:16h | UTC

Neurolytic Splanchnic Nerve Block and Pain Relief, Survival, and Quality of Life in Unresectable Pancreatic Cancer: A Randomized Controlled Trial – Anesthesiology

 

Commentary on Twitter

 

Consensus Statement: Paracetamol use during pregnancy — a call for precautionary action – “Pregnant women should minimize risk by using the lowest effective APAP dose for the shortest possible time”.

26 Sep, 2021 | 22:02h | UTC

Paracetamol use during pregnancy — a call for precautionary action – Nature Reviews Endocrinology

Editorial: Caution needed: paracetamol use in pregnancy – Nature Reviews Endocrinology

Commentaries:

New research cautions about possible risks of acetaminophen use during pregnancy – STAT

Expert reaction to statement on paracetamol use during pregnancy – Science Media Centre

A Common Pain Relief Med Used in Pregnancy Should Be Taken with Caution, Experts Warn – ScienceAlert

Scientists suggest pregnant women only take paracetamol/acetaminophen if medically necessary – MedicalXpress

 

Commentary on Twitter

 

AAOS Updates Clinical Practice Guideline for Osteoarthritis of the Knee.

21 Sep, 2021 | 09:03h | UTC

News release: AAOS Updates Clinical Practice Guideline for Osteoarthritis of the Knee – American Academy of Orthopaedic Surgeons

Guideline summary: Management of Osteoarthritis of the Knee (Non-Arthroplasty) (3rd Edition) – American Academy of Orthopaedic Surgeons

Full paper: Management of Osteoarthritis of the Knee (Non-Arthroplasty) Evidence-Based Clinical Practice Guideline

 

Systematic Review: Interventional treatments for acute and chronic pain.

17 Sep, 2021 | 10:01h | UTC

Interventional Treatments for Acute and Chronic Pain: Systematic Review – Agency for Healthcare Research and Quality

Full report

Evidence summary

 

Guideline: Medical cannabis or cannabinoids for chronic pain.

10 Sep, 2021 | 05:22h | UTC

Medical cannabis or cannabinoids for chronic pain: a clinical practice guideline – The BMJ

See also: Medical cannabis or cannabinoids for chronic non-cancer and cancer related pain: a systematic review and meta-analysis of randomised clinical trials – The BMJ

Editorial: Medical cannabis for chronic pain – The BMJ

Related: Cannabis and Cannabinoid Analgesia position statement – “Due to the lack of high-quality clinical evidence, the IASP does not currently endorse general use of cannabis and cannabinoids for pain relief.” (several resources on the subject)

 

Commentary on Twitter

 

RCT: Ketamine administration in patients with acute painful sickle cell crisis was effective for pain control and reduced the cumulative morphine dose in the emergency department.

2 Sep, 2021 | 08:11h | UTC

Ketamine Administration for Acute Painful Sickle Cell Crisis: A Randomized Controlled Trial – Academic Emergency Medicine (link to abstract – $ for full-text)

 

Review: The role of regional analgesia in personalized postoperative pain management.

26 Aug, 2021 | 08:24h | UTC

The role of regional analgesia in personalized postoperative pain management – Korean Journal of Anesthesiology

 

RCT: A single-session of pain management skills intervention was noninferior to 8 sessions of cognitive behavioral therapy in adults with chronic low back pain.

24 Aug, 2021 | 08:39h | UTC

Comparison of a Single-Session Pain Management Skills Intervention With a Single-Session Health Education Intervention and 8 Sessions of Cognitive Behavioral Therapy in Adults With Chronic Low Back Pain: A Randomized Clinical Trial – JAMA Network Open

Commentaries:

Single two-hour session of pain management skills could offer as much benefit as longer-course of CBT – News Medical

New approach effectively relieves chronic low back pain – Stanford Medicine

 

Commentary on Twitter

 

Systematic review: Kinesio taping provides little or no benefit for rotator cuff disease.

16 Aug, 2021 | 00:52h | UTC

Kinesio taping for rotator cuff disease – Cochrane Library

Summary: Kinesio taping for rotator cuff disease – Cochrane Library

 

Commentary on Twitter

 

Guideline: Non-surgical interventions for lumbar spinal stenosis leading to neurogenic claudication.

13 Aug, 2021 | 09:03h | UTC

Non-Surgical Interventions for Lumbar Spinal Stenosis Leading To Neurogenic Claudication: A Clinical Practice Guideline – Journal of Pain

 

RCT: Decompression alone is non-inferior to decompression with fusion in patients with degenerative lumbar spondylolisthesis.

6 Aug, 2021 | 09:54h | UTC

Decompression with or without Fusion in Degenerative Lumbar Spondylolisthesis – New England Journal of Medicine

Commentary: Decompression Noninferior for Degenerative Spondylolisthesis – HealthDay

 

M-A: Pharmacotherapy for the prevention of chronic pain after surgery in adults.

6 Aug, 2021 | 09:51h | UTC

Pharmacotherapy for the Prevention of Chronic Pain after Surgery in Adults: An Updated Systematic Review and Meta-analysis – Anesthesiology

 

Commentary on Twitter

 

AAOS Guideline: Pharmacologic, physical, and cognitive pain alleviation for musculoskeletal extremity/pelvis surgery.

5 Aug, 2021 | 08:49h | UTC

Pharmacologic, Physical, and Cognitive Pain Alleviation for Musculoskeletal Extremity/Pelvis Surgery – American Academy of Orthopaedic Surgeons

Evidence summary: Pharmacologic, Physical, and Cognitive Pain Alleviation for Musculoskeletal Extremity/Pelvis Surgery

News release: Clinical Practice Guideline and Appropriate Use Criteria for the Evaluation of Pharmacologic, Physical, and Cognitive Pain Alleviation for Musculoskeletal Extremity/Pelvis Surgery

 

Cannabis and Cannabinoid Analgesia position statement – “Due to the lack of high-quality clinical evidence, the IASP does not currently endorse general use of cannabis and cannabinoids for pain relief.”

4 Aug, 2021 | 09:07h | UTC

International Association for the Study of Pain Presidential Task Force on Cannabis and Cannabinoid Analgesia position statement – Pain

See also:

Cannabinoids, cannabis, and cannabis-based medicine for pain management: a systematic review of randomised controlled trials – Pain

General risks of harm with cannabinoids, cannabis, and cannabis-based medicine possibly relevant to patients receiving these for pain management: an overview of systematic reviews – Pain

Commentary:

More evidence needed to back cannabis as pain treatment, says review – Imperial College London

Medicinal cannabis to manage chronic pain? We don’t have evidence it works – The Conversation

Related:

NICE Guideline: Cannabis-Based Medicinal Products

Consensus recommendations for perioperative management of cannabis and cannabinoid-based medicine users

Living Systematic Review on Cannabis and Other Plant-Based Treatments for Chronic Pain – Agency for Healthcare Research and Quality

Short Review: Drug Interactions with Cannabinoids

Meta-Analysis: Cannabinoids Not Effective for Cancer-Related Pain

 

Cohort study: Evidence of a potentially inappropriate and harmful prescribing cascade of gabapentinoid followed by a diuretic among older adults with lower back pain.

29 Jul, 2021 | 11:02h | UTC

Evidence of a gabapentinoid and diuretic prescribing cascade among older adults with lower back pain – Journal of the American Geriatrics Society (link to abstract – $ for full-text)

Related:

Are you the victim of a prescribing cascade?

Study: Evaluation of a Common Prescribing Cascade of Calcium Channel Blockers and Diuretics in Older Adults with Hypertension

Prescribing Cascade in a Cardiology Practice

 

Review: The routes of administration for acute postoperative pain medication.

22 Jul, 2021 | 10:46h | UTC

The Routes of Administration for Acute Postoperative Pain Medication – Pain and Therapy

 

RCT: Progressive exercise compared with best practice advice, with or without corticosteroid injection, for the treatment of patients with rotator cuff disorders.

22 Jul, 2021 | 10:42h | UTC

Progressive exercise compared with best practice advice, with or without corticosteroid injection, for the treatment of patients with rotator cuff disorders (GRASP): a multicentre, pragmatic, 2 × 2 factorial, randomised controlled trial – The Lancet

Commentaries: Optimising treatment for patients with rotator cuff disorders – The Lancet (free registration required)

 

Commentary on Twitter (thread – click for more)

 

Tramadol: Where do we go from here? – “Tramadol’s unpredictability, unique potential harms, and lack of advantage over other opioids or NSAIDs are now well recognized”.

15 Jul, 2021 | 09:14h | UTC

[131] Tramadol: Where do we go from here? – Therapeutic Initiative

 

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