Open access
Open access
Powered by Google Translator Translator

Pain Medicine

Phase 2 Trials | Selective NaV1.8 inhibitor, VX-548, shows potential in acute postoperative pain management

7 Aug, 2023 | 14:51h | UTC

Selective Inhibition of NaV1.8 with VX-548 for Acute Pain – New England Journal of Medicine (link to abstract – $ for full-text)

Video Summary: Selective Inhibition of NaV1.8 for Acute Pain | NEJM

Commentaries:

High-Dose VX-548 Reduces Acute Pain Post-Surgery – HCP Live

High-Dose VX-548 Reduces Acute Pain Over 48 Hours – HealthDay

 

Commentary on Twitter

 

RCT | Atogepant outperforms placebo in reducing migraines over 12 weeks

2 Aug, 2023 | 13:56h | UTC

Atogepant for the preventive treatment of chronic migraine (PROGRESS): a randomised, double-blind, placebo-controlled, phase 3 trial – The Lancet (link to abstract – $ for full-text)

 

Review | Painful diabetic peripheral neuropathy

20 Jul, 2023 | 10:53h | UTC

Painful Diabetic Peripheral Neuropathy: Practical Guidance and Challenges for Clinical Management – Diabetes, Metabolic Syndrome and Obesity

 

Clinical practice guideline for deprescribing opioid analgesics

12 Jul, 2023 | 13:58h | UTC

Clinical practice guideline for deprescribing opioid analgesics: summary of recommendations – Medical Journal of Australia

Related:

RCT | Opioids not more effective than placebo for acute low back and neck pain

Deprescribing considerations for older people in general practice – Australian Journal of General Practice

Deprescribing Strategies for Opioids and Benzodiazepines with Emphasis on Concurrent Use: A Scoping Review – Journal of Clinical Medicine

An Overview of Systematic Reviews and Meta-Analyses on the Effect of Medication Interventions Targeting Polypharmacy for Frail Older Adults – Journal of Clinical Medicine

Physician-led medication reviews in polypharmacy patients treated with at least 12 medications in a type 2 diabetes outpatient clinic: a randomised trial – Diabetic Medicine

RCT | A deprescribing intervention reduced medication burden among older adults in post-acute care

Achieving sustainable healthcare through deprescribing of unnecessary medications: making sense of the evidence – Cochrane Library

Deprescribing medicines in older people living with multimorbidity and polypharmacy: the TAILOR evidence synthesis – Health Technology Assessment

Barriers and facilitators to deprescribing of cardiovascular medications: a systematic review – BMJ Open

A National Modified Delphi Consensus Process to Prioritize Experiences and Interventions for Antipsychotic Medication Deprescribing Among Adult Patients With Critical Illness – Critical Care Explorations

Deprescribing proton pump inhibitors – Australian Journal of General Practice

Medication reviews and deprescribing as a single intervention in falls prevention: a systematic review and meta-analysis – Age and Ageing

Optimizing Medication Use in Older Adults With Rheumatic Musculoskeletal Diseases: Deprescribing as an Approach When Less May Be More – ACP Open Rheumatology

Facing the challenge of polypharmacy when prescribing for older people with cardiovascular disease. A review by the European Society of Cardiology Working Group on Cardiovascular Pharmacotherapy – European Heart Journal – Cardiovascular Pharmacotherapy

Deprescribing in Older Adults with Cardiovascular Disease – Journal of the American College of Cardiology

Multimorbidity in Older Adults with Cardiovascular Disease – American College of Cardiology, Latest in Cardiology

Antihypertensive Deprescribing in Older Adults: a Practical Guide – Current Hypertension Reports

How-to guide for medication reviews in older adults with cancer: A Young International Society of Geriatric Oncology and Nursing & Allied Health Interest Group initiative – Journal of Geriatric Oncology

Deprescribing in Palliative Cancer Care – Life

Less is More: Deprescribing Medications in Older Adults with Kidney Disease: A Review – Kidney360

Process evaluation of implementation strategies to reduce potentially inappropriate medication prescribing in older population: A scoping review – Research in Social and Administrative Pharmacy

AGA Clinical Practice Update on De-Prescribing of Proton Pump Inhibitors: Expert Review – Gastroenterology

Development of a Metric to Detect and Decrease Low-Value Prescribing in Older Adults – JAMA Network Open

The MedSafer Study—Electronic Decision Support for Deprescribing in Hospitalized Older Adults: A Cluster Randomized Clinical Trial – JAMA Internal Medicine

Quantifying Anticholinergic Burden and Sedative Load in Older Adults with Polypharmacy: A Systematic Review of Risk Scales and Models – Drugs & Aging

Deprescribing in palliative patients with cancer: a concise review of tools and guidelines – Supportive Care in Cancer

Prescribing practices, patterns, and potential harms in patients receiving palliative care: A systematic scoping review – Exploratory Research in Clinical and Social Pharmacy

A narrative review of evidence to guide deprescribing among older adults – Journal of General and Family Medicine

Polypharmacy, inappropriate prescribing, and deprescribing in older people: through a sex and gender lens – The Lancet Health Longevity

Polypharmacy Management in Older Patients – Mayo Clinic Proceedings

Psychopharmacological Treatment in Older People: Avoiding Drug Interactions and Polypharmacy – Deutsches Ärzteblatt international

Eliminating Medication Overload: A National Action Plan – Lown Institute

International Group for Reducing Inappropriate Medication Use & Polypharmacy (IGRIMUP): Position Statement and 10 Recommendations for Action – Drugs & Aging

Common ED Medication Errors: Polypharmacy – emDocs

Current and future perspectives on the management of polypharmacy – BMC Family Practice

Routine deprescribing of chronic medications to combat polypharmacy – Therapeutic Advances in Drug Safety

Polypharmacy—an Upward Trend with Unpredictable Effects – Deutsches Ärzteblatt international

Clinical Consequences of Polypharmacy in Elderly – Expert Opinion on Drug Safety

 

M-A | The effect of blood pressure lowering medications on the prevention of episodic migraine

12 Jul, 2023 | 13:50h | UTC

The effect of blood pressure lowering medications on the prevention of episodic migraine: A systematic review and meta-analysis – Cephalalgia

News Release: New study shows common blood pressure meds underused for migraine – George Institute for Global Health

 

RCT | Opioids not more effective than placebo for acute low back and neck pain

5 Jul, 2023 | 01:15h | UTC

Opioid analgesia for acute low back pain and neck pain (the OPAL trial): a randomised placebo-controlled trial – The Lancet (link to abstract – $ for full-text)

News Releases:

Opioids no more effective than placebo for acute back and neck pain – University of Sidney

Opioid pain relievers do not reduce acute lower back and neck pain, study suggests – The Lancet

Commentary from the authors: Opioids don’t relieve acute low back or neck pain – and can result in worse pain, new study finds – The Conversation

 

M-A | Metoclopramide effective in acute migraine relief, comparable to most active drugs, superior to placebo

30 Jun, 2023 | 14:51h | UTC

The efficacy and safety of metoclopramide in relieving acute migraine attacks compared with other anti-migraine drugs: a systematic review and network meta-analysis of randomized controlled trials – BMC Neurology

 

RCT | Acupuncture, doxylamine–pyridoxine, and their combination in nausea treatment during pregnancy

29 Jun, 2023 | 13:56h | UTC

Acupuncture and Doxylamine–Pyridoxine for Nausea and Vomiting in Pregnancy: A Randomized, Controlled, 2 × 2 Factorial Trial – Annals of Internal Medicine (link to abstract – $ for full-text)

News Release: Acupuncture and doxylamine-pyridoxine beneficial for moderate to severe nausea and vomiting during pregnancy: Study – American College of Physicians

Commentary: Combo treatment eases nausea and vomiting of pregnancy – MDedge

 

Editorial | Who should judge treatment effects as unimportant?

22 Jun, 2023 | 15:05h | UTC

Who should judge treatment effects as unimportant? – Journal of Physiotherapy

 

Guidelines for the management of trigeminal neuralgia

20 Jun, 2023 | 12:43h | UTC

Guidelines for the management of trigeminal neuralgia – Cleveland Clinic Journal of Medicine

 

Practice advisory for preoperative and intraoperative pain management of thoracic surgical patients

19 Jun, 2023 | 14:05h | UTC

Part 1: Practice Advisory for Preoperative and Intraoperative Pain Management of Thoracic Surgical Patients – Anesthesia and Analgesia (free for a limited period)

Part 2: Practice Advisory for Preoperative and Intraoperative Pain Management of Cardiac Surgical Patients – Anesthesia and Analgesia (free for a limited period)

See also: Prevalence and Characteristics of Persistent Postoperative Pain After Thoracic Surgery: A Systematic Review and Meta-Analysis – Anesthesia and Analgesia (free for a limited period)

Infographic: Persistent Pain After Thoracic Surgery—What Works, What Doesn’t – Anesthesia and Analgesia (free for a limited period)

 

Evidence-based clinical practice guideline for deprescribing opioid analgesics

15 Jun, 2023 | 15:08h | UTC

Evidence-based clinical practice guideline for deprescribing opioid analgesics – University of Sidney

 

RCT | Cannabis-based medicines show no significant relief for moderate-to-severe cancer pain

15 Jun, 2023 | 15:10h | UTC

Cannabis‐based medicines and medical cannabis for adults with cancer pain – Cochrane Library

Summary: Cannabis-based medicines for cancer pain – Cochrane Library

 

Review | The cervical spine in tension type headache

13 Jun, 2023 | 13:58h | UTC

The cervical spine in tension type headache – Musculoskeletal Science and Practice

 

Commentary on Twitter

 

Systematic Review | Impact of physical therapies on pain, function, and life quality in myofascial pain syndrome

6 Jun, 2023 | 14:07h | UTC

The effect of therapeutic physical modalities on pain, function, and quality of life in patients with myofascial pain syndrome: a systematic review – BMC Musculoskeletal Disorders

 

M-A | Efficacy and safety of duloxetine in chronic musculoskeletal pain

5 Jun, 2023 | 13:09h | UTC

Efficacy and safety of duloxetine in chronic musculoskeletal pain: a systematic review and meta-analysis – BMC Musculoskeletal Disorders

 

ACR Guideline for exercise, rehabilitation, diet, and additional integrative interventions for rheumatoid arthritis

2 Jun, 2023 | 12:33h | UTC

2022 American College of Rheumatology Guideline for Exercise, Rehabilitation, Diet, and Additional Integrative Interventions for Rheumatoid Arthritis – Arthritis Care & Research

Editorial: Patient Perspectives on the 2022 American College of Rheumatology Guideline for Exercise, Rehabilitation, Diet, and Additional Integrative Interventions for Rheumatoid Arthritis – Arthritis Care & Research

News Release: New Guideline Introduces Recommendations for Integrative Approach to RA Treatment – American College of Rheumatology

 

Systematic review | Analgesic use in sports

2 Jun, 2023 | 12:17h | UTC

Analgesic Use in Sports: Results of a Systematic Literature Review – Deutsches Ärzteblatt International

 

Review | Medication-assisted recovery for opioid use disorder

2 Jun, 2023 | 12:03h | UTC

Medication-assisted recovery for opioid use disorder: A guide – Journal of Family Practice

 

Review | Deprescribing interventions for gabapentinoids in adults

1 Jun, 2023 | 12:05h | UTC

Deprescribing interventions for gabapentinoids in adults: a scoping review – British Journal of Clinical Pharmacology

 

Cohort Study | Prevalence and risk factors of significant persistent pain symptoms after critical care illness

31 May, 2023 | 14:00h | UTC

Prevalence and risk factors of significant persistent pain symptoms after critical care illness: a prospective multicentric study – Critical Care

 

RCT | Group support and skill-based learning reduce opioid use in chronic pain, but leads to no effect on pain perception

29 May, 2023 | 11:14h | UTC

Reducing Opioid Use for Chronic Pain With a Group-Based Intervention: A Randomized Clinical Trial – JAMA (free for a limited period)

See also: Visual Abstract

News Release: New treatment helps people stop addictive opioid painkillers used for chronic pain – University of Warwick

 

Advances and challenges in neuropathic pain: a narrative review and future directions

29 May, 2023 | 10:46h | UTC

Advances and challenges in neuropathic pain: a narrative review and future directions – British Journal of Anaesthesia

 

M-A | Limited evidence for safety and effectiveness of most antidepressants in chronic pain management

18 May, 2023 | 13:50h | UTC

Antidepressants for pain management in adults with chronic pain: a network meta‐analysis – Cochrane Library

News Release: Most antidepressants prescribed for chronic pain lack reliable evidence of efficacy or safety, scientists warn – Cochrane Library

Summary: How effective are antidepressants used to treat chronic pain and do they cause unwanted effects? – Cochrane Library

Commentary: Expert reaction to Cochrane review on antidepressants for pain management in adults with chronic pain – Science Media Centre

 

Towards precision pain medicine for pain after cancer: guidelines for pain phenotyping using nociplastic pain criteria

16 May, 2023 | 14:35h | UTC

Towards precision pain medicine for pain after cancer: the Cancer Pain Phenotyping Network multidisciplinary international guidelines for pain phenotyping using nociplastic pain criteria – British Journal of Anaesthesia

 

Commentary on Twitter

Article under a Creative Commons (CC BY-NC-ND 4.0) license

 

Stay Updated in Your Specialty

Telegram Channels
Free

WhatsApp alerts 10-day free trial

No spam, just news.