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Oncology

Meta-Analysis: Direct Oral Anticoagulants vs. Low‐molecular‐weight Heparin for the Treatment of Cancer‐associated Thrombosis

29 May, 2020 | 03:03h | UTC

Direct oral anticoagulants compared to low‐molecular‐weight heparin for the treatment of cancer‐associated thrombosis: Updated systematic review and meta‐analysis of randomized controlled trials – Research and Practice in Thrombosis and Haemostasis

“In patients with cancer‐associated VTE, DOACs are more effective in preventing recurrent VTE compared to LMWH. However, risk of bleeding is increased with DOACs, especially in patients with GI cancer.”

 


Meta-Analysis: Negative Predictive Value of MRI in the Detection of Clinically Significant Prostate Cancer

28 May, 2020 | 09:35h | UTC

Negative Predictive Value of Multiparametric Magnetic Resonance Imaging in the Detection of Clinically Significant Prostate Cancer in the Prostate Imaging Reporting and Data System Era: A Systematic Review and Meta-analysis – European Urology

 


Impact of COVID-19 on Oncology Clinical Trials

26 May, 2020 | 09:40h | UTC

Impact of COVID-19 on oncology clinical trials – Nature Reviews Drug Discovery

Commentary: More Than 200 International Cancer Trials Suspended Due to COVID-19 – Medscape (free registration required)

 


Summary of International Recommendations in 23 Languages for Patients with Cancer During the COVID-19 Pandemic

15 May, 2020 | 03:29h | UTC

Summary of international recommendations in 23 languages for patients with cancer during the COVID-19 pandemic – The Lancet Oncology

Related: ESMO Guidelines: Cancer Patient Management During the Covid-19 Pandemic (guidelines on the subject)

 


[Abstract Only] Randomized Trial: Improved Overall Survival with Atezolizumab plus Bevacizumab in Unresectable Hepatocellular Carcinoma

15 May, 2020 | 03:23h | UTC

Atezolizumab plus Bevacizumab in Unresectable Hepatocellular Carcinoma – New England Journal of Medicine

See also: Visual Abstract

 


[Abstract Only] Cost–benefit Analysis of Cancer Drugs in the USA and Europe

14 May, 2020 | 02:25h | UTC

Prices and clinical benefit of cancer drugs in the USA and Europe: a cost–benefit analysis – The Lancet Oncology (link to abstract – $ for full-text)

Commentaries: High cost of cancer drugs not always justified – University of Zurich AND High Cost of Cancer Drugs Does Not Reflect Clinical Benefit – Medscape

 


NCCN Guideline: Hematopoietic Cell Transplantation

10 May, 2020 | 23:53h | UTC

Hematopoietic Cell Transplantation, Version 2.2020, NCCN Clinical Practice Guidelines in Oncology – Journal of the National Comprehensive Cancer Network

 


ESMO Guidelines: Cancer Patient Management During the Covid-19 Pandemic

5 May, 2020 | 04:41h | UTC

Cancer Patient Management During the Covid-19 Pandemic – European Society of Medical Oncology

Related: NCCN Guidance: How to Keep our Oncology Patients and Healthcare Workers Safe AND ASCO Recommendations for the Oncology Community During the COVID19 Pandemic AND COVID-19 rapid guideline: delivery of systemic anticancer treatments – NICE AND COVID-19 rapid guideline: delivery of radiotherapy – NICE AND Caring for patients with cancer in the COVID-19 era – Nature Medicine

 


EULAR Recommendations: Diagnosis and Management of Rheumatic Adverse Events due to Cancer Immunotherapy

5 May, 2020 | 05:18h | UTC

EULAR points to consider for the diagnosis and management of rheumatic immune-related adverse events due to cancer immunotherapy with checkpoint inhibitors – Annals of Rheumatic Diseases

Related: Clinical characteristics of rheumatic syndromes associated with checkpoint inhibitors therapy – Rheumatology AND Musculoskeletal and Rheumatic Diseases Induced by Immune Checkpoint Inhibitors: A Review of the Literature – Current Drug Safety AND Immune-related Adverse Events Associated with Cancer Immunotherapy: A Review for the Practicing Rheumatologist – The Journal of Rheumatology AND NCCN Guidelines Insights: Management of Immunotherapy-Related Toxicities (guidelines and reviews on the subject)

 


Cohort Study: Five-year Outcomes of Magnetic Resonance Imaging–based Active Surveillance for Prostate Cancer

5 May, 2020 | 04:01h | UTC

Five-year Outcomes of Magnetic Resonance Imaging–based Active Surveillance for Prostate Cancer: A Large Cohort Study – European Urology

 


Randomized Trial: Hypofractionated Breast Radiotherapy for 1 Week Noninferior to 3 weeks

30 Apr, 2020 | 04:02h | UTC

Hypofractionated breast radiotherapy for 1 week versus 3 weeks (FAST-Forward): 5-year efficacy and late normal tissue effects results from a multicentre, non-inferiority, randomised, phase 3 trial – The Lancet

Commentaries: 1-week hypofractionated adjuvant whole-breast radiotherapy: towards a new standard? – The Lancet AND One-week course of radiotherapy could benefit women with early stage breast cancer, study finds – Institute of Cancer Research

 


[Abstract Only] Feasibility of Blood Testing Combined with PET-CT to Screen for Cancer and Guide Intervention

30 Apr, 2020 | 04:00h | UTC

Feasibility of blood testing combined with PET-CT to screen for cancer and guide intervention – Science (link to abstract – $ for full-text)

Commentaries: DNA blood test spots cancers in seemingly cancer-free women, but also produces false alarms – Science AND First study of multicancer blood test to screen for cancer guide intervention – Johns Hopkins Medicine

 


[Abstract Only] Randomized Trial: Olaparib for Metastatic Castration-Resistant Prostate Cancer

30 Apr, 2020 | 03:38h | UTC

Olaparib for Metastatic Castration-Resistant Prostate Cancer – New England Journal of Medicine

 


Patients with Cancer More Vulnerable to SARS-COV-2

29 Apr, 2020 | 05:00h | UTC

Patients with cancer appear more vulnerable to SARS-COV-2: a multi-center study during the COVID-19 outbreak – Cancer Discovery

Commentaries: COVID-19 Increases Overall Risk of Death, Complications in Patients With Cancer, Study Shows – AJMC AND Patients with blood and lung cancers are three times more at risk of dying of coronavirus than people with other tumors, study finds – Daily Mail AND Coronavirus: Cancer patients nearly three times more likely to die of Covid-19, study says – Independent

 


ASCO Guideline: Diagnosis and Management of Squamous Cell Carcinoma of Unknown Primary in the Head and Neck

29 Apr, 2020 | 04:43h | UTC

Diagnosis and Management of Squamous Cell Carcinoma of Unknown Primary in the Head and Neck: ASCO Guideline – Journal of Clinical Oncology

 


Study: Colorectal Cancer Incidence and Mortality After Removal of Adenomas During Screening Colonoscopies

24 Apr, 2020 | 03:24h | UTC

Colorectal Cancer Incidence and Mortality After Removal of Adenomas During Screening Colonoscopies – Gastroenterology

Related Study: Another Large Cohort Study Suggests Patients with Low-Risk Adenomas are Not At Increased Risk of Colorectal Cancer (studies on the subject)

 


Meta-Analysis: Interventions for the Management of Malignant Pleural Effusions

23 Apr, 2020 | 09:22h | UTC

Interventions for the management of malignant pleural effusions: a network meta‐analysis – Cochrane Library

 


[Abstract Only] Randomized Trial: Ruxolitinib for Glucocorticoid-Refractory Acute Graft-versus-Host Disease

23 Apr, 2020 | 09:14h | UTC

Ruxolitinib for Glucocorticoid-Refractory Acute Graft-versus-Host Disease – New England Journal of Medicine

 


Caring for Patients with Cancer in the COVID-19 Era

17 Apr, 2020 | 02:07h | UTC

Caring for patients with cancer in the COVID-19 era – Nature Medicine

Commentary: Caring for cancer patients in the COVID-19 era – Netherlands Cancer Institute

Related: NCCN Guidance: How to Keep our Oncology Patients and Healthcare Workers Safe AND ASCO Recommendations for the Oncology Community During the COVID19 Pandemic AND COVID-19 rapid guideline: delivery of systemic anticancer treatments – NICE AND COVID-19 rapid guideline: delivery of radiotherapy – NICE

 


Meta-Analysis: Aspirin and the Risk of Colorectal and Other Digestive Tract Cancers

17 Apr, 2020 | 01:54h | UTC

Aspirin and the risk of colorectal and other digestive tract cancers: an updated meta-analysis through 2019 – Annals of Oncology

News Release: Aspirin linked to reduction in risk of several cancers of the digestive tract – European Society of Medical Oncology

 


ASCO Recommendations for the Oncology Community During the COVID19 Pandemic

16 Apr, 2020 | 02:41h | UTC

Ethics and Resource Scarcity: ASCO Recommendations for the Oncology Community During the COVID19 Pandemic – American Society of Medical Oncology

Commentary: ASCO Releases New Guidance on Allocation of Limited Resources in the Oncology Community During COVID-19 Pandemic – The ASCO Post

 


NCCN Guideline: Breast Cancer

16 Apr, 2020 | 02:31h | UTC

Breast Cancer, Version 3.2020, NCCN Clinical Practice Guidelines in Oncology – Journal of the National Comprehensive Cancer Network

 


Guidelines for the Management of Hereditary Colorectal Cancer

16 Apr, 2020 | 02:28h | UTC

Guidelines for the management of hereditary colorectal cancer from the British Society of Gastroenterology (BSG)/Association of Coloproctology of Great Britain and Ireland (ACPGBI)/United Kingdom Cancer Genetics Group (UKCGG) – Gut

 


NCCN Guidance: How to Keep our Oncology Patients and Healthcare Workers Safe

10 Apr, 2020 | 03:17h | UTC

Safety at the Time of the COVID-19 Pandemic: How to Keep our Oncology Patients and Healthcare Workers Safe – Journal of the National Comprehensive Cancer Network

News Release: JNCCN: Improving COVID-19 safety for cancer patients and healthcare providers – National Comprehensive Cancer Network

 


ASCO Guideline: Management of Hereditary Breast Cancer

7 Apr, 2020 | 04:09h | UTC

Management of Hereditary Breast Cancer: American Society of Clinical Oncology, American Society for Radiation Oncology, and Society of Surgical Oncology Guideline – Journal of Clinical Oncology