Oncology (all articles) | Page 2 of 122 | Links Medicus Content Curation & Alerts in Medicine

European consensus-based interdisciplinary guideline for invasive cutaneous squamous cell carcinoma

1 Aug, 2023 | 14:24h | UTC

Part 1: Diagnostics and prevention – European Journal of Cancer

Part 2: Treatment – European Journal of Cancer

Nonrandomized Controlled Trial | Long-term survival of 80% in selected colorectal cancer patients post liver transplant

1 Aug, 2023 | 14:20h | UTC

Long-Term Survival, Prognostic Factors, and Selection of Patients With Colorectal Cancer for Liver Transplant: A Nonrandomized Controlled Trial – JAMA Surgery (link to abstract – $ for full-text)

Commentary on Twitter

Selected patients with liver-only CRLM and favorable pre-transplant prognostic scoring have long-term OS comparable to conventional indications for LT, providing a potential curative treatment option in patients otherwise offered only palliative treatments https://t.co/Xso5R7IDsX pic.twitter.com/uwEWijcrBp

— JAMA Surgery (@JAMASurgery) July 26, 2023

RCT | Niraparib after first-line platinum-based chemotherapy extends PFS vs. placebo in newly diagnosed advanced ovarian cancer

31 Jul, 2023 | 13:58h | UTC

Treatment With Niraparib Maintenance Therapy in Patients With Newly Diagnosed Advanced Ovarian Cancer: A Phase 3 Randomized Clinical Trial – JAMA Oncology

See also: Visual Abstract

Commentary: Niraparib Maintenance in Newly Diagnosed Advanced Ovarian Cancer – The ASCO Post

Review | The evolving landscape of salivary gland tumors

27 Jul, 2023 | 12:58h | UTC

The evolving landscape of salivary gland tumors – CA: A Cancer Journal for Clinicians

Perspective | Reconsidering the language of serious illness

26 Jul, 2023 | 13:29h | UTC

Reconsidering the Language of Serious Illness – JAMA (free for a limited period)

Commentary on Twitter

"When clinicians, from a position of authority, describe patients with respiratory failure as needing intubation, patients and families presume intubation is what should be done."

Reconsidering the Language of Serious Illness https://t.co/IXDtDDPYTw

— Shunichi Nakagawa (@snakagawa_md) July 24, 2023

RCT | Dysphagia-optimized intensity-modulated radiotherapy better preserves swallowing function in pharyngeal cancer patients

25 Jul, 2023 | 13:52h | UTC

Dysphagia-optimised intensity-modulated radiotherapy versus standard intensity-modulated radiotherapy in patients with head and neck cancer (DARS): a phase 3, multicentre, randomised, controlled trial – The Lancet Oncology

Commentaries:

Dysphagia-Optimized vs Standard IMRT in Newly Diagnosed Patients With Head and Neck Cancer – The ASCO Post

Radiation approach improves swallowing in head, neck cancer – MDedge

Commentary on Twitter

NOW OF: The (DARS) phase 3 RCT investigates if dysphagia-optimised intensity-modulated radiotherapy (IMRT) reduces radiation dose to the dysphagia and aspiration related structures and improves swallowing function compared with standard IMRT.#hncsm https://t.co/CzpxsNxx1N pic.twitter.com/xNgfm43tHE

— The Lancet Oncology (@TheLancetOncol) July 7, 2023

Phase 2 Trial | The addition of immunotherapy to stereotactic ablative radiotherapy may enhance EFS in early-stage NSCLC

25 Jul, 2023 | 13:36h | UTC

Stereotactic ablative radiotherapy with or without immunotherapy for early-stage or isolated lung parenchymal recurrent node-negative non-small-cell lung cancer: an open-label, randomised, phase 2 trial – The Lancet (link to abstract – $ for full-text)

Systematic Review | Post-mastectomy RT likely lowers recurrence and improves survival in early breast cancer with 1-3 positive nodes

25 Jul, 2023 | 13:34h | UTC

Post‐mastectomy radiotherapy for women with early breast cancer and one to three positive lymph nodes – Cochrane Library

Summary: Is X-ray treatment (radiotherapy) after removal of breast tissue (mastectomy) better than no X-ray treatment in women diagnosed with breast cancer that has spread to one to three armpit lymph nodes? – Cochrane Library

Review | Radiomics-based fertility-sparing treatment in endometrial carcinoma

24 Jul, 2023 | 13:00h | UTC

Radiomics-based fertility-sparing treatment in endometrial carcinoma: a review – Insights into Imaging

RCT | Combined pre-operative olanzapine regimen lowers postoperative nausea in high-risk cancer patients

24 Jul, 2023 | 12:49h | UTC

Olanzapine as an add-on, pre-operative anti-emetic drug for postoperative nausea or vomiting: a randomised controlled trial – Anaesthesia

Phase 2 Trial | Nivolumab shows promise as adjuvant therapy in completely resected Merkel cell carcinoma

20 Jul, 2023 | 11:02h | UTC

Adjuvant immunotherapy with nivolumab versus observation in completely resected Merkel cell carcinoma (ADMEC-O): disease-free survival results from a randomised, open-label, phase 2 trial – The Lancet (link to abstract – $ for full-text)

Commentary: Adjuvant Nivolumab vs Observation for Patients With Completely Resected Merkel Cell Carcinoma – The ASCO Post

Systematic Review | Platinum doublet therapy outperforms non-platinum for advanced NSCLC, performance status 2 patients

20 Jul, 2023 | 10:56h | UTC

Best first‐line therapy for people with advanced non‐small cell lung cancer, performance status 2 without a targetable mutation or with an unknown mutation status – Cochrane Library

Summary: Best therapy for people with advanced non-small cell lung cancer who have not been treated without a targetable mutation and moderately impaired performance status – Cochrane Library

ASCO Guideline | Practical assessment and management of vulnerabilities in older patients receiving systemic cancer therapy

19 Jul, 2023 | 14:31h | UTC

Practical Assessment and Management of Vulnerabilities in Older Patients Receiving Systemic Cancer Therapy: ASCO Guideline Update – Journal of Clinical Oncology

Systematic Review | An evidence-base for the implementation of hospital-based palliative care programs in routine cancer practice

19 Jul, 2023 | 14:23h | UTC

An evidence-base for the implementation of hospital-based palliative care programs in routine cancer practice: A systematic review – Palliative Medicine

IARC, WHO agency, identifies aspartame as potentially carcinogenic but probably safe within established acceptable daily intake

18 Jul, 2023 | 13:58h | UTC

News Release: Aspartame hazard and risk assessment results released – World Health Organization

Commentaries:

Expert reaction to IARC and JEFCA summary on aspartame – Science Media Centre

Does artificial sweetener aspartame really cause cancer? What the WHO listing means for your diet soft drink habit – The Conversation

Aspartame Hazard and Risk Assessment Results Released by IARC and JECFA – The ASCO Post

Single-arm study | Pembrolizumab plus Lenvatinib shows potential as first-line treatment for advanced non-clear-cell renal cell carcinoma

17 Jul, 2023 | 13:33h | UTC

Pembrolizumab plus lenvatinib as first-line therapy for advanced non-clear-cell renal cell carcinoma (KEYNOTE-B61): a single-arm, multicentre, phase 2 trial – The Lancet Oncology (link to abstract – $ for full-text)

TTMV-HPV DNA testing | Promising diagnostic and surveillance tool for HPV-linked oropharyngeal cancer

17 Jul, 2023 | 13:25h | UTC

Performance of Liquid Biopsy for Diagnosis and Surveillance of Human Papillomavirus–Associated Oropharyngeal Cancer – JAMA Otolaryngology–Head & Neck Surgery (free for a limited period)

Invited Commentary: Circulating Human Papillomavirus Tumor DNA—Ready for Prime Time? – – JAMA Otolaryngology–Head & Neck Surgery (free for a limited period)

Review | Guiding the use of invasive cardiac interventions in patients with advanced malignancies

17 Jul, 2023 | 13:23h | UTC

Invasive Cardiac Interventions in Patients With Active, Advanced Solid and Hematologic Malignancies: A Conceptual Framework: JACC: CardioOncology State-of-the-Art Review – JACC: CardioOncology

Consensus Paper | Ten recommendations for sarcoma surgery

14 Jul, 2023 | 12:49h | UTC

Ten recommendations for sarcoma surgery: consensus of the surgical societies based on the German S3 guideline “Adult Soft Tissue Sarcomas” – Langenbeck’s Archives of Surgery

RCT | Efficacy of different treatment regimens in unresectable colorectal cancer liver metastases

14 Jul, 2023 | 12:42h | UTC

First-line systemic treatment strategies in patients with initially unresectable colorectal cancer liver metastases (CAIRO5): an open-label, multicentre, randomised, controlled, phase 3 study from the Dutch Colorectal Cancer Group – The Lancet Oncology (link to abstract – $ for full-text)

Commentary on Twitter

ICYMI: The CAIRO5 open-label, multicentre, randomised, phase 3 trial of first-line systemic treatment strategies in patients with initially unresectable colorectal cancer liver metastases. #ccsm https://t.co/PiiwFcktLn pic.twitter.com/wlQbmuDLOW

— The Lancet Oncology (@TheLancetOncol) July 5, 2023

Cohort Study | Long-term cancer survivors face higher risk of noncancer death

14 Jul, 2023 | 12:38h | UTC

Relative Burden of Cancer and Noncancer Mortality Among Long-Term Survivors of Breast, Prostate, and Colorectal Cancer in the US – JAMA Network Open

Commentary on Twitter

Patients surviving ≥5 years from initial diagnosis of early breast, prostate, or colorectal cancer, the risk of dying from the cancer varied widely vs noncancer causes of death. Patients at low risk at diagnosis had a 3x higher risk of noncancer death. https://t.co/z2ffG9LqPv pic.twitter.com/HcqFkWAzZf

— JAMA Network Open (@JAMANetworkOpen) July 12, 2023

Phase 2 Study | BRAF-MEK inhibition in BRAF-mutated papillary craniopharyngiomas leads to tumor volume reduction

13 Jul, 2023 | 13:02h | UTC

BRAF–MEK Inhibition in Newly Diagnosed Papillary Craniopharyngiomas – New England Journal of Medicine (link to abstract – $ for full-text)

News Release: Rare Brain Tumor Responds to Targeted Tumor Treatment with ‘Unprecedented’ Success – Mass General Brigham

Commentary on Twitter

Genetic analysis has shown the presence of activating BRAF mutations in 94% of papillary craniopharyngiomas. A phase 2 study showed partial response or better in 15 of 16 previously untreated patients. Read the full study: https://t.co/UOjerJ17s3

— NEJM (@NEJM) July 12, 2023